Motif ID: Nkx1-1_Nkx1-2

Z-value: 0.386

Transcription factors associated with Nkx1-1_Nkx1-2:

Gene SymbolEntrez IDGene Name
Nkx1-1 ENSMUSG00000029112.5 Nkx1-1
Nkx1-2 ENSMUSG00000048528.7 Nkx1-2






Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx1-1_Nkx1-2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_55782500 2.307 ENSMUST00000075422.4
Mab21l1
mab-21-like 1 (C. elegans)
chrX_-_60893430 2.112 ENSMUST00000135107.2
Sox3
SRY-box containing gene 3
chr6_-_124779686 1.328 ENSMUST00000147669.1
ENSMUST00000128697.1
ENSMUST00000032218.3
ENSMUST00000112475.2
Lrrc23



leucine rich repeat containing 23



chr6_-_23248264 1.131 ENSMUST00000031709.5
Fezf1
Fez family zinc finger 1
chr7_-_143460989 0.739 ENSMUST00000167912.1
ENSMUST00000037287.6
Cdkn1c

cyclin-dependent kinase inhibitor 1C (P57)

chr5_+_140607334 0.660 ENSMUST00000031555.1
Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr6_+_29694204 0.660 ENSMUST00000046750.7
ENSMUST00000115250.3
Tspan33

tetraspanin 33

chr13_-_102905740 0.629 ENSMUST00000167462.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr14_-_8666236 0.613 ENSMUST00000102996.3
4930452B06Rik
RIKEN cDNA 4930452B06 gene
chr13_-_102906046 0.611 ENSMUST00000171791.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr5_+_9100681 0.607 ENSMUST00000115365.1
Tmem243
transmembrane protein 243, mitochondrial
chr3_+_94372794 0.559 ENSMUST00000029795.3
Rorc
RAR-related orphan receptor gamma
chr9_-_100486788 0.522 ENSMUST00000098458.3
Il20rb
interleukin 20 receptor beta
chr10_+_128337761 0.486 ENSMUST00000005826.7
Cs
citrate synthase
chr14_-_52104015 0.476 ENSMUST00000111610.4
ENSMUST00000164655.1
Hnrnpc

heterogeneous nuclear ribonucleoprotein C

chrX_+_106015699 0.419 ENSMUST00000033582.4
Cox7b
cytochrome c oxidase subunit VIIb
chr5_+_138187485 0.370 ENSMUST00000110934.2
Cnpy4
canopy 4 homolog (zebrafish)
chr17_-_34000257 0.369 ENSMUST00000087189.6
ENSMUST00000173075.1
ENSMUST00000172760.1
ENSMUST00000172912.1
ENSMUST00000025181.10
H2-K1




histocompatibility 2, K1, K region




chr4_-_119294520 0.364 ENSMUST00000079644.6
Ybx1
Y box protein 1
chr4_-_140774196 0.363 ENSMUST00000026381.6
Padi4
peptidyl arginine deiminase, type IV
chr9_+_66126611 0.319 ENSMUST00000034945.5
Fam96a
family with sequence similarity 96, member A
chr3_-_116424007 0.307 ENSMUST00000090464.4
Cdc14a
CDC14 cell division cycle 14A
chr3_-_116423930 0.301 ENSMUST00000106491.2
Cdc14a
CDC14 cell division cycle 14A
chr10_+_88147061 0.295 ENSMUST00000169309.1
Nup37
nucleoporin 37
chr11_-_87108656 0.295 ENSMUST00000051395.8
Prr11
proline rich 11
chrM_+_8600 0.293 ENSMUST00000082409.1
mt-Co3
mitochondrially encoded cytochrome c oxidase III
chr17_-_48432723 0.274 ENSMUST00000046549.3
Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr19_+_5490475 0.272 ENSMUST00000116560.2
Cfl1
cofilin 1, non-muscle
chr14_+_46760526 0.255 ENSMUST00000067426.4
Cdkn3
cyclin-dependent kinase inhibitor 3
chr7_+_101896340 0.240 ENSMUST00000035395.7
ENSMUST00000106973.1
ENSMUST00000144207.1
Anapc15


anaphase prompoting complex C subunit 15


chr10_+_88146992 0.236 ENSMUST00000052355.7
Nup37
nucleoporin 37
chr5_+_138116903 0.227 ENSMUST00000062350.8
ENSMUST00000110961.2
ENSMUST00000080732.3
ENSMUST00000110960.2
ENSMUST00000142185.1
ENSMUST00000136425.1
ENSMUST00000110959.1
Zscan21






zinc finger and SCAN domain containing 21






chr14_-_59365410 0.222 ENSMUST00000161031.1
ENSMUST00000160425.1
Phf11d

PHD finger protein 11D

chr2_-_69712461 0.209 ENSMUST00000102706.3
ENSMUST00000073152.6
Fastkd1

FAST kinase domains 1

chr11_-_21371143 0.207 ENSMUST00000060895.5
Ugp2
UDP-glucose pyrophosphorylase 2
chr12_+_84417196 0.196 ENSMUST00000183146.1
Rnf113a2
ring finger protein 113A2
chr1_-_172027269 0.195 ENSMUST00000027837.6
ENSMUST00000111264.1
Vangl2

vang-like 2 (van gogh, Drosophila)

chr8_-_21906412 0.194 ENSMUST00000051965.4
Defb11
defensin beta 11
chr11_-_43747963 0.188 ENSMUST00000048578.2
ENSMUST00000109278.1
Ttc1

tetratricopeptide repeat domain 1

chr15_+_9436028 0.183 ENSMUST00000042360.3
Capsl
calcyphosine-like
chr11_+_87109221 0.179 ENSMUST00000020794.5
Ska2
spindle and kinetochore associated complex subunit 2
chr8_+_33599608 0.171 ENSMUST00000009774.9
Ppp2cb
protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
chr7_-_27195727 0.168 ENSMUST00000163311.2
ENSMUST00000126211.1
Snrpa

small nuclear ribonucleoprotein polypeptide A

chr7_+_128744870 0.167 ENSMUST00000042942.8
Sec23ip
Sec23 interacting protein
chr9_-_44113470 0.162 ENSMUST00000056328.5
Rnf26
ring finger protein 26
chr15_+_81663889 0.161 ENSMUST00000023029.8
ENSMUST00000174229.1
ENSMUST00000172748.1
L3mbtl2


l(3)mbt-like 2 (Drosophila)


chr11_+_43681998 0.155 ENSMUST00000061070.5
Pwwp2a
PWWP domain containing 2A
chr7_-_38019505 0.149 ENSMUST00000085513.4
Uri1
URI1, prefoldin-like chaperone
chr19_-_41933276 0.146 ENSMUST00000075280.4
ENSMUST00000112123.2
Exosc1

exosome component 1

chr11_-_99230998 0.142 ENSMUST00000103133.3
Smarce1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
chr9_-_20959785 0.130 ENSMUST00000177754.1
Dnmt1
DNA methyltransferase (cytosine-5) 1
chr4_-_132075250 0.118 ENSMUST00000105970.1
ENSMUST00000105975.1
Epb4.1

erythrocyte protein band 4.1

chr3_-_89101907 0.114 ENSMUST00000081848.8
Fdps
farnesyl diphosphate synthetase
chr18_+_4993795 0.113 ENSMUST00000153016.1
Svil
supervillin
chr2_-_132247747 0.112 ENSMUST00000110163.1
ENSMUST00000180286.1
ENSMUST00000028816.2
Tmem230


transmembrane protein 230


chr7_+_101896817 0.109 ENSMUST00000143835.1
Anapc15
anaphase prompoting complex C subunit 15
chr8_+_83972951 0.101 ENSMUST00000005606.6
Prkaca
protein kinase, cAMP dependent, catalytic, alpha
chr12_-_40037387 0.088 ENSMUST00000146905.1
Arl4a
ADP-ribosylation factor-like 4A
chr17_-_63863791 0.084 ENSMUST00000050753.3
A930002H24Rik
RIKEN cDNA A930002H24 gene
chr7_+_51880312 0.083 ENSMUST00000145049.1
Gas2
growth arrest specific 2
chrX_-_160138375 0.083 ENSMUST00000033662.8
Pdha1
pyruvate dehydrogenase E1 alpha 1
chr8_-_104534630 0.080 ENSMUST00000162466.1
ENSMUST00000034349.9
Nae1

NEDD8 activating enzyme E1 subunit 1

chr9_-_66126559 0.078 ENSMUST00000137542.1
Snx1
sorting nexin 1
chr7_+_29983948 0.076 ENSMUST00000148442.1
Zfp568
zinc finger protein 568
chr6_+_68161415 0.074 ENSMUST00000168090.1
Igkv1-115
immunoglobulin kappa variable 1-115
chr12_+_4769278 0.065 ENSMUST00000020967.4
Pfn4
profilin family, member 4
chr15_+_75993756 0.061 ENSMUST00000089669.4
Mapk15
mitogen-activated protein kinase 15
chr19_+_41933464 0.059 ENSMUST00000026154.7
Zdhhc16
zinc finger, DHHC domain containing 16
chr11_+_116843278 0.057 ENSMUST00000106370.3
Mettl23
methyltransferase like 23
chr1_+_190928492 0.053 ENSMUST00000066632.7
ENSMUST00000110899.1
Angel2

angel homolog 2 (Drosophila)

chr15_+_41830921 0.052 ENSMUST00000166917.1
Oxr1
oxidation resistance 1
chr5_-_137072254 0.047 ENSMUST00000077523.3
ENSMUST00000041388.4
Serpine1

serine (or cysteine) peptidase inhibitor, clade E, member 1

chrY_+_90785442 0.046 ENSMUST00000177591.1
ENSMUST00000177671.1
ENSMUST00000179077.1
Erdr1


erythroid differentiation regulator 1


chr5_-_143909782 0.041 ENSMUST00000031613.4
ENSMUST00000100483.2
Aimp2

aminoacyl tRNA synthetase complex-interacting multifunctional protein 2

chr3_-_90389884 0.040 ENSMUST00000029541.5
Slc27a3
solute carrier family 27 (fatty acid transporter), member 3
chr16_+_52031549 0.040 ENSMUST00000114471.1
Cblb
Casitas B-lineage lymphoma b
chr5_+_115605642 0.036 ENSMUST00000094427.3
Gcn1l1
GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
chr11_+_43682038 0.028 ENSMUST00000094294.4
Pwwp2a
PWWP domain containing 2A
chr12_+_4769375 0.026 ENSMUST00000178879.1
Pfn4
profilin family, member 4
chr2_+_151494182 0.024 ENSMUST00000089140.6
Nsfl1c
NSFL1 (p97) cofactor (p47)
chr7_+_24271568 0.023 ENSMUST00000032696.6
Zfp93
zinc finger protein 93
chr4_+_43493345 0.021 ENSMUST00000030181.5
ENSMUST00000107922.2
Ccdc107

coiled-coil domain containing 107

chr5_+_103425181 0.014 ENSMUST00000048957.9
Ptpn13
protein tyrosine phosphatase, non-receptor type 13
chr7_-_100964371 0.011 ENSMUST00000060174.4
P2ry6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr10_+_116301374 0.009 ENSMUST00000092167.5
Ptprb
protein tyrosine phosphatase, receptor type, B

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.3 GO:0016554 cytidine to uridine editing(GO:0016554)
0.2 1.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.2 0.5 GO:0002865 immune response-inhibiting signal transduction(GO:0002765) negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865)
0.1 0.7 GO:0007386 compartment pattern specification(GO:0007386)
0.1 0.5 GO:0090365 regulation of mRNA modification(GO:0090365)
0.1 2.1 GO:0007530 sex determination(GO:0007530)
0.1 0.4 GO:0002484 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway(GO:0002484) antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent(GO:0002485)
0.1 0.3 GO:2000812 unidimensional cell growth(GO:0009826) establishment or maintenance of cell polarity regulating cell shape(GO:0071963) regulation of barbed-end actin filament capping(GO:2000812)
0.1 1.3 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.1 0.4 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.1 0.6 GO:0072615 interleukin-17 secretion(GO:0072615)
0.1 0.2 GO:0006011 UDP-glucose metabolic process(GO:0006011) glucose 1-phosphate metabolic process(GO:0019255)
0.1 0.2 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.0 0.4 GO:0019240 citrulline biosynthetic process(GO:0019240)
0.0 0.1 GO:0071374 cellular response to parathyroid hormone stimulus(GO:0071374)
0.0 0.1 GO:0090309 positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.0 0.5 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.0 0.1 GO:0014022 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.0 0.3 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.2 GO:0043144 snoRNA processing(GO:0043144)
0.0 0.0 GO:2000097 arachidonic acid metabolite production involved in inflammatory response(GO:0002538) regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.0 0.1 GO:0016114 terpenoid biosynthetic process(GO:0016114)
0.0 0.0 GO:1903630 regulation of aminoacyl-tRNA ligase activity(GO:1903630) positive regulation of aminoacyl-tRNA ligase activity(GO:1903632)
0.0 0.0 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.0 0.2 GO:0001675 acrosome assembly(GO:0001675)
0.0 0.1 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.1 0.4 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.0 0.2 GO:0060187 cell pole(GO:0060187)
0.0 0.5 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.4 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.4 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 0.1 GO:0030905 retromer, tubulation complex(GO:0030905)
0.0 0.5 GO:0045120 pronucleus(GO:0045120)
0.0 0.2 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.7 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.3 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.1 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.1 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1 0.6 GO:0008142 oxysterol binding(GO:0008142)
0.1 0.4 GO:0034618 arginine binding(GO:0034618)
0.1 0.5 GO:0004920 interleukin-10 receptor activity(GO:0004920)
0.1 0.5 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 0.3 GO:0004126 cytidine deaminase activity(GO:0004126)
0.1 2.3 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 0.7 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.5 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.2 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.0 0.7 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.4 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.0 0.1 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.0 0.1 GO:1990460 leptin receptor binding(GO:1990460)
0.0 0.2 GO:0070569 pyrimidine ribonucleotide binding(GO:0032557) uridylyltransferase activity(GO:0070569)
0.0 0.9 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 2.3 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.0 0.1 GO:0034604 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.0 0.1 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.1 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.0 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.6 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.2 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.5 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.5 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.1 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.2 REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0 0.3 REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION Genes involved in Sema3A PAK dependent Axon repulsion