Motif ID: Twist1
Z-value: 1.245

Transcription factors associated with Twist1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Twist1 | ENSMUSG00000035799.5 | Twist1 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Twist1 | mm10_v2_chr12_+_33957645_33957671 | 0.58 | 1.2e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.2 | 4.6 | GO:0051311 | spindle assembly involved in female meiosis(GO:0007056) meiotic metaphase plate congression(GO:0051311) |
1.1 | 3.2 | GO:0051892 | negative regulation of cardioblast differentiation(GO:0051892) dermatome development(GO:0061054) regulation of dermatome development(GO:0061183) negative regulation of dopaminergic neuron differentiation(GO:1904339) regulation of cardiac cell fate specification(GO:2000043) |
1.0 | 3.9 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
0.9 | 2.8 | GO:0072076 | hyaluranon cable assembly(GO:0036118) nephrogenic mesenchyme development(GO:0072076) negative regulation of glomerular mesangial cell proliferation(GO:0072125) negative regulation of glomerulus development(GO:0090194) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106) |
0.9 | 7.7 | GO:0042487 | regulation of odontogenesis of dentin-containing tooth(GO:0042487) |
0.8 | 2.3 | GO:0019405 | alditol catabolic process(GO:0019405) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166) |
0.5 | 1.6 | GO:0036388 | pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) DNA replication preinitiation complex assembly(GO:0071163) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299) |
0.5 | 1.6 | GO:0002302 | CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302) |
0.5 | 2.6 | GO:0031580 | membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580) |
0.5 | 1.5 | GO:0060023 | soft palate development(GO:0060023) |
0.5 | 1.5 | GO:0038145 | macrophage colony-stimulating factor signaling pathway(GO:0038145) regulation of interleukin-6-mediated signaling pathway(GO:0070103) negative regulation of interleukin-6-mediated signaling pathway(GO:0070104) |
0.4 | 1.2 | GO:0030070 | insulin processing(GO:0030070) |
0.4 | 3.4 | GO:0006104 | succinyl-CoA metabolic process(GO:0006104) |
0.4 | 2.1 | GO:0043569 | negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569) |
0.4 | 2.8 | GO:0046645 | positive regulation of gamma-delta T cell differentiation(GO:0045588) positive regulation of gamma-delta T cell activation(GO:0046645) positive regulation of uterine smooth muscle contraction(GO:0070474) |
0.3 | 1.6 | GO:0021508 | floor plate formation(GO:0021508) floor plate morphogenesis(GO:0033505) |
0.3 | 1.6 | GO:0060849 | regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849) |
0.3 | 0.9 | GO:1904395 | positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) |
0.3 | 2.0 | GO:1904217 | regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) regulation of serine C-palmitoyltransferase activity(GO:1904220) positive regulation of serine C-palmitoyltransferase activity(GO:1904222) |
0.3 | 0.9 | GO:2001160 | negative regulation of urine volume(GO:0035811) regulation of histone H3-K79 methylation(GO:2001160) |
0.3 | 0.8 | GO:2000564 | CD8-positive, alpha-beta T cell proliferation(GO:0035740) negative regulation of regulatory T cell differentiation(GO:0045590) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) |
0.3 | 0.8 | GO:0030200 | heparan sulfate proteoglycan catabolic process(GO:0030200) |
0.2 | 3.0 | GO:0070445 | oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445) |
0.2 | 1.5 | GO:0072697 | protein localization to cell cortex(GO:0072697) |
0.2 | 2.5 | GO:0018065 | protein-cofactor linkage(GO:0018065) |
0.2 | 0.5 | GO:0015712 | hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760) |
0.1 | 1.2 | GO:0090527 | actin filament reorganization(GO:0090527) |
0.1 | 0.7 | GO:0019230 | protein autoprocessing(GO:0016540) proprioception(GO:0019230) |
0.1 | 2.1 | GO:0042347 | negative regulation of NF-kappaB import into nucleus(GO:0042347) |
0.1 | 2.5 | GO:0048368 | lateral mesoderm development(GO:0048368) |
0.1 | 1.6 | GO:0050965 | detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965) |
0.1 | 0.7 | GO:0000050 | urea cycle(GO:0000050) urea metabolic process(GO:0019627) |
0.1 | 0.5 | GO:0002756 | MyD88-independent toll-like receptor signaling pathway(GO:0002756) |
0.1 | 2.3 | GO:0060445 | branching involved in salivary gland morphogenesis(GO:0060445) |
0.1 | 0.9 | GO:0090557 | establishment of endothelial intestinal barrier(GO:0090557) |
0.1 | 0.9 | GO:0001675 | acrosome assembly(GO:0001675) |
0.1 | 0.3 | GO:0061073 | ciliary body morphogenesis(GO:0061073) |
0.1 | 0.3 | GO:0035405 | histone-threonine phosphorylation(GO:0035405) positive regulation of B cell receptor signaling pathway(GO:0050861) |
0.1 | 2.4 | GO:1902476 | chloride transmembrane transport(GO:1902476) |
0.1 | 2.4 | GO:0048255 | mRNA stabilization(GO:0048255) |
0.0 | 0.3 | GO:0035754 | B cell chemotaxis(GO:0035754) |
0.0 | 0.5 | GO:2000580 | positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582) |
0.0 | 0.2 | GO:0045657 | positive regulation of monocyte differentiation(GO:0045657) |
0.0 | 0.4 | GO:0042594 | response to starvation(GO:0042594) |
0.0 | 0.3 | GO:0075522 | IRES-dependent viral translational initiation(GO:0075522) |
0.0 | 0.3 | GO:1902231 | positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231) |
0.0 | 0.4 | GO:0016188 | synaptic vesicle maturation(GO:0016188) |
0.0 | 0.9 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
0.0 | 0.8 | GO:0006783 | heme biosynthetic process(GO:0006783) |
0.0 | 0.6 | GO:0046856 | phosphatidylinositol dephosphorylation(GO:0046856) |
0.0 | 0.1 | GO:0051503 | adenine nucleotide transport(GO:0051503) |
0.0 | 0.8 | GO:0033209 | tumor necrosis factor-mediated signaling pathway(GO:0033209) |
0.0 | 0.3 | GO:0016180 | snRNA processing(GO:0016180) |
0.0 | 0.1 | GO:0044828 | negative regulation by host of viral genome replication(GO:0044828) |
0.0 | 0.5 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
0.0 | 0.1 | GO:0048386 | positive regulation of retinoic acid receptor signaling pathway(GO:0048386) |
0.0 | 0.6 | GO:0045600 | positive regulation of fat cell differentiation(GO:0045600) |
0.0 | 1.2 | GO:0009966 | regulation of signal transduction(GO:0009966) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.4 | 4.2 | GO:0030868 | smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425) |
1.0 | 3.0 | GO:1990851 | Wnt-Frizzled-LRP5/6 complex(GO:1990851) |
0.8 | 2.5 | GO:0071149 | TEAD-2-YAP complex(GO:0071149) |
0.6 | 3.4 | GO:0030062 | mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062) |
0.5 | 1.6 | GO:0036387 | nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387) |
0.5 | 2.1 | GO:0043293 | apoptosome(GO:0043293) |
0.5 | 4.6 | GO:0072687 | meiotic spindle(GO:0072687) |
0.2 | 0.7 | GO:0036488 | CHOP-C/EBP complex(GO:0036488) |
0.2 | 0.9 | GO:0043259 | laminin-10 complex(GO:0043259) |
0.2 | 1.2 | GO:0001520 | outer dense fiber(GO:0001520) |
0.1 | 2.8 | GO:0000242 | pericentriolar material(GO:0000242) |
0.1 | 0.4 | GO:1990590 | ATF1-ATF4 transcription factor complex(GO:1990590) |
0.1 | 0.9 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
0.1 | 1.2 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
0.1 | 1.0 | GO:0097542 | ciliary tip(GO:0097542) |
0.1 | 1.2 | GO:0031045 | dense core granule(GO:0031045) |
0.0 | 0.9 | GO:0002080 | acrosomal membrane(GO:0002080) |
0.0 | 0.4 | GO:0005916 | fascia adherens(GO:0005916) |
0.0 | 0.9 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
0.0 | 2.4 | GO:0005844 | polysome(GO:0005844) |
0.0 | 0.3 | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541) |
0.0 | 2.9 | GO:0043195 | terminal bouton(GO:0043195) |
0.0 | 1.5 | GO:0005581 | collagen trimer(GO:0005581) |
0.0 | 1.5 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
0.0 | 0.3 | GO:0032039 | integrator complex(GO:0032039) |
0.0 | 2.5 | GO:0000793 | condensed chromosome(GO:0000793) |
0.0 | 0.2 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
0.0 | 0.3 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
0.0 | 0.5 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
0.0 | 0.8 | GO:0005871 | kinesin complex(GO:0005871) |
0.0 | 0.1 | GO:0097470 | ribbon synapse(GO:0097470) |
0.0 | 5.4 | GO:0031012 | extracellular matrix(GO:0031012) |
0.0 | 0.6 | GO:0031902 | late endosome membrane(GO:0031902) |
0.0 | 2.6 | GO:0005759 | mitochondrial matrix(GO:0005759) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.1 | 3.4 | GO:0004774 | succinate-CoA ligase activity(GO:0004774) |
1.1 | 3.2 | GO:0005110 | frizzled-2 binding(GO:0005110) |
1.1 | 4.2 | GO:0072320 | volume-sensitive chloride channel activity(GO:0072320) |
0.6 | 2.8 | GO:0042610 | CD8 receptor binding(GO:0042610) |
0.5 | 1.5 | GO:0097677 | STAT family protein binding(GO:0097677) |
0.4 | 2.5 | GO:0004852 | uroporphyrinogen-III synthase activity(GO:0004852) |
0.3 | 2.6 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
0.3 | 2.8 | GO:0070700 | BMP receptor binding(GO:0070700) |
0.2 | 2.3 | GO:0016861 | intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861) |
0.2 | 0.6 | GO:0071936 | coreceptor activity involved in Wnt signaling pathway(GO:0071936) |
0.2 | 0.6 | GO:0034597 | phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597) |
0.2 | 1.4 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
0.2 | 2.4 | GO:0008484 | sulfuric ester hydrolase activity(GO:0008484) |
0.2 | 3.9 | GO:0003746 | translation elongation factor activity(GO:0003746) |
0.2 | 0.8 | GO:0047134 | protein-disulfide reductase activity(GO:0047134) |
0.2 | 1.2 | GO:0008889 | glycerophosphodiester phosphodiesterase activity(GO:0008889) |
0.1 | 2.0 | GO:0022889 | L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889) |
0.1 | 0.4 | GO:0004791 | thioredoxin-disulfide reductase activity(GO:0004791) |
0.1 | 0.7 | GO:0004322 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
0.1 | 2.5 | GO:0001134 | transcription factor activity, transcription factor recruiting(GO:0001134) |
0.1 | 1.6 | GO:0001972 | retinoic acid binding(GO:0001972) |
0.1 | 1.2 | GO:0004185 | serine-type carboxypeptidase activity(GO:0004185) |
0.1 | 1.6 | GO:0003688 | DNA replication origin binding(GO:0003688) |
0.1 | 2.6 | GO:0005109 | frizzled binding(GO:0005109) |
0.1 | 1.5 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
0.1 | 0.3 | GO:0003854 | 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854) |
0.1 | 2.4 | GO:0045182 | translation regulator activity(GO:0045182) |
0.1 | 1.5 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
0.0 | 0.3 | GO:0035184 | histone threonine kinase activity(GO:0035184) |
0.0 | 0.5 | GO:0050308 | sugar-phosphatase activity(GO:0050308) |
0.0 | 0.7 | GO:0001013 | RNA polymerase I regulatory region DNA binding(GO:0001013) |
0.0 | 0.8 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
0.0 | 0.1 | GO:0046964 | 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity(GO:0046964) |
0.0 | 1.2 | GO:0008307 | structural constituent of muscle(GO:0008307) |
0.0 | 0.4 | GO:0045294 | alpha-catenin binding(GO:0045294) |
0.0 | 1.6 | GO:0004879 | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531) |
0.0 | 1.6 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
0.0 | 0.5 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
0.0 | 0.3 | GO:0099602 | acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602) |
0.0 | 0.4 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
0.0 | 0.1 | GO:0016618 | hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267) |
0.0 | 4.6 | GO:0005525 | GTP binding(GO:0005525) |
0.0 | 0.8 | GO:0003777 | microtubule motor activity(GO:0003777) |
0.0 | 0.5 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 2.8 | PID_ALK2_PATHWAY | ALK2 signaling events |
0.1 | 3.9 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
0.1 | 0.9 | PID_INTEGRIN4_PATHWAY | Alpha6 beta4 integrin-ligand interactions |
0.1 | 4.6 | PID_AURORA_B_PATHWAY | Aurora B signaling |
0.1 | 2.8 | PID_NFKAPPAB_ATYPICAL_PATHWAY | Atypical NF-kappaB pathway |
0.1 | 1.6 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
0.1 | 0.9 | PID_INTEGRIN2_PATHWAY | Beta2 integrin cell surface interactions |
0.0 | 2.3 | PID_IFNG_PATHWAY | IFN-gamma pathway |
0.0 | 1.6 | PID_IL12_2PATHWAY | IL12-mediated signaling events |
0.0 | 1.5 | NABA_COLLAGENS | Genes encoding collagen proteins |
0.0 | 1.6 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
0.0 | 0.3 | PID_TCR_JNK_PATHWAY | JNK signaling in the CD4+ TCR pathway |
0.0 | 2.9 | WNT_SIGNALING | Genes related to Wnt-mediated signal transduction |
0.0 | 1.2 | PID_ARF6_TRAFFICKING_PATHWAY | Arf6 trafficking events |
0.0 | 0.7 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
0.0 | 0.7 | PID_HIF2PATHWAY | HIF-2-alpha transcription factor network |
0.0 | 0.4 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
0.0 | 1.9 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
0.0 | 0.4 | PID_NCADHERIN_PATHWAY | N-cadherin signaling events |
0.0 | 0.4 | ST_P38_MAPK_PATHWAY | p38 MAPK Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 2.8 | REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
0.2 | 1.6 | REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
0.2 | 3.4 | REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
0.1 | 1.5 | REACTOME_REGULATION_OF_IFNG_SIGNALING | Genes involved in Regulation of IFNG signaling |
0.1 | 2.5 | REACTOME_METABOLISM_OF_PORPHYRINS | Genes involved in Metabolism of porphyrins |
0.1 | 1.6 | REACTOME_UNWINDING_OF_DNA | Genes involved in Unwinding of DNA |
0.1 | 1.7 | REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY | Genes involved in Notch-HLH transcription pathway |
0.1 | 2.5 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
0.1 | 5.8 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
0.1 | 2.3 | REACTOME_GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
0.1 | 1.2 | REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING | Genes involved in Insulin Synthesis and Processing |
0.0 | 1.2 | REACTOME_STRIATED_MUSCLE_CONTRACTION | Genes involved in Striated Muscle Contraction |
0.0 | 0.9 | REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
0.0 | 0.8 | REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
0.0 | 0.3 | REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
0.0 | 0.3 | REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
0.0 | 0.9 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
0.0 | 0.8 | REACTOME_HS_GAG_DEGRADATION | Genes involved in HS-GAG degradation |
0.0 | 0.8 | REACTOME_KINESINS | Genes involved in Kinesins |
0.0 | 1.6 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
0.0 | 1.5 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
0.0 | 1.6 | REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
0.0 | 0.4 | REACTOME_SIGNALING_BY_BMP | Genes involved in Signaling by BMP |
0.0 | 0.7 | REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT | Genes involved in Mitochondrial Protein Import |
0.0 | 0.4 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
0.0 | 0.3 | REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
0.0 | 0.9 | REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS | Genes involved in Integrin cell surface interactions |
0.0 | 0.5 | REACTOME_GLUCOSE_TRANSPORT | Genes involved in Glucose transport |
0.0 | 0.4 | REACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION | Genes involved in Nuclear Events (kinase and transcription factor activation) |