Motif ID: Nr1h2
Z-value: 1.128

Transcription factors associated with Nr1h2:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Nr1h2 | ENSMUSG00000060601.6 | Nr1h2 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Nr1h2 | mm10_v2_chr7_-_44553901_44553955 | 0.51 | 3.0e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.7 | 6.9 | GO:0044268 | multicellular organismal protein metabolic process(GO:0044268) |
1.6 | 6.4 | GO:0055099 | response to high density lipoprotein particle(GO:0055099) platelet dense granule organization(GO:0060155) |
0.6 | 1.1 | GO:0050703 | interleukin-1 alpha secretion(GO:0050703) |
0.5 | 1.5 | GO:1903279 | regulation of calcium:sodium antiporter activity(GO:1903279) |
0.4 | 2.4 | GO:0045162 | clustering of voltage-gated sodium channels(GO:0045162) |
0.3 | 1.0 | GO:0014891 | striated muscle atrophy(GO:0014891) |
0.3 | 1.8 | GO:0002317 | plasma cell differentiation(GO:0002317) |
0.3 | 1.1 | GO:0016340 | calcium-dependent cell-matrix adhesion(GO:0016340) |
0.3 | 0.8 | GO:0061762 | CAMKK-AMPK signaling cascade(GO:0061762) |
0.2 | 1.4 | GO:0032196 | regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196) |
0.2 | 1.1 | GO:0006689 | ganglioside catabolic process(GO:0006689) oligosaccharide catabolic process(GO:0009313) |
0.2 | 3.7 | GO:0072112 | renal filtration cell differentiation(GO:0061318) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311) |
0.2 | 0.6 | GO:0015920 | lipopolysaccharide transport(GO:0015920) |
0.2 | 1.7 | GO:0006013 | mannose metabolic process(GO:0006013) |
0.2 | 1.0 | GO:0010730 | negative regulation of hydrogen peroxide metabolic process(GO:0010727) negative regulation of hydrogen peroxide biosynthetic process(GO:0010730) |
0.2 | 0.9 | GO:0006777 | Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) |
0.2 | 1.4 | GO:0006265 | DNA topological change(GO:0006265) |
0.2 | 1.2 | GO:0090074 | negative regulation of protein homodimerization activity(GO:0090074) |
0.2 | 1.1 | GO:0030242 | pexophagy(GO:0030242) |
0.1 | 1.7 | GO:0007141 | male meiosis I(GO:0007141) |
0.1 | 1.6 | GO:0051574 | positive regulation of histone H3-K9 methylation(GO:0051574) |
0.1 | 1.4 | GO:2000671 | regulation of motor neuron apoptotic process(GO:2000671) |
0.1 | 2.2 | GO:0021684 | cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707) |
0.1 | 3.1 | GO:0010866 | regulation of triglyceride biosynthetic process(GO:0010866) |
0.1 | 2.2 | GO:0001886 | endothelial cell morphogenesis(GO:0001886) |
0.1 | 0.4 | GO:2000158 | positive regulation of ubiquitin-specific protease activity(GO:2000158) |
0.1 | 0.3 | GO:0006558 | L-phenylalanine metabolic process(GO:0006558) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221) |
0.1 | 0.8 | GO:1901096 | regulation of autophagosome maturation(GO:1901096) |
0.1 | 0.6 | GO:0001922 | B-1 B cell homeostasis(GO:0001922) |
0.1 | 0.8 | GO:0018230 | peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231) |
0.1 | 0.7 | GO:0019368 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
0.1 | 1.3 | GO:0016486 | peptide hormone processing(GO:0016486) |
0.1 | 1.1 | GO:0099612 | protein localization to axon(GO:0099612) |
0.0 | 0.3 | GO:0060050 | positive regulation of protein glycosylation(GO:0060050) |
0.0 | 2.3 | GO:0046676 | negative regulation of insulin secretion(GO:0046676) |
0.0 | 0.5 | GO:0006995 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
0.0 | 0.8 | GO:0080182 | histone H3-K4 trimethylation(GO:0080182) |
0.0 | 0.5 | GO:0006968 | cellular defense response(GO:0006968) |
0.0 | 1.7 | GO:0006891 | intra-Golgi vesicle-mediated transport(GO:0006891) |
0.0 | 0.9 | GO:0030575 | nuclear body organization(GO:0030575) |
0.0 | 0.4 | GO:0060136 | embryonic process involved in female pregnancy(GO:0060136) |
0.0 | 0.7 | GO:0060009 | Sertoli cell development(GO:0060009) |
0.0 | 1.3 | GO:0009988 | cell-cell recognition(GO:0009988) |
0.0 | 0.3 | GO:0050909 | sensory perception of taste(GO:0050909) |
0.0 | 0.7 | GO:0015909 | long-chain fatty acid transport(GO:0015909) |
0.0 | 2.7 | GO:0010508 | positive regulation of autophagy(GO:0010508) |
0.0 | 0.2 | GO:0060623 | regulation of chromosome condensation(GO:0060623) |
0.0 | 0.1 | GO:0001575 | globoside metabolic process(GO:0001575) |
0.0 | 0.5 | GO:0044381 | glucose import in response to insulin stimulus(GO:0044381) |
0.0 | 0.3 | GO:0006883 | cellular sodium ion homeostasis(GO:0006883) |
0.0 | 0.2 | GO:0060700 | regulation of ribonuclease activity(GO:0060700) |
0.0 | 1.2 | GO:0051865 | protein autoubiquitination(GO:0051865) |
0.0 | 1.7 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) |
0.0 | 0.1 | GO:0090238 | positive regulation of arachidonic acid secretion(GO:0090238) |
0.0 | 0.5 | GO:0048147 | negative regulation of fibroblast proliferation(GO:0048147) |
0.0 | 1.9 | GO:0007270 | neuron-neuron synaptic transmission(GO:0007270) |
0.0 | 0.0 | GO:0002002 | regulation of angiotensin levels in blood(GO:0002002) |
0.0 | 0.3 | GO:1901998 | toxin transport(GO:1901998) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 2.4 | GO:0008091 | spectrin(GO:0008091) |
0.4 | 6.4 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
0.3 | 1.7 | GO:0001533 | cornified envelope(GO:0001533) |
0.3 | 1.1 | GO:1990769 | proximal neuron projection(GO:1990769) |
0.2 | 1.5 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
0.2 | 0.7 | GO:0097447 | dendritic tree(GO:0097447) |
0.2 | 1.0 | GO:0031265 | CD95 death-inducing signaling complex(GO:0031265) |
0.1 | 1.1 | GO:1990316 | ATG1/ULK1 kinase complex(GO:1990316) |
0.1 | 0.9 | GO:0042382 | paraspeckles(GO:0042382) |
0.1 | 0.6 | GO:0005964 | phosphorylase kinase complex(GO:0005964) |
0.1 | 1.1 | GO:0043196 | varicosity(GO:0043196) |
0.1 | 1.6 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
0.1 | 0.8 | GO:0002178 | palmitoyltransferase complex(GO:0002178) |
0.0 | 1.7 | GO:0030173 | integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228) |
0.0 | 3.3 | GO:0005776 | autophagosome(GO:0005776) |
0.0 | 5.9 | GO:0001650 | fibrillar center(GO:0001650) |
0.0 | 3.5 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
0.0 | 0.5 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
0.0 | 0.8 | GO:0035097 | histone methyltransferase complex(GO:0035097) |
0.0 | 1.2 | GO:0005814 | centriole(GO:0005814) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.3 | 6.9 | GO:0003989 | acetyl-CoA carboxylase activity(GO:0003989) |
2.1 | 6.4 | GO:0030226 | apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556) |
0.4 | 1.4 | GO:0047844 | deoxycytidine deaminase activity(GO:0047844) |
0.3 | 1.2 | GO:0072345 | NAADP-sensitive calcium-release channel activity(GO:0072345) |
0.3 | 1.4 | GO:0003917 | DNA topoisomerase type I activity(GO:0003917) |
0.3 | 1.4 | GO:0008545 | JUN kinase kinase activity(GO:0008545) |
0.2 | 1.1 | GO:0004563 | beta-N-acetylhexosaminidase activity(GO:0004563) |
0.2 | 0.6 | GO:0071723 | lipopeptide binding(GO:0071723) |
0.2 | 1.1 | GO:0050786 | RAGE receptor binding(GO:0050786) |
0.2 | 1.5 | GO:0008556 | sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556) |
0.2 | 1.7 | GO:0015924 | mannosyl-oligosaccharide mannosidase activity(GO:0015924) |
0.1 | 0.7 | GO:0004095 | carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416) |
0.1 | 0.5 | GO:0055056 | D-glucose transmembrane transporter activity(GO:0055056) |
0.1 | 0.6 | GO:0008269 | JAK pathway signal transduction adaptor activity(GO:0008269) |
0.1 | 1.0 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
0.1 | 2.4 | GO:0030506 | ankyrin binding(GO:0030506) |
0.1 | 0.4 | GO:0035800 | deubiquitinase activator activity(GO:0035800) |
0.1 | 0.3 | GO:0008527 | taste receptor activity(GO:0008527) |
0.1 | 0.5 | GO:0003831 | beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831) |
0.1 | 1.2 | GO:0048273 | mitogen-activated protein kinase p38 binding(GO:0048273) |
0.1 | 0.6 | GO:0004689 | phosphorylase kinase activity(GO:0004689) |
0.1 | 1.3 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
0.1 | 1.7 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
0.1 | 0.7 | GO:0009922 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
0.1 | 0.5 | GO:0008429 | phosphatidylethanolamine binding(GO:0008429) |
0.0 | 1.7 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
0.0 | 0.3 | GO:0043423 | 3-phosphoinositide-dependent protein kinase binding(GO:0043423) |
0.0 | 1.6 | GO:0032452 | histone demethylase activity(GO:0032452) |
0.0 | 1.7 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
0.0 | 0.3 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
0.0 | 3.3 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
0.0 | 0.8 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
0.0 | 0.8 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
0.0 | 2.3 | GO:0019905 | syntaxin binding(GO:0019905) |
0.0 | 1.3 | GO:0051213 | dioxygenase activity(GO:0051213) |
0.0 | 0.9 | GO:0051539 | 4 iron, 4 sulfur cluster binding(GO:0051539) |
0.0 | 0.1 | GO:0015643 | toxic substance binding(GO:0015643) |
0.0 | 0.1 | GO:0047184 | 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184) |
0.0 | 1.5 | GO:0043130 | ubiquitin binding(GO:0043130) |
0.0 | 1.1 | GO:0032947 | protein complex scaffold(GO:0032947) |
0.0 | 3.0 | GO:0008017 | microtubule binding(GO:0008017) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 6.5 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
0.1 | 1.0 | SA_FAS_SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
0.1 | 1.4 | PID_ANTHRAX_PATHWAY | Cellular roles of Anthrax toxin |
0.0 | 2.8 | PID_HES_HEY_PATHWAY | Notch-mediated HES/HEY network |
0.0 | 1.8 | PID_ARF6_TRAFFICKING_PATHWAY | Arf6 trafficking events |
0.0 | 1.8 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
0.0 | 0.7 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
0.0 | 0.9 | PID_INSULIN_PATHWAY | Insulin Pathway |
0.0 | 0.8 | PID_VEGFR1_2_PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
0.0 | 0.6 | PID_IL6_7_PATHWAY | IL6-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 6.4 | REACTOME_HDL_MEDIATED_LIPID_TRANSPORT | Genes involved in HDL-mediated lipid transport |
0.2 | 5.4 | REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS | Genes involved in Fatty Acyl-CoA Biosynthesis |
0.1 | 1.0 | REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
0.1 | 2.4 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
0.1 | 1.4 | REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 | Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
0.1 | 1.5 | REACTOME_BASIGIN_INTERACTIONS | Genes involved in Basigin interactions |
0.1 | 1.7 | REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
0.0 | 0.5 | REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
0.0 | 0.7 | REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
0.0 | 1.1 | REACTOME_GLYCOSPHINGOLIPID_METABOLISM | Genes involved in Glycosphingolipid metabolism |
0.0 | 0.6 | REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
0.0 | 0.6 | REACTOME_REGULATION_OF_KIT_SIGNALING | Genes involved in Regulation of KIT signaling |
0.0 | 0.3 | REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
0.0 | 0.4 | REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
0.0 | 0.5 | REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |