Motif ID: Foxo3

Z-value: 0.967


Transcription factors associated with Foxo3:

Gene SymbolEntrez IDGene Name
Foxo3 ENSMUSG00000048756.5 Foxo3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxo3mm10_v2_chr10_-_42276744_422767630.736.4e-04Click!


Activity profile for motif Foxo3.

activity profile for motif Foxo3


Sorted Z-values histogram for motif Foxo3

Sorted Z-values for motif Foxo3



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxo3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_84773381 3.959 ENSMUST00000109764.1
Nfix
nuclear factor I/X
chr10_+_112271123 3.066 ENSMUST00000092175.2
Kcnc2
potassium voltage gated channel, Shaw-related subfamily, member 2
chr11_+_3332426 2.820 ENSMUST00000136474.1
Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr7_+_82175156 2.251 ENSMUST00000180243.1
Sh3gl3
SH3-domain GRB2-like 3
chr4_-_116405986 2.222 ENSMUST00000123072.1
ENSMUST00000144281.1
Mast2

microtubule associated serine/threonine kinase 2

chrX_+_159697308 2.199 ENSMUST00000123433.1
Sh3kbp1
SH3-domain kinase binding protein 1
chr6_+_55836878 2.160 ENSMUST00000044729.6
Ccdc129
coiled-coil domain containing 129
chr14_-_121698417 2.093 ENSMUST00000040700.7
Dock9
dedicator of cytokinesis 9
chr11_+_29463735 1.912 ENSMUST00000155854.1
Ccdc88a
coiled coil domain containing 88A
chr4_-_87806276 1.847 ENSMUST00000148059.1
Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr11_-_101785252 1.839 ENSMUST00000164750.1
ENSMUST00000107176.1
ENSMUST00000017868.6
Etv4


ets variant gene 4 (E1A enhancer binding protein, E1AF)


chr2_+_136713444 1.819 ENSMUST00000028727.4
ENSMUST00000110098.3
Snap25

synaptosomal-associated protein 25

chr11_+_85353156 1.728 ENSMUST00000108061.1
ENSMUST00000108062.1
ENSMUST00000108056.1
ENSMUST00000138423.1
ENSMUST00000074875.4
ENSMUST00000092821.3
Bcas3





breast carcinoma amplified sequence 3





chr4_-_87806296 1.727 ENSMUST00000126353.1
ENSMUST00000149357.1
Mllt3

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

chr3_+_63295815 1.712 ENSMUST00000029400.1
Mme
membrane metallo endopeptidase
chr16_+_93683184 1.706 ENSMUST00000039620.6
Cbr3
carbonyl reductase 3
chr5_+_66968559 1.689 ENSMUST00000127184.1
Limch1
LIM and calponin homology domains 1
chr16_-_43979050 1.521 ENSMUST00000165648.1
ENSMUST00000036321.7
Zdhhc23

zinc finger, DHHC domain containing 23

chr7_-_103813913 1.517 ENSMUST00000098192.3
Hbb-bt
hemoglobin, beta adult t chain
chr11_-_60352869 1.505 ENSMUST00000095254.5
ENSMUST00000102683.4
ENSMUST00000093048.6
ENSMUST00000093046.6
ENSMUST00000064019.8
ENSMUST00000102682.4
Tom1l2





target of myb1-like 2 (chicken)





chr10_+_40349265 1.482 ENSMUST00000044672.4
ENSMUST00000095743.2
Cdk19

cyclin-dependent kinase 19

chr1_+_66386968 1.456 ENSMUST00000145419.1
Map2
microtubule-associated protein 2
chrX_+_85574018 1.378 ENSMUST00000048250.3
ENSMUST00000137438.1
ENSMUST00000146063.1
Tab3


TGF-beta activated kinase 1/MAP3K7 binding protein 3


chr5_+_66968416 1.325 ENSMUST00000038188.7
Limch1
LIM and calponin homology domains 1
chr11_+_19924403 1.229 ENSMUST00000093298.5
Spred2
sprouty-related, EVH1 domain containing 2
chr18_+_37513652 1.164 ENSMUST00000061405.4
Pcdhb21
protocadherin beta 21
chr16_-_22439719 1.133 ENSMUST00000079601.6
Etv5
ets variant gene 5
chr7_+_30291941 1.096 ENSMUST00000144508.1
Clip3
CAP-GLY domain containing linker protein 3
chr4_-_155345696 1.066 ENSMUST00000103178.4
Prkcz
protein kinase C, zeta
chr7_+_113765998 1.043 ENSMUST00000046687.9
Spon1
spondin 1, (f-spondin) extracellular matrix protein
chr19_-_42086338 0.994 ENSMUST00000051772.8
Morn4
MORN repeat containing 4
chr4_-_91376433 0.969 ENSMUST00000107109.2
ENSMUST00000107111.2
ENSMUST00000107120.1
Elavl2


ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)


chr3_-_146770218 0.884 ENSMUST00000106137.1
Prkacb
protein kinase, cAMP dependent, catalytic, beta
chr2_-_7081256 0.842 ENSMUST00000183209.1
Celf2
CUGBP, Elav-like family member 2
chr7_+_30291659 0.820 ENSMUST00000014065.8
ENSMUST00000150892.1
ENSMUST00000126216.1
Clip3


CAP-GLY domain containing linker protein 3


chr14_+_84443553 0.811 ENSMUST00000071370.5
Pcdh17
protocadherin 17
chr10_-_93310963 0.776 ENSMUST00000151153.1
Elk3
ELK3, member of ETS oncogene family
chr8_-_41016295 0.769 ENSMUST00000131965.1
Mtus1
mitochondrial tumor suppressor 1
chr10_-_93311073 0.703 ENSMUST00000008542.5
Elk3
ELK3, member of ETS oncogene family
chr4_-_91376490 0.695 ENSMUST00000107124.3
Elavl2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr7_+_24907618 0.679 ENSMUST00000151121.1
Arhgef1
Rho guanine nucleotide exchange factor (GEF) 1
chr10_-_5069044 0.674 ENSMUST00000095899.3
Syne1
spectrin repeat containing, nuclear envelope 1
chr6_-_39725193 0.657 ENSMUST00000101497.3
Braf
Braf transforming gene
chr2_-_104493690 0.649 ENSMUST00000111124.1
Hipk3
homeodomain interacting protein kinase 3
chr7_+_113766119 0.630 ENSMUST00000084696.4
Spon1
spondin 1, (f-spondin) extracellular matrix protein
chr2_-_120245157 0.622 ENSMUST00000090071.4
Pla2g4e
phospholipase A2, group IVE
chr8_-_41016749 0.622 ENSMUST00000117735.1
Mtus1
mitochondrial tumor suppressor 1
chr2_+_3513035 0.581 ENSMUST00000036350.2
Cdnf
cerebral dopamine neurotrophic factor
chr12_-_85270564 0.574 ENSMUST00000019378.6
ENSMUST00000166821.1
Mlh3

mutL homolog 3 (E coli)

chr11_+_19924354 0.560 ENSMUST00000093299.6
Spred2
sprouty-related, EVH1 domain containing 2
chr14_-_51913393 0.555 ENSMUST00000004673.7
ENSMUST00000111632.3
Ndrg2

N-myc downstream regulated gene 2

chr3_+_5218516 0.532 ENSMUST00000175866.1
Zfhx4
zinc finger homeodomain 4
chr1_+_24005505 0.528 ENSMUST00000181961.1
Gm26524
predicted gene, 26524
chr2_-_91710519 0.509 ENSMUST00000028678.8
ENSMUST00000076803.5
Atg13

autophagy related 13

chr8_+_71568866 0.508 ENSMUST00000034267.4
Slc27a1
solute carrier family 27 (fatty acid transporter), member 1
chr13_+_60602182 0.503 ENSMUST00000044083.7
Dapk1
death associated protein kinase 1
chr19_-_19111181 0.480 ENSMUST00000112832.1
Rorb
RAR-related orphan receptor beta
chr5_-_123140135 0.478 ENSMUST00000160099.1
AI480526
expressed sequence AI480526
chr2_-_51972990 0.463 ENSMUST00000145481.1
ENSMUST00000112705.2
Nmi

N-myc (and STAT) interactor

chr2_-_51973219 0.460 ENSMUST00000028314.2
Nmi
N-myc (and STAT) interactor
chr14_+_30879257 0.446 ENSMUST00000040715.6
Mustn1
musculoskeletal, embryonic nuclear protein 1
chr18_-_74961252 0.443 ENSMUST00000066532.4
Lipg
lipase, endothelial
chr6_+_14901440 0.439 ENSMUST00000128567.1
Foxp2
forkhead box P2
chr2_+_124610573 0.432 ENSMUST00000103239.3
ENSMUST00000103240.2
Sema6d

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D

chr19_-_28010995 0.415 ENSMUST00000172907.1
ENSMUST00000046898.9
Rfx3

regulatory factor X, 3 (influences HLA class II expression)

chr1_+_75142775 0.415 ENSMUST00000097694.4
Fam134a
family with sequence similarity 134, member A
chr9_-_48835932 0.414 ENSMUST00000093852.3
Zbtb16
zinc finger and BTB domain containing 16
chr4_-_119415494 0.327 ENSMUST00000063642.2
Ccdc30
coiled-coil domain containing 30
chr3_+_5218589 0.326 ENSMUST00000177488.1
Zfhx4
zinc finger homeodomain 4
chr14_-_52213379 0.318 ENSMUST00000140603.1
Chd8
chromodomain helicase DNA binding protein 8
chr19_-_28011138 0.313 ENSMUST00000174850.1
Rfx3
regulatory factor X, 3 (influences HLA class II expression)
chr8_-_64205970 0.269 ENSMUST00000066166.4
Tll1
tolloid-like
chr1_+_17601893 0.249 ENSMUST00000088476.2
Pi15
peptidase inhibitor 15
chr2_+_124610278 0.228 ENSMUST00000051419.8
ENSMUST00000077847.5
ENSMUST00000078621.5
ENSMUST00000076335.5
Sema6d



sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D



chr1_+_36511867 0.214 ENSMUST00000001166.7
ENSMUST00000097776.3
Cnnm3

cyclin M3

chr17_+_43389436 0.207 ENSMUST00000113599.1
Gpr116
G protein-coupled receptor 116
chr3_-_30793549 0.185 ENSMUST00000180833.1
4933429H19Rik
RIKEN cDNA 4933429H19 gene
chr17_+_24840108 0.177 ENSMUST00000164251.1
Hagh
hydroxyacyl glutathione hydrolase
chr5_-_151190154 0.174 ENSMUST00000062015.8
ENSMUST00000110483.2
Stard13

StAR-related lipid transfer (START) domain containing 13

chr9_+_114731177 0.166 ENSMUST00000035007.8
Cmtm6
CKLF-like MARVEL transmembrane domain containing 6
chr11_-_48946148 0.150 ENSMUST00000104958.1
Psme2b
protease (prosome, macropain) activator subunit 2B
chr7_+_29309429 0.147 ENSMUST00000137848.1
Dpf1
D4, zinc and double PHD fingers family 1
chr12_+_38780817 0.134 ENSMUST00000160856.1
Etv1
ets variant gene 1
chr12_-_31499541 0.119 ENSMUST00000101499.3
ENSMUST00000064240.6
ENSMUST00000085487.5
Cbll1


Casitas B-lineage lymphoma-like 1


chr8_-_122476036 0.096 ENSMUST00000014614.3
Rnf166
ring finger protein 166
chr3_+_5218546 0.093 ENSMUST00000026284.6
Zfhx4
zinc finger homeodomain 4
chr6_-_39206782 0.088 ENSMUST00000002305.8
Jhdm1d
jumonji C domain-containing histone demethylase 1 homolog D (S. cerevisiae)
chr1_-_163403627 0.069 ENSMUST00000045138.4
Gorab
golgin, RAB6-interacting
chr6_-_83831736 0.068 ENSMUST00000058383.8
Paip2b
poly(A) binding protein interacting protein 2B
chr11_+_60353324 0.064 ENSMUST00000070805.6
ENSMUST00000094140.2
ENSMUST00000108723.2
ENSMUST00000108722.4
Lrrc48



leucine rich repeat containing 48



chr4_-_134915010 0.064 ENSMUST00000105863.1
ENSMUST00000030626.5
Tmem50a

transmembrane protein 50A

chr10_+_128303322 0.059 ENSMUST00000005825.6
Pan2
PAN2 polyA specific ribonuclease subunit homolog (S. cerevisiae)
chr12_+_71016658 0.057 ENSMUST00000125125.1
Arid4a
AT rich interactive domain 4A (RBP1-like)
chr2_+_91710900 0.046 ENSMUST00000142692.1
ENSMUST00000090608.5
Harbi1

harbinger transposase derived 1

chr18_-_39489776 0.020 ENSMUST00000025300.6
Nr3c1
nuclear receptor subfamily 3, group C, member 1
chr8_-_25785154 0.018 ENSMUST00000038498.8
Bag4
BCL2-associated athanogene 4
chr5_+_65131184 0.013 ENSMUST00000031089.5
ENSMUST00000101191.3
Klhl5

kelch-like 5

chr18_-_39489880 0.012 ENSMUST00000152853.1
Nr3c1
nuclear receptor subfamily 3, group C, member 1
chr7_+_130692532 0.009 ENSMUST00000033141.6
Tacc2
transforming, acidic coiled-coil containing protein 2
chr2_+_76675265 0.007 ENSMUST00000111920.1
Plekha3
pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 3
chr12_+_71170589 0.000 ENSMUST00000129376.1
2700049A03Rik
RIKEN cDNA 2700049A03 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0071492 cellular response to UV-A(GO:0071492)
0.4 3.0 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.4 2.8 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.4 1.9 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.3 0.9 GO:1902524 interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.3 2.2 GO:0045075 interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.3 3.1 GO:1903818 positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.2 1.9 GO:0072321 chaperone-mediated protein transport(GO:0072321)
0.2 1.8 GO:0098967 exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967)
0.2 3.6 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.2 4.0 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.2 1.1 GO:2000551 regulation of T-helper 2 cell cytokine production(GO:2000551) positive regulation of T-helper 2 cell cytokine production(GO:2000553)
0.2 0.7 GO:0002069 columnar/cuboidal epithelial cell maturation(GO:0002069)
0.2 2.3 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.1 0.4 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.1 0.7 GO:0090292 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.1 1.7 GO:0042182 ketone catabolic process(GO:0042182)
0.1 1.8 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.1 0.5 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.1 0.4 GO:0010986 positive regulation of lipoprotein particle clearance(GO:0010986)
0.1 0.7 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.1 1.7 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.1 0.4 GO:1902732 positive regulation of chondrocyte proliferation(GO:1902732)
0.1 0.6 GO:0007144 female meiosis I(GO:0007144)
0.1 0.9 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.1 0.5 GO:0046549 retinal cone cell development(GO:0046549)
0.1 0.8 GO:2000807 regulation of synaptic vesicle clustering(GO:2000807)
0.1 1.4 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.0 1.3 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.6 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.0 0.6 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.0 0.1 GO:1901620 regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901620)
0.0 1.5 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.0 0.3 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.0 0.5 GO:0098780 response to mitochondrial depolarisation(GO:0098780)
0.0 1.5 GO:0045839 negative regulation of mitotic nuclear division(GO:0045839)
0.0 0.5 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.0 1.5 GO:0050729 positive regulation of inflammatory response(GO:0050729)
0.0 0.7 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.0 0.8 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.6 GO:0009395 phospholipid catabolic process(GO:0009395)
0.0 0.6 GO:0048662 negative regulation of smooth muscle cell proliferation(GO:0048662)
0.0 0.2 GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis(GO:0090051)
0.0 3.0 GO:0031032 actomyosin structure organization(GO:0031032)
0.0 0.1 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 0.1 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.8 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.4 1.5 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.2 1.1 GO:0045179 apical cortex(GO:0045179)
0.2 1.5 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 1.0 GO:0032426 stereocilium tip(GO:0032426)
0.1 1.7 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 0.7 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1 3.1 GO:0030673 axolemma(GO:0030673)
0.1 3.6 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 0.9 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 0.6 GO:0032300 mismatch repair complex(GO:0032300)
0.1 1.9 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 0.5 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.1 GO:0031251 PAN complex(GO:0031251)
0.0 2.2 GO:0030139 endocytic vesicle(GO:0030139)
0.0 1.9 GO:0036064 ciliary basal body(GO:0036064)
0.0 2.7 GO:0005769 early endosome(GO:0005769)
0.0 1.1 GO:0016605 PML body(GO:0016605)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.8 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.6 1.7 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.6 1.7 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.4 1.5 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.4 1.5 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.3 1.9 GO:0097001 ceramide binding(GO:0097001)
0.3 1.8 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.2 1.5 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.2 3.1 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.2 0.5 GO:0008502 melatonin receptor activity(GO:0008502)
0.1 0.6 GO:0019237 centromeric DNA binding(GO:0019237)
0.1 0.4 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.1 0.9 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 1.9 GO:0043422 protein kinase B binding(GO:0043422)
0.1 2.1 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 1.3 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.5 GO:0031957 fatty acid transporter activity(GO:0015245) very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 1.1 GO:0004697 protein kinase C activity(GO:0004697) phospholipase binding(GO:0043274)
0.0 0.4 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.6 GO:0004623 phospholipase A2 activity(GO:0004623)
0.0 0.7 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 1.5 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 0.7 GO:0005521 lamin binding(GO:0005521)
0.0 0.7 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 2.8 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 2.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.5 GO:0030276 clathrin binding(GO:0030276)
0.0 0.8 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.3 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 2.0 GO:0017124 SH3 domain binding(GO:0017124)
0.0 2.2 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 PID_GMCSF_PATHWAY GMCSF-mediated signaling events
0.0 2.1 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 1.1 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 3.3 PID_LKB1_PATHWAY LKB1 signaling events
0.0 0.7 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 1.8 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 2.2 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 1.1 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 0.5 PID_IFNG_PATHWAY IFN-gamma pathway
0.0 0.7 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.8 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.2 1.4 REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.1 3.1 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 2.2 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 0.7 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING Genes involved in Spry regulation of FGF signaling
0.1 1.1 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.5 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.9 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.7 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 1.7 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 1.2 REACTOME_MEIOSIS Genes involved in Meiosis
0.0 1.5 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression