Motif ID: Tbx2

Z-value: 0.536


Transcription factors associated with Tbx2:

Gene SymbolEntrez IDGene Name
Tbx2 ENSMUSG00000000093.6 Tbx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tbx2mm10_v2_chr11_+_85832551_858325510.165.1e-01Click!


Activity profile for motif Tbx2.

activity profile for motif Tbx2


Sorted Z-values histogram for motif Tbx2

Sorted Z-values for motif Tbx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_53850243 0.725 ENSMUST00000048485.5
Sln
sarcolipin
chr5_+_111733924 0.607 ENSMUST00000180627.1
Gm26897
predicted gene, 26897
chr12_+_85473883 0.598 ENSMUST00000021674.6
Fos
FBJ osteosarcoma oncogene
chr4_+_84884418 0.529 ENSMUST00000169371.2
Cntln
centlein, centrosomal protein
chr4_+_94614483 0.494 ENSMUST00000030311.4
ENSMUST00000107104.2
Ift74

intraflagellar transport 74

chr18_-_62741387 0.439 ENSMUST00000097557.3
Spink13
serine peptidase inhibitor, Kazal type 13
chr5_+_32136458 0.430 ENSMUST00000031017.9
Fosl2
fos-like antigen 2
chr11_-_84068766 0.411 ENSMUST00000018792.5
Dusp14
dual specificity phosphatase 14
chr3_-_145649970 0.409 ENSMUST00000029846.3
Cyr61
cysteine rich protein 61
chr4_+_84884276 0.379 ENSMUST00000047023.6
Cntln
centlein, centrosomal protein
chr14_+_80000292 0.377 ENSMUST00000088735.3
Olfm4
olfactomedin 4
chr10_+_106470281 0.368 ENSMUST00000029404.9
ENSMUST00000169303.1
Ppfia2

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2

chr11_+_103101682 0.343 ENSMUST00000107040.3
ENSMUST00000140372.1
ENSMUST00000024492.8
ENSMUST00000134884.1
Acbd4



acyl-Coenzyme A binding domain containing 4



chr16_+_23107413 0.320 ENSMUST00000023599.6
ENSMUST00000168891.1
Eif4a2

eukaryotic translation initiation factor 4A2

chr11_-_84068357 0.308 ENSMUST00000100705.4
Dusp14
dual specificity phosphatase 14
chr12_-_31634592 0.307 ENSMUST00000020979.7
ENSMUST00000177962.1
Bcap29

B cell receptor associated protein 29

chrX_+_159840463 0.300 ENSMUST00000112451.1
ENSMUST00000112453.2
Sh3kbp1

SH3-domain kinase binding protein 1

chr4_+_84884366 0.300 ENSMUST00000102819.3
Cntln
centlein, centrosomal protein
chr2_+_175469985 0.292 ENSMUST00000109042.3
ENSMUST00000109002.2
ENSMUST00000109043.2
ENSMUST00000143490.1
Gm8923



predicted gene 8923



chr19_-_28963863 0.275 ENSMUST00000161813.1
4430402I18Rik
RIKEN cDNA 4430402I18 gene
chr2_+_124089961 0.274 ENSMUST00000103241.1
Sema6d
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr4_-_58499398 0.263 ENSMUST00000107570.1
Lpar1
lysophosphatidic acid receptor 1
chr1_-_105356658 0.253 ENSMUST00000058688.5
ENSMUST00000172299.1
Rnf152

ring finger protein 152

chr17_+_3397189 0.250 ENSMUST00000072156.6
Tiam2
T cell lymphoma invasion and metastasis 2
chr2_-_175703646 0.238 ENSMUST00000109027.2
ENSMUST00000179061.1
ENSMUST00000131041.1
Gm4245


predicted gene 4245


chr2_-_114052804 0.233 ENSMUST00000090269.6
Actc1
actin, alpha, cardiac muscle 1
chrX_+_100730178 0.217 ENSMUST00000113744.1
Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chr2_+_103970115 0.213 ENSMUST00000111143.1
ENSMUST00000138815.1
Lmo2

LIM domain only 2

chr19_+_4003334 0.209 ENSMUST00000025806.3
Doc2g
double C2, gamma
chrX_+_139210031 0.208 ENSMUST00000113043.1
ENSMUST00000169886.1
ENSMUST00000113045.2
Mum1l1


melanoma associated antigen (mutated) 1-like 1


chr10_+_96136603 0.205 ENSMUST00000074615.6
Gm5426
predicted pseudogene 5426
chr6_+_116264186 0.201 ENSMUST00000036503.7
ENSMUST00000112900.3
Zfand4

zinc finger, AN1-type domain 4

chrX_+_100729917 0.196 ENSMUST00000019503.7
Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chr1_+_132191436 0.193 ENSMUST00000112357.2
Lemd1
LEM domain containing 1
chr2_+_52857844 0.192 ENSMUST00000090952.4
ENSMUST00000049483.6
ENSMUST00000050719.6
Fmnl2


formin-like 2


chr2_+_175372436 0.189 ENSMUST00000131676.1
ENSMUST00000109048.2
ENSMUST00000109047.2
Gm4723


predicted gene 4723


chr8_+_45885479 0.184 ENSMUST00000034053.5
Pdlim3
PDZ and LIM domain 3
chr5_-_108132513 0.173 ENSMUST00000119784.1
ENSMUST00000117759.1
Tmed5

transmembrane emp24 protein transport domain containing 5

chr14_+_68083853 0.171 ENSMUST00000022639.7
Nefl
neurofilament, light polypeptide
chr4_+_116221590 0.163 ENSMUST00000147292.1
Pik3r3
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
chr6_-_28261907 0.157 ENSMUST00000115320.1
ENSMUST00000123098.1
ENSMUST00000115321.2
ENSMUST00000155494.1
Zfp800



zinc finger protein 800



chr7_+_79810727 0.154 ENSMUST00000107394.1
Mesp2
mesoderm posterior 2
chr6_+_115134899 0.154 ENSMUST00000009538.5
ENSMUST00000169345.1
Syn2

synapsin II

chr13_+_93308006 0.152 ENSMUST00000079086.6
Homer1
homer homolog 1 (Drosophila)
chr12_-_87775755 0.151 ENSMUST00000164517.2
Gm21319
predicted gene, 21319
chr15_-_10470490 0.151 ENSMUST00000136591.1
Dnajc21
DnaJ (Hsp40) homolog, subfamily C, member 21
chr16_-_43979050 0.150 ENSMUST00000165648.1
ENSMUST00000036321.7
Zdhhc23

zinc finger, DHHC domain containing 23

chr16_+_19028232 0.150 ENSMUST00000074116.4
Gm10088
predicted gene 10088
chr4_+_116221633 0.146 ENSMUST00000030464.7
Pik3r3
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
chr1_-_52500679 0.145 ENSMUST00000069792.7
Nab1
Ngfi-A binding protein 1
chr9_+_48495345 0.144 ENSMUST00000048824.7
Gm5617
predicted gene 5617
chr1_-_172329261 0.141 ENSMUST00000062387.2
Kcnj9
potassium inwardly-rectifying channel, subfamily J, member 9
chr5_-_108132541 0.137 ENSMUST00000119437.1
ENSMUST00000118036.1
Tmed5

transmembrane emp24 protein transport domain containing 5

chr3_+_102734496 0.134 ENSMUST00000029451.5
Tspan2
tetraspanin 2
chr5_+_108065742 0.131 ENSMUST00000081567.4
ENSMUST00000170319.1
ENSMUST00000112626.1
Mtf2


metal response element binding transcription factor 2


chr12_-_41485751 0.129 ENSMUST00000043884.4
Lrrn3
leucine rich repeat protein 3, neuronal
chr3_-_158562199 0.128 ENSMUST00000106044.1
Lrrc7
leucine rich repeat containing 7
chr8_-_122476036 0.125 ENSMUST00000014614.3
Rnf166
ring finger protein 166
chr19_-_46327121 0.120 ENSMUST00000041391.4
ENSMUST00000096029.5
Psd

pleckstrin and Sec7 domain containing

chr3_+_32436376 0.115 ENSMUST00000108242.1
Pik3ca
phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
chr15_+_61987034 0.111 ENSMUST00000159338.1
Myc
myelocytomatosis oncogene
chr5_-_108132577 0.111 ENSMUST00000061203.6
ENSMUST00000002837.4
Tmed5

transmembrane emp24 protein transport domain containing 5

chr3_-_84220853 0.111 ENSMUST00000154152.1
ENSMUST00000107693.2
ENSMUST00000107695.2
Trim2


tripartite motif-containing 2


chr4_+_53440516 0.110 ENSMUST00000107651.2
ENSMUST00000107647.1
Slc44a1

solute carrier family 44, member 1

chr11_+_23306910 0.106 ENSMUST00000137823.1
Usp34
ubiquitin specific peptidase 34
chr4_+_116221689 0.106 ENSMUST00000106490.2
Pik3r3
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
chr5_-_137533170 0.101 ENSMUST00000168746.1
ENSMUST00000170293.1
Gnb2

guanine nucleotide binding protein (G protein), beta 2

chr13_+_80886095 0.095 ENSMUST00000161441.1
Arrdc3
arrestin domain containing 3
chr5_+_108065696 0.092 ENSMUST00000172045.1
Mtf2
metal response element binding transcription factor 2
chr9_-_31464238 0.091 ENSMUST00000048050.7
Tmem45b
transmembrane protein 45b
chr5_-_137533212 0.082 ENSMUST00000111038.1
ENSMUST00000143495.1
Epo
Gnb2
erythropoietin
guanine nucleotide binding protein (G protein), beta 2
chr9_-_85749308 0.079 ENSMUST00000039213.8
Ibtk
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr11_-_69900930 0.077 ENSMUST00000018714.6
ENSMUST00000128046.1
2810408A11Rik

RIKEN cDNA 2810408A11 gene

chr13_-_43304153 0.075 ENSMUST00000055341.5
Gfod1
glucose-fructose oxidoreductase domain containing 1
chr11_+_23306884 0.074 ENSMUST00000180046.1
Usp34
ubiquitin specific peptidase 34
chr1_-_138847579 0.072 ENSMUST00000093486.3
ENSMUST00000046870.6
Lhx9

LIM homeobox protein 9

chr4_+_11191726 0.072 ENSMUST00000029866.9
ENSMUST00000108324.3
Ccne2

cyclin E2

chr7_+_29309429 0.071 ENSMUST00000137848.1
Dpf1
D4, zinc and double PHD fingers family 1
chrX_+_152001845 0.071 ENSMUST00000026289.3
ENSMUST00000112617.3
Hsd17b10

hydroxysteroid (17-beta) dehydrogenase 10

chr11_-_69900949 0.067 ENSMUST00000102580.3
2810408A11Rik
RIKEN cDNA 2810408A11 gene
chr2_-_91182848 0.062 ENSMUST00000111370.2
ENSMUST00000111376.1
ENSMUST00000099723.2
Madd


MAP-kinase activating death domain


chr15_+_79229140 0.062 ENSMUST00000163571.1
Pick1
protein interacting with C kinase 1
chr11_-_87826023 0.061 ENSMUST00000103177.3
Lpo
lactoperoxidase
chr11_+_3330781 0.058 ENSMUST00000136536.1
ENSMUST00000093399.4
Pik3ip1

phosphoinositide-3-kinase interacting protein 1

chr9_-_48495321 0.057 ENSMUST00000170000.2
Rbm7
RNA binding motif protein 7
chr4_+_53440388 0.055 ENSMUST00000102911.3
ENSMUST00000107646.2
Slc44a1

solute carrier family 44, member 1

chr6_+_83054653 0.054 ENSMUST00000092618.6
Aup1
ancient ubiquitous protein 1
chr1_+_131970589 0.049 ENSMUST00000027695.6
Slc45a3
solute carrier family 45, member 3
chr15_-_95528228 0.042 ENSMUST00000075275.2
Nell2
NEL-like 2
chr2_+_164823001 0.040 ENSMUST00000132282.1
Zswim1
zinc finger SWIM-type containing 1
chr1_-_51941261 0.039 ENSMUST00000097103.3
Gm8420
predicted gene 8420
chr4_-_132510493 0.039 ENSMUST00000030724.8
Sesn2
sestrin 2
chr4_-_129573637 0.036 ENSMUST00000102596.1
Lck
lymphocyte protein tyrosine kinase
chr2_-_148045891 0.035 ENSMUST00000109964.1
Foxa2
forkhead box A2
chr9_+_19641224 0.032 ENSMUST00000079042.6
Zfp317
zinc finger protein 317
chr7_+_3645267 0.031 ENSMUST00000038913.9
Cnot3
CCR4-NOT transcription complex, subunit 3
chr4_+_41465134 0.028 ENSMUST00000030154.6
Nudt2
nudix (nucleoside diphosphate linked moiety X)-type motif 2
chr7_+_4792874 0.028 ENSMUST00000032597.5
ENSMUST00000078432.4
Rpl28

ribosomal protein L28

chr19_-_45046614 0.027 ENSMUST00000145391.1
Pdzd7
PDZ domain containing 7
chrX_+_153006461 0.026 ENSMUST00000095755.3
Usp51
ubiquitin specific protease 51
chr19_+_8840519 0.025 ENSMUST00000086058.6
Bscl2
Bernardinelli-Seip congenital lipodystrophy 2 homolog (human)
chr7_+_27607748 0.024 ENSMUST00000136962.1
Akt2
thymoma viral proto-oncogene 2
chr19_-_10304867 0.024 ENSMUST00000039327.4
Dagla
diacylglycerol lipase, alpha
chr13_+_118714678 0.023 ENSMUST00000022246.8
Fgf10
fibroblast growth factor 10
chr15_-_95528702 0.022 ENSMUST00000166170.1
Nell2
NEL-like 2
chr7_-_30563184 0.016 ENSMUST00000043898.6
Psenen
presenilin enhancer 2 homolog (C. elegans)
chr2_-_103797617 0.012 ENSMUST00000028607.6
Caprin1
cell cycle associated protein 1
chr11_+_58104229 0.012 ENSMUST00000108843.1
ENSMUST00000134896.1
Cnot8

CCR4-NOT transcription complex, subunit 8

chr1_+_63273261 0.012 ENSMUST00000114132.1
ENSMUST00000126932.1
Zdbf2

zinc finger, DBF-type containing 2

chr11_-_23895208 0.010 ENSMUST00000102863.2
ENSMUST00000020513.3
Papolg

poly(A) polymerase gamma

chr7_-_137314394 0.007 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
Ebf3



early B cell factor 3



chr2_+_152081529 0.007 ENSMUST00000064061.3
Scrt2
scratch homolog 2, zinc finger protein (Drosophila)
chr1_+_171329015 0.002 ENSMUST00000111300.1
Dedd
death effector domain-containing

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:1901894 regulation of calcium-transporting ATPase activity(GO:1901894)
0.1 0.3 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.1 0.4 GO:0060467 negative regulation of fertilization(GO:0060467)
0.1 0.4 GO:0060591 chondroblast differentiation(GO:0060591)
0.1 1.2 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.1 0.5 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.1 0.3 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.1 0.2 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.0 0.2 GO:0030240 skeletal muscle thin filament assembly(GO:0030240)
0.0 0.2 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.0 0.4 GO:0090527 actin filament reorganization(GO:0090527)
0.0 0.2 GO:0008078 mesodermal cell migration(GO:0008078)
0.0 0.1 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.0 0.1 GO:0014005 microglia differentiation(GO:0014004) microglia development(GO:0014005)
0.0 0.6 GO:0035994 response to muscle stretch(GO:0035994)
0.0 0.2 GO:0015871 choline transport(GO:0015871)
0.0 0.1 GO:0090327 negative regulation of locomotion involved in locomotory behavior(GO:0090327)
0.0 0.1 GO:0044330 canonical Wnt signaling pathway involved in positive regulation of wound healing(GO:0044330) lactic acid secretion(GO:0046722) regulation of metanephric cap mesenchymal cell proliferation(GO:0090095) positive regulation of metanephric cap mesenchymal cell proliferation(GO:0090096)
0.0 0.1 GO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.0 0.4 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.0 GO:0071336 regulation of hair follicle cell proliferation(GO:0071336) positive regulation of hair follicle cell proliferation(GO:0071338)
0.0 0.4 GO:0090161 Golgi ribbon formation(GO:0090161)
0.0 0.7 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.1 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.3 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.0 0.2 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.0 0.0 GO:0015772 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.0 0.1 GO:0035262 gonad morphogenesis(GO:0035262)
0.0 0.0 GO:1902277 negative regulation of pancreatic amylase secretion(GO:1902277)
0.0 0.5 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.0 0.0 GO:0045014 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) detection of glucose(GO:0051594)
0.0 0.2 GO:0048875 chemical homeostasis within a tissue(GO:0048875)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0035976 AP1 complex(GO:0035976)
0.1 0.2 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.0 0.1 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.7 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.4 GO:0042581 specific granule(GO:0042581)
0.0 0.1 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.0 0.4 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.1 GO:0098842 postsynaptic early endosome(GO:0098842)
0.0 0.5 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.4 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 0.1 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.1 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1 0.4 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0 0.7 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.2 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 0.3 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.1 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.1 GO:0005128 erythropoietin receptor binding(GO:0005128)
0.0 0.1 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.1 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.0 0.4 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.0 GO:0008515 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0 0.6 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.1 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0 0.2 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 0.3 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.0 GO:0042610 CD8 receptor binding(GO:0042610)
0.0 0.1 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.4 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 0.5 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.0 0.4 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.6 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.4 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 0.1 REACTOME_REGULATION_OF_SIGNALING_BY_CBL Genes involved in Regulation of signaling by CBL
0.0 0.3 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.2 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle