Motif ID: Klf7

Z-value: 0.578


Transcription factors associated with Klf7:

Gene SymbolEntrez IDGene Name
Klf7 ENSMUSG00000025959.7 Klf7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf7mm10_v2_chr1_-_64121389_64121452-0.253.2e-01Click!


Activity profile for motif Klf7.

activity profile for motif Klf7


Sorted Z-values histogram for motif Klf7

Sorted Z-values for motif Klf7



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf7

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrY_+_897782 2.387 ENSMUST00000055032.7
Kdm5d
lysine (K)-specific demethylase 5D
chr12_-_4592927 1.282 ENSMUST00000170816.1
Gm3625
predicted gene 3625
chr6_-_88874597 0.485 ENSMUST00000061262.4
ENSMUST00000140455.1
ENSMUST00000145780.1
Podxl2


podocalyxin-like 2


chr10_+_86705811 0.484 ENSMUST00000061458.7
ENSMUST00000075632.6
BC030307

cDNA sequence BC030307

chr6_-_88875035 0.452 ENSMUST00000145944.1
Podxl2
podocalyxin-like 2
chr3_+_28263205 0.436 ENSMUST00000159236.2
Tnik
TRAF2 and NCK interacting kinase
chr2_+_32775769 0.333 ENSMUST00000066352.5
Ptrh1
peptidyl-tRNA hydrolase 1 homolog (S. cerevisiae)
chr3_+_106721893 0.310 ENSMUST00000106736.2
ENSMUST00000154973.1
ENSMUST00000131330.1
ENSMUST00000150513.1
Lrif1



ligand dependent nuclear receptor interacting factor 1



chr8_+_3621529 0.306 ENSMUST00000156380.2
Pet100
PET100 homolog (S. cerevisiae)
chr5_+_137761680 0.299 ENSMUST00000110983.2
ENSMUST00000031738.4
Tsc22d4

TSC22 domain family, member 4

chr2_-_156312470 0.293 ENSMUST00000079125.6
Scand1
SCAN domain-containing 1
chr6_+_125039760 0.291 ENSMUST00000140131.1
ENSMUST00000032480.7
Ing4

inhibitor of growth family, member 4

chr1_-_23383149 0.289 ENSMUST00000027343.5
Ogfrl1
opioid growth factor receptor-like 1
chr15_-_89196457 0.287 ENSMUST00000078953.7
Dennd6b
DENN/MADD domain containing 6B
chr7_-_28766469 0.280 ENSMUST00000085851.5
ENSMUST00000032815.4
Nfkbib

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta

chr19_+_8723478 0.277 ENSMUST00000180819.1
ENSMUST00000181422.1
Snhg1

small nucleolar RNA host gene (non-protein coding) 1

chrX_+_136270253 0.268 ENSMUST00000178632.1
ENSMUST00000053540.4
Ngfrap1

nerve growth factor receptor (TNFRSF16) associated protein 1

chr3_+_106721672 0.268 ENSMUST00000098750.2
ENSMUST00000130105.1
Lrif1

ligand dependent nuclear receptor interacting factor 1

chr2_+_156312589 0.267 ENSMUST00000073942.5
ENSMUST00000109580.1
Cnbd2

cyclic nucleotide binding domain containing 2

chr10_-_86705485 0.258 ENSMUST00000020238.7
Hsp90b1
heat shock protein 90, beta (Grp94), member 1
chr4_+_127126034 0.257 ENSMUST00000094712.4
Gm12942
predicted gene 12942
chr11_+_78536355 0.251 ENSMUST00000128788.1
Ift20
intraflagellar transport 20
chr4_-_132329414 0.249 ENSMUST00000127402.1
ENSMUST00000105962.3
ENSMUST00000030730.7
ENSMUST00000105960.1
Trnau1ap



tRNA selenocysteine 1 associated protein 1



chr5_+_137778849 0.244 ENSMUST00000126126.1
ENSMUST00000031739.4
Ppp1r35

protein phosphatase 1, regulatory subunit 35

chr5_-_137741601 0.236 ENSMUST00000119498.1
ENSMUST00000061789.7
Nyap1

neuronal tyrosine-phosphorylated phosphoinositide 3-kinase adaptor 1

chr4_+_152178126 0.221 ENSMUST00000075363.3
Acot7
acyl-CoA thioesterase 7
chr5_-_115348953 0.218 ENSMUST00000040154.8
Cox6a1
cytochrome c oxidase subunit VIa polypeptide 1
chr18_+_67133713 0.215 ENSMUST00000076605.7
Gnal
guanine nucleotide binding protein, alpha stimulating, olfactory type
chr2_-_32694120 0.213 ENSMUST00000028148.4
Fpgs
folylpolyglutamyl synthetase
chr8_+_71367210 0.212 ENSMUST00000019169.7
Use1
unconventional SNARE in the ER 1 homolog (S. cerevisiae)
chr16_-_91931643 0.210 ENSMUST00000023677.3
Atp5o
ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit
chr1_-_138847579 0.206 ENSMUST00000093486.3
ENSMUST00000046870.6
Lhx9

LIM homeobox protein 9

chr7_+_28350652 0.199 ENSMUST00000082134.4
Rps16
ribosomal protein S16
chr7_+_45154297 0.196 ENSMUST00000107813.1
ENSMUST00000125953.1
ENSMUST00000085375.5
ENSMUST00000144597.1
Pih1d1



PIH1 domain containing 1



chr2_-_151973387 0.196 ENSMUST00000109863.1
Fam110a
family with sequence similarity 110, member A
chr8_+_84901928 0.192 ENSMUST00000067060.7
Klf1
Kruppel-like factor 1 (erythroid)
chr11_+_78536393 0.191 ENSMUST00000050366.8
ENSMUST00000108275.1
Ift20

intraflagellar transport 20

chr1_-_120121030 0.184 ENSMUST00000027634.6
Dbi
diazepam binding inhibitor
chr12_+_49383007 0.181 ENSMUST00000021333.3
Foxg1
forkhead box G1
chr12_+_49382791 0.171 ENSMUST00000179669.1
Foxg1
forkhead box G1
chr1_+_120121161 0.168 ENSMUST00000027637.6
ENSMUST00000112644.2
ENSMUST00000056038.8
3110009E18Rik


RIKEN cDNA 3110009E18 gene


chr15_-_98953541 0.168 ENSMUST00000097014.5
Tuba1a
tubulin, alpha 1A
chr12_-_11436607 0.166 ENSMUST00000072299.5
Vsnl1
visinin-like 1
chr8_-_22476809 0.164 ENSMUST00000163774.1
ENSMUST00000033935.8
Smim19

small integral membrane protein 19

chr2_-_73892619 0.163 ENSMUST00000112007.1
ENSMUST00000112016.2
Atf2

activating transcription factor 2

chr7_+_28766747 0.163 ENSMUST00000170068.1
ENSMUST00000072965.4
Sirt2

sirtuin 2

chr1_-_58445369 0.162 ENSMUST00000114345.2
ENSMUST00000117069.1
ENSMUST00000114348.1
ENSMUST00000081677.5
Ppil3



peptidylprolyl isomerase (cyclophilin)-like 3



chr2_+_158375638 0.156 ENSMUST00000109488.1
Snhg11
small nucleolar RNA host gene 11
chr7_-_19404082 0.155 ENSMUST00000108458.3
Klc3
kinesin light chain 3
chr6_+_52713729 0.144 ENSMUST00000080723.4
ENSMUST00000149588.1
Tax1bp1

Tax1 (human T cell leukemia virus type I) binding protein 1

chr4_+_139622842 0.140 ENSMUST00000039818.9
Aldh4a1
aldehyde dehydrogenase 4 family, member A1
chr8_+_3500451 0.121 ENSMUST00000004683.6
ENSMUST00000160338.1
Mcoln1

mucolipin 1

chr11_+_68432112 0.120 ENSMUST00000021283.7
Pik3r5
phosphoinositide-3-kinase, regulatory subunit 5, p101
chr5_-_34187670 0.119 ENSMUST00000042701.6
ENSMUST00000119171.1
Mxd4

Max dimerization protein 4

chr11_-_70654624 0.118 ENSMUST00000018437.2
Pfn1
profilin 1
chr11_-_61494173 0.117 ENSMUST00000101085.2
ENSMUST00000079080.6
ENSMUST00000108714.1
Mapk7


mitogen-activated protein kinase 7


chr1_+_167689108 0.114 ENSMUST00000111377.1
Lmx1a
LIM homeobox transcription factor 1 alpha
chr2_+_34772089 0.108 ENSMUST00000028222.6
ENSMUST00000100171.2
Hspa5

heat shock protein 5

chr2_-_156180135 0.107 ENSMUST00000126992.1
ENSMUST00000146288.1
ENSMUST00000029149.6
ENSMUST00000109587.2
ENSMUST00000109584.1
Rbm39




RNA binding motif protein 39




chr1_+_63176818 0.100 ENSMUST00000129339.1
Eef1b2
eukaryotic translation elongation factor 1 beta 2
chr15_-_102722150 0.096 ENSMUST00000023818.3
Calcoco1
calcium binding and coiled coil domain 1
chr2_-_73892588 0.095 ENSMUST00000154456.1
ENSMUST00000090802.4
ENSMUST00000055833.5
Atf2


activating transcription factor 2


chr19_+_5637475 0.095 ENSMUST00000025867.5
Rela
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
chr11_+_72301613 0.094 ENSMUST00000151440.1
ENSMUST00000146233.1
ENSMUST00000140842.2
Xaf1


XIAP associated factor 1


chr13_+_96542727 0.092 ENSMUST00000077672.4
ENSMUST00000109444.2
Col4a3bp

collagen, type IV, alpha 3 (Goodpasture antigen) binding protein

chr19_-_8723356 0.092 ENSMUST00000170157.1
Slc3a2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr1_-_57406443 0.091 ENSMUST00000160837.1
ENSMUST00000161780.1
Tyw5

tRNA-yW synthesizing protein 5

chr15_-_102722120 0.089 ENSMUST00000171838.1
Calcoco1
calcium binding and coiled coil domain 1
chr13_+_21722057 0.088 ENSMUST00000110476.3
Hist1h2bm
histone cluster 1, H2bm
chr1_-_120120937 0.087 ENSMUST00000151708.1
Dbi
diazepam binding inhibitor
chr4_-_87230435 0.086 ENSMUST00000107157.2
Slc24a2
solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
chr1_+_57406328 0.084 ENSMUST00000027114.5
9430016H08Rik
RIKEN cDNA 9430016H08 gene
chr7_-_141414115 0.083 ENSMUST00000106008.1
Pddc1
Parkinson disease 7 domain containing 1
chr11_-_78176619 0.082 ENSMUST00000148154.2
ENSMUST00000017549.6
Nek8

NIMA (never in mitosis gene a)-related expressed kinase 8

chr5_+_115631902 0.082 ENSMUST00000031492.8
Rab35
RAB35, member RAS oncogene family
chr7_+_45154644 0.079 ENSMUST00000153973.1
Pih1d1
PIH1 domain containing 1
chr10_+_79682169 0.077 ENSMUST00000020550.5
Cdc34
cell division cycle 34
chr7_+_126976338 0.068 ENSMUST00000032920.3
Cdipt
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)
chr6_+_52714219 0.065 ENSMUST00000138040.1
ENSMUST00000129660.1
Tax1bp1

Tax1 (human T cell leukemia virus type I) binding protein 1

chr4_+_107830958 0.063 ENSMUST00000106731.2
Lrp8
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
chr2_+_181497223 0.063 ENSMUST00000108799.3
Tpd52l2
tumor protein D52-like 2
chr5_+_44100442 0.049 ENSMUST00000072800.4
Gm16401
predicted gene 16401
chr2_-_130424242 0.043 ENSMUST00000089581.4
Pced1a
PC-esterase domain containing 1A
chr7_+_80261202 0.041 ENSMUST00000117989.1
Ngrn
neugrin, neurite outgrowth associated
chr8_+_71922810 0.036 ENSMUST00000119003.1
Zfp617
zinc finger protein 617
chr11_-_101302206 0.033 ENSMUST00000140706.1
ENSMUST00000170502.1
ENSMUST00000172233.1
ENSMUST00000130916.1
Becn1



beclin 1, autophagy related



chr14_+_50807915 0.027 ENSMUST00000036126.5
Parp2
poly (ADP-ribose) polymerase family, member 2
chr2_-_73892530 0.027 ENSMUST00000136958.1
ENSMUST00000112010.2
ENSMUST00000128531.1
ENSMUST00000112017.1
Atf2



activating transcription factor 2



chr2_+_119047116 0.025 ENSMUST00000152380.1
ENSMUST00000099542.2
Casc5

cancer susceptibility candidate 5

chr5_+_45520221 0.025 ENSMUST00000156481.1
ENSMUST00000119579.1
ENSMUST00000118833.1
Med28


mediator of RNA polymerase II transcription, subunit 28 homolog (yeast)


chr1_+_58445531 0.020 ENSMUST00000151272.1
Nif3l1
Ngg1 interacting factor 3-like 1 (S. pombe)
chr8_-_84966008 0.020 ENSMUST00000109738.3
ENSMUST00000065049.8
ENSMUST00000128972.1
Rnaseh2a


ribonuclease H2, large subunit


chr11_-_110251736 0.019 ENSMUST00000044003.7
Abca6
ATP-binding cassette, sub-family A (ABC1), member 6
chr11_-_106779483 0.016 ENSMUST00000021060.5
Polg2
polymerase (DNA directed), gamma 2, accessory subunit
chr9_-_32344237 0.011 ENSMUST00000034533.5
Kcnj5
potassium inwardly-rectifying channel, subfamily J, member 5
chr17_+_26113286 0.006 ENSMUST00000025010.7
Tmem8
transmembrane protein 8 (five membrane-spanning domains)
chr13_-_14613017 0.004 ENSMUST00000015816.3
Mrpl32
mitochondrial ribosomal protein L32
chr2_+_181497165 0.003 ENSMUST00000149163.1
ENSMUST00000000844.8
ENSMUST00000184849.1
ENSMUST00000108800.1
ENSMUST00000069712.2
Tpd52l2




tumor protein D52-like 2




chr9_-_88438898 0.002 ENSMUST00000173011.1
ENSMUST00000174806.1
Snx14

sorting nexin 14


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.4 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.1 0.4 GO:0021852 pyramidal neuron migration(GO:0021852)
0.1 0.3 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.1 0.4 GO:0007256 activation of JNKK activity(GO:0007256)
0.1 0.2 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.1 0.3 GO:1900110 negative regulation of histone H3-K9 dimethylation(GO:1900110)
0.1 0.2 GO:1900533 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
0.1 0.9 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.1 0.2 GO:1900226 negative regulation of NLRP3 inflammasome complex assembly(GO:1900226)
0.1 0.3 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
0.0 0.4 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.0 0.3 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.0 0.3 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.0 0.2 GO:0035262 gonad morphogenesis(GO:0035262)
0.0 0.1 GO:0070375 ERK5 cascade(GO:0070375)
0.0 0.1 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.0 0.2 GO:0009405 pathogenesis(GO:0009405)
0.0 0.2 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0 0.3 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.0 0.2 GO:0006451 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0 0.1 GO:0035621 ER to Golgi ceramide transport(GO:0035621) ceramide transport(GO:0035627)
0.0 0.1 GO:0031590 wybutosine metabolic process(GO:0031590) wybutosine biosynthetic process(GO:0031591)
0.0 0.2 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.1 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0 0.3 GO:0071318 cellular response to ATP(GO:0071318)
0.0 0.1 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.0 0.3 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 0.1 GO:0015803 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0 0.1 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.0 0.1 GO:0006560 proline metabolic process(GO:0006560)
0.0 0.2 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.0 0.1 GO:0048227 plasma membrane to endosome transport(GO:0048227)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:1902636 kinociliary basal body(GO:1902636)
0.0 0.3 GO:0097255 R2TP complex(GO:0097255)
0.0 0.1 GO:0097651 phosphatidylinositol 3-kinase complex, class I(GO:0097651)
0.0 0.4 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.2 GO:0033010 paranodal junction(GO:0033010)
0.0 0.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.3 GO:0055037 recycling endosome(GO:0055037)
0.0 0.2 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.2 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.1 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.0 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.4 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.1 0.3 GO:0030156 benzodiazepine receptor binding(GO:0030156)
0.1 0.3 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0 0.2 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739) tubulin deacetylase activity(GO:0042903)
0.0 0.3 GO:0046790 virion binding(GO:0046790)
0.0 0.4 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.1 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.0 0.2 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.0 0.3 GO:0001163 RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.0 0.1 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.0 0.1 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.1 GO:0071532 ankyrin repeat binding(GO:0071532)
0.0 0.1 GO:0038025 reelin receptor activity(GO:0038025)
0.0 0.1 GO:0097001 ceramide binding(GO:0097001)
0.0 0.3 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.1 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.2 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.6 GO:0042974 retinoic acid receptor binding(GO:0042974)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.2 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.4 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.4 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.4 REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.3 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.2 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.1 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.0 0.2 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway