Motif ID: Atf6
Z-value: 1.231

Transcription factors associated with Atf6:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Atf6 | ENSMUSG00000026663.6 | Atf6 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Atf6 | mm10_v2_chr1_-_170867761_170867784 | -0.18 | 4.8e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.1 | 3.4 | GO:0043379 | memory T cell differentiation(GO:0043379) negative regulation of isotype switching to IgE isotypes(GO:0048294) |
0.7 | 5.3 | GO:0071557 | histone H3-K27 demethylation(GO:0071557) |
0.4 | 2.2 | GO:1900748 | positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748) |
0.4 | 1.3 | GO:0010360 | negative regulation of anion channel activity(GO:0010360) |
0.3 | 1.0 | GO:0070343 | white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350) |
0.3 | 1.4 | GO:0099566 | regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566) |
0.3 | 2.5 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
0.3 | 0.9 | GO:0060478 | acrosomal vesicle exocytosis(GO:0060478) |
0.3 | 1.6 | GO:0060075 | regulation of resting membrane potential(GO:0060075) |
0.3 | 3.6 | GO:0090110 | cargo loading into COPII-coated vesicle(GO:0090110) |
0.3 | 0.8 | GO:0035523 | protein K29-linked deubiquitination(GO:0035523) |
0.3 | 1.0 | GO:0035609 | C-terminal protein deglutamylation(GO:0035609) |
0.2 | 0.7 | GO:0009298 | GDP-mannose biosynthetic process(GO:0009298) |
0.2 | 1.0 | GO:0072531 | pyrimidine-containing compound transmembrane transport(GO:0072531) |
0.2 | 0.7 | GO:1902630 | regulation of membrane hyperpolarization(GO:1902630) |
0.2 | 1.3 | GO:0019695 | choline metabolic process(GO:0019695) |
0.2 | 0.6 | GO:0090204 | protein localization to nuclear pore(GO:0090204) |
0.2 | 0.6 | GO:0070375 | ERK5 cascade(GO:0070375) |
0.2 | 0.9 | GO:1901843 | positive regulation of high voltage-gated calcium channel activity(GO:1901843) |
0.2 | 3.3 | GO:0002115 | store-operated calcium entry(GO:0002115) |
0.2 | 2.1 | GO:0006995 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
0.2 | 0.7 | GO:0070358 | actin polymerization-dependent cell motility(GO:0070358) |
0.2 | 0.5 | GO:0003195 | tricuspid valve formation(GO:0003195) right ventricular cardiac muscle tissue morphogenesis(GO:0003221) |
0.2 | 0.7 | GO:0045113 | regulation of integrin biosynthetic process(GO:0045113) |
0.2 | 0.5 | GO:0010248 | B cell negative selection(GO:0002352) establishment or maintenance of transmembrane electrochemical gradient(GO:0010248) regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445) |
0.1 | 0.6 | GO:0016340 | calcium-dependent cell-matrix adhesion(GO:0016340) |
0.1 | 1.8 | GO:0044387 | negative regulation of protein kinase activity by regulation of protein phosphorylation(GO:0044387) |
0.1 | 1.3 | GO:0006682 | galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375) |
0.1 | 1.0 | GO:0060315 | response to redox state(GO:0051775) negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315) |
0.1 | 1.0 | GO:1990573 | potassium ion import across plasma membrane(GO:1990573) |
0.1 | 0.6 | GO:0071638 | negative regulation of monocyte chemotactic protein-1 production(GO:0071638) |
0.1 | 0.4 | GO:1902219 | negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219) |
0.1 | 1.1 | GO:2000301 | negative regulation of synaptic vesicle exocytosis(GO:2000301) |
0.1 | 3.2 | GO:0002091 | negative regulation of receptor internalization(GO:0002091) |
0.1 | 0.4 | GO:1902528 | regulation of protein linear polyubiquitination(GO:1902528) positive regulation of protein linear polyubiquitination(GO:1902530) |
0.1 | 1.1 | GO:0098907 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) regulation of SA node cell action potential(GO:0098907) |
0.1 | 3.0 | GO:0090036 | regulation of protein kinase C signaling(GO:0090036) |
0.1 | 3.0 | GO:0043496 | regulation of protein homodimerization activity(GO:0043496) |
0.1 | 0.3 | GO:0034035 | sulfate assimilation(GO:0000103) purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427) |
0.1 | 0.4 | GO:1901678 | iron coordination entity transport(GO:1901678) |
0.1 | 0.4 | GO:0010756 | positive regulation of plasminogen activation(GO:0010756) |
0.1 | 0.4 | GO:0060266 | positive regulation of respiratory burst involved in inflammatory response(GO:0060265) negative regulation of respiratory burst involved in inflammatory response(GO:0060266) |
0.1 | 0.3 | GO:0071492 | cellular response to UV-A(GO:0071492) |
0.1 | 0.6 | GO:0002904 | positive regulation of B cell apoptotic process(GO:0002904) |
0.1 | 1.0 | GO:1902474 | positive regulation of protein localization to synapse(GO:1902474) |
0.1 | 0.2 | GO:0048496 | maintenance of organ identity(GO:0048496) |
0.1 | 0.7 | GO:0090166 | Golgi disassembly(GO:0090166) |
0.1 | 1.0 | GO:0045176 | apical protein localization(GO:0045176) |
0.1 | 0.5 | GO:1990416 | positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) cellular response to brain-derived neurotrophic factor stimulus(GO:1990416) |
0.1 | 0.9 | GO:0032808 | lacrimal gland development(GO:0032808) |
0.1 | 0.6 | GO:0051503 | adenine nucleotide transport(GO:0051503) |
0.1 | 0.4 | GO:0032811 | negative regulation of epinephrine secretion(GO:0032811) |
0.1 | 0.4 | GO:2000672 | negative regulation of motor neuron apoptotic process(GO:2000672) |
0.1 | 1.1 | GO:0035641 | locomotory exploration behavior(GO:0035641) |
0.1 | 3.9 | GO:0007528 | neuromuscular junction development(GO:0007528) |
0.1 | 0.3 | GO:1902031 | regulation of NADP metabolic process(GO:1902031) |
0.1 | 0.7 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
0.1 | 0.4 | GO:0006102 | isocitrate metabolic process(GO:0006102) |
0.1 | 0.4 | GO:0016480 | negative regulation of transcription from RNA polymerase III promoter(GO:0016480) |
0.1 | 0.2 | GO:0015747 | urate transport(GO:0015747) |
0.1 | 0.2 | GO:0006646 | phosphatidylethanolamine biosynthetic process(GO:0006646) |
0.1 | 1.4 | GO:0060416 | response to growth hormone(GO:0060416) |
0.1 | 0.2 | GO:1902527 | positive regulation of protein monoubiquitination(GO:1902527) |
0.1 | 0.2 | GO:0051495 | positive regulation of cytoskeleton organization(GO:0051495) |
0.1 | 0.5 | GO:0048680 | positive regulation of axon regeneration(GO:0048680) |
0.1 | 0.6 | GO:0043084 | penile erection(GO:0043084) |
0.1 | 0.2 | GO:0032916 | transforming growth factor beta3 production(GO:0032907) regulation of transforming growth factor beta3 production(GO:0032910) positive regulation of transforming growth factor beta3 production(GO:0032916) |
0.1 | 0.3 | GO:0044828 | negative regulation by host of viral genome replication(GO:0044828) |
0.0 | 0.1 | GO:0009826 | unidimensional cell growth(GO:0009826) |
0.0 | 0.8 | GO:0042659 | regulation of cell fate specification(GO:0042659) |
0.0 | 0.3 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
0.0 | 2.1 | GO:0006506 | GPI anchor biosynthetic process(GO:0006506) |
0.0 | 0.8 | GO:0007289 | spermatid nucleus differentiation(GO:0007289) |
0.0 | 2.0 | GO:0001919 | regulation of receptor recycling(GO:0001919) |
0.0 | 0.4 | GO:0098712 | L-glutamate import across plasma membrane(GO:0098712) |
0.0 | 0.7 | GO:0060746 | parental behavior(GO:0060746) |
0.0 | 0.8 | GO:0071577 | zinc II ion transmembrane transport(GO:0071577) |
0.0 | 0.2 | GO:0009405 | pathogenesis(GO:0009405) |
0.0 | 0.5 | GO:0060628 | regulation of ER to Golgi vesicle-mediated transport(GO:0060628) |
0.0 | 0.3 | GO:1904781 | positive regulation of protein localization to centrosome(GO:1904781) |
0.0 | 0.3 | GO:0046541 | saliva secretion(GO:0046541) |
0.0 | 0.3 | GO:0000395 | mRNA 5'-splice site recognition(GO:0000395) |
0.0 | 0.3 | GO:0061635 | regulation of protein complex stability(GO:0061635) |
0.0 | 0.1 | GO:0060729 | intestinal epithelial structure maintenance(GO:0060729) |
0.0 | 0.2 | GO:0021993 | initiation of neural tube closure(GO:0021993) |
0.0 | 0.4 | GO:0044144 | regulation of growth of symbiont in host(GO:0044126) modulation of growth of symbiont involved in interaction with host(GO:0044144) |
0.0 | 0.2 | GO:0030578 | PML body organization(GO:0030578) |
0.0 | 0.1 | GO:0006616 | SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616) |
0.0 | 0.9 | GO:0007094 | mitotic spindle assembly checkpoint(GO:0007094) spindle assembly checkpoint(GO:0071173) |
0.0 | 0.5 | GO:2000311 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311) |
0.0 | 0.5 | GO:0043968 | histone H2A acetylation(GO:0043968) |
0.0 | 0.2 | GO:0015074 | DNA integration(GO:0015074) |
0.0 | 0.2 | GO:0006620 | posttranslational protein targeting to membrane(GO:0006620) |
0.0 | 0.1 | GO:1901072 | glucosamine-containing compound catabolic process(GO:1901072) |
0.0 | 0.4 | GO:0007614 | short-term memory(GO:0007614) |
0.0 | 0.3 | GO:0030828 | positive regulation of cGMP biosynthetic process(GO:0030828) |
0.0 | 0.2 | GO:0032510 | endosome to lysosome transport via multivesicular body sorting pathway(GO:0032510) |
0.0 | 0.5 | GO:0070536 | protein K63-linked deubiquitination(GO:0070536) |
0.0 | 1.3 | GO:0036465 | synaptic vesicle recycling(GO:0036465) |
0.0 | 0.2 | GO:0000712 | resolution of meiotic recombination intermediates(GO:0000712) |
0.0 | 0.2 | GO:0009312 | oligosaccharide biosynthetic process(GO:0009312) |
0.0 | 0.1 | GO:0030043 | actin filament fragmentation(GO:0030043) |
0.0 | 0.2 | GO:0075522 | IRES-dependent viral translational initiation(GO:0075522) |
0.0 | 0.1 | GO:0060770 | negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770) |
0.0 | 0.6 | GO:0032292 | myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292) |
0.0 | 0.2 | GO:2000580 | positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582) |
0.0 | 0.1 | GO:0031642 | negative regulation of myelination(GO:0031642) negative regulation of translation in response to stress(GO:0032055) cellular response to cold(GO:0070417) |
0.0 | 0.1 | GO:0009268 | response to pH(GO:0009268) |
0.0 | 0.8 | GO:0015914 | phospholipid transport(GO:0015914) |
0.0 | 0.2 | GO:0043982 | histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982) |
0.0 | 0.2 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
0.0 | 0.2 | GO:0061179 | negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179) |
0.0 | 0.1 | GO:0021886 | female meiosis I(GO:0007144) hypothalamus gonadotrophin-releasing hormone neuron differentiation(GO:0021886) hypothalamus gonadotrophin-releasing hormone neuron development(GO:0021888) |
0.0 | 0.2 | GO:1990403 | embryonic brain development(GO:1990403) |
0.0 | 0.3 | GO:0031290 | retinal ganglion cell axon guidance(GO:0031290) |
0.0 | 0.1 | GO:0006488 | dolichol-linked oligosaccharide biosynthetic process(GO:0006488) |
0.0 | 0.1 | GO:0048742 | regulation of skeletal muscle fiber development(GO:0048742) |
0.0 | 0.5 | GO:0045746 | negative regulation of Notch signaling pathway(GO:0045746) |
0.0 | 0.0 | GO:1903774 | positive regulation of viral budding via host ESCRT complex(GO:1903774) |
0.0 | 0.5 | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I(GO:0002474) |
0.0 | 0.3 | GO:0035025 | positive regulation of Rho protein signal transduction(GO:0035025) |
0.0 | 1.7 | GO:0071805 | potassium ion transmembrane transport(GO:0071805) |
0.0 | 0.6 | GO:0001707 | mesoderm formation(GO:0001707) |
0.0 | 0.3 | GO:0015991 | ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662) |
0.0 | 0.2 | GO:0010758 | regulation of macrophage chemotaxis(GO:0010758) |
0.0 | 0.1 | GO:0050774 | negative regulation of dendrite morphogenesis(GO:0050774) |
0.0 | 0.1 | GO:0006613 | cotranslational protein targeting to membrane(GO:0006613) |
0.0 | 5.4 | GO:0007186 | G-protein coupled receptor signaling pathway(GO:0007186) |
0.0 | 0.1 | GO:0034162 | toll-like receptor 9 signaling pathway(GO:0034162) |
0.0 | 0.0 | GO:0097709 | connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709) |
0.0 | 0.9 | GO:0030433 | ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) |
0.0 | 0.3 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 1.9 | GO:1902937 | inward rectifier potassium channel complex(GO:1902937) |
0.3 | 4.5 | GO:0043083 | synaptic cleft(GO:0043083) |
0.2 | 1.2 | GO:0005784 | Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256) |
0.2 | 3.5 | GO:0030127 | COPII vesicle coat(GO:0030127) |
0.2 | 1.5 | GO:0005827 | polar microtubule(GO:0005827) |
0.1 | 2.1 | GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506) |
0.1 | 2.5 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
0.1 | 4.7 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
0.1 | 0.5 | GO:0001652 | granular component(GO:0001652) |
0.1 | 2.1 | GO:0000421 | autophagosome membrane(GO:0000421) |
0.1 | 0.4 | GO:0070044 | synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044) |
0.1 | 0.4 | GO:0038039 | G-protein coupled receptor heterodimeric complex(GO:0038039) |
0.1 | 0.3 | GO:0099569 | presynaptic cytoskeleton(GO:0099569) |
0.1 | 3.4 | GO:0043034 | costamere(GO:0043034) |
0.1 | 1.1 | GO:0097449 | astrocyte projection(GO:0097449) |
0.1 | 0.5 | GO:0060053 | neurofilament cytoskeleton(GO:0060053) |
0.1 | 0.6 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
0.1 | 0.4 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
0.1 | 4.7 | GO:0031594 | neuromuscular junction(GO:0031594) |
0.0 | 1.9 | GO:0031201 | SNARE complex(GO:0031201) |
0.0 | 0.4 | GO:0000813 | ESCRT I complex(GO:0000813) |
0.0 | 0.5 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
0.0 | 0.9 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
0.0 | 2.8 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
0.0 | 0.0 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
0.0 | 3.2 | GO:0005657 | replication fork(GO:0005657) |
0.0 | 3.3 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
0.0 | 0.5 | GO:0032279 | asymmetric synapse(GO:0032279) |
0.0 | 0.4 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
0.0 | 0.3 | GO:0033179 | proton-transporting V-type ATPase, V0 domain(GO:0033179) |
0.0 | 0.1 | GO:0070985 | TFIIK complex(GO:0070985) |
0.0 | 0.1 | GO:0045334 | clathrin-coated endocytic vesicle(GO:0045334) |
0.0 | 0.2 | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541) |
0.0 | 0.2 | GO:0072357 | PTW/PP1 phosphatase complex(GO:0072357) |
0.0 | 0.3 | GO:0017119 | Golgi transport complex(GO:0017119) |
0.0 | 0.8 | GO:0035371 | microtubule plus-end(GO:0035371) |
0.0 | 0.2 | GO:0043240 | Fanconi anaemia nuclear complex(GO:0043240) |
0.0 | 0.2 | GO:0016272 | prefoldin complex(GO:0016272) |
0.0 | 0.2 | GO:1990316 | ATG1/ULK1 kinase complex(GO:1990316) |
0.0 | 1.0 | GO:0034704 | calcium channel complex(GO:0034704) |
0.0 | 4.4 | GO:0030426 | growth cone(GO:0030426) |
0.0 | 0.1 | GO:0005964 | phosphorylase kinase complex(GO:0005964) |
0.0 | 0.1 | GO:0070847 | core mediator complex(GO:0070847) |
0.0 | 0.4 | GO:0043189 | NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562) |
0.0 | 1.3 | GO:0005905 | clathrin-coated pit(GO:0005905) |
0.0 | 0.1 | GO:0005786 | signal recognition particle, endoplasmic reticulum targeting(GO:0005786) |
0.0 | 0.9 | GO:0000123 | histone acetyltransferase complex(GO:0000123) |
0.0 | 0.6 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.8 | 5.3 | GO:0071558 | histone demethylase activity (H3-K27 specific)(GO:0071558) |
0.4 | 1.5 | GO:0005483 | soluble NSF attachment protein activity(GO:0005483) |
0.4 | 1.1 | GO:0004698 | calcium-dependent protein kinase C activity(GO:0004698) |
0.3 | 1.3 | GO:0047275 | glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275) |
0.3 | 1.3 | GO:0004104 | cholinesterase activity(GO:0004104) choline binding(GO:0033265) |
0.3 | 2.2 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
0.3 | 3.4 | GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) |
0.3 | 1.1 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
0.2 | 1.4 | GO:0099583 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583) |
0.2 | 1.1 | GO:0008269 | JAK pathway signal transduction adaptor activity(GO:0008269) |
0.2 | 1.0 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
0.2 | 2.3 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
0.2 | 0.6 | GO:0046964 | 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity(GO:0046964) |
0.2 | 1.8 | GO:0017176 | phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176) |
0.2 | 1.3 | GO:0008429 | phosphatidylethanolamine binding(GO:0008429) |
0.2 | 1.7 | GO:0031802 | type 5 metabotropic glutamate receptor binding(GO:0031802) |
0.1 | 1.6 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
0.1 | 0.4 | GO:0004449 | isocitrate dehydrogenase (NAD+) activity(GO:0004449) |
0.1 | 0.6 | GO:0005111 | type 2 fibroblast growth factor receptor binding(GO:0005111) |
0.1 | 0.4 | GO:0005128 | erythropoietin receptor binding(GO:0005128) |
0.1 | 0.6 | GO:0045545 | syndecan binding(GO:0045545) |
0.1 | 0.2 | GO:0004103 | choline kinase activity(GO:0004103) |
0.1 | 0.5 | GO:0070012 | oligopeptidase activity(GO:0070012) |
0.1 | 1.9 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
0.1 | 0.3 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
0.1 | 0.3 | GO:0004473 | malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473) |
0.1 | 1.8 | GO:0097371 | MDM2/MDM4 family protein binding(GO:0097371) |
0.1 | 0.6 | GO:0042030 | ATPase inhibitor activity(GO:0042030) |
0.1 | 0.3 | GO:0005436 | sodium:phosphate symporter activity(GO:0005436) sodium:inorganic phosphate symporter activity(GO:0015319) |
0.1 | 0.3 | GO:0030249 | guanylate cyclase regulator activity(GO:0030249) |
0.1 | 0.5 | GO:0005030 | neurotrophin receptor activity(GO:0005030) |
0.1 | 0.4 | GO:0051434 | BH3 domain binding(GO:0051434) |
0.1 | 1.0 | GO:0019855 | calcium channel inhibitor activity(GO:0019855) |
0.1 | 0.5 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
0.1 | 0.4 | GO:0004965 | G-protein coupled GABA receptor activity(GO:0004965) |
0.1 | 0.8 | GO:0008526 | phosphatidylinositol transporter activity(GO:0008526) |
0.1 | 0.2 | GO:0042954 | lipoprotein transporter activity(GO:0042954) |
0.1 | 3.1 | GO:0005158 | insulin receptor binding(GO:0005158) |
0.1 | 0.2 | GO:0004582 | dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582) |
0.1 | 0.7 | GO:0016868 | intramolecular transferase activity, phosphotransferases(GO:0016868) |
0.1 | 0.7 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
0.1 | 0.9 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
0.1 | 0.7 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
0.1 | 0.2 | GO:0001225 | RNA polymerase II transcription coactivator binding(GO:0001225) |
0.0 | 0.3 | GO:0044547 | DNA topoisomerase binding(GO:0044547) |
0.0 | 0.3 | GO:0030375 | thyroid hormone receptor coactivator activity(GO:0030375) |
0.0 | 0.2 | GO:0004594 | pantothenate kinase activity(GO:0004594) |
0.0 | 0.2 | GO:0015143 | urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702) |
0.0 | 1.0 | GO:0015215 | nucleotide transmembrane transporter activity(GO:0015215) |
0.0 | 0.3 | GO:0031811 | G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812) |
0.0 | 0.8 | GO:0050811 | GABA receptor binding(GO:0050811) |
0.0 | 0.3 | GO:0016018 | cyclosporin A binding(GO:0016018) |
0.0 | 0.5 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
0.0 | 0.3 | GO:0050291 | sphingosine N-acyltransferase activity(GO:0050291) |
0.0 | 0.8 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
0.0 | 3.4 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
0.0 | 1.3 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
0.0 | 0.6 | GO:0004190 | aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001) |
0.0 | 0.2 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
0.0 | 0.3 | GO:1990239 | steroid hormone binding(GO:1990239) |
0.0 | 0.8 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
0.0 | 0.6 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
0.0 | 0.3 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
0.0 | 0.4 | GO:0005314 | high-affinity glutamate transmembrane transporter activity(GO:0005314) |
0.0 | 0.1 | GO:0000033 | alpha-1,3-mannosyltransferase activity(GO:0000033) |
0.0 | 0.6 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
0.0 | 0.6 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
0.0 | 0.4 | GO:0015248 | sterol transporter activity(GO:0015248) |
0.0 | 2.8 | GO:0000149 | SNARE binding(GO:0000149) |
0.0 | 0.3 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
0.0 | 1.1 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
0.0 | 0.1 | GO:0042043 | neurexin family protein binding(GO:0042043) |
0.0 | 0.2 | GO:0043995 | histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972) |
0.0 | 0.4 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
0.0 | 0.2 | GO:0015643 | toxic substance binding(GO:0015643) |
0.0 | 0.6 | GO:0017134 | fibroblast growth factor binding(GO:0017134) |
0.0 | 0.5 | GO:0042605 | peptide antigen binding(GO:0042605) |
0.0 | 0.3 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
0.0 | 0.1 | GO:0004689 | phosphorylase kinase activity(GO:0004689) |
0.0 | 0.4 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
0.0 | 0.1 | GO:0071074 | eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694) eukaryotic initiation factor eIF2 binding(GO:0071074) |
0.0 | 0.1 | GO:0008312 | 7S RNA binding(GO:0008312) |
0.0 | 0.3 | GO:0046961 | proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
0.0 | 0.2 | GO:0008409 | 5'-3' exonuclease activity(GO:0008409) |
0.0 | 1.4 | GO:0008565 | protein transporter activity(GO:0008565) |
0.0 | 1.0 | GO:0050660 | flavin adenine dinucleotide binding(GO:0050660) |
0.0 | 0.4 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
0.0 | 0.3 | GO:0030742 | GTP-dependent protein binding(GO:0030742) |
0.0 | 0.8 | GO:0016765 | transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765) |
0.0 | 0.3 | GO:0008378 | galactosyltransferase activity(GO:0008378) |
0.0 | 0.6 | GO:0017022 | myosin binding(GO:0017022) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 0.6 | PID_IL4_2PATHWAY | IL4-mediated signaling events |
0.1 | 1.0 | PID_TCR_RAS_PATHWAY | Ras signaling in the CD4+ TCR pathway |
0.1 | 3.7 | PID_FOXO_PATHWAY | FoxO family signaling |
0.0 | 0.2 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
0.0 | 0.8 | PID_AP1_PATHWAY | AP-1 transcription factor network |
0.0 | 0.4 | PID_ATF2_PATHWAY | ATF-2 transcription factor network |
0.0 | 0.4 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
0.0 | 0.9 | ST_MYOCYTE_AD_PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
0.0 | 0.5 | SA_PROGRAMMED_CELL_DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
0.0 | 1.2 | PID_SHP2_PATHWAY | SHP2 signaling |
0.0 | 1.2 | PID_ERBB4_PATHWAY | ErbB4 signaling events |
0.0 | 1.0 | PID_BMP_PATHWAY | BMP receptor signaling |
0.0 | 0.3 | PID_NEPHRIN_NEPH1_PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
0.0 | 0.5 | ST_ERK1_ERK2_MAPK_PATHWAY | ERK1/ERK2 MAPK Pathway |
0.0 | 2.5 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
0.0 | 0.6 | ST_JNK_MAPK_PATHWAY | JNK MAPK Pathway |
0.0 | 0.5 | PID_LIS1_PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
0.0 | 0.4 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
0.0 | 0.2 | PID_NECTIN_PATHWAY | Nectin adhesion pathway |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 1.6 | REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS | Genes involved in Tandem pore domain potassium channels |
0.2 | 3.4 | REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
0.2 | 0.2 | REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
0.1 | 1.1 | REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
0.1 | 3.5 | REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
0.1 | 1.3 | REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
0.1 | 2.8 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
0.1 | 3.4 | REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
0.1 | 2.1 | REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
0.1 | 1.5 | REACTOME_SYNTHESIS_OF_PC | Genes involved in Synthesis of PC |
0.0 | 0.6 | REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION | Genes involved in FGFR1 ligand binding and activation |
0.0 | 0.7 | REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
0.0 | 0.3 | REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
0.0 | 1.9 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
0.0 | 0.4 | REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
0.0 | 2.4 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
0.0 | 0.4 | REACTOME_MEMBRANE_BINDING_AND_TARGETTING_OF_GAG_PROTEINS | Genes involved in Membrane binding and targetting of GAG proteins |
0.0 | 1.1 | REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING | Genes involved in Growth hormone receptor signaling |
0.0 | 0.5 | REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE | Genes involved in NGF signalling via TRKA from the plasma membrane |
0.0 | 0.2 | REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
0.0 | 1.0 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
0.0 | 0.6 | REACTOME_ERK_MAPK_TARGETS | Genes involved in ERK/MAPK targets |
0.0 | 2.3 | REACTOME_G_ALPHA_I_SIGNALLING_EVENTS | Genes involved in G alpha (i) signalling events |
0.0 | 0.9 | REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
0.0 | 0.4 | REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
0.0 | 0.2 | REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
0.0 | 0.2 | REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
0.0 | 0.6 | REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
0.0 | 1.8 | REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
0.0 | 0.3 | REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
0.0 | 0.2 | REACTOME_FANCONI_ANEMIA_PATHWAY | Genes involved in Fanconi Anemia pathway |