Motif ID: Relb

Z-value: 0.641


Transcription factors associated with Relb:

Gene SymbolEntrez IDGene Name
Relb ENSMUSG00000002983.10 Relb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Relbmm10_v2_chr7_-_19629355_196294510.643.9e-03Click!


Activity profile for motif Relb.

activity profile for motif Relb


Sorted Z-values histogram for motif Relb

Sorted Z-values for motif Relb



Network of associatons between targets according to the STRING database.



First level regulatory network of Relb

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_5714490 3.295 ENSMUST00000044009.7
Camk1d
calcium/calmodulin-dependent protein kinase ID
chr14_+_80000292 2.626 ENSMUST00000088735.3
Olfm4
olfactomedin 4
chr15_-_79164477 2.101 ENSMUST00000040019.4
Sox10
SRY-box containing gene 10
chr7_+_99535652 1.417 ENSMUST00000032995.8
ENSMUST00000162404.1
Arrb1

arrestin, beta 1

chr7_+_99535439 1.364 ENSMUST00000098266.2
ENSMUST00000179755.1
Arrb1

arrestin, beta 1

chr2_-_5063996 1.297 ENSMUST00000114996.1
Optn
optineurin
chr9_+_64385626 1.267 ENSMUST00000093829.2
ENSMUST00000118485.1
ENSMUST00000164113.1
Megf11


multiple EGF-like-domains 11


chr3_-_107760221 1.148 ENSMUST00000153114.1
ENSMUST00000118593.1
ENSMUST00000120243.1
Csf1


colony stimulating factor 1 (macrophage)


chr2_-_5063932 1.122 ENSMUST00000027986.4
Optn
optineurin
chr3_-_9610074 1.015 ENSMUST00000041124.7
Zfp704
zinc finger protein 704
chr5_+_150259922 0.967 ENSMUST00000087204.5
Fry
furry homolog (Drosophila)
chrX_+_163909132 0.918 ENSMUST00000033734.7
ENSMUST00000112294.2
Ap1s2

adaptor-related protein complex 1, sigma 2 subunit

chr9_+_64385675 0.907 ENSMUST00000068967.4
Megf11
multiple EGF-like-domains 11
chr18_+_36559972 0.887 ENSMUST00000134146.1
Ankhd1
ankyrin repeat and KH domain containing 1
chr13_+_83732438 0.877 ENSMUST00000182701.1
C130071C03Rik
RIKEN cDNA C130071C03 gene
chr7_+_43463145 0.849 ENSMUST00000107977.1
Vsig10l
ZV-set and immunoglobulin domain containing 10 like
chr5_+_90759299 0.789 ENSMUST00000031318.4
Cxcl5
chemokine (C-X-C motif) ligand 5
chrX_+_163908982 0.784 ENSMUST00000069041.8
Ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr18_+_37484955 0.764 ENSMUST00000053856.4
Pcdhb17
protocadherin beta 17
chr3_+_7612702 0.732 ENSMUST00000181286.1
Gm16685
predicted gene, 16685
chr12_+_102948843 0.719 ENSMUST00000101099.5
Unc79
unc-79 homolog (C. elegans)
chr18_+_36560581 0.651 ENSMUST00000155329.2
Ankhd1
ankyrin repeat and KH domain containing 1
chr1_+_15287259 0.645 ENSMUST00000175681.1
Kcnb2
potassium voltage gated channel, Shab-related subfamily, member 2
chr15_-_98677451 0.572 ENSMUST00000120997.1
ENSMUST00000109149.2
ENSMUST00000003451.4
Rnd1


Rho family GTPase 1


chr1_+_152399824 0.570 ENSMUST00000044311.8
Colgalt2
collagen beta(1-O)galactosyltransferase 2
chr4_+_114680769 0.510 ENSMUST00000146346.1
Gm12829
predicted gene 12829
chr2_+_119972699 0.482 ENSMUST00000066058.7
Mapkbp1
mitogen-activated protein kinase binding protein 1
chr16_+_97997313 0.461 ENSMUST00000122450.1
B230307C23Rik
RIKEN cDNA B230307C23 gene
chr7_+_28766747 0.460 ENSMUST00000170068.1
ENSMUST00000072965.4
Sirt2

sirtuin 2

chr7_-_19629355 0.429 ENSMUST00000049912.8
ENSMUST00000094762.3
ENSMUST00000098754.4
Relb


avian reticuloendotheliosis viral (v-rel) oncogene related B


chr4_+_43631935 0.415 ENSMUST00000030191.8
Npr2
natriuretic peptide receptor 2
chr16_+_32914094 0.405 ENSMUST00000023491.6
ENSMUST00000170899.1
ENSMUST00000171118.1
ENSMUST00000170201.1
ENSMUST00000165616.1
ENSMUST00000135193.2
Lrch3





leucine-rich repeats and calponin homology (CH) domain containing 3





chr15_-_89429093 0.394 ENSMUST00000170460.1
Chkb
choline kinase beta
chr16_-_55838827 0.388 ENSMUST00000096026.2
ENSMUST00000036273.6
ENSMUST00000114457.1
Nfkbiz


nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta


chr2_-_27027909 0.388 ENSMUST00000102890.4
ENSMUST00000153388.1
ENSMUST00000045702.5
Slc2a6


solute carrier family 2 (facilitated glucose transporter), member 6


chr4_-_101265236 0.381 ENSMUST00000149297.1
ENSMUST00000102781.3
Jak1

Janus kinase 1

chr4_-_148500449 0.371 ENSMUST00000030840.3
Angptl7
angiopoietin-like 7
chr14_+_55560480 0.367 ENSMUST00000121622.1
ENSMUST00000143431.1
ENSMUST00000150481.1
Dcaf11


DDB1 and CUL4 associated factor 11


chr2_+_10153563 0.365 ENSMUST00000026886.7
Itih5
inter-alpha (globulin) inhibitor H5
chr10_-_93310963 0.361 ENSMUST00000151153.1
Elk3
ELK3, member of ETS oncogene family
chr4_+_129985098 0.356 ENSMUST00000106017.1
ENSMUST00000121049.1
Bai2

brain-specific angiogenesis inhibitor 2

chr11_+_90030295 0.354 ENSMUST00000092788.3
Tmem100
transmembrane protein 100
chr7_+_16309577 0.344 ENSMUST00000002152.6
Bbc3
BCL2 binding component 3
chr10_-_19015347 0.337 ENSMUST00000019997.4
Tnfaip3
tumor necrosis factor, alpha-induced protein 3
chr15_-_33405976 0.321 ENSMUST00000079057.6
1700084J12Rik
RIKEN cDNA 1700084J12 gene
chr1_+_135132693 0.305 ENSMUST00000049449.4
Ptpn7
protein tyrosine phosphatase, non-receptor type 7
chr12_+_111538101 0.298 ENSMUST00000166123.1
Eif5
eukaryotic translation initiation factor 5
chr7_-_28766469 0.271 ENSMUST00000085851.5
ENSMUST00000032815.4
Nfkbib

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta

chr4_+_126262325 0.269 ENSMUST00000030660.8
Trappc3
trafficking protein particle complex 3
chr10_-_93311073 0.267 ENSMUST00000008542.5
Elk3
ELK3, member of ETS oncogene family
chr12_-_55492587 0.239 ENSMUST00000021413.7
Nfkbia
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
chr17_+_37193889 0.220 ENSMUST00000038844.6
Ubd
ubiquitin D
chr11_-_84870712 0.211 ENSMUST00000170741.1
ENSMUST00000172405.1
ENSMUST00000100686.3
ENSMUST00000108081.2
Ggnbp2



gametogenetin binding protein 2



chr4_+_129984833 0.204 ENSMUST00000120204.1
Bai2
brain-specific angiogenesis inhibitor 2
chr11_-_84870812 0.199 ENSMUST00000168434.1
Ggnbp2
gametogenetin binding protein 2
chr11_-_84870646 0.176 ENSMUST00000018547.2
Ggnbp2
gametogenetin binding protein 2
chr6_-_124741374 0.141 ENSMUST00000004389.5
Grcc10
gene rich cluster, C10 gene
chr12_+_111166485 0.141 ENSMUST00000139162.1
Traf3
TNF receptor-associated factor 3
chr1_+_135133272 0.122 ENSMUST00000167080.1
Ptpn7
protein tyrosine phosphatase, non-receptor type 7
chr11_-_84870188 0.088 ENSMUST00000154915.2
Ggnbp2
gametogenetin binding protein 2
chr17_+_35424842 0.072 ENSMUST00000174699.1
H2-Q6
histocompatibility 2, Q region locus 6
chr8_+_72319033 0.069 ENSMUST00000067912.7
Klf2
Kruppel-like factor 2 (lung)
chr10_-_77902467 0.062 ENSMUST00000057608.4
Lrrc3
leucine rich repeat containing 3
chr5_-_122989086 0.060 ENSMUST00000046073.9
Kdm2b
lysine (K)-specific demethylase 2B
chr4_-_40239779 0.058 ENSMUST00000037907.6
Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr4_-_40239700 0.011 ENSMUST00000142055.1
Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr12_-_76369586 0.011 ENSMUST00000176278.1
Zbtb25
zinc finger and BTB domain containing 25
chr5_-_122989260 0.008 ENSMUST00000118027.1
Kdm2b
lysine (K)-specific demethylase 2B
chr4_-_91399984 0.004 ENSMUST00000102799.3
Elavl2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.4 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.5 3.3 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.5 2.8 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.4 2.1 GO:0010626 negative regulation of Schwann cell proliferation(GO:0010626)
0.4 1.1 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.3 0.8 GO:0070944 neutrophil mediated killing of bacterium(GO:0070944)
0.2 0.5 GO:1900226 negative regulation of NLRP3 inflammasome complex assembly(GO:1900226)
0.1 0.7 GO:0033140 negative regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033140)
0.1 0.6 GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.1 1.0 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.1 0.5 GO:0007256 activation of JNKK activity(GO:0007256)
0.1 0.4 GO:0036015 response to interleukin-3(GO:0036015) cellular response to interleukin-3(GO:0036016)
0.1 0.3 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.1 0.7 GO:0048149 behavioral response to ethanol(GO:0048149)
0.1 2.2 GO:0010842 retina layer formation(GO:0010842)
0.1 0.4 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.1 2.6 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1 0.3 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.0 0.1 GO:0061744 motor behavior(GO:0061744)
0.0 0.6 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.0 0.4 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.0 0.4 GO:0060842 arterial endothelial cell differentiation(GO:0060842)
0.0 0.4 GO:0035428 hexose transmembrane transport(GO:0035428)
0.0 0.6 GO:0016322 neuron remodeling(GO:0016322)
0.0 1.7 GO:0060612 adipose tissue development(GO:0060612)
0.0 0.3 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.0 0.1 GO:0009597 detection of virus(GO:0009597)
0.0 0.4 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 0.1 GO:0071499 response to laminar fluid shear stress(GO:0034616) cellular response to laminar fluid shear stress(GO:0071499)
0.0 0.1 GO:0021993 initiation of neural tube closure(GO:0021993)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.3 2.1 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.2 2.6 GO:0042581 specific granule(GO:0042581)
0.2 2.8 GO:0031143 pseudopodium(GO:0031143)
0.1 0.5 GO:0033010 paranodal junction(GO:0033010)
0.0 0.3 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.5 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.4 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 1.7 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 0.3 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.6 GO:0032809 neuronal cell body membrane(GO:0032809)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.8 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.3 2.4 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.2 0.6 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.1 0.5 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739) tubulin deacetylase activity(GO:0042903)
0.1 0.4 GO:0004103 choline kinase activity(GO:0004103)
0.1 0.4 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.1 3.3 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 2.1 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.3 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0 0.3 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.4 GO:0005131 growth hormone receptor binding(GO:0005131)
0.0 0.4 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.6 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.2 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.4 GO:0005355 glucose transmembrane transporter activity(GO:0005355)
0.0 0.6 GO:0035250 UDP-galactosyltransferase activity(GO:0035250)
0.0 1.7 GO:0008565 protein transporter activity(GO:0008565)
0.0 1.1 GO:0005125 cytokine activity(GO:0005125)
0.0 0.2 GO:0070628 proteasome binding(GO:0070628)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 2.8 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.4 ST_TYPE_I_INTERFERON_PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 0.4 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.7 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.5 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 2.8 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.6 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.4 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.4 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.0 0.4 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.2 REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 0.4 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.6 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.1 REACTOME_TAK1_ACTIVATES_NFKB_BY_PHOSPHORYLATION_AND_ACTIVATION_OF_IKKS_COMPLEX Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.0 0.3 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.3 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway