Motif ID: Foxo4

Z-value: 0.998


Transcription factors associated with Foxo4:

Gene SymbolEntrez IDGene Name
Foxo4 ENSMUSG00000042903.7 Foxo4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxo4mm10_v2_chrX_+_101254528_101254574-0.077.9e-01Click!


Activity profile for motif Foxo4.

activity profile for motif Foxo4


Sorted Z-values histogram for motif Foxo4

Sorted Z-values for motif Foxo4



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxo4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_5796924 5.331 ENSMUST00000174808.1
Malat1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chr2_-_175338197 1.688 ENSMUST00000121393.2
Gm4631
predicted gene 4631
chr2_-_175931051 1.343 ENSMUST00000108949.2
ENSMUST00000109018.2
Gm8898

predicted gene 8898

chr2_-_175141999 1.289 ENSMUST00000109062.1
ENSMUST00000109059.1
ENSMUST00000109060.1
Gm14399


predicted gene 14399


chr7_-_4778141 1.176 ENSMUST00000094892.5
Il11
interleukin 11
chr17_-_23745829 1.157 ENSMUST00000046525.8
Kremen2
kringle containing transmembrane protein 2
chr2_+_176521056 1.124 ENSMUST00000108997.2
ENSMUST00000178443.1
Gm14431

predicted gene 14431

chr10_-_53638269 1.103 ENSMUST00000164393.1
Fam184a
family with sequence similarity 184, member A
chr2_+_176226569 1.096 ENSMUST00000099009.2
ENSMUST00000136719.1
2210418O10Rik

RIKEN cDNA 2210418O10 gene

chr2_-_176927809 1.046 ENSMUST00000099007.2
Gm14296
predicted gene 14296
chr2_+_175372436 1.021 ENSMUST00000131676.1
ENSMUST00000109048.2
ENSMUST00000109047.2
Gm4723


predicted gene 4723


chr2_-_177957239 0.992 ENSMUST00000108928.1
ENSMUST00000108932.1
ENSMUST00000108930.2
Gm14326


predicted gene 14326


chr2_-_175703646 0.982 ENSMUST00000109027.2
ENSMUST00000179061.1
ENSMUST00000131041.1
Gm4245


predicted gene 4245


chr2_+_175469985 0.932 ENSMUST00000109042.3
ENSMUST00000109002.2
ENSMUST00000109043.2
ENSMUST00000143490.1
Gm8923



predicted gene 8923



chr6_+_42286676 0.898 ENSMUST00000031894.6
Clcn1
chloride channel 1
chr2_-_175206899 0.880 ENSMUST00000109055.1
ENSMUST00000099028.3
ENSMUST00000109056.1
ENSMUST00000109058.2
Gm14391



predicted gene 14391



chr8_+_26119361 0.871 ENSMUST00000014022.8
ENSMUST00000153528.1
ENSMUST00000131138.1
ENSMUST00000110575.1
Rnf170



ring finger protein 170



chr2_+_176670522 0.870 ENSMUST00000121956.1
ENSMUST00000108985.2
Gm14306

predicted gene 14306

chr11_-_77078404 0.816 ENSMUST00000102494.1
Ccdc55
coiled-coil domain containing 55
chr2_+_178023284 0.790 ENSMUST00000108925.3
ENSMUST00000108926.2
Etohi1

ethanol induced 1

chr5_+_139543889 0.788 ENSMUST00000174792.1
ENSMUST00000031523.8
Uncx

UNC homeobox

chr17_+_26202946 0.783 ENSMUST00000122058.1
ENSMUST00000025020.5
Rgs11

regulator of G-protein signaling 11

chr8_+_26119611 0.763 ENSMUST00000140819.1
Rnf170
ring finger protein 170
chr6_+_42286709 0.762 ENSMUST00000163936.1
Clcn1
chloride channel 1
chr8_+_79639618 0.749 ENSMUST00000173078.1
ENSMUST00000173286.1
Otud4

OTU domain containing 4

chr2_+_175965331 0.714 ENSMUST00000109007.1
ENSMUST00000174416.1
Gm2026

predicted gene 2026

chr8_-_105943382 0.662 ENSMUST00000038896.7
Lcat
lecithin cholesterol acyltransferase
chr2_-_178078425 0.634 ENSMUST00000108924.2
ENSMUST00000131702.1
ENSMUST00000108923.1
Zfp931


zinc finger protein 931


chr7_-_4524229 0.587 ENSMUST00000154913.1
Tnni3
troponin I, cardiac 3
chr7_-_103813913 0.585 ENSMUST00000098192.3
Hbb-bt
hemoglobin, beta adult t chain
chrX_+_85574018 0.571 ENSMUST00000048250.3
ENSMUST00000137438.1
ENSMUST00000146063.1
Tab3


TGF-beta activated kinase 1/MAP3K7 binding protein 3


chr1_+_171437535 0.551 ENSMUST00000043839.4
F11r
F11 receptor
chr6_+_95117740 0.521 ENSMUST00000032107.7
ENSMUST00000119582.1
Kbtbd8

kelch repeat and BTB (POZ) domain containing 8

chr2_+_177000956 0.517 ENSMUST00000108975.2
ENSMUST00000156844.1
Gm14419

predicted gene 14419

chr2_-_177840318 0.508 ENSMUST00000108939.2
ENSMUST00000150650.1
Gm14325

predicted gene 14325

chr12_+_75308308 0.508 ENSMUST00000118602.1
ENSMUST00000118966.1
ENSMUST00000055390.5
Rhoj


ras homolog gene family, member J


chr1_+_6487231 0.470 ENSMUST00000140079.1
ENSMUST00000131494.1
St18

suppression of tumorigenicity 18

chr11_+_101246960 0.463 ENSMUST00000107282.3
Ramp2
receptor (calcitonin) activity modifying protein 2
chr2_+_175869219 0.458 ENSMUST00000109011.1
Gm6710
predicted gene 6710
chr8_+_70234613 0.456 ENSMUST00000145078.1
Sugp2
SURP and G patch domain containing 2
chr14_-_25903100 0.455 ENSMUST00000052286.8
Plac9a
placenta specific 9a
chr2_+_176708328 0.449 ENSMUST00000108981.2
ENSMUST00000108980.2
Gm14305

predicted gene 14305

chr14_-_26182480 0.431 ENSMUST00000184142.1
Plac9b
placenta specific 9b
chr11_-_85139939 0.414 ENSMUST00000108075.2
Usp32
ubiquitin specific peptidase 32
chr2_-_175435782 0.404 ENSMUST00000152941.1
ENSMUST00000109045.2
Gm4724

predicted gene 4724

chr2_-_176636318 0.395 ENSMUST00000108990.2
ENSMUST00000119149.1
ENSMUST00000117267.1
Gm14308


predicted gene 14308


chr4_+_97777606 0.395 ENSMUST00000075448.6
ENSMUST00000092532.6
Nfia

nuclear factor I/A

chr5_-_70842617 0.393 ENSMUST00000031119.1
Gabrg1
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1
chr2_-_176486773 0.379 ENSMUST00000120959.1
ENSMUST00000120521.1
Gm14434

predicted gene 14434

chr11_+_105589970 0.379 ENSMUST00000168598.1
ENSMUST00000100330.3
Tanc2

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2

chr2_+_176798612 0.359 ENSMUST00000118012.2
Gm14295
predicted gene 14295
chr18_-_38918642 0.352 ENSMUST00000040647.4
Fgf1
fibroblast growth factor 1
chr11_-_42182924 0.349 ENSMUST00000020707.5
ENSMUST00000132971.1
Gabra1

gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1

chr2_-_75938407 0.347 ENSMUST00000099996.3
Ttc30b
tetratricopeptide repeat domain 30B
chr7_-_3629874 0.334 ENSMUST00000155592.1
ENSMUST00000108641.3
Tfpt

TCF3 (E2A) fusion partner

chr15_-_97767798 0.328 ENSMUST00000129223.2
ENSMUST00000126854.2
ENSMUST00000135080.1
Rapgef3


Rap guanine nucleotide exchange factor (GEF) 3


chr15_-_80014808 0.287 ENSMUST00000000500.6
Pdgfb
platelet derived growth factor, B polypeptide
chr4_+_8690399 0.281 ENSMUST00000127476.1
Chd7
chromodomain helicase DNA binding protein 7
chr13_-_117025505 0.271 ENSMUST00000022239.6
Parp8
poly (ADP-ribose) polymerase family, member 8
chr18_-_6490808 0.258 ENSMUST00000028100.6
ENSMUST00000050542.5
Epc1

enhancer of polycomb homolog 1 (Drosophila)

chr12_-_69892989 0.219 ENSMUST00000110567.1
ENSMUST00000171211.1
Map4k5

mitogen-activated protein kinase kinase kinase kinase 5

chr10_-_40257648 0.210 ENSMUST00000019982.7
Gtf3c6
general transcription factor IIIC, polypeptide 6, alpha
chr2_-_177206421 0.203 ENSMUST00000108964.1
Gm14410
predicted gene 14410
chr2_-_144011202 0.192 ENSMUST00000016072.5
ENSMUST00000037875.5
Rrbp1

ribosome binding protein 1

chrX_-_166585679 0.187 ENSMUST00000000412.2
Egfl6
EGF-like-domain, multiple 6
chr5_+_37185897 0.184 ENSMUST00000094840.3
Gm1043
predicted gene 1043
chr8_-_45410539 0.174 ENSMUST00000034056.4
ENSMUST00000167106.1
Tlr3

toll-like receptor 3

chr15_-_35938009 0.143 ENSMUST00000156915.1
Cox6c
cytochrome c oxidase subunit VIc
chr11_-_83649349 0.126 ENSMUST00000001008.5
Ccl3
chemokine (C-C motif) ligand 3
chr11_-_102579461 0.121 ENSMUST00000107081.1
Gm11627
predicted gene 11627
chr1_+_171213969 0.117 ENSMUST00000005820.4
ENSMUST00000075469.5
ENSMUST00000155126.1
Nr1i3


nuclear receptor subfamily 1, group I, member 3


chr5_-_24445254 0.109 ENSMUST00000030800.6
Fastk
Fas-activated serine/threonine kinase
chr13_-_8940977 0.108 ENSMUST00000071184.2
Rpl10a-ps2
ribosomal protein L10A, pseudogene 2
chrX_+_7579666 0.099 ENSMUST00000115740.1
ENSMUST00000115739.1
Foxp3

forkhead box P3

chr7_-_133123770 0.089 ENSMUST00000164896.1
ENSMUST00000171968.1
Ctbp2

C-terminal binding protein 2

chr4_-_6454262 0.080 ENSMUST00000029910.5
Nsmaf
neutral sphingomyelinase (N-SMase) activation associated factor
chr6_-_128424883 0.078 ENSMUST00000001559.8
Itfg2
integrin alpha FG-GAP repeat containing 2
chr7_+_29303958 0.069 ENSMUST00000049977.6
Dpf1
D4, zinc and double PHD fingers family 1
chr2_-_45110336 0.062 ENSMUST00000028229.6
ENSMUST00000152232.1
Zeb2

zinc finger E-box binding homeobox 2

chr7_-_27355944 0.058 ENSMUST00000003857.6
Shkbp1
Sh3kbp1 binding protein 1
chr5_-_24445166 0.053 ENSMUST00000115043.1
ENSMUST00000115041.1
Fastk

Fas-activated serine/threonine kinase

chr16_-_64771146 0.038 ENSMUST00000076991.6
4930453N24Rik
RIKEN cDNA 4930453N24 gene
chr15_-_35938186 0.018 ENSMUST00000014457.8
Cox6c
cytochrome c oxidase subunit VIc
chr4_-_97778042 0.009 ENSMUST00000146447.1
E130114P18Rik
RIKEN cDNA E130114P18 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 5.3 GO:0035063 nuclear speck organization(GO:0035063)
0.2 1.7 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 0.7 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372)
0.1 0.4 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.1 0.8 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.1 0.6 GO:0001980 regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980)
0.1 0.3 GO:0003104 positive regulation of glomerular filtration(GO:0003104) negative regulation of phosphatidylinositol biosynthetic process(GO:0010512) phenotypic switching(GO:0036166) metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.1 0.3 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.1 0.3 GO:1904451 regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904451) positive regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904453)
0.1 0.5 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.1 0.2 GO:0045349 regulation of dendritic cell cytokine production(GO:0002730) interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of interferon-beta biosynthetic process(GO:0045359)
0.0 0.5 GO:0014029 neural crest formation(GO:0014029)
0.0 0.6 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.5 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.0 0.5 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0 0.3 GO:0071420 cellular response to histamine(GO:0071420)
0.0 0.1 GO:0032829 positive regulation of T cell anergy(GO:0002669) negative regulation of T cell cytokine production(GO:0002725) positive regulation of lymphocyte anergy(GO:0002913) regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829) negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.0 0.1 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.0 0.7 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.4 GO:0072189 ureter development(GO:0072189)
0.0 0.4 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.1 GO:0043615 astrocyte cell migration(GO:0043615)
0.0 1.2 GO:0046888 negative regulation of hormone secretion(GO:0046888)
0.0 1.2 GO:0030279 negative regulation of ossification(GO:0030279)
0.0 0.3 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.1 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:1990584 cardiac Troponin complex(GO:1990584)
0.1 0.6 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 0.5 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.1 0.3 GO:0097574 lateral part of cell(GO:0097574) basolateral part of cell(GO:1990794) rod bipolar cell terminal bouton(GO:1990795)
0.1 0.6 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 2.4 GO:0034707 chloride channel complex(GO:0034707)
0.1 0.3 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.8 GO:0044292 dendrite terminus(GO:0044292)
0.0 0.7 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.2 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.3 GO:0031011 Ino80 complex(GO:0031011)
0.0 0.3 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 5.0 GO:0016607 nuclear speck(GO:0016607)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0030172 troponin C binding(GO:0030172)
0.1 0.6 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.1 0.7 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.1 1.7 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 0.5 GO:0097643 amylin receptor activity(GO:0097643)
0.1 0.3 GO:1904315 GABA-gated chloride ion channel activity(GO:0022851) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0 0.8 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.3 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.3 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.4 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 0.4 GO:0044548 S100 protein binding(GO:0044548)
0.0 0.1 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.0 0.1 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.0 0.1 GO:0051525 NFAT protein binding(GO:0051525)
0.0 0.2 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.3 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 1.3 GO:0005125 cytokine activity(GO:0005125)
0.0 1.2 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.1 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 1.2 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.3 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.3 PID_S1P_S1P1_PATHWAY S1P1 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.1 0.7 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.4 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 0.2 REACTOME_TRAF6_MEDIATED_INDUCTION_OF_TAK1_COMPLEX Genes involved in TRAF6 mediated induction of TAK1 complex
0.0 0.6 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.6 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.3 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 0.1 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines