Motif ID: Crx_Gsc
Z-value: 0.566


Transcription factors associated with Crx_Gsc:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Crx | ENSMUSG00000041578.9 | Crx |
Gsc | ENSMUSG00000021095.4 | Gsc |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Crx | mm10_v2_chr7_-_15879844_15879968 | 0.36 | 1.5e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 1.0 | GO:0090273 | regulation of somatostatin secretion(GO:0090273) |
0.2 | 1.1 | GO:0042699 | follicle-stimulating hormone signaling pathway(GO:0042699) |
0.2 | 1.6 | GO:1900034 | regulation of cellular response to heat(GO:1900034) |
0.1 | 0.9 | GO:1902998 | macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
0.1 | 2.6 | GO:0031340 | positive regulation of vesicle fusion(GO:0031340) |
0.1 | 1.4 | GO:1903608 | protein localization to cytoplasmic stress granule(GO:1903608) |
0.1 | 0.8 | GO:0030643 | cellular phosphate ion homeostasis(GO:0030643) phosphate ion transmembrane transport(GO:0035435) cellular trivalent inorganic anion homeostasis(GO:0072502) |
0.1 | 0.6 | GO:0045578 | negative regulation of B cell differentiation(GO:0045578) epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030) |
0.1 | 0.5 | GO:2000525 | regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525) |
0.1 | 0.3 | GO:0032240 | RNA import into nucleus(GO:0006404) mRNA export from nucleus in response to heat stress(GO:0031990) negative regulation of nucleobase-containing compound transport(GO:0032240) negative regulation of RNA export from nucleus(GO:0046832) |
0.1 | 0.1 | GO:0061324 | canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation(GO:0061324) |
0.1 | 0.9 | GO:2001214 | positive regulation of vasculogenesis(GO:2001214) |
0.1 | 0.3 | GO:0060032 | notochord regression(GO:0060032) |
0.1 | 1.1 | GO:0043045 | DNA methylation involved in embryo development(GO:0043045) changes to DNA methylation involved in embryo development(GO:1901538) |
0.1 | 0.2 | GO:0072034 | renal vesicle induction(GO:0072034) |
0.1 | 0.8 | GO:0032486 | Rap protein signal transduction(GO:0032486) |
0.1 | 0.5 | GO:0061718 | NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718) |
0.1 | 0.2 | GO:0032918 | polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918) |
0.1 | 1.0 | GO:0010457 | centriole-centriole cohesion(GO:0010457) |
0.1 | 0.6 | GO:0042756 | drinking behavior(GO:0042756) |
0.1 | 0.5 | GO:0035887 | aortic smooth muscle cell differentiation(GO:0035887) |
0.1 | 0.3 | GO:0097116 | gephyrin clustering involved in postsynaptic density assembly(GO:0097116) |
0.1 | 0.3 | GO:0021856 | cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) facioacoustic ganglion development(GO:1903375) |
0.1 | 0.2 | GO:0033030 | negative regulation of neutrophil apoptotic process(GO:0033030) |
0.1 | 0.8 | GO:0010818 | T cell chemotaxis(GO:0010818) |
0.0 | 0.6 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
0.0 | 0.3 | GO:0003406 | retinal pigment epithelium development(GO:0003406) |
0.0 | 0.1 | GO:0060332 | positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335) |
0.0 | 0.2 | GO:0002188 | translation reinitiation(GO:0002188) |
0.0 | 0.4 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
0.0 | 0.2 | GO:0009794 | regulation of mitotic cell cycle, embryonic(GO:0009794) mitotic cell cycle, embryonic(GO:0045448) |
0.0 | 0.2 | GO:0034162 | toll-like receptor 9 signaling pathway(GO:0034162) |
0.0 | 0.5 | GO:0071243 | cellular response to arsenic-containing substance(GO:0071243) |
0.0 | 0.2 | GO:0071442 | positive regulation of histone H3-K14 acetylation(GO:0071442) |
0.0 | 0.4 | GO:0046541 | saliva secretion(GO:0046541) |
0.0 | 0.7 | GO:0006054 | N-acetylneuraminate metabolic process(GO:0006054) |
0.0 | 0.4 | GO:0071044 | histone mRNA catabolic process(GO:0071044) |
0.0 | 0.6 | GO:0033574 | response to testosterone(GO:0033574) |
0.0 | 0.1 | GO:0036228 | protein targeting to nuclear inner membrane(GO:0036228) |
0.0 | 0.1 | GO:0097155 | fasciculation of sensory neuron axon(GO:0097155) |
0.0 | 0.2 | GO:0051096 | regulation of helicase activity(GO:0051095) positive regulation of helicase activity(GO:0051096) |
0.0 | 0.1 | GO:0097401 | synaptic vesicle lumen acidification(GO:0097401) |
0.0 | 0.1 | GO:1901856 | negative regulation of cellular respiration(GO:1901856) |
0.0 | 0.8 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
0.0 | 0.2 | GO:0006003 | fructose 2,6-bisphosphate metabolic process(GO:0006003) |
0.0 | 0.6 | GO:0016486 | peptide hormone processing(GO:0016486) |
0.0 | 0.2 | GO:0019532 | oxalate transport(GO:0019532) |
0.0 | 0.2 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
0.0 | 0.5 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
0.0 | 0.3 | GO:0061158 | 3'-UTR-mediated mRNA destabilization(GO:0061158) |
0.0 | 0.1 | GO:0032621 | interleukin-18 production(GO:0032621) |
0.0 | 0.1 | GO:0006452 | translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905) |
0.0 | 0.0 | GO:0002669 | positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913) |
0.0 | 0.1 | GO:0046104 | thymidine metabolic process(GO:0046104) |
0.0 | 0.2 | GO:0002710 | negative regulation of T cell mediated immunity(GO:0002710) |
0.0 | 0.2 | GO:0035845 | photoreceptor cell outer segment organization(GO:0035845) |
0.0 | 0.2 | GO:0090315 | negative regulation of protein targeting to membrane(GO:0090315) |
0.0 | 1.3 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
0.0 | 2.0 | GO:0006413 | translational initiation(GO:0006413) |
0.0 | 0.1 | GO:0036444 | calcium ion transmembrane import into mitochondrion(GO:0036444) |
0.0 | 0.1 | GO:0006729 | tetrahydrobiopterin biosynthetic process(GO:0006729) pteridine-containing compound metabolic process(GO:0042558) pteridine-containing compound biosynthetic process(GO:0042559) tetrahydrobiopterin metabolic process(GO:0046146) |
0.0 | 0.1 | GO:1903527 | positive regulation of membrane tubulation(GO:1903527) |
0.0 | 0.3 | GO:0035987 | endodermal cell differentiation(GO:0035987) |
0.0 | 0.2 | GO:0018230 | peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231) |
0.0 | 0.4 | GO:0048268 | clathrin coat assembly(GO:0048268) |
0.0 | 1.2 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
0.0 | 0.1 | GO:0019919 | peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919) |
0.0 | 0.2 | GO:0060363 | cranial suture morphogenesis(GO:0060363) |
0.0 | 0.5 | GO:0021591 | ventricular system development(GO:0021591) |
0.0 | 0.1 | GO:0071985 | multivesicular body sorting pathway(GO:0071985) |
0.0 | 0.1 | GO:1903772 | regulation of viral budding via host ESCRT complex(GO:1903772) |
0.0 | 0.1 | GO:0051103 | DNA ligation involved in DNA repair(GO:0051103) |
0.0 | 0.1 | GO:0031293 | membrane protein intracellular domain proteolysis(GO:0031293) |
0.0 | 0.1 | GO:0031282 | regulation of guanylate cyclase activity(GO:0031282) |
0.0 | 0.3 | GO:0007608 | sensory perception of smell(GO:0007608) |
0.0 | 0.2 | GO:0007095 | mitotic G2 DNA damage checkpoint(GO:0007095) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 2.5 | GO:0097418 | neurofibrillary tangle(GO:0097418) |
0.1 | 1.0 | GO:0097165 | nuclear stress granule(GO:0097165) |
0.1 | 0.5 | GO:1903440 | calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440) |
0.1 | 1.1 | GO:0031143 | pseudopodium(GO:0031143) |
0.1 | 0.3 | GO:0044615 | nuclear pore nuclear basket(GO:0044615) |
0.0 | 1.5 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
0.0 | 0.1 | GO:1990851 | Wnt-Frizzled-LRP5/6 complex(GO:1990851) |
0.0 | 0.4 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
0.0 | 0.1 | GO:0031084 | BLOC-2 complex(GO:0031084) |
0.0 | 0.5 | GO:0097539 | ciliary transition fiber(GO:0097539) |
0.0 | 0.2 | GO:0005955 | calcineurin complex(GO:0005955) |
0.0 | 0.5 | GO:0071564 | npBAF complex(GO:0071564) |
0.0 | 0.1 | GO:1990246 | uniplex complex(GO:1990246) |
0.0 | 0.2 | GO:0042629 | mast cell granule(GO:0042629) |
0.0 | 0.3 | GO:0097542 | ciliary tip(GO:0097542) |
0.0 | 0.5 | GO:0097228 | sperm principal piece(GO:0097228) |
0.0 | 0.2 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
0.0 | 0.2 | GO:0032300 | mismatch repair complex(GO:0032300) |
0.0 | 0.1 | GO:0070522 | ERCC4-ERCC1 complex(GO:0070522) |
0.0 | 1.8 | GO:0005814 | centriole(GO:0005814) |
0.0 | 0.1 | GO:0071556 | integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553) |
0.0 | 0.3 | GO:0097470 | ribbon synapse(GO:0097470) |
0.0 | 1.2 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
0.0 | 0.1 | GO:0044613 | nuclear pore central transport channel(GO:0044613) |
0.0 | 0.1 | GO:0030991 | intraciliary transport particle A(GO:0030991) |
0.0 | 0.4 | GO:0030125 | clathrin vesicle coat(GO:0030125) |
0.0 | 0.1 | GO:0000138 | Golgi trans cisterna(GO:0000138) |
0.0 | 0.5 | GO:0060170 | ciliary membrane(GO:0060170) |
0.0 | 1.2 | GO:0016363 | nuclear matrix(GO:0016363) |
0.0 | 0.1 | GO:0045334 | clathrin-coated endocytic vesicle(GO:0045334) |
0.0 | 0.1 | GO:0032585 | multivesicular body membrane(GO:0032585) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 1.1 | GO:0031896 | V2 vasopressin receptor binding(GO:0031896) |
0.3 | 0.8 | GO:0000822 | inositol hexakisphosphate binding(GO:0000822) |
0.2 | 1.6 | GO:0099609 | microtubule lateral binding(GO:0099609) |
0.1 | 0.7 | GO:0003835 | beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835) |
0.1 | 0.4 | GO:0004534 | 5'-3' exoribonuclease activity(GO:0004534) |
0.1 | 1.5 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
0.1 | 0.3 | GO:0031779 | melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782) |
0.1 | 0.5 | GO:0097643 | amylin receptor activity(GO:0097643) |
0.1 | 0.5 | GO:0008865 | fructokinase activity(GO:0008865) mannokinase activity(GO:0019158) |
0.1 | 0.9 | GO:0005041 | low-density lipoprotein receptor activity(GO:0005041) |
0.1 | 0.2 | GO:0016494 | C-X-C chemokine receptor activity(GO:0016494) C-X-C chemokine binding(GO:0019958) |
0.1 | 0.2 | GO:0004145 | diamine N-acetyltransferase activity(GO:0004145) |
0.1 | 0.2 | GO:0032139 | dinucleotide insertion or deletion binding(GO:0032139) single guanine insertion binding(GO:0032142) |
0.1 | 0.4 | GO:0032051 | clathrin light chain binding(GO:0032051) |
0.1 | 1.0 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
0.1 | 2.6 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
0.1 | 1.8 | GO:0050750 | low-density lipoprotein particle receptor binding(GO:0050750) |
0.1 | 0.4 | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity(GO:0004726) |
0.1 | 0.3 | GO:0004984 | olfactory receptor activity(GO:0004984) |
0.0 | 0.2 | GO:0005093 | Rab GDP-dissociation inhibitor activity(GO:0005093) |
0.0 | 0.8 | GO:0043008 | ATP-dependent protein binding(GO:0043008) |
0.0 | 2.1 | GO:0003743 | translation initiation factor activity(GO:0003743) |
0.0 | 0.4 | GO:0070679 | inositol 1,4,5 trisphosphate binding(GO:0070679) |
0.0 | 0.6 | GO:0005003 | ephrin receptor activity(GO:0005003) |
0.0 | 0.2 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
0.0 | 0.1 | GO:0030249 | guanylate cyclase regulator activity(GO:0030249) |
0.0 | 0.1 | GO:0004155 | 6,7-dihydropteridine reductase activity(GO:0004155) |
0.0 | 1.0 | GO:0017091 | AU-rich element binding(GO:0017091) |
0.0 | 0.9 | GO:0070840 | dynein complex binding(GO:0070840) |
0.0 | 0.3 | GO:1990825 | sequence-specific mRNA binding(GO:1990825) |
0.0 | 0.2 | GO:0003873 | 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331) |
0.0 | 0.2 | GO:0019869 | chloride channel inhibitor activity(GO:0019869) |
0.0 | 0.1 | GO:0072320 | volume-sensitive chloride channel activity(GO:0072320) |
0.0 | 0.1 | GO:1990599 | 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599) |
0.0 | 0.8 | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity(GO:0003755) |
0.0 | 0.1 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
0.0 | 0.3 | GO:0042043 | neurexin family protein binding(GO:0042043) |
0.0 | 0.1 | GO:0031419 | cobalamin binding(GO:0031419) |
0.0 | 0.4 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
0.0 | 0.1 | GO:0030519 | snoRNP binding(GO:0030519) |
0.0 | 1.5 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
0.0 | 0.1 | GO:0019136 | deoxynucleoside kinase activity(GO:0019136) |
0.0 | 0.2 | GO:0019531 | secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531) |
0.0 | 0.2 | GO:0038191 | neuropilin binding(GO:0038191) |
0.0 | 0.4 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
0.0 | 0.1 | GO:0005134 | interleukin-2 receptor binding(GO:0005134) |
0.0 | 0.1 | GO:0008428 | ribonuclease inhibitor activity(GO:0008428) |
0.0 | 0.3 | GO:0031489 | myosin V binding(GO:0031489) |
0.0 | 0.0 | GO:0051185 | coenzyme transporter activity(GO:0051185) |
0.0 | 0.0 | GO:0004096 | catalase activity(GO:0004096) |
0.0 | 0.6 | GO:0046875 | ephrin receptor binding(GO:0046875) |
0.0 | 0.1 | GO:0042500 | aspartic endopeptidase activity, intramembrane cleaving(GO:0042500) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 1.3 | PID_THROMBIN_PAR4_PATHWAY | PAR4-mediated thrombin signaling events |
0.1 | 1.6 | PID_P38_GAMMA_DELTA_PATHWAY | Signaling mediated by p38-gamma and p38-delta |
0.0 | 1.2 | PID_ARF6_PATHWAY | Arf6 signaling events |
0.0 | 1.5 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
0.0 | 0.6 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
0.0 | 0.5 | PID_P38_MKK3_6PATHWAY | p38 MAPK signaling pathway |
0.0 | 0.5 | PID_FOXM1_PATHWAY | FOXM1 transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 1.6 | REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
0.1 | 2.4 | REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS | Genes involved in Thrombin signalling through proteinase activated receptors (PARs) |
0.0 | 0.6 | REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX | Genes involved in Degradation of the extracellular matrix |
0.0 | 0.4 | REACTOME_CS_DS_DEGRADATION | Genes involved in CS/DS degradation |
0.0 | 0.2 | REACTOME_DARPP_32_EVENTS | Genes involved in DARPP-32 events |
0.0 | 0.2 | REACTOME_KERATAN_SULFATE_DEGRADATION | Genes involved in Keratan sulfate degradation |
0.0 | 0.9 | REACTOME_GLUCOSE_TRANSPORT | Genes involved in Glucose transport |
0.0 | 0.4 | REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP | Genes involved in Destabilization of mRNA by Tristetraprolin (TTP) |
0.0 | 0.3 | REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
0.0 | 0.1 | REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |