Motif ID: Nr1h4
Z-value: 0.706

Transcription factors associated with Nr1h4:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Nr1h4 | ENSMUSG00000047638.9 | Nr1h4 |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 2.2 | GO:0007021 | tubulin complex assembly(GO:0007021) |
0.3 | 1.0 | GO:1904049 | negative regulation of spontaneous neurotransmitter secretion(GO:1904049) |
0.2 | 0.9 | GO:0051933 | amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935) |
0.2 | 0.8 | GO:0033540 | fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540) |
0.2 | 0.8 | GO:0060745 | mammary gland branching involved in pregnancy(GO:0060745) |
0.2 | 0.7 | GO:1901491 | negative regulation of lymphangiogenesis(GO:1901491) |
0.2 | 0.5 | GO:0006657 | CDP-choline pathway(GO:0006657) |
0.1 | 0.7 | GO:0015871 | choline transport(GO:0015871) |
0.1 | 0.4 | GO:0050713 | negative regulation of interleukin-1 beta secretion(GO:0050713) |
0.1 | 1.0 | GO:0010968 | regulation of microtubule nucleation(GO:0010968) |
0.1 | 0.4 | GO:0019074 | viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074) |
0.1 | 0.4 | GO:0071929 | alpha-tubulin acetylation(GO:0071929) |
0.1 | 0.9 | GO:0007296 | vitellogenesis(GO:0007296) |
0.1 | 0.4 | GO:0019355 | nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process(GO:0034627) 'de novo' NAD biosynthetic process from aspartate(GO:0034628) |
0.1 | 0.5 | GO:1902774 | late endosome to lysosome transport(GO:1902774) |
0.1 | 0.5 | GO:1903012 | positive regulation of bone development(GO:1903012) |
0.1 | 0.3 | GO:1903527 | positive regulation of membrane tubulation(GO:1903527) |
0.1 | 0.5 | GO:0071955 | recycling endosome to Golgi transport(GO:0071955) |
0.1 | 0.5 | GO:0006172 | ADP biosynthetic process(GO:0006172) |
0.1 | 0.3 | GO:1900740 | regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740) |
0.1 | 0.5 | GO:0015879 | carnitine transport(GO:0015879) |
0.1 | 0.2 | GO:0070375 | ERK5 cascade(GO:0070375) |
0.1 | 0.6 | GO:1900364 | negative regulation of mRNA polyadenylation(GO:1900364) positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
0.1 | 0.4 | GO:0046880 | regulation of follicle-stimulating hormone secretion(GO:0046880) follicle-stimulating hormone secretion(GO:0046884) |
0.1 | 0.3 | GO:0036438 | maintenance of lens transparency(GO:0036438) |
0.1 | 0.3 | GO:0014874 | response to stimulus involved in regulation of muscle adaptation(GO:0014874) |
0.1 | 0.2 | GO:1903903 | regulation of establishment of T cell polarity(GO:1903903) |
0.1 | 0.3 | GO:2001025 | positive regulation of response to drug(GO:2001025) |
0.1 | 0.3 | GO:2000483 | negative regulation of interleukin-8 secretion(GO:2000483) |
0.0 | 0.2 | GO:1903546 | negative regulation of appetite by leptin-mediated signaling pathway(GO:0038108) protein localization to photoreceptor outer segment(GO:1903546) |
0.0 | 0.4 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
0.0 | 2.1 | GO:0045668 | negative regulation of osteoblast differentiation(GO:0045668) |
0.0 | 0.3 | GO:0071397 | cellular response to cholesterol(GO:0071397) |
0.0 | 0.2 | GO:2000825 | positive regulation of androgen receptor activity(GO:2000825) |
0.0 | 0.2 | GO:0048597 | post-embryonic camera-type eye morphogenesis(GO:0048597) |
0.0 | 0.1 | GO:0018214 | peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214) |
0.0 | 0.1 | GO:0098706 | ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706) negative regulation of vacuolar transport(GO:1903336) |
0.0 | 0.3 | GO:0015721 | bile acid and bile salt transport(GO:0015721) |
0.0 | 0.3 | GO:0014052 | regulation of gamma-aminobutyric acid secretion(GO:0014052) |
0.0 | 0.3 | GO:1901250 | regulation of lung goblet cell differentiation(GO:1901249) negative regulation of lung goblet cell differentiation(GO:1901250) |
0.0 | 0.3 | GO:0033008 | positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of mast cell degranulation(GO:0043306) |
0.0 | 0.7 | GO:0071625 | vocalization behavior(GO:0071625) |
0.0 | 0.5 | GO:0045956 | positive regulation of calcium ion-dependent exocytosis(GO:0045956) |
0.0 | 0.2 | GO:1900194 | negative regulation of oocyte maturation(GO:1900194) |
0.0 | 0.1 | GO:0003192 | mitral valve formation(GO:0003192) cell migration involved in endocardial cushion formation(GO:0003273) condensed mesenchymal cell proliferation(GO:0072137) |
0.0 | 0.3 | GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289) |
0.0 | 0.6 | GO:0010771 | negative regulation of cell morphogenesis involved in differentiation(GO:0010771) |
0.0 | 0.5 | GO:0016601 | Rac protein signal transduction(GO:0016601) |
0.0 | 0.5 | GO:0050919 | negative chemotaxis(GO:0050919) |
0.0 | 0.4 | GO:0007520 | myoblast fusion(GO:0007520) |
0.0 | 0.2 | GO:0031115 | negative regulation of microtubule polymerization(GO:0031115) |
0.0 | 0.1 | GO:0035269 | protein O-linked mannosylation(GO:0035269) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 2.2 | GO:0097512 | cardiac myofibril(GO:0097512) |
0.2 | 1.0 | GO:1990761 | growth cone lamellipodium(GO:1990761) |
0.1 | 0.4 | GO:0043512 | inhibin-betaglycan-ActRII complex(GO:0034673) inhibin A complex(GO:0043512) |
0.1 | 0.7 | GO:0097513 | myosin II filament(GO:0097513) |
0.1 | 0.3 | GO:0044194 | cytolytic granule(GO:0044194) |
0.1 | 0.8 | GO:0097550 | transcriptional preinitiation complex(GO:0097550) |
0.1 | 0.6 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
0.1 | 0.4 | GO:0042406 | extrinsic component of endoplasmic reticulum membrane(GO:0042406) |
0.1 | 0.9 | GO:0097449 | astrocyte projection(GO:0097449) |
0.1 | 0.5 | GO:0001520 | outer dense fiber(GO:0001520) |
0.1 | 0.6 | GO:0008024 | cyclin/CDK positive transcription elongation factor complex(GO:0008024) |
0.1 | 2.1 | GO:0000407 | pre-autophagosomal structure(GO:0000407) |
0.1 | 0.5 | GO:0042587 | glycogen granule(GO:0042587) |
0.0 | 0.4 | GO:0097427 | microtubule bundle(GO:0097427) |
0.0 | 0.5 | GO:0030123 | AP-3 adaptor complex(GO:0030123) HOPS complex(GO:0030897) |
0.0 | 0.1 | GO:0097441 | basilar dendrite(GO:0097441) |
0.0 | 0.1 | GO:0097443 | sorting endosome(GO:0097443) |
0.0 | 0.2 | GO:0031254 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
0.0 | 0.2 | GO:0033269 | internode region of axon(GO:0033269) |
0.0 | 0.5 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
0.0 | 0.2 | GO:0034464 | BBSome(GO:0034464) |
0.0 | 0.1 | GO:0005964 | phosphorylase kinase complex(GO:0005964) |
0.0 | 0.3 | GO:1990635 | proximal dendrite(GO:1990635) |
0.0 | 0.1 | GO:0031501 | mannosyltransferase complex(GO:0031501) |
0.0 | 0.7 | GO:0005776 | autophagosome(GO:0005776) |
0.0 | 0.8 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 0.9 | GO:0015272 | ATP-activated inward rectifier potassium channel activity(GO:0015272) |
0.3 | 0.8 | GO:0031798 | type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052) |
0.2 | 2.2 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
0.2 | 0.7 | GO:0015220 | choline transmembrane transporter activity(GO:0015220) |
0.1 | 0.6 | GO:0008332 | low voltage-gated calcium channel activity(GO:0008332) |
0.1 | 0.8 | GO:0016401 | palmitoyl-CoA oxidase activity(GO:0016401) |
0.1 | 0.5 | GO:0015226 | amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226) |
0.1 | 0.3 | GO:0008109 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109) |
0.1 | 0.4 | GO:0004515 | nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515) |
0.1 | 0.5 | GO:0004105 | choline-phosphate cytidylyltransferase activity(GO:0004105) |
0.1 | 0.3 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
0.1 | 0.6 | GO:0097322 | 7SK snRNA binding(GO:0097322) |
0.1 | 0.6 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
0.1 | 0.4 | GO:0009374 | biotin binding(GO:0009374) |
0.1 | 0.4 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
0.1 | 0.2 | GO:0001129 | RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129) RNA polymerase II transcription factor activity, TBP-class protein binding(GO:0001132) |
0.0 | 0.5 | GO:0004017 | adenylate kinase activity(GO:0004017) |
0.0 | 0.3 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
0.0 | 0.7 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
0.0 | 0.4 | GO:0034711 | inhibin binding(GO:0034711) |
0.0 | 2.4 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
0.0 | 0.4 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
0.0 | 1.0 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
0.0 | 0.4 | GO:0050897 | cobalt ion binding(GO:0050897) |
0.0 | 0.2 | GO:0016941 | natriuretic peptide receptor activity(GO:0016941) |
0.0 | 0.2 | GO:0005021 | vascular endothelial growth factor-activated receptor activity(GO:0005021) |
0.0 | 0.2 | GO:0034452 | dynactin binding(GO:0034452) |
0.0 | 1.0 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
0.0 | 0.4 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
0.0 | 0.1 | GO:0004689 | phosphorylase kinase activity(GO:0004689) |
0.0 | 0.2 | GO:0005229 | intracellular calcium activated chloride channel activity(GO:0005229) |
0.0 | 0.2 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
0.0 | 0.1 | GO:0004096 | catalase activity(GO:0004096) |
0.0 | 0.3 | GO:0030371 | translation repressor activity(GO:0030371) |
0.0 | 0.6 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 0.2 | PID_VEGF_VEGFR_PATHWAY | VEGF and VEGFR signaling network |
0.0 | 0.8 | PID_FOXM1_PATHWAY | FOXM1 transcription factor network |
0.0 | 0.4 | PID_MYC_PATHWAY | C-MYC pathway |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 0.4 | REACTOME_GLYCOPROTEIN_HORMONES | Genes involved in Glycoprotein hormones |
0.1 | 0.4 | REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS | Genes involved in Tandem pore domain potassium channels |
0.1 | 1.2 | REACTOME_SYNTHESIS_OF_PC | Genes involved in Synthesis of PC |
0.0 | 0.3 | REACTOME_TRANSPORT_OF_ORGANIC_ANIONS | Genes involved in Transport of organic anions |
0.0 | 0.8 | REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
0.0 | 1.1 | REACTOME_RAP1_SIGNALLING | Genes involved in Rap1 signalling |
0.0 | 0.5 | REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
0.0 | 0.6 | REACTOME_ELONGATION_ARREST_AND_RECOVERY | Genes involved in Elongation arrest and recovery |
0.0 | 0.9 | REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
0.0 | 0.7 | REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
0.0 | 0.5 | REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
0.0 | 0.8 | REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
0.0 | 0.2 | REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
0.0 | 0.6 | REACTOME_GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
0.0 | 0.3 | REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS | Genes involved in Activation of BH3-only proteins |
0.0 | 0.2 | REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
0.0 | 0.6 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
0.0 | 0.1 | REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
0.0 | 0.4 | REACTOME_SYNTHESIS_OF_PA | Genes involved in Synthesis of PA |