Motif ID: Hoxd11_Cdx1_Hoxc11
Z-value: 0.667



Transcription factors associated with Hoxd11_Cdx1_Hoxc11:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Cdx1 | ENSMUSG00000024619.8 | Cdx1 |
Hoxc11 | ENSMUSG00000001656.3 | Hoxc11 |
Hoxd11 | ENSMUSG00000042499.12 | Hoxd11 |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.8 | 3.2 | GO:0048686 | regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690) |
0.6 | 2.3 | GO:0090126 | protein complex assembly involved in synapse maturation(GO:0090126) |
0.5 | 5.1 | GO:0042572 | retinol metabolic process(GO:0042572) |
0.3 | 0.8 | GO:0060478 | acrosomal vesicle exocytosis(GO:0060478) |
0.2 | 0.9 | GO:0038128 | ERBB2 signaling pathway(GO:0038128) |
0.2 | 0.9 | GO:0014012 | peripheral nervous system axon regeneration(GO:0014012) |
0.2 | 1.0 | GO:1903566 | positive regulation of protein localization to cilium(GO:1903566) |
0.2 | 0.8 | GO:0019236 | response to pheromone(GO:0019236) |
0.1 | 0.7 | GO:0045163 | clustering of voltage-gated potassium channels(GO:0045163) |
0.1 | 1.9 | GO:0021902 | commitment of neuronal cell to specific neuron type in forebrain(GO:0021902) |
0.1 | 0.5 | GO:2000325 | regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327) |
0.1 | 0.2 | GO:0034372 | very-low-density lipoprotein particle remodeling(GO:0034372) |
0.1 | 1.0 | GO:0010459 | negative regulation of heart rate(GO:0010459) |
0.1 | 0.4 | GO:0097343 | ripoptosome assembly(GO:0097343) ripoptosome assembly involved in necroptotic process(GO:1901026) |
0.1 | 0.8 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
0.1 | 1.6 | GO:0046069 | cGMP catabolic process(GO:0046069) |
0.1 | 0.5 | GO:1902261 | positive regulation of delayed rectifier potassium channel activity(GO:1902261) |
0.1 | 0.2 | GO:0071929 | alpha-tubulin acetylation(GO:0071929) |
0.1 | 0.2 | GO:0007525 | somatic muscle development(GO:0007525) |
0.1 | 0.5 | GO:0016584 | nucleosome positioning(GO:0016584) |
0.1 | 0.3 | GO:0001692 | histamine metabolic process(GO:0001692) imidazole-containing compound catabolic process(GO:0052805) |
0.1 | 0.4 | GO:1903056 | positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056) |
0.1 | 1.3 | GO:0001516 | prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457) |
0.1 | 0.8 | GO:0043653 | mitochondrial fragmentation involved in apoptotic process(GO:0043653) |
0.1 | 0.6 | GO:0090527 | actin filament reorganization(GO:0090527) |
0.1 | 0.6 | GO:0042118 | endothelial cell activation(GO:0042118) |
0.1 | 0.4 | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) |
0.1 | 0.6 | GO:0010650 | positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
0.0 | 0.2 | GO:0010511 | regulation of phosphatidylinositol biosynthetic process(GO:0010511) |
0.0 | 0.9 | GO:0097113 | AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688) |
0.0 | 0.9 | GO:0001886 | endothelial cell morphogenesis(GO:0001886) |
0.0 | 0.8 | GO:0007379 | segment specification(GO:0007379) |
0.0 | 0.2 | GO:0097393 | post-embryonic appendage morphogenesis(GO:0035120) post-embryonic limb morphogenesis(GO:0035127) post-embryonic forelimb morphogenesis(GO:0035128) telomeric repeat-containing RNA transcription(GO:0097393) telomeric repeat-containing RNA transcription from RNA pol II promoter(GO:0097394) regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901580) negative regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901581) positive regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901582) |
0.0 | 0.3 | GO:0060923 | cardiac muscle cell fate commitment(GO:0060923) |
0.0 | 3.6 | GO:0043488 | regulation of mRNA stability(GO:0043488) |
0.0 | 0.4 | GO:2000741 | positive regulation of mesenchymal stem cell differentiation(GO:2000741) |
0.0 | 0.4 | GO:0019321 | pentose metabolic process(GO:0019321) |
0.0 | 0.2 | GO:0043654 | recognition of apoptotic cell(GO:0043654) |
0.0 | 0.4 | GO:1901898 | negative regulation of relaxation of cardiac muscle(GO:1901898) |
0.0 | 0.3 | GO:1900034 | regulation of cellular response to heat(GO:1900034) |
0.0 | 0.1 | GO:1902256 | apoptotic process involved in outflow tract morphogenesis(GO:0003275) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256) |
0.0 | 0.5 | GO:0060218 | hematopoietic stem cell differentiation(GO:0060218) |
0.0 | 0.1 | GO:0042360 | vitamin E metabolic process(GO:0042360) |
0.0 | 0.0 | GO:0051238 | sequestering of metal ion(GO:0051238) |
0.0 | 0.3 | GO:0042541 | hemoglobin biosynthetic process(GO:0042541) |
0.0 | 0.5 | GO:0010800 | positive regulation of peptidyl-threonine phosphorylation(GO:0010800) |
0.0 | 0.1 | GO:0009838 | abscission(GO:0009838) |
0.0 | 0.5 | GO:0015813 | L-glutamate transport(GO:0015813) |
0.0 | 0.0 | GO:0003345 | proepicardium cell migration involved in pericardium morphogenesis(GO:0003345) |
0.0 | 0.1 | GO:0002674 | negative regulation of acute inflammatory response(GO:0002674) |
0.0 | 0.2 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
0.0 | 0.1 | GO:1900121 | negative regulation of receptor binding(GO:1900121) |
0.0 | 0.3 | GO:0032291 | central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291) |
0.0 | 0.3 | GO:0045063 | T-helper 1 cell differentiation(GO:0045063) |
0.0 | 0.2 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
0.0 | 0.4 | GO:0007097 | nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023) |
0.0 | 0.3 | GO:0046854 | phosphatidylinositol phosphorylation(GO:0046854) |
0.0 | 0.5 | GO:0007212 | dopamine receptor signaling pathway(GO:0007212) |
0.0 | 0.2 | GO:0090110 | cargo loading into COPII-coated vesicle(GO:0090110) |
0.0 | 0.1 | GO:0035434 | copper ion transmembrane transport(GO:0035434) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.1 | 3.2 | GO:0072534 | perineuronal net(GO:0072534) |
0.3 | 2.3 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
0.1 | 1.8 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
0.1 | 1.3 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
0.1 | 0.9 | GO:0005614 | interstitial matrix(GO:0005614) |
0.1 | 0.8 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
0.1 | 0.2 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
0.0 | 0.3 | GO:0005882 | intermediate filament(GO:0005882) |
0.0 | 0.2 | GO:1990421 | subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707) |
0.0 | 0.2 | GO:0032437 | cuticular plate(GO:0032437) |
0.0 | 0.5 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
0.0 | 0.6 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
0.0 | 1.1 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
0.0 | 0.9 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
0.0 | 2.1 | GO:0000118 | histone deacetylase complex(GO:0000118) |
0.0 | 0.8 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
0.0 | 0.2 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
0.0 | 0.8 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
0.0 | 0.2 | GO:0070852 | cell body fiber(GO:0070852) |
0.0 | 0.4 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
0.0 | 0.1 | GO:0002177 | manchette(GO:0002177) |
0.0 | 0.2 | GO:0030127 | COPII vesicle coat(GO:0030127) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.7 | 5.1 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
0.3 | 1.3 | GO:0050220 | prostaglandin-E synthase activity(GO:0050220) |
0.2 | 1.0 | GO:0043125 | ErbB-3 class receptor binding(GO:0043125) |
0.2 | 2.3 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
0.2 | 3.2 | GO:0046625 | sphingolipid binding(GO:0046625) |
0.2 | 0.6 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
0.1 | 0.9 | GO:0045545 | syndecan binding(GO:0045545) |
0.1 | 0.7 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
0.1 | 0.3 | GO:0016748 | succinyltransferase activity(GO:0016748) |
0.1 | 1.6 | GO:0047555 | 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555) |
0.1 | 0.5 | GO:0008607 | phosphorylase kinase regulator activity(GO:0008607) |
0.1 | 0.2 | GO:0004993 | G-protein coupled serotonin receptor activity(GO:0004993) |
0.1 | 1.0 | GO:0016208 | AMP binding(GO:0016208) |
0.1 | 0.3 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
0.0 | 0.6 | GO:0005314 | high-affinity glutamate transmembrane transporter activity(GO:0005314) |
0.0 | 0.8 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
0.0 | 0.2 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
0.0 | 0.8 | GO:0031402 | sodium ion binding(GO:0031402) |
0.0 | 1.0 | GO:0043422 | protein kinase B binding(GO:0043422) |
0.0 | 0.2 | GO:0004984 | olfactory receptor activity(GO:0004984) |
0.0 | 3.6 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
0.0 | 0.9 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
0.0 | 0.2 | GO:0034186 | apolipoprotein A-I binding(GO:0034186) |
0.0 | 0.6 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
0.0 | 3.3 | GO:0005057 | receptor signaling protein activity(GO:0005057) |
0.0 | 0.2 | GO:0015616 | DNA translocase activity(GO:0015616) |
0.0 | 0.1 | GO:0008061 | chitin binding(GO:0008061) |
0.0 | 0.3 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
0.0 | 1.0 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
0.0 | 0.8 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
0.0 | 0.4 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
0.0 | 0.5 | GO:0032183 | SUMO binding(GO:0032183) |
0.0 | 0.1 | GO:0046975 | histone methyltransferase activity (H3-K36 specific)(GO:0046975) |
0.0 | 0.1 | GO:0050265 | RNA uridylyltransferase activity(GO:0050265) |
0.0 | 0.3 | GO:0030159 | receptor signaling complex scaffold activity(GO:0030159) |
0.0 | 1.3 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
0.0 | 0.4 | GO:0070412 | R-SMAD binding(GO:0070412) |
0.0 | 0.4 | GO:0030552 | cAMP binding(GO:0030552) |
0.0 | 1.1 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
0.0 | 0.2 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
0.0 | 0.2 | GO:0031489 | myosin V binding(GO:0031489) |
0.0 | 0.4 | GO:0019200 | carbohydrate kinase activity(GO:0019200) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 2.0 | PID_INTEGRIN_A9B1_PATHWAY | Alpha9 beta1 integrin signaling events |
0.1 | 4.3 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
0.1 | 0.7 | PID_RHODOPSIN_PATHWAY | Visual signal transduction: Rods |
0.1 | 1.0 | PID_IL5_PATHWAY | IL5-mediated signaling events |
0.0 | 0.4 | PID_TCR_JNK_PATHWAY | JNK signaling in the CD4+ TCR pathway |
0.0 | 2.1 | PID_RAC1_REG_PATHWAY | Regulation of RAC1 activity |
0.0 | 1.3 | PID_IFNG_PATHWAY | IFN-gamma pathway |
0.0 | 1.0 | PID_ARF6_PATHWAY | Arf6 signaling events |
0.0 | 3.2 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
0.0 | 0.8 | PID_ATR_PATHWAY | ATR signaling pathway |
0.0 | 1.3 | PID_AR_TF_PATHWAY | Regulation of Androgen receptor activity |
0.0 | 0.3 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
0.0 | 1.2 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 1.0 | REACTOME_IL_7_SIGNALING | Genes involved in Interleukin-7 signaling |
0.1 | 0.2 | REACTOME_SEROTONIN_RECEPTORS | Genes involved in Serotonin receptors |
0.1 | 1.6 | REACTOME_CGMP_EFFECTS | Genes involved in cGMP effects |
0.0 | 0.4 | REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION | Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
0.0 | 0.5 | REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
0.0 | 0.5 | REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
0.0 | 0.4 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
0.0 | 2.1 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
0.0 | 0.7 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
0.0 | 0.1 | REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |
0.0 | 0.2 | REACTOME_HDL_MEDIATED_LIPID_TRANSPORT | Genes involved in HDL-mediated lipid transport |
0.0 | 0.3 | REACTOME_METABOLISM_OF_PORPHYRINS | Genes involved in Metabolism of porphyrins |
0.0 | 0.3 | REACTOME_N_GLYCAN_ANTENNAE_ELONGATION | Genes involved in N-Glycan antennae elongation |
0.0 | 0.5 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
0.0 | 1.2 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |