Motif ID: Six3_Six1_Six2

Z-value: 0.822

Transcription factors associated with Six3_Six1_Six2:

Gene SymbolEntrez IDGene Name
Six1 ENSMUSG00000051367.8 Six1
Six2 ENSMUSG00000024134.10 Six2
Six3 ENSMUSG00000038805.9 Six3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Six3mm10_v2_chr17_+_85613432_85613608-0.351.6e-01Click!
Six1mm10_v2_chr12_-_73047179_730471790.223.7e-01Click!
Six2mm10_v2_chr17_-_85688252_856882750.204.4e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Six3_Six1_Six2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_142966709 2.791 ENSMUST00000041317.2
Ammecr1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr6_-_23248264 2.072 ENSMUST00000031709.5
Fezf1
Fez family zinc finger 1
chr9_+_98422961 1.979 ENSMUST00000052068.9
Rbp1
retinol binding protein 1, cellular
chr7_-_80115294 1.839 ENSMUST00000107384.3
Idh2
isocitrate dehydrogenase 2 (NADP+), mitochondrial
chr15_+_98571004 1.642 ENSMUST00000023728.6
4930415O20Rik
RIKEN cDNA 4930415O20 gene
chr10_-_128180265 1.589 ENSMUST00000099139.1
Rbms2
RNA binding motif, single stranded interacting protein 2
chr3_+_130068390 1.547 ENSMUST00000076703.6
Gm9396
predicted gene 9396
chr3_-_37724321 1.319 ENSMUST00000108105.1
ENSMUST00000079755.4
ENSMUST00000099128.1
Gm5148


predicted gene 5148


chr15_-_82244716 1.253 ENSMUST00000089155.4
ENSMUST00000089157.3
Cenpm

centromere protein M

chr7_+_30232310 1.024 ENSMUST00000108193.1
ENSMUST00000108192.1
Polr2i

polymerase (RNA) II (DNA directed) polypeptide I

chr8_-_4275886 0.988 ENSMUST00000003029.7
Timm44
translocase of inner mitochondrial membrane 44
chr18_+_56432116 0.981 ENSMUST00000070166.5
Gramd3
GRAM domain containing 3
chr2_+_106693185 0.961 ENSMUST00000111063.1
Mpped2
metallophosphoesterase domain containing 2
chr15_-_75894474 0.938 ENSMUST00000023237.6
Naprt1
nicotinate phosphoribosyltransferase domain containing 1
chr17_-_53539411 0.928 ENSMUST00000056198.3
Pp2d1
protein phosphatase 2C-like domain containing 1
chr7_+_30231884 0.916 ENSMUST00000019882.9
Polr2i
polymerase (RNA) II (DNA directed) polypeptide I
chrX_-_74373260 0.897 ENSMUST00000073067.4
ENSMUST00000037967.5
Slc10a3

solute carrier family 10 (sodium/bile acid cotransporter family), member 3

chr5_+_140607334 0.858 ENSMUST00000031555.1
Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr9_+_65141154 0.749 ENSMUST00000034961.4
Igdcc3
immunoglobulin superfamily, DCC subclass, member 3
chrX_+_169685191 0.719 ENSMUST00000112104.1
ENSMUST00000112107.1
Mid1

midline 1

chr8_-_106573461 0.628 ENSMUST00000073722.5
Gm10073
predicted pseudogene 10073
chr1_+_139454747 0.591 ENSMUST00000053364.8
ENSMUST00000097554.3
Aspm

asp (abnormal spindle)-like, microcephaly associated (Drosophila)

chr14_+_57798182 0.585 ENSMUST00000111269.1
Sap18
Sin3-associated polypeptide 18
chr7_+_43690418 0.573 ENSMUST00000056329.6
Klk14
kallikrein related-peptidase 14
chr6_+_38534823 0.550 ENSMUST00000019833.4
1110001J03Rik
RIKEN cDNA 1110001J03 gene
chr17_+_35241838 0.524 ENSMUST00000173731.1
Ddx39b
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr13_+_104229366 0.500 ENSMUST00000022227.6
Cenpk
centromere protein K
chr5_+_21543525 0.498 ENSMUST00000035651.4
Lrrc17
leucine rich repeat containing 17
chr7_-_126676357 0.471 ENSMUST00000106371.1
ENSMUST00000106372.3
ENSMUST00000155419.1
Sult1a1


sulfotransferase family 1A, phenol-preferring, member 1


chr8_+_84831522 0.467 ENSMUST00000036734.5
Gadd45gip1
growth arrest and DNA-damage-inducible, gamma interacting protein 1
chr7_-_101903783 0.466 ENSMUST00000106969.1
Tomt
transmembrane O-methyltransferase
chr8_+_69832633 0.454 ENSMUST00000131637.2
ENSMUST00000081503.6
Pbx4

pre B cell leukemia homeobox 4

chr3_+_88207308 0.447 ENSMUST00000180582.1
Gm3764
predicted gene 3764
chr4_-_43030440 0.428 ENSMUST00000135660.1
Stoml2
stomatin (Epb7.2)-like 2
chrX_-_74373218 0.400 ENSMUST00000178691.1
ENSMUST00000114146.1
Ubl4
Slc10a3
ubiquitin-like 4
solute carrier family 10 (sodium/bile acid cotransporter family), member 3
chr17_+_56717759 0.383 ENSMUST00000002452.6
Ndufa11
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 11
chr17_+_35241746 0.379 ENSMUST00000068056.5
ENSMUST00000174757.1
Ddx39b

DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B

chr12_+_84773262 0.328 ENSMUST00000021667.5
Isca2
iron-sulfur cluster assembly 2 homolog (S. cerevisiae)
chr3_+_146220955 0.318 ENSMUST00000039164.2
Lpar3
lysophosphatidic acid receptor 3
chr14_+_58893465 0.313 ENSMUST00000079960.1
Rpl13-ps3
ribosomal protein L13, pseudogene 3
chr6_-_115675871 0.291 ENSMUST00000112949.1
Raf1
v-raf-leukemia viral oncogene 1
chr7_-_126676428 0.278 ENSMUST00000106373.1
Sult1a1
sulfotransferase family 1A, phenol-preferring, member 1
chr10_+_24595623 0.269 ENSMUST00000176228.1
ENSMUST00000129142.1
Ctgf

connective tissue growth factor

chr19_-_55315980 0.262 ENSMUST00000076891.5
Zdhhc6
zinc finger, DHHC domain containing 6
chrY_-_6237995 0.262 ENSMUST00000177612.1
Gm21746
predicted gene, 21746
chr9_+_104002546 0.242 ENSMUST00000035167.8
ENSMUST00000117054.1
Nphp3

nephronophthisis 3 (adolescent)

chr17_+_40811089 0.229 ENSMUST00000024721.7
Rhag
Rhesus blood group-associated A glycoprotein
chr19_-_23075853 0.226 ENSMUST00000181623.1
C330002G04Rik
RIKEN cDNA C330002G04 gene
chr9_-_121839460 0.225 ENSMUST00000135986.2
Ccdc13
coiled-coil domain containing 13
chr11_-_99230998 0.218 ENSMUST00000103133.3
Smarce1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
chr16_-_11203259 0.213 ENSMUST00000119953.1
Rsl1d1
ribosomal L1 domain containing 1
chr5_+_104046869 0.195 ENSMUST00000031250.7
Nudt9
nudix (nucleoside diphosphate linked moiety X)-type motif 9
chr17_-_36951636 0.189 ENSMUST00000040402.7
ENSMUST00000174711.1
Ppp1r11

protein phosphatase 1, regulatory (inhibitor) subunit 11

chr2_+_117249725 0.188 ENSMUST00000028825.4
Fam98b
family with sequence similarity 98, member B
chr8_-_22653406 0.186 ENSMUST00000033938.5
Polb
polymerase (DNA directed), beta
chr14_+_57798156 0.176 ENSMUST00000128764.1
Sap18
Sin3-associated polypeptide 18
chr7_-_141168671 0.167 ENSMUST00000106033.3
Rnh1
ribonuclease/angiogenin inhibitor 1
chr1_+_136467958 0.162 ENSMUST00000047817.6
Kif14
kinesin family member 14
chr4_+_134864536 0.156 ENSMUST00000030627.7
Rhd
Rh blood group, D antigen
chr11_-_69695521 0.143 ENSMUST00000181261.1
Tnfsf12
tumor necrosis factor (ligand) superfamily, member 12
chr12_+_30584429 0.142 ENSMUST00000057151.8
Tmem18
transmembrane protein 18
chr10_-_78487842 0.135 ENSMUST00000069431.4
Gm9978
predicted gene 9978
chr2_+_131491764 0.134 ENSMUST00000028806.5
ENSMUST00000110179.2
ENSMUST00000110189.2
ENSMUST00000110182.2
ENSMUST00000110183.2
ENSMUST00000110186.2
ENSMUST00000110188.1
Smox






spermine oxidase






chr19_+_8764934 0.129 ENSMUST00000184663.1
Nxf1
nuclear RNA export factor 1
chr10_+_100488289 0.123 ENSMUST00000164751.1
Cep290
centrosomal protein 290
chr1_-_119504736 0.109 ENSMUST00000004565.8
Ralb
v-ral simian leukemia viral oncogene homolog B (ras related)
chr7_-_30232186 0.099 ENSMUST00000006254.5
Tbcb
tubulin folding cofactor B
chr9_+_72958785 0.089 ENSMUST00000098567.2
ENSMUST00000034734.8
Dyx1c1

dyslexia susceptibility 1 candidate 1 homolog (human)

chr4_+_11758147 0.087 ENSMUST00000029871.5
ENSMUST00000108303.1
Cdh17

cadherin 17

chr15_-_76206309 0.082 ENSMUST00000073418.6
ENSMUST00000171634.1
ENSMUST00000076442.5
Plec


plectin


chr5_-_62765618 0.068 ENSMUST00000159470.1
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr15_+_38661904 0.063 ENSMUST00000022904.6
Atp6v1c1
ATPase, H+ transporting, lysosomal V1 subunit C1
chr4_-_116651644 0.049 ENSMUST00000030455.8
Akr1a1
aldo-keto reductase family 1, member A1 (aldehyde reductase)
chr16_+_11203375 0.034 ENSMUST00000181526.1
2610020C07Rik
RIKEN cDNA 2610020C07 gene
chr9_+_119341487 0.021 ENSMUST00000175743.1
ENSMUST00000176397.1
Acaa1a

acetyl-Coenzyme A acyltransferase 1A

chr9_-_36797303 0.002 ENSMUST00000115086.5
Ei24
etoposide induced 2.4 mRNA

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:0001193 maintenance of transcriptional fidelity during DNA-templated transcription elongation(GO:0001192) maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter(GO:0001193)
0.6 1.8 GO:0006097 glyoxylate cycle(GO:0006097) negative regulation of glial cell migration(GO:1903976)
0.5 2.0 GO:0006776 vitamin A metabolic process(GO:0006776)
0.3 2.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.2 0.9 GO:0007386 compartment pattern specification(GO:0007386)
0.1 0.4 GO:1990046 positive regulation of mitochondrial DNA replication(GO:0090297) regulation of cardiolipin metabolic process(GO:1900208) positive regulation of cardiolipin metabolic process(GO:1900210) stress-induced mitochondrial fusion(GO:1990046)
0.1 0.9 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.1 0.4 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.1 0.6 GO:0051661 maintenance of centrosome location(GO:0051661)
0.1 0.5 GO:0048539 bone marrow development(GO:0048539)
0.1 0.3 GO:0071550 death-inducing signaling complex assembly(GO:0071550)
0.1 0.5 GO:0019614 catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
0.1 0.6 GO:0007320 insemination(GO:0007320)
0.1 0.2 GO:0048496 maintenance of organ identity(GO:0048496)
0.1 0.7 GO:0035372 protein localization to microtubule(GO:0035372)
0.1 0.7 GO:0051923 sulfation(GO:0051923)
0.1 0.3 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.1 0.2 GO:0046032 ADP catabolic process(GO:0046032)
0.1 0.2 GO:0071707 immunoglobulin heavy chain V-D-J recombination(GO:0071707)
0.1 1.0 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 0.2 GO:0021698 cerebellar cortex structural organization(GO:0021698)
0.0 0.3 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.5 GO:1903862 positive regulation of oxidative phosphorylation(GO:1903862)
0.0 0.1 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.0 0.1 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.0 0.1 GO:0046208 spermine catabolic process(GO:0046208)
0.0 0.3 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 0.1 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 1.3 GO:0032526 response to retinoic acid(GO:0032526)
0.0 0.2 GO:0006337 nucleosome disassembly(GO:0006337)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0036449 microtubule minus-end(GO:0036449)
0.1 1.9 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 0.8 GO:0061574 ASAP complex(GO:0061574)
0.1 0.9 GO:0005688 U6 snRNP(GO:0005688)
0.1 0.2 GO:0097543 ciliary inversin compartment(GO:0097543)
0.1 0.2 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.0 0.4 GO:0042101 T cell receptor complex(GO:0042101)
0.0 1.7 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.9 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.3 GO:0031143 pseudopodium(GO:0031143)
0.0 0.5 GO:0001741 XY body(GO:0001741)
0.0 0.2 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 0.2 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.2 GO:0071564 npBAF complex(GO:0071564)
0.0 0.1 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 1.8 GO:0000776 kinetochore(GO:0000776)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.3 2.0 GO:0019841 retinol binding(GO:0019841)
0.3 1.3 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.3 0.9 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.2 0.7 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.2 0.9 GO:0030621 U4 snRNA binding(GO:0030621)
0.2 0.5 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.1 0.4 GO:1901612 phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)
0.0 0.3 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.1 GO:0046592 polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)
0.0 1.9 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.0 0.1 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.0 0.2 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.0 0.2 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.4 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.0 0.2 GO:0008428 ribonuclease inhibitor activity(GO:0008428)
0.0 0.9 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.3 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.3 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.3 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 2.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.0 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.3 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.2 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.7 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.1 0.7 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 1.8 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.9 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 1.0 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.3 REACTOME_RAF_MAP_KINASE_CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.2 REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 1.8 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.2 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters