Motif ID: Zic3

Z-value: 0.891


Transcription factors associated with Zic3:

Gene SymbolEntrez IDGene Name
Zic3 ENSMUSG00000067860.5 Zic3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zic3mm10_v2_chrX_+_58030622_580306430.302.3e-01Click!


Activity profile for motif Zic3.

activity profile for motif Zic3


Sorted Z-values histogram for motif Zic3

Sorted Z-values for motif Zic3



Network of associatons between targets according to the STRING database.



First level regulatory network of Zic3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_-_29984219 1.505 ENSMUST00000146092.1
E2f3
E2F transcription factor 3
chr7_+_127800604 1.144 ENSMUST00000046863.5
ENSMUST00000106272.1
ENSMUST00000139068.1
Hsd3b7


hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7


chrX_+_71050160 0.991 ENSMUST00000082088.3
ENSMUST00000114629.3
Mamld1

mastermind-like domain containing 1

chr13_+_44729535 0.984 ENSMUST00000174068.1
Jarid2
jumonji, AT rich interactive domain 2
chr1_+_166254095 0.936 ENSMUST00000111416.1
Ildr2
immunoglobulin-like domain containing receptor 2
chr12_+_3806513 0.837 ENSMUST00000172719.1
Dnmt3a
DNA methyltransferase 3A
chr17_+_86963279 0.790 ENSMUST00000139344.1
Rhoq
ras homolog gene family, member Q
chr5_-_115436508 0.706 ENSMUST00000078701.3
4930430O22Rik
RIKEN cDNA 4930430O22 gene
chr5_+_139543889 0.704 ENSMUST00000174792.1
ENSMUST00000031523.8
Uncx

UNC homeobox

chr8_+_127064107 0.703 ENSMUST00000162536.1
ENSMUST00000026921.6
ENSMUST00000162665.1
ENSMUST00000160766.1
ENSMUST00000162602.1
ENSMUST00000162531.1
ENSMUST00000160581.1
ENSMUST00000161355.1
ENSMUST00000159537.1
Pard3








par-3 (partitioning defective 3) homolog (C. elegans)








chrX_+_73639414 0.694 ENSMUST00000019701.8
Dusp9
dual specificity phosphatase 9
chr7_-_49636847 0.688 ENSMUST00000032717.6
Dbx1
developing brain homeobox 1
chr13_-_95891905 0.680 ENSMUST00000068603.6
Iqgap2
IQ motif containing GTPase activating protein 2
chr8_+_4248188 0.680 ENSMUST00000110993.1
Gm14378
predicted gene 14378
chr1_-_119053339 0.674 ENSMUST00000161301.1
ENSMUST00000161451.1
ENSMUST00000162607.1
Gli2


GLI-Kruppel family member GLI2


chr8_-_18950932 0.670 ENSMUST00000055503.5
ENSMUST00000095438.3
Xkr5

X Kell blood group precursor-related family, member 5

chr7_+_73391160 0.641 ENSMUST00000128471.1
Rgma
RGM domain family, member A
chr14_+_25607797 0.637 ENSMUST00000160229.1
Zmiz1
zinc finger, MIZ-type containing 1
chrX_+_56454871 0.637 ENSMUST00000039374.2
ENSMUST00000101553.2
Ddx26b

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B

chr12_-_111813834 0.633 ENSMUST00000021715.5
Xrcc3
X-ray repair complementing defective repair in Chinese hamster cells 3
chr15_-_94404258 0.607 ENSMUST00000035342.4
ENSMUST00000155907.1
Adamts20

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 20

chr2_-_160872985 0.605 ENSMUST00000109460.1
ENSMUST00000127201.1
Zhx3

zinc fingers and homeoboxes 3

chr13_+_44730726 0.595 ENSMUST00000173704.1
ENSMUST00000044608.7
ENSMUST00000173367.1
Jarid2


jumonji, AT rich interactive domain 2


chr14_+_121035194 0.588 ENSMUST00000135010.1
Farp1
FERM, RhoGEF (Arhgef) and pleckstrin domain protein 1 (chondrocyte-derived)
chr4_+_124986430 0.569 ENSMUST00000030687.7
Rspo1
R-spondin homolog (Xenopus laevis)
chr2_+_120629113 0.541 ENSMUST00000150912.1
ENSMUST00000180041.1
Stard9

START domain containing 9

chr7_+_88278085 0.537 ENSMUST00000032779.5
ENSMUST00000128791.1
Ctsc

cathepsin C

chr11_-_100354040 0.512 ENSMUST00000173630.1
Hap1
huntingtin-associated protein 1
chr2_+_84840612 0.509 ENSMUST00000111625.1
Slc43a1
solute carrier family 43, member 1
chr5_+_107437908 0.508 ENSMUST00000094541.2
Btbd8
BTB (POZ) domain containing 8
chr9_-_56418023 0.497 ENSMUST00000061552.8
C230081A13Rik
RIKEN cDNA C230081A13 gene
chr4_+_108165449 0.496 ENSMUST00000116309.3
ENSMUST00000116307.1
Echdc2

enoyl Coenzyme A hydratase domain containing 2

chrY_-_1245753 0.488 ENSMUST00000154004.1
Uty
ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome
chr2_-_151009364 0.484 ENSMUST00000109896.1
Ninl
ninein-like
chr12_+_3807076 0.482 ENSMUST00000174817.1
Dnmt3a
DNA methyltransferase 3A
chr4_-_129614254 0.473 ENSMUST00000106037.2
ENSMUST00000179209.1
Dcdc2b

doublecortin domain containing 2b

chr11_+_115900125 0.472 ENSMUST00000142089.1
ENSMUST00000131566.1
Smim5

small integral membrane protein 5

chrY_-_1245685 0.470 ENSMUST00000143286.1
ENSMUST00000137048.1
ENSMUST00000069309.7
ENSMUST00000139365.1
Uty



ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome



chrY_-_1286563 0.458 ENSMUST00000091190.5
Ddx3y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr2_+_121295437 0.452 ENSMUST00000110639.1
Map1a
microtubule-associated protein 1 A
chr8_+_4243264 0.449 ENSMUST00000110996.1
Map2k7
mitogen-activated protein kinase kinase 7
chr11_-_34833631 0.443 ENSMUST00000093191.2
Spdl1
spindle apparatus coiled-coil protein 1
chrX_-_108834303 0.435 ENSMUST00000101283.3
ENSMUST00000150434.1
Brwd3

bromodomain and WD repeat domain containing 3

chr8_+_127064022 0.432 ENSMUST00000160272.1
ENSMUST00000079777.5
ENSMUST00000162907.1
Pard3


par-3 (partitioning defective 3) homolog (C. elegans)


chr9_-_108263887 0.425 ENSMUST00000166905.1
ENSMUST00000080435.2
Dag1

dystroglycan 1

chr7_-_48881032 0.424 ENSMUST00000058745.8
E2f8
E2F transcription factor 8
chr7_-_17062384 0.422 ENSMUST00000153833.1
ENSMUST00000108492.2
Hif3a

hypoxia inducible factor 3, alpha subunit

chr8_+_127063893 0.419 ENSMUST00000162309.1
Pard3
par-3 (partitioning defective 3) homolog (C. elegans)
chr9_-_103480328 0.416 ENSMUST00000124310.2
Bfsp2
beaded filament structural protein 2, phakinin
chr9_-_32344237 0.414 ENSMUST00000034533.5
Kcnj5
potassium inwardly-rectifying channel, subfamily J, member 5
chr3_-_108415552 0.400 ENSMUST00000090558.3
Celsr2
cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)
chr11_+_79339792 0.398 ENSMUST00000108251.2
ENSMUST00000071325.2
Nf1

neurofibromatosis 1

chr2_-_92370999 0.396 ENSMUST00000176810.1
ENSMUST00000090582.4
Gyltl1b

glycosyltransferase-like 1B

chr13_-_81633119 0.394 ENSMUST00000126444.1
ENSMUST00000128585.1
ENSMUST00000146749.1
ENSMUST00000095585.4
Gpr98



G protein-coupled receptor 98



chr7_-_109439076 0.391 ENSMUST00000106745.2
ENSMUST00000090414.4
Stk33

serine/threonine kinase 33

chr14_-_55560340 0.390 ENSMUST00000066106.3
A730061H03Rik
RIKEN cDNA A730061H03 gene
chr2_+_31640037 0.389 ENSMUST00000113470.2
Prdm12
PR domain containing 12
chr12_-_27342696 0.387 ENSMUST00000079063.5
Sox11
SRY-box containing gene 11
chr16_+_37011758 0.386 ENSMUST00000071452.5
ENSMUST00000054034.6
Polq

polymerase (DNA directed), theta

chr9_-_108263706 0.386 ENSMUST00000171412.1
Dag1
dystroglycan 1
chr17_+_84511832 0.382 ENSMUST00000047206.5
Plekhh2
pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
chr7_-_4778141 0.380 ENSMUST00000094892.5
Il11
interleukin 11
chr8_+_40423786 0.377 ENSMUST00000049389.4
ENSMUST00000128166.1
ENSMUST00000167766.1
Zdhhc2


zinc finger, DHHC domain containing 2


chr4_+_108165432 0.377 ENSMUST00000052999.6
Echdc2
enoyl Coenzyme A hydratase domain containing 2
chr6_+_17307040 0.375 ENSMUST00000123439.1
Cav1
caveolin 1, caveolae protein
chr17_-_32788284 0.371 ENSMUST00000159086.2
Zfp871
zinc finger protein 871
chr2_-_160872829 0.369 ENSMUST00000176141.1
Zhx3
zinc fingers and homeoboxes 3
chr6_-_56362356 0.367 ENSMUST00000044505.7
ENSMUST00000166102.1
ENSMUST00000164037.1
ENSMUST00000114327.2
Pde1c



phosphodiesterase 1C



chr9_-_77544829 0.367 ENSMUST00000183734.1
Lrrc1
leucine rich repeat containing 1
chr2_+_15055274 0.366 ENSMUST00000069870.3
Arl5b
ADP-ribosylation factor-like 5B
chr16_-_89960815 0.363 ENSMUST00000002588.3
Tiam1
T cell lymphoma invasion and metastasis 1
chr17_-_73710415 0.360 ENSMUST00000112591.2
ENSMUST00000024858.5
Galnt14

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14

chr2_-_170427828 0.359 ENSMUST00000013667.2
ENSMUST00000109152.2
ENSMUST00000068137.4
Bcas1


breast carcinoma amplified sequence 1


chr11_+_60537978 0.359 ENSMUST00000044250.3
Alkbh5
alkB, alkylation repair homolog 5 (E. coli)
chr11_+_97030130 0.352 ENSMUST00000153482.1
Scrn2
secernin 2
chr2_+_127008711 0.342 ENSMUST00000110394.1
ENSMUST00000002063.8
Ap4e1

adaptor-related protein complex AP-4, epsilon 1

chr19_-_4615453 0.341 ENSMUST00000053597.2
Lrfn4
leucine rich repeat and fibronectin type III domain containing 4
chrX_+_137049586 0.339 ENSMUST00000047852.7
Fam199x
family with sequence similarity 199, X-linked
chr9_+_119063429 0.337 ENSMUST00000141185.1
ENSMUST00000126251.1
ENSMUST00000136561.1
Vill


villin-like


chr14_-_54926784 0.336 ENSMUST00000022813.6
Efs
embryonal Fyn-associated substrate
chr7_-_105787544 0.335 ENSMUST00000078482.5
ENSMUST00000154659.1
Dchs1

dachsous 1 (Drosophila)

chr5_-_31291026 0.335 ENSMUST00000041565.7
Ift172
intraflagellar transport 172
chr5_-_138170992 0.333 ENSMUST00000139983.1
Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
chr10_+_80805233 0.330 ENSMUST00000036016.4
Amh
anti-Mullerian hormone
chr3_-_46447939 0.327 ENSMUST00000166505.1
Pabpc4l
poly(A) binding protein, cytoplasmic 4-like
chr9_+_85842852 0.322 ENSMUST00000098500.3
Tpbg
trophoblast glycoprotein
chr5_+_93093428 0.322 ENSMUST00000074733.7
Sept11
septin 11
chr12_-_21373606 0.320 ENSMUST00000064536.6
Adam17
a disintegrin and metallopeptidase domain 17
chr5_+_135725713 0.319 ENSMUST00000127096.1
Por
P450 (cytochrome) oxidoreductase
chr12_-_21373550 0.310 ENSMUST00000101551.3
Adam17
a disintegrin and metallopeptidase domain 17
chr2_+_131234043 0.306 ENSMUST00000041362.5
ENSMUST00000110199.2
Mavs

mitochondrial antiviral signaling protein

chr17_+_28858411 0.305 ENSMUST00000114737.1
ENSMUST00000056866.5
Pnpla1

patatin-like phospholipase domain containing 1

chr7_-_109438998 0.304 ENSMUST00000121378.1
Stk33
serine/threonine kinase 33
chr10_+_39732364 0.301 ENSMUST00000164763.1
Rev3l
REV3-like, catalytic subunit of DNA polymerase zeta RAD54 like (S. cerevisiae)
chr11_-_109473220 0.301 ENSMUST00000070872.6
Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr4_+_108460000 0.296 ENSMUST00000097925.2
Zcchc11
zinc finger, CCHC domain containing 11
chr7_+_35802593 0.296 ENSMUST00000052454.2
E130304I02Rik
RIKEN cDNA E130304I02 gene
chr6_-_39725448 0.295 ENSMUST00000002487.8
Braf
Braf transforming gene
chr2_+_29890063 0.295 ENSMUST00000028128.6
Odf2
outer dense fiber of sperm tails 2
chr1_-_152902628 0.294 ENSMUST00000111836.2
ENSMUST00000073441.6
Smg7

Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)

chr2_+_29889720 0.294 ENSMUST00000113767.1
Odf2
outer dense fiber of sperm tails 2
chr6_+_48395652 0.291 ENSMUST00000077093.4
Krba1
KRAB-A domain containing 1
chr2_-_168590315 0.289 ENSMUST00000109184.1
Nfatc2
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2
chr2_+_172550991 0.288 ENSMUST00000170744.1
Tfap2c
transcription factor AP-2, gamma
chr13_-_54687644 0.288 ENSMUST00000129881.1
Rnf44
ring finger protein 44
chr7_-_127393604 0.287 ENSMUST00000165495.1
ENSMUST00000106303.2
ENSMUST00000074249.6
E430018J23Rik


RIKEN cDNA E430018J23 gene


chr2_-_39190687 0.286 ENSMUST00000142872.1
ENSMUST00000038874.5
Scai

suppressor of cancer cell invasion

chr17_+_25951472 0.283 ENSMUST00000181174.1
D630044L22Rik
RIKEN cDNA gene D630044L22 gene
chr7_-_109438786 0.281 ENSMUST00000121748.1
Stk33
serine/threonine kinase 33
chr1_-_64121389 0.281 ENSMUST00000055001.3
Klf7
Kruppel-like factor 7 (ubiquitous)
chr2_+_156840966 0.281 ENSMUST00000109564.1
Tgif2
TGFB-induced factor homeobox 2
chr5_-_52566264 0.279 ENSMUST00000039750.5
Lgi2
leucine-rich repeat LGI family, member 2
chr2_+_27079371 0.278 ENSMUST00000091233.6
Adamtsl2
ADAMTS-like 2
chr2_+_119742306 0.277 ENSMUST00000028758.7
Itpka
inositol 1,4,5-trisphosphate 3-kinase A
chr17_+_25786566 0.275 ENSMUST00000095500.4
Ccdc78
coiled-coil domain containing 78
chr1_+_131827977 0.275 ENSMUST00000086559.6
Slc41a1
solute carrier family 41, member 1
chr9_-_82975475 0.274 ENSMUST00000034787.5
Phip
pleckstrin homology domain interacting protein
chrX_-_167382747 0.274 ENSMUST00000026839.4
Prps2
phosphoribosyl pyrophosphate synthetase 2
chr9_-_77544870 0.274 ENSMUST00000183873.1
Lrrc1
leucine rich repeat containing 1
chr7_+_51879041 0.272 ENSMUST00000107591.2
Gas2
growth arrest specific 2
chr11_-_109472611 0.272 ENSMUST00000168740.1
Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr9_+_108648720 0.272 ENSMUST00000098384.2
Gm10621
predicted gene 10621
chr10_-_49788743 0.269 ENSMUST00000105483.1
ENSMUST00000105487.1
Grik2

glutamate receptor, ionotropic, kainate 2 (beta 2)

chr2_-_92371039 0.268 ENSMUST00000068586.6
Gyltl1b
glycosyltransferase-like 1B
chr10_+_81137953 0.268 ENSMUST00000117956.1
Zbtb7a
zinc finger and BTB domain containing 7a
chr8_-_126475062 0.265 ENSMUST00000170518.1
Gm17296
predicted gene, 17296
chr17_+_34593388 0.262 ENSMUST00000174532.1
Pbx2
pre B cell leukemia homeobox 2
chr4_+_52439235 0.260 ENSMUST00000117280.1
ENSMUST00000102915.3
ENSMUST00000142227.1
Smc2


structural maintenance of chromosomes 2


chr8_-_87959560 0.259 ENSMUST00000109655.2
Zfp423
zinc finger protein 423
chr9_+_86695542 0.258 ENSMUST00000150367.2
A330041J22Rik
RIKEN cDNA A330041J22 gene
chr11_+_96789118 0.255 ENSMUST00000018810.3
Cbx1
chromobox 1
chr2_-_104816696 0.253 ENSMUST00000117237.1
Qser1
glutamine and serine rich 1
chr5_+_105732063 0.250 ENSMUST00000154807.1
Lrrc8d
leucine rich repeat containing 8D
chr13_-_24937585 0.249 ENSMUST00000037615.6
Aldh5a1
aldhehyde dehydrogenase family 5, subfamily A1
chr15_-_78544345 0.247 ENSMUST00000053239.2
Sstr3
somatostatin receptor 3
chr7_-_126799163 0.247 ENSMUST00000032934.5
Aldoa
aldolase A, fructose-bisphosphate
chrX_+_106187100 0.246 ENSMUST00000081593.6
Pgk1
phosphoglycerate kinase 1
chr14_-_31640878 0.246 ENSMUST00000167066.1
ENSMUST00000127204.2
ENSMUST00000022437.8
Hacl1


2-hydroxyacyl-CoA lyase 1


chr19_+_38481057 0.244 ENSMUST00000182481.1
Plce1
phospholipase C, epsilon 1
chr17_+_4994904 0.238 ENSMUST00000092723.4
ENSMUST00000115797.2
Arid1b

AT rich interactive domain 1B (SWI-like)

chr7_+_51878967 0.234 ENSMUST00000051912.6
Gas2
growth arrest specific 2
chr12_+_112760652 0.233 ENSMUST00000063888.3
Pld4
phospholipase D family, member 4
chr15_-_78803015 0.231 ENSMUST00000164826.1
Card10
caspase recruitment domain family, member 10
chr2_-_156111863 0.230 ENSMUST00000154889.1
ENSMUST00000079312.3
ENSMUST00000153634.1
ENSMUST00000133921.1
ENSMUST00000184265.1
ENSMUST00000109607.3
ENSMUST00000109608.2
ENSMUST00000131377.1
ENSMUST00000183518.1
Cpne1






Rbm12
RP23-220D12.12
copine I






RNA binding motif protein 12
RNA-binding protein 12
chr1_+_92831614 0.230 ENSMUST00000045970.6
Gpc1
glypican 1
chr16_-_91011029 0.230 ENSMUST00000130813.1
Synj1
synaptojanin 1
chr3_+_87930256 0.230 ENSMUST00000055984.6
Isg20l2
interferon stimulated exonuclease gene 20-like 2
chr11_+_96789213 0.230 ENSMUST00000079702.3
Cbx1
chromobox 1
chr9_-_44251464 0.227 ENSMUST00000034618.4
Pdzd3
PDZ domain containing 3
chr11_-_98149551 0.227 ENSMUST00000103143.3
Fbxl20
F-box and leucine-rich repeat protein 20
chr5_-_98030727 0.226 ENSMUST00000031281.9
Antxr2
anthrax toxin receptor 2
chr13_-_54687696 0.225 ENSMUST00000177950.1
ENSMUST00000146931.1
Rnf44

ring finger protein 44

chr11_+_50237002 0.224 ENSMUST00000180443.1
Gm26542
predicted gene, 26542
chr14_-_34374617 0.224 ENSMUST00000023826.4
Sncg
synuclein, gamma
chr5_+_105731755 0.224 ENSMUST00000127686.1
Lrrc8d
leucine rich repeat containing 8D
chr2_-_146511899 0.224 ENSMUST00000131824.1
Ralgapa2
Ral GTPase activating protein, alpha subunit 2 (catalytic)
chr9_-_106789130 0.223 ENSMUST00000046502.5
Rad54l2
RAD54 like 2 (S. cerevisiae)
chr4_+_137277489 0.223 ENSMUST00000045747.4
Wnt4
wingless-related MMTV integration site 4
chr13_+_96542727 0.223 ENSMUST00000077672.4
ENSMUST00000109444.2
Col4a3bp

collagen, type IV, alpha 3 (Goodpasture antigen) binding protein

chr4_-_62208426 0.222 ENSMUST00000068822.3
Zfp37
zinc finger protein 37
chr1_+_129273344 0.221 ENSMUST00000073527.6
ENSMUST00000040311.7
Thsd7b

thrombospondin, type I, domain containing 7B

chr7_-_19399859 0.220 ENSMUST00000047170.3
ENSMUST00000108459.2
Klc3

kinesin light chain 3

chr2_-_92370968 0.216 ENSMUST00000176774.1
Gyltl1b
glycosyltransferase-like 1B
chr6_-_124813065 0.215 ENSMUST00000149610.2
Tpi1
triosephosphate isomerase 1
chr7_+_127800844 0.214 ENSMUST00000106271.1
ENSMUST00000138432.1
Hsd3b7

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7

chr17_+_35135463 0.213 ENSMUST00000173535.1
ENSMUST00000173952.1
Bag6

BCL2-associated athanogene 6

chr12_+_3572528 0.213 ENSMUST00000173998.1
Dtnb
dystrobrevin, beta
chr11_-_70687917 0.213 ENSMUST00000108545.2
ENSMUST00000120261.1
ENSMUST00000036299.7
ENSMUST00000119120.1
ENSMUST00000100933.3
Camta2




calmodulin binding transcription activator 2




chr14_-_103843685 0.209 ENSMUST00000172237.1
Ednrb
endothelin receptor type B
chr5_-_138171248 0.208 ENSMUST00000153867.1
Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
chr1_+_187609028 0.207 ENSMUST00000110939.1
Esrrg
estrogen-related receptor gamma
chr11_+_96789149 0.206 ENSMUST00000093943.3
Cbx1
chromobox 1
chr19_+_46397009 0.204 ENSMUST00000118440.1
Sufu
suppressor of fused homolog (Drosophila)
chr3_-_100489324 0.203 ENSMUST00000061455.8
Fam46c
family with sequence similarity 46, member C
chr3_+_86224665 0.203 ENSMUST00000107635.1
Lrba
LPS-responsive beige-like anchor
chr5_-_138171216 0.203 ENSMUST00000147920.1
Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
chr1_+_59764264 0.201 ENSMUST00000087435.5
Bmpr2
bone morphogenetic protein receptor, type II (serine/threonine kinase)
chr7_+_90442729 0.201 ENSMUST00000061767.4
ENSMUST00000107206.1
Crebzf

CREB/ATF bZIP transcription factor

chr2_+_85037212 0.200 ENSMUST00000077798.6
Ssrp1
structure specific recognition protein 1
chr16_+_32673144 0.198 ENSMUST00000115122.2
ENSMUST00000115120.1
ENSMUST00000131238.1
ENSMUST00000115121.2
ENSMUST00000152361.1
Tnk2




tyrosine kinase, non-receptor, 2




chr16_+_32914094 0.198 ENSMUST00000023491.6
ENSMUST00000170899.1
ENSMUST00000171118.1
ENSMUST00000170201.1
ENSMUST00000165616.1
ENSMUST00000135193.2
Lrch3





leucine-rich repeats and calponin homology (CH) domain containing 3





chr9_+_110117703 0.197 ENSMUST00000098355.3
Gm10615
predicted gene 10615
chr16_-_30388530 0.197 ENSMUST00000100013.2
ENSMUST00000061350.6
Atp13a3

ATPase type 13A3

chr19_-_5688149 0.196 ENSMUST00000068169.5
Pcnxl3
pecanex-like 3 (Drosophila)
chr11_+_72042455 0.193 ENSMUST00000021164.3
Fam64a
family with sequence similarity 64, member A
chr5_-_110779937 0.191 ENSMUST00000112426.1
Pus1
pseudouridine synthase 1
chr10_-_63023847 0.190 ENSMUST00000119814.2
Hnrnph3
heterogeneous nuclear ribonucleoprotein H3
chr6_+_48395586 0.189 ENSMUST00000114571.1
ENSMUST00000114572.3
ENSMUST00000031815.5
Krba1


KRAB-A domain containing 1


chr1_+_191906743 0.187 ENSMUST00000044954.6
Slc30a1
solute carrier family 30 (zinc transporter), member 1
chr7_+_24370255 0.185 ENSMUST00000171904.1
Kcnn4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr2_-_20968526 0.185 ENSMUST00000141298.2
ENSMUST00000125783.2
Arhgap21

Rho GTPase activating protein 21

chrX_+_7790012 0.184 ENSMUST00000140540.1
Gripap1
GRIP1 associated protein 1
chr13_+_6548154 0.182 ENSMUST00000021611.8
Pitrm1
pitrilysin metallepetidase 1
chr2_+_156840077 0.182 ENSMUST00000081335.6
ENSMUST00000073352.3
Tgif2

TGFB-induced factor homeobox 2

chrX_+_140956892 0.181 ENSMUST00000112971.1
Atg4a
autophagy related 4A, cysteine peptidase
chr10_-_115587739 0.181 ENSMUST00000020350.8
Lgr5
leucine rich repeat containing G protein coupled receptor 5
chr2_-_119477613 0.181 ENSMUST00000110808.1
ENSMUST00000049920.7
Ino80

INO80 homolog (S. cerevisiae)

chr2_-_160872552 0.180 ENSMUST00000103111.2
Zhx3
zinc fingers and homeoboxes 3
chrX_+_52791179 0.180 ENSMUST00000101588.1
Ccdc160
coiled-coil domain containing 160
chr13_-_47105790 0.179 ENSMUST00000129352.1
Dek
DEK oncogene (DNA binding)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.6 GO:0003383 apical constriction(GO:0003383)
0.3 1.5 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.2 0.8 GO:0016340 calcium-dependent cell-matrix adhesion(GO:0016340)
0.2 1.4 GO:0035754 B cell chemotaxis(GO:0035754)
0.2 0.8 GO:0055099 response to high density lipoprotein particle(GO:0055099)
0.2 0.7 GO:0060032 notochord regression(GO:0060032)
0.2 1.3 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.2 2.0 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.1 0.4 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
0.1 0.4 GO:0060023 soft palate development(GO:0060023)
0.1 0.4 GO:1900149 positive regulation of Schwann cell migration(GO:1900149)
0.1 1.0 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.1 0.3 GO:0048162 preantral ovarian follicle growth(GO:0001546) multi-layer follicle stage(GO:0048162)
0.1 0.6 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.1 0.2 GO:0014826 vein smooth muscle contraction(GO:0014826)
0.1 0.5 GO:0032901 positive regulation of neurotrophin production(GO:0032901)
0.1 0.3 GO:0071649 regulation of chemokine (C-C motif) ligand 5 production(GO:0071649)
0.1 0.4 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.1 0.3 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.1 0.4 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.1 0.3 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
0.1 0.6 GO:0007296 vitellogenesis(GO:0007296)
0.1 0.4 GO:0035553 oxidative single-stranded RNA demethylation(GO:0035553)
0.1 0.4 GO:0033326 cerebrospinal fluid secretion(GO:0033326)
0.1 0.2 GO:1902608 regulation of large conductance calcium-activated potassium channel activity(GO:1902606) positive regulation of large conductance calcium-activated potassium channel activity(GO:1902608)
0.1 0.3 GO:0046671 negative regulation of retinal cell programmed cell death(GO:0046671)
0.1 0.7 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.1 0.3 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.1 0.2 GO:0006083 acetate metabolic process(GO:0006083)
0.1 0.4 GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914)
0.1 0.3 GO:0046210 nitrate catabolic process(GO:0043602) nitric oxide catabolic process(GO:0046210) cellular organohalogen metabolic process(GO:0090345) cellular organofluorine metabolic process(GO:0090346)
0.1 0.2 GO:0097026 dendritic cell dendrite assembly(GO:0097026)
0.1 0.2 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
0.1 0.2 GO:1904978 regulation of endosome organization(GO:1904978) positive regulation of endosome organization(GO:1904980)
0.1 0.4 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
0.1 0.4 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.1 0.7 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.1 0.3 GO:0021775 smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
0.1 0.2 GO:0060126 somatotropin secreting cell differentiation(GO:0060126) thyroid-stimulating hormone-secreting cell differentiation(GO:0060129) dermatome development(GO:0061054) regulation of dermatome development(GO:0061183) renal vesicle induction(GO:0072034) regulation of testosterone biosynthetic process(GO:2000224)
0.1 0.2 GO:0035621 ER to Golgi ceramide transport(GO:0035621) ceramide transport(GO:0035627)
0.1 0.2 GO:0019405 alditol catabolic process(GO:0019405) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.1 0.1 GO:0060022 hard palate development(GO:0060022)
0.1 0.7 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.1 0.3 GO:0046391 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.1 0.6 GO:1902913 positive regulation of melanocyte differentiation(GO:0045636) positive regulation of neuroepithelial cell differentiation(GO:1902913)
0.1 0.2 GO:0014916 regulation of lung blood pressure(GO:0014916) negative regulation of cell proliferation involved in heart morphogenesis(GO:2000137) cell proliferation involved in heart valve development(GO:2000793)
0.1 0.2 GO:0071579 regulation of zinc ion transport(GO:0071579)
0.1 0.2 GO:1901355 response to rapamycin(GO:1901355)
0.1 0.2 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.1 0.6 GO:1900121 negative regulation of receptor binding(GO:1900121)
0.1 0.1 GO:0048859 formation of anatomical boundary(GO:0048859)
0.1 0.7 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.1 0.5 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1 0.3 GO:1905244 regulation of modification of synaptic structure(GO:1905244)
0.0 0.1 GO:1901856 negative regulation of cellular respiration(GO:1901856)
0.0 0.2 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.0 0.0 GO:0007521 muscle cell fate determination(GO:0007521)
0.0 0.6 GO:2000254 regulation of male germ cell proliferation(GO:2000254)
0.0 0.7 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.2 GO:2001032 regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.0 0.2 GO:0000957 mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
0.0 0.3 GO:0098535 de novo centriole assembly(GO:0098535)
0.0 0.4 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
0.0 0.4 GO:0016446 somatic hypermutation of immunoglobulin genes(GO:0016446)
0.0 0.2 GO:0051684 maintenance of Golgi location(GO:0051684)
0.0 0.3 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 0.3 GO:2000301 myeloid progenitor cell differentiation(GO:0002318) negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0 0.1 GO:0090472 dibasic protein processing(GO:0090472)
0.0 0.2 GO:0051697 protein delipidation(GO:0051697)
0.0 0.2 GO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.0 0.1 GO:0010726 positive regulation of hydrogen peroxide metabolic process(GO:0010726)
0.0 0.1 GO:0021631 optic nerve morphogenesis(GO:0021631)
0.0 0.1 GO:0060912 cardiac cell fate specification(GO:0060912)
0.0 0.1 GO:0097402 neuroblast migration(GO:0097402)
0.0 0.3 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.0 0.2 GO:1990481 mRNA pseudouridine synthesis(GO:1990481)
0.0 0.4 GO:0034501 protein localization to kinetochore(GO:0034501)
0.0 0.3 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 0.1 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.0 0.3 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.1 GO:0070103 regulation of interleukin-6-mediated signaling pathway(GO:0070103) negative regulation of interleukin-6-mediated signaling pathway(GO:0070104)
0.0 0.8 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 0.1 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.0 0.1 GO:0038108 negative regulation of appetite by leptin-mediated signaling pathway(GO:0038108)
0.0 0.3 GO:0061525 hindgut development(GO:0061525)
0.0 0.1 GO:1902162 regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162)
0.0 0.4 GO:0070307 lens fiber cell development(GO:0070307)
0.0 0.5 GO:0038092 nodal signaling pathway(GO:0038092)
0.0 0.2 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
0.0 0.2 GO:0015838 proline transport(GO:0015824) amino-acid betaine transport(GO:0015838)
0.0 0.1 GO:0046487 glyoxylate metabolic process(GO:0046487)
0.0 0.1 GO:1902775 mitochondrial large ribosomal subunit assembly(GO:1902775)
0.0 0.1 GO:0006344 maintenance of chromatin silencing(GO:0006344)
0.0 0.1 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.0 0.5 GO:0015804 neutral amino acid transport(GO:0015804)
0.0 0.3 GO:0019433 triglyceride catabolic process(GO:0019433)
0.0 0.1 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.1 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.0 0.3 GO:0060481 lobar bronchus epithelium development(GO:0060481)
0.0 0.1 GO:0048633 positive regulation of skeletal muscle tissue growth(GO:0048633)
0.0 0.1 GO:0060050 positive regulation of protein glycosylation(GO:0060050) spindle assembly involved in meiosis(GO:0090306)
0.0 0.2 GO:0071435 potassium ion export(GO:0071435)
0.0 0.1 GO:0035519 protein K29-linked ubiquitination(GO:0035519)
0.0 0.4 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.2 GO:0006362 transcription elongation from RNA polymerase I promoter(GO:0006362)
0.0 0.5 GO:0001913 T cell mediated cytotoxicity(GO:0001913)
0.0 0.3 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.0 0.1 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)
0.0 0.2 GO:0031639 plasminogen activation(GO:0031639)
0.0 0.2 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.0 0.4 GO:1904355 positive regulation of telomere capping(GO:1904355)
0.0 0.1 GO:2001197 regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.0 0.8 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.0 0.2 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.0 0.2 GO:0071420 cellular response to histamine(GO:0071420)
0.0 0.1 GO:0036515 serotonergic neuron axon guidance(GO:0036515)
0.0 0.1 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.2 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 0.5 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.1 GO:2000465 regulation of glycogen (starch) synthase activity(GO:2000465)
0.0 0.3 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.0 GO:0046881 positive regulation of follicle-stimulating hormone secretion(GO:0046881)
0.0 0.8 GO:0030835 negative regulation of actin filament depolymerization(GO:0030835) negative regulation of protein complex disassembly(GO:0043242) negative regulation of protein depolymerization(GO:1901880)
0.0 0.2 GO:0014898 muscle hypertrophy in response to stress(GO:0003299) cardiac muscle hypertrophy in response to stress(GO:0014898)
0.0 0.1 GO:1901386 negative regulation of voltage-gated calcium channel activity(GO:1901386)
0.0 0.3 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.0 0.1 GO:0060579 ventral spinal cord interneuron fate commitment(GO:0060579) cell fate commitment involved in pattern specification(GO:0060581)
0.0 0.1 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.0 0.0 GO:0036166 phenotypic switching(GO:0036166)
0.0 0.1 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.1 GO:0009405 pathogenesis(GO:0009405)
0.0 0.1 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.0 0.1 GO:0061436 establishment of skin barrier(GO:0061436)
0.0 0.2 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.0 0.1 GO:0060178 regulation of exocyst localization(GO:0060178)
0.0 0.8 GO:0031016 pancreas development(GO:0031016)
0.0 0.1 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.1 GO:0014842 regulation of skeletal muscle satellite cell proliferation(GO:0014842) regulation of skeletal muscle cell proliferation(GO:0014857) positive regulation of myoblast proliferation(GO:2000288)
0.0 0.6 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.0 0.8 GO:0006635 fatty acid beta-oxidation(GO:0006635)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.6 GO:0033269 internode region of axon(GO:0033269)
0.1 0.8 GO:0016011 dystroglycan complex(GO:0016011)
0.1 0.6 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.1 0.7 GO:0001940 male pronucleus(GO:0001940)
0.1 0.3 GO:0098536 deuterosome(GO:0098536)
0.1 0.3 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.1 1.6 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 0.7 GO:0097542 ciliary tip(GO:0097542)
0.1 0.4 GO:0060091 kinocilium(GO:0060091)
0.1 0.3 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.7 GO:0042555 MCM complex(GO:0042555)
0.0 0.2 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.0 0.4 GO:0097165 nuclear stress granule(GO:0097165)
0.0 1.3 GO:0001741 XY body(GO:0001741)
0.0 0.3 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 0.2 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
0.0 0.6 GO:0097539 ciliary transition fiber(GO:0097539)
0.0 0.2 GO:0030132 clathrin coat of coated pit(GO:0030132)
0.0 0.3 GO:0098837 postsynaptic recycling endosome(GO:0098837)
0.0 0.5 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.4 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.1 GO:1990111 spermatoproteasome complex(GO:1990111)
0.0 0.4 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 0.4 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.2 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.3 GO:0000796 condensin complex(GO:0000796)
0.0 0.1 GO:0044305 calyx of Held(GO:0044305)
0.0 0.3 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.1 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.0 0.1 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.1 GO:0008091 spectrin(GO:0008091)
0.0 0.7 GO:0031941 filamentous actin(GO:0031941)
0.0 0.2 GO:0031011 Ino80 complex(GO:0031011)
0.0 0.5 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.1 GO:0060170 ciliary membrane(GO:0060170)
0.0 0.1 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.0 0.2 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.3 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 0.3 GO:0005811 lipid particle(GO:0005811)
0.0 0.2 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 0.1 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 0.1 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.0 GO:0043511 inhibin complex(GO:0043511)
0.0 0.1 GO:0034464 BBSome(GO:0034464)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.2 1.3 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.1 1.0 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.1 0.6 GO:0000150 recombinase activity(GO:0000150)
0.1 0.8 GO:0043237 laminin-1 binding(GO:0043237)
0.1 0.4 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.1 0.4 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.1 0.4 GO:0043515 kinetochore binding(GO:0043515)
0.1 0.5 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 0.2 GO:0004994 somatostatin receptor activity(GO:0004994)
0.1 0.3 GO:0016708 nitric oxide dioxygenase activity(GO:0008941) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor(GO:0016708) iron-cytochrome-c reductase activity(GO:0047726)
0.1 0.6 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.1 0.2 GO:0070052 collagen V binding(GO:0070052)
0.1 0.2 GO:0030249 guanylate cyclase regulator activity(GO:0030249)
0.1 0.4 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.1 0.2 GO:0004962 endothelin receptor activity(GO:0004962)
0.1 0.3 GO:0050436 microfibril binding(GO:0050436)
0.1 0.3 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.1 1.1 GO:1990226 histone methyltransferase binding(GO:1990226)
0.1 0.9 GO:0004300 enoyl-CoA hydratase activity(GO:0004300)
0.1 0.5 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
0.1 0.8 GO:0005522 profilin binding(GO:0005522)
0.1 0.7 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.1 0.2 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.1 0.3 GO:0050700 CARD domain binding(GO:0050700)
0.1 0.3 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.1 0.5 GO:0031404 chloride ion binding(GO:0031404)
0.1 0.4 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 0.4 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.1 0.3 GO:0097001 ceramide binding(GO:0097001)
0.1 0.5 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.4 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 0.6 GO:1990459 transferrin receptor binding(GO:1990459)
0.0 0.1 GO:0030226 apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.0 0.2 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.2 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.0 0.3 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.2 GO:0004966 galanin receptor activity(GO:0004966)
0.0 0.3 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.0 0.5 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.4 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.0 0.1 GO:0001565 phorbol ester receptor activity(GO:0001565) non-kinase phorbol ester receptor activity(GO:0001566)
0.0 0.6 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.2 GO:0001165 RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165)
0.0 1.3 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.5 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.1 GO:0070051 fibrinogen binding(GO:0070051)
0.0 1.6 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 1.0 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.1 GO:0097677 STAT family protein binding(GO:0097677)
0.0 0.2 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.2 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.0 0.2 GO:0098821 BMP receptor activity(GO:0098821)
0.0 0.1 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 0.2 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.0 0.2 GO:1904315 GABA-gated chloride ion channel activity(GO:0022851) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0 0.3 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.1 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.1 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.1 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.0 0.1 GO:0001069 regulatory region RNA binding(GO:0001069)
0.0 0.1 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.1 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.0 0.1 GO:2001069 glycogen binding(GO:2001069)
0.0 0.7 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 0.2 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 0.1 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.6 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.2 GO:0051400 BH domain binding(GO:0051400)
0.0 0.3 GO:0070034 telomerase RNA binding(GO:0070034)
0.0 0.4 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.0 0.6 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.1 GO:0043121 neurotrophin binding(GO:0043121)
0.0 0.6 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 0.5 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 0.3 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.1 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.0 0.4 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.2 GO:0003678 DNA helicase activity(GO:0003678)
0.0 0.2 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.2 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.3 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.1 GO:0048531 beta-1,3-galactosyltransferase activity(GO:0048531)
0.0 0.0 GO:0046624 sphingolipid transporter activity(GO:0046624)
0.0 0.1 GO:0034604 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.0 0.2 GO:0000400 four-way junction DNA binding(GO:0000400)
0.0 0.3 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.4 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 2.2 GO:0001047 core promoter binding(GO:0001047)
0.0 0.2 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.2 GO:0001054 RNA polymerase I activity(GO:0001054)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway
0.0 0.5 PID_ALK2_PATHWAY ALK2 signaling events
0.0 0.7 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 0.7 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.6 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.0 0.7 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.4 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 0.3 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.5 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.0 0.8 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.4 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.4 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 1.0 PID_PLK1_PATHWAY PLK1 signaling events
0.0 1.5 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.0 0.6 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 0.1 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.0 2.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.6 PID_ATR_PATHWAY ATR signaling pathway
0.0 0.2 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.3 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway
0.0 0.7 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.7 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.7 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 0.4 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 1.5 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.1 0.6 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1 1.6 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 1.0 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.7 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.6 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.4 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 1.0 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.4 REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 0.3 REACTOME_NFKB_ACTIVATION_THROUGH_FADD_RIP1_PATHWAY_MEDIATED_BY_CASPASE_8_AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.0 0.5 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.5 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.3 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.1 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 0.3 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.3 REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 0.2 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 0.5 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.1 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.5 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.1 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.2 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.2 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation