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avrg: young vs old, Illumina Body Map 2 (GSE30611)

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Results for THRB

Z-value: 0.57

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Transcription factors associated with THRB

Gene Symbol Gene ID Gene Info
THRB
ENSG00000151090.20 THRB

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
THRBhg38_v1_chr3_-_24494740_24494758-0.655.7e-05Click!

Activity profile of THRB motif

Sorted Z-values of THRB motif

Network of associatons between targets according to the STRING database.

First level regulatory network of THRB

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr16_+_72054477 3.57 ENST00000355906.10
ENST00000570083.5
ENST00000228226.12
ENST00000398131.6
ENST00000569639.5
ENST00000564499.5
ENST00000357763.8
ENST00000613898.1
ENST00000562526.5
ENST00000565574.5
ENST00000568417.6
HP
haptoglobin
chr20_+_38805686 3.44 ENST00000299824.6
ENST00000373331.2
PPP1R16B
protein phosphatase 1 regulatory subunit 16B
chr16_+_72063226 3.38 ENST00000540303.7
ENST00000356967.6
ENST00000561690.1
HPR
haptoglobin-related protein
chr14_+_21712313 2.96 ENST00000390424.2
TRAV2
T cell receptor alpha variable 2
chr17_-_75844334 2.84 ENST00000592386.5
ENST00000412096.6
ENST00000586147.1
ENST00000207549.9
UNC13D
unc-13 homolog D
chr11_-_47378391 2.63 ENST00000227163.8
SPI1
Spi-1 proto-oncogene
chr11_-_47378479 2.52 ENST00000533968.1
SPI1
Spi-1 proto-oncogene
chr11_-_47378494 2.46 ENST00000533030.1
SPI1
Spi-1 proto-oncogene
chr11_-_47378527 2.42 ENST00000378538.8
SPI1
Spi-1 proto-oncogene
chr19_+_54573781 2.28 ENST00000391738.8
ENST00000251376.7
ENST00000391737.3
ENST00000629481.1
LILRA2
leukocyte immunoglobulin like receptor A2
chr14_-_106579223 2.19 ENST00000390626.2
IGHV5-51
immunoglobulin heavy variable 5-51
chr22_+_22369601 1.99 ENST00000390295.3
IGLV7-46
immunoglobulin lambda variable 7-46
chr17_-_75844533 1.95 ENST00000586108.1
UNC13D
unc-13 homolog D
chr8_-_130016414 1.60 ENST00000401979.6
ENST00000517654.5
ENST00000522361.1
ENST00000518167.5
CYRIB
CYFIP related Rac1 interactor B
chr7_-_38354517 1.59 ENST00000390345.2
TRGV4
T cell receptor gamma variable 4
chr22_+_22395005 1.51 ENST00000390298.2
IGLV7-43
immunoglobulin lambda variable 7-43
chr8_-_130016622 1.48 ENST00000518283.5
ENST00000519110.5
CYRIB
CYFIP related Rac1 interactor B
chr1_-_160647287 1.24 ENST00000235739.6
SLAMF1
signaling lymphocytic activation molecule family member 1
chr17_-_75843708 1.21 ENST00000590762.5
UNC13D
unc-13 homolog D
chr17_+_1742836 1.01 ENST00000324015.7
ENST00000450523.6
ENST00000453723.5
ENST00000453066.6
ENST00000382061.5
SERPINF2
serpin family F member 2
chr9_-_136373613 1.01 ENST00000641290.1
ENST00000371732.10
ENST00000371734.7
CARD9
caspase recruitment domain family member 9
chr10_+_58385395 0.81 ENST00000487519.6
ENST00000373895.7
TFAM
transcription factor A, mitochondrial
chr11_+_73787927 0.73 ENST00000537007.5
MRPL48
mitochondrial ribosomal protein L48
chr2_-_74465162 0.68 ENST00000649854.1
ENST00000650523.1
ENST00000649601.1
ENST00000448666.7
ENST00000409065.5
ENST00000414701.1
ENST00000452063.7
ENST00000649075.1
ENST00000648810.1
ENST00000462443.2
MOGS
mannosyl-oligosaccharide glucosidase
chr11_+_5596721 0.62 ENST00000354852.5
TRIM6-TRIM34
TRIM6-TRIM34 readthrough
chr17_+_7630094 0.60 ENST00000441599.6
ENST00000380450.9
ENST00000416273.7
ENST00000575903.5
ENST00000571153.5
ENST00000575618.5
ENST00000576152.1
ENST00000576830.5
SHBG
sex hormone binding globulin
chr8_+_28316979 0.55 ENST00000518479.5
PNOC
prepronociceptin
chr8_-_123025627 0.53 ENST00000519018.5
DERL1
derlin 1
chr1_-_207051202 0.51 ENST00000315927.9
YOD1
YOD1 deubiquitinase
chr21_-_36542600 0.49 ENST00000399136.5
CLDN14
claudin 14
chr11_+_73787853 0.41 ENST00000310614.12
ENST00000497094.6
ENST00000411840.6
ENST00000535277.5
ENST00000398483.7
ENST00000542303.5
MRPL48
mitochondrial ribosomal protein L48
chr15_-_100544341 0.40 ENST00000394113.5
CERS3
ceramide synthase 3
chr12_+_49346911 0.40 ENST00000395069.3
DNAJC22
DnaJ heat shock protein family (Hsp40) member C22
chr1_+_77532100 0.36 ENST00000478255.1
AK5
adenylate kinase 5
chr15_-_100544243 0.35 ENST00000538112.6
ENST00000559639.1
ENST00000558884.6
CERS3
ceramide synthase 3
chr11_-_18726187 0.34 ENST00000513874.6
IGSF22
immunoglobulin superfamily member 22
chr16_-_69334871 0.26 ENST00000562949.1
ENSG00000272617.3
novel protein, COG8-PDF readthrough
chr6_-_39322540 0.25 ENST00000425054.6
ENST00000373227.8
ENST00000373229.9
KCNK16
potassium two pore domain channel subfamily K member 16
chr12_+_49346885 0.24 ENST00000549441.7
DNAJC22
DnaJ heat shock protein family (Hsp40) member C22
chr15_-_100544677 0.23 ENST00000284382.8
CERS3
ceramide synthase 3
chr4_+_113292838 0.23 ENST00000672411.1
ENST00000673231.1
ANK2
ankyrin 2
chr2_-_9423340 0.21 ENST00000484735.5
ENST00000456913.6
ITGB1BP1
integrin subunit beta 1 binding protein 1
chrX_-_135868069 0.20 ENST00000604569.1
CT45A9
cancer/testis antigen family 45 member A9
chr20_+_408030 0.17 ENST00000640614.1
ENST00000475269.5
RBCK1
RANBP2-type and C3HC4-type zinc finger containing 1
chr8_-_99893135 0.17 ENST00000524245.5
COX6C
cytochrome c oxidase subunit 6C
chr1_-_154192058 0.17 ENST00000271850.11
ENST00000368530.7
ENST00000651641.1
TPM3
tropomyosin 3
chr10_+_60778490 0.11 ENST00000448257.6
ENST00000614696.4
CDK1
cyclin dependent kinase 1
chr7_+_103297425 0.09 ENST00000428154.5
ENST00000249269.9
PMPCB
peptidase, mitochondrial processing subunit beta
chr3_-_70312622 0.07 ENST00000567252.2
MDFIC2
MyoD family inhibitor domain containing 2
chrX_-_135833541 0.07 ENST00000620885.1
CT45A7
cancer/testis antigen family 45 member A7
chr5_-_157166262 0.05 ENST00000302938.4
FAM71B
family with sequence similarity 71 member B
chrX_-_135850791 0.05 ENST00000611438.1
CT45A8
cancer/testis antigen family 45 member A8
chr2_-_9423087 0.04 ENST00000467606.5
ENST00000494563.5
ENST00000460001.5
ITGB1BP1
integrin subunit beta 1 binding protein 1
chr11_-_56491370 0.03 ENST00000327216.5
OR5M8
olfactory receptor family 5 subfamily M member 8
chr20_+_408147 0.03 ENST00000441733.5
ENST00000353660.7
RBCK1
RANBP2-type and C3HC4-type zinc finger containing 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 6.0 GO:0002432 granuloma formation(GO:0002432)
1.4 10.0 GO:0044027 hypermethylation of CpG island(GO:0044027)
1.2 3.6 GO:2000296 negative regulation of hydrogen peroxide catabolic process(GO:2000296)
1.1 3.4 GO:1902309 negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.3 1.2 GO:0035744 T-helper 1 cell cytokine production(GO:0035744)
0.3 0.8 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.1 1.0 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.1 0.5 GO:1990168 protein K27-linked deubiquitination(GO:1990167) protein K33-linked deubiquitination(GO:1990168)
0.1 0.4 GO:0006173 dADP biosynthetic process(GO:0006173)
0.1 0.5 GO:0019060 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.1 1.0 GO:0032494 response to peptidoglycan(GO:0032494)
0.0 2.2 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 4.9 GO:0002377 immunoglobulin production(GO:0002377)
0.0 0.3 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.0 1.5 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 0.1 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.0 0.5 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.6 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.3 6.0 GO:0033093 Weibel-Palade body(GO:0033093)
0.2 3.4 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.1 0.5 GO:0036502 Derlin-1-VIMP complex(GO:0036502)
0.1 1.0 GO:0005577 fibrinogen complex(GO:0005577)
0.0 2.2 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 9.4 GO:0000790 nuclear chromatin(GO:0000790)
0.0 1.1 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.8 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.1 GO:0071797 LUBAC complex(GO:0071797)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 6.9 GO:0030492 hemoglobin binding(GO:0030492)
0.7 10.0 GO:0051525 NFAT protein binding(GO:0051525)
0.2 0.8 GO:0070363 mitochondrial light strand promoter sense binding(GO:0070363)
0.1 0.5 GO:1904455 ubiquitin-specific protease activity involved in negative regulation of ERAD pathway(GO:1904455)
0.1 0.5 GO:0001515 opioid peptide activity(GO:0001515)
0.1 0.6 GO:0005497 androgen binding(GO:0005497)
0.1 1.0 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.1 1.0 GO:0050700 CARD domain binding(GO:0050700)
0.0 9.2 GO:0003823 antigen binding(GO:0003823)
0.0 0.7 GO:0015926 glucosidase activity(GO:0015926)
0.0 6.0 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 3.1 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 0.5 GO:0042288 MHC class I protein binding(GO:0042288)
0.0 0.4 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 0.3 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 10.0 PID IL4 2PATHWAY IL4-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.0 1.0 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.0 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.2 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.5 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions