Motif ID: Six6
Z-value: 0.525

Transcription factors associated with Six6:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Six6 | ENSMUSG00000021099.5 | Six6 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Six6 | mm10_v2_chr12_+_72939724_72939758 | -0.15 | 5.7e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 2.4 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
0.4 | 1.1 | GO:0033088 | negative regulation of immature T cell proliferation in thymus(GO:0033088) |
0.3 | 1.4 | GO:0006776 | vitamin A metabolic process(GO:0006776) |
0.3 | 0.8 | GO:0001193 | maintenance of transcriptional fidelity during DNA-templated transcription elongation(GO:0001192) maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter(GO:0001193) |
0.3 | 1.3 | GO:0007386 | compartment pattern specification(GO:0007386) |
0.2 | 1.0 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
0.2 | 1.0 | GO:0019659 | fermentation(GO:0006113) lactate biosynthetic process from pyruvate(GO:0019244) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661) |
0.2 | 0.5 | GO:0060392 | negative regulation of SMAD protein import into nucleus(GO:0060392) |
0.1 | 0.6 | GO:0014005 | microglia differentiation(GO:0014004) microglia development(GO:0014005) |
0.1 | 0.4 | GO:1904975 | response to bleomycin(GO:1904975) cellular response to bleomycin(GO:1904976) |
0.1 | 0.4 | GO:1903644 | regulation of chaperone-mediated protein folding(GO:1903644) |
0.1 | 0.4 | GO:0072488 | ammonium transmembrane transport(GO:0072488) |
0.1 | 0.4 | GO:0046032 | ADP catabolic process(GO:0046032) |
0.1 | 1.9 | GO:0035563 | positive regulation of chromatin binding(GO:0035563) |
0.1 | 0.5 | GO:0019614 | catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424) |
0.1 | 0.5 | GO:0048539 | bone marrow development(GO:0048539) |
0.1 | 0.9 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
0.1 | 0.3 | GO:0002188 | translation reinitiation(GO:0002188) |
0.1 | 0.6 | GO:0070236 | positive regulation of immunoglobulin secretion(GO:0051024) negative regulation of activation-induced cell death of T cells(GO:0070236) |
0.1 | 0.6 | GO:0071372 | cellular response to follicle-stimulating hormone stimulus(GO:0071372) |
0.1 | 0.3 | GO:0075525 | viral translational termination-reinitiation(GO:0075525) |
0.1 | 0.7 | GO:1903862 | positive regulation of oxidative phosphorylation(GO:1903862) |
0.1 | 0.4 | GO:0071474 | cellular hyperosmotic response(GO:0071474) |
0.1 | 0.2 | GO:0030647 | polyketide metabolic process(GO:0030638) aminoglycoside antibiotic metabolic process(GO:0030647) daunorubicin metabolic process(GO:0044597) doxorubicin metabolic process(GO:0044598) |
0.1 | 0.2 | GO:0070318 | positive regulation of G0 to G1 transition(GO:0070318) |
0.1 | 0.4 | GO:0007320 | insemination(GO:0007320) |
0.0 | 0.2 | GO:0046208 | spermine catabolic process(GO:0046208) |
0.0 | 0.3 | GO:0097428 | protein maturation by iron-sulfur cluster transfer(GO:0097428) |
0.0 | 0.1 | GO:0071550 | death-inducing signaling complex assembly(GO:0071550) |
0.0 | 0.3 | GO:2000002 | negative regulation of DNA damage checkpoint(GO:2000002) |
0.0 | 0.2 | GO:0007089 | traversing start control point of mitotic cell cycle(GO:0007089) |
0.0 | 0.6 | GO:0061158 | 3'-UTR-mediated mRNA destabilization(GO:0061158) |
0.0 | 0.2 | GO:0042364 | L-ascorbic acid metabolic process(GO:0019852) water-soluble vitamin biosynthetic process(GO:0042364) |
0.0 | 0.6 | GO:0006337 | nucleosome disassembly(GO:0006337) |
0.0 | 0.1 | GO:0060032 | notochord regression(GO:0060032) |
0.0 | 0.5 | GO:0009048 | dosage compensation by inactivation of X chromosome(GO:0009048) |
0.0 | 0.3 | GO:0035372 | protein localization to microtubule(GO:0035372) |
0.0 | 0.3 | GO:0032836 | glomerular basement membrane development(GO:0032836) |
0.0 | 0.9 | GO:0018345 | protein palmitoylation(GO:0018345) |
0.0 | 0.3 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
0.0 | 0.2 | GO:0002339 | B cell selection(GO:0002339) |
0.0 | 0.4 | GO:1901673 | regulation of mitotic spindle assembly(GO:1901673) |
0.0 | 0.5 | GO:0015701 | bicarbonate transport(GO:0015701) |
0.0 | 0.2 | GO:0006370 | 7-methylguanosine mRNA capping(GO:0006370) |
0.0 | 0.8 | GO:0070584 | mitochondrion morphogenesis(GO:0070584) |
0.0 | 0.2 | GO:0006729 | tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146) |
0.0 | 0.2 | GO:0015074 | DNA integration(GO:0015074) |
0.0 | 0.1 | GO:0002314 | germinal center B cell differentiation(GO:0002314) |
0.0 | 0.3 | GO:0043923 | positive regulation by host of viral transcription(GO:0043923) |
0.0 | 0.3 | GO:0045954 | positive regulation of natural killer cell mediated immunity(GO:0002717) positive regulation of natural killer cell mediated cytotoxicity(GO:0045954) |
0.0 | 0.3 | GO:0030150 | protein import into mitochondrial matrix(GO:0030150) |
0.0 | 1.4 | GO:0007338 | single fertilization(GO:0007338) |
0.0 | 0.3 | GO:0033194 | response to hydroperoxide(GO:0033194) |
0.0 | 0.3 | GO:0016973 | poly(A)+ mRNA export from nucleus(GO:0016973) |
0.0 | 0.2 | GO:0043928 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928) |
0.0 | 0.4 | GO:0006406 | mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 1.1 | GO:0043219 | lateral loop(GO:0043219) |
0.1 | 1.0 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
0.1 | 0.2 | GO:0031533 | mRNA cap methyltransferase complex(GO:0031533) |
0.1 | 0.6 | GO:0030915 | Smc5-Smc6 complex(GO:0030915) |
0.1 | 1.0 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
0.1 | 0.2 | GO:0097057 | TRAF2-GSTP1 complex(GO:0097057) |
0.1 | 0.2 | GO:0032311 | angiogenin-PRI complex(GO:0032311) |
0.1 | 0.6 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
0.0 | 0.8 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
0.0 | 0.4 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
0.0 | 0.4 | GO:0000815 | ESCRT III complex(GO:0000815) |
0.0 | 0.2 | GO:0019815 | B cell receptor complex(GO:0019815) |
0.0 | 0.2 | GO:0097504 | Gemini of coiled bodies(GO:0097504) |
0.0 | 0.6 | GO:0016514 | SWI/SNF complex(GO:0016514) |
0.0 | 0.3 | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541) |
0.0 | 0.3 | GO:0005688 | U6 snRNP(GO:0005688) |
0.0 | 0.3 | GO:0072669 | tRNA-splicing ligase complex(GO:0072669) |
0.0 | 0.6 | GO:0008305 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
0.0 | 0.6 | GO:0001741 | XY body(GO:0001741) |
0.0 | 0.2 | GO:0030015 | CCR4-NOT core complex(GO:0030015) |
0.0 | 0.3 | GO:0042405 | nuclear inclusion body(GO:0042405) |
0.0 | 1.0 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
0.0 | 0.3 | GO:0042555 | MCM complex(GO:0042555) |
0.0 | 0.3 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
0.0 | 0.2 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
0.0 | 0.7 | GO:0055038 | recycling endosome membrane(GO:0055038) |
0.0 | 0.7 | GO:0005669 | transcription factor TFIID complex(GO:0005669) |
0.0 | 0.9 | GO:0016459 | myosin complex(GO:0016459) |
0.0 | 0.6 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
0.0 | 1.1 | GO:0000313 | organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761) |
0.0 | 0.1 | GO:0097542 | ciliary tip(GO:0097542) |
0.0 | 0.5 | GO:0005801 | cis-Golgi network(GO:0005801) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 1.3 | GO:0033829 | O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829) |
0.4 | 1.1 | GO:0001042 | RNA polymerase I core binding(GO:0001042) |
0.2 | 1.0 | GO:0004459 | L-lactate dehydrogenase activity(GO:0004459) |
0.2 | 1.4 | GO:0019841 | retinol binding(GO:0019841) |
0.2 | 0.8 | GO:0008508 | bile acid:sodium symporter activity(GO:0008508) |
0.2 | 0.5 | GO:0016206 | catechol O-methyltransferase activity(GO:0016206) |
0.2 | 0.9 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
0.1 | 0.6 | GO:0001851 | complement component C3b binding(GO:0001851) |
0.1 | 0.4 | GO:0010698 | acetyltransferase activator activity(GO:0010698) |
0.1 | 0.4 | GO:0031727 | CCR2 chemokine receptor binding(GO:0031727) |
0.1 | 0.2 | GO:0004482 | mRNA (guanine-N7-)-methyltransferase activity(GO:0004482) |
0.1 | 0.2 | GO:0046592 | polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901) |
0.1 | 0.6 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
0.1 | 1.0 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
0.1 | 0.3 | GO:0030621 | U4 snRNA binding(GO:0030621) |
0.1 | 0.2 | GO:0004127 | cytidylate kinase activity(GO:0004127) |
0.0 | 0.6 | GO:0005167 | neurotrophin TRK receptor binding(GO:0005167) |
0.0 | 0.4 | GO:0047631 | ADP-ribose diphosphatase activity(GO:0047631) |
0.0 | 0.2 | GO:0004032 | alditol:NADP+ 1-oxidoreductase activity(GO:0004032) |
0.0 | 0.3 | GO:1990932 | 5.8S rRNA binding(GO:1990932) |
0.0 | 0.6 | GO:0035198 | miRNA binding(GO:0035198) |
0.0 | 0.9 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
0.0 | 0.2 | GO:0004142 | diacylglycerol cholinephosphotransferase activity(GO:0004142) |
0.0 | 0.2 | GO:0048038 | quinone binding(GO:0048038) |
0.0 | 0.5 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
0.0 | 1.2 | GO:0051539 | 4 iron, 4 sulfur cluster binding(GO:0051539) |
0.0 | 0.3 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
0.0 | 0.4 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
0.0 | 0.1 | GO:0033883 | pyridoxal phosphatase activity(GO:0033883) |
0.0 | 0.4 | GO:0008519 | ammonium transmembrane transporter activity(GO:0008519) |
0.0 | 0.1 | GO:0035673 | oligopeptide transmembrane transporter activity(GO:0035673) |
0.0 | 0.5 | GO:0001222 | transcription corepressor binding(GO:0001222) |
0.0 | 0.2 | GO:0008428 | ribonuclease inhibitor activity(GO:0008428) |
0.0 | 0.8 | GO:0003899 | DNA-directed RNA polymerase activity(GO:0003899) |
0.0 | 1.1 | GO:0003743 | translation initiation factor activity(GO:0003743) |
0.0 | 0.3 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
0.0 | 0.2 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
0.0 | 0.6 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
0.0 | 0.1 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
0.0 | 0.0 | GO:0030171 | voltage-gated proton channel activity(GO:0030171) |
0.0 | 0.2 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
0.0 | 0.2 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 1.1 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
0.0 | 0.6 | PID_INTEGRIN2_PATHWAY | Beta2 integrin cell surface interactions |
0.0 | 0.3 | PID_ERB_GENOMIC_PATHWAY | Validated nuclear estrogen receptor beta network |
0.0 | 1.4 | PID_RETINOIC_ACID_PATHWAY | Retinoic acid receptors-mediated signaling |
0.0 | 0.4 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
0.0 | 1.0 | NABA_COLLAGENS | Genes encoding collagen proteins |
0.0 | 0.6 | PID_AMB2_NEUTROPHILS_PATHWAY | amb2 Integrin signaling |
0.0 | 0.4 | ST_GA12_PATHWAY | G alpha 12 Pathway |
0.0 | 0.6 | PID_CD8_TCR_DOWNSTREAM_PATHWAY | Downstream signaling in naïve CD8+ T cells |
0.0 | 0.6 | PID_EPHB_FWD_PATHWAY | EPHB forward signaling |
0.0 | 0.8 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 0.6 | REACTOME_ENDOGENOUS_STEROLS | Genes involved in Endogenous sterols |
0.1 | 1.3 | REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
0.1 | 0.3 | REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |
0.0 | 0.8 | REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
0.0 | 1.3 | REACTOME_GRB2_EVENTS_IN_ERBB2_SIGNALING | Genes involved in GRB2 events in ERBB2 signaling |
0.0 | 1.0 | REACTOME_PYRUVATE_METABOLISM | Genes involved in Pyruvate metabolism |
0.0 | 0.3 | REACTOME_CD28_DEPENDENT_VAV1_PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
0.0 | 0.5 | REACTOME_REGULATION_OF_KIT_SIGNALING | Genes involved in Regulation of KIT signaling |
0.0 | 0.7 | REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
0.0 | 0.9 | REACTOME_GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
0.0 | 1.0 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
0.0 | 0.3 | REACTOME_UNWINDING_OF_DNA | Genes involved in Unwinding of DNA |
0.0 | 0.7 | REACTOME_TRANSPORT_OF_MATURE_MRNA_DERIVED_FROM_AN_INTRONLESS_TRANSCRIPT | Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript |
0.0 | 0.2 | REACTOME_METABOLISM_OF_POLYAMINES | Genes involved in Metabolism of polyamines |
0.0 | 1.0 | REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL | Genes involved in Cell surface interactions at the vascular wall |
0.0 | 0.4 | REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
0.0 | 0.2 | REACTOME_SYNTHESIS_OF_PE | Genes involved in Synthesis of PE |
0.0 | 0.2 | REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
0.0 | 0.2 | REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |