Motif ID: Cdc5l

Z-value: 1.136


Transcription factors associated with Cdc5l:

Gene SymbolEntrez IDGene Name
Cdc5l ENSMUSG00000023932.8 Cdc5l

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Cdc5lmm10_v2_chr17_-_45433682_45433709-0.233.6e-01Click!


Activity profile for motif Cdc5l.

activity profile for motif Cdc5l


Sorted Z-values histogram for motif Cdc5l

Sorted Z-values for motif Cdc5l



Network of associatons between targets according to the STRING database.



First level regulatory network of Cdc5l

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_65620829 4.381 ENSMUST00000028377.7
Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr5_+_107497762 4.182 ENSMUST00000152474.1
ENSMUST00000060553.7
A830010M20Rik

RIKEN cDNA A830010M20 gene

chr19_-_5797410 4.093 ENSMUST00000173314.1
Malat1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chr5_+_107497718 3.761 ENSMUST00000112671.2
A830010M20Rik
RIKEN cDNA A830010M20 gene
chr18_-_22850738 3.680 ENSMUST00000092015.4
ENSMUST00000069215.6
Nol4

nucleolar protein 4

chr12_+_29528382 3.661 ENSMUST00000049784.9
Myt1l
myelin transcription factor 1-like
chr9_-_112187898 3.341 ENSMUST00000178410.1
ENSMUST00000172380.3
Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr9_-_112187766 3.246 ENSMUST00000111872.2
ENSMUST00000164754.2
Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr18_-_31447383 2.647 ENSMUST00000025110.3
Syt4
synaptotagmin IV
chr9_-_55919605 2.365 ENSMUST00000037408.8
Scaper
S phase cyclin A-associated protein in the ER
chr5_+_66968559 2.185 ENSMUST00000127184.1
Limch1
LIM and calponin homology domains 1
chr2_-_72986716 2.084 ENSMUST00000112062.1
Gm11084
predicted gene 11084
chr11_-_50953745 2.050 ENSMUST00000162420.1
ENSMUST00000051159.2
Prop1

paired like homeodomain factor 1

chr12_+_74297474 2.046 ENSMUST00000072100.3
Dbpht2
DNA binding protein with his-thr domain
chrX_+_136822781 2.011 ENSMUST00000113085.1
Plp1
proteolipid protein (myelin) 1
chr1_+_180111339 1.971 ENSMUST00000145181.1
Cdc42bpa
CDC42 binding protein kinase alpha
chr9_-_96752822 1.822 ENSMUST00000152594.1
Zbtb38
zinc finger and BTB domain containing 38
chr17_-_78684262 1.800 ENSMUST00000145480.1
Strn
striatin, calmodulin binding protein
chrX_+_136822671 1.719 ENSMUST00000033800.6
Plp1
proteolipid protein (myelin) 1
chr5_+_66968416 1.530 ENSMUST00000038188.7
Limch1
LIM and calponin homology domains 1
chr6_+_86526271 1.293 ENSMUST00000180896.1
1600020E01Rik
RIKEN cDNA 1600020E01 gene
chr2_-_64975762 1.137 ENSMUST00000156765.1
Grb14
growth factor receptor bound protein 14
chr19_+_26749726 1.125 ENSMUST00000175842.1
Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr1_+_17601893 1.112 ENSMUST00000088476.2
Pi15
peptidase inhibitor 15
chr1_-_30863256 1.059 ENSMUST00000088310.3
Phf3
PHD finger protein 3
chrX_-_37104523 1.058 ENSMUST00000130324.1
Upf3b
UPF3 regulator of nonsense transcripts homolog B (yeast)
chr10_+_17723220 1.047 ENSMUST00000038107.7
Cited2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
chr1_+_143640664 0.840 ENSMUST00000038252.2
B3galt2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr4_-_149126688 0.830 ENSMUST00000030815.2
Cort
cortistatin
chr4_+_95967205 0.772 ENSMUST00000030306.7
Hook1
hook homolog 1 (Drosophila)
chr7_+_112742025 0.729 ENSMUST00000164363.1
Tead1
TEA domain family member 1
chr14_+_66635251 0.719 ENSMUST00000159365.1
ENSMUST00000054661.1
ENSMUST00000159068.1
Adra1a


adrenergic receptor, alpha 1a


chr10_-_127189981 0.671 ENSMUST00000019611.7
Arhgef25
Rho guanine nucleotide exchange factor (GEF) 25
chr7_-_103741322 0.634 ENSMUST00000051346.2
Olfr629
olfactory receptor 629
chr1_-_97761538 0.606 ENSMUST00000171129.1
Ppip5k2
diphosphoinositol pentakisphosphate kinase 2
chr3_-_49757257 0.308 ENSMUST00000035931.7
Pcdh18
protocadherin 18
chr5_-_31220491 0.275 ENSMUST00000031032.7
Ppm1g
protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform
chr4_-_119383732 0.037 ENSMUST00000044781.2
ENSMUST00000084307.3
Ccdc30

coiled-coil domain containing 30


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.1 GO:0035063 nuclear speck organization(GO:0035063)
0.7 2.1 GO:0060126 hypophysis morphogenesis(GO:0048850) somatotropin secreting cell differentiation(GO:0060126)
0.4 1.1 GO:1903538 meiotic cell cycle process involved in oocyte maturation(GO:1903537) regulation of meiotic cell cycle process involved in oocyte maturation(GO:1903538)
0.3 2.6 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.3 1.0 GO:0061428 embryonic heart tube left/right pattern formation(GO:0060971) negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428)
0.2 3.7 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.2 0.7 GO:0001978 regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback(GO:0001978)
0.1 1.1 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.1 6.6 GO:0034605 cellular response to heat(GO:0034605)
0.1 3.7 GO:0048665 neuron fate specification(GO:0048665)
0.1 0.8 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.1 2.0 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.1 0.7 GO:0014883 transition between fast and slow fiber(GO:0014883)
0.1 0.8 GO:0045187 regulation of circadian sleep/wake cycle, sleep(GO:0045187)
0.1 0.6 GO:0006020 inositol metabolic process(GO:0006020)
0.0 1.1 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 0.3 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.0 3.7 GO:0031032 actomyosin structure organization(GO:0031032)
0.0 0.8 GO:0008333 endosome to lysosome transport(GO:0008333)
0.0 0.3 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.2 2.6 GO:0097449 astrocyte projection(GO:0097449)
0.1 0.8 GO:0070695 FHF complex(GO:0070695)
0.1 1.8 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 1.1 GO:0071564 npBAF complex(GO:0071564)
0.0 1.1 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 1.8 GO:0072562 blood microparticle(GO:0072562)
0.0 2.0 GO:0042641 actomyosin(GO:0042641)
0.0 3.7 GO:0043209 myelin sheath(GO:0043209)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.6 GO:0030348 syntaxin-3 binding(GO:0030348)
0.5 3.7 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.3 3.7 GO:0050897 cobalt ion binding(GO:0050897)
0.2 0.7 GO:0004936 alpha-adrenergic receptor activity(GO:0004936)
0.2 0.8 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.2 2.1 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.2 0.6 GO:0000832 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.1 0.6 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 1.0 GO:0050693 LBD domain binding(GO:0050693)
0.1 1.8 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 1.8 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.8 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.7 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.0 6.6 GO:0005516 calmodulin binding(GO:0005516)
0.0 1.1 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.8 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.0 1.1 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.8 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling
0.0 1.0 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 1.1 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 2.0 PID_CDC42_PATHWAY CDC42 signaling events
0.0 0.7 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 1.1 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 1.1 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 1.1 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.0 0.7 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression