Motif ID: Foxd2

Z-value: 1.236


Transcription factors associated with Foxd2:

Gene SymbolEntrez IDGene Name
Foxd2 ENSMUSG00000055210.3 Foxd2



Activity profile for motif Foxd2.

activity profile for motif Foxd2


Sorted Z-values histogram for motif Foxd2

Sorted Z-values for motif Foxd2



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxd2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_104114088 7.942 ENSMUST00000031249.3
Sparcl1
SPARC-like 1
chr18_+_37504264 5.031 ENSMUST00000052179.6
Pcdhb20
protocadherin beta 20
chr10_+_67096456 4.870 ENSMUST00000174317.1
Jmjd1c
jumonji domain containing 1C
chrX_-_105929206 4.735 ENSMUST00000134381.1
ENSMUST00000154866.1
Atrx

alpha thalassemia/mental retardation syndrome X-linked homolog (human)

chr3_+_89520152 4.601 ENSMUST00000000811.7
Kcnn3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chrX_-_105929333 4.563 ENSMUST00000134507.1
ENSMUST00000137453.1
ENSMUST00000150914.1
Atrx


alpha thalassemia/mental retardation syndrome X-linked homolog (human)


chr14_+_101840602 4.562 ENSMUST00000159314.1
Lmo7
LIM domain only 7
chr14_-_30353468 4.558 ENSMUST00000112249.1
Cacna1d
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr7_-_61982348 4.267 ENSMUST00000181804.1
ENSMUST00000181187.1
A330076H08Rik

RIKEN cDNA A330076H08 gene

chr16_+_43508118 3.878 ENSMUST00000114690.1
Zbtb20
zinc finger and BTB domain containing 20
chr7_-_61982290 3.833 ENSMUST00000180481.1
A330076H08Rik
RIKEN cDNA A330076H08 gene
chr14_+_101840501 3.571 ENSMUST00000159026.1
Lmo7
LIM domain only 7
chr15_+_92597104 3.451 ENSMUST00000035399.8
Pdzrn4
PDZ domain containing RING finger 4
chr14_+_80000292 3.392 ENSMUST00000088735.3
Olfm4
olfactomedin 4
chr18_+_37513652 3.344 ENSMUST00000061405.4
Pcdhb21
protocadherin beta 21
chrX_-_105929397 3.166 ENSMUST00000113573.1
ENSMUST00000130980.1
Atrx

alpha thalassemia/mental retardation syndrome X-linked homolog (human)

chr18_+_51117754 2.625 ENSMUST00000116639.2
Prr16
proline rich 16
chr13_+_16014457 2.497 ENSMUST00000164993.1
Inhba
inhibin beta-A
chr17_-_35046726 2.447 ENSMUST00000097338.4
Msh5
mutS homolog 5 (E. coli)
chr7_-_14562171 2.399 ENSMUST00000181796.1
Vmn1r90
vomeronasal 1 receptor 90
chr1_-_157256682 2.362 ENSMUST00000134543.1
Rasal2
RAS protein activator like 2
chr16_+_43235856 2.360 ENSMUST00000146708.1
Zbtb20
zinc finger and BTB domain containing 20
chr2_-_45110336 2.325 ENSMUST00000028229.6
ENSMUST00000152232.1
Zeb2

zinc finger E-box binding homeobox 2

chr5_-_103100054 2.311 ENSMUST00000112848.1
Mapk10
mitogen-activated protein kinase 10
chr4_-_14621805 2.258 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chrX_+_159697308 2.248 ENSMUST00000123433.1
Sh3kbp1
SH3-domain kinase binding protein 1
chr13_+_83732438 2.131 ENSMUST00000182701.1
C130071C03Rik
RIKEN cDNA C130071C03 gene
chr19_+_26748268 2.127 ENSMUST00000175791.1
ENSMUST00000176698.1
ENSMUST00000177252.1
ENSMUST00000176475.1
ENSMUST00000112637.2
Smarca2




SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2




chr9_-_20879718 2.082 ENSMUST00000043726.6
Angptl6
angiopoietin-like 6
chr5_+_107497762 2.022 ENSMUST00000152474.1
ENSMUST00000060553.7
A830010M20Rik

RIKEN cDNA A830010M20 gene

chr6_+_13069758 1.988 ENSMUST00000124234.1
ENSMUST00000142211.1
ENSMUST00000031556.7
Tmem106b


transmembrane protein 106B


chr9_-_89092835 1.972 ENSMUST00000167113.1
Trim43b
tripartite motif-containing 43B
chr5_+_107497718 1.684 ENSMUST00000112671.2
A830010M20Rik
RIKEN cDNA A830010M20 gene
chr11_+_97801917 1.626 ENSMUST00000127033.2
Lasp1
LIM and SH3 protein 1
chr16_-_16527364 1.615 ENSMUST00000069284.7
Fgd4
FYVE, RhoGEF and PH domain containing 4
chr9_-_95750335 1.579 ENSMUST00000053785.3
Trpc1
transient receptor potential cation channel, subfamily C, member 1
chr10_+_42860776 1.547 ENSMUST00000105494.1
Scml4
sex comb on midleg-like 4 (Drosophila)
chr16_-_4880284 1.408 ENSMUST00000037843.6
Ubald1
UBA-like domain containing 1
chr1_-_165934900 1.406 ENSMUST00000069609.5
ENSMUST00000111427.2
ENSMUST00000111426.4
Pou2f1


POU domain, class 2, transcription factor 1


chr11_-_69369377 1.393 ENSMUST00000092971.6
ENSMUST00000108661.1
Chd3

chromodomain helicase DNA binding protein 3

chr2_-_73312701 1.372 ENSMUST00000058615.9
Cir1
corepressor interacting with RBPJ, 1
chr12_-_101958148 1.261 ENSMUST00000159883.1
ENSMUST00000160251.1
ENSMUST00000161011.1
ENSMUST00000021606.5
Atxn3



ataxin 3



chr2_-_122702615 1.225 ENSMUST00000005952.4
ENSMUST00000099457.3
Slc30a4

solute carrier family 30 (zinc transporter), member 4

chr6_+_136518820 1.224 ENSMUST00000032335.6
Atf7ip
activating transcription factor 7 interacting protein
chr13_-_97747373 1.170 ENSMUST00000123535.1
5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr10_-_128744014 1.161 ENSMUST00000026414.7
Dgka
diacylglycerol kinase, alpha
chr2_+_120977017 1.111 ENSMUST00000067582.7
Tmem62
transmembrane protein 62
chr14_-_52213379 1.108 ENSMUST00000140603.1
Chd8
chromodomain helicase DNA binding protein 8
chr1_-_126830632 1.092 ENSMUST00000112583.1
ENSMUST00000094609.3
Nckap5

NCK-associated protein 5

chr1_-_37496095 1.063 ENSMUST00000148047.1
ENSMUST00000143636.1
Mgat4a

mannoside acetylglucosaminyltransferase 4, isoenzyme A

chr8_-_123754138 1.057 ENSMUST00000181805.1
4732419C18Rik
RIKEN cDNA 4732419C18 gene
chr1_-_170867761 1.052 ENSMUST00000027974.6
Atf6
activating transcription factor 6
chr19_-_29753600 1.010 ENSMUST00000175764.1
9930021J03Rik
RIKEN cDNA 9930021J03 gene
chr9_+_54980880 0.991 ENSMUST00000093844.3
Chrna5
cholinergic receptor, nicotinic, alpha polypeptide 5
chr16_+_13986596 0.900 ENSMUST00000056521.5
ENSMUST00000118412.1
ENSMUST00000131608.1
2900011O08Rik


RIKEN cDNA 2900011O08 gene


chr1_-_57970032 0.886 ENSMUST00000159826.1
Kctd18
potassium channel tetramerisation domain containing 18
chr6_-_54972603 0.885 ENSMUST00000060655.8
Nod1
nucleotide-binding oligomerization domain containing 1
chr18_+_37674303 0.768 ENSMUST00000073447.5
Pcdhga9
protocadherin gamma subfamily A, 9
chr7_+_43634718 0.764 ENSMUST00000032663.8
Ceacam18
carcinoembryonic antigen-related cell adhesion molecule 18
chr1_-_132367879 0.763 ENSMUST00000142609.1
Tmcc2
transmembrane and coiled-coil domains 2
chr1_-_126830786 0.742 ENSMUST00000162646.1
Nckap5
NCK-associated protein 5
chr14_-_70630149 0.721 ENSMUST00000022694.9
Dmtn
dematin actin binding protein
chr12_+_103434211 0.720 ENSMUST00000079294.5
ENSMUST00000076788.5
ENSMUST00000076702.5
ENSMUST00000066701.6
ENSMUST00000085065.5
ENSMUST00000140838.1
Ifi27





interferon, alpha-inducible protein 27





chr11_+_75650501 0.654 ENSMUST00000102505.3
Myo1c
myosin IC
chr4_+_150087365 0.636 ENSMUST00000094451.3
Gpr157
G protein-coupled receptor 157
chr1_+_172698046 0.621 ENSMUST00000038495.3
Crp
C-reactive protein, pentraxin-related
chr7_-_87493371 0.617 ENSMUST00000004770.5
Tyr
tyrosinase
chr18_+_37725706 0.613 ENSMUST00000066149.6
Pcdhga9
protocadherin gamma subfamily A, 9
chr14_+_26259109 0.560 ENSMUST00000174494.1
Duxbl3
double homeobox B-like 3
chr4_-_14621669 0.534 ENSMUST00000143105.1
Slc26a7
solute carrier family 26, member 7
chr19_+_57452900 0.495 ENSMUST00000026073.6
ENSMUST00000026072.3
Trub1

TruB pseudouridine (psi) synthase homolog 1 (E. coli)

chr1_+_171840607 0.486 ENSMUST00000136479.1
ENSMUST00000042302.6
Cd84

CD84 antigen

chr13_+_5861489 0.482 ENSMUST00000000080.6
Klf6
Kruppel-like factor 6
chr4_+_32243733 0.431 ENSMUST00000165661.1
D130062J21Rik
RIKEN cDNA D130062J21 gene
chr6_+_77242644 0.381 ENSMUST00000159616.1
Lrrtm1
leucine rich repeat transmembrane neuronal 1
chr15_-_98607611 0.371 ENSMUST00000096224.4
Adcy6
adenylate cyclase 6
chr1_-_57970104 0.365 ENSMUST00000114410.3
Kctd18
potassium channel tetramerisation domain containing 18
chr17_-_78418083 0.363 ENSMUST00000070039.7
ENSMUST00000112487.1
Fez2

fasciculation and elongation protein zeta 2 (zygin II)

chr9_+_78109188 0.358 ENSMUST00000118869.1
ENSMUST00000125615.1
Ick

intestinal cell kinase

chr10_+_93488766 0.345 ENSMUST00000129421.1
Hal
histidine ammonia lyase
chr5_-_31295862 0.340 ENSMUST00000041266.7
ENSMUST00000172435.1
Fndc4

fibronectin type III domain containing 4

chr9_-_78109020 0.329 ENSMUST00000001402.7
Fbxo9
f-box protein 9
chr15_+_3270767 0.307 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
Sepp1



selenoprotein P, plasma, 1



chr18_-_6516089 0.305 ENSMUST00000115870.2
Epc1
enhancer of polycomb homolog 1 (Drosophila)
chr15_+_78935177 0.292 ENSMUST00000145157.1
ENSMUST00000123013.1
Nol12

nucleolar protein 12

chr5_+_148265202 0.289 ENSMUST00000110515.2
Mtus2
microtubule associated tumor suppressor candidate 2
chr6_+_77242715 0.287 ENSMUST00000161677.1
Lrrtm1
leucine rich repeat transmembrane neuronal 1
chr7_-_127195875 0.267 ENSMUST00000035771.3
ENSMUST00000166791.1
Cd2bp2

CD2 antigen (cytoplasmic tail) binding protein 2

chr9_-_55283582 0.250 ENSMUST00000114306.1
ENSMUST00000164721.1
Nrg4

neuregulin 4

chr11_+_43682038 0.228 ENSMUST00000094294.4
Pwwp2a
PWWP domain containing 2A
chr10_-_89621253 0.214 ENSMUST00000020102.7
Slc17a8
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8
chr4_+_115737738 0.210 ENSMUST00000106525.2
Efcab14
EF-hand calcium binding domain 14
chr3_+_76075583 0.196 ENSMUST00000160261.1
Fstl5
follistatin-like 5
chr6_+_61180313 0.187 ENSMUST00000126214.1
Ccser1
coiled-coil serine rich 1
chr7_-_99980431 0.173 ENSMUST00000080817.4
Rnf169
ring finger protein 169
chr17_-_56276750 0.155 ENSMUST00000058136.8
Ticam1
toll-like receptor adaptor molecule 1
chr12_-_110840905 0.153 ENSMUST00000177224.1
ENSMUST00000084974.4
ENSMUST00000070565.8
Stk30


serine/threonine kinase 30


chr10_-_11080956 0.111 ENSMUST00000105560.1
Grm1
glutamate receptor, metabotropic 1
chr2_-_86347764 0.111 ENSMUST00000099894.2
Olfr1055
olfactory receptor 1055
chr5_-_120612558 0.081 ENSMUST00000140554.1
ENSMUST00000031599.2
ENSMUST00000177800.1
1110008J03Rik


RIKEN cDNA 1110008J03 gene


chr15_+_100154379 0.078 ENSMUST00000023768.6
ENSMUST00000108971.2
Dip2b

DIP2 disco-interacting protein 2 homolog B (Drosophila)

chr5_+_148265265 0.047 ENSMUST00000071878.5
Mtus2
microtubule associated tumor suppressor candidate 2
chr6_+_11926758 0.030 ENSMUST00000133776.1
Phf14
PHD finger protein 14
chr4_+_115737754 0.010 ENSMUST00000106522.2
Efcab14
EF-hand calcium binding domain 14
chr5_+_24393640 0.000 ENSMUST00000138168.1
ENSMUST00000115077.1
Abcb8

ATP-binding cassette, sub-family B (MDR/TAP), member 8


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 12.5 GO:0097393 post-embryonic appendage morphogenesis(GO:0035120) post-embryonic limb morphogenesis(GO:0035127) post-embryonic forelimb morphogenesis(GO:0035128) telomeric repeat-containing RNA transcription(GO:0097393) telomeric repeat-containing RNA transcription from RNA pol II promoter(GO:0097394) regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901580) negative regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901581) positive regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901582)
1.1 4.6 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.7 4.9 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.5 2.5 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.5 2.4 GO:0051026 chiasma assembly(GO:0051026)
0.4 2.8 GO:0019532 oxalate transport(GO:0019532)
0.4 2.3 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.4 2.3 GO:0007258 JUN phosphorylation(GO:0007258)
0.3 0.9 GO:1903976 negative regulation of glial cell migration(GO:1903976)
0.2 0.7 GO:0035585 calcium-mediated signaling using extracellular calcium source(GO:0035585)
0.2 2.1 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.2 1.4 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.2 1.6 GO:0030035 microspike assembly(GO:0030035)
0.2 0.9 GO:0042228 interleukin-8 biosynthetic process(GO:0042228)
0.2 0.5 GO:2001180 regulation of interleukin-18 production(GO:0032661) negative regulation of interleukin-18 production(GO:0032701) negative regulation of interleukin-10 secretion(GO:2001180)
0.2 1.6 GO:0046541 saliva secretion(GO:0046541)
0.2 6.4 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 1.2 GO:0061088 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.1 0.7 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.1 0.4 GO:0035811 negative regulation of urine volume(GO:0035811)
0.1 1.3 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.1 2.6 GO:0045793 positive regulation of cell size(GO:0045793)
0.1 1.0 GO:0035095 behavioral response to nicotine(GO:0035095)
0.1 0.6 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.1 1.1 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.1 1.2 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.1 0.3 GO:0006547 histidine metabolic process(GO:0006547) imidazole-containing compound catabolic process(GO:0052805)
0.1 0.5 GO:1990481 mRNA pseudouridine synthesis(GO:1990481)
0.1 1.1 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.1 1.2 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.1 3.4 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1 0.4 GO:0035720 intraciliary anterograde transport(GO:0035720)
0.1 9.0 GO:0007416 synapse assembly(GO:0007416)
0.0 0.6 GO:0060019 radial glial cell differentiation(GO:0060019)
0.0 2.5 GO:0007606 sensory perception of chemical stimulus(GO:0007606)
0.0 0.6 GO:0042438 melanin biosynthetic process(GO:0042438)
0.0 2.4 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)
0.0 3.2 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.0 2.0 GO:0032418 lysosome localization(GO:0032418)
0.0 0.1 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.0 0.3 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.7 GO:0046825 regulation of protein export from nucleus(GO:0046825)
0.0 0.8 GO:0042982 amyloid precursor protein metabolic process(GO:0042982)
0.0 0.1 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)
0.0 1.1 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 0.0 GO:0035790 platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 12.5 GO:1990421 subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707)
0.8 2.5 GO:0043512 inhibin A complex(GO:0043512)
0.5 4.6 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.2 3.4 GO:0042581 specific granule(GO:0042581)
0.2 0.7 GO:0045160 myosin I complex(GO:0045160)
0.2 0.7 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.2 2.4 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 2.1 GO:0071564 npBAF complex(GO:0071564)
0.1 1.0 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 1.3 GO:0042405 nuclear inclusion body(GO:0042405)
0.1 2.4 GO:0000795 synaptonemal complex(GO:0000795)
0.1 7.6 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 6.8 GO:0030175 filopodium(GO:0030175)
0.1 0.3 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 1.4 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 0.2 GO:0097450 astrocyte end-foot(GO:0097450)
0.0 1.6 GO:0043034 costamere(GO:0043034)
0.0 0.4 GO:0031528 microvillus membrane(GO:0031528)
0.0 1.1 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 0.6 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.4 GO:0097542 ciliary tip(GO:0097542)
0.0 7.9 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 1.6 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.2 GO:0097342 ripoptosome(GO:0097342)
0.0 0.6 GO:0060170 ciliary membrane(GO:0060170)
0.0 2.2 GO:0030139 endocytic vesicle(GO:0030139)
0.0 1.4 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 2.3 GO:0043204 perikaryon(GO:0043204)
0.0 3.7 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.7 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.3 GO:0005682 U5 snRNP(GO:0005682)
0.0 9.0 GO:0005887 integral component of plasma membrane(GO:0005887)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 12.5 GO:0015616 DNA translocase activity(GO:0015616)
1.2 4.6 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.6 2.3 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.6 4.6 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.4 2.5 GO:0070699 type II activin receptor binding(GO:0070699)
0.3 2.4 GO:0030983 mismatched DNA binding(GO:0030983)
0.3 4.9 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.3 2.8 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.2 1.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.2 6.7 GO:0042805 actinin binding(GO:0042805)
0.2 0.6 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.2 0.9 GO:0050700 CARD domain binding(GO:0050700)
0.2 1.3 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.1 7.9 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 1.6 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 1.2 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 1.0 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 0.6 GO:0001849 complement component C1q binding(GO:0001849)
0.1 0.3 GO:0016841 ammonia-lyase activity(GO:0016841)
0.1 1.1 GO:0035497 cAMP response element binding(GO:0035497)
0.1 0.4 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.1 2.3 GO:0070412 R-SMAD binding(GO:0070412)
0.1 1.4 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.1 1.1 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.7 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.7 GO:0005521 lamin binding(GO:0005521)
0.0 2.1 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 6.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.5 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.1 GO:0001639 PLC activating G-protein coupled glutamate receptor activity(GO:0001639) G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.0 0.1 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 3.2 GO:0051015 actin filament binding(GO:0051015)
0.0 0.7 GO:0030507 spectrin binding(GO:0030507)
0.0 2.2 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.2 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.3 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.1 2.5 PID_ALK1_PATHWAY ALK1 signaling events
0.0 7.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.4 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 2.2 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 0.2 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 2.1 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 0.4 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.5 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.7 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 1.4 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 0.5 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.6 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 0.7 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 1.1 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.5 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.1 3.2 REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.1 1.0 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 1.1 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 2.2 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 1.1 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 1.4 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 4.6 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.0 1.2 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 4.1 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 2.4 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.4 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 2.3 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.2 REACTOME_TRAF6_MEDIATED_INDUCTION_OF_TAK1_COMPLEX Genes involved in TRAF6 mediated induction of TAK1 complex
0.0 1.6 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 0.7 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.1 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.2 REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING Genes involved in SHC1 events in ERBB4 signaling