Motif ID: Sox4
Z-value: 0.487

Transcription factors associated with Sox4:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Sox4 | ENSMUSG00000076431.4 | Sox4 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Sox4 | mm10_v2_chr13_-_28953690_28953713 | -0.49 | 4.0e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 3.1 | GO:0015671 | oxygen transport(GO:0015671) |
0.4 | 1.1 | GO:0032696 | negative regulation of interleukin-13 production(GO:0032696) trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) odontoblast differentiation(GO:0071895) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899) |
0.2 | 0.7 | GO:0007161 | calcium-independent cell-matrix adhesion(GO:0007161) |
0.1 | 0.5 | GO:0072137 | condensed mesenchymal cell proliferation(GO:0072137) |
0.1 | 2.1 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
0.1 | 0.7 | GO:1903300 | negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300) |
0.1 | 0.3 | GO:1903334 | positive regulation of protein folding(GO:1903334) |
0.1 | 0.4 | GO:0003365 | establishment of cell polarity involved in ameboidal cell migration(GO:0003365) |
0.1 | 1.2 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
0.1 | 0.9 | GO:1990845 | adaptive thermogenesis(GO:1990845) |
0.1 | 0.6 | GO:0072513 | positive regulation of secondary heart field cardioblast proliferation(GO:0072513) |
0.1 | 0.3 | GO:0060244 | negative regulation of cell proliferation involved in contact inhibition(GO:0060244) |
0.1 | 0.3 | GO:0048496 | maintenance of organ identity(GO:0048496) |
0.1 | 0.3 | GO:0060217 | hemangioblast cell differentiation(GO:0060217) |
0.1 | 0.2 | GO:0001705 | ectoderm formation(GO:0001705) |
0.1 | 0.8 | GO:0035873 | lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879) |
0.1 | 0.2 | GO:1904059 | regulation of locomotor rhythm(GO:1904059) |
0.1 | 0.2 | GO:1903490 | regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490) |
0.1 | 0.3 | GO:0045578 | negative regulation of B cell differentiation(GO:0045578) |
0.1 | 0.2 | GO:0002331 | pre-B cell allelic exclusion(GO:0002331) |
0.1 | 1.2 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
0.1 | 1.2 | GO:0048368 | lateral mesoderm development(GO:0048368) |
0.1 | 0.2 | GO:0031660 | regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662) |
0.0 | 0.8 | GO:0070307 | lens fiber cell development(GO:0070307) |
0.0 | 0.6 | GO:0007213 | G-protein coupled acetylcholine receptor signaling pathway(GO:0007213) |
0.0 | 0.6 | GO:0021798 | forebrain dorsal/ventral pattern formation(GO:0021798) |
0.0 | 0.3 | GO:0031642 | negative regulation of myelination(GO:0031642) |
0.0 | 0.3 | GO:0050882 | voluntary musculoskeletal movement(GO:0050882) |
0.0 | 0.5 | GO:0000212 | meiotic spindle organization(GO:0000212) |
0.0 | 0.1 | GO:0060709 | glycogen cell differentiation involved in embryonic placenta development(GO:0060709) |
0.0 | 0.1 | GO:0033484 | nitric oxide homeostasis(GO:0033484) |
0.0 | 0.6 | GO:0050774 | negative regulation of dendrite morphogenesis(GO:0050774) |
0.0 | 0.5 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
0.0 | 0.1 | GO:0046671 | negative regulation of retinal cell programmed cell death(GO:0046671) |
0.0 | 0.4 | GO:0046697 | decidualization(GO:0046697) |
0.0 | 0.1 | GO:1904207 | chemokine (C-C motif) ligand 2 secretion(GO:0035926) regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209) |
0.0 | 0.2 | GO:0045721 | negative regulation of gluconeogenesis(GO:0045721) |
0.0 | 0.1 | GO:1903756 | regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758) |
0.0 | 0.1 | GO:0034392 | negative regulation of smooth muscle cell apoptotic process(GO:0034392) follicle-stimulating hormone signaling pathway(GO:0042699) |
0.0 | 0.5 | GO:0043171 | peptide catabolic process(GO:0043171) |
0.0 | 0.1 | GO:1904953 | Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation(GO:1904953) |
0.0 | 0.7 | GO:0035082 | axoneme assembly(GO:0035082) |
0.0 | 0.2 | GO:0031274 | positive regulation of pseudopodium assembly(GO:0031274) |
0.0 | 0.3 | GO:0035855 | megakaryocyte development(GO:0035855) |
0.0 | 0.3 | GO:0032967 | positive regulation of collagen biosynthetic process(GO:0032967) |
0.0 | 0.2 | GO:0061525 | hindgut development(GO:0061525) |
0.0 | 0.3 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 1.2 | GO:0071149 | TEAD-2-YAP complex(GO:0071149) |
0.4 | 3.1 | GO:0005833 | hemoglobin complex(GO:0005833) |
0.3 | 1.2 | GO:0008623 | CHRAC(GO:0008623) |
0.2 | 0.6 | GO:0031680 | G-protein beta/gamma-subunit complex(GO:0031680) |
0.1 | 0.3 | GO:0038045 | large latent transforming growth factor-beta complex(GO:0038045) |
0.1 | 0.5 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
0.1 | 1.1 | GO:1990907 | beta-catenin-TCF complex(GO:1990907) |
0.1 | 0.3 | GO:0097543 | ciliary inversin compartment(GO:0097543) |
0.1 | 0.3 | GO:0033193 | Lsd1/2 complex(GO:0033193) |
0.0 | 0.3 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
0.0 | 0.3 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
0.0 | 0.2 | GO:1990023 | mitotic spindle midzone(GO:1990023) |
0.0 | 0.6 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
0.0 | 0.7 | GO:0005882 | intermediate filament(GO:0005882) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.8 | 3.1 | GO:0031721 | hemoglobin alpha binding(GO:0031721) |
0.2 | 0.9 | GO:0017077 | oxidative phosphorylation uncoupler activity(GO:0017077) |
0.2 | 1.1 | GO:0030284 | estrogen receptor activity(GO:0030284) |
0.2 | 0.5 | GO:0030368 | interleukin-17 receptor activity(GO:0030368) |
0.1 | 1.2 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
0.1 | 0.5 | GO:0008240 | tripeptidyl-peptidase activity(GO:0008240) |
0.1 | 0.5 | GO:0061731 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
0.1 | 2.1 | GO:0070410 | co-SMAD binding(GO:0070410) |
0.1 | 0.4 | GO:0004921 | interleukin-11 receptor activity(GO:0004921) interleukin-11 binding(GO:0019970) |
0.1 | 0.8 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
0.1 | 0.4 | GO:0043532 | angiostatin binding(GO:0043532) |
0.1 | 0.3 | GO:0050436 | microfibril binding(GO:0050436) |
0.1 | 1.2 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
0.1 | 1.2 | GO:0001134 | transcription factor activity, transcription factor recruiting(GO:0001134) |
0.0 | 0.3 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) |
0.0 | 0.3 | GO:0046790 | virion binding(GO:0046790) |
0.0 | 0.1 | GO:0031826 | type 2A serotonin receptor binding(GO:0031826) |
0.0 | 0.3 | GO:0015037 | peptide disulfide oxidoreductase activity(GO:0015037) |
0.0 | 0.2 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
0.0 | 0.2 | GO:0031730 | CCR5 chemokine receptor binding(GO:0031730) |
0.0 | 0.6 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
0.0 | 0.2 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
0.0 | 0.1 | GO:0047184 | 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 1.2 | ST_ERK1_ERK2_MAPK_PATHWAY | ERK1/ERK2 MAPK Pathway |
0.0 | 2.2 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
0.0 | 0.9 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
0.0 | 1.6 | PID_CMYB_PATHWAY | C-MYB transcription factor network |
0.0 | 0.6 | PID_RHOA_PATHWAY | RhoA signaling pathway |
0.0 | 0.4 | PID_WNT_NONCANONICAL_PATHWAY | Noncanonical Wnt signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 2.1 | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
0.0 | 1.2 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
0.0 | 0.5 | REACTOME_G1_S_SPECIFIC_TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
0.0 | 0.2 | REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
0.0 | 0.3 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
0.0 | 0.6 | REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA | Genes involved in G beta:gamma signalling through PLC beta |
0.0 | 0.3 | REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
0.0 | 0.4 | REACTOME_SIGNALING_BY_HIPPO | Genes involved in Signaling by Hippo |
0.0 | 0.9 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |