Motif ID: Isl1

Z-value: 0.351


Transcription factors associated with Isl1:

Gene SymbolEntrez IDGene Name
Isl1 ENSMUSG00000042258.7 Isl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Isl1mm10_v2_chr13_-_116309639_116309699-0.561.6e-02Click!


Activity profile for motif Isl1.

activity profile for motif Isl1


Sorted Z-values histogram for motif Isl1

Sorted Z-values for motif Isl1



Network of associatons between targets according to the STRING database.



First level regulatory network of Isl1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_37824580 0.481 ENSMUST00000063116.9
Msx1
msh homeobox 1
chr2_-_72986716 0.469 ENSMUST00000112062.1
Gm11084
predicted gene 11084
chr15_+_44196135 0.410 ENSMUST00000038856.6
ENSMUST00000110289.3
Trhr

thyrotropin releasing hormone receptor

chr14_-_12345847 0.360 ENSMUST00000022262.4
Fezf2
Fez family zinc finger 2
chr14_-_118052235 0.345 ENSMUST00000022725.2
Dct
dopachrome tautomerase
chr7_+_45017953 0.311 ENSMUST00000044111.7
Rras
Harvey rat sarcoma oncogene, subgroup R
chr1_+_12718496 0.300 ENSMUST00000088585.3
Sulf1
sulfatase 1
chr15_-_50889691 0.296 ENSMUST00000165201.2
ENSMUST00000184458.1
Trps1

trichorhinophalangeal syndrome I (human)

chr1_-_89933290 0.270 ENSMUST00000036954.7
Gbx2
gastrulation brain homeobox 2
chr2_-_169405435 0.250 ENSMUST00000131509.1
4930529I22Rik
RIKEN cDNA 4930529I22 gene
chr4_-_42661893 0.244 ENSMUST00000108006.3
Il11ra2
interleukin 11 receptor, alpha chain 2
chr19_+_55741810 0.235 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr7_-_25250720 0.221 ENSMUST00000116343.2
ENSMUST00000045847.8
Erf

Ets2 repressor factor

chr6_-_144209448 0.211 ENSMUST00000077160.5
Sox5
SRY-box containing gene 5
chr6_-_144209558 0.205 ENSMUST00000111749.1
ENSMUST00000170367.2
Sox5

SRY-box containing gene 5

chr6_-_144209471 0.203 ENSMUST00000038815.7
Sox5
SRY-box containing gene 5
chr14_+_13454010 0.191 ENSMUST00000112656.2
Synpr
synaptoporin
chrX_+_106920618 0.178 ENSMUST00000060576.7
Lpar4
lysophosphatidic acid receptor 4
chr3_-_150073620 0.177 ENSMUST00000057740.5
Rpsa-ps10
ribosomal protein SA, pseudogene 10
chr8_-_61902669 0.172 ENSMUST00000121785.1
ENSMUST00000034057.7
Palld

palladin, cytoskeletal associated protein

chr14_-_96519067 0.169 ENSMUST00000022666.7
Klhl1
kelch-like 1
chrX_+_56779437 0.169 ENSMUST00000114773.3
Fhl1
four and a half LIM domains 1
chr4_-_14621669 0.165 ENSMUST00000143105.1
Slc26a7
solute carrier family 26, member 7
chr8_-_71511762 0.161 ENSMUST00000048452.4
Plvap
plasmalemma vesicle associated protein
chr16_-_22161450 0.160 ENSMUST00000115379.1
Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr2_+_121456963 0.152 ENSMUST00000126764.1
Hypk
huntingtin interacting protein K
chr4_-_42168603 0.143 ENSMUST00000098121.3
Gm13305
predicted gene 13305
chr13_-_103764502 0.142 ENSMUST00000074616.5
Srek1
splicing regulatory glutamine/lysine-rich protein 1
chr3_-_88552859 0.139 ENSMUST00000119002.1
ENSMUST00000029698.8
Lamtor2

late endosomal/lysosomal adaptor, MAPK and MTOR activator 2

chr4_+_128654686 0.138 ENSMUST00000030588.6
ENSMUST00000136377.1
Phc2

polyhomeotic-like 2 (Drosophila)

chr19_+_55742242 0.137 ENSMUST00000111652.1
ENSMUST00000111649.1
ENSMUST00000111651.1
ENSMUST00000111653.1
ENSMUST00000111656.1
ENSMUST00000127233.1
ENSMUST00000153888.1
Tcf7l2






transcription factor 7 like 2, T cell specific, HMG box






chr14_+_13453937 0.137 ENSMUST00000153954.1
Synpr
synaptoporin
chr19_+_24875679 0.133 ENSMUST00000073080.5
Gm10053
predicted gene 10053
chr19_-_53371766 0.133 ENSMUST00000086887.1
Gm10197
predicted gene 10197
chr4_+_3940747 0.128 ENSMUST00000119403.1
Chchd7
coiled-coil-helix-coiled-coil-helix domain containing 7
chrX_+_96455359 0.126 ENSMUST00000033553.7
Heph
hephaestin
chr12_+_69963452 0.118 ENSMUST00000110560.1
Gm3086
predicted gene 3086
chr4_+_94739276 0.115 ENSMUST00000073939.6
ENSMUST00000102798.1
Tek

endothelial-specific receptor tyrosine kinase

chr17_-_35235755 0.115 ENSMUST00000048994.6
Nfkbil1
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor like 1
chr8_+_45507768 0.105 ENSMUST00000067065.7
ENSMUST00000098788.3
ENSMUST00000067107.7
ENSMUST00000171337.2
ENSMUST00000138049.1
ENSMUST00000141039.1
Sorbs2





sorbin and SH3 domain containing 2





chr4_-_14621805 0.103 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chr18_+_6332587 0.103 ENSMUST00000097682.2
Rpl27-ps3
ribosomal protein L27, pseudogene 3
chr7_-_118116128 0.101 ENSMUST00000128482.1
ENSMUST00000131840.1
Rps15a

ribosomal protein S15A

chr8_-_33747724 0.099 ENSMUST00000179364.1
Smim18
small integral membrane protein 18
chr7_-_118116171 0.097 ENSMUST00000131374.1
Rps15a
ribosomal protein S15A
chr19_+_55742056 0.094 ENSMUST00000111659.2
Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr19_+_55741884 0.091 ENSMUST00000111658.3
ENSMUST00000111654.1
Tcf7l2

transcription factor 7 like 2, T cell specific, HMG box

chr3_+_32736990 0.090 ENSMUST00000127477.1
ENSMUST00000121778.1
ENSMUST00000154257.1
Ndufb5


NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5


chr10_-_35711891 0.085 ENSMUST00000080898.2
Amd2
S-adenosylmethionine decarboxylase 2
chr7_+_51878967 0.079 ENSMUST00000051912.6
Gas2
growth arrest specific 2
chr2_-_127788854 0.077 ENSMUST00000028857.7
ENSMUST00000110357.1
Nphp1

nephronophthisis 1 (juvenile) homolog (human)

chr16_-_64786321 0.077 ENSMUST00000052588.4
Zfp654
zinc finger protein 654
chr4_-_41723129 0.075 ENSMUST00000171641.1
ENSMUST00000030158.4
Dctn3

dynactin 3

chr7_+_51879041 0.075 ENSMUST00000107591.2
Gas2
growth arrest specific 2
chr10_-_93081596 0.073 ENSMUST00000168617.1
ENSMUST00000168110.1
ENSMUST00000020200.7
Gm872


RIKEN cDNA 4930485B16 gene


chr7_+_141216626 0.068 ENSMUST00000141804.1
ENSMUST00000148975.1
Rassf7

Ras association (RalGDS/AF-6) domain family (N-terminal) member 7

chr4_+_154960915 0.067 ENSMUST00000049621.6
Hes5
hairy and enhancer of split 5 (Drosophila)
chr10_-_128176568 0.067 ENSMUST00000092033.2
Rbms2
RNA binding motif, single stranded interacting protein 2
chr2_-_152398046 0.064 ENSMUST00000063332.8
ENSMUST00000182625.1
Sox12

SRY-box containing gene 12

chrX_+_169879596 0.062 ENSMUST00000112105.1
ENSMUST00000078947.5
Mid1

midline 1

chr15_-_93519499 0.060 ENSMUST00000109255.2
Prickle1
prickle homolog 1 (Drosophila)
chr8_+_83666827 0.058 ENSMUST00000019608.5
Ptger1
prostaglandin E receptor 1 (subtype EP1)
chr13_+_76579670 0.058 ENSMUST00000126960.1
ENSMUST00000109583.2
Mctp1

multiple C2 domains, transmembrane 1

chr2_+_120476911 0.057 ENSMUST00000110716.1
ENSMUST00000028748.6
ENSMUST00000090028.5
ENSMUST00000110719.2
Capn3



calpain 3



chr15_-_50882806 0.055 ENSMUST00000184885.1
Trps1
trichorhinophalangeal syndrome I (human)
chr12_-_12941827 0.054 ENSMUST00000043396.7
Mycn
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
chr8_-_26119125 0.054 ENSMUST00000037182.7
Hook3
hook homolog 3 (Drosophila)
chr15_-_50890396 0.054 ENSMUST00000185183.1
Trps1
trichorhinophalangeal syndrome I (human)
chr4_-_14621494 0.053 ENSMUST00000149633.1
Slc26a7
solute carrier family 26, member 7
chr1_-_183147461 0.052 ENSMUST00000171366.1
Disp1
dispatched homolog 1 (Drosophila)
chr6_-_13871477 0.052 ENSMUST00000139231.1
2610001J05Rik
RIKEN cDNA 2610001J05 gene
chr18_-_6490808 0.052 ENSMUST00000028100.6
ENSMUST00000050542.5
Epc1

enhancer of polycomb homolog 1 (Drosophila)

chr17_+_46681038 0.051 ENSMUST00000002845.6
Mea1
male enhanced antigen 1
chr15_+_62037986 0.044 ENSMUST00000182956.1
ENSMUST00000182075.1
ENSMUST00000180432.2
ENSMUST00000181416.2
ENSMUST00000181657.2
Pvt1




plasmacytoma variant translocation 1




chr11_-_60913775 0.043 ENSMUST00000019075.3
Gm16515
predicted gene, Gm16515
chrX_+_114474312 0.042 ENSMUST00000113371.1
ENSMUST00000040504.5
Klhl4

kelch-like 4

chr4_-_120951664 0.040 ENSMUST00000106280.1
Zfp69
zinc finger protein 69
chr2_-_168955529 0.039 ENSMUST00000109162.2
Zfp64
zinc finger protein 64
chr5_-_103977360 0.036 ENSMUST00000048118.8
Hsd17b13
hydroxysteroid (17-beta) dehydrogenase 13
chr9_+_3404058 0.034 ENSMUST00000027027.5
Cwf19l2
CWF19-like 2, cell cycle control (S. pombe)
chr1_-_10038106 0.031 ENSMUST00000027050.3
Cops5
COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana)
chr3_-_25212720 0.030 ENSMUST00000091289.3
Gm10259
predicted pseudogene 10259
chr16_-_91069142 0.030 ENSMUST00000035689.1
ENSMUST00000114076.1
4932438H23Rik

RIKEN cDNA 4932438H23 gene

chr7_+_140763739 0.029 ENSMUST00000026552.7
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
chr9_-_95815389 0.029 ENSMUST00000119760.1
Pls1
plastin 1 (I-isoform)
chr17_-_24533709 0.026 ENSMUST00000061764.7
Rab26
RAB26, member RAS oncogene family
chr4_-_126325641 0.025 ENSMUST00000131113.1
Tekt2
tektin 2
chr3_-_104818539 0.025 ENSMUST00000106774.1
ENSMUST00000106775.1
ENSMUST00000166979.1
ENSMUST00000136148.1
Mov10



Moloney leukemia virus 10



chr12_-_73047179 0.024 ENSMUST00000050029.7
Six1
sine oculis-related homeobox 1
chr4_-_114987220 0.024 ENSMUST00000030491.8
Cmpk1
cytidine monophosphate (UMP-CMP) kinase 1
chr15_-_27630644 0.024 ENSMUST00000059662.7
Fam105b
family with sequence similarity 105, member B
chr10_-_13388753 0.024 ENSMUST00000105546.1
Phactr2
phosphatase and actin regulator 2
chr1_+_139422196 0.022 ENSMUST00000039867.7
Zbtb41
zinc finger and BTB domain containing 41 homolog
chr3_-_95754841 0.022 ENSMUST00000029752.8
ENSMUST00000074339.6
ENSMUST00000163530.1
ENSMUST00000098857.4
Tars2



threonyl-tRNA synthetase 2, mitochondrial (putative)



chr3_-_57294880 0.018 ENSMUST00000171384.1
Tm4sf1
transmembrane 4 superfamily member 1
chr12_-_113422730 0.015 ENSMUST00000177715.1
ENSMUST00000103426.1
Ighm

immunoglobulin heavy constant mu

chr3_+_10088173 0.015 ENSMUST00000061419.7
Gm9833
predicted gene 9833
chr1_+_132191436 0.014 ENSMUST00000112357.2
Lemd1
LEM domain containing 1
chr1_-_79440039 0.014 ENSMUST00000049972.4
Scg2
secretogranin II
chr3_+_88553716 0.013 ENSMUST00000008748.6
Ubqln4
ubiquilin 4
chrX_-_43274786 0.012 ENSMUST00000016294.7
Tenm1
teneurin transmembrane protein 1
chr19_+_8839298 0.009 ENSMUST00000160556.1
Bscl2
Bernardinelli-Seip congenital lipodystrophy 2 homolog (human)
chr14_+_124005355 0.008 ENSMUST00000166105.1
Gm17615
predicted gene, 17615
chr10_+_18469958 0.008 ENSMUST00000162891.1
ENSMUST00000100054.3
Nhsl1

NHS-like 1

chr16_-_4880284 0.007 ENSMUST00000037843.6
Ubald1
UBA-like domain containing 1
chr17_-_46680870 0.006 ENSMUST00000165007.1
ENSMUST00000071841.5
Klhdc3

kelch domain containing 3

chr14_-_70630149 0.006 ENSMUST00000022694.9
Dmtn
dematin actin binding protein
chr5_-_107875035 0.005 ENSMUST00000138111.1
ENSMUST00000112642.1
Evi5

ecotropic viral integration site 5

chrX_+_99975570 0.004 ENSMUST00000113779.1
ENSMUST00000113776.1
ENSMUST00000113775.1
ENSMUST00000113780.1
ENSMUST00000113778.1
ENSMUST00000113781.1
ENSMUST00000113783.1
ENSMUST00000071453.2
ENSMUST00000113777.1
Eda








ectodysplasin-A








chr14_-_62761112 0.004 ENSMUST00000053959.6
Ints6
integrator complex subunit 6
chr19_-_8839181 0.003 ENSMUST00000096259.4
Gng3
guanine nucleotide binding protein (G protein), gamma 3
chr13_+_63282142 0.002 ENSMUST00000159152.1
2010111I01Rik
RIKEN cDNA 2010111I01 gene
chr8_+_25720054 0.001 ENSMUST00000068916.8
ENSMUST00000139836.1
Ppapdc1b

phosphatidic acid phosphatase type 2 domain containing 1B


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.1 0.6 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.1 0.3 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 0.6 GO:0048625 myoblast fate commitment(GO:0048625)
0.1 0.4 GO:1904936 forebrain anterior/posterior pattern specification(GO:0021797) cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.1 0.3 GO:0006570 tyrosine metabolic process(GO:0006570)
0.0 0.3 GO:0019532 oxalate transport(GO:0019532)
0.0 0.3 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.0 0.2 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.0 0.1 GO:0048014 Tie signaling pathway(GO:0048014)
0.0 0.4 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.0 0.1 GO:0006597 spermine biosynthetic process(GO:0006597)
0.0 0.1 GO:1903348 positive regulation of bicellular tight junction assembly(GO:1903348)
0.0 0.1 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
0.0 0.1 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.0 0.1 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
0.0 0.4 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.0 0.2 GO:0002693 positive regulation of cellular extravasation(GO:0002693)
0.0 0.1 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.1 GO:0071986 Ragulator complex(GO:0071986)
0.0 0.3 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.3 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.1 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.3 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.0 0.6 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 0.3 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 0.2 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.1 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.1 GO:0019808 polyamine binding(GO:0019808)
0.0 0.1 GO:0004954 icosanoid receptor activity(GO:0004953) prostanoid receptor activity(GO:0004954) prostaglandin receptor activity(GO:0004955)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 PID_LPA4_PATHWAY LPA4-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.2 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.3 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion