Motif ID: Nkx2-4

Z-value: 0.532


Transcription factors associated with Nkx2-4:

Gene SymbolEntrez IDGene Name
Nkx2-4 ENSMUSG00000054160.2 Nkx2-4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-4mm10_v2_chr2_-_147085445_1470854830.155.4e-01Click!


Activity profile for motif Nkx2-4.

activity profile for motif Nkx2-4


Sorted Z-values histogram for motif Nkx2-4

Sorted Z-values for motif Nkx2-4



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_4611971 1.614 ENSMUST00000105590.1
ENSMUST00000067086.7
Esr1

estrogen receptor 1 (alpha)

chr13_-_66852017 1.412 ENSMUST00000059329.6
Gm17449
predicted gene, 17449
chr13_+_65512678 1.268 ENSMUST00000081471.2
Gm10139
predicted gene 10139
chr1_+_178798438 0.918 ENSMUST00000160789.1
Kif26b
kinesin family member 26B
chr15_-_26895049 0.745 ENSMUST00000059204.9
Fbxl7
F-box and leucine-rich repeat protein 7
chr7_-_115824699 0.731 ENSMUST00000169129.1
Sox6
SRY-box containing gene 6
chr15_+_99055164 0.716 ENSMUST00000047104.7
ENSMUST00000024249.3
Prph

peripherin

chr12_-_91746020 0.612 ENSMUST00000166967.1
Ston2
stonin 2
chr14_+_48446128 0.605 ENSMUST00000124720.1
Tmem260
transmembrane protein 260
chr8_+_45628176 0.588 ENSMUST00000130850.1
Sorbs2
sorbin and SH3 domain containing 2
chr2_-_27507656 0.575 ENSMUST00000154316.1
Brd3
bromodomain containing 3
chr3_+_88629499 0.550 ENSMUST00000175745.1
Arhgef2
rho/rac guanine nucleotide exchange factor (GEF) 2
chr6_+_30568367 0.540 ENSMUST00000049251.5
Cpa4
carboxypeptidase A4
chr13_+_108316395 0.539 ENSMUST00000171178.1
Depdc1b
DEP domain containing 1B
chr11_+_98863610 0.525 ENSMUST00000142414.1
ENSMUST00000037480.8
Wipf2

WAS/WASL interacting protein family, member 2

chr5_+_32136458 0.495 ENSMUST00000031017.9
Fosl2
fos-like antigen 2
chr8_+_45627946 0.460 ENSMUST00000145458.1
Sorbs2
sorbin and SH3 domain containing 2
chr7_-_132813095 0.455 ENSMUST00000106165.1
Fam53b
family with sequence similarity 53, member B
chr2_-_93046053 0.434 ENSMUST00000111272.1
ENSMUST00000178666.1
ENSMUST00000147339.1
Prdm11


PR domain containing 11


chr2_+_25180737 0.431 ENSMUST00000104999.2
Nrarp
Notch-regulated ankyrin repeat protein
chr7_-_100932140 0.416 ENSMUST00000107032.1
Arhgef17
Rho guanine nucleotide exchange factor (GEF) 17
chr3_+_52268337 0.415 ENSMUST00000053764.5
Foxo1
forkhead box O1
chr8_+_66860215 0.398 ENSMUST00000118009.1
Naf1
nuclear assembly factor 1 homolog (S. cerevisiae)
chr9_-_71896047 0.368 ENSMUST00000184448.1
Tcf12
transcription factor 12
chr11_+_101733011 0.367 ENSMUST00000129741.1
Dhx8
DEAH (Asp-Glu-Ala-His) box polypeptide 8
chr11_+_101732950 0.348 ENSMUST00000039152.7
Dhx8
DEAH (Asp-Glu-Ala-His) box polypeptide 8
chr11_+_87592897 0.344 ENSMUST00000119628.1
Mtmr4
myotubularin related protein 4
chr10_+_128232065 0.327 ENSMUST00000055539.4
ENSMUST00000105244.1
ENSMUST00000105243.2
ENSMUST00000125289.1
ENSMUST00000105242.1
Timeless




timeless circadian clock 1




chr14_-_47418407 0.311 ENSMUST00000043296.3
Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr12_-_105685235 0.310 ENSMUST00000041055.7
Atg2b
autophagy related 2B
chr11_-_102579461 0.302 ENSMUST00000107081.1
Gm11627
predicted gene 11627
chr1_+_97024681 0.290 ENSMUST00000054664.7
Gm6430
predicted gene 6430
chr12_+_38781093 0.278 ENSMUST00000161513.1
Etv1
ets variant gene 1
chr14_+_26514554 0.263 ENSMUST00000104927.1
Gm2178
predicted gene 2178
chr4_+_62525369 0.260 ENSMUST00000062145.1
4933430I17Rik
RIKEN cDNA 4933430I17 gene
chr2_+_157456917 0.237 ENSMUST00000109529.1
Src
Rous sarcoma oncogene
chrX_-_143933089 0.236 ENSMUST00000087313.3
Dcx
doublecortin
chr6_+_29398920 0.233 ENSMUST00000181464.1
ENSMUST00000180829.1
Ccdc136

coiled-coil domain containing 136

chr8_-_40308331 0.233 ENSMUST00000118639.1
Fgf20
fibroblast growth factor 20
chr11_-_103697661 0.226 ENSMUST00000107013.2
Gosr2
golgi SNAP receptor complex member 2
chr2_+_156840966 0.220 ENSMUST00000109564.1
Tgif2
TGFB-induced factor homeobox 2
chr8_+_46490968 0.219 ENSMUST00000110372.1
ENSMUST00000130563.1
Acsl1

acyl-CoA synthetase long-chain family member 1

chr10_+_20347788 0.198 ENSMUST00000169712.1
Mtfr2
mitochondrial fission regulator 2
chr2_+_30061754 0.196 ENSMUST00000149578.1
ENSMUST00000102866.3
Set

SET nuclear oncogene

chr9_+_108560422 0.191 ENSMUST00000081111.8
Impdh2
inosine 5'-phosphate dehydrogenase 2
chr1_+_34439851 0.186 ENSMUST00000027303.7
Imp4
IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast)
chr1_-_118311132 0.171 ENSMUST00000027623.7
Tsn
translin
chr2_+_61804453 0.164 ENSMUST00000048934.8
Tbr1
T-box brain gene 1
chr3_+_121291725 0.163 ENSMUST00000039442.7
Alg14
asparagine-linked glycosylation 14
chr6_+_94500313 0.163 ENSMUST00000061118.8
Slc25a26
solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26
chr13_-_105271039 0.159 ENSMUST00000069686.6
Rnf180
ring finger protein 180
chr3_+_96696379 0.138 ENSMUST00000107076.3
Pias3
protein inhibitor of activated STAT 3
chr17_-_25844417 0.135 ENSMUST00000176591.1
Rhot2
ras homolog gene family, member T2
chr6_-_29165003 0.134 ENSMUST00000007993.9
Rbm28
RNA binding motif protein 28
chr2_-_34755229 0.134 ENSMUST00000102800.1
Gapvd1
GTPase activating protein and VPS9 domains 1
chr9_-_52679429 0.128 ENSMUST00000098768.2
AI593442
expressed sequence AI593442
chr5_+_34999111 0.114 ENSMUST00000114283.1
Rgs12
regulator of G-protein signaling 12
chr2_+_169632996 0.110 ENSMUST00000109159.2
Tshz2
teashirt zinc finger family member 2
chr1_-_34439672 0.100 ENSMUST00000042493.8
Ccdc115
coiled-coil domain containing 115
chr8_-_31739763 0.099 ENSMUST00000178878.1
Gm5117
predicted gene 5117
chr12_+_88360801 0.097 ENSMUST00000166940.1
Adck1
aarF domain containing kinase 1
chr10_+_88091070 0.096 ENSMUST00000048621.7
Pmch
pro-melanin-concentrating hormone
chr4_-_136892867 0.096 ENSMUST00000046332.5
C1qc
complement component 1, q subcomponent, C chain
chr3_-_59220150 0.089 ENSMUST00000170388.1
P2ry12
purinergic receptor P2Y, G-protein coupled 12
chr8_+_45627709 0.088 ENSMUST00000134321.1
ENSMUST00000135336.1
Sorbs2

sorbin and SH3 domain containing 2

chr19_-_6969746 0.084 ENSMUST00000025912.8
Plcb3
phospholipase C, beta 3
chr12_+_38780817 0.080 ENSMUST00000160856.1
Etv1
ets variant gene 1
chr8_+_77549393 0.073 ENSMUST00000056237.8
ENSMUST00000118622.1
Prmt10

protein arginine methyltransferase 10 (putative)

chr3_-_110250963 0.068 ENSMUST00000106567.1
Prmt6
protein arginine N-methyltransferase 6
chr10_+_42502197 0.059 ENSMUST00000105499.1
Snx3
sorting nexin 3
chr6_+_123229843 0.044 ENSMUST00000112554.2
ENSMUST00000024118.4
ENSMUST00000117130.1
Clec4n


C-type lectin domain family 4, member n


chr17_+_84956718 0.039 ENSMUST00000112305.3
Ppm1b
protein phosphatase 1B, magnesium dependent, beta isoform
chr6_+_96113146 0.039 ENSMUST00000122120.1
Fam19a1
family with sequence similarity 19, member A1
chr7_-_44670820 0.035 ENSMUST00000048102.7
Myh14
myosin, heavy polypeptide 14
chr12_+_69963452 0.034 ENSMUST00000110560.1
Gm3086
predicted gene 3086
chr11_+_49247462 0.033 ENSMUST00000109194.1
Mgat1
mannoside acetylglucosaminyltransferase 1
chr5_+_24685815 0.029 ENSMUST00000068825.6
Nub1
negative regulator of ubiquitin-like proteins 1
chr5_-_137533297 0.027 ENSMUST00000111020.1
ENSMUST00000111023.1
Gnb2

guanine nucleotide binding protein (G protein), beta 2

chr2_+_169633517 0.019 ENSMUST00000109157.1
Tshz2
teashirt zinc finger family member 2
chr14_+_55672235 0.013 ENSMUST00000002397.5
Gmpr2
guanosine monophosphate reductase 2
chr10_-_26373956 0.002 ENSMUST00000105519.3
ENSMUST00000040219.6
L3mbtl3

l(3)mbt-like 3 (Drosophila)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.6 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.3 0.9 GO:0072092 ureteric bud invasion(GO:0072092)
0.1 0.3 GO:1904975 response to bleomycin(GO:1904975) cellular response to bleomycin(GO:1904976)
0.1 0.4 GO:0090669 snoRNA guided rRNA pseudouridine synthesis(GO:0000454) telomerase RNA stabilization(GO:0090669)
0.1 0.6 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.1 0.7 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.1 0.2 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180)
0.0 0.1 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747)
0.0 0.4 GO:0014807 regulation of somitogenesis(GO:0014807)
0.0 0.2 GO:0006177 GMP biosynthetic process(GO:0006177)
0.0 0.4 GO:0071455 cellular response to hyperoxia(GO:0071455)
0.0 0.2 GO:0001661 conditioned taste aversion(GO:0001661) amygdala development(GO:0021764)
0.0 0.2 GO:0051182 coenzyme transport(GO:0051182)
0.0 0.4 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 0.1 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.0 0.5 GO:0003334 keratinocyte development(GO:0003334)
0.0 1.1 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.1 GO:0038032 termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.0 0.1 GO:0031161 phosphatidylinositol catabolic process(GO:0031161)
0.0 0.7 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.1 GO:2000642 negative regulation of early endosome to late endosome transport(GO:2000642)
0.0 0.2 GO:0001675 acrosome assembly(GO:0001675)
0.0 0.7 GO:0045104 intermediate filament cytoskeleton organization(GO:0045104)
0.0 0.2 GO:0044539 long-chain fatty acid import(GO:0044539)
0.0 0.2 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 0.1 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.0 0.3 GO:0044804 nucleophagy(GO:0044804)
0.0 0.2 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 0.1 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
0.0 0.1 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.0 0.2 GO:0038092 nodal signaling pathway(GO:0038092)
0.0 0.6 GO:0048488 synaptic vesicle endocytosis(GO:0048488)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0044299 C-fiber(GO:0044299)
0.2 1.6 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.1 0.2 GO:0034457 Mpp10 complex(GO:0034457)
0.0 0.4 GO:0005732 small nucleolar ribonucleoprotein complex(GO:0005732)
0.0 0.1 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 0.3 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.9 GO:0005871 kinesin complex(GO:0005871)
0.0 0.2 GO:0002080 acrosomal membrane(GO:0002080)
0.0 0.2 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.1 0.2 GO:0043758 acetate-CoA ligase (ADP-forming) activity(GO:0043758)
0.1 0.2 GO:0030519 snoRNP binding(GO:0030519)
0.0 0.2 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.0 0.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.2 GO:0051185 coenzyme transporter activity(GO:0051185)
0.0 0.2 GO:0071253 connexin binding(GO:0071253)
0.0 0.6 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.4 GO:0070034 telomerase RNA binding(GO:0070034)
0.0 0.4 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.6 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.1 GO:0044020 protein-arginine omega-N monomethyltransferase activity(GO:0035241) histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.0 0.4 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.1 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.9 GO:0003777 microtubule motor activity(GO:0003777)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.9 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling
0.0 0.3 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.5 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.4 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 1.0 PID_RHOA_REG_PATHWAY Regulation of RhoA activity

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.6 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 0.3 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.2 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 0.1 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.2 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 1.0 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 0.1 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.2 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism