Project
avrg: young vs old, Illumina Body Map 2 (GSE30611)
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Results for TLX1_NFIC
Z-value: 0.47
Motif logo
Transcription factors associated with TLX1_NFIC
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
TLX1
|
ENSG00000107807.13 | TLX1 |
|
NFIC
|
ENSG00000141905.19 | NFIC |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFIC | hg38_v1_chr19_+_3314403_3314472 | 0.40 | 2.4e-02 | Click! |
| TLX1 | hg38_v1_chr10_+_101131284_101131321 | -0.27 | 1.4e-01 | Click! |
Activity profile of TLX1_NFIC motif
Sorted Z-values of TLX1_NFIC motif
Network of associatons between targets according to the STRING database.
First level regulatory network of TLX1_NFIC
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.9 | 15.4 | GO:1903609 | negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609) |
| 3.4 | 10.1 | GO:0043397 | corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397) |
| 3.3 | 9.8 | GO:1904204 | regulation of skeletal muscle hypertrophy(GO:1904204) |
| 2.9 | 14.6 | GO:0060611 | mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141) |
| 2.8 | 22.3 | GO:1902998 | regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 1.9 | 9.6 | GO:0060480 | lung goblet cell differentiation(GO:0060480) |
| 1.9 | 7.6 | GO:1903611 | regulation of calcium-dependent ATPase activity(GO:1903610) negative regulation of calcium-dependent ATPase activity(GO:1903611) regulation of dUTP diphosphatase activity(GO:1903627) positive regulation of dUTP diphosphatase activity(GO:1903629) negative regulation of aminoacyl-tRNA ligase activity(GO:1903631) regulation of leucine-tRNA ligase activity(GO:1903633) negative regulation of leucine-tRNA ligase activity(GO:1903634) |
| 1.8 | 9.0 | GO:0032765 | positive regulation of mast cell cytokine production(GO:0032765) |
| 1.5 | 5.9 | GO:1990637 | response to prolactin(GO:1990637) |
| 1.3 | 7.7 | GO:0035105 | sterol regulatory element binding protein import into nucleus(GO:0035105) |
| 1.1 | 3.3 | GO:0072209 | negative regulation of phosphatidylinositol biosynthetic process(GO:0010512) metanephric mesangial cell differentiation(GO:0072209) metanephric glomerular mesangial cell differentiation(GO:0072254) |
| 1.1 | 3.3 | GO:0061027 | umbilical cord morphogenesis(GO:0036304) umbilical cord development(GO:0061027) |
| 1.1 | 6.3 | GO:0072180 | mesonephric duct morphogenesis(GO:0072180) |
| 1.0 | 2.9 | GO:0070563 | negative regulation of vitamin D receptor signaling pathway(GO:0070563) |
| 1.0 | 2.9 | GO:0061537 | glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537) |
| 0.9 | 5.7 | GO:0098886 | modification of dendritic spine(GO:0098886) |
| 0.8 | 2.3 | GO:0098736 | regulation of cellular amine catabolic process(GO:0033241) negative regulation of cellular amine catabolic process(GO:0033242) negative regulation of the force of heart contraction(GO:0098736) regulation of arginine catabolic process(GO:1900081) negative regulation of arginine catabolic process(GO:1900082) regulation of citrulline biosynthetic process(GO:1903248) negative regulation of citrulline biosynthetic process(GO:1903249) negative regulation of cellular amino acid biosynthetic process(GO:2000283) |
| 0.7 | 23.7 | GO:0032060 | bleb assembly(GO:0032060) |
| 0.7 | 3.5 | GO:0038098 | sequestering of BMP from receptor via BMP binding(GO:0038098) |
| 0.7 | 0.7 | GO:0030240 | skeletal myofibril assembly(GO:0014866) skeletal muscle thin filament assembly(GO:0030240) |
| 0.7 | 2.0 | GO:0031104 | dendrite regeneration(GO:0031104) |
| 0.6 | 1.2 | GO:0060481 | lobar bronchus epithelium development(GO:0060481) |
| 0.6 | 1.2 | GO:0001300 | chronological cell aging(GO:0001300) |
| 0.6 | 1.9 | GO:0003099 | positive regulation of the force of heart contraction by chemical signal(GO:0003099) |
| 0.6 | 1.8 | GO:1902303 | regulation of heart rate by hormone(GO:0003064) negative regulation of potassium ion export(GO:1902303) |
| 0.6 | 2.3 | GO:0003095 | pressure natriuresis(GO:0003095) |
| 0.6 | 6.3 | GO:0051045 | negative regulation of membrane protein ectodomain proteolysis(GO:0051045) |
| 0.6 | 2.2 | GO:0033693 | neurofilament bundle assembly(GO:0033693) |
| 0.5 | 2.7 | GO:0044855 | plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906) |
| 0.5 | 16.1 | GO:0031639 | plasminogen activation(GO:0031639) |
| 0.5 | 2.4 | GO:1902460 | regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462) |
| 0.5 | 10.9 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.4 | 5.6 | GO:0051612 | negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.4 | 0.8 | GO:0042704 | uterine wall breakdown(GO:0042704) |
| 0.4 | 2.5 | GO:2000661 | positive regulation of interleukin-1-mediated signaling pathway(GO:2000661) |
| 0.4 | 4.6 | GO:0071073 | positive regulation of phospholipid biosynthetic process(GO:0071073) |
| 0.4 | 2.0 | GO:1902766 | skeletal muscle satellite cell migration(GO:1902766) |
| 0.4 | 2.8 | GO:2000860 | positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860) |
| 0.4 | 3.1 | GO:0021650 | vestibulocochlear nerve formation(GO:0021650) |
| 0.4 | 1.5 | GO:0034628 | nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process from aspartate(GO:0034628) |
| 0.4 | 5.3 | GO:2000427 | positive regulation of apoptotic cell clearance(GO:2000427) |
| 0.3 | 3.1 | GO:0048014 | Tie signaling pathway(GO:0048014) |
| 0.3 | 3.0 | GO:0061343 | cell adhesion involved in heart morphogenesis(GO:0061343) |
| 0.3 | 1.3 | GO:0021538 | epithalamus development(GO:0021538) habenula development(GO:0021986) |
| 0.3 | 5.7 | GO:0042940 | D-amino acid transport(GO:0042940) |
| 0.3 | 6.8 | GO:0001542 | ovulation from ovarian follicle(GO:0001542) |
| 0.3 | 0.9 | GO:1903697 | negative regulation of microvillus assembly(GO:1903697) |
| 0.3 | 6.5 | GO:0090026 | positive regulation of monocyte chemotaxis(GO:0090026) |
| 0.3 | 0.9 | GO:2000588 | positive regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000588) |
| 0.3 | 5.2 | GO:0032780 | negative regulation of ATPase activity(GO:0032780) |
| 0.3 | 3.5 | GO:2000645 | negative regulation of receptor catabolic process(GO:2000645) |
| 0.3 | 1.8 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 0.2 | 1.0 | GO:0060448 | neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007) dichotomous subdivision of terminal units involved in lung branching(GO:0060448) |
| 0.2 | 4.5 | GO:0071285 | cellular response to lithium ion(GO:0071285) |
| 0.2 | 1.3 | GO:0093001 | glycolysis from storage polysaccharide through glucose-1-phosphate(GO:0093001) |
| 0.2 | 2.3 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.2 | 8.2 | GO:0005980 | glycogen catabolic process(GO:0005980) |
| 0.2 | 1.2 | GO:0022614 | membrane to membrane docking(GO:0022614) |
| 0.2 | 1.2 | GO:0015862 | uridine transport(GO:0015862) |
| 0.2 | 4.1 | GO:0038007 | netrin-activated signaling pathway(GO:0038007) |
| 0.2 | 1.5 | GO:0051933 | amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935) |
| 0.2 | 2.9 | GO:0035826 | rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680) |
| 0.2 | 0.8 | GO:2000393 | negative regulation of lamellipodium morphogenesis(GO:2000393) |
| 0.2 | 4.1 | GO:1900119 | positive regulation of execution phase of apoptosis(GO:1900119) |
| 0.2 | 1.1 | GO:0099640 | axo-dendritic protein transport(GO:0099640) |
| 0.2 | 2.4 | GO:0016191 | synaptic vesicle uncoating(GO:0016191) |
| 0.2 | 3.4 | GO:0019371 | cyclooxygenase pathway(GO:0019371) |
| 0.2 | 2.9 | GO:1904706 | negative regulation of vascular smooth muscle cell proliferation(GO:1904706) |
| 0.1 | 3.7 | GO:0061162 | establishment of monopolar cell polarity(GO:0061162) |
| 0.1 | 3.5 | GO:0060907 | positive regulation of macrophage cytokine production(GO:0060907) |
| 0.1 | 4.3 | GO:0033622 | integrin activation(GO:0033622) |
| 0.1 | 2.1 | GO:0051451 | myoblast migration(GO:0051451) |
| 0.1 | 0.7 | GO:0015688 | iron chelate transport(GO:0015688) siderophore transport(GO:0015891) |
| 0.1 | 1.0 | GO:0003221 | right ventricular cardiac muscle tissue morphogenesis(GO:0003221) |
| 0.1 | 0.8 | GO:0090487 | toxin catabolic process(GO:0009407) secondary metabolite catabolic process(GO:0090487) |
| 0.1 | 1.0 | GO:0010499 | proteasomal ubiquitin-independent protein catabolic process(GO:0010499) |
| 0.1 | 0.7 | GO:0051758 | homologous chromosome movement towards spindle pole involved in homologous chromosome segregation(GO:0051758) |
| 0.1 | 4.6 | GO:0061436 | establishment of skin barrier(GO:0061436) |
| 0.1 | 1.6 | GO:0001886 | endothelial cell morphogenesis(GO:0001886) |
| 0.1 | 2.4 | GO:0061635 | regulation of protein complex stability(GO:0061635) |
| 0.1 | 5.9 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.1 | 0.5 | GO:0044376 | RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022) |
| 0.1 | 0.6 | GO:0035634 | response to stilbenoid(GO:0035634) |
| 0.1 | 3.7 | GO:0042744 | hydrogen peroxide catabolic process(GO:0042744) |
| 0.1 | 0.6 | GO:0060523 | prostate epithelial cord elongation(GO:0060523) |
| 0.1 | 1.8 | GO:0021869 | forebrain ventricular zone progenitor cell division(GO:0021869) |
| 0.1 | 0.7 | GO:0070966 | nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966) |
| 0.1 | 1.0 | GO:0018230 | peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231) |
| 0.1 | 0.7 | GO:0051012 | microtubule sliding(GO:0051012) |
| 0.1 | 2.4 | GO:2001256 | regulation of store-operated calcium entry(GO:2001256) |
| 0.1 | 0.3 | GO:0034970 | histone H3-R2 methylation(GO:0034970) |
| 0.1 | 1.2 | GO:0015705 | iodide transport(GO:0015705) |
| 0.1 | 1.9 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 0.1 | 2.2 | GO:0060044 | negative regulation of cardiac muscle cell proliferation(GO:0060044) |
| 0.1 | 0.5 | GO:1904428 | negative regulation of tubulin deacetylation(GO:1904428) |
| 0.1 | 0.3 | GO:0003365 | establishment of cell polarity involved in ameboidal cell migration(GO:0003365) |
| 0.1 | 1.6 | GO:1902902 | negative regulation of autophagosome assembly(GO:1902902) |
| 0.1 | 0.7 | GO:0006196 | AMP catabolic process(GO:0006196) adenosine biosynthetic process(GO:0046086) |
| 0.1 | 1.1 | GO:0042866 | pyruvate biosynthetic process(GO:0042866) |
| 0.1 | 1.2 | GO:0045329 | carnitine biosynthetic process(GO:0045329) |
| 0.1 | 0.4 | GO:0098957 | anterograde axonal transport of mitochondrion(GO:0098957) |
| 0.1 | 3.9 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.1 | 0.5 | GO:0019075 | virus maturation(GO:0019075) |
| 0.1 | 2.3 | GO:0016242 | negative regulation of macroautophagy(GO:0016242) |
| 0.1 | 1.1 | GO:0061002 | negative regulation of dendritic spine morphogenesis(GO:0061002) |
| 0.1 | 0.5 | GO:0061760 | antifungal humoral response(GO:0019732) antifungal innate immune response(GO:0061760) |
| 0.1 | 3.2 | GO:0010667 | negative regulation of cardiac muscle cell apoptotic process(GO:0010667) |
| 0.1 | 1.2 | GO:0031115 | negative regulation of microtubule polymerization(GO:0031115) |
| 0.1 | 0.7 | GO:0035166 | post-embryonic hemopoiesis(GO:0035166) |
| 0.1 | 0.5 | GO:2000619 | negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034) negative regulation of histone H4-K16 acetylation(GO:2000619) |
| 0.1 | 2.5 | GO:2001224 | positive regulation of neuron migration(GO:2001224) |
| 0.1 | 2.8 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.1 | 0.7 | GO:1904220 | regulation of serine C-palmitoyltransferase activity(GO:1904220) |
| 0.1 | 11.9 | GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625) |
| 0.1 | 2.3 | GO:0002230 | positive regulation of defense response to virus by host(GO:0002230) |
| 0.1 | 2.4 | GO:0038065 | collagen-activated signaling pathway(GO:0038065) |
| 0.1 | 0.4 | GO:1900106 | hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106) |
| 0.1 | 0.5 | GO:0070236 | negative regulation of activation-induced cell death of T cells(GO:0070236) |
| 0.1 | 0.2 | GO:0098974 | postsynaptic actin cytoskeleton organization(GO:0098974) |
| 0.1 | 1.3 | GO:1904714 | regulation of chaperone-mediated autophagy(GO:1904714) |
| 0.1 | 1.9 | GO:0060134 | prepulse inhibition(GO:0060134) |
| 0.1 | 0.9 | GO:0046415 | urate metabolic process(GO:0046415) |
| 0.1 | 0.2 | GO:0072137 | condensed mesenchymal cell proliferation(GO:0072137) |
| 0.1 | 1.6 | GO:0034063 | stress granule assembly(GO:0034063) |
| 0.1 | 3.2 | GO:0050819 | negative regulation of coagulation(GO:0050819) |
| 0.1 | 0.4 | GO:0032383 | regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383) |
| 0.1 | 0.3 | GO:0015015 | heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015) |
| 0.0 | 1.3 | GO:0033169 | histone H3-K9 demethylation(GO:0033169) |
| 0.0 | 0.9 | GO:2000465 | regulation of glycogen (starch) synthase activity(GO:2000465) |
| 0.0 | 0.7 | GO:0019532 | oxalate transport(GO:0019532) |
| 0.0 | 0.8 | GO:0097091 | synaptic vesicle clustering(GO:0097091) |
| 0.0 | 3.4 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 0.0 | 0.1 | GO:0043932 | ossification involved in bone remodeling(GO:0043932) |
| 0.0 | 3.0 | GO:0046710 | GDP metabolic process(GO:0046710) |
| 0.0 | 3.5 | GO:0007029 | endoplasmic reticulum organization(GO:0007029) |
| 0.0 | 0.8 | GO:0030208 | dermatan sulfate biosynthetic process(GO:0030208) |
| 0.0 | 2.0 | GO:0006783 | heme biosynthetic process(GO:0006783) |
| 0.0 | 2.5 | GO:1903861 | positive regulation of dendrite extension(GO:1903861) |
| 0.0 | 0.5 | GO:0043922 | negative regulation by host of viral transcription(GO:0043922) |
| 0.0 | 0.4 | GO:0098914 | membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914) |
| 0.0 | 0.1 | GO:0007228 | positive regulation of hh target transcription factor activity(GO:0007228) |
| 0.0 | 0.4 | GO:0030321 | transepithelial chloride transport(GO:0030321) |
| 0.0 | 5.5 | GO:0022617 | extracellular matrix disassembly(GO:0022617) |
| 0.0 | 0.5 | GO:0000244 | spliceosomal tri-snRNP complex assembly(GO:0000244) |
| 0.0 | 0.7 | GO:0097094 | craniofacial suture morphogenesis(GO:0097094) |
| 0.0 | 1.8 | GO:0035987 | endodermal cell differentiation(GO:0035987) |
| 0.0 | 0.4 | GO:0048539 | bone marrow development(GO:0048539) |
| 0.0 | 1.7 | GO:0045687 | positive regulation of glial cell differentiation(GO:0045687) |
| 0.0 | 1.2 | GO:0002089 | lens morphogenesis in camera-type eye(GO:0002089) |
| 0.0 | 0.8 | GO:0014912 | negative regulation of smooth muscle cell migration(GO:0014912) |
| 0.0 | 0.4 | GO:0006621 | protein retention in ER lumen(GO:0006621) |
| 0.0 | 1.6 | GO:0043030 | regulation of macrophage activation(GO:0043030) |
| 0.0 | 1.5 | GO:0019433 | triglyceride catabolic process(GO:0019433) |
| 0.0 | 3.8 | GO:1900034 | regulation of cellular response to heat(GO:1900034) |
| 0.0 | 4.1 | GO:0061418 | regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418) |
| 0.0 | 1.2 | GO:0006458 | 'de novo' protein folding(GO:0006458) |
| 0.0 | 1.0 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.0 | 0.6 | GO:0006692 | prostanoid metabolic process(GO:0006692) prostaglandin metabolic process(GO:0006693) |
| 0.0 | 0.4 | GO:2001016 | positive regulation of skeletal muscle cell differentiation(GO:2001016) |
| 0.0 | 0.4 | GO:0051967 | negative regulation of synaptic transmission, glutamatergic(GO:0051967) |
| 0.0 | 0.1 | GO:0006550 | isoleucine catabolic process(GO:0006550) acetyl-CoA catabolic process(GO:0046356) proximal convoluted tubule development(GO:0072019) metanephric proximal convoluted tubule development(GO:0072229) |
| 0.0 | 0.4 | GO:0007196 | adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196) |
| 0.0 | 4.0 | GO:0090090 | negative regulation of canonical Wnt signaling pathway(GO:0090090) |
| 0.0 | 1.1 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 0.0 | 5.6 | GO:0006986 | response to unfolded protein(GO:0006986) |
| 0.0 | 0.8 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
| 0.0 | 0.6 | GO:0036150 | phosphatidylserine acyl-chain remodeling(GO:0036150) |
| 0.0 | 0.7 | GO:0031954 | positive regulation of protein autophosphorylation(GO:0031954) |
| 0.0 | 0.1 | GO:0097475 | motor neuron migration(GO:0097475) |
| 0.0 | 0.1 | GO:0090037 | positive regulation of protein kinase C signaling(GO:0090037) |
| 0.0 | 0.2 | GO:0042268 | regulation of cytolysis(GO:0042268) |
| 0.0 | 1.0 | GO:0050435 | beta-amyloid metabolic process(GO:0050435) |
| 0.0 | 2.0 | GO:0006968 | cellular defense response(GO:0006968) |
| 0.0 | 0.3 | GO:0045955 | negative regulation of calcium ion-dependent exocytosis(GO:0045955) |
| 0.0 | 0.6 | GO:0070207 | protein homotrimerization(GO:0070207) |
| 0.0 | 0.5 | GO:0035855 | megakaryocyte development(GO:0035855) |
| 0.0 | 0.4 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
| 0.0 | 0.2 | GO:0048569 | post-embryonic organ development(GO:0048569) |
| 0.0 | 0.5 | GO:0035728 | response to hepatocyte growth factor(GO:0035728) |
| 0.0 | 1.2 | GO:0048747 | muscle fiber development(GO:0048747) |
| 0.0 | 0.4 | GO:0045292 | mRNA cis splicing, via spliceosome(GO:0045292) |
| 0.0 | 0.2 | GO:0072189 | ureter development(GO:0072189) |
| 0.0 | 2.9 | GO:0043542 | endothelial cell migration(GO:0043542) |
| 0.0 | 0.1 | GO:0070995 | NADPH oxidation(GO:0070995) |
| 0.0 | 1.6 | GO:0030449 | regulation of complement activation(GO:0030449) |
| 0.0 | 1.4 | GO:0043647 | inositol phosphate metabolic process(GO:0043647) |
| 0.0 | 0.6 | GO:0042462 | eye photoreceptor cell development(GO:0042462) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 5.7 | GO:0097444 | spine apparatus(GO:0097444) |
| 1.8 | 14.6 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 1.4 | 24.5 | GO:0097418 | neurofibrillary tangle(GO:0097418) |
| 0.9 | 3.7 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.9 | 12.5 | GO:0036454 | insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) |
| 0.8 | 0.8 | GO:0034665 | integrin alpha1-beta1 complex(GO:0034665) |
| 0.8 | 15.4 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
| 0.7 | 7.7 | GO:0005638 | lamin filament(GO:0005638) |
| 0.6 | 10.9 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.6 | 2.5 | GO:0070701 | mucus layer(GO:0070701) |
| 0.5 | 2.4 | GO:0034681 | integrin alpha11-beta1 complex(GO:0034681) |
| 0.4 | 1.2 | GO:0072563 | endothelial microparticle(GO:0072563) |
| 0.4 | 1.2 | GO:0071065 | alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065) |
| 0.4 | 1.8 | GO:1902937 | inward rectifier potassium channel complex(GO:1902937) |
| 0.3 | 1.0 | GO:0070931 | Golgi-associated vesicle lumen(GO:0070931) |
| 0.3 | 1.0 | GO:0060187 | cell pole(GO:0060187) |
| 0.3 | 1.1 | GO:1902912 | pyruvate kinase complex(GO:1902912) |
| 0.3 | 2.8 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.3 | 4.3 | GO:0005593 | FACIT collagen trimer(GO:0005593) |
| 0.3 | 3.4 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.2 | 3.5 | GO:0000137 | Golgi cis cisterna(GO:0000137) |
| 0.2 | 1.3 | GO:0005945 | 6-phosphofructokinase complex(GO:0005945) |
| 0.2 | 4.0 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.2 | 2.9 | GO:0097487 | multivesicular body, internal vesicle(GO:0097487) |
| 0.2 | 2.7 | GO:0030478 | actin cap(GO:0030478) |
| 0.2 | 2.4 | GO:0030314 | junctional membrane complex(GO:0030314) |
| 0.1 | 0.7 | GO:0042643 | actomyosin, actin portion(GO:0042643) |
| 0.1 | 0.4 | GO:0036117 | hyaluranon cable(GO:0036117) |
| 0.1 | 5.4 | GO:0043218 | compact myelin(GO:0043218) |
| 0.1 | 4.6 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.1 | 5.7 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.1 | 0.5 | GO:0034274 | Atg12-Atg5-Atg16 complex(GO:0034274) |
| 0.1 | 1.7 | GO:0002178 | palmitoyltransferase complex(GO:0002178) |
| 0.1 | 3.7 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.1 | 1.8 | GO:0042589 | zymogen granule membrane(GO:0042589) |
| 0.1 | 4.5 | GO:0008305 | integrin complex(GO:0008305) |
| 0.1 | 1.6 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.1 | 0.5 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 0.1 | 2.3 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.1 | 14.2 | GO:0005604 | basement membrane(GO:0005604) |
| 0.1 | 4.6 | GO:0030673 | axolemma(GO:0030673) |
| 0.1 | 6.5 | GO:0015030 | Cajal body(GO:0015030) |
| 0.1 | 1.2 | GO:0005832 | chaperonin-containing T-complex(GO:0005832) |
| 0.1 | 40.3 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.1 | 4.5 | GO:0032420 | stereocilium(GO:0032420) |
| 0.0 | 2.8 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 2.3 | GO:0097228 | sperm principal piece(GO:0097228) |
| 0.0 | 0.4 | GO:1990578 | perinuclear endoplasmic reticulum membrane(GO:1990578) |
| 0.0 | 1.4 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.0 | 0.6 | GO:0097550 | transcriptional preinitiation complex(GO:0097550) |
| 0.0 | 2.0 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.0 | 5.3 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 2.5 | GO:0043034 | costamere(GO:0043034) |
| 0.0 | 1.8 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
| 0.0 | 9.8 | GO:0043197 | dendritic spine(GO:0043197) |
| 0.0 | 5.1 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 1.4 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 4.1 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.0 | 0.9 | GO:0030122 | AP-2 adaptor complex(GO:0030122) |
| 0.0 | 0.5 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.0 | 0.5 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.0 | 3.5 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.0 | 1.2 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.0 | 2.3 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.0 | 2.1 | GO:0045334 | clathrin-coated endocytic vesicle(GO:0045334) |
| 0.0 | 0.4 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
| 0.0 | 0.7 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
| 0.0 | 0.6 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.0 | 5.6 | GO:0060076 | excitatory synapse(GO:0060076) |
| 0.0 | 4.1 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.0 | 1.3 | GO:0005901 | caveola(GO:0005901) |
| 0.0 | 2.9 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 5.0 | GO:0098793 | presynapse(GO:0098793) |
| 0.0 | 6.3 | GO:0045202 | synapse(GO:0045202) |
| 0.0 | 9.0 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 0.7 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
| 0.0 | 2.1 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 11.2 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.0 | 9.1 | GO:0009986 | cell surface(GO:0009986) |
| 0.0 | 0.2 | GO:0097433 | dense body(GO:0097433) |
| 0.0 | 1.5 | GO:1904813 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.0 | 0.4 | GO:0005771 | multivesicular body(GO:0005771) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.1 | 16.4 | GO:0005163 | nerve growth factor receptor binding(GO:0005163) |
| 3.9 | 15.4 | GO:0070320 | inward rectifier potassium channel inhibitor activity(GO:0070320) |
| 2.1 | 6.3 | GO:0060422 | peptidyl-dipeptidase inhibitor activity(GO:0060422) |
| 1.9 | 7.6 | GO:0004341 | gluconolactonase activity(GO:0004341) |
| 1.8 | 14.6 | GO:0005157 | macrophage colony-stimulating factor receptor binding(GO:0005157) |
| 1.6 | 8.2 | GO:0008466 | glycogenin glucosyltransferase activity(GO:0008466) |
| 1.0 | 2.9 | GO:0005055 | laminin receptor activity(GO:0005055) |
| 0.9 | 12.5 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 0.8 | 3.3 | GO:0035939 | microsatellite binding(GO:0035939) |
| 0.8 | 2.3 | GO:0036487 | nitric-oxide synthase inhibitor activity(GO:0036487) |
| 0.7 | 2.9 | GO:0015375 | glycine:sodium symporter activity(GO:0015375) |
| 0.6 | 21.6 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.6 | 1.8 | GO:0035375 | zymogen binding(GO:0035375) |
| 0.5 | 1.5 | GO:0033878 | hormone-sensitive lipase activity(GO:0033878) |
| 0.5 | 2.9 | GO:0018685 | alkane 1-monooxygenase activity(GO:0018685) |
| 0.4 | 13.9 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.4 | 1.5 | GO:0000309 | nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) |
| 0.4 | 3.4 | GO:0030345 | extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345) |
| 0.4 | 3.3 | GO:0098639 | collagen binding involved in cell-matrix adhesion(GO:0098639) |
| 0.4 | 1.8 | GO:0004667 | prostaglandin-D synthase activity(GO:0004667) |
| 0.4 | 2.5 | GO:0004909 | interleukin-1, Type I, activating receptor activity(GO:0004909) |
| 0.4 | 4.9 | GO:0036122 | BMP binding(GO:0036122) |
| 0.4 | 2.5 | GO:0004035 | alkaline phosphatase activity(GO:0004035) |
| 0.3 | 1.0 | GO:0043849 | Ras palmitoyltransferase activity(GO:0043849) |
| 0.3 | 3.0 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.3 | 1.6 | GO:0050220 | prostaglandin-E synthase activity(GO:0050220) |
| 0.3 | 0.9 | GO:2001069 | glycogen binding(GO:2001069) |
| 0.3 | 1.9 | GO:0031708 | endothelin B receptor binding(GO:0031708) |
| 0.3 | 4.6 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.3 | 10.4 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.3 | 1.2 | GO:0008336 | gamma-butyrobetaine dioxygenase activity(GO:0008336) |
| 0.3 | 1.1 | GO:0008426 | protein kinase C inhibitor activity(GO:0008426) |
| 0.2 | 6.3 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.2 | 1.0 | GO:0008798 | beta-aspartyl-peptidase activity(GO:0008798) |
| 0.2 | 3.3 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 0.2 | 7.8 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.2 | 5.4 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
| 0.2 | 1.2 | GO:0050436 | microfibril binding(GO:0050436) |
| 0.2 | 6.5 | GO:0031005 | filamin binding(GO:0031005) |
| 0.2 | 10.1 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.2 | 3.1 | GO:1901612 | cardiolipin binding(GO:1901612) |
| 0.2 | 1.8 | GO:0000155 | phosphorelay sensor kinase activity(GO:0000155) |
| 0.2 | 1.1 | GO:0004743 | pyruvate kinase activity(GO:0004743) |
| 0.2 | 4.1 | GO:0008432 | JUN kinase binding(GO:0008432) |
| 0.2 | 2.7 | GO:0045159 | myosin II binding(GO:0045159) |
| 0.2 | 3.5 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) |
| 0.1 | 1.9 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 0.1 | 7.5 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.1 | 3.1 | GO:0008430 | selenium binding(GO:0008430) |
| 0.1 | 1.3 | GO:0003872 | 6-phosphofructokinase activity(GO:0003872) |
| 0.1 | 0.8 | GO:0034714 | type III transforming growth factor beta receptor binding(GO:0034714) |
| 0.1 | 0.7 | GO:0044736 | acid-sensing ion channel activity(GO:0044736) |
| 0.1 | 0.5 | GO:0008431 | vitamin E binding(GO:0008431) |
| 0.1 | 3.1 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 0.1 | 0.8 | GO:0050610 | glutathione dehydrogenase (ascorbate) activity(GO:0045174) methylarsonate reductase activity(GO:0050610) |
| 0.1 | 4.0 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 0.1 | 1.5 | GO:0015272 | ATP-activated inward rectifier potassium channel activity(GO:0015272) |
| 0.1 | 5.2 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.1 | 0.5 | GO:0050508 | glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508) |
| 0.1 | 1.2 | GO:0008131 | primary amine oxidase activity(GO:0008131) |
| 0.1 | 0.4 | GO:0001641 | group II metabotropic glutamate receptor activity(GO:0001641) |
| 0.1 | 16.5 | GO:0051219 | phosphoprotein binding(GO:0051219) |
| 0.1 | 1.7 | GO:0003996 | acyl-CoA ligase activity(GO:0003996) |
| 0.1 | 0.5 | GO:0019776 | Atg8 ligase activity(GO:0019776) |
| 0.1 | 6.5 | GO:0042379 | chemokine receptor binding(GO:0042379) |
| 0.1 | 0.5 | GO:0015349 | thyroid hormone transmembrane transporter activity(GO:0015349) |
| 0.1 | 1.2 | GO:0052658 | inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) |
| 0.1 | 0.3 | GO:1990175 | EH domain binding(GO:1990175) |
| 0.1 | 16.0 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.1 | 0.7 | GO:0016454 | serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454) |
| 0.1 | 3.2 | GO:0001968 | fibronectin binding(GO:0001968) |
| 0.1 | 0.6 | GO:0038052 | RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052) |
| 0.1 | 0.4 | GO:0050501 | hyaluronan synthase activity(GO:0050501) |
| 0.1 | 0.5 | GO:0072345 | NAADP-sensitive calcium-release channel activity(GO:0072345) |
| 0.1 | 2.3 | GO:0001848 | complement binding(GO:0001848) |
| 0.1 | 3.8 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.1 | 0.3 | GO:0035241 | protein-arginine omega-N monomethyltransferase activity(GO:0035241) |
| 0.1 | 0.9 | GO:0070290 | N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290) |
| 0.1 | 0.9 | GO:0035612 | AP-2 adaptor complex binding(GO:0035612) |
| 0.1 | 0.7 | GO:0071532 | ankyrin repeat binding(GO:0071532) |
| 0.1 | 1.1 | GO:0022889 | L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889) |
| 0.1 | 3.6 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.1 | 0.2 | GO:0098973 | structural constituent of synapse(GO:0098918) structural constituent of postsynaptic actin cytoskeleton(GO:0098973) |
| 0.1 | 0.3 | GO:0017095 | heparan sulfate 6-O-sulfotransferase activity(GO:0017095) |
| 0.1 | 5.3 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.1 | 1.7 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.1 | 2.5 | GO:0030506 | ankyrin binding(GO:0030506) |
| 0.1 | 1.3 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) |
| 0.0 | 1.4 | GO:0050431 | transforming growth factor beta binding(GO:0050431) |
| 0.0 | 0.6 | GO:0008142 | oxysterol binding(GO:0008142) |
| 0.0 | 0.5 | GO:0005138 | interleukin-6 receptor binding(GO:0005138) |
| 0.0 | 3.0 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 0.0 | 10.2 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 1.8 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
| 0.0 | 0.7 | GO:0019531 | oxalate transmembrane transporter activity(GO:0019531) |
| 0.0 | 2.0 | GO:0004890 | GABA-A receptor activity(GO:0004890) |
| 0.0 | 0.1 | GO:0036328 | VEGF-C-activated receptor activity(GO:0036328) |
| 0.0 | 0.8 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.0 | 0.4 | GO:0016286 | small conductance calcium-activated potassium channel activity(GO:0016286) |
| 0.0 | 1.2 | GO:0005337 | nucleoside transmembrane transporter activity(GO:0005337) |
| 0.0 | 0.6 | GO:0070492 | oligosaccharide binding(GO:0070492) |
| 0.0 | 0.0 | GO:0051185 | coenzyme transporter activity(GO:0051185) |
| 0.0 | 0.5 | GO:0005004 | GPI-linked ephrin receptor activity(GO:0005004) |
| 0.0 | 3.7 | GO:0030295 | protein kinase activator activity(GO:0030295) |
| 0.0 | 1.2 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.0 | 1.1 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.0 | 4.0 | GO:0019838 | growth factor binding(GO:0019838) |
| 0.0 | 0.1 | GO:0032427 | GBD domain binding(GO:0032427) |
| 0.0 | 0.4 | GO:0015037 | peptide disulfide oxidoreductase activity(GO:0015037) |
| 0.0 | 0.2 | GO:0004459 | L-lactate dehydrogenase activity(GO:0004459) |
| 0.0 | 0.1 | GO:0003985 | acetyl-CoA C-acetyltransferase activity(GO:0003985) |
| 0.0 | 0.8 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.0 | 0.8 | GO:0019706 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.0 | 1.3 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 1.2 | GO:0008028 | monocarboxylic acid transmembrane transporter activity(GO:0008028) |
| 0.0 | 0.5 | GO:0010181 | FMN binding(GO:0010181) |
| 0.0 | 1.4 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.0 | 0.1 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
| 0.0 | 0.4 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.0 | 0.4 | GO:0019871 | sodium channel inhibitor activity(GO:0019871) |
| 0.0 | 0.4 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.0 | 0.4 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
| 0.0 | 0.7 | GO:0000146 | microfilament motor activity(GO:0000146) |
| 0.0 | 0.5 | GO:0005229 | intracellular calcium activated chloride channel activity(GO:0005229) |
| 0.0 | 1.8 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 1.0 | GO:0097110 | scaffold protein binding(GO:0097110) |
| 0.0 | 0.3 | GO:0019841 | retinol binding(GO:0019841) |
| 0.0 | 0.8 | GO:0035254 | glutamate receptor binding(GO:0035254) |
| 0.0 | 0.2 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.0 | 3.0 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.0 | 0.1 | GO:0015280 | ligand-gated sodium channel activity(GO:0015280) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 5.9 | ST STAT3 PATHWAY | STAT3 Pathway |
| 0.3 | 15.4 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.2 | 14.0 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.2 | 9.2 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.2 | 7.8 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 0.2 | 2.8 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.2 | 5.7 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.1 | 8.8 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 9.4 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 3.7 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.1 | 25.1 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 3.7 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.1 | 12.8 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 5.3 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 3.4 | PID ERBB1 RECEPTOR PROXIMAL PATHWAY | EGF receptor (ErbB1) signaling pathway |
| 0.1 | 3.7 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.1 | 5.5 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.1 | 3.3 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.0 | 2.0 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.0 | 0.8 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 16.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 2.6 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 4.5 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 2.9 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 0.9 | PID LYSOPHOSPHOLIPID PATHWAY | LPA receptor mediated events |
| 0.0 | 1.1 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.0 | 1.4 | ST P38 MAPK PATHWAY | p38 MAPK Pathway |
| 0.0 | 7.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 1.9 | PID ENDOTHELIN PATHWAY | Endothelins |
| 0.0 | 1.3 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 1.6 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 1.1 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.0 | 0.1 | PID LYMPH ANGIOGENESIS PATHWAY | VEGFR3 signaling in lymphatic endothelium |
| 0.0 | 1.3 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 0.5 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.0 | 0.9 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 1.0 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.0 | 1.1 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 0.5 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 1.7 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 21.3 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.4 | 12.5 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.3 | 8.2 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.3 | 5.9 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |
| 0.2 | 3.5 | REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the late endosome membrane |
| 0.2 | 4.6 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.2 | 4.1 | REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS | Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins |
| 0.1 | 7.5 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.1 | 5.7 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.1 | 5.1 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.1 | 6.7 | REACTOME AMINE COMPOUND SLC TRANSPORTERS | Genes involved in Amine compound SLC transporters |
| 0.1 | 2.4 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 23.2 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 3.4 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.1 | 10.2 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.1 | 1.1 | REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.1 | 9.0 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 2.5 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 13.6 | REACTOME SIGNALING BY PDGF | Genes involved in Signaling by PDGF |
| 0.1 | 10.4 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 1.3 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.1 | 3.2 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 5.7 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.1 | 1.8 | REACTOME PLC BETA MEDIATED EVENTS | Genes involved in PLC beta mediated events |
| 0.1 | 0.7 | REACTOME GAB1 SIGNALOSOME | Genes involved in GAB1 signalosome |
| 0.1 | 2.5 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.1 | 1.5 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.0 | 2.0 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.0 | 1.8 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.0 | 2.8 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.0 | 4.5 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 0.4 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.0 | 1.2 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.0 | 0.5 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.0 | 0.4 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.0 | 1.7 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 1.5 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 1.0 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.0 | 1.0 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.0 | 0.7 | REACTOME SIGNALING BY EGFR IN CANCER | Genes involved in Signaling by EGFR in Cancer |
| 0.0 | 0.7 | REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC | Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC |
| 0.0 | 0.8 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.0 | 1.3 | REACTOME NUCLEAR SIGNALING BY ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
| 0.0 | 1.0 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 0.4 | REACTOME EXTRACELLULAR MATRIX ORGANIZATION | Genes involved in Extracellular matrix organization |
| 0.0 | 0.7 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.0 | 0.7 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 0.7 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.0 | 1.1 | REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 0.0 | 0.3 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.0 | 0.3 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.0 | 1.2 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |