Motif ID: Hoxc9

Z-value: 0.688


Transcription factors associated with Hoxc9:

Gene SymbolEntrez IDGene Name
Hoxc9 ENSMUSG00000036139.6 Hoxc9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hoxc9mm10_v2_chr15_+_102977032_102977032-0.262.9e-01Click!


Activity profile for motif Hoxc9.

activity profile for motif Hoxc9


Sorted Z-values histogram for motif Hoxc9

Sorted Z-values for motif Hoxc9



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxc9

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_35423582 2.348 ENSMUST00000154652.1
Cdon
cell adhesion molecule-related/down-regulated by oncogenes
chr18_+_65582239 1.770 ENSMUST00000182684.1
Zfp532
zinc finger protein 532
chr10_+_4710119 1.769 ENSMUST00000105588.1
ENSMUST00000105589.1
Esr1

estrogen receptor 1 (alpha)

chr2_-_26516620 1.621 ENSMUST00000132820.1
Notch1
notch 1
chrX_+_56609751 1.512 ENSMUST00000144068.1
Slc9a6
solute carrier family 9 (sodium/hydrogen exchanger), member 6
chr6_-_99044414 1.369 ENSMUST00000177507.1
ENSMUST00000123992.1
Foxp1

forkhead box P1

chr18_+_65582281 1.217 ENSMUST00000183319.1
Zfp532
zinc finger protein 532
chr4_+_100776664 1.110 ENSMUST00000030257.8
ENSMUST00000097955.2
Cachd1

cache domain containing 1

chrX_-_143933089 0.967 ENSMUST00000087313.3
Dcx
doublecortin
chr7_-_116038734 0.854 ENSMUST00000166877.1
Sox6
SRY-box containing gene 6
chr2_+_4300462 0.834 ENSMUST00000175669.1
Frmd4a
FERM domain containing 4A
chr2_-_84650714 0.793 ENSMUST00000111697.2
ENSMUST00000111670.2
ENSMUST00000111696.1
ENSMUST00000111678.1
ENSMUST00000111690.1
ENSMUST00000111695.1
ENSMUST00000111677.1
ENSMUST00000111698.1
ENSMUST00000099941.2
ENSMUST00000111676.1
ENSMUST00000111694.1
ENSMUST00000111675.1
ENSMUST00000111689.1
ENSMUST00000111687.1
ENSMUST00000111692.1
ENSMUST00000111685.1
ENSMUST00000111686.1
ENSMUST00000111688.1
ENSMUST00000111693.1
ENSMUST00000111684.1
Ctnnd1



















catenin (cadherin associated protein), delta 1



















chr18_+_65582390 0.763 ENSMUST00000169679.1
ENSMUST00000183326.1
Zfp532

zinc finger protein 532

chr2_-_84650760 0.698 ENSMUST00000111691.1
Ctnnd1
catenin (cadherin associated protein), delta 1
chr1_+_66321708 0.692 ENSMUST00000114013.1
Map2
microtubule-associated protein 2
chr6_-_119388671 0.667 ENSMUST00000169744.1
Adipor2
adiponectin receptor 2
chr2_-_84650490 0.666 ENSMUST00000066177.3
Ctnnd1
catenin (cadherin associated protein), delta 1
chr2_-_84650676 0.663 ENSMUST00000067232.3
Ctnnd1
catenin (cadherin associated protein), delta 1
chrX_-_141474034 0.631 ENSMUST00000101205.2
Col4a6
collagen, type IV, alpha 6
chr3_+_67892189 0.626 ENSMUST00000063263.3
Iqcj
IQ motif containing J
chr8_+_118283719 0.620 ENSMUST00000117160.1
Cdh13
cadherin 13
chr1_+_187997821 0.560 ENSMUST00000027906.6
Esrrg
estrogen-related receptor gamma
chr1_+_187997835 0.548 ENSMUST00000110938.1
Esrrg
estrogen-related receptor gamma
chr10_-_13324250 0.525 ENSMUST00000105543.1
Phactr2
phosphatase and actin regulator 2
chr8_-_120228221 0.499 ENSMUST00000183235.1
A330074K22Rik
RIKEN cDNA A330074K22 gene
chrX_+_56609843 0.471 ENSMUST00000077741.5
ENSMUST00000114784.2
Slc9a6

solute carrier family 9 (sodium/hydrogen exchanger), member 6

chr17_-_49564262 0.459 ENSMUST00000057610.6
Daam2
dishevelled associated activator of morphogenesis 2
chr11_+_85353156 0.412 ENSMUST00000108061.1
ENSMUST00000108062.1
ENSMUST00000108056.1
ENSMUST00000138423.1
ENSMUST00000074875.4
ENSMUST00000092821.3
Bcas3





breast carcinoma amplified sequence 3





chr4_-_150003130 0.398 ENSMUST00000084117.6
H6pd
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
chr10_-_13324160 0.393 ENSMUST00000105545.4
Phactr2
phosphatase and actin regulator 2
chr1_-_45503282 0.383 ENSMUST00000086430.4
Col5a2
collagen, type V, alpha 2
chr19_-_10880370 0.378 ENSMUST00000133303.1
Tmem109
transmembrane protein 109
chr5_+_67260696 0.336 ENSMUST00000161233.1
ENSMUST00000160352.1
Tmem33

transmembrane protein 33

chr10_-_88605017 0.323 ENSMUST00000119185.1
ENSMUST00000121629.1
Mybpc1

myosin binding protein C, slow-type

chr13_+_94083490 0.293 ENSMUST00000156071.1
Lhfpl2
lipoma HMGIC fusion partner-like 2
chr4_+_107830958 0.255 ENSMUST00000106731.2
Lrp8
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
chr5_-_44101668 0.233 ENSMUST00000087441.4
ENSMUST00000074113.6
Prom1

prominin 1

chr11_-_80080928 0.223 ENSMUST00000103233.3
ENSMUST00000061283.8
Crlf3

cytokine receptor-like factor 3

chr5_-_67427794 0.203 ENSMUST00000169190.1
Bend4
BEN domain containing 4
chr12_-_15816762 0.190 ENSMUST00000020922.7
Trib2
tribbles homolog 2 (Drosophila)
chr14_+_80000292 0.183 ENSMUST00000088735.3
Olfm4
olfactomedin 4
chr10_-_67912620 0.181 ENSMUST00000064656.7
Zfp365
zinc finger protein 365
chr11_+_3330401 0.175 ENSMUST00000045153.4
Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr8_+_54954728 0.172 ENSMUST00000033915.7
Gpm6a
glycoprotein m6a
chr6_+_54269135 0.162 ENSMUST00000114401.1
Chn2
chimerin (chimaerin) 2
chr4_+_137594140 0.154 ENSMUST00000105840.1
ENSMUST00000055131.6
ENSMUST00000105839.1
ENSMUST00000105838.1
Usp48



ubiquitin specific peptidase 48



chr4_-_91376433 0.121 ENSMUST00000107109.2
ENSMUST00000107111.2
ENSMUST00000107120.1
Elavl2


ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)


chrX_-_143933204 0.092 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
Dcx


doublecortin


chr4_-_109202217 0.087 ENSMUST00000160774.1
ENSMUST00000030288.7
ENSMUST00000162787.2
Osbpl9


oxysterol binding protein-like 9


chr5_+_67260565 0.086 ENSMUST00000037918.5
ENSMUST00000162543.1
Tmem33

transmembrane protein 33

chr11_-_94242701 0.084 ENSMUST00000061469.3
Wfikkn2
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
chr10_+_128411616 0.079 ENSMUST00000096386.5
ENSMUST00000171342.1
Rnf41

ring finger protein 41

chr1_+_58210397 0.073 ENSMUST00000040442.5
Aox4
aldehyde oxidase 4
chr3_+_66985700 0.062 ENSMUST00000046542.6
ENSMUST00000162693.1
Rsrc1

arginine/serine-rich coiled-coil 1

chr2_+_128967383 0.053 ENSMUST00000110320.2
ENSMUST00000110319.2
Zc3h6

zinc finger CCCH type containing 6

chr2_+_70474923 0.053 ENSMUST00000100043.2
Sp5
trans-acting transcription factor 5
chr3_+_66985680 0.038 ENSMUST00000065047.6
Rsrc1
arginine/serine-rich coiled-coil 1
chr16_-_37384915 0.024 ENSMUST00000114787.1
ENSMUST00000114782.1
ENSMUST00000023526.2
ENSMUST00000114775.1
Stxbp5l



syntaxin binding protein 5-like



chr9_+_53771499 0.016 ENSMUST00000048670.8
Slc35f2
solute carrier family 35, member F2
chr3_+_129199919 0.012 ENSMUST00000029657.9
ENSMUST00000106382.4
Pitx2

paired-like homeodomain transcription factor 2

chr9_-_7835255 0.001 ENSMUST00000074246.6
Birc2
baculoviral IAP repeat-containing 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.8 GO:0060690 epithelial cell differentiation involved in salivary gland development(GO:0060690)
0.5 1.6 GO:0003219 atrioventricular node development(GO:0003162) cardiac right ventricle formation(GO:0003219)
0.4 1.8 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.3 2.3 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.2 2.0 GO:0031547 brain-derived neurotrophic factor receptor signaling pathway(GO:0031547)
0.1 0.4 GO:1903896 positive regulation of IRE1-mediated unfolded protein response(GO:1903896)
0.1 1.4 GO:0061470 interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619)
0.1 0.4 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.1 0.6 GO:0055095 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096)
0.1 0.7 GO:0061042 vascular wound healing(GO:0061042)
0.1 0.2 GO:0072139 glomerular parietal epithelial cell differentiation(GO:0072139)
0.1 0.9 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.1 1.1 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 0.3 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.1 0.2 GO:0033566 gamma-tubulin complex localization(GO:0033566)
0.1 0.2 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0 0.6 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.0 0.3 GO:0038026 reelin-mediated signaling pathway(GO:0038026)
0.0 0.4 GO:0006098 pentose-phosphate shunt(GO:0006098)
0.0 0.1 GO:0046110 xanthine metabolic process(GO:0046110)
0.0 0.5 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 0.8 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.9 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 0.2 GO:0032693 negative regulation of interleukin-10 production(GO:0032693)
0.0 0.7 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.0 GO:0044308 axonal spine(GO:0044308)
0.3 1.6 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.3 2.8 GO:0005915 zonula adherens(GO:0005915)
0.3 1.8 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.1 0.4 GO:0005588 collagen type V trimer(GO:0005588)
0.1 0.6 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.1 0.2 GO:0071914 prominosome(GO:0071914)
0.1 0.7 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 0.3 GO:0005859 muscle myosin complex(GO:0005859)
0.0 0.4 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.4 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.2 GO:0042581 specific granule(GO:0042581)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.3 1.3 GO:0055100 adiponectin binding(GO:0055100)
0.2 2.0 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.1 0.4 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.1 0.4 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.1 0.7 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 0.3 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 0.3 GO:0038025 reelin receptor activity(GO:0038025)
0.1 0.2 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.1 1.1 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 1.6 GO:0005112 Notch binding(GO:0005112)
0.0 0.1 GO:0005128 erythropoietin receptor binding(GO:0005128)
0.0 0.4 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.1 GO:0030151 molybdenum ion binding(GO:0030151)
0.0 0.2 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.3 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 2.8 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.0 1.8 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling
0.0 1.6 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.3 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.8 NABA_COLLAGENS Genes encoding collagen proteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 2.3 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 1.8 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 0.3 REACTOME_PLATELET_SENSITIZATION_BY_LDL Genes involved in Platelet sensitization by LDL
0.0 1.7 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.8 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.3 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.7 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway