Motif ID: Hoxb1

Z-value: 0.747


Transcription factors associated with Hoxb1:

Gene SymbolEntrez IDGene Name
Hoxb1 ENSMUSG00000018973.2 Hoxb1



Activity profile for motif Hoxb1.

activity profile for motif Hoxb1


Sorted Z-values histogram for motif Hoxb1

Sorted Z-values for motif Hoxb1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_119053339 4.671 ENSMUST00000161301.1
ENSMUST00000161451.1
ENSMUST00000162607.1
Gli2


GLI-Kruppel family member GLI2


chr7_+_73391160 3.516 ENSMUST00000128471.1
Rgma
RGM domain family, member A
chr1_-_119053619 2.292 ENSMUST00000062483.8
Gli2
GLI-Kruppel family member GLI2
chr3_+_127633134 2.240 ENSMUST00000029587.7
Neurog2
neurogenin 2
chr5_-_24527276 1.647 ENSMUST00000088311.4
Gbx1
gastrulation brain homeobox 1
chr1_+_127306706 1.465 ENSMUST00000171405.1
Mgat5
mannoside acetylglucosaminyltransferase 5
chr8_-_87959560 1.424 ENSMUST00000109655.2
Zfp423
zinc finger protein 423
chr1_+_153665274 1.407 ENSMUST00000152114.1
ENSMUST00000111812.1
Rgs8

regulator of G-protein signaling 8

chr2_+_84840612 1.201 ENSMUST00000111625.1
Slc43a1
solute carrier family 43, member 1
chr1_-_45503282 1.134 ENSMUST00000086430.4
Col5a2
collagen, type V, alpha 2
chr14_-_69503220 1.116 ENSMUST00000180059.2
Gm21464
predicted gene, 21464
chr19_-_41743665 1.115 ENSMUST00000025993.3
Slit1
slit homolog 1 (Drosophila)
chr14_-_69284982 1.044 ENSMUST00000183882.1
ENSMUST00000037064.4
Slc25a37

solute carrier family 25, member 37

chr8_+_84901928 1.020 ENSMUST00000067060.7
Klf1
Kruppel-like factor 1 (erythroid)
chr5_+_139543889 1.014 ENSMUST00000174792.1
ENSMUST00000031523.8
Uncx

UNC homeobox

chr14_-_69503316 1.003 ENSMUST00000179116.2
Gm21464
predicted gene, 21464
chrX_+_110814390 0.948 ENSMUST00000078229.3
Pou3f4
POU domain, class 3, transcription factor 4
chr9_+_65890237 0.926 ENSMUST00000045802.6
2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr7_+_119690026 0.903 ENSMUST00000047045.8
Acsm4
acyl-CoA synthetase medium-chain family member 4
chr1_+_178798438 0.858 ENSMUST00000160789.1
Kif26b
kinesin family member 26B
chr3_-_88762244 0.826 ENSMUST00000183267.1
Syt11
synaptotagmin XI
chr10_-_92162753 0.824 ENSMUST00000182197.1
Rmst
rhabdomyosarcoma 2 associated transcript (non-coding RNA)
chr8_-_8639363 0.803 ENSMUST00000152698.1
Efnb2
ephrin B2
chr9_-_91365778 0.725 ENSMUST00000065360.3
Zic1
zinc finger protein of the cerebellum 1
chr10_+_127677064 0.689 ENSMUST00000118612.1
ENSMUST00000048099.4
Tmem194

transmembrane protein 194

chr18_-_56562187 0.682 ENSMUST00000171844.2
Aldh7a1
aldehyde dehydrogenase family 7, member A1
chr18_-_56562215 0.657 ENSMUST00000170309.1
Aldh7a1
aldehyde dehydrogenase family 7, member A1
chr9_-_91365756 0.607 ENSMUST00000034927.6
Zic1
zinc finger protein of the cerebellum 1
chr11_+_75486813 0.605 ENSMUST00000018449.4
ENSMUST00000102510.1
ENSMUST00000131283.1
Prpf8


pre-mRNA processing factor 8


chrX_+_143518671 0.552 ENSMUST00000134402.1
Pak3
p21 protein (Cdc42/Rac)-activated kinase 3
chr10_-_88605017 0.502 ENSMUST00000119185.1
ENSMUST00000121629.1
Mybpc1

myosin binding protein C, slow-type

chr16_-_56024628 0.455 ENSMUST00000119981.1
ENSMUST00000096021.3
Pcnp

PEST proteolytic signal containing nuclear protein

chr17_+_29490812 0.428 ENSMUST00000024811.6
Pim1
proviral integration site 1
chr3_-_58525867 0.418 ENSMUST00000029385.7
Serp1
stress-associated endoplasmic reticulum protein 1
chr2_+_119972699 0.405 ENSMUST00000066058.7
Mapkbp1
mitogen-activated protein kinase binding protein 1
chr18_-_56562261 0.342 ENSMUST00000066208.6
ENSMUST00000172734.1
Aldh7a1

aldehyde dehydrogenase family 7, member A1

chrX_+_20617503 0.339 ENSMUST00000115375.1
ENSMUST00000115374.1
ENSMUST00000084383.3
Rbm10


RNA binding motif protein 10


chr7_-_78577771 0.331 ENSMUST00000039438.7
Ntrk3
neurotrophic tyrosine kinase, receptor, type 3
chr17_-_85688252 0.328 ENSMUST00000024947.7
ENSMUST00000163568.2
Six2

sine oculis-related homeobox 2

chr4_+_118428078 0.308 ENSMUST00000006557.6
ENSMUST00000167636.1
ENSMUST00000102673.4
Elovl1


elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1


chr4_-_63662910 0.296 ENSMUST00000184252.1
Gm11214
predicted gene 11214
chr17_+_26941420 0.280 ENSMUST00000081285.3
ENSMUST00000177932.1
Syngap1

synaptic Ras GTPase activating protein 1 homolog (rat)

chr2_+_124610573 0.276 ENSMUST00000103239.3
ENSMUST00000103240.2
Sema6d

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D

chr7_+_48789003 0.265 ENSMUST00000118927.1
ENSMUST00000125280.1
Zdhhc13

zinc finger, DHHC domain containing 13

chr2_-_148045891 0.252 ENSMUST00000109964.1
Foxa2
forkhead box A2
chr2_+_124610278 0.232 ENSMUST00000051419.8
ENSMUST00000077847.5
ENSMUST00000078621.5
ENSMUST00000076335.5
Sema6d



sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D



chr1_+_39535747 0.215 ENSMUST00000003219.8
Cnot11
CCR4-NOT transcription complex, subunit 11
chr5_-_107289561 0.179 ENSMUST00000031224.8
Tgfbr3
transforming growth factor, beta receptor III
chr12_-_15816762 0.155 ENSMUST00000020922.7
Trib2
tribbles homolog 2 (Drosophila)
chr4_-_91399984 0.139 ENSMUST00000102799.3
Elavl2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr3_+_41564880 0.133 ENSMUST00000168086.1
Phf17
PHD finger protein 17
chr4_+_43669610 0.132 ENSMUST00000107866.1
Tmem8b
transmembrane protein 8B
chr4_-_103114555 0.127 ENSMUST00000106868.3
Wdr78
WD repeat domain 78
chr3_+_58526303 0.114 ENSMUST00000138848.1
Eif2a
eukaryotic translation initiation factor 2A
chr5_-_124354671 0.098 ENSMUST00000031341.4
Cdk2ap1
CDK2 (cyclin-dependent kinase 2)-associated protein 1
chr11_-_83298873 0.097 ENSMUST00000175741.1
ENSMUST00000176518.1
Pex12

peroxisomal biogenesis factor 12

chr4_-_103114238 0.071 ENSMUST00000036451.8
ENSMUST00000036557.8
Wdr78

WD repeat domain 78

chr10_-_63421739 0.070 ENSMUST00000054760.4
Gm7075
predicted gene 7075
chr5_+_42067960 0.056 ENSMUST00000087332.4
Gm16223
predicted gene 16223
chr5_+_37735519 0.049 ENSMUST00000073554.3
Cytl1
cytokine-like 1
chr5_+_136967859 0.042 ENSMUST00000001790.5
Cldn15
claudin 15
chr8_+_25808474 0.036 ENSMUST00000033979.4
Star
steroidogenic acute regulatory protein
chr2_-_153529941 0.035 ENSMUST00000035346.7
8430427H17Rik
RIKEN cDNA 8430427H17 gene
chr9_-_108083330 0.018 ENSMUST00000159372.1
ENSMUST00000160249.1
Rnf123

ring finger protein 123

chr1_-_157412576 0.018 ENSMUST00000078308.6
ENSMUST00000139470.1
Rasal2

RAS protein activator like 2

chr15_+_74516196 0.012 ENSMUST00000042035.9
Bai1
brain-specific angiogenesis inhibitor 1
chr8_-_117673682 0.005 ENSMUST00000173522.1
ENSMUST00000174450.1
Sdr42e1

short chain dehydrogenase/reductase family 42E, member 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 7.0 GO:0060032 notochord regression(GO:0060032)
0.4 1.6 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.4 1.1 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.3 0.3 GO:0072038 mesenchymal stem cell maintenance involved in nephron morphogenesis(GO:0072038)
0.3 3.5 GO:1900121 negative regulation of receptor binding(GO:1900121)
0.3 0.9 GO:0072092 ureteric bud invasion(GO:0072092)
0.3 0.8 GO:1990927 negative regulation of membrane invagination(GO:1905154) calcium ion regulated lysosome exocytosis(GO:1990927)
0.2 1.1 GO:0033563 dorsal/ventral axon guidance(GO:0033563)
0.1 1.0 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.1 0.3 GO:0048687 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
0.1 1.4 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.1 0.8 GO:1903847 regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.1 0.5 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.1 0.9 GO:2001054 negative regulation of mesenchymal cell apoptotic process(GO:2001054)
0.1 0.3 GO:0045014 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) detection of glucose(GO:0051594)
0.1 0.4 GO:0007256 activation of JNKK activity(GO:0007256)
0.1 1.0 GO:0043249 erythrocyte maturation(GO:0043249)
0.1 0.4 GO:0070561 vitamin D receptor signaling pathway(GO:0070561) positive regulation of cell proliferation involved in heart morphogenesis(GO:2000138)
0.1 0.2 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181) negative regulation of apoptotic process involved in morphogenesis(GO:1902338) negative regulation of apoptotic process involved in development(GO:1904746)
0.1 0.6 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 0.3 GO:0034393 positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.0 1.4 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 1.2 GO:0015804 neutral amino acid transport(GO:0015804)
0.0 0.4 GO:0060124 positive regulation of growth hormone secretion(GO:0060124)
0.0 0.3 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 1.0 GO:0006826 iron ion transport(GO:0006826)
0.0 1.3 GO:0007628 adult walking behavior(GO:0007628)
0.0 0.6 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.0 2.2 GO:0021954 central nervous system neuron development(GO:0021954)
0.0 0.5 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.0 0.2 GO:0032693 negative regulation of interleukin-10 production(GO:0032693)
0.0 1.5 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 0.9 GO:0035383 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 7.0 GO:0097542 ciliary tip(GO:0097542)
0.4 1.1 GO:0005588 collagen type V trimer(GO:0005588)
0.1 0.5 GO:0005859 muscle myosin complex(GO:0005859)
0.1 0.8 GO:0032009 early phagosome(GO:0032009)
0.1 0.2 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 1.0 GO:0005682 U5 snRNP(GO:0005682)
0.0 1.4 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 0.3 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 3.5 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.1 GO:1990415 Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429)
0.0 0.2 GO:0005858 axonemal dynein complex(GO:0005858)
0.0 0.9 GO:0005871 kinesin complex(GO:0005871)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 GO:0008802 betaine-aldehyde dehydrogenase activity(GO:0008802)
0.3 0.9 GO:0003996 acyl-CoA ligase activity(GO:0003996)
0.3 1.5 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.3 3.5 GO:1990459 transferrin receptor binding(GO:1990459)
0.2 0.6 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.2 6.5 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 1.1 GO:0048495 Roundabout binding(GO:0048495)
0.1 0.5 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 1.0 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
0.1 0.3 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.1 0.9 GO:0003680 AT DNA binding(GO:0003680)
0.0 2.2 GO:0070888 E-box binding(GO:0070888)
0.0 0.4 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.0 1.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.3 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 1.2 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 1.0 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.6 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.5 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.2 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.0 0.8 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 0.8 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.3 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 1.1 GO:0003777 microtubule motor activity(GO:0003777)
0.0 1.0 GO:0033613 activating transcription factor binding(GO:0033613)
0.0 0.2 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 7.0 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 3.5 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.4 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 1.1 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.8 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 1.1 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.6 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.6 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 1.5 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 1.2 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.5 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.5 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 1.1 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.6 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.3 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs