Motif ID: Hoxc13_Hoxd13

Z-value: 1.018







Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxc13_Hoxd13

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_54945038 6.102 ENSMUST00000133895.1
Zfp462
zinc finger protein 462
chr10_-_8518801 5.740 ENSMUST00000061601.7
Ust
uronyl-2-sulfotransferase
chr1_-_56978534 5.559 ENSMUST00000177282.1
Satb2
special AT-rich sequence binding protein 2
chr6_+_108213086 5.501 ENSMUST00000032192.6
Itpr1
inositol 1,4,5-trisphosphate receptor 1
chr17_-_6477102 4.463 ENSMUST00000167717.2
Tmem181b-ps
transmembrane protein 181B, pseudogene
chr17_+_6270475 4.122 ENSMUST00000088940.4
Tmem181a
transmembrane protein 181A
chr16_-_74411776 3.559 ENSMUST00000116586.2
Robo2
roundabout homolog 2 (Drosophila)
chr7_-_73537621 3.334 ENSMUST00000172704.1
Chd2
chromodomain helicase DNA binding protein 2
chr17_+_75178911 2.579 ENSMUST00000112514.1
Ltbp1
latent transforming growth factor beta binding protein 1
chr11_+_77216180 2.482 ENSMUST00000037912.5
ENSMUST00000156488.1
Ssh2

slingshot homolog 2 (Drosophila)

chr19_-_7341848 2.431 ENSMUST00000171393.1
Mark2
MAP/microtubule affinity-regulating kinase 2
chr17_+_75178797 2.409 ENSMUST00000112516.1
ENSMUST00000135447.1
Ltbp1

latent transforming growth factor beta binding protein 1

chr16_+_23226014 2.175 ENSMUST00000178797.1
St6gal1
beta galactoside alpha 2,6 sialyltransferase 1
chr18_+_69346143 2.110 ENSMUST00000114980.1
Tcf4
transcription factor 4
chr5_+_17574268 1.809 ENSMUST00000030568.7
Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chrX_-_7319291 1.395 ENSMUST00000128319.1
Clcn5
chloride channel 5
chrX_-_7319186 1.310 ENSMUST00000115746.1
Clcn5
chloride channel 5
chr9_-_96719404 1.302 ENSMUST00000140121.1
Zbtb38
zinc finger and BTB domain containing 38
chr3_-_142169196 1.290 ENSMUST00000098568.1
Bmpr1b
bone morphogenetic protein receptor, type 1B
chr6_+_71909046 1.280 ENSMUST00000055296.8
Polr1a
polymerase (RNA) I polypeptide A
chr9_+_32696005 1.216 ENSMUST00000034534.6
ENSMUST00000050797.7
ENSMUST00000184887.1
Ets1


E26 avian leukemia oncogene 1, 5' domain


chr1_-_74124420 1.142 ENSMUST00000169786.1
Tns1
tensin 1
chr6_-_112947246 1.121 ENSMUST00000088373.4
Srgap3
SLIT-ROBO Rho GTPase activating protein 3
chr3_-_142169311 1.062 ENSMUST00000106230.1
Bmpr1b
bone morphogenetic protein receptor, type 1B
chr2_+_112265809 1.020 ENSMUST00000110991.2
Slc12a6
solute carrier family 12, member 6
chr9_-_96719549 0.977 ENSMUST00000128269.1
Zbtb38
zinc finger and BTB domain containing 38
chr3_+_59006978 0.919 ENSMUST00000040325.7
ENSMUST00000164225.1
ENSMUST00000040846.8
ENSMUST00000029393.8
Med12l



mediator of RNA polymerase II transcription, subunit 12 homolog (yeast)-like



chr16_-_57231434 0.898 ENSMUST00000023431.6
Tbc1d23
TBC1 domain family, member 23
chr18_-_38209762 0.894 ENSMUST00000057185.6
Pcdh1
protocadherin 1
chr10_-_120979327 0.865 ENSMUST00000119944.1
ENSMUST00000119093.1
Lemd3

LEM domain containing 3

chr3_+_126597415 0.854 ENSMUST00000066452.7
ENSMUST00000171289.1
ENSMUST00000106399.1
Camk2d


calcium/calmodulin-dependent protein kinase II, delta


chr12_-_34528844 0.841 ENSMUST00000110819.2
Hdac9
histone deacetylase 9
chr2_-_170427828 0.811 ENSMUST00000013667.2
ENSMUST00000109152.2
ENSMUST00000068137.4
Bcas1


breast carcinoma amplified sequence 1


chr13_+_16014457 0.810 ENSMUST00000164993.1
Inhba
inhibin beta-A
chr4_-_82850721 0.785 ENSMUST00000139401.1
Zdhhc21
zinc finger, DHHC domain containing 21
chr4_-_110290884 0.771 ENSMUST00000142722.1
Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr10_-_128696257 0.728 ENSMUST00000000727.2
Rab5b
RAB5B, member RAS oncogene family
chr17_+_43568641 0.691 ENSMUST00000169694.1
Pla2g7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr17_+_43568475 0.679 ENSMUST00000167418.1
Pla2g7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr8_+_83666827 0.643 ENSMUST00000019608.5
Ptger1
prostaglandin E receptor 1 (subtype EP1)
chr18_+_37484955 0.583 ENSMUST00000053856.4
Pcdhb17
protocadherin beta 17
chr14_-_103346765 0.572 ENSMUST00000159855.1
Mycbp2
MYC binding protein 2
chr5_-_121836810 0.547 ENSMUST00000118580.1
ENSMUST00000040308.7
Sh2b3

SH2B adaptor protein 3

chr18_+_37355271 0.545 ENSMUST00000051163.1
Pcdhb8
protocadherin beta 8
chr2_-_66440753 0.518 ENSMUST00000112371.2
ENSMUST00000138910.1
Scn1a

sodium channel, voltage-gated, type I, alpha

chr17_+_43568269 0.515 ENSMUST00000024706.5
Pla2g7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr1_-_36273425 0.496 ENSMUST00000056946.6
Neurl3
neuralized homolog 3 homolog (Drosophila)
chr5_-_62766153 0.461 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr3_+_126597299 0.453 ENSMUST00000106400.2
ENSMUST00000106401.1
Camk2d

calcium/calmodulin-dependent protein kinase II, delta

chr5_-_66514815 0.445 ENSMUST00000161879.1
ENSMUST00000159357.1
Apbb2

amyloid beta (A4) precursor protein-binding, family B, member 2

chr14_-_76110760 0.389 ENSMUST00000022585.3
Gpalpp1
GPALPP motifs containing 1
chr8_-_70139197 0.379 ENSMUST00000075724.7
Rfxank
regulatory factor X-associated ankyrin-containing protein
chr14_+_32321987 0.313 ENSMUST00000022480.7
Ogdhl
oxoglutarate dehydrogenase-like
chr9_-_77347816 0.297 ENSMUST00000184138.1
ENSMUST00000184006.1
ENSMUST00000185144.1
ENSMUST00000034910.9
Mlip



muscular LMNA-interacting protein



chr11_-_5381734 0.290 ENSMUST00000172492.1
Znrf3
zinc and ring finger 3
chr18_-_46280820 0.288 ENSMUST00000025354.3
Pggt1b
protein geranylgeranyltransferase type I, beta subunit
chr11_-_5542177 0.267 ENSMUST00000020776.4
Ccdc117
coiled-coil domain containing 117
chr8_+_56551090 0.266 ENSMUST00000040218.5
ENSMUST00000110322.3
Fbxo8

F-box protein 8

chr1_-_45503282 0.261 ENSMUST00000086430.4
Col5a2
collagen, type V, alpha 2
chr17_-_51826562 0.242 ENSMUST00000024720.4
ENSMUST00000129667.1
ENSMUST00000156051.1
ENSMUST00000169480.1
ENSMUST00000148559.1
Satb1




special AT-rich sequence binding protein 1




chr2_-_180824596 0.236 ENSMUST00000148700.1
Gm14340
predicted gene 14340
chr17_+_46650328 0.234 ENSMUST00000043464.7
Cul7
cullin 7
chr12_-_48559971 0.224 ENSMUST00000169406.1
Gm1818
predicted gene 1818
chr9_-_77347787 0.221 ENSMUST00000184848.1
ENSMUST00000184415.1
Mlip

muscular LMNA-interacting protein

chr3_+_95658771 0.209 ENSMUST00000178686.1
Mcl1
myeloid cell leukemia sequence 1
chr9_+_50575273 0.169 ENSMUST00000059081.6
ENSMUST00000180021.1
Il18

interleukin 18

chr7_-_119895446 0.147 ENSMUST00000098080.2
Dcun1d3
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr8_+_112570043 0.137 ENSMUST00000034225.6
ENSMUST00000118171.1
Cntnap4

contactin associated protein-like 4

chr13_-_21402688 0.126 ENSMUST00000117721.1
ENSMUST00000070785.8
ENSMUST00000116433.1
ENSMUST00000116434.3
Zkscan3



zinc finger with KRAB and SCAN domains 3



chr9_-_50659780 0.097 ENSMUST00000034567.3
Dlat
dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)
chr4_-_148500449 0.092 ENSMUST00000030840.3
Angptl7
angiopoietin-like 7
chr16_+_75592844 0.091 ENSMUST00000114249.1
ENSMUST00000046378.7
ENSMUST00000114253.1
Rbm11


RNA binding motif protein 11


chr5_+_135064206 0.091 ENSMUST00000071263.5
Dnajc30
DnaJ (Hsp40) homolog, subfamily C, member 30
chr11_-_23895208 0.089 ENSMUST00000102863.2
ENSMUST00000020513.3
Papolg

poly(A) polymerase gamma

chr3_+_79885930 0.077 ENSMUST00000029567.8
Fam198b
family with sequence similarity 198, member B
chr4_+_21879662 0.069 ENSMUST00000029909.2
Coq3
coenzyme Q3 homolog, methyltransferase (yeast)
chrX_-_136868537 0.065 ENSMUST00000058814.6
Rab9b
RAB9B, member RAS oncogene family
chr1_+_59256906 0.060 ENSMUST00000160662.1
ENSMUST00000114248.2
Cdk15

cyclin-dependent kinase 15

chr14_+_124005355 0.039 ENSMUST00000166105.1
Gm17615
predicted gene, 17615
chr14_+_77156733 0.020 ENSMUST00000022589.7
Enox1
ecto-NOX disulfide-thiol exchanger 1

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.6 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.9 5.5 GO:0042045 epithelial fluid transport(GO:0042045)
0.7 4.1 GO:0009405 pathogenesis(GO:0009405)
0.6 2.4 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.5 2.2 GO:2000110 protein sialylation(GO:1990743) negative regulation of macrophage apoptotic process(GO:2000110)
0.4 1.9 GO:0034441 plasma lipoprotein particle oxidation(GO:0034441)
0.3 5.6 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.3 1.8 GO:0003350 pulmonary myocardium development(GO:0003350)
0.3 1.3 GO:0035022 positive regulation of Rac protein signal transduction(GO:0035022)
0.2 1.2 GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996)
0.2 1.3 GO:1904749 regulation of protein localization to nucleolus(GO:1904749)
0.2 0.8 GO:0021773 striatal medium spiny neuron differentiation(GO:0021773)
0.2 2.1 GO:0042118 endothelial cell activation(GO:0042118)
0.2 5.2 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.2 0.9 GO:0070197 meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240)
0.1 1.0 GO:0035826 hypotonic response(GO:0006971) rubidium ion transport(GO:0035826) cellular hypotonic response(GO:0071476)
0.1 2.9 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.1 0.7 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.1 0.3 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.1 6.1 GO:0043392 negative regulation of DNA binding(GO:0043392)
0.1 0.8 GO:0034983 peptidyl-lysine deacetylation(GO:0034983)
0.1 0.3 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.1 0.8 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 0.5 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 0.6 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
0.1 2.7 GO:1902476 chloride transmembrane transport(GO:1902476)
0.1 2.5 GO:0010591 regulation of lamellipodium assembly(GO:0010591)
0.1 0.3 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.0 7.3 GO:0030010 establishment of cell polarity(GO:0030010)
0.0 0.2 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.0 0.5 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 1.1 GO:0010761 fibroblast migration(GO:0010761)
0.0 0.3 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.9 GO:0032755 positive regulation of interleukin-6 production(GO:0032755)
0.0 0.2 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.1 GO:2000773 negative regulation of cellular senescence(GO:2000773)
0.0 0.1 GO:2000821 regulation of grooming behavior(GO:2000821)
0.0 0.4 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 0.4 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.0 0.1 GO:0010225 response to UV-C(GO:0010225)
0.0 2.3 GO:0006275 regulation of DNA replication(GO:0006275)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.5 GO:0031088 platelet dense granule membrane(GO:0031088)
1.7 5.0 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.3 0.8 GO:0043512 inhibin A complex(GO:0043512)
0.3 2.4 GO:0097427 microtubule bundle(GO:0097427)
0.2 2.2 GO:0000138 Golgi trans cisterna(GO:0000138)
0.1 1.9 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.1 3.6 GO:0030673 axolemma(GO:0030673)
0.1 0.3 GO:0005588 collagen type V trimer(GO:0005588)
0.1 1.3 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.1 6.4 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 0.9 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.1 1.8 GO:0043194 axon initial segment(GO:0043194)
0.1 0.8 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.2 GO:1990393 3M complex(GO:1990393)
0.0 0.1 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.0 0.3 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.9 GO:0016592 mediator complex(GO:0016592)
0.0 2.7 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.5 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
1.2 5.0 GO:0050436 microfibril binding(GO:0050436)
0.5 2.1 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.4 2.2 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.4 3.6 GO:0008046 axon guidance receptor activity(GO:0008046)
0.3 4.1 GO:0015643 toxic substance binding(GO:0015643)
0.3 2.4 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.2 1.9 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.2 2.7 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.2 1.3 GO:0031432 titin binding(GO:0031432)
0.2 1.8 GO:0038191 neuropilin binding(GO:0038191)
0.1 1.0 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.1 0.8 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 0.6 GO:0004954 icosanoid receptor activity(GO:0004953) prostanoid receptor activity(GO:0004954) prostaglandin receptor activity(GO:0004955)
0.1 2.4 GO:0050321 tau-protein kinase activity(GO:0050321)
0.1 5.7 GO:0008146 sulfotransferase activity(GO:0008146)
0.1 2.3 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 1.3 GO:0001054 RNA polymerase I activity(GO:0001054)
0.1 0.3 GO:0004661 protein geranylgeranyltransferase activity(GO:0004661)
0.1 0.2 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.0 0.3 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 2.0 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 1.7 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.8 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.5 GO:0031402 sodium ion binding(GO:0031402)
0.0 0.4 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 0.8 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.1 GO:0016417 S-acyltransferase activity(GO:0016417)
0.0 0.7 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.0 3.3 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.0 0.8 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.1 GO:0008169 C-methyltransferase activity(GO:0008169)
0.0 1.1 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 0.1 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.6 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.4 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 6.8 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 2.2 PID_BMP_PATHWAY BMP receptor signaling
0.0 5.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.2 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.8 PID_ALK1_PATHWAY ALK1 signaling events
0.0 1.1 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 2.1 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 1.2 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 1.1 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 1.6 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 0.5 PID_EPO_PATHWAY EPO signaling pathway
0.0 1.6 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.2 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.2 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.2 0.6 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.2 0.8 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.1 4.7 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.1 1.9 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 5.7 REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.1 2.2 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.1 2.1 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 1.3 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 1.3 REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 0.8 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.0 0.5 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.8 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription