Motif ID: Foxc1

Z-value: 1.202


Transcription factors associated with Foxc1:

Gene SymbolEntrez IDGene Name
Foxc1 ENSMUSG00000050295.2 Foxc1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxc1mm10_v2_chr13_+_31806627_318066500.204.3e-01Click!


Activity profile for motif Foxc1.

activity profile for motif Foxc1


Sorted Z-values histogram for motif Foxc1

Sorted Z-values for motif Foxc1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxc1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_60144682 4.304 ENSMUST00000065383.4
E330013P04Rik
RIKEN cDNA E330013P04 gene
chr14_-_48662740 3.775 ENSMUST00000122009.1
Otx2
orthodenticle homolog 2 (Drosophila)
chr1_+_72824482 3.710 ENSMUST00000047328.4
Igfbp2
insulin-like growth factor binding protein 2
chr1_+_84839833 3.621 ENSMUST00000097672.3
Fbxo36
F-box protein 36
chr1_+_45311538 3.579 ENSMUST00000087883.6
Col3a1
collagen, type III, alpha 1
chr6_+_47244359 3.344 ENSMUST00000060839.6
Cntnap2
contactin associated protein-like 2
chr17_-_70851710 3.116 ENSMUST00000166395.2
Tgif1
TGFB-induced factor homeobox 1
chrX_-_102251852 2.981 ENSMUST00000101336.3
ENSMUST00000136277.1
Cited1

Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1

chr7_-_75308373 2.929 ENSMUST00000085164.5
Sv2b
synaptic vesicle glycoprotein 2 b
chr1_+_107511489 2.906 ENSMUST00000064916.2
Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr1_+_107511416 2.815 ENSMUST00000009356.4
Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chrX_-_102252154 2.701 ENSMUST00000050551.3
Cited1
Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1
chr2_+_4976113 2.688 ENSMUST00000167607.1
ENSMUST00000115010.2
Ucma

upper zone of growth plate and cartilage matrix associated

chr17_+_80944611 2.685 ENSMUST00000025092.4
Tmem178
transmembrane protein 178
chr13_+_53525703 2.461 ENSMUST00000081132.4
Gm5449
predicted pseudogene 5449
chrY_+_1010543 2.321 ENSMUST00000091197.3
Eif2s3y
eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked
chr16_-_21947536 2.288 ENSMUST00000023562.7
Tmem41a
transmembrane protein 41a
chrX_-_109013389 1.992 ENSMUST00000033597.8
Hmgn5
high-mobility group nucleosome binding domain 5
chr10_+_77864623 1.951 ENSMUST00000092366.2
Tspear
thrombospondin type laminin G domain and EAR repeats
chr3_+_94377432 1.833 ENSMUST00000107292.1
Rorc
RAR-related orphan receptor gamma
chr8_+_106870827 1.821 ENSMUST00000176144.1
ENSMUST00000175987.1
Has3

hyaluronan synthase 3

chr15_-_102667749 1.779 ENSMUST00000075630.3
Atp5g2
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C2 (subunit 9)
chr9_-_106891401 1.779 ENSMUST00000069036.7
Manf
mesencephalic astrocyte-derived neurotrophic factor
chr11_-_78550777 1.745 ENSMUST00000103242.4
Tmem97
transmembrane protein 97
chr2_-_126709567 1.650 ENSMUST00000099423.2
Gm10774
predicted pseudogene 10774
chr18_+_78349754 1.631 ENSMUST00000164064.1
Gm6133
predicted gene 6133
chr4_-_43030440 1.628 ENSMUST00000135660.1
Stoml2
stomatin (Epb7.2)-like 2
chr12_-_69198419 1.537 ENSMUST00000021356.5
Dnaaf2
dynein, axonemal assembly factor 2
chr17_+_45686322 1.537 ENSMUST00000024734.7
Mrpl14
mitochondrial ribosomal protein L14
chr8_-_13494479 1.497 ENSMUST00000033828.5
Gas6
growth arrest specific 6
chr3_+_94377505 1.489 ENSMUST00000098877.2
Rorc
RAR-related orphan receptor gamma
chr2_-_172370506 1.435 ENSMUST00000109139.1
ENSMUST00000028997.7
ENSMUST00000109140.3
Aurka


aurora kinase A


chr11_-_98625661 1.426 ENSMUST00000104933.1
Gm12355
predicted gene 12355
chr7_-_127026479 1.425 ENSMUST00000032916.4
Maz
MYC-associated zinc finger protein (purine-binding transcription factor)
chr2_-_79908389 1.403 ENSMUST00000090756.4
Pde1a
phosphodiesterase 1A, calmodulin-dependent
chr3_+_37312514 1.385 ENSMUST00000057975.7
ENSMUST00000108121.3
Bbs12

Bardet-Biedl syndrome 12 (human)

chr9_+_72806874 1.344 ENSMUST00000055535.8
Prtg
protogenin homolog (Gallus gallus)
chr13_+_37826225 1.341 ENSMUST00000128570.1
Rreb1
ras responsive element binding protein 1
chr15_-_58034289 1.322 ENSMUST00000100655.3
9130401M01Rik
RIKEN cDNA 9130401M01 gene
chr12_-_73047179 1.291 ENSMUST00000050029.7
Six1
sine oculis-related homeobox 1
chr11_+_68968107 1.288 ENSMUST00000102606.3
ENSMUST00000018884.5
Slc25a35

solute carrier family 25, member 35

chr6_+_17281185 1.288 ENSMUST00000000058.6
Cav2
caveolin 2
chr16_-_46155077 1.283 ENSMUST00000059524.5
Gm4737
predicted gene 4737
chr6_+_86371489 1.245 ENSMUST00000089558.5
Snrpg
small nuclear ribonucleoprotein polypeptide G
chr1_-_131097535 1.227 ENSMUST00000016672.4
Mapkapk2
MAP kinase-activated protein kinase 2
chr16_-_59632520 1.219 ENSMUST00000118438.1
Arl6
ADP-ribosylation factor-like 6
chr17_-_36951338 1.162 ENSMUST00000173540.1
Ppp1r11
protein phosphatase 1, regulatory (inhibitor) subunit 11
chr5_+_98854434 1.159 ENSMUST00000031278.4
Bmp3
bone morphogenetic protein 3
chr4_+_98923810 1.154 ENSMUST00000030289.2
Usp1
ubiquitin specific peptidase 1
chr15_+_80255184 1.138 ENSMUST00000109605.3
Atf4
activating transcription factor 4
chr5_-_77115145 1.116 ENSMUST00000081964.5
Hopx
HOP homeobox
chr2_-_79908428 1.098 ENSMUST00000102652.3
ENSMUST00000102651.3
Pde1a

phosphodiesterase 1A, calmodulin-dependent

chr3_-_96197580 1.077 ENSMUST00000016087.3
Bola1
bolA-like 1 (E. coli)
chr10_+_115569986 1.049 ENSMUST00000173620.1
A930009A15Rik
RIKEN cDNA A930009A15 gene
chr3_-_141982224 1.043 ENSMUST00000029948.8
Bmpr1b
bone morphogenetic protein receptor, type 1B
chr4_-_116627478 1.024 ENSMUST00000081182.4
ENSMUST00000030457.5
Nasp

nuclear autoantigenic sperm protein (histone-binding)

chr11_+_73160403 1.002 ENSMUST00000006104.3
P2rx5
purinergic receptor P2X, ligand-gated ion channel, 5
chr5_+_8046077 0.994 ENSMUST00000088786.4
Sri
sorcin
chr9_-_71592265 0.990 ENSMUST00000169573.1
ENSMUST00000166843.1
ENSMUST00000163998.1
Myzap
Gcom1

myocardial zonula adherens protein
GRINL1A complex locus

chr4_+_98923845 0.987 ENSMUST00000091358.4
Usp1
ubiquitin specific peptidase 1
chr15_-_76656905 0.967 ENSMUST00000176274.1
Cyhr1
cysteine and histidine rich 1
chr17_-_36951636 0.967 ENSMUST00000040402.7
ENSMUST00000174711.1
Ppp1r11

protein phosphatase 1, regulatory (inhibitor) subunit 11

chr15_-_82244716 0.966 ENSMUST00000089155.4
ENSMUST00000089157.3
Cenpm

centromere protein M

chr4_-_40948196 0.966 ENSMUST00000030125.4
ENSMUST00000108089.1
Bag1

BCL2-associated athanogene 1

chr9_-_83146601 0.947 ENSMUST00000162246.2
ENSMUST00000161796.2
Hmgn3

high mobility group nucleosomal binding domain 3

chr3_+_95124476 0.940 ENSMUST00000131597.1
ENSMUST00000005769.6
ENSMUST00000107227.1
Tmod4


tropomodulin 4


chr1_+_75236439 0.929 ENSMUST00000082158.6
ENSMUST00000055223.7
Dnajb2

DnaJ (Hsp40) homolog, subfamily B, member 2

chr15_+_78597047 0.920 ENSMUST00000043069.5
Cyth4
cytohesin 4
chr5_-_100038869 0.906 ENSMUST00000153442.1
Hnrnpdl
heterogeneous nuclear ribonucleoprotein D-like
chr9_-_103222063 0.867 ENSMUST00000170904.1
Trf
transferrin
chr1_-_74284636 0.856 ENSMUST00000178235.1
ENSMUST00000006462.7
Aamp

angio-associated migratory protein

chr11_+_69935796 0.841 ENSMUST00000018698.5
Ybx2
Y box protein 2
chr3_-_89998656 0.831 ENSMUST00000079724.4
Hax1
HCLS1 associated X-1
chr1_-_87394721 0.830 ENSMUST00000113212.3
Kcnj13
potassium inwardly-rectifying channel, subfamily J, member 13
chr9_-_51278540 0.820 ENSMUST00000114427.3
Gm684
predicted gene 684
chr3_+_154597197 0.818 ENSMUST00000155385.1
ENSMUST00000029850.8
Cryz

crystallin, zeta

chr19_+_7268296 0.796 ENSMUST00000066646.4
Rcor2
REST corepressor 2
chr7_+_119760918 0.793 ENSMUST00000106527.1
ENSMUST00000106528.1
ENSMUST00000063770.3
ENSMUST00000106529.1
Acsm3



acyl-CoA synthetase medium-chain family member 3



chr13_-_107414742 0.788 ENSMUST00000061241.6
Apoo-ps
apolipoprotein O, pseudogene
chr3_+_124321031 0.781 ENSMUST00000058994.4
Tram1l1
translocation associated membrane protein 1-like 1
chr14_+_52016849 0.780 ENSMUST00000100638.2
Tmem253
transmembrane protein 253
chr1_+_74284930 0.777 ENSMUST00000113805.1
ENSMUST00000027370.6
ENSMUST00000087226.4
Pnkd


paroxysmal nonkinesiogenic dyskinesia


chr13_-_18382041 0.765 ENSMUST00000139064.2
ENSMUST00000175703.2
Pou6f2

POU domain, class 6, transcription factor 2

chr12_-_113422730 0.738 ENSMUST00000177715.1
ENSMUST00000103426.1
Ighm

immunoglobulin heavy constant mu

chr1_-_71653162 0.718 ENSMUST00000055226.6
Fn1
fibronectin 1
chr1_+_189728264 0.696 ENSMUST00000097442.2
Ptpn14
protein tyrosine phosphatase, non-receptor type 14
chr2_+_151542483 0.677 ENSMUST00000044011.5
Fkbp1a
FK506 binding protein 1a
chr2_-_156839790 0.671 ENSMUST00000134838.1
ENSMUST00000137463.1
ENSMUST00000149275.2
Gm14230


predicted gene 14230


chr13_+_65512678 0.668 ENSMUST00000081471.2
Gm10139
predicted gene 10139
chr3_+_90079540 0.667 ENSMUST00000029549.9
ENSMUST00000118566.1
ENSMUST00000119158.1
Tpm3


tropomyosin 3, gamma


chr15_+_80623499 0.632 ENSMUST00000043149.7
Grap2
GRB2-related adaptor protein 2
chr7_-_142656018 0.631 ENSMUST00000178921.1
Igf2
insulin-like growth factor 2
chr2_-_12301914 0.627 ENSMUST00000028106.4
Itga8
integrin alpha 8
chr11_+_6415443 0.624 ENSMUST00000132846.1
Ppia
peptidylprolyl isomerase A
chr6_+_68161415 0.619 ENSMUST00000168090.1
Igkv1-115
immunoglobulin kappa variable 1-115
chr4_-_116627921 0.609 ENSMUST00000030456.7
Nasp
nuclear autoantigenic sperm protein (histone-binding)
chr15_+_88819584 0.607 ENSMUST00000024042.3
Creld2
cysteine-rich with EGF-like domains 2
chr6_-_55175019 0.596 ENSMUST00000003569.5
Inmt
indolethylamine N-methyltransferase
chr18_+_53245618 0.592 ENSMUST00000165032.1
Snx24
sorting nexing 24
chr3_-_87263703 0.585 ENSMUST00000146512.1
Fcrls
Fc receptor-like S, scavenger receptor
chr5_-_149636164 0.564 ENSMUST00000076410.4
Hsph1
heat shock 105kDa/110kDa protein 1
chr3_-_57294880 0.558 ENSMUST00000171384.1
Tm4sf1
transmembrane 4 superfamily member 1
chr8_-_41417042 0.544 ENSMUST00000033999.6
Frg1
FSHD region gene 1
chr11_-_96829483 0.540 ENSMUST00000167149.1
Nfe2l1
nuclear factor, erythroid derived 2,-like 1
chr12_+_76370266 0.525 ENSMUST00000042779.3
Zbtb1
zinc finger and BTB domain containing 1
chr11_+_3202612 0.523 ENSMUST00000110049.1
Eif4enif1
eukaryotic translation initiation factor 4E nuclear import factor 1
chr4_+_40948401 0.519 ENSMUST00000030128.5
Chmp5
charged multivesicular body protein 5
chr9_-_67049143 0.515 ENSMUST00000113687.1
ENSMUST00000113693.1
ENSMUST00000113701.1
ENSMUST00000034928.5
ENSMUST00000113685.3
ENSMUST00000030185.4
ENSMUST00000050905.9
ENSMUST00000113705.1
ENSMUST00000113697.1
ENSMUST00000113707.2
Tpm1









tropomyosin 1, alpha









chr14_-_31640878 0.512 ENSMUST00000167066.1
ENSMUST00000127204.2
ENSMUST00000022437.8
Hacl1


2-hydroxyacyl-CoA lyase 1


chr7_-_89941084 0.508 ENSMUST00000075010.4
ENSMUST00000153470.1
l7Rn6

lethal, Chr 7, Rinchik 6

chr1_+_120602405 0.504 ENSMUST00000079721.7
En1
engrailed 1
chr2_-_103485068 0.500 ENSMUST00000111168.3
Cat
catalase
chr13_-_54766553 0.491 ENSMUST00000036825.7
Sncb
synuclein, beta
chr14_-_31128924 0.483 ENSMUST00000064032.4
ENSMUST00000049732.5
ENSMUST00000090205.3
Smim4


small itegral membrane protein 4


chr19_+_53944870 0.473 ENSMUST00000025932.7
Shoc2
soc-2 (suppressor of clear) homolog (C. elegans)
chr3_-_87263518 0.472 ENSMUST00000090986.4
Fcrls
Fc receptor-like S, scavenger receptor
chr19_-_53944621 0.464 ENSMUST00000135402.2
Bbip1
BBSome interacting protein 1
chr3_+_61364507 0.454 ENSMUST00000049064.2
Rap2b
RAP2B, member of RAS oncogene family
chr10_-_14705459 0.448 ENSMUST00000149485.1
ENSMUST00000154132.1
Vta1

Vps20-associated 1 homolog (S. cerevisiae)

chr2_+_30807826 0.429 ENSMUST00000041830.3
ENSMUST00000152374.1
Ntmt1

N-terminal Xaa-Pro-Lys N-methyltransferase 1

chr7_-_51862216 0.400 ENSMUST00000169357.1
Fancf
Fanconi anemia, complementation group F
chr17_+_16972910 0.389 ENSMUST00000071374.5
BC002059
cDNA sequence BC002059
chr2_+_163994960 0.387 ENSMUST00000018470.3
Ywhab
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
chr12_+_44328882 0.380 ENSMUST00000020939.8
ENSMUST00000110748.2
Nrcam

neuron-glia-CAM-related cell adhesion molecule

chr7_+_44816088 0.363 ENSMUST00000057195.9
ENSMUST00000107891.1
Nup62

nucleoporin 62

chr1_-_82291370 0.348 ENSMUST00000069799.2
Irs1
insulin receptor substrate 1
chr7_+_16309577 0.329 ENSMUST00000002152.6
Bbc3
BCL2 binding component 3
chrY_+_90843934 0.327 ENSMUST00000178550.1
Gm21742
predicted gene, 21742
chr12_+_4234023 0.320 ENSMUST00000179139.1
Ptrhd1
peptidyl-tRNA hydrolase domain containing 1
chr1_+_163994866 0.316 ENSMUST00000111490.1
ENSMUST00000045694.7
Mettl18

methyltransferase like 18

chr3_+_145987835 0.311 ENSMUST00000039517.6
Syde2
synapse defective 1, Rho GTPase, homolog 2 (C. elegans)
chr16_+_58727910 0.303 ENSMUST00000023426.5
ENSMUST00000162057.1
ENSMUST00000162191.1
Cldn25


claudin 25


chr18_-_33463615 0.293 ENSMUST00000051087.8
Nrep
neuronal regeneration related protein
chr17_-_45686214 0.291 ENSMUST00000113523.2
Tmem63b
transmembrane protein 63b
chr8_-_25840440 0.289 ENSMUST00000110609.1
Ash2l
ash2 (absent, small, or homeotic)-like (Drosophila)
chr4_-_59783800 0.284 ENSMUST00000107526.1
ENSMUST00000095063.4
Inip

INTS3 and NABP interacting protein

chr14_+_113314602 0.280 ENSMUST00000072359.6
Tpm3-rs7
tropomyosin 3, related sequence 7
chr2_-_76215363 0.260 ENSMUST00000144892.1
Pde11a
phosphodiesterase 11A
chr15_+_82016369 0.253 ENSMUST00000069530.6
Xrcc6
X-ray repair complementing defective repair in Chinese hamster cells 6
chr1_-_5019342 0.252 ENSMUST00000002533.8
Rgs20
regulator of G-protein signaling 20
chr6_-_29212240 0.241 ENSMUST00000160878.1
ENSMUST00000078155.5
Impdh1

inosine 5'-phosphate dehydrogenase 1

chr2_-_181365306 0.238 ENSMUST00000108808.1
ENSMUST00000170190.1
ENSMUST00000127988.1
Arfrp1


ADP-ribosylation factor related protein 1


chr14_+_67716095 0.229 ENSMUST00000078053.6
ENSMUST00000145542.1
ENSMUST00000125212.1
Kctd9


potassium channel tetramerisation domain containing 9


chr17_-_57011271 0.219 ENSMUST00000002733.6
Gtf2f1
general transcription factor IIF, polypeptide 1
chr11_-_96829959 0.208 ENSMUST00000081775.5
Nfe2l1
nuclear factor, erythroid derived 2,-like 1
chr3_+_154597352 0.200 ENSMUST00000140644.1
ENSMUST00000144764.1
ENSMUST00000155232.1
Cryz


crystallin, zeta


chr17_+_46254017 0.175 ENSMUST00000095262.4
Lrrc73
leucine rich repeat containing 73
chr7_-_44892358 0.170 ENSMUST00000003049.6
Med25
mediator of RNA polymerase II transcription, subunit 25 homolog (yeast)
chr11_-_74724670 0.161 ENSMUST00000021091.8
Pafah1b1
platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
chr18_+_58556224 0.151 ENSMUST00000025500.6
Slc27a6
solute carrier family 27 (fatty acid transporter), member 6
chr7_-_44816586 0.149 ENSMUST00000047356.8
Atf5
activating transcription factor 5
chr16_-_94370450 0.147 ENSMUST00000138514.1
Pigp
phosphatidylinositol glycan anchor biosynthesis, class P
chr15_+_6422240 0.141 ENSMUST00000163082.1
Dab2
disabled 2, mitogen-responsive phosphoprotein
chr11_+_101082565 0.135 ENSMUST00000001806.3
ENSMUST00000107308.3
Coasy

Coenzyme A synthase

chr1_+_34439851 0.129 ENSMUST00000027303.7
Imp4
IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast)
chr4_+_117550326 0.116 ENSMUST00000037127.8
Eri3
exoribonuclease 3
chr10_+_45577811 0.113 ENSMUST00000037044.6
Hace1
HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1
chr15_-_102257449 0.112 ENSMUST00000043172.8
Rarg
retinoic acid receptor, gamma
chr2_+_73312601 0.102 ENSMUST00000090811.4
ENSMUST00000112050.1
Scrn3

secernin 3

chr7_+_19228334 0.071 ENSMUST00000063976.8
Opa3
optic atrophy 3
chr14_+_31641051 0.070 ENSMUST00000090147.6
Btd
biotinidase
chr11_-_102296618 0.064 ENSMUST00000107132.2
ENSMUST00000073234.2
Atxn7l3

ataxin 7-like 3

chr5_-_97111565 0.032 ENSMUST00000112969.3
Paqr3
progestin and adipoQ receptor family member III
chr15_-_78405824 0.029 ENSMUST00000058659.7
Tst
thiosulfate sulfurtransferase, mitochondrial
chr2_-_26140468 0.022 ENSMUST00000133808.1
C330006A16Rik
RIKEN cDNA C330006A16 gene
chr6_+_55203381 0.002 ENSMUST00000053094.7
Fam188b
family with sequence similarity 188, member B
chr4_+_11123950 0.001 ENSMUST00000142297.1
Gm11827
predicted gene 11827

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 5.7 GO:0071105 response to interleukin-9(GO:0071104) response to interleukin-11(GO:0071105)
0.9 3.8 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.7 3.6 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.7 3.3 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.6 1.8 GO:0036118 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.6 1.8 GO:0002014 vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure(GO:0002014)
0.5 1.6 GO:1990046 positive regulation of mitochondrial DNA replication(GO:0090297) regulation of cardiolipin metabolic process(GO:1900208) positive regulation of cardiolipin metabolic process(GO:1900210) stress-induced mitochondrial fusion(GO:1990046)
0.5 1.5 GO:0003104 positive regulation of glomerular filtration(GO:0003104) negative regulation of protein import into nucleus, translocation(GO:0033159) regulation of oligodendrocyte apoptotic process(GO:1900141) negative regulation of oligodendrocyte apoptotic process(GO:1900142) positive regulation of dendritic cell chemotaxis(GO:2000510)
0.4 1.3 GO:0008582 regulation of synaptic growth at neuromuscular junction(GO:0008582)
0.4 3.3 GO:0072615 interleukin-17 secretion(GO:0072615)
0.4 1.4 GO:0007056 spindle assembly involved in female meiosis(GO:0007056) positive regulation of oocyte development(GO:0060282)
0.3 0.9 GO:1903644 regulation of chaperone-mediated protein folding(GO:1903644)
0.3 1.2 GO:0046909 intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445)
0.3 2.1 GO:0043416 regulation of skeletal muscle tissue regeneration(GO:0043416)
0.3 1.1 GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)
0.3 1.0 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.2 0.7 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931) calcium-independent cell-matrix adhesion(GO:0007161) transforming growth factor-beta secretion(GO:0038044)
0.2 3.7 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.2 1.3 GO:0060161 positive regulation of dopamine receptor signaling pathway(GO:0060161)
0.2 2.1 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.2 3.1 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.2 1.2 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535) macropinocytosis(GO:0044351)
0.2 1.4 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.2 1.0 GO:0055118 negative regulation of cardiac muscle contraction(GO:0055118)
0.2 1.0 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.2 2.8 GO:0046069 cGMP catabolic process(GO:0046069)
0.2 1.0 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.2 0.9 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.2 0.5 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.1 2.7 GO:0045671 negative regulation of osteoclast differentiation(GO:0045671)
0.1 1.3 GO:2000394 positive regulation of lamellipodium morphogenesis(GO:2000394)
0.1 2.8 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.1 0.7 GO:0002339 B cell selection(GO:0002339)
0.1 0.6 GO:0045343 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343) positive regulation of MHC class I biosynthetic process(GO:0045345) positive regulation of NK T cell activation(GO:0051135)
0.1 0.5 GO:0002572 pro-T cell differentiation(GO:0002572)
0.1 0.5 GO:0061743 motor learning(GO:0061743)
0.1 0.4 GO:1903490 regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490)
0.1 0.8 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.1 0.9 GO:0098707 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.1 0.4 GO:0018201 peptidyl-glycine modification(GO:0018201)
0.1 0.5 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.1 0.5 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
0.1 0.3 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.1 0.6 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.1 0.8 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.1 1.5 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.1 1.6 GO:0043486 histone exchange(GO:0043486)
0.1 0.3 GO:0090273 regulation of somatostatin secretion(GO:0090273)
0.1 1.8 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 0.4 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.1 1.0 GO:0042178 xenobiotic catabolic process(GO:0042178)
0.1 1.4 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.0 0.2 GO:0006177 GMP biosynthetic process(GO:0006177)
0.0 0.5 GO:0009650 UV protection(GO:0009650)
0.0 0.7 GO:0001946 lymphangiogenesis(GO:0001946)
0.0 1.9 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.0 0.9 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.5 GO:0032486 Rap protein signal transduction(GO:0032486)
0.0 5.7 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.0 0.6 GO:0034389 lipid particle organization(GO:0034389)
0.0 0.2 GO:0051661 maintenance of centrosome location(GO:0051661)
0.0 1.3 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.0 1.3 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.8 GO:0010107 potassium ion import(GO:0010107)
0.0 1.7 GO:0042632 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.0 0.6 GO:1903846 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.0 0.8 GO:0048255 mRNA stabilization(GO:0048255)
0.0 0.3 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.5 GO:0042417 dopamine metabolic process(GO:0042417)
0.0 2.0 GO:0007605 sensory perception of sound(GO:0007605)
0.0 0.1 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 1.5 GO:0006413 translational initiation(GO:0006413)
0.0 0.9 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
0.0 0.1 GO:0021891 olfactory bulb interneuron development(GO:0021891)
0.0 0.2 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.0 0.6 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 0.8 GO:0035383 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0042585 germinal vesicle(GO:0042585)
0.3 1.0 GO:0042584 chromaffin granule membrane(GO:0042584)
0.3 3.6 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.3 1.1 GO:1990590 ATF1-ATF4 transcription factor complex(GO:1990590)
0.2 0.7 GO:0005577 fibrinogen complex(GO:0005577)
0.2 2.6 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.2 0.7 GO:0019815 B cell receptor complex(GO:0019815)
0.2 1.2 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.1 1.8 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 1.6 GO:0042101 T cell receptor complex(GO:0042101)
0.1 0.3 GO:0005899 insulin receptor complex(GO:0005899)
0.1 1.4 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.1 0.9 GO:0097433 dense body(GO:0097433)
0.1 1.2 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 2.7 GO:0030673 axolemma(GO:0030673)
0.1 1.3 GO:0002080 acrosomal membrane(GO:0002080)
0.1 0.6 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 0.9 GO:0005865 striated muscle thin filament(GO:0005865)
0.1 1.0 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.1 0.3 GO:0070876 SOSS complex(GO:0070876)
0.1 2.7 GO:0016235 aggresome(GO:0016235)
0.0 0.5 GO:0034464 BBSome(GO:0034464)
0.0 0.4 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.0 2.1 GO:0032420 stereocilium(GO:0032420)
0.0 0.1 GO:0034457 Mpp10 complex(GO:0034457)
0.0 0.4 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.1 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.7 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 1.4 GO:0016234 inclusion body(GO:0016234)
0.0 1.5 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.3 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 1.3 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 1.4 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.9 GO:0045171 intercellular bridge(GO:0045171)
0.0 1.0 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 15.9 GO:0005615 extracellular space(GO:0005615)
0.0 2.2 GO:0001650 fibrillar center(GO:0001650)
0.0 1.5 GO:0036064 ciliary basal body(GO:0036064)
0.0 0.4 GO:0043194 axon initial segment(GO:0043194)
0.0 1.2 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 1.1 GO:0043195 terminal bouton(GO:0043195)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.3 GO:0008142 oxysterol binding(GO:0008142)
0.6 1.8 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.5 5.7 GO:0050693 LBD domain binding(GO:0050693)
0.5 3.7 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.4 2.5 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.3 1.4 GO:0035174 histone serine kinase activity(GO:0035174)
0.3 0.8 GO:0019966 interleukin-1 binding(GO:0019966)
0.3 2.1 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.3 0.8 GO:0003996 acyl-CoA ligase activity(GO:0003996)
0.2 3.6 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.2 1.6 GO:1901612 phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)
0.2 1.5 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.2 1.0 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.2 3.1 GO:0070410 co-SMAD binding(GO:0070410)
0.1 0.7 GO:0045340 mercury ion binding(GO:0045340)
0.1 1.2 GO:1990446 U1 snRNP binding(GO:1990446)
0.1 5.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 0.5 GO:0004096 aminoacylase activity(GO:0004046) catalase activity(GO:0004096)
0.1 0.9 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.1 0.4 GO:0051425 PTB domain binding(GO:0051425)
0.1 0.6 GO:0008172 S-methyltransferase activity(GO:0008172)
0.1 0.9 GO:0005523 tropomyosin binding(GO:0005523)
0.1 1.0 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 1.2 GO:0070700 BMP receptor binding(GO:0070700)
0.1 1.5 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.1 1.8 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 1.2 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 0.9 GO:0034046 poly(G) binding(GO:0034046)
0.1 1.1 GO:0043522 leucine zipper domain binding(GO:0043522)
0.1 0.6 GO:0016018 cyclosporin A binding(GO:0016018)
0.1 0.8 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.1 0.7 GO:0048185 activin binding(GO:0048185)
0.1 0.3 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.1 0.4 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.1 0.5 GO:1903136 cuprous ion binding(GO:1903136)
0.1 0.2 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.1 2.9 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 0.3 GO:1990188 euchromatin binding(GO:1990188)
0.1 0.5 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.1 1.0 GO:0070402 NADPH binding(GO:0070402)
0.0 1.3 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.7 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.6 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.1 GO:0004140 dephospho-CoA kinase activity(GO:0004140)
0.0 0.2 GO:0019211 phosphatase activator activity(GO:0019211)
0.0 4.4 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 0.1 GO:0030519 snoRNP binding(GO:0030519)
0.0 0.9 GO:0070628 proteasome binding(GO:0070628)
0.0 1.4 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.8 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 2.8 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 4.3 GO:0002020 protease binding(GO:0002020)
0.0 0.3 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.0 1.6 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 0.4 GO:0050815 phosphoserine binding(GO:0050815)
0.0 0.3 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 1.2 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.9 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 2.4 GO:0008083 growth factor activity(GO:0008083)
0.0 1.6 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 1.6 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.5 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.7 GO:0045182 translation regulator activity(GO:0045182)
0.0 0.7 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 1.4 GO:0051219 phosphoprotein binding(GO:0051219)
0.0 0.2 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.1 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.9 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.6 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.1 GO:0035612 AP-2 adaptor complex binding(GO:0035612)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.6 NABA_COLLAGENS Genes encoding collagen proteins
0.1 8.8 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 0.7 PID_ALK2_PATHWAY ALK2 signaling events
0.1 2.0 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.1 0.6 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 7.6 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.5 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 1.6 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.6 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.0 1.1 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.4 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 5.2 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.0 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.0 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 0.3 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.0 0.5 PID_FOXO_PATHWAY FoxO family signaling
0.0 0.6 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.3 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2 2.1 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.1 1.1 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 1.8 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.1 2.8 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 3.1 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 0.6 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1 3.6 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 0.8 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.1 1.2 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events
0.1 0.7 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 3.2 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.2 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.5 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.0 1.0 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 1.0 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.7 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.4 REACTOME_RAF_MAP_KINASE_CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.6 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.4 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
0.0 0.6 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 1.4 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.0 0.2 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.5 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.4 REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 0.3 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.0 0.3 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.2 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 1.1 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 5.1 REACTOME_HEMOSTASIS Genes involved in Hemostasis
0.0 0.4 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins