Motif ID: Mef2b
Z-value: 0.778

Transcription factors associated with Mef2b:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Mef2b | ENSMUSG00000079033.3 | Mef2b |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Mef2b | mm10_v2_chr8_+_70152754_70152781 | 0.37 | 1.3e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.7 | 2.8 | GO:0042414 | epinephrine metabolic process(GO:0042414) |
0.5 | 2.6 | GO:0015705 | iodide transport(GO:0015705) |
0.5 | 2.7 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
0.4 | 2.2 | GO:0015671 | oxygen transport(GO:0015671) |
0.3 | 0.9 | GO:0042908 | xenobiotic transport(GO:0042908) |
0.3 | 0.9 | GO:1902310 | positive regulation of peptidyl-serine dephosphorylation(GO:1902310) |
0.3 | 0.8 | GO:0070889 | platelet alpha granule organization(GO:0070889) |
0.3 | 1.4 | GO:0090669 | snoRNA guided rRNA pseudouridine synthesis(GO:0000454) telomerase RNA stabilization(GO:0090669) |
0.3 | 0.8 | GO:0060023 | soft palate development(GO:0060023) |
0.2 | 0.6 | GO:0042264 | peptidyl-aspartic acid hydroxylation(GO:0042264) |
0.2 | 0.7 | GO:0051866 | general adaptation syndrome(GO:0051866) |
0.2 | 0.7 | GO:0010510 | regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) |
0.2 | 1.0 | GO:0030644 | cellular chloride ion homeostasis(GO:0030644) |
0.2 | 0.8 | GO:0051365 | cellular response to potassium ion starvation(GO:0051365) |
0.1 | 0.6 | GO:0019287 | isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287) |
0.1 | 0.4 | GO:0070315 | G1 to G0 transition involved in cell differentiation(GO:0070315) |
0.1 | 0.6 | GO:0034196 | acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197) |
0.1 | 0.3 | GO:0035523 | protein K29-linked deubiquitination(GO:0035523) protein K6-linked deubiquitination(GO:0044313) |
0.1 | 0.7 | GO:0098535 | positive regulation of centriole replication(GO:0046601) de novo centriole assembly(GO:0098535) |
0.1 | 0.3 | GO:0014835 | myoblast differentiation involved in skeletal muscle regeneration(GO:0014835) |
0.1 | 0.4 | GO:1901164 | negative regulation of trophoblast cell migration(GO:1901164) |
0.1 | 0.3 | GO:0090282 | positive regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071931) positive regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0090282) |
0.1 | 0.2 | GO:0006419 | alanyl-tRNA aminoacylation(GO:0006419) |
0.1 | 0.5 | GO:1900262 | regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264) |
0.1 | 0.8 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
0.1 | 0.2 | GO:1903028 | regulation of opsonization(GO:1903027) positive regulation of opsonization(GO:1903028) |
0.0 | 0.8 | GO:0045723 | positive regulation of fatty acid biosynthetic process(GO:0045723) |
0.0 | 0.5 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
0.0 | 0.9 | GO:0046069 | cGMP catabolic process(GO:0046069) |
0.0 | 0.3 | GO:0035093 | spermatogenesis, exchange of chromosomal proteins(GO:0035093) |
0.0 | 0.3 | GO:1902866 | regulation of retina development in camera-type eye(GO:1902866) |
0.0 | 0.5 | GO:1901409 | positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
0.0 | 0.5 | GO:0060732 | positive regulation of inositol phosphate biosynthetic process(GO:0060732) |
0.0 | 0.6 | GO:0045899 | positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899) |
0.0 | 0.7 | GO:0036297 | interstrand cross-link repair(GO:0036297) |
0.0 | 0.3 | GO:0045743 | positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743) |
0.0 | 0.3 | GO:0043569 | negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569) |
0.0 | 0.2 | GO:0045347 | negative regulation of MHC class II biosynthetic process(GO:0045347) |
0.0 | 0.7 | GO:0045653 | negative regulation of megakaryocyte differentiation(GO:0045653) |
0.0 | 0.2 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
0.0 | 0.2 | GO:0075525 | viral translational termination-reinitiation(GO:0075525) |
0.0 | 0.1 | GO:0016340 | calcium-dependent cell-matrix adhesion(GO:0016340) |
0.0 | 0.5 | GO:0099628 | receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628) |
0.0 | 0.6 | GO:0042178 | xenobiotic catabolic process(GO:0042178) |
0.0 | 0.3 | GO:0043615 | astrocyte cell migration(GO:0043615) |
0.0 | 0.2 | GO:0033683 | nucleotide-excision repair, DNA incision(GO:0033683) double-strand break repair via single-strand annealing(GO:0045002) |
0.0 | 0.1 | GO:2000468 | regulation of peroxidase activity(GO:2000468) |
0.0 | 0.1 | GO:1903225 | negative regulation of endodermal cell differentiation(GO:1903225) |
0.0 | 0.2 | GO:0035735 | intraciliary transport involved in cilium morphogenesis(GO:0035735) |
0.0 | 0.5 | GO:0019369 | drug metabolic process(GO:0017144) arachidonic acid metabolic process(GO:0019369) |
0.0 | 0.8 | GO:0010107 | potassium ion import(GO:0010107) |
0.0 | 0.6 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
0.0 | 0.2 | GO:0015879 | carnitine transport(GO:0015879) |
0.0 | 0.3 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
0.0 | 0.9 | GO:0015909 | long-chain fatty acid transport(GO:0015909) |
0.0 | 0.1 | GO:0060800 | regulation of cell differentiation involved in embryonic placenta development(GO:0060800) |
0.0 | 1.0 | GO:0035082 | axoneme assembly(GO:0035082) |
0.0 | 0.5 | GO:0044381 | glucose import in response to insulin stimulus(GO:0044381) |
0.0 | 0.1 | GO:0071494 | cellular response to UV-C(GO:0071494) |
0.0 | 0.4 | GO:1902043 | positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043) |
0.0 | 0.3 | GO:0000338 | protein deneddylation(GO:0000338) |
0.0 | 0.2 | GO:0001672 | regulation of chromatin assembly or disassembly(GO:0001672) |
0.0 | 0.9 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
0.0 | 0.2 | GO:1903504 | regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504) |
0.0 | 0.8 | GO:0032611 | interleukin-1 beta production(GO:0032611) |
0.0 | 0.0 | GO:0034372 | very-low-density lipoprotein particle remodeling(GO:0034372) |
0.0 | 0.7 | GO:0048384 | retinoic acid receptor signaling pathway(GO:0048384) |
0.0 | 0.1 | GO:0042256 | mature ribosome assembly(GO:0042256) |
0.0 | 0.0 | GO:0015866 | ADP transport(GO:0015866) |
0.0 | 0.4 | GO:0010960 | magnesium ion homeostasis(GO:0010960) |
0.0 | 0.1 | GO:0072697 | protein localization to cell cortex(GO:0072697) |
0.0 | 0.3 | GO:0071425 | hematopoietic stem cell proliferation(GO:0071425) |
0.0 | 0.1 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
0.0 | 0.1 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.9 | 2.8 | GO:0045009 | melanosome membrane(GO:0033162) chitosome(GO:0045009) |
0.3 | 1.4 | GO:0090661 | box H/ACA telomerase RNP complex(GO:0090661) |
0.3 | 2.2 | GO:0005833 | hemoglobin complex(GO:0005833) |
0.2 | 0.5 | GO:0099573 | glutamatergic postsynaptic density(GO:0099573) |
0.1 | 0.8 | GO:0035976 | AP1 complex(GO:0035976) |
0.1 | 0.7 | GO:0098536 | deuterosome(GO:0098536) |
0.1 | 1.0 | GO:0001939 | female pronucleus(GO:0001939) |
0.1 | 0.5 | GO:0005663 | DNA replication factor C complex(GO:0005663) |
0.1 | 3.4 | GO:0034707 | chloride channel complex(GO:0034707) |
0.1 | 0.7 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
0.1 | 0.6 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
0.1 | 0.3 | GO:0031466 | Cul5-RING ubiquitin ligase complex(GO:0031466) |
0.1 | 0.6 | GO:0031595 | nuclear proteasome complex(GO:0031595) |
0.0 | 0.8 | GO:0031528 | microvillus membrane(GO:0031528) |
0.0 | 0.3 | GO:0005859 | muscle myosin complex(GO:0005859) |
0.0 | 1.1 | GO:0000788 | nuclear nucleosome(GO:0000788) |
0.0 | 0.1 | GO:0005588 | collagen type V trimer(GO:0005588) |
0.0 | 0.6 | GO:0008305 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
0.0 | 0.5 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
0.0 | 0.1 | GO:0044753 | amphisome(GO:0044753) |
0.0 | 0.2 | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541) |
0.0 | 0.3 | GO:0032039 | integrator complex(GO:0032039) |
0.0 | 0.1 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
0.0 | 0.3 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
0.0 | 0.2 | GO:0097225 | sperm midpiece(GO:0097225) |
0.0 | 1.0 | GO:0036126 | sperm flagellum(GO:0036126) |
0.0 | 1.0 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
0.0 | 0.8 | GO:0030118 | clathrin coat(GO:0030118) |
0.0 | 0.8 | GO:0005581 | collagen trimer(GO:0005581) |
0.0 | 1.1 | GO:0005814 | centriole(GO:0005814) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.7 | 2.6 | GO:0015111 | iodide transmembrane transporter activity(GO:0015111) |
0.6 | 2.8 | GO:0035240 | dopamine binding(GO:0035240) |
0.5 | 2.2 | GO:0031721 | hemoglobin alpha binding(GO:0031721) |
0.3 | 1.4 | GO:0055056 | D-glucose transmembrane transporter activity(GO:0055056) |
0.3 | 0.9 | GO:0004647 | phosphoserine phosphatase activity(GO:0004647) |
0.3 | 1.0 | GO:0004111 | creatine kinase activity(GO:0004111) |
0.2 | 1.4 | GO:0034513 | box H/ACA snoRNA binding(GO:0034513) |
0.2 | 0.5 | GO:0003953 | NAD+ nucleosidase activity(GO:0003953) |
0.2 | 0.9 | GO:0004095 | carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416) |
0.2 | 0.7 | GO:0004740 | pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740) |
0.2 | 0.8 | GO:0004594 | pantothenate kinase activity(GO:0004594) |
0.2 | 0.8 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
0.2 | 0.5 | GO:0008392 | arachidonic acid epoxygenase activity(GO:0008392) |
0.1 | 0.6 | GO:0098639 | collagen binding involved in cell-matrix adhesion(GO:0098639) |
0.1 | 0.9 | GO:0048101 | calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
0.1 | 0.6 | GO:0036402 | proteasome-activating ATPase activity(GO:0036402) |
0.1 | 0.5 | GO:0051525 | NFAT protein binding(GO:0051525) |
0.1 | 0.2 | GO:0004769 | steroid delta-isomerase activity(GO:0004769) |
0.1 | 0.7 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
0.1 | 0.2 | GO:0008534 | oxidized purine nucleobase lesion DNA N-glycosylase activity(GO:0008534) |
0.1 | 0.3 | GO:1904288 | BAT3 complex binding(GO:1904288) |
0.1 | 0.2 | GO:0004813 | alanine-tRNA ligase activity(GO:0004813) |
0.1 | 0.2 | GO:0005124 | scavenger receptor binding(GO:0005124) |
0.1 | 0.4 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
0.1 | 0.3 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
0.1 | 0.4 | GO:0031432 | titin binding(GO:0031432) |
0.0 | 0.6 | GO:0019855 | calcium channel inhibitor activity(GO:0019855) |
0.0 | 0.5 | GO:0003689 | DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) |
0.0 | 0.4 | GO:0009019 | tRNA (guanine-N1-)-methyltransferase activity(GO:0009019) |
0.0 | 0.4 | GO:0035251 | UDP-glucosyltransferase activity(GO:0035251) |
0.0 | 0.8 | GO:0035497 | cAMP response element binding(GO:0035497) |
0.0 | 0.5 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
0.0 | 0.5 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
0.0 | 0.7 | GO:0003708 | retinoic acid receptor activity(GO:0003708) |
0.0 | 0.1 | GO:0005332 | gamma-aminobutyric acid:sodium symporter activity(GO:0005332) |
0.0 | 0.6 | GO:0070402 | NADPH binding(GO:0070402) |
0.0 | 0.3 | GO:0015347 | sodium-independent organic anion transmembrane transporter activity(GO:0015347) |
0.0 | 0.3 | GO:0001055 | RNA polymerase II activity(GO:0001055) |
0.0 | 0.3 | GO:0004445 | inositol-polyphosphate 5-phosphatase activity(GO:0004445) inositol trisphosphate phosphatase activity(GO:0046030) |
0.0 | 0.7 | GO:0034185 | apolipoprotein binding(GO:0034185) |
0.0 | 0.1 | GO:0009383 | rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383) |
0.0 | 0.9 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
0.0 | 0.1 | GO:0034211 | GTP-dependent protein kinase activity(GO:0034211) |
0.0 | 0.1 | GO:0001129 | RNA polymerase III transcription factor activity, sequence-specific DNA binding(GO:0001034) RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129) RNA polymerase II transcription factor activity, TBP-class protein binding(GO:0001132) |
0.0 | 0.5 | GO:0017046 | peptide hormone binding(GO:0017046) |
0.0 | 0.1 | GO:0061676 | importin-alpha family protein binding(GO:0061676) |
0.0 | 0.2 | GO:1990825 | sequence-specific mRNA binding(GO:1990825) |
0.0 | 0.1 | GO:0016427 | tRNA (cytosine) methyltransferase activity(GO:0016427) |
0.0 | 0.2 | GO:0097027 | ubiquitin-protein transferase activator activity(GO:0097027) |
0.0 | 0.5 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
0.0 | 0.9 | GO:0004004 | RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) |
0.0 | 0.3 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
0.0 | 1.0 | GO:0051082 | unfolded protein binding(GO:0051082) |
0.0 | 0.3 | GO:0017134 | fibroblast growth factor binding(GO:0017134) |
0.0 | 0.2 | GO:0070410 | co-SMAD binding(GO:0070410) |
0.0 | 0.6 | GO:0016706 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 3.1 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
0.1 | 0.8 | PID_TCR_JNK_PATHWAY | JNK signaling in the CD4+ TCR pathway |
0.0 | 0.6 | PID_INTEGRIN_CS_PATHWAY | Integrin family cell surface interactions |
0.0 | 0.6 | ST_WNT_CA2_CYCLIC_GMP_PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
0.0 | 0.8 | ST_MYOCYTE_AD_PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
0.0 | 0.9 | PID_HIF2PATHWAY | HIF-2-alpha transcription factor network |
0.0 | 0.9 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
0.0 | 0.5 | PID_INSULIN_GLUCOSE_PATHWAY | Insulin-mediated glucose transport |
0.0 | 0.9 | NABA_COLLAGENS | Genes encoding collagen proteins |
0.0 | 0.9 | PID_FOXO_PATHWAY | FoxO family signaling |
0.0 | 0.5 | PID_ATR_PATHWAY | ATR signaling pathway |
0.0 | 0.3 | PID_EPHA2_FWD_PATHWAY | EPHA2 forward signaling |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 2.8 | REACTOME_AMINE_DERIVED_HORMONES | Genes involved in Amine-derived hormones |
0.1 | 1.4 | REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
0.1 | 1.9 | REACTOME_EXTENSION_OF_TELOMERES | Genes involved in Extension of Telomeres |
0.1 | 1.1 | REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
0.1 | 0.8 | REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
0.1 | 0.7 | REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
0.0 | 0.6 | REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
0.0 | 0.9 | REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
0.0 | 0.5 | REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
0.0 | 0.4 | REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
0.0 | 0.9 | REACTOME_CGMP_EFFECTS | Genes involved in cGMP effects |
0.0 | 1.1 | REACTOME_PACKAGING_OF_TELOMERE_ENDS | Genes involved in Packaging Of Telomere Ends |
0.0 | 0.6 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
0.0 | 0.8 | REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
0.0 | 0.2 | REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
0.0 | 0.3 | REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
0.0 | 0.7 | REACTOME_GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
0.0 | 0.9 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
0.0 | 0.5 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
0.0 | 0.2 | REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
0.0 | 0.8 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
0.0 | 0.6 | REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
0.0 | 0.5 | REACTOME_INTERFERON_GAMMA_SIGNALING | Genes involved in Interferon gamma signaling |