Motif ID: Ddit3
Z-value: 0.889

Transcription factors associated with Ddit3:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Ddit3 | ENSMUSG00000025408.9 | Ddit3 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Ddit3 | mm10_v2_chr10_+_127290774_127290803 | 0.46 | 5.4e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.7 | 5.9 | GO:0036371 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
0.4 | 2.6 | GO:1902998 | macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
0.4 | 1.2 | GO:0021577 | hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589) |
0.3 | 1.0 | GO:0034334 | adherens junction maintenance(GO:0034334) |
0.3 | 3.1 | GO:0090232 | positive regulation of spindle checkpoint(GO:0090232) |
0.3 | 2.8 | GO:0051901 | positive regulation of mitochondrial depolarization(GO:0051901) |
0.2 | 0.7 | GO:0014826 | vein smooth muscle contraction(GO:0014826) |
0.2 | 1.2 | GO:0018364 | peptidyl-glutamine methylation(GO:0018364) |
0.2 | 1.4 | GO:0019695 | choline metabolic process(GO:0019695) |
0.2 | 2.7 | GO:1903818 | positive regulation of voltage-gated potassium channel activity(GO:1903818) |
0.2 | 1.8 | GO:0033184 | positive regulation of histone ubiquitination(GO:0033184) |
0.2 | 1.7 | GO:0018095 | protein polyglutamylation(GO:0018095) |
0.2 | 1.3 | GO:0044838 | cell quiescence(GO:0044838) |
0.2 | 0.5 | GO:0097360 | chorionic trophoblast cell proliferation(GO:0097360) regulation of chorionic trophoblast cell proliferation(GO:1901382) |
0.2 | 0.5 | GO:2000620 | positive regulation of histone H4-K16 acetylation(GO:2000620) |
0.2 | 0.7 | GO:0099527 | postsynapse to nucleus signaling pathway(GO:0099527) |
0.2 | 0.6 | GO:0006751 | glutathione catabolic process(GO:0006751) |
0.1 | 0.4 | GO:0051715 | cytolysis in other organism(GO:0051715) |
0.1 | 0.4 | GO:0086042 | cardiac muscle cell-cardiac muscle cell adhesion(GO:0086042) |
0.1 | 0.5 | GO:0010961 | cellular magnesium ion homeostasis(GO:0010961) calcium-dependent cell-matrix adhesion(GO:0016340) |
0.1 | 0.4 | GO:0051892 | negative regulation of cardioblast differentiation(GO:0051892) |
0.1 | 0.5 | GO:0070086 | ubiquitin-dependent endocytosis(GO:0070086) |
0.1 | 0.4 | GO:0070649 | meiotic chromosome movement towards spindle pole(GO:0016344) formin-nucleated actin cable assembly(GO:0070649) |
0.1 | 0.4 | GO:0033540 | fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540) |
0.1 | 0.7 | GO:0006561 | proline biosynthetic process(GO:0006561) |
0.1 | 0.6 | GO:1903056 | positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056) |
0.1 | 0.4 | GO:0016240 | autophagosome docking(GO:0016240) |
0.1 | 1.5 | GO:0050901 | leukocyte tethering or rolling(GO:0050901) |
0.1 | 0.5 | GO:0072318 | clathrin coat disassembly(GO:0072318) |
0.1 | 1.6 | GO:0045475 | locomotor rhythm(GO:0045475) |
0.1 | 0.5 | GO:0030242 | pexophagy(GO:0030242) |
0.1 | 0.2 | GO:0038027 | apolipoprotein A-I-mediated signaling pathway(GO:0038027) |
0.1 | 0.3 | GO:0036089 | cleavage furrow formation(GO:0036089) |
0.1 | 0.9 | GO:1990403 | embryonic brain development(GO:1990403) |
0.1 | 0.5 | GO:0071816 | tail-anchored membrane protein insertion into ER membrane(GO:0071816) |
0.1 | 1.5 | GO:0031571 | mitotic G1 DNA damage checkpoint(GO:0031571) |
0.1 | 0.4 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
0.1 | 0.1 | GO:0071680 | response to indole-3-methanol(GO:0071680) cellular response to indole-3-methanol(GO:0071681) |
0.1 | 0.2 | GO:0042138 | meiotic DNA double-strand break formation(GO:0042138) |
0.0 | 1.1 | GO:0008090 | retrograde axonal transport(GO:0008090) |
0.0 | 1.2 | GO:0035025 | positive regulation of Rho protein signal transduction(GO:0035025) |
0.0 | 0.2 | GO:0061086 | negative regulation of histone H3-K27 methylation(GO:0061086) |
0.0 | 0.4 | GO:0061635 | regulation of protein complex stability(GO:0061635) |
0.0 | 0.5 | GO:0000244 | spliceosomal tri-snRNP complex assembly(GO:0000244) |
0.0 | 0.3 | GO:0031125 | rRNA 3'-end processing(GO:0031125) |
0.0 | 2.8 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
0.0 | 0.5 | GO:0015809 | arginine transport(GO:0015809) |
0.0 | 0.1 | GO:0010845 | positive regulation of reciprocal meiotic recombination(GO:0010845) |
0.0 | 0.2 | GO:0048842 | positive regulation of axon extension involved in axon guidance(GO:0048842) |
0.0 | 0.2 | GO:2000483 | negative regulation of interleukin-8 secretion(GO:2000483) |
0.0 | 0.1 | GO:1990928 | response to amino acid starvation(GO:1990928) |
0.0 | 0.3 | GO:0035881 | amacrine cell differentiation(GO:0035881) |
0.0 | 0.1 | GO:0010747 | positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747) |
0.0 | 0.7 | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184) |
0.0 | 0.3 | GO:0051457 | maintenance of protein location in nucleus(GO:0051457) |
0.0 | 0.7 | GO:0006904 | vesicle docking involved in exocytosis(GO:0006904) |
0.0 | 0.4 | GO:0000305 | response to oxygen radical(GO:0000305) |
0.0 | 0.2 | GO:0099517 | anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517) |
0.0 | 0.1 | GO:2000973 | regulation of pro-B cell differentiation(GO:2000973) |
0.0 | 0.1 | GO:0032464 | positive regulation of protein homooligomerization(GO:0032464) |
0.0 | 1.6 | GO:0007416 | synapse assembly(GO:0007416) |
0.0 | 1.3 | GO:0051592 | response to calcium ion(GO:0051592) |
0.0 | 1.2 | GO:0043149 | contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 1.1 | GO:0031673 | H zone(GO:0031673) |
0.2 | 2.6 | GO:0097418 | neurofibrillary tangle(GO:0097418) |
0.2 | 5.9 | GO:0031430 | M band(GO:0031430) |
0.2 | 2.8 | GO:0043203 | axon hillock(GO:0043203) |
0.2 | 1.2 | GO:0031428 | box C/D snoRNP complex(GO:0031428) |
0.2 | 2.5 | GO:0043083 | synaptic cleft(GO:0043083) |
0.2 | 1.5 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
0.1 | 0.4 | GO:0097629 | extrinsic component of omegasome membrane(GO:0097629) |
0.1 | 4.6 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
0.1 | 1.5 | GO:1990635 | proximal dendrite(GO:1990635) |
0.1 | 3.1 | GO:0055038 | recycling endosome membrane(GO:0055038) |
0.1 | 1.5 | GO:0016514 | SWI/SNF complex(GO:0016514) |
0.1 | 0.5 | GO:0043196 | varicosity(GO:0043196) |
0.0 | 0.3 | GO:0071204 | histone pre-mRNA 3'end processing complex(GO:0071204) |
0.0 | 0.4 | GO:0030008 | TRAPP complex(GO:0030008) |
0.0 | 0.5 | GO:0005682 | U5 snRNP(GO:0005682) |
0.0 | 0.9 | GO:0035869 | ciliary transition zone(GO:0035869) |
0.0 | 1.0 | GO:0005912 | adherens junction(GO:0005912) |
0.0 | 0.4 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
0.0 | 0.7 | GO:0035145 | exon-exon junction complex(GO:0035145) |
0.0 | 0.4 | GO:0030914 | STAGA complex(GO:0030914) |
0.0 | 0.1 | GO:0005850 | eukaryotic translation initiation factor 2 complex(GO:0005850) |
0.0 | 1.4 | GO:0005604 | basement membrane(GO:0005604) |
0.0 | 0.2 | GO:1904115 | axon cytoplasm(GO:1904115) |
0.0 | 0.5 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
0.0 | 0.2 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
0.0 | 1.5 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
0.0 | 0.2 | GO:0001891 | phagocytic cup(GO:0001891) |
0.0 | 0.1 | GO:0043219 | lateral loop(GO:0043219) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 1.3 | GO:0098770 | FBXO family protein binding(GO:0098770) |
0.4 | 1.7 | GO:0070740 | tubulin-glutamic acid ligase activity(GO:0070740) |
0.4 | 1.4 | GO:0004104 | cholinesterase activity(GO:0004104) choline binding(GO:0033265) |
0.3 | 1.5 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
0.3 | 1.8 | GO:0045322 | unmethylated CpG binding(GO:0045322) |
0.2 | 0.7 | GO:0004962 | endothelin receptor activity(GO:0004962) |
0.2 | 0.7 | GO:0004735 | pyrroline-5-carboxylate reductase activity(GO:0004735) |
0.2 | 0.5 | GO:0000386 | second spliceosomal transesterification activity(GO:0000386) |
0.1 | 2.7 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
0.1 | 2.8 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
0.1 | 0.6 | GO:0004719 | protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719) |
0.1 | 7.4 | GO:0030507 | spectrin binding(GO:0030507) |
0.1 | 0.6 | GO:0003839 | gamma-glutamylcyclotransferase activity(GO:0003839) |
0.1 | 0.3 | GO:0071207 | histone pre-mRNA stem-loop binding(GO:0071207) |
0.1 | 0.4 | GO:0042834 | peptidoglycan binding(GO:0042834) |
0.1 | 2.6 | GO:0051787 | misfolded protein binding(GO:0051787) |
0.1 | 0.4 | GO:0086080 | protein binding involved in heterotypic cell-cell adhesion(GO:0086080) |
0.1 | 0.6 | GO:0001849 | complement component C1q binding(GO:0001849) |
0.1 | 0.2 | GO:0030226 | apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556) |
0.1 | 1.2 | GO:0008649 | rRNA methyltransferase activity(GO:0008649) |
0.1 | 3.1 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
0.1 | 1.2 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
0.1 | 0.4 | GO:0016401 | palmitoyl-CoA oxidase activity(GO:0016401) |
0.1 | 0.2 | GO:0035373 | chondroitin sulfate proteoglycan binding(GO:0035373) |
0.1 | 0.4 | GO:0004791 | thioredoxin-disulfide reductase activity(GO:0004791) |
0.1 | 0.5 | GO:0015181 | arginine transmembrane transporter activity(GO:0015181) |
0.1 | 1.1 | GO:0005003 | ephrin receptor activity(GO:0005003) |
0.1 | 1.5 | GO:0070064 | proline-rich region binding(GO:0070064) |
0.0 | 1.2 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
0.0 | 1.0 | GO:0003785 | actin monomer binding(GO:0003785) |
0.0 | 1.2 | GO:0042169 | SH2 domain binding(GO:0042169) |
0.0 | 0.2 | GO:0000990 | transcription factor activity, core RNA polymerase binding(GO:0000990) |
0.0 | 0.5 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
0.0 | 0.7 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
0.0 | 0.9 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
0.0 | 0.8 | GO:0051018 | protein kinase A binding(GO:0051018) |
0.0 | 0.6 | GO:0070412 | R-SMAD binding(GO:0070412) |
0.0 | 0.5 | GO:0000062 | fatty-acyl-CoA binding(GO:0000062) |
0.0 | 0.2 | GO:0015929 | hexosaminidase activity(GO:0015929) |
0.0 | 5.8 | GO:0005509 | calcium ion binding(GO:0005509) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 5.7 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
0.0 | 1.1 | PID_EPHA_FWDPATHWAY | EPHA forward signaling |
0.0 | 1.3 | PID_IL2_STAT5_PATHWAY | IL2 signaling events mediated by STAT5 |
0.0 | 1.2 | PID_LIS1_PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
0.0 | 1.4 | PID_ATF2_PATHWAY | ATF-2 transcription factor network |
0.0 | 0.9 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
0.0 | 0.5 | PID_WNT_CANONICAL_PATHWAY | Canonical Wnt signaling pathway |
0.0 | 0.3 | PID_MYC_PATHWAY | C-MYC pathway |
0.0 | 1.1 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
0.0 | 0.7 | PID_PI3KCI_AKT_PATHWAY | Class I PI3K signaling events mediated by Akt |
0.0 | 0.7 | PID_FAK_PATHWAY | Signaling events mediated by focal adhesion kinase |
0.0 | 1.0 | PID_HEDGEHOG_GLI_PATHWAY | Hedgehog signaling events mediated by Gli proteins |
0.0 | 0.5 | PID_ENDOTHELIN_PATHWAY | Endothelins |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 4.2 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
0.1 | 1.4 | REACTOME_SYNTHESIS_OF_PC | Genes involved in Synthesis of PC |
0.0 | 0.7 | REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
0.0 | 1.2 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
0.0 | 2.6 | REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ | Genes involved in Response to elevated platelet cytosolic Ca2+ |
0.0 | 1.3 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
0.0 | 0.4 | REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
0.0 | 0.5 | REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
0.0 | 0.4 | REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
0.0 | 0.5 | REACTOME_LYSOSOME_VESICLE_BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
0.0 | 0.5 | REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
0.0 | 0.6 | REACTOME_MRNA_3_END_PROCESSING | Genes involved in mRNA 3'-end processing |
0.0 | 0.2 | REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
0.0 | 0.5 | REACTOME_MRNA_SPLICING_MINOR_PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |