Motif ID: Nr6a1

Z-value: 0.667


Transcription factors associated with Nr6a1:

Gene SymbolEntrez IDGene Name
Nr6a1 ENSMUSG00000063972.7 Nr6a1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr6a1mm10_v2_chr2_-_38926217_38926454-0.312.1e-01Click!


Activity profile for motif Nr6a1.

activity profile for motif Nr6a1


Sorted Z-values histogram for motif Nr6a1

Sorted Z-values for motif Nr6a1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr6a1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_172472512 2.058 ENSMUST00000029007.2
Fam209
family with sequence similarity 209
chr7_-_66427469 1.449 ENSMUST00000015278.7
Aldh1a3
aldehyde dehydrogenase family 1, subfamily A3
chr6_+_83349446 1.363 ENSMUST00000136501.1
Bola3
bolA-like 3 (E. coli)
chr13_-_24761440 1.290 ENSMUST00000176890.1
ENSMUST00000175689.1
Gmnn

geminin

chr12_+_3807017 1.173 ENSMUST00000020991.8
ENSMUST00000172509.1
Dnmt3a

DNA methyltransferase 3A

chr12_-_115790884 1.141 ENSMUST00000081809.5
Ighv1-73
immunoglobulin heavy variable 1-73
chr14_+_12189943 1.121 ENSMUST00000119888.1
Ptprg
protein tyrosine phosphatase, receptor type, G
chr11_-_60811228 1.112 ENSMUST00000018744.8
Shmt1
serine hydroxymethyltransferase 1 (soluble)
chr7_+_30314810 1.096 ENSMUST00000054594.8
ENSMUST00000177078.1
ENSMUST00000176504.1
ENSMUST00000176304.1
Syne4



spectrin repeat containing, nuclear envelope family member 4



chr19_+_46707443 1.087 ENSMUST00000003655.7
As3mt
arsenic (+3 oxidation state) methyltransferase
chr6_+_42245907 1.070 ENSMUST00000031897.5
Gstk1
glutathione S-transferase kappa 1
chr12_+_3807076 1.051 ENSMUST00000174817.1
Dnmt3a
DNA methyltransferase 3A
chr15_-_98165613 0.968 ENSMUST00000143400.1
Asb8
ankyrin repeat and SOCS box-containing 8
chr4_-_45530330 0.959 ENSMUST00000061986.5
Shb
src homology 2 domain-containing transforming protein B
chr9_+_50603892 0.934 ENSMUST00000044051.4
Timm8b
translocase of inner mitochondrial membrane 8B
chr17_+_26123514 0.918 ENSMUST00000025014.8
Mrpl28
mitochondrial ribosomal protein L28
chr9_-_50603792 0.899 ENSMUST00000000175.4
Sdhd
succinate dehydrogenase complex, subunit D, integral membrane protein
chr18_-_77767752 0.896 ENSMUST00000048192.7
Haus1
HAUS augmin-like complex, subunit 1
chr14_+_58072686 0.828 ENSMUST00000022545.7
Fgf9
fibroblast growth factor 9
chr1_+_131970589 0.828 ENSMUST00000027695.6
Slc45a3
solute carrier family 45, member 3
chr11_-_69822144 0.813 ENSMUST00000045771.6
Spem1
sperm maturation 1
chr9_+_98296556 0.747 ENSMUST00000035031.6
ENSMUST00000112935.1
Nmnat3

nicotinamide nucleotide adenylyltransferase 3

chr10_+_128083273 0.744 ENSMUST00000026459.5
Atp5b
ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit
chr5_-_30073554 0.728 ENSMUST00000026846.6
Tyms
thymidylate synthase
chr12_-_71136611 0.687 ENSMUST00000021486.8
ENSMUST00000166120.1
Timm9

translocase of inner mitochondrial membrane 9

chr5_-_137611372 0.687 ENSMUST00000054564.6
Pcolce
procollagen C-endopeptidase enhancer protein
chr9_-_121839460 0.686 ENSMUST00000135986.2
Ccdc13
coiled-coil domain containing 13
chr10_-_80855187 0.683 ENSMUST00000035775.8
Lsm7
LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr4_+_123904832 0.655 ENSMUST00000030400.7
Mycbp
c-myc binding protein
chr17_+_72918298 0.650 ENSMUST00000024857.6
Lbh
limb-bud and heart
chr2_+_180071793 0.630 ENSMUST00000108901.1
Mtg2
mitochondrial ribosome associated GTPase 2
chr8_+_75109528 0.607 ENSMUST00000164309.1
Mcm5
minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
chr15_-_98165560 0.605 ENSMUST00000123922.1
Asb8
ankyrin repeat and SOCS box-containing 8
chr4_-_125065603 0.565 ENSMUST00000036383.3
Dnali1
dynein, axonemal, light intermediate polypeptide 1
chr5_-_5694024 0.533 ENSMUST00000115425.2
ENSMUST00000115427.1
ENSMUST00000115424.2
ENSMUST00000015797.4
Steap2



six transmembrane epithelial antigen of prostate 2



chr3_+_138526174 0.522 ENSMUST00000029803.7
Eif4e
eukaryotic translation initiation factor 4E
chr9_-_96437434 0.450 ENSMUST00000070500.2
BC043934
cDNA sequence BC043934
chr5_-_136986829 0.445 ENSMUST00000034953.7
ENSMUST00000085941.5
Znhit1

zinc finger, HIT domain containing 1

chr5_-_137610626 0.435 ENSMUST00000142675.1
Pcolce
procollagen C-endopeptidase enhancer protein
chr1_+_151428612 0.411 ENSMUST00000065625.5
Trmt1l
tRNA methyltransferase 1 like
chr10_-_43540945 0.409 ENSMUST00000147196.1
ENSMUST00000019932.3
1700021F05Rik

RIKEN cDNA 1700021F05 gene

chr5_-_137611429 0.396 ENSMUST00000031731.7
Pcolce
procollagen C-endopeptidase enhancer protein
chr2_+_157424255 0.390 ENSMUST00000029175.7
ENSMUST00000092576.4
Src

Rous sarcoma oncogene

chr11_+_6560183 0.376 ENSMUST00000109722.2
Ccm2
cerebral cavernous malformation 2
chr4_+_123904907 0.319 ENSMUST00000106202.3
Mycbp
c-myc binding protein
chr7_-_105574324 0.310 ENSMUST00000081165.7
Apbb1
amyloid beta (A4) precursor protein-binding, family B, member 1
chr2_+_173737492 0.308 ENSMUST00000067530.4
Vapb
vesicle-associated membrane protein, associated protein B and C
chr1_+_171329376 0.306 ENSMUST00000111299.1
ENSMUST00000064950.4
Dedd

death effector domain-containing

chr5_-_5694559 0.297 ENSMUST00000115426.2
Steap2
six transmembrane epithelial antigen of prostate 2
chr9_+_73102398 0.294 ENSMUST00000174203.2
ENSMUST00000034737.6
ENSMUST00000173734.2
ENSMUST00000167514.1
Gm20509
Khdc3


predicted gene 20509
KH domain containing 3, subcortical maternal complex member


chr17_-_46645128 0.224 ENSMUST00000003642.6
Klc4
kinesin light chain 4
chr4_-_123904826 0.207 ENSMUST00000181292.1
Gm26606
predicted gene, 26606
chr7_+_128265675 0.207 ENSMUST00000118169.1
ENSMUST00000142841.1
Slc5a2

solute carrier family 5 (sodium/glucose cotransporter), member 2

chr15_-_73184840 0.190 ENSMUST00000044113.10
Ago2
argonaute RISC catalytic subunit 2
chr8_-_109693235 0.189 ENSMUST00000034164.4
Ist1
increased sodium tolerance 1 homolog (yeast)
chr1_-_151428440 0.170 ENSMUST00000064771.5
Swt1
SWT1 RNA endoribonuclease homolog (S. cerevisiae)
chr2_+_32606946 0.159 ENSMUST00000113290.1
St6galnac6
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr17_+_33629078 0.156 ENSMUST00000166627.1
ENSMUST00000073570.5
ENSMUST00000170225.1
Zfp414


zinc finger protein 414


chr9_-_119157055 0.148 ENSMUST00000010795.4
Acaa1b
acetyl-Coenzyme A acyltransferase 1B
chr11_+_120677226 0.129 ENSMUST00000129644.2
ENSMUST00000151160.1
Aspscr1

alveolar soft part sarcoma chromosome region, candidate 1 (human)

chr4_-_134552122 0.102 ENSMUST00000060435.6
Sepn1
selenoprotein N, 1
chr6_+_48593927 0.086 ENSMUST00000135151.1
Repin1
replication initiator 1
chr13_+_58281183 0.073 ENSMUST00000180882.1
ENSMUST00000180452.1
Gm26555

predicted gene, 26555

chr1_-_79858627 0.037 ENSMUST00000027467.4
Serpine2
serine (or cysteine) peptidase inhibitor, clade E, member 2
chr4_+_155562348 0.031 ENSMUST00000030939.7
Nadk
NAD kinase
chr2_+_32606979 0.012 ENSMUST00000113289.1
ENSMUST00000095044.3
St6galnac6

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0060166 olfactory pit development(GO:0060166)
0.5 1.8 GO:0046073 dTMP biosynthetic process(GO:0006231) dTMP metabolic process(GO:0046073)
0.3 2.2 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.3 0.8 GO:0015772 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.2 0.9 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.2 0.7 GO:0019355 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process(GO:0034627) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.2 0.7 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.2 0.8 GO:0098706 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.1 0.7 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.1 0.7 GO:1904672 regulation of somatic stem cell population maintenance(GO:1904672)
0.1 1.1 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.1 0.4 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180)
0.1 1.1 GO:0009404 toxin metabolic process(GO:0009404)
0.1 0.8 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.1 0.3 GO:0044830 modulation by host of viral RNA genome replication(GO:0044830)
0.1 0.8 GO:0060484 lung-associated mesenchyme development(GO:0060484)
0.1 0.2 GO:0009838 abscission(GO:0009838)
0.1 0.4 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.1 1.1 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 0.2 GO:1904659 glucose transmembrane transport(GO:1904659)
0.0 0.2 GO:0035087 siRNA loading onto RISC involved in RNA interference(GO:0035087)
0.0 0.6 GO:0044065 regulation of respiratory system process(GO:0044065)
0.0 0.5 GO:0071549 cellular response to dexamethasone stimulus(GO:0071549)
0.0 0.4 GO:0060837 blood vessel endothelial cell differentiation(GO:0060837)
0.0 0.1 GO:1901837 negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837)
0.0 1.1 GO:1901998 toxin transport(GO:1901998)
0.0 1.3 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.0 0.2 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 1.1 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.8 GO:0030317 sperm motility(GO:0030317)
0.0 0.6 GO:0006270 DNA replication initiation(GO:0006270)
0.0 0.6 GO:0003341 cilium movement(GO:0003341)
0.0 1.2 GO:0051225 spindle assembly(GO:0051225)
0.0 0.7 GO:0031122 cytoplasmic microtubule organization(GO:0031122)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0045283 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.1 0.7 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.1 0.9 GO:0070652 HAUS complex(GO:0070652)
0.1 1.1 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 0.7 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.1 0.7 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.1 2.2 GO:0001741 XY body(GO:0001741)
0.1 0.5 GO:0033391 eukaryotic translation initiation factor 4F complex(GO:0016281) chromatoid body(GO:0033391)
0.1 1.1 GO:0044453 nuclear membrane part(GO:0044453)
0.1 0.3 GO:1990761 growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812)
0.0 0.3 GO:0045179 apical cortex(GO:0045179)
0.0 0.6 GO:0042555 MCM complex(GO:0042555)
0.0 0.4 GO:0000812 Swr1 complex(GO:0000812)
0.0 0.8 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 0.7 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.2 GO:0070578 RISC-loading complex(GO:0070578)
0.0 0.2 GO:0090543 Flemming body(GO:0090543)
0.0 1.5 GO:0000313 organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0008732 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) serine binding(GO:0070905)
0.4 1.4 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.3 0.9 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
0.3 2.2 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.3 0.8 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.3 0.8 GO:0008515 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.2 0.7 GO:0004515 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.1 0.7 GO:0043532 angiostatin binding(GO:0043532)
0.1 0.4 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.1 1.1 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 0.7 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.1 0.7 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.1 1.1 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.0 0.6 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.4 GO:0071253 connexin binding(GO:0071253)
0.0 0.8 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.6 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 1.5 GO:0016504 peptidase activator activity(GO:0016504)
0.0 1.0 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 1.3 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 0.2 GO:0005355 glucose transmembrane transporter activity(GO:0005355)
0.0 0.3 GO:0070064 proline-rich region binding(GO:0070064)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 2.2 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.4 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 1.6 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.8 PID_FGF_PATHWAY FGF signaling pathway
0.0 0.4 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 1.0 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 0.7 PID_E2F_PATHWAY E2F transcription factor network
0.0 1.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.1 1.3 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.0 0.7 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 0.9 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 2.4 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.6 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.5 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 1.9 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.4 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 1.4 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation