Motif ID: Fli1
Z-value: 1.476

Transcription factors associated with Fli1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Fli1 | ENSMUSG00000016087.7 | Fli1 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Fli1 | mm10_v2_chr9_-_32541589_32541602 | 0.32 | 2.0e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.2 | 3.5 | GO:0018199 | peptidyl-glutamine modification(GO:0018199) |
0.8 | 8.6 | GO:0032096 | negative regulation of response to food(GO:0032096) negative regulation of appetite(GO:0032099) |
0.8 | 2.3 | GO:0071336 | white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350) regulation of hair follicle cell proliferation(GO:0071336) positive regulation of hair follicle cell proliferation(GO:0071338) |
0.5 | 3.1 | GO:1903056 | positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056) |
0.5 | 14.3 | GO:0048268 | clathrin coat assembly(GO:0048268) |
0.5 | 2.5 | GO:0070459 | prolactin secretion(GO:0070459) |
0.5 | 5.2 | GO:0010650 | positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
0.4 | 1.2 | GO:1902528 | regulation of protein linear polyubiquitination(GO:1902528) positive regulation of protein linear polyubiquitination(GO:1902530) |
0.4 | 4.6 | GO:0051823 | radial glia guided migration of Purkinje cell(GO:0021942) regulation of synapse structural plasticity(GO:0051823) |
0.3 | 1.3 | GO:1905167 | positive regulation of lysosomal protein catabolic process(GO:1905167) |
0.3 | 4.1 | GO:0019433 | triglyceride catabolic process(GO:0019433) |
0.3 | 0.9 | GO:0032817 | regulation of natural killer cell proliferation(GO:0032817) positive regulation of natural killer cell proliferation(GO:0032819) |
0.2 | 0.9 | GO:0002924 | negative regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002924) |
0.2 | 1.9 | GO:0016198 | axon choice point recognition(GO:0016198) |
0.2 | 5.3 | GO:0045838 | positive regulation of membrane potential(GO:0045838) |
0.2 | 3.3 | GO:0007095 | mitotic G2 DNA damage checkpoint(GO:0007095) |
0.2 | 12.9 | GO:0042147 | retrograde transport, endosome to Golgi(GO:0042147) |
0.2 | 1.1 | GO:0032264 | IMP salvage(GO:0032264) |
0.1 | 0.9 | GO:0034587 | piRNA metabolic process(GO:0034587) |
0.1 | 5.9 | GO:0006779 | porphyrin-containing compound biosynthetic process(GO:0006779) |
0.1 | 1.0 | GO:0007342 | fusion of sperm to egg plasma membrane(GO:0007342) |
0.1 | 1.7 | GO:1901898 | regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898) |
0.1 | 0.5 | GO:0015825 | L-serine transport(GO:0015825) |
0.1 | 1.6 | GO:0097119 | postsynaptic density protein 95 clustering(GO:0097119) |
0.1 | 0.4 | GO:0060282 | positive regulation of oocyte development(GO:0060282) |
0.1 | 12.3 | GO:0008277 | regulation of G-protein coupled receptor protein signaling pathway(GO:0008277) |
0.1 | 0.4 | GO:0070318 | positive regulation of G0 to G1 transition(GO:0070318) |
0.1 | 0.3 | GO:0034287 | detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594) |
0.1 | 0.8 | GO:0033089 | positive regulation of T cell differentiation in thymus(GO:0033089) regulation of gamma-delta T cell differentiation(GO:0045586) regulation of gamma-delta T cell activation(GO:0046643) positive regulation of thymocyte aggregation(GO:2000400) |
0.1 | 0.4 | GO:0046827 | positive regulation of protein export from nucleus(GO:0046827) |
0.1 | 0.2 | GO:0009644 | response to high light intensity(GO:0009644) |
0.1 | 4.6 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
0.1 | 0.6 | GO:1901096 | regulation of autophagosome maturation(GO:1901096) |
0.0 | 0.8 | GO:0046069 | cGMP catabolic process(GO:0046069) |
0.0 | 1.0 | GO:2000311 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311) |
0.0 | 0.6 | GO:0043402 | glucocorticoid mediated signaling pathway(GO:0043402) |
0.0 | 1.7 | GO:0090162 | establishment of epithelial cell polarity(GO:0090162) |
0.0 | 0.1 | GO:0090024 | negative regulation of granulocyte chemotaxis(GO:0071623) negative regulation of neutrophil chemotaxis(GO:0090024) |
0.0 | 0.3 | GO:0051152 | positive regulation of smooth muscle cell differentiation(GO:0051152) |
0.0 | 0.2 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
0.0 | 0.8 | GO:0015991 | ATP hydrolysis coupled proton transport(GO:0015991) |
0.0 | 0.2 | GO:1902916 | positive regulation of protein polyubiquitination(GO:1902916) |
0.0 | 0.1 | GO:0042117 | monocyte activation(GO:0042117) |
0.0 | 1.6 | GO:0043149 | contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149) |
0.0 | 0.1 | GO:2000774 | positive regulation of cellular senescence(GO:2000774) |
0.0 | 0.1 | GO:0032483 | regulation of Rab protein signal transduction(GO:0032483) |
0.0 | 0.1 | GO:0032596 | protein transport into membrane raft(GO:0032596) dsRNA transport(GO:0033227) |
0.0 | 0.0 | GO:0031053 | primary miRNA processing(GO:0031053) |
0.0 | 0.5 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
0.0 | 0.2 | GO:1902170 | cellular response to reactive nitrogen species(GO:1902170) |
0.0 | 0.1 | GO:0042769 | DNA damage response, detection of DNA damage(GO:0042769) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.8 | 4.5 | GO:0044308 | axonal spine(GO:0044308) |
0.6 | 12.3 | GO:0044292 | dendrite terminus(GO:0044292) |
0.6 | 2.5 | GO:0097487 | vesicle lumen(GO:0031983) multivesicular body, internal vesicle(GO:0097487) |
0.6 | 11.0 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
0.3 | 1.0 | GO:0034667 | integrin alpha3-beta1 complex(GO:0034667) |
0.2 | 12.9 | GO:0045335 | phagocytic vesicle(GO:0045335) |
0.1 | 1.9 | GO:0031527 | filopodium membrane(GO:0031527) |
0.1 | 4.1 | GO:0005811 | lipid particle(GO:0005811) |
0.0 | 0.8 | GO:0033178 | proton-transporting two-sector ATPase complex, catalytic domain(GO:0033178) |
0.0 | 1.7 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
0.0 | 0.4 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
0.0 | 0.2 | GO:1990604 | IRE1-TRAF2-ASK1 complex(GO:1990604) |
0.0 | 3.9 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
0.0 | 1.0 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
0.0 | 1.7 | GO:0031225 | anchored component of membrane(GO:0031225) |
0.0 | 0.6 | GO:0000795 | synaptonemal complex(GO:0000795) |
0.0 | 0.7 | GO:0032420 | stereocilium(GO:0032420) |
0.0 | 14.8 | GO:0005768 | endosome(GO:0005768) |
0.0 | 0.1 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
0.0 | 0.3 | GO:0045180 | basal cortex(GO:0045180) |
0.0 | 0.0 | GO:1903095 | microprocessor complex(GO:0070877) ribonuclease III complex(GO:1903095) |
0.0 | 0.5 | GO:0071011 | precatalytic spliceosome(GO:0071011) |
0.0 | 0.5 | GO:0097440 | apical dendrite(GO:0097440) |
0.0 | 1.2 | GO:0005923 | bicellular tight junction(GO:0005923) |
0.0 | 1.6 | GO:0043197 | dendritic spine(GO:0043197) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.9 | 15.0 | GO:0032051 | clathrin light chain binding(GO:0032051) |
0.9 | 16.8 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
0.9 | 6.2 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) |
0.8 | 2.5 | GO:0005006 | epidermal growth factor-activated receptor activity(GO:0005006) |
0.7 | 5.9 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
0.6 | 2.3 | GO:0005111 | type 2 fibroblast growth factor receptor binding(GO:0005111) |
0.4 | 1.3 | GO:0016964 | alpha-2 macroglobulin receptor activity(GO:0016964) |
0.3 | 3.5 | GO:0016755 | transferase activity, transferring amino-acyl groups(GO:0016755) |
0.2 | 13.0 | GO:0019003 | GDP binding(GO:0019003) |
0.2 | 1.1 | GO:0003876 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
0.1 | 0.8 | GO:0004118 | cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) |
0.1 | 2.7 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
0.1 | 5.2 | GO:0030507 | spectrin binding(GO:0030507) |
0.1 | 0.4 | GO:0031800 | type 3 metabotropic glutamate receptor binding(GO:0031800) |
0.1 | 3.1 | GO:0070412 | R-SMAD binding(GO:0070412) |
0.1 | 0.6 | GO:0043423 | 3-phosphoinositide-dependent protein kinase binding(GO:0043423) |
0.1 | 7.2 | GO:0008083 | growth factor activity(GO:0008083) |
0.1 | 0.8 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
0.1 | 2.1 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
0.1 | 1.6 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
0.0 | 0.1 | GO:0004875 | complement receptor activity(GO:0004875) |
0.0 | 0.3 | GO:0004340 | glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) |
0.0 | 1.2 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
0.0 | 0.5 | GO:0022889 | L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889) |
0.0 | 1.0 | GO:0043236 | laminin binding(GO:0043236) |
0.0 | 0.3 | GO:0005229 | intracellular calcium activated chloride channel activity(GO:0005229) |
0.0 | 0.6 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
0.0 | 1.2 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
0.0 | 0.9 | GO:0050750 | low-density lipoprotein particle receptor binding(GO:0050750) |
0.0 | 4.5 | GO:0017137 | Rab GTPase binding(GO:0017137) |
0.0 | 4.7 | GO:0051015 | actin filament binding(GO:0051015) |
0.0 | 0.8 | GO:0005112 | Notch binding(GO:0005112) |
0.0 | 1.0 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
0.0 | 2.0 | GO:0005249 | voltage-gated potassium channel activity(GO:0005249) |
0.0 | 0.2 | GO:0001846 | opsonin binding(GO:0001846) |
0.0 | 0.2 | GO:0043008 | ATP-dependent protein binding(GO:0043008) |
0.0 | 0.3 | GO:0003785 | actin monomer binding(GO:0003785) |
0.0 | 0.0 | GO:0004525 | ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296) |
0.0 | 0.9 | GO:0005125 | cytokine activity(GO:0005125) |
0.0 | 1.4 | GO:0030674 | protein binding, bridging(GO:0030674) |
0.0 | 1.4 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
0.0 | 0.0 | GO:0031752 | D5 dopamine receptor binding(GO:0031752) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 2.5 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
0.1 | 3.5 | PID_P38_MKK3_6PATHWAY | p38 MAPK signaling pathway |
0.1 | 4.6 | PID_EPHB_FWD_PATHWAY | EPHB forward signaling |
0.1 | 2.3 | PID_UPA_UPAR_PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
0.1 | 0.9 | PID_ANTHRAX_PATHWAY | Cellular roles of Anthrax toxin |
0.1 | 1.2 | SA_CASPASE_CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
0.0 | 1.2 | PID_NCADHERIN_PATHWAY | N-cadherin signaling events |
0.0 | 0.5 | SA_G1_AND_S_PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
0.0 | 1.1 | PID_PS1_PATHWAY | Presenilin action in Notch and Wnt signaling |
0.0 | 0.8 | PID_NFAT_TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
0.0 | 0.4 | PID_AMB2_NEUTROPHILS_PATHWAY | amb2 Integrin signaling |
0.0 | 0.6 | PID_PI3KCI_PATHWAY | Class I PI3K signaling events |
0.0 | 0.9 | PID_LYSOPHOSPHOLIPID_PATHWAY | LPA receptor mediated events |
0.0 | 0.3 | ST_JNK_MAPK_PATHWAY | JNK MAPK Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 11.0 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
0.2 | 2.3 | REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION | Genes involved in FGFR1 ligand binding and activation |
0.2 | 4.5 | REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
0.1 | 2.5 | REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING | Genes involved in SHC1 events in EGFR signaling |
0.1 | 12.3 | REACTOME_G_ALPHA_I_SIGNALLING_EVENTS | Genes involved in G alpha (i) signalling events |
0.1 | 1.1 | REACTOME_PURINE_SALVAGE | Genes involved in Purine salvage |
0.1 | 2.0 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
0.1 | 1.5 | REACTOME_BASIGIN_INTERACTIONS | Genes involved in Basigin interactions |
0.0 | 2.1 | REACTOME_DARPP_32_EVENTS | Genes involved in DARPP-32 events |
0.0 | 1.2 | REACTOME_CGMP_EFFECTS | Genes involved in cGMP effects |
0.0 | 1.0 | REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS | Genes involved in Trafficking of AMPA receptors |
0.0 | 4.2 | REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
0.0 | 0.8 | REACTOME_INSULIN_RECEPTOR_RECYCLING | Genes involved in Insulin receptor recycling |
0.0 | 0.2 | REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
0.0 | 1.2 | REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
0.0 | 0.5 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
0.0 | 0.9 | REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
0.0 | 0.2 | REACTOME_PHOSPHORYLATION_OF_THE_APC_C | Genes involved in Phosphorylation of the APC/C |
0.0 | 0.2 | REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |