Motif ID: Hoxb5

Z-value: 1.061


Transcription factors associated with Hoxb5:

Gene SymbolEntrez IDGene Name
Hoxb5 ENSMUSG00000038700.3 Hoxb5



Activity profile for motif Hoxb5.

activity profile for motif Hoxb5


Sorted Z-values histogram for motif Hoxb5

Sorted Z-values for motif Hoxb5



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb5

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_125532377 7.865 ENSMUST00000031446.6
Tmem132b
transmembrane protein 132B
chr6_-_18514802 4.737 ENSMUST00000090601.5
Cttnbp2
cortactin binding protein 2
chr17_-_57087729 4.061 ENSMUST00000071135.5
Tubb4a
tubulin, beta 4A class IVA
chr1_-_56971762 3.410 ENSMUST00000114415.3
Satb2
special AT-rich sequence binding protein 2
chr11_+_74619594 2.713 ENSMUST00000100866.2
E130309D14Rik
RIKEN cDNA E130309D14 gene
chr3_-_85722474 2.434 ENSMUST00000119077.1
Fam160a1
family with sequence similarity 160, member A1
chr2_+_158667119 2.390 ENSMUST00000045503.4
Ppp1r16b
protein phosphatase 1, regulatory (inhibitor) subunit 16B
chr17_+_35077080 2.221 ENSMUST00000172959.1
Ly6g6e
lymphocyte antigen 6 complex, locus G6E
chr12_-_78980758 2.150 ENSMUST00000174072.1
Tmem229b
transmembrane protein 229B
chr17_+_35076902 2.017 ENSMUST00000172494.1
ENSMUST00000172678.1
ENSMUST00000013910.4
Ly6g6e


lymphocyte antigen 6 complex, locus G6E


chr6_+_121636173 1.982 ENSMUST00000032203.7
A2m
alpha-2-macroglobulin
chr12_-_78983476 1.915 ENSMUST00000070174.7
Tmem229b
transmembrane protein 229B
chr19_-_45816007 1.911 ENSMUST00000079431.3
ENSMUST00000026247.6
ENSMUST00000162528.2
Kcnip2


Kv channel-interacting protein 2


chr5_+_117133567 1.813 ENSMUST00000179276.1
ENSMUST00000092889.5
ENSMUST00000145640.1
Taok3


TAO kinase 3


chr2_-_153225396 1.586 ENSMUST00000099194.2
Tspyl3
TSPY-like 3
chr13_+_88821472 1.516 ENSMUST00000118731.1
ENSMUST00000081769.6
Edil3

EGF-like repeats and discoidin I-like domains 3

chrX_-_165327376 1.477 ENSMUST00000058787.8
Glra2
glycine receptor, alpha 2 subunit
chr7_-_123500449 1.370 ENSMUST00000042470.7
ENSMUST00000128217.1
Zkscan2

zinc finger with KRAB and SCAN domains 2

chr13_+_88821606 1.356 ENSMUST00000043111.6
Edil3
EGF-like repeats and discoidin I-like domains 3
chr10_-_81014902 1.263 ENSMUST00000126317.1
ENSMUST00000092285.3
ENSMUST00000117805.1
Gng7


guanine nucleotide binding protein (G protein), gamma 7


chr3_-_89160155 1.209 ENSMUST00000029686.3
Hcn3
hyperpolarization-activated, cyclic nucleotide-gated K+ 3
chr9_+_20581296 1.190 ENSMUST00000115557.2
Zfp846
zinc finger protein 846
chr11_+_97798995 1.089 ENSMUST00000143571.1
Lasp1
LIM and SH3 protein 1
chr15_-_28025834 1.038 ENSMUST00000090247.5
Trio
triple functional domain (PTPRF interacting)
chr1_-_193370260 1.025 ENSMUST00000016323.4
Camk1g
calcium/calmodulin-dependent protein kinase I gamma
chr1_-_193370225 1.015 ENSMUST00000169907.1
Camk1g
calcium/calmodulin-dependent protein kinase I gamma
chr5_-_103211251 1.002 ENSMUST00000060871.5
ENSMUST00000112846.1
ENSMUST00000170792.1
ENSMUST00000112847.2
Mapk10



mitogen-activated protein kinase 10



chr7_-_109083284 0.985 ENSMUST00000120876.1
ENSMUST00000055993.6
Ric3

resistance to inhibitors of cholinesterase 3 homolog (C. elegans)

chr13_+_14063776 0.919 ENSMUST00000129488.1
ENSMUST00000110536.1
ENSMUST00000110534.1
ENSMUST00000039538.8
ENSMUST00000110533.1
Arid4b




AT rich interactive domain 4B (RBP1-like)




chr2_-_167062607 0.919 ENSMUST00000128676.1
Znfx1
zinc finger, NFX1-type containing 1
chr14_+_32159865 0.867 ENSMUST00000163336.1
ENSMUST00000169722.1
ENSMUST00000168385.1
Ncoa4


nuclear receptor coactivator 4


chr10_+_80300997 0.865 ENSMUST00000140828.1
ENSMUST00000138909.1
Apc2

adenomatosis polyposis coli 2

chrX_+_7822289 0.851 ENSMUST00000009875.4
Kcnd1
potassium voltage-gated channel, Shal-related family, member 1
chr7_+_3390629 0.851 ENSMUST00000182222.1
Cacng8
calcium channel, voltage-dependent, gamma subunit 8
chr6_+_141249161 0.837 ENSMUST00000043259.7
Pde3a
phosphodiesterase 3A, cGMP inhibited
chr12_+_17924294 0.791 ENSMUST00000169657.1
B430203G13Rik
RIKEN cDNA B430203G13 gene
chr8_+_95081187 0.737 ENSMUST00000034239.7
Katnb1
katanin p80 (WD40-containing) subunit B 1
chr17_+_31386218 0.720 ENSMUST00000047168.5
Pde9a
phosphodiesterase 9A
chr10_+_21882184 0.715 ENSMUST00000120509.1
Sgk1
serum/glucocorticoid regulated kinase 1
chr17_+_94873986 0.693 ENSMUST00000108007.4
Gm20939
predicted gene, 20939
chr7_+_119895836 0.677 ENSMUST00000106518.1
ENSMUST00000054440.3
Lyrm1

LYR motif containing 1

chr17_+_31386244 0.676 ENSMUST00000134525.1
ENSMUST00000127929.1
Pde9a

phosphodiesterase 9A

chr5_+_143933059 0.672 ENSMUST00000166847.1
Rsph10b
radial spoke head 10 homolog B (Chlamydomonas)
chr8_-_25597459 0.666 ENSMUST00000079160.6
Letm2
leucine zipper-EF-hand containing transmembrane protein 2
chrX_+_7723278 0.656 ENSMUST00000144148.1
Wdr45
WD repeat domain 45
chr14_-_41004517 0.655 ENSMUST00000153830.1
Fam213a
family with sequence similarity 213, member A
chr14_+_55560010 0.635 ENSMUST00000147981.1
ENSMUST00000133256.1
Dcaf11

DDB1 and CUL4 associated factor 11

chr7_+_119896292 0.598 ENSMUST00000106517.1
Lyrm1
LYR motif containing 1
chr14_-_63543931 0.570 ENSMUST00000058679.5
Mtmr9
myotubularin related protein 9
chr7_-_119895697 0.541 ENSMUST00000059851.6
Dcun1d3
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr16_+_17070127 0.496 ENSMUST00000115729.1
Ypel1
yippee-like 1 (Drosophila)
chr2_+_85136355 0.492 ENSMUST00000057019.7
Aplnr
apelin receptor
chr8_-_85840877 0.485 ENSMUST00000034140.7
Itfg1
integrin alpha FG-GAP repeat containing 1
chr11_-_69197809 0.482 ENSMUST00000094078.3
ENSMUST00000021262.3
Alox8

arachidonate 8-lipoxygenase

chr10_-_88683021 0.452 ENSMUST00000004473.8
Spic
Spi-C transcription factor (Spi-1/PU.1 related)
chr7_-_133708958 0.446 ENSMUST00000106146.1
Uros
uroporphyrinogen III synthase
chr7_-_100964371 0.431 ENSMUST00000060174.4
P2ry6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr4_+_11704439 0.421 ENSMUST00000108304.2
Gem
GTP binding protein (gene overexpressed in skeletal muscle)
chr9_-_35116804 0.412 ENSMUST00000034537.6
St3gal4
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
chr7_-_133709069 0.404 ENSMUST00000106145.3
Uros
uroporphyrinogen III synthase
chr6_-_113501818 0.378 ENSMUST00000101059.1
Prrt3
proline-rich transmembrane protein 3
chr10_-_127211528 0.373 ENSMUST00000013970.7
Pip4k2c
phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
chr14_+_55559993 0.370 ENSMUST00000117236.1
Dcaf11
DDB1 and CUL4 associated factor 11
chr1_-_166409773 0.363 ENSMUST00000135673.1
ENSMUST00000079972.6
ENSMUST00000169324.1
ENSMUST00000111411.2
ENSMUST00000128861.1
Pogk




pogo transposable element with KRAB domain




chr5_-_114273702 0.342 ENSMUST00000144050.1
ENSMUST00000044790.5
Foxn4

forkhead box N4

chr11_-_96075655 0.338 ENSMUST00000090541.5
Atp5g1
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c1 (subunit 9)
chr6_+_86438360 0.336 ENSMUST00000050497.7
C87436
expressed sequence C87436
chr4_-_52497244 0.319 ENSMUST00000114578.4
Vma21-ps
VMA21 vacuolar H+-ATPase homolog (S. cerevisiae), pseudogene
chr12_+_116275386 0.307 ENSMUST00000090195.4
Gm11027
predicted gene 11027
chr7_-_31150981 0.296 ENSMUST00000085636.6
ENSMUST00000001280.7
Gramd1a

GRAM domain containing 1A

chr7_+_19004047 0.269 ENSMUST00000053713.3
Irf2bp1
interferon regulatory factor 2 binding protein 1
chr7_-_133709051 0.269 ENSMUST00000124759.1
ENSMUST00000106144.1
Uros

uroporphyrinogen III synthase

chr16_+_17070220 0.265 ENSMUST00000141959.1
Ypel1
yippee-like 1 (Drosophila)
chr8_+_123332676 0.259 ENSMUST00000010298.6
Spire2
spire homolog 2 (Drosophila)
chr11_+_4873951 0.249 ENSMUST00000038570.2
Nipsnap1
4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (C. elegans)
chr3_+_89215170 0.247 ENSMUST00000029682.4
Thbs3
thrombospondin 3
chr2_-_116065798 0.247 ENSMUST00000110907.1
ENSMUST00000110908.2
Meis2

Meis homeobox 2

chr3_-_103737995 0.240 ENSMUST00000029440.8
Olfml3
olfactomedin-like 3
chr2_+_116067933 0.239 ENSMUST00000156095.1
G630016G05Rik
RIKEN cDNA G630016G05 gene
chr7_-_119896285 0.236 ENSMUST00000106519.1
Dcun1d3
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr9_-_35558522 0.229 ENSMUST00000034612.5
Ddx25
DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
chr10_-_62143906 0.210 ENSMUST00000141724.1
ENSMUST00000150057.1
2010107G23Rik

RIKEN cDNA 2010107G23 gene

chr13_+_93304066 0.168 ENSMUST00000109493.1
Homer1
homer homolog 1 (Drosophila)
chr1_+_74544345 0.156 ENSMUST00000027362.7
Plcd4
phospholipase C, delta 4
chr7_+_16875302 0.129 ENSMUST00000108493.1
Dact3
dapper homolog 3, antagonist of beta-catenin (xenopus)
chr15_+_12205009 0.079 ENSMUST00000038172.8
Mtmr12
myotubularin related protein 12
chrX_+_151046131 0.067 ENSMUST00000112685.1
Fgd1
FYVE, RhoGEF and PH domain containing 1
chr2_+_26973416 0.066 ENSMUST00000014996.7
ENSMUST00000102891.3
Adamts13

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13

chr10_-_63927434 0.055 ENSMUST00000079279.3
Gm10118
predicted gene 10118
chr17_+_57105385 0.039 ENSMUST00000039490.7
Tnfsf9
tumor necrosis factor (ligand) superfamily, member 9
chr8_+_70594466 0.028 ENSMUST00000019283.9
Isyna1
myo-inositol 1-phosphate synthase A1
chr13_-_14063395 0.016 ENSMUST00000170957.1
Ggps1
geranylgeranyl diphosphate synthase 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.5 2.4 GO:1903587 negative regulation of peptidyl-serine dephosphorylation(GO:1902309) regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587)
0.4 1.9 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.3 1.1 GO:0006780 uroporphyrinogen III biosynthetic process(GO:0006780)
0.2 1.5 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.2 0.7 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.2 4.8 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.2 3.4 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.2 0.8 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.2 1.0 GO:0007258 JUN phosphorylation(GO:0007258)
0.2 0.5 GO:0002030 inhibitory G-protein coupled receptor phosphorylation(GO:0002030)
0.2 4.2 GO:0022401 desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) negative adaptation of signaling pathway(GO:0022401)
0.2 0.9 GO:0034773 histone H4-K20 trimethylation(GO:0034773) establishment of Sertoli cell barrier(GO:0097368)
0.1 0.4 GO:0030321 transepithelial chloride transport(GO:0030321)
0.1 1.3 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1 0.5 GO:0019372 lipoxygenase pathway(GO:0019372)
0.1 0.3 GO:0070649 formin-nucleated actin cable assembly(GO:0070649)
0.1 1.8 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.1 1.4 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 1.0 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.0 0.7 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.0 0.4 GO:1901386 negative regulation of voltage-gated calcium channel activity(GO:1901386)
0.0 0.8 GO:0010225 response to UV-C(GO:0010225)
0.0 0.9 GO:0006622 protein targeting to lysosome(GO:0006622)
0.0 1.0 GO:0007271 synaptic transmission, cholinergic(GO:0007271)
0.0 0.4 GO:2000786 positive regulation of autophagosome assembly(GO:2000786)
0.0 0.9 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0 0.3 GO:0035881 amacrine cell differentiation(GO:0035881)
0.0 0.2 GO:0060346 bone trabecula formation(GO:0060346)
0.0 2.9 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 1.2 GO:0035725 sodium ion transmembrane transport(GO:0035725)
0.0 0.2 GO:0048875 chemical homeostasis within a tissue(GO:0048875)
0.0 2.0 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.0 0.3 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.0 0.7 GO:0045670 regulation of osteoclast differentiation(GO:0045670)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.1 GO:0033269 internode region of axon(GO:0033269)
0.2 1.2 GO:0044316 cone cell pedicle(GO:0044316)
0.1 0.9 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 0.9 GO:0044754 autolysosome(GO:0044754)
0.0 0.7 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 3.4 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 1.2 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.2 GO:0033391 chromatoid body(GO:0033391)
0.0 2.8 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 1.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 1.0 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.9 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 2.0 GO:0072562 blood microparticle(GO:0072562)
0.0 4.2 GO:0008021 synaptic vesicle(GO:0008021)
0.0 2.4 GO:0043204 perikaryon(GO:0043204)
0.0 2.4 GO:0030496 midbody(GO:0030496)
0.0 1.1 GO:0030864 cortical actin cytoskeleton(GO:0030864)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.2 GO:0030549 acetylcholine receptor activator activity(GO:0030549)
0.7 2.0 GO:0019966 C-X-C chemokine binding(GO:0019958) interleukin-1 binding(GO:0019966) tumor necrosis factor binding(GO:0043120)
0.6 4.7 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.6 2.8 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.5 1.5 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.3 1.2 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.3 1.0 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.2 1.1 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.1 0.4 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.1 0.7 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 0.4 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1 0.7 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.1 1.8 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 1.4 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.1 0.4 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 2.0 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 4.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.5 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0 1.0 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.0 0.8 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.8 GO:0097602 cullin family protein binding(GO:0097602)
0.0 2.4 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 2.9 GO:0005178 integrin binding(GO:0005178)
0.0 0.7 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.3 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.2 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 0.1 GO:0070097 delta-catenin binding(GO:0070097)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.9 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 2.0 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 1.0 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 1.0 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.7 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 1.4 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 0.7 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.0 0.9 PID_TELOMERASE_PATHWAY Regulation of Telomerase

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.1 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.2 2.0 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.1 2.2 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 1.2 REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT Genes involved in Ligand-gated ion channel transport
0.1 1.1 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.4 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 1.0 REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 1.3 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 1.0 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.0 2.1 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.0 0.9 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 0.3 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling