Motif ID: Gmeb1

Z-value: 0.516


Transcription factors associated with Gmeb1:

Gene SymbolEntrez IDGene Name
Gmeb1 ENSMUSG00000028901.7 Gmeb1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gmeb1mm10_v2_chr4_-_132261596_1322616220.532.2e-02Click!


Activity profile for motif Gmeb1.

activity profile for motif Gmeb1


Sorted Z-values histogram for motif Gmeb1

Sorted Z-values for motif Gmeb1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gmeb1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_+_83302817 1.479 ENSMUST00000142680.1
Ap2b1
adaptor-related protein complex 2, beta 1 subunit
chr6_+_113531675 1.191 ENSMUST00000036340.5
ENSMUST00000101051.2
Fancd2

Fanconi anemia, complementation group D2

chr1_+_175880775 0.858 ENSMUST00000039725.6
Exo1
exonuclease 1
chr2_-_157007015 0.715 ENSMUST00000146413.1
Dsn1
DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)
chr17_+_23679363 0.707 ENSMUST00000024699.2
Cldn6
claudin 6
chr8_-_123949201 0.704 ENSMUST00000044795.7
Nup133
nucleoporin 133
chr19_-_40588374 0.666 ENSMUST00000175932.1
ENSMUST00000176955.1
ENSMUST00000149476.2
Aldh18a1


aldehyde dehydrogenase 18 family, member A1


chr2_-_157007039 0.663 ENSMUST00000103129.2
ENSMUST00000103130.1
Dsn1

DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)

chr19_+_43612299 0.640 ENSMUST00000057178.9
Nkx2-3
NK2 homeobox 3
chr15_+_99074968 0.575 ENSMUST00000039665.6
Troap
trophinin associated protein
chr3_-_138143352 0.566 ENSMUST00000098580.2
Mttp
microsomal triglyceride transfer protein
chr4_-_126202583 0.544 ENSMUST00000106142.1
ENSMUST00000169403.1
ENSMUST00000130334.1
Thrap3


thyroid hormone receptor associated protein 3


chr4_-_135353126 0.539 ENSMUST00000030613.4
ENSMUST00000131373.1
Srrm1

serine/arginine repetitive matrix 1

chr11_-_100822525 0.513 ENSMUST00000107358.2
Stat5b
signal transducer and activator of transcription 5B
chr11_+_83302641 0.478 ENSMUST00000176430.1
ENSMUST00000065692.7
Ap2b1

adaptor-related protein complex 2, beta 1 subunit

chr14_+_20694956 0.429 ENSMUST00000048016.1
Fut11
fucosyltransferase 11
chr17_+_84511832 0.422 ENSMUST00000047206.5
Plekhh2
pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
chr5_-_31291026 0.404 ENSMUST00000041565.7
Ift172
intraflagellar transport 172
chr18_+_36559972 0.401 ENSMUST00000134146.1
Ankhd1
ankyrin repeat and KH domain containing 1
chr5_-_93206428 0.389 ENSMUST00000144514.1
Ccni
cyclin I
chr3_+_40800013 0.378 ENSMUST00000026858.5
ENSMUST00000170825.1
Plk4

polo-like kinase 4

chr3_+_95434386 0.359 ENSMUST00000102749.4
ENSMUST00000090804.5
ENSMUST00000107161.1
ENSMUST00000107160.1
ENSMUST00000015666.10
Arnt




aryl hydrocarbon receptor nuclear translocator




chr8_-_94918012 0.355 ENSMUST00000077955.5
Ccdc102a
coiled-coil domain containing 102A
chr12_+_4917376 0.355 ENSMUST00000045664.5
Atad2b
ATPase family, AAA domain containing 2B
chr3_+_40800054 0.343 ENSMUST00000168287.1
Plk4
polo-like kinase 4
chr8_-_45333189 0.333 ENSMUST00000095328.4
Cyp4v3
cytochrome P450, family 4, subfamily v, polypeptide 3
chr10_+_80798652 0.311 ENSMUST00000151928.1
Sf3a2
splicing factor 3a, subunit 2
chrX_+_112311334 0.308 ENSMUST00000026599.3
ENSMUST00000113415.1
Apool

apolipoprotein O-like

chr15_+_81400132 0.302 ENSMUST00000163754.1
ENSMUST00000041609.4
Xpnpep3

X-prolyl aminopeptidase (aminopeptidase P) 3, putative

chr15_+_102073773 0.300 ENSMUST00000169681.1
Eif4b
eukaryotic translation initiation factor 4B
chr7_+_35397046 0.295 ENSMUST00000079414.5
Cep89
centrosomal protein 89
chr11_+_86544982 0.290 ENSMUST00000108030.2
ENSMUST00000020821.3
ENSMUST00000069503.6
ENSMUST00000167178.2
Tubd1



tubulin, delta 1



chr14_+_32085804 0.278 ENSMUST00000170600.1
ENSMUST00000168986.1
ENSMUST00000169649.1
Oxnad1


oxidoreductase NAD-binding domain containing 1


chr3_+_127553462 0.278 ENSMUST00000043108.4
4930422G04Rik
RIKEN cDNA 4930422G04 gene
chr19_-_40588453 0.278 ENSMUST00000025979.6
Aldh18a1
aldehyde dehydrogenase 18 family, member A1
chr11_-_40733373 0.273 ENSMUST00000020579.8
Hmmr
hyaluronan mediated motility receptor (RHAMM)
chr7_+_101663633 0.267 ENSMUST00000001884.7
Clpb
ClpB caseinolytic peptidase B
chr1_+_82316452 0.254 ENSMUST00000027322.7
Rhbdd1
rhomboid domain containing 1
chr7_-_141902361 0.245 ENSMUST00000055819.6
ENSMUST00000130439.1
ENSMUST00000001950.5
Tollip


toll interacting protein


chr19_-_40588338 0.240 ENSMUST00000176939.1
Aldh18a1
aldehyde dehydrogenase 18 family, member A1
chr9_-_45906837 0.227 ENSMUST00000161203.1
ENSMUST00000058720.5
ENSMUST00000160699.1
Rnf214


ring finger protein 214


chr4_+_55350043 0.226 ENSMUST00000030134.8
Rad23b
RAD23b homolog (S. cerevisiae)
chr15_-_81400043 0.222 ENSMUST00000172107.1
ENSMUST00000169204.1
ENSMUST00000163382.1
St13


suppression of tumorigenicity 13


chr6_+_29348069 0.220 ENSMUST00000173216.1
ENSMUST00000031779.10
ENSMUST00000090481.7
Calu


calumenin


chr7_+_101663705 0.204 ENSMUST00000106998.1
Clpb
ClpB caseinolytic peptidase B
chr15_-_79546741 0.201 ENSMUST00000054014.7
Ddx17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr17_-_85090204 0.195 ENSMUST00000072406.3
ENSMUST00000171795.1
Prepl

prolyl endopeptidase-like

chr10_-_112928974 0.191 ENSMUST00000099276.2
Atxn7l3b
ataxin 7-like 3B
chr11_-_6626030 0.186 ENSMUST00000000394.7
ENSMUST00000136682.1
Tbrg4

transforming growth factor beta regulated gene 4

chr4_+_128727585 0.184 ENSMUST00000106079.3
ENSMUST00000133439.1
Phc2

polyhomeotic-like 2 (Drosophila)

chr4_-_135353164 0.176 ENSMUST00000084846.5
ENSMUST00000136342.2
ENSMUST00000105861.1
Srrm1


serine/arginine repetitive matrix 1


chr7_+_5020561 0.173 ENSMUST00000085427.3
Zfp865
zinc finger protein 865
chr11_-_113751309 0.167 ENSMUST00000106616.1
Cdc42ep4
CDC42 effector protein (Rho GTPase binding) 4
chr18_-_53744509 0.151 ENSMUST00000049811.6
Cep120
centrosomal protein 120
chr15_-_81399594 0.142 ENSMUST00000023039.8
St13
suppression of tumorigenicity 13
chr3_+_138143429 0.130 ENSMUST00000040321.6
Trmt10a
tRNA methyltransferase 10A
chr11_+_50025309 0.126 ENSMUST00000054684.7
ENSMUST00000102776.4
Rnf130

ring finger protein 130

chr15_+_81872309 0.120 ENSMUST00000023116.6
Aco2
aconitase 2, mitochondrial
chr1_+_95313607 0.118 ENSMUST00000059975.6
Fam174a
family with sequence similarity 174, member A
chr9_+_108002501 0.103 ENSMUST00000035214.4
ENSMUST00000175874.1
Ip6k1

inositol hexaphosphate kinase 1

chr4_-_126202757 0.097 ENSMUST00000080919.5
Thrap3
thyroid hormone receptor associated protein 3
chr7_+_5020376 0.094 ENSMUST00000076251.4
Zfp865
zinc finger protein 865
chr5_-_93206489 0.093 ENSMUST00000058550.8
Ccni
cyclin I
chr11_-_83302586 0.087 ENSMUST00000176374.1
Pex12
peroxisomal biogenesis factor 12
chr13_-_53473074 0.087 ENSMUST00000021922.8
Msx2
msh homeobox 2
chr17_+_29549783 0.084 ENSMUST00000048677.7
Tbc1d22b
TBC1 domain family, member 22B
chr16_+_35022394 0.068 ENSMUST00000061156.8
Ptplb
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b
chr3_+_138143483 0.063 ENSMUST00000162864.1
Trmt10a
tRNA methyltransferase 10A
chr15_-_58135047 0.060 ENSMUST00000038194.3
Atad2
ATPase family, AAA domain containing 2
chr11_+_40733639 0.060 ENSMUST00000020578.4
Nudcd2
NudC domain containing 2
chr6_-_128424883 0.055 ENSMUST00000001559.8
Itfg2
integrin alpha FG-GAP repeat containing 2
chr8_-_25016901 0.053 ENSMUST00000084035.5
Adam9
a disintegrin and metallopeptidase domain 9 (meltrin gamma)
chr11_+_53770458 0.052 ENSMUST00000138913.1
ENSMUST00000123376.1
ENSMUST00000019043.6
ENSMUST00000133291.1
Irf1



interferon regulatory factor 1



chr7_-_111082997 0.048 ENSMUST00000161051.1
ENSMUST00000160132.1
ENSMUST00000106666.3
ENSMUST00000162415.1
Eif4g2



eukaryotic translation initiation factor 4, gamma 2



chr8_-_25016743 0.047 ENSMUST00000084032.5
Adam9
a disintegrin and metallopeptidase domain 9 (meltrin gamma)
chr19_+_46075842 0.047 ENSMUST00000165017.1
Nolc1
nucleolar and coiled-body phosphoprotein 1
chr16_+_20548577 0.043 ENSMUST00000003319.5
Abcf3
ATP-binding cassette, sub-family F (GCN20), member 3
chr17_+_85090647 0.038 ENSMUST00000095188.5
Camkmt
calmodulin-lysine N-methyltransferase
chr11_+_97315716 0.036 ENSMUST00000019026.3
ENSMUST00000132168.1
Mrpl45

mitochondrial ribosomal protein L45

chr1_-_91459254 0.031 ENSMUST00000069620.8
Per2
period circadian clock 2
chr10_-_81378459 0.025 ENSMUST00000140901.1
Fzr1
fizzy/cell division cycle 20 related 1 (Drosophila)
chr17_-_56626872 0.013 ENSMUST00000047226.8
Lonp1
lon peptidase 1, mitochondrial
chr19_-_41981119 0.011 ENSMUST00000026168.2
ENSMUST00000171561.1
Mms19

MMS19 (MET18 S. cerevisiae)

chr10_+_96616998 0.000 ENSMUST00000038377.7
Btg1
B cell translocation gene 1, anti-proliferative
chr19_-_44135816 0.000 ENSMUST00000026218.5
Cwf19l1
CWF19-like 1, cell cycle control (S. pombe)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0006592 ornithine biosynthetic process(GO:0006592)
0.3 1.4 GO:0051316 attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation(GO:0051316)
0.2 2.0 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.2 0.5 GO:0046544 regulation of natural killer cell proliferation(GO:0032817) positive regulation of natural killer cell proliferation(GO:0032819) development of secondary male sexual characteristics(GO:0046544)
0.2 1.2 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.1 0.6 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.1 0.6 GO:0002317 plasma cell differentiation(GO:0002317)
0.1 0.7 GO:0098535 positive regulation of centriole replication(GO:0046601) de novo centriole assembly(GO:0098535)
0.1 0.9 GO:0016446 somatic hypermutation of immunoglobulin genes(GO:0016446)
0.1 0.3 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.1 0.2 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.1 0.7 GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972)
0.0 0.4 GO:0061084 negative regulation of protein refolding(GO:0061084)
0.0 0.4 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.0 0.2 GO:0010825 positive regulation of centrosome duplication(GO:0010825)
0.0 0.1 GO:0034241 positive regulation of macrophage fusion(GO:0034241)
0.0 0.4 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.0 0.1 GO:0035880 embryonic nail plate morphogenesis(GO:0035880) positive regulation of catagen(GO:0051795) frontal suture morphogenesis(GO:0060364)
0.0 0.6 GO:0042753 positive regulation of circadian rhythm(GO:0042753)
0.0 0.4 GO:0061525 hindgut development(GO:0061525) left/right axis specification(GO:0070986)
0.0 0.3 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.0 0.3 GO:0042407 cristae formation(GO:0042407)
0.0 0.1 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.0 0.1 GO:2000564 CD8-positive, alpha-beta T cell proliferation(GO:0035740) negative regulation of regulatory T cell differentiation(GO:0045590) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564)
0.0 0.1 GO:0006102 isocitrate metabolic process(GO:0006102)
0.0 0.2 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.0 0.3 GO:0003094 glomerular filtration(GO:0003094)
0.0 0.2 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.0 0.2 GO:0036010 protein localization to endosome(GO:0036010)
0.0 0.0 GO:0031554 regulation of DNA-templated transcription, termination(GO:0031554)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:0000939 nuclear MIS12/MIND complex(GO:0000818) condensed chromosome inner kinetochore(GO:0000939)
0.1 0.7 GO:0098536 deuterosome(GO:0098536)
0.1 0.7 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 0.2 GO:0071942 XPC complex(GO:0071942)
0.0 2.0 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.3 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.3 GO:0061617 MICOS complex(GO:0061617)
0.0 0.7 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.6 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.4 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.1 GO:1990415 Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429)
0.0 0.3 GO:0097539 ciliary transition fiber(GO:0097539)
0.0 0.3 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 0.6 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.3 GO:0071004 U2 snRNP(GO:0005686) U2-type prespliceosome(GO:0071004)
0.0 0.2 GO:0035102 PRC1 complex(GO:0035102)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0017084 glutamate 5-kinase activity(GO:0004349) glutamate-5-semialdehyde dehydrogenase activity(GO:0004350) delta1-pyrroline-5-carboxylate synthetase activity(GO:0017084) amino acid kinase activity(GO:0019202)
0.2 0.9 GO:0008309 double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
0.1 0.4 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.1 0.7 GO:0001618 virus receptor activity(GO:0001618)
0.1 1.2 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 0.4 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.3 GO:0033592 RNA strand annealing activity(GO:0033592)
0.0 0.4 GO:0032564 dATP binding(GO:0032564)
0.0 0.1 GO:0051538 3 iron, 4 sulfur cluster binding(GO:0051538)
0.0 0.7 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.6 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.1 GO:0000832 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.0 2.0 GO:0030276 clathrin binding(GO:0030276)
0.0 0.2 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.0 0.6 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.0 0.2 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.2 GO:0070008 serine-type exopeptidase activity(GO:0070008)
0.0 0.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.5 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.4 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.5 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 PID_BARD1_PATHWAY BARD1 signaling events
0.0 0.5 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.4 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.1 2.0 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.5 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.0 1.2 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.6 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.3 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.7 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 0.7 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.7 REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm
0.0 0.4 REACTOME_REGULATION_OF_HYPOXIA_INDUCIBLE_FACTOR_HIF_BY_OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.0 0.3 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 0.7 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes