Motif ID: Vsx1_Uncx_Prrx2_Shox2_Noto

Z-value: 0.980


Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Uncxmm10_v2_chr5_+_139543889_1395439040.815.5e-05Click!
Prrx2mm10_v2_chr2_+_30834972_308349720.484.6e-02Click!
Shox2mm10_v2_chr3_-_66981279_669813180.126.2e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Vsx1_Uncx_Prrx2_Shox2_Noto

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_-_48665098 12.330 ENSMUST00000118578.1
Otx2
orthodenticle homolog 2 (Drosophila)
chr5_+_139543889 12.155 ENSMUST00000174792.1
ENSMUST00000031523.8
Uncx

UNC homeobox

chr2_+_20737306 9.792 ENSMUST00000114606.1
ENSMUST00000114608.1
Etl4

enhancer trap locus 4

chr6_-_147264124 7.633 ENSMUST00000052296.6
Pthlh
parathyroid hormone-like peptide
chr2_-_168767136 7.078 ENSMUST00000029061.5
ENSMUST00000103074.1
Sall4

sal-like 4 (Drosophila)

chr14_-_118052235 7.054 ENSMUST00000022725.2
Dct
dopachrome tautomerase
chr2_-_168767029 6.724 ENSMUST00000075044.3
Sall4
sal-like 4 (Drosophila)
chr8_-_61902669 6.583 ENSMUST00000121785.1
ENSMUST00000034057.7
Palld

palladin, cytoskeletal associated protein

chr17_+_34592248 6.342 ENSMUST00000038149.6
Pbx2
pre B cell leukemia homeobox 2
chr3_+_125404292 6.319 ENSMUST00000144344.1
Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr3_+_125404072 6.190 ENSMUST00000173932.1
Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr3_+_55782500 5.642 ENSMUST00000075422.4
Mab21l1
mab-21-like 1 (C. elegans)
chr3_+_159839729 4.769 ENSMUST00000068952.5
Wls
wntless homolog (Drosophila)
chr7_-_49636847 4.768 ENSMUST00000032717.6
Dbx1
developing brain homeobox 1
chr13_-_53473074 4.672 ENSMUST00000021922.8
Msx2
msh homeobox 2
chr4_-_97778042 4.646 ENSMUST00000146447.1
E130114P18Rik
RIKEN cDNA E130114P18 gene
chrX_-_60893430 4.224 ENSMUST00000135107.2
Sox3
SRY-box containing gene 3
chr13_-_102905740 4.034 ENSMUST00000167462.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr13_-_102906046 3.969 ENSMUST00000171791.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr4_-_35845204 3.677 ENSMUST00000164772.1
ENSMUST00000065173.2
Lingo2

leucine rich repeat and Ig domain containing 2

chrM_+_7005 3.628 ENSMUST00000082405.1
mt-Co2
mitochondrially encoded cytochrome c oxidase II
chr10_-_45470201 3.545 ENSMUST00000079390.6
Lin28b
lin-28 homolog B (C. elegans)
chr3_-_79841729 3.336 ENSMUST00000168038.1
Tmem144
transmembrane protein 144
chr9_+_119063429 3.122 ENSMUST00000141185.1
ENSMUST00000126251.1
ENSMUST00000136561.1
Vill


villin-like


chr19_+_59458372 2.987 ENSMUST00000062216.3
Emx2
empty spiracles homeobox 2
chr16_-_26989974 2.978 ENSMUST00000089832.4
Gmnc
geminin coiled-coil domain containing
chr3_-_88410295 2.948 ENSMUST00000056370.7
Pmf1
polyamine-modulated factor 1
chr3_-_154328634 2.830 ENSMUST00000167744.1
Lhx8
LIM homeobox protein 8
chr2_+_25372315 2.827 ENSMUST00000028329.6
ENSMUST00000114293.2
ENSMUST00000100323.2
Sapcd2


suppressor APC domain containing 2


chr4_-_58499398 2.799 ENSMUST00000107570.1
Lpar1
lysophosphatidic acid receptor 1
chr9_+_118478344 2.769 ENSMUST00000035020.8
Eomes
eomesodermin homolog (Xenopus laevis)
chr5_+_115235836 2.736 ENSMUST00000081497.6
Pop5
processing of precursor 5, ribonuclease P/MRP family (S. cerevisiae)
chr17_+_17402672 2.692 ENSMUST00000115576.2
Lix1
limb expression 1 homolog (chicken)
chr4_-_4138432 2.492 ENSMUST00000070375.7
Penk
preproenkephalin
chr7_-_116198487 2.349 ENSMUST00000181981.1
Plekha7
pleckstrin homology domain containing, family A member 7
chr3_+_134236483 2.285 ENSMUST00000181904.1
ENSMUST00000053048.9
Cxxc4

CXXC finger 4

chr7_+_144838590 2.282 ENSMUST00000105898.1
Fgf3
fibroblast growth factor 3
chrM_+_2743 2.149 ENSMUST00000082392.1
mt-Nd1
mitochondrially encoded NADH dehydrogenase 1
chr6_-_124779686 2.117 ENSMUST00000147669.1
ENSMUST00000128697.1
ENSMUST00000032218.3
ENSMUST00000112475.2
Lrrc23



leucine rich repeat containing 23



chr11_+_102604370 2.069 ENSMUST00000057893.5
Fzd2
frizzled homolog 2 (Drosophila)
chr13_-_78196373 2.039 ENSMUST00000125176.2
Nr2f1
nuclear receptor subfamily 2, group F, member 1
chr1_+_109983737 1.985 ENSMUST00000172005.1
Cdh7
cadherin 7, type 2
chr13_+_23575753 1.943 ENSMUST00000105105.1
Hist1h3d
histone cluster 1, H3d
chr4_-_110292719 1.923 ENSMUST00000106601.1
Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr8_+_45658666 1.899 ENSMUST00000134675.1
ENSMUST00000139869.1
ENSMUST00000126067.1
Sorbs2


sorbin and SH3 domain containing 2


chr8_+_45658731 1.889 ENSMUST00000143820.1
ENSMUST00000132139.1
Sorbs2

sorbin and SH3 domain containing 2

chr2_+_61804453 1.880 ENSMUST00000048934.8
Tbr1
T-box brain gene 1
chr9_-_71163224 1.741 ENSMUST00000074465.2
Aqp9
aquaporin 9
chr9_+_118478182 1.741 ENSMUST00000111763.1
Eomes
eomesodermin homolog (Xenopus laevis)
chr5_+_15516489 1.715 ENSMUST00000178227.1
Gm21847
predicted gene, 21847
chr2_-_28916412 1.669 ENSMUST00000050776.2
ENSMUST00000113849.1
Barhl1

BarH-like 1 (Drosophila)

chr1_-_172027269 1.641 ENSMUST00000027837.6
ENSMUST00000111264.1
Vangl2

vang-like 2 (van gogh, Drosophila)

chr17_-_35697971 1.627 ENSMUST00000146472.1
Ddr1
discoidin domain receptor family, member 1
chr7_-_37773555 1.598 ENSMUST00000176534.1
Zfp536
zinc finger protein 536
chr13_+_89540636 1.574 ENSMUST00000022108.7
Hapln1
hyaluronan and proteoglycan link protein 1
chr2_-_72986716 1.571 ENSMUST00000112062.1
Gm11084
predicted gene 11084
chr2_+_9882622 1.553 ENSMUST00000114919.1
4930412O13Rik
RIKEN cDNA 4930412O13 gene
chr3_-_116253467 1.458 ENSMUST00000090473.5
Gpr88
G-protein coupled receptor 88
chr2_-_28916668 1.384 ENSMUST00000113847.1
Barhl1
BarH-like 1 (Drosophila)
chr14_-_46390501 1.370 ENSMUST00000100676.2
Bmp4
bone morphogenetic protein 4
chr13_-_114458720 1.352 ENSMUST00000022287.5
Fst
follistatin
chr1_-_78968079 1.344 ENSMUST00000049117.5
Gm5830
predicted pseudogene 5830
chr19_+_24875679 1.341 ENSMUST00000073080.5
Gm10053
predicted gene 10053
chr11_+_60537978 1.299 ENSMUST00000044250.3
Alkbh5
alkB, alkylation repair homolog 5 (E. coli)
chr1_+_110099295 1.280 ENSMUST00000134301.1
Cdh7
cadherin 7, type 2
chr8_-_84662841 1.274 ENSMUST00000060427.4
Ier2
immediate early response 2
chr6_+_29859374 1.272 ENSMUST00000115238.3
Ahcyl2
S-adenosylhomocysteine hydrolase-like 2
chr3_+_122044428 1.254 ENSMUST00000013995.8
Abca4
ATP-binding cassette, sub-family A (ABC1), member 4
chr9_+_106368594 1.206 ENSMUST00000172306.2
Dusp7
dual specificity phosphatase 7
chr7_-_66427469 1.193 ENSMUST00000015278.7
Aldh1a3
aldehyde dehydrogenase family 1, subfamily A3
chr3_-_17786834 1.189 ENSMUST00000099198.2
Gm10742
predicted gene 10742
chr10_+_102158858 1.185 ENSMUST00000138522.1
ENSMUST00000163753.1
ENSMUST00000138016.1
Mgat4c


mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)


chr6_+_125552948 1.180 ENSMUST00000112254.1
ENSMUST00000112253.1
ENSMUST00000001995.7
Vwf


Von Willebrand factor homolog


chr2_+_38341068 1.180 ENSMUST00000133661.1
Lhx2
LIM homeobox protein 2
chr1_-_72284248 1.172 ENSMUST00000097698.4
ENSMUST00000027381.6
Pecr

peroxisomal trans-2-enoyl-CoA reductase

chr14_-_48667508 1.156 ENSMUST00000144465.1
ENSMUST00000133479.1
ENSMUST00000119070.1
ENSMUST00000152018.1
Otx2



orthodenticle homolog 2 (Drosophila)



chr3_+_121291725 1.156 ENSMUST00000039442.7
Alg14
asparagine-linked glycosylation 14
chr7_+_114745685 1.116 ENSMUST00000136645.1
ENSMUST00000169913.1
Insc

inscuteable homolog (Drosophila)

chr11_-_50292302 1.108 ENSMUST00000059458.4
Maml1
mastermind like 1 (Drosophila)
chr14_+_79515618 1.099 ENSMUST00000110835.1
Elf1
E74-like factor 1
chr11_+_52098681 1.095 ENSMUST00000020608.2
Ppp2ca
protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
chr7_-_45830776 1.069 ENSMUST00000107723.2
ENSMUST00000131384.1
Grwd1

glutamate-rich WD repeat containing 1

chr7_+_28881656 1.068 ENSMUST00000066880.4
Capn12
calpain 12
chr1_+_10993452 1.056 ENSMUST00000027056.5
Prex2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr7_-_5014645 1.046 ENSMUST00000165320.1
Fiz1
Flt3 interacting zinc finger protein 1
chr6_+_7555053 1.004 ENSMUST00000090679.2
ENSMUST00000184986.1
Tac1

tachykinin 1

chr5_+_138187485 1.001 ENSMUST00000110934.2
Cnpy4
canopy 4 homolog (zebrafish)
chr9_+_72806874 0.993 ENSMUST00000055535.8
Prtg
protogenin homolog (Gallus gallus)
chr2_-_30093642 0.977 ENSMUST00000102865.4
Zdhhc12
zinc finger, DHHC domain containing 12
chr2_-_18048784 0.972 ENSMUST00000142856.1
Skida1
SKI/DACH domain containing 1
chr12_-_57546121 0.963 ENSMUST00000044380.6
Foxa1
forkhead box A1
chr3_-_100489324 0.960 ENSMUST00000061455.8
Fam46c
family with sequence similarity 46, member C
chr14_-_12345847 0.958 ENSMUST00000022262.4
Fezf2
Fez family zinc finger 2
chr7_-_115824699 0.954 ENSMUST00000169129.1
Sox6
SRY-box containing gene 6
chr5_-_87482258 0.953 ENSMUST00000079811.6
ENSMUST00000144144.1
Ugt2a1

UDP glucuronosyltransferase 2 family, polypeptide A1

chr10_+_26772477 0.925 ENSMUST00000039557.7
Arhgap18
Rho GTPase activating protein 18
chr1_+_153665666 0.910 ENSMUST00000111814.1
ENSMUST00000111810.1
Rgs8

regulator of G-protein signaling 8

chr14_-_46390576 0.907 ENSMUST00000074077.5
Bmp4
bone morphogenetic protein 4
chr2_-_33718789 0.898 ENSMUST00000130532.1
9430024E24Rik
RIKEN cDNA 9430024E24 gene
chr1_+_153665274 0.896 ENSMUST00000152114.1
ENSMUST00000111812.1
Rgs8

regulator of G-protein signaling 8

chr10_+_128337761 0.895 ENSMUST00000005826.7
Cs
citrate synthase
chr2_+_132847719 0.892 ENSMUST00000124836.1
ENSMUST00000154160.1
Crls1

cardiolipin synthase 1

chr7_+_49910112 0.886 ENSMUST00000056442.5
Slc6a5
solute carrier family 6 (neurotransmitter transporter, glycine), member 5
chr6_+_79818031 0.884 ENSMUST00000179797.1
Gm20594
predicted gene, 20594
chr3_-_157925056 0.883 ENSMUST00000118539.1
Cth
cystathionase (cystathionine gamma-lyase)
chrM_+_9452 0.880 ENSMUST00000082411.1
mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chr11_+_94327984 0.879 ENSMUST00000107818.2
ENSMUST00000051221.6
Ankrd40

ankyrin repeat domain 40

chr11_-_31671863 0.870 ENSMUST00000058060.7
Bod1
biorientation of chromosomes in cell division 1
chr2_-_30093607 0.860 ENSMUST00000081838.6
Zdhhc12
zinc finger, DHHC domain containing 12
chr2_+_109917639 0.856 ENSMUST00000046548.7
ENSMUST00000111037.2
Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr3_+_67892189 0.852 ENSMUST00000063263.3
Iqcj
IQ motif containing J
chr12_+_55598917 0.844 ENSMUST00000051857.3
Insm2
insulinoma-associated 2
chr12_+_38783503 0.838 ENSMUST00000159334.1
Etv1
ets variant gene 1
chr18_+_34758890 0.818 ENSMUST00000049281.5
Fam53c
family with sequence similarity 53, member C
chr17_-_48432723 0.815 ENSMUST00000046549.3
Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr10_+_128747850 0.813 ENSMUST00000163377.2
Wibg
within bgcn homolog (Drosophila)
chr15_-_9140374 0.807 ENSMUST00000096482.3
ENSMUST00000110585.2
Skp2

S-phase kinase-associated protein 2 (p45)

chr6_+_29859662 0.806 ENSMUST00000128927.2
Ahcyl2
S-adenosylhomocysteine hydrolase-like 2
chr3_+_32515295 0.801 ENSMUST00000029203.7
Zfp639
zinc finger protein 639
chr5_-_77115145 0.788 ENSMUST00000081964.5
Hopx
HOP homeobox
chr14_+_73237891 0.788 ENSMUST00000044405.6
Lpar6
lysophosphatidic acid receptor 6
chr8_-_45382198 0.771 ENSMUST00000093526.6
Fam149a
family with sequence similarity 149, member A
chr11_+_98798653 0.743 ENSMUST00000037930.6
Msl1
male-specific lethal 1 homolog (Drosophila)
chr10_+_37139558 0.740 ENSMUST00000062667.3
5930403N24Rik
RIKEN cDNA 5930403N24 gene
chr10_+_88091070 0.739 ENSMUST00000048621.7
Pmch
pro-melanin-concentrating hormone
chr5_-_138187177 0.737 ENSMUST00000110937.1
ENSMUST00000139276.1
ENSMUST00000048698.7
ENSMUST00000123415.1
Taf6



TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor



chr7_-_37772868 0.720 ENSMUST00000176205.1
Zfp536
zinc finger protein 536
chr18_+_4993795 0.719 ENSMUST00000153016.1
Svil
supervillin
chr19_-_15924560 0.716 ENSMUST00000162053.1
Psat1
phosphoserine aminotransferase 1
chr7_+_125829653 0.682 ENSMUST00000124223.1
D430042O09Rik
RIKEN cDNA D430042O09 gene
chr1_+_153665627 0.680 ENSMUST00000147482.1
Rgs8
regulator of G-protein signaling 8
chr1_-_172027251 0.670 ENSMUST00000138714.1
Vangl2
vang-like 2 (van gogh, Drosophila)
chr1_+_87183310 0.665 ENSMUST00000044533.8
Prss56
protease, serine 56
chr1_+_153665587 0.662 ENSMUST00000147700.1
Rgs8
regulator of G-protein signaling 8
chr6_+_29859686 0.654 ENSMUST00000134438.1
Ahcyl2
S-adenosylhomocysteine hydrolase-like 2
chr18_-_66022580 0.643 ENSMUST00000143990.1
Lman1
lectin, mannose-binding, 1
chr4_+_154960915 0.618 ENSMUST00000049621.6
Hes5
hairy and enhancer of split 5 (Drosophila)
chr8_+_45627709 0.614 ENSMUST00000134321.1
ENSMUST00000135336.1
Sorbs2

sorbin and SH3 domain containing 2

chr2_+_3114220 0.613 ENSMUST00000072955.5
Fam171a1
family with sequence similarity 171, member A1
chr15_-_34495180 0.596 ENSMUST00000022946.5
Hrsp12
heat-responsive protein 12
chr9_+_35423582 0.588 ENSMUST00000154652.1
Cdon
cell adhesion molecule-related/down-regulated by oncogenes
chr8_+_121116163 0.583 ENSMUST00000054691.6
Foxc2
forkhead box C2
chr11_+_114851507 0.580 ENSMUST00000177952.1
Gprc5c
G protein-coupled receptor, family C, group 5, member C
chrM_+_8600 0.576 ENSMUST00000082409.1
mt-Co3
mitochondrially encoded cytochrome c oxidase III
chr1_-_190170671 0.574 ENSMUST00000175916.1
Prox1
prospero-related homeobox 1
chr2_+_71389239 0.573 ENSMUST00000028408.2
Hat1
histone aminotransferase 1
chr9_+_45138437 0.562 ENSMUST00000060125.5
Scn4b
sodium channel, type IV, beta
chr4_-_45532470 0.553 ENSMUST00000147448.1
Shb
src homology 2 domain-containing transforming protein B
chrX_-_102157065 0.551 ENSMUST00000056904.2
Ercc6l
excision repair cross-complementing rodent repair deficiency complementation group 6 like
chr3_-_86548268 0.547 ENSMUST00000077524.3
Mab21l2
mab-21-like 2 (C. elegans)
chr8_+_23411490 0.544 ENSMUST00000033952.7
Sfrp1
secreted frizzled-related protein 1
chr3_+_133338936 0.543 ENSMUST00000150386.1
ENSMUST00000125858.1
Ppa2

pyrophosphatase (inorganic) 2

chr6_+_134929118 0.543 ENSMUST00000185152.1
ENSMUST00000184504.1
RP23-45G16.5

RP23-45G16.5

chr2_+_181767040 0.543 ENSMUST00000108756.1
Myt1
myelin transcription factor 1
chrX_+_169685191 0.541 ENSMUST00000112104.1
ENSMUST00000112107.1
Mid1

midline 1

chr2_+_80638798 0.540 ENSMUST00000028382.6
ENSMUST00000124377.1
Nup35

nucleoporin 35

chr11_-_31671727 0.528 ENSMUST00000109415.1
Bod1
biorientation of chromosomes in cell division 1
chr17_+_12119274 0.524 ENSMUST00000024594.2
Agpat4
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
chr2_+_181767283 0.516 ENSMUST00000108757.2
Myt1
myelin transcription factor 1
chr2_+_52038005 0.503 ENSMUST00000065927.5
Tnfaip6
tumor necrosis factor alpha induced protein 6
chrX_-_134111852 0.496 ENSMUST00000033610.6
Nox1
NADPH oxidase 1
chr2_+_152754156 0.496 ENSMUST00000010020.5
Cox4i2
cytochrome c oxidase subunit IV isoform 2
chr10_-_80421847 0.494 ENSMUST00000156244.1
Tcf3
transcription factor 3
chr4_-_42168603 0.486 ENSMUST00000098121.3
Gm13305
predicted gene 13305
chrX_+_159303266 0.479 ENSMUST00000112491.1
Rps6ka3
ribosomal protein S6 kinase polypeptide 3
chr3_-_141982224 0.478 ENSMUST00000029948.8
Bmpr1b
bone morphogenetic protein receptor, type 1B
chr5_+_34999046 0.478 ENSMUST00000114281.1
Rgs12
regulator of G-protein signaling 12
chr2_-_58052832 0.477 ENSMUST00000090940.5
Ermn
ermin, ERM-like protein
chr2_-_174346712 0.474 ENSMUST00000168292.1
Gm20721
predicted gene, 20721
chr4_-_132510493 0.463 ENSMUST00000030724.8
Sesn2
sestrin 2
chr4_+_5724304 0.462 ENSMUST00000108380.1
Fam110b
family with sequence similarity 110, member B
chr6_-_148946146 0.459 ENSMUST00000132696.1
Fam60a
family with sequence similarity 60, member A
chr17_-_24073479 0.458 ENSMUST00000017090.5
Kctd5
potassium channel tetramerisation domain containing 5
chr9_+_65890237 0.454 ENSMUST00000045802.6
2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr9_+_96258697 0.454 ENSMUST00000179416.1
Tfdp2
transcription factor Dp 2
chr1_+_74284930 0.450 ENSMUST00000113805.1
ENSMUST00000027370.6
ENSMUST00000087226.4
Pnkd


paroxysmal nonkinesiogenic dyskinesia


chr7_+_101896340 0.449 ENSMUST00000035395.7
ENSMUST00000106973.1
ENSMUST00000144207.1
Anapc15


anaphase prompoting complex C subunit 15


chr18_+_56432116 0.439 ENSMUST00000070166.5
Gramd3
GRAM domain containing 3
chr18_+_61639542 0.439 ENSMUST00000183083.1
ENSMUST00000183087.1
Gm20748

predicted gene, 20748

chr18_-_56975333 0.437 ENSMUST00000139243.2
ENSMUST00000025488.8
C330018D20Rik

RIKEN cDNA C330018D20 gene

chrX_-_74246534 0.430 ENSMUST00000101454.2
ENSMUST00000033699.6
Flna

filamin, alpha

chrX_+_150589907 0.427 ENSMUST00000080884.4
Pfkfb1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr15_-_50890041 0.418 ENSMUST00000077935.5
Trps1
trichorhinophalangeal syndrome I (human)
chr12_+_3954943 0.417 ENSMUST00000020990.5
Pomc
pro-opiomelanocortin-alpha
chrX_-_139871637 0.407 ENSMUST00000033811.7
ENSMUST00000087401.5
Morc4

microrchidia 4

chr19_-_14598031 0.392 ENSMUST00000167776.2
Tle4
transducin-like enhancer of split 4, homolog of Drosophila E(spl)
chr15_-_102350692 0.388 ENSMUST00000041208.7
Aaas
achalasia, adrenocortical insufficiency, alacrimia
chr11_-_3931789 0.383 ENSMUST00000109992.1
ENSMUST00000109988.1
Tcn2

transcobalamin 2

chr10_+_127420867 0.380 ENSMUST00000064793.6
R3hdm2
R3H domain containing 2
chr15_-_13173607 0.379 ENSMUST00000036439.4
Cdh6
cadherin 6
chr15_-_42676967 0.378 ENSMUST00000022921.5
Angpt1
angiopoietin 1
chr19_-_14597983 0.373 ENSMUST00000052011.7
Tle4
transducin-like enhancer of split 4, homolog of Drosophila E(spl)
chr7_+_131542867 0.365 ENSMUST00000046093.5
Hmx3
H6 homeobox 3
chr5_+_63812447 0.355 ENSMUST00000081747.3
0610040J01Rik
RIKEN cDNA 0610040J01 gene
chr5_-_138170992 0.354 ENSMUST00000139983.1
Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
chr15_-_64922290 0.353 ENSMUST00000023007.5
Adcy8
adenylate cyclase 8
chr5_-_138171248 0.350 ENSMUST00000153867.1
Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
chr19_+_55895508 0.349 ENSMUST00000111646.1
Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr2_+_83724397 0.346 ENSMUST00000028499.4
ENSMUST00000141725.1
ENSMUST00000111740.2
Itgav


integrin alpha V


chr10_-_53647080 0.341 ENSMUST00000169866.1
Fam184a
family with sequence similarity 184, member A

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.4 13.5 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
1.6 4.8 GO:0061357 Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) positive regulation of Wnt protein secretion(GO:0061357)
1.6 4.7 GO:0035880 embryonic nail plate morphogenesis(GO:0035880) positive regulation of catagen(GO:0051795) frontal suture morphogenesis(GO:0060364)
1.5 12.2 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
1.5 4.5 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
1.2 7.1 GO:0006570 tyrosine metabolic process(GO:0006570)
1.1 6.9 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.8 6.7 GO:0003150 muscular septum morphogenesis(GO:0003150)
0.8 13.8 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.8 2.3 GO:0030916 otic vesicle formation(GO:0030916)
0.7 2.8 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.5 2.5 GO:2000987 positive regulation of fear response(GO:1903367) positive regulation of behavioral fear response(GO:2000987)
0.5 1.4 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.4 4.8 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.4 1.2 GO:0060166 olfactory pit development(GO:0060166)
0.4 3.5 GO:0010587 miRNA catabolic process(GO:0010587)
0.4 2.3 GO:0045218 zonula adherens maintenance(GO:0045218)
0.4 1.5 GO:0061743 motor learning(GO:0061743)
0.4 1.9 GO:0001661 conditioned taste aversion(GO:0001661) amygdala development(GO:0021764)
0.4 3.0 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.4 0.7 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747)
0.4 1.1 GO:0003162 atrioventricular node development(GO:0003162)
0.3 6.6 GO:0071803 keratinocyte development(GO:0003334) positive regulation of podosome assembly(GO:0071803)
0.3 2.7 GO:0009249 protein lipoylation(GO:0009249)
0.3 4.3 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.3 1.3 GO:0035553 oxidative single-stranded RNA demethylation(GO:0035553)
0.3 1.0 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743) alveolar secondary septum development(GO:0061144)
0.3 0.6 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
0.3 0.9 GO:0036233 glycine import(GO:0036233)
0.3 0.6 GO:1902256 apoptotic process involved in outflow tract morphogenesis(GO:0003275) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256)
0.3 0.9 GO:2001013 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204) epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.3 0.5 GO:1904956 regulation of midbrain dopaminergic neuron differentiation(GO:1904956)
0.3 0.8 GO:0016554 cytidine to uridine editing(GO:0016554)
0.3 3.3 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.2 1.7 GO:0032782 bile acid secretion(GO:0032782)
0.2 1.4 GO:0051798 positive regulation of hair follicle development(GO:0051798)
0.2 3.1 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213) regulation of dopamine receptor signaling pathway(GO:0060159)
0.2 0.9 GO:0018065 protein-cofactor linkage(GO:0018065)
0.2 4.2 GO:0007530 sex determination(GO:0007530)
0.2 1.0 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.2 1.0 GO:0052695 cellular glucuronidation(GO:0052695)
0.2 0.7 GO:0015889 cobalamin transport(GO:0015889)
0.2 2.7 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.2 1.2 GO:0021978 telencephalon regionalization(GO:0021978)
0.2 0.5 GO:0045113 regulation of integrin biosynthetic process(GO:0045113)
0.2 0.5 GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
0.2 0.5 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.2 0.3 GO:0090365 regulation of mRNA modification(GO:0090365)
0.1 0.7 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.1 3.8 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.1 1.6 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.1 0.8 GO:0043415 positive regulation of skeletal muscle tissue regeneration(GO:0043415)
0.1 0.4 GO:0030210 heparin biosynthetic process(GO:0030210) Tie signaling pathway(GO:0048014)
0.1 0.5 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.1 0.6 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.1 0.3 GO:0050748 negative regulation of receptor biosynthetic process(GO:0010871) transforming growth factor-beta secretion(GO:0038044) negative regulation of lipoprotein metabolic process(GO:0050748)
0.1 0.2 GO:0097155 fasciculation of sensory neuron axon(GO:0097155)
0.1 0.9 GO:0032049 cardiolipin biosynthetic process(GO:0032049)
0.1 0.3 GO:0009826 unidimensional cell growth(GO:0009826) susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.1 0.5 GO:0038032 termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.1 1.2 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.1 0.3 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.1 0.3 GO:0060023 soft palate development(GO:0060023)
0.1 0.3 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.1 3.8 GO:0006270 DNA replication initiation(GO:0006270)
0.1 0.3 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.1 1.1 GO:0060539 diaphragm development(GO:0060539)
0.1 1.0 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.1 0.5 GO:0015692 vanadium ion transport(GO:0015676) lead ion transport(GO:0015692)
0.1 10.1 GO:0048706 embryonic skeletal system development(GO:0048706)
0.1 0.2 GO:0042536 negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.1 1.2 GO:0030497 fatty acid elongation(GO:0030497)
0.1 2.2 GO:0033194 response to hydroperoxide(GO:0033194)
0.1 0.5 GO:0002326 B cell lineage commitment(GO:0002326)
0.1 0.6 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.1 2.7 GO:0097352 autophagosome maturation(GO:0097352)
0.1 0.8 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.1 0.8 GO:0043922 negative regulation by host of viral transcription(GO:0043922)
0.1 0.2 GO:0010360 negative regulation of anion channel activity(GO:0010360)
0.1 0.3 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.1 0.2 GO:0090324 negative regulation of oxidative phosphorylation(GO:0090324)
0.1 3.1 GO:0051693 actin filament capping(GO:0051693)
0.1 1.1 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.1 3.9 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.1 2.0 GO:0018345 protein palmitoylation(GO:0018345)
0.1 1.1 GO:0006337 nucleosome disassembly(GO:0006337)
0.1 1.9 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.1 0.2 GO:0048245 eosinophil chemotaxis(GO:0048245)
0.1 1.0 GO:0045332 phospholipid translocation(GO:0045332)
0.1 0.5 GO:0035372 protein localization to microtubule(GO:0035372)
0.1 2.8 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 0.9 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.1 0.8 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.1 1.1 GO:1901020 negative regulation of calcium ion transmembrane transporter activity(GO:1901020)
0.1 0.4 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1 0.3 GO:0016078 tRNA catabolic process(GO:0016078)
0.0 0.3 GO:0010908 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334)
0.0 0.4 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.0 0.6 GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization(GO:0060307)
0.0 0.1 GO:1904245 regulation of polynucleotide adenylyltransferase activity(GO:1904245)
0.0 4.1 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 1.9 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
0.0 0.2 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406)
0.0 0.3 GO:0071763 nuclear membrane organization(GO:0071763)
0.0 0.9 GO:0071384 cellular response to corticosteroid stimulus(GO:0071384) cellular response to glucocorticoid stimulus(GO:0071385)
0.0 0.2 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.0 0.8 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 1.1 GO:0060479 lung cell differentiation(GO:0060479) lung epithelial cell differentiation(GO:0060487)
0.0 0.2 GO:0009396 folic acid-containing compound biosynthetic process(GO:0009396)
0.0 0.6 GO:0045624 positive regulation of T-helper cell differentiation(GO:0045624)
0.0 0.1 GO:0043586 tongue development(GO:0043586)
0.0 0.1 GO:0045925 positive regulation of female receptivity(GO:0045925)
0.0 1.1 GO:0030901 midbrain development(GO:0030901)
0.0 0.7 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 0.8 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.5 GO:0006999 nuclear pore organization(GO:0006999)
0.0 0.5 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.0 0.1 GO:1900377 negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377)
0.0 1.1 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.0 0.1 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.0 1.1 GO:0071774 response to fibroblast growth factor(GO:0071774)
0.0 0.2 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0 0.3 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.0 1.9 GO:0043488 regulation of mRNA stability(GO:0043488)
0.0 0.1 GO:0051697 protein delipidation(GO:0051697)
0.0 1.4 GO:0030168 platelet activation(GO:0030168)
0.0 0.2 GO:0019388 galactose catabolic process(GO:0019388)
0.0 0.1 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.0 0.1 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0 0.4 GO:0007616 long-term memory(GO:0007616)
0.0 0.3 GO:0003351 epithelial cilium movement(GO:0003351)
0.0 2.3 GO:0030178 negative regulation of Wnt signaling pathway(GO:0030178)
0.0 0.7 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 0.8 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.0 0.1 GO:0072189 ureter development(GO:0072189)
0.0 0.2 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 0.6 GO:0009060 aerobic respiration(GO:0009060)
0.0 3.4 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 0.3 GO:0050873 brown fat cell differentiation(GO:0050873)
0.0 0.4 GO:0007566 embryo implantation(GO:0007566)
0.0 0.0 GO:0034285 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.5 GO:0032280 symmetric synapse(GO:0032280)
0.6 2.3 GO:0060187 cell pole(GO:0060187)
0.5 3.1 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.5 2.9 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.5 2.8 GO:0001674 female germ cell nucleus(GO:0001674)
0.3 1.2 GO:0033093 Weibel-Palade body(GO:0033093)
0.3 4.1 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.3 7.1 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.2 1.1 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.2 2.3 GO:0005915 zonula adherens(GO:0005915)
0.1 6.6 GO:0002102 podosome(GO:0002102)
0.1 0.7 GO:0072487 MSL complex(GO:0072487)
0.1 0.4 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.1 4.8 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 1.9 GO:0042788 polysomal ribosome(GO:0042788)
0.1 0.5 GO:0071438 NADPH oxidase complex(GO:0043020) invadopodium membrane(GO:0071438)
0.1 0.3 GO:0034684 integrin alphav-beta5 complex(GO:0034684)
0.1 13.7 GO:0000792 heterochromatin(GO:0000792)
0.1 0.5 GO:0070826 paraferritin complex(GO:0070826)
0.1 0.5 GO:0031523 Myb complex(GO:0031523)
0.1 0.5 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.1 3.0 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 2.4 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 0.5 GO:0033269 internode region of axon(GO:0033269)
0.1 0.5 GO:0016580 Sin3 complex(GO:0016580)
0.1 2.7 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 0.8 GO:0042555 MCM complex(GO:0042555)
0.1 0.1 GO:0044301 climbing fiber(GO:0044301)
0.1 0.5 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 1.1 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.6 GO:0033655 host cell cytoplasm(GO:0030430) host cell cytoplasm part(GO:0033655)
0.0 0.3 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.2 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0 0.3 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0 0.3 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 0.6 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.7 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.3 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.0 0.3 GO:0070852 cell body fiber(GO:0070852)
0.0 2.7 GO:0043198 dendritic shaft(GO:0043198)
0.0 11.1 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.6 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.3 GO:0045120 pronucleus(GO:0045120)
0.0 1.2 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 1.3 GO:0005902 microvillus(GO:0005902)
0.0 0.4 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.2 GO:0031045 dense core granule(GO:0031045)
0.0 0.2 GO:0071439 clathrin complex(GO:0071439)
0.0 1.0 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.5 GO:0097440 apical dendrite(GO:0097440)
0.0 1.9 GO:0000776 kinetochore(GO:0000776)
0.0 1.2 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.2 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.4 GO:0000786 nucleosome(GO:0000786)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 12.2 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
1.0 3.1 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.7 7.5 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.6 5.6 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.5 7.1 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.5 3.6 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.5 2.5 GO:0031628 opioid receptor binding(GO:0031628)
0.4 1.7 GO:0015254 glycerol channel activity(GO:0015254)
0.4 3.0 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.4 1.2 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.3 1.3 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.3 4.5 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.3 1.2 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.3 2.3 GO:0039706 co-receptor binding(GO:0039706)
0.2 0.5 GO:0070644 vitamin D response element binding(GO:0070644)
0.2 2.9 GO:0043522 leucine zipper domain binding(GO:0043522)
0.2 1.2 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.2 4.7 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 0.8 GO:0004126 cytidine deaminase activity(GO:0004126)
0.2 2.3 GO:0070097 delta-catenin binding(GO:0070097)
0.2 1.6 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.2 2.2 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.2 0.5 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.1 0.9 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 0.5 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.1 1.4 GO:0048185 activin binding(GO:0048185)
0.1 4.4 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 2.1 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 2.6 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 3.7 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 0.9 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.1 14.1 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.1 1.0 GO:0019865 immunoglobulin binding(GO:0019865)
0.1 0.7 GO:0031419 cobalamin binding(GO:0031419)
0.1 4.8 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 1.1 GO:1990405 protein antigen binding(GO:1990405)
0.1 2.8 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.5 GO:0015086 cadmium ion transmembrane transporter activity(GO:0015086) lead ion transmembrane transporter activity(GO:0015094) vanadium ion transmembrane transporter activity(GO:0015100) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.1 0.9 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.1 1.9 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 0.3 GO:0019960 C-X3-C chemokine binding(GO:0019960)
0.1 3.3 GO:0015144 carbohydrate transmembrane transporter activity(GO:0015144) carbohydrate transporter activity(GO:1901476)
0.1 0.8 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.1 0.6 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.1 0.5 GO:0070728 leucine binding(GO:0070728)
0.1 1.1 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 0.9 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 0.5 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 2.0 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 0.3 GO:0043532 angiostatin binding(GO:0043532)
0.1 0.4 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.1 0.4 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.1 1.9 GO:0017091 AU-rich element binding(GO:0017091)
0.1 1.0 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 0.2 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.1 1.2 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 0.1 GO:0008311 double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311)
0.1 1.0 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 0.3 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.1 0.8 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.4 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.0 0.6 GO:0005537 mannose binding(GO:0005537)
0.0 0.1 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.0 47.9 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.0 5.6 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.0 1.1 GO:0042605 peptide antigen binding(GO:0042605)
0.0 1.0 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.7 GO:0008483 transaminase activity(GO:0008483)
0.0 0.9 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0 0.1 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.0 0.6 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.0 0.1 GO:0008988 rRNA (adenine-N6-)-methyltransferase activity(GO:0008988)
0.0 1.0 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 5.5 GO:0000287 magnesium ion binding(GO:0000287)
0.0 1.6 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.4 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.2 GO:0042056 chemoattractant activity(GO:0042056)
0.0 0.3 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.1 GO:0047256 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
0.0 0.8 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 0.6 GO:0003690 double-stranded DNA binding(GO:0003690)
0.0 0.3 GO:0005521 lamin binding(GO:0005521)
0.0 0.4 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.5 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.1 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.0 0.2 GO:0005542 folic acid binding(GO:0005542)
0.0 2.1 GO:0051015 actin filament binding(GO:0051015)
0.0 1.7 GO:0003774 motor activity(GO:0003774)
0.0 0.6 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.4 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 0.3 GO:0005201 extracellular matrix structural constituent(GO:0005201)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 7.3 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 14.2 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 2.8 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.1 4.5 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.1 1.9 PID_MYC_PATHWAY C-MYC pathway
0.1 4.1 PID_BMP_PATHWAY BMP receptor signaling
0.1 2.8 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.1 3.6 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 1.6 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 2.3 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 3.1 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 0.5 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 0.9 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 3.8 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.0 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.5 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.3 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 0.8 PID_ATR_PATHWAY ATR signaling pathway
0.0 0.5 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.8 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 0.6 PID_TCPTP_PATHWAY Signaling events mediated by TCPTP
0.0 0.3 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.8 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 0.6 PID_PLK1_PATHWAY PLK1 signaling events
0.0 0.8 PID_AR_PATHWAY Coregulation of Androgen receptor activity

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 12.2 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.2 1.7 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.2 0.8 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.1 1.5 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.1 10.5 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.9 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.1 1.2 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.1 1.0 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.1 9.8 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 1.1 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 0.7 REACTOME_ACYL_CHAIN_REMODELLING_OF_PG Genes involved in Acyl chain remodelling of PG
0.1 0.5 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.8 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.5 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.0 2.3 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 1.3 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.9 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 1.2 REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.9 REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 0.7 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 3.3 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 2.0 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.3 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 1.1 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 0.6 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.7 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.6 REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 1.0 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.0 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.8 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 1.4 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.5 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.3 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.5 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.6 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.4 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.0 0.3 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.2 REACTOME_PECAM1_INTERACTIONS Genes involved in PECAM1 interactions