Motif ID: Bhlhe40

Z-value: 0.607


Transcription factors associated with Bhlhe40:

Gene SymbolEntrez IDGene Name
Bhlhe40 ENSMUSG00000030103.5 Bhlhe40

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Bhlhe40mm10_v2_chr6_+_108660772_1086608740.542.0e-02Click!


Activity profile for motif Bhlhe40.

activity profile for motif Bhlhe40


Sorted Z-values histogram for motif Bhlhe40

Sorted Z-values for motif Bhlhe40



Network of associatons between targets according to the STRING database.



First level regulatory network of Bhlhe40

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_148039097 2.459 ENSMUST00000141283.1
Mthfr
5,10-methylenetetrahydrofolate reductase
chr4_-_148038769 1.936 ENSMUST00000030879.5
ENSMUST00000137724.1
Clcn6

chloride channel 6

chr4_+_148039035 1.918 ENSMUST00000097788.4
Mthfr
5,10-methylenetetrahydrofolate reductase
chr7_+_121707189 1.604 ENSMUST00000065310.2
1700069B07Rik
RIKEN cDNA 1700069B07 gene
chr2_+_30286406 1.176 ENSMUST00000138666.1
ENSMUST00000113634.2
Nup188

nucleoporin 188

chr16_-_44139630 1.115 ENSMUST00000137557.1
ENSMUST00000147025.1
Atp6v1a

ATPase, H+ transporting, lysosomal V1 subunit A

chr16_-_44139003 1.105 ENSMUST00000124102.1
Atp6v1a
ATPase, H+ transporting, lysosomal V1 subunit A
chr5_-_123572976 1.035 ENSMUST00000031388.8
Vps33a
vacuolar protein sorting 33A (yeast)
chr5_+_65199691 0.953 ENSMUST00000041892.8
Wdr19
WD repeat domain 19
chr12_-_79296266 0.933 ENSMUST00000021547.6
Zfyve26
zinc finger, FYVE domain containing 26
chr12_-_3426700 0.845 ENSMUST00000180149.1
1110002L01Rik
RIKEN cDNA 1110002L01 gene
chr2_+_30286383 0.801 ENSMUST00000064447.5
Nup188
nucleoporin 188
chr8_+_85036906 0.714 ENSMUST00000093360.4
Tnpo2
transportin 2 (importin 3, karyopherin beta 2b)
chr11_-_75454656 0.667 ENSMUST00000173320.1
Wdr81
WD repeat domain 81
chr7_-_35802968 0.657 ENSMUST00000061586.4
Zfp507
zinc finger protein 507
chr8_+_85037151 0.654 ENSMUST00000166592.1
Tnpo2
transportin 2 (importin 3, karyopherin beta 2b)
chr7_+_35802593 0.652 ENSMUST00000052454.2
E130304I02Rik
RIKEN cDNA E130304I02 gene
chr1_-_152766323 0.620 ENSMUST00000111857.1
Rgl1
ral guanine nucleotide dissociation stimulator,-like 1
chr16_+_8830093 0.614 ENSMUST00000023150.5
1810013L24Rik
RIKEN cDNA 1810013L24 gene
chr1_-_152766281 0.561 ENSMUST00000111859.1
ENSMUST00000148865.1
Rgl1

ral guanine nucleotide dissociation stimulator,-like 1

chr16_+_5050012 0.550 ENSMUST00000052449.5
Ubn1
ubinuclein 1
chr11_+_55204319 0.548 ENSMUST00000108872.2
ENSMUST00000147506.1
ENSMUST00000020499.7
Slc36a1


solute carrier family 36 (proton/amino acid symporter), member 1


chr4_-_141790891 0.545 ENSMUST00000038014.4
ENSMUST00000153880.1
Dnajc16

DnaJ (Hsp40) homolog, subfamily C, member 16

chr7_-_126583523 0.529 ENSMUST00000125508.1
ENSMUST00000147086.1
ENSMUST00000150587.1
Cln3


ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease)


chrX_-_152327430 0.453 ENSMUST00000181635.1
ENSMUST00000141922.1
ENSMUST00000154085.1
ENSMUST00000148326.1
ENSMUST00000135115.1
ENSMUST00000149098.1
2900056M20Rik





RIKEN cDNA 2900056M20 gene





chr9_+_108002501 0.431 ENSMUST00000035214.4
ENSMUST00000175874.1
Ip6k1

inositol hexaphosphate kinase 1

chr12_+_86947343 0.418 ENSMUST00000038369.4
2310044G17Rik
RIKEN cDNA 2310044G17 gene
chr10_+_79854658 0.374 ENSMUST00000171599.1
ENSMUST00000095457.4
Ptbp1

polypyrimidine tract binding protein 1

chr3_-_95106907 0.372 ENSMUST00000107233.2
Pip5k1a
phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha
chr7_+_82648595 0.370 ENSMUST00000141726.1
ENSMUST00000179489.1
ENSMUST00000039881.3
Eftud1


elongation factor Tu GTP binding domain containing 1


chr2_-_30286312 0.363 ENSMUST00000100219.3
Dolk
dolichol kinase
chr10_+_79854618 0.353 ENSMUST00000165704.1
Ptbp1
polypyrimidine tract binding protein 1
chr16_-_44139196 0.344 ENSMUST00000063661.6
ENSMUST00000114666.2
Atp6v1a

ATPase, H+ transporting, lysosomal V1 subunit A

chr4_-_137048695 0.344 ENSMUST00000049583.7
Zbtb40
zinc finger and BTB domain containing 40
chr2_+_166805506 0.343 ENSMUST00000099078.3
Arfgef2
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
chr18_+_31609512 0.333 ENSMUST00000164667.1
B930094E09Rik
RIKEN cDNA B930094E09 gene
chr3_-_95106779 0.332 ENSMUST00000005768.7
ENSMUST00000107232.2
ENSMUST00000107236.2
Pip5k1a


phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha


chr9_-_97111117 0.330 ENSMUST00000085206.4
Slc25a36
solute carrier family 25, member 36
chr6_+_72097561 0.325 ENSMUST00000069994.4
ENSMUST00000114112.1
St3gal5

ST3 beta-galactoside alpha-2,3-sialyltransferase 5

chr9_-_44361625 0.305 ENSMUST00000034644.8
Vps11
vacuolar protein sorting 11 (yeast)
chr7_+_128744870 0.298 ENSMUST00000042942.8
Sec23ip
Sec23 interacting protein
chr11_+_97450136 0.287 ENSMUST00000107601.1
Arhgap23
Rho GTPase activating protein 23
chr17_-_12769605 0.272 ENSMUST00000024599.7
Igf2r
insulin-like growth factor 2 receptor
chr16_+_5233615 0.267 ENSMUST00000100196.2
ENSMUST00000049207.8
Alg1

asparagine-linked glycosylation 1 (beta-1,4-mannosyltransferase)

chr4_-_48473403 0.265 ENSMUST00000164866.1
ENSMUST00000030030.8
Tex10

testis expressed gene 10

chr12_+_3426857 0.257 ENSMUST00000111215.3
ENSMUST00000092003.5
ENSMUST00000144247.2
ENSMUST00000153102.2
Asxl2



additional sex combs like 2 (Drosophila)



chr3_-_90052463 0.256 ENSMUST00000029553.9
ENSMUST00000064639.8
ENSMUST00000090908.6
Ubap2l


ubiquitin associated protein 2-like


chr12_-_84450944 0.245 ENSMUST00000085192.5
Aldh6a1
aldehyde dehydrogenase family 6, subfamily A1
chr6_+_116338013 0.243 ENSMUST00000079012.6
ENSMUST00000101032.3
March8

membrane-associated ring finger (C3HC4) 8

chr18_-_20896078 0.238 ENSMUST00000025177.6
ENSMUST00000097658.1
Trappc8

trafficking protein particle complex 8

chr6_+_17693905 0.218 ENSMUST00000115420.1
St7
suppression of tumorigenicity 7
chr11_-_110095937 0.212 ENSMUST00000106664.3
ENSMUST00000046223.7
ENSMUST00000106662.1
Abca8a


ATP-binding cassette, sub-family A (ABC1), member 8a


chr11_+_75348433 0.211 ENSMUST00000044530.2
Smyd4
SET and MYND domain containing 4
chr6_+_17693965 0.196 ENSMUST00000115419.1
St7
suppression of tumorigenicity 7
chr3_-_107333289 0.196 ENSMUST00000061772.9
Rbm15
RNA binding motif protein 15
chr5_+_123252087 0.191 ENSMUST00000121964.1
Wdr66
WD repeat domain 66
chr8_+_111033890 0.168 ENSMUST00000034441.7
Aars
alanyl-tRNA synthetase
chr16_-_5049882 0.166 ENSMUST00000023189.7
ENSMUST00000115844.1
Glyr1

glyoxylate reductase 1 homolog (Arabidopsis)

chr7_+_27195781 0.158 ENSMUST00000108379.1
ENSMUST00000179391.1
BC024978

cDNA sequence BC024978

chr10_+_78574492 0.139 ENSMUST00000105384.3
Ilvbl
ilvB (bacterial acetolactate synthase)-like
chr3_+_96727611 0.139 ENSMUST00000029740.9
Rnf115
ring finger protein 115
chr16_-_92466081 0.139 ENSMUST00000060005.8
Rcan1
regulator of calcineurin 1
chr8_+_25601591 0.137 ENSMUST00000155861.1
Whsc1l1
Wolf-Hirschhorn syndrome candidate 1-like 1 (human)
chr17_+_70561739 0.132 ENSMUST00000097288.2
Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr13_-_48625571 0.117 ENSMUST00000035824.9
Ptpdc1
protein tyrosine phosphatase domain containing 1
chrX_-_7188713 0.116 ENSMUST00000004428.7
Clcn5
chloride channel 5
chr19_+_29522263 0.114 ENSMUST00000043610.6
ENSMUST00000162184.1
C030046E11Rik

RIKEN cDNA C030046E11 gene

chr3_+_89202916 0.097 ENSMUST00000077367.4
ENSMUST00000167998.1
Gba

glucosidase, beta, acid

chr14_+_26579535 0.093 ENSMUST00000037585.7
Dennd6a
DENN/MADD domain containing 6A
chr6_+_17694005 0.093 ENSMUST00000081635.6
ENSMUST00000052113.5
St7

suppression of tumorigenicity 7

chr11_+_3649494 0.090 ENSMUST00000093389.2
Morc2a
microrchidia 2A
chr6_+_17694167 0.079 ENSMUST00000115418.1
St7
suppression of tumorigenicity 7
chr1_+_155158703 0.075 ENSMUST00000027743.7
Stx6
syntaxin 6
chr18_-_31609893 0.064 ENSMUST00000060396.6
Slc25a46
solute carrier family 25, member 46
chr3_-_96727453 0.061 ENSMUST00000141377.1
ENSMUST00000125183.1
Polr3c

polymerase (RNA) III (DNA directed) polypeptide C

chr3_-_10440054 0.058 ENSMUST00000099223.4
ENSMUST00000029047.6
Snx16

sorting nexin 16

chr19_-_7241216 0.051 ENSMUST00000025675.9
Naa40
N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae)
chr11_-_75348261 0.046 ENSMUST00000000767.5
ENSMUST00000092907.5
Rpa1

replication protein A1

chr6_-_35133731 0.032 ENSMUST00000114993.2
ENSMUST00000114989.2
ENSMUST00000044163.6
Cnot4


CCR4-NOT transcription complex, subunit 4


chr8_+_3500451 0.031 ENSMUST00000004683.6
ENSMUST00000160338.1
Mcoln1

mucolipin 1

chr10_-_80139347 0.023 ENSMUST00000105369.1
Dos
downstream of Stk11
chrX_-_136203637 0.022 ENSMUST00000151592.1
ENSMUST00000131510.1
ENSMUST00000066819.4
Tceal5


transcription elongation factor A (SII)-like 5


chr8_-_84846860 0.017 ENSMUST00000003912.6
Calr
calreticulin

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.4 GO:0070829 heterochromatin maintenance(GO:0070829)
0.4 2.0 GO:0090521 glomerular visceral epithelial cell migration(GO:0090521)
0.2 1.0 GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830) myotome development(GO:0061055)
0.1 0.5 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
0.1 2.6 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.1 1.4 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.1 1.0 GO:0035751 regulation of lysosomal lumen pH(GO:0035751)
0.1 0.3 GO:0072531 pyrimidine-containing compound transmembrane transport(GO:0072531)
0.1 0.2 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.1 0.5 GO:0015808 L-alanine transport(GO:0015808)
0.1 0.2 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.1 0.3 GO:1903012 positive regulation of bone development(GO:1903012)
0.0 0.2 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
0.0 2.1 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 0.7 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0 0.3 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.0 0.4 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.2 GO:0030242 pexophagy(GO:0030242)
0.0 0.3 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.0 0.1 GO:1903061 regulation of protein lipidation(GO:1903059) positive regulation of protein lipidation(GO:1903061) positive regulation of neuronal action potential(GO:1904457)
0.0 0.3 GO:0001675 acrosome assembly(GO:0001675)
0.0 0.7 GO:0097178 ruffle assembly(GO:0097178)
0.0 0.2 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.5 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)
0.0 0.1 GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin(GO:2000049)
0.0 0.3 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.1 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 0.1 GO:0070842 aggresome assembly(GO:0070842)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.0 GO:0044611 nuclear pore inner ring(GO:0044611)
0.3 2.5 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.2 1.3 GO:0033263 CORVET complex(GO:0033263)
0.1 1.0 GO:0030991 intraciliary transport particle A(GO:0030991)
0.1 0.3 GO:0032280 symmetric synapse(GO:0032280)
0.0 0.7 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.1 GO:0043202 lysosomal lumen(GO:0043202)
0.0 0.3 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.7 GO:0044306 neuron projection terminus(GO:0044306)
0.0 0.2 GO:0030008 TRAPP complex(GO:0030008)
0.0 3.3 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 0.3 GO:0070971 endoplasmic reticulum exit site(GO:0070971)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.4 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.2 1.2 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.2 0.5 GO:0015173 hydrogen:amino acid symporter activity(GO:0005280) aromatic amino acid transmembrane transporter activity(GO:0015173)
0.1 2.1 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 0.7 GO:0001069 regulatory region RNA binding(GO:0001069)
0.1 2.5 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 0.4 GO:0000832 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.1 0.7 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.1 2.0 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 0.2 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.1 0.2 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.1 1.4 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.2 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.3 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.1 GO:0004348 glucosylceramidase activity(GO:0004348)
0.0 0.1 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 0.9 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.3 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.1 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.0 0.3 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)
0.0 0.3 GO:0008373 sialyltransferase activity(GO:0008373)
0.0 0.3 GO:0000030 mannosyltransferase activity(GO:0000030)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.5 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.1 4.2 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 2.0 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.4 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.3 REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.2 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.0 REACTOME_TRANSFERRIN_ENDOCYTOSIS_AND_RECYCLING Genes involved in Transferrin endocytosis and recycling