Motif ID: Hes5_Hes7

Z-value: 1.158

Transcription factors associated with Hes5_Hes7:

Gene SymbolEntrez IDGene Name
Hes5 ENSMUSG00000048001.7 Hes5
Hes7 ENSMUSG00000023781.2 Hes7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hes5mm10_v2_chr4_+_154960915_1549609300.781.3e-04Click!
Hes7mm10_v2_chr11_+_69120404_69120404-0.401.0e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Hes5_Hes7

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_12026237 15.721 ENSMUST00000150972.1
Grb10
growth factor receptor bound protein 10
chr11_-_12026732 14.726 ENSMUST00000143915.1
Grb10
growth factor receptor bound protein 10
chr10_-_87493651 3.606 ENSMUST00000020243.7
Ascl1
achaete-scute complex homolog 1 (Drosophila)
chr12_-_56536895 3.357 ENSMUST00000001536.8
Nkx2-1
NK2 homeobox 1
chr15_+_72913357 2.444 ENSMUST00000166418.2
Gm3150
predicted gene 3150
chr12_+_109459843 2.339 ENSMUST00000173812.1
Dlk1
delta-like 1 homolog (Drosophila)
chr13_+_51846673 2.158 ENSMUST00000021903.2
Gadd45g
growth arrest and DNA-damage-inducible 45 gamma
chr8_-_87804411 2.148 ENSMUST00000165770.2
Zfp423
zinc finger protein 423
chr4_-_132757162 2.123 ENSMUST00000030709.8
Smpdl3b
sphingomyelin phosphodiesterase, acid-like 3B
chr6_+_4755327 1.952 ENSMUST00000176551.1
Peg10
paternally expressed 10
chr4_+_137913471 1.861 ENSMUST00000151110.1
Ece1
endothelin converting enzyme 1
chr2_+_163203072 1.590 ENSMUST00000109428.2
Tox2
TOX high mobility group box family member 2
chr13_+_108316395 1.588 ENSMUST00000171178.1
Depdc1b
DEP domain containing 1B
chr1_+_72824482 1.574 ENSMUST00000047328.4
Igfbp2
insulin-like growth factor binding protein 2
chr13_+_108316332 1.485 ENSMUST00000051594.5
Depdc1b
DEP domain containing 1B
chr11_+_59306920 1.419 ENSMUST00000000128.3
ENSMUST00000108783.3
Wnt9a

wingless-type MMTV integration site 9A

chr9_+_64121501 1.362 ENSMUST00000118215.1
Lctl
lactase-like
chr10_+_79682169 1.336 ENSMUST00000020550.5
Cdc34
cell division cycle 34
chr2_+_73271925 1.319 ENSMUST00000090813.5
Sp9
trans-acting transcription factor 9
chr5_+_128601106 1.304 ENSMUST00000117102.2
Fzd10
frizzled homolog 10 (Drosophila)
chr2_-_92370999 1.287 ENSMUST00000176810.1
ENSMUST00000090582.4
Gyltl1b

glycosyltransferase-like 1B

chr15_+_39076885 1.278 ENSMUST00000067072.3
Cthrc1
collagen triple helix repeat containing 1
chr9_-_36726374 1.239 ENSMUST00000172702.2
ENSMUST00000172742.1
ENSMUST00000034625.5
Chek1


checkpoint kinase 1


chr10_+_79682304 1.124 ENSMUST00000166603.1
Cdc34
cell division cycle 34
chr8_+_119446719 0.980 ENSMUST00000098363.3
Necab2
N-terminal EF-hand calcium binding protein 2
chr2_-_92371039 0.866 ENSMUST00000068586.6
Gyltl1b
glycosyltransferase-like 1B
chr17_-_24960620 0.855 ENSMUST00000024981.7
Hn1l
hematological and neurological expressed 1-like
chr17_+_35861318 0.820 ENSMUST00000074259.8
ENSMUST00000174873.1
Nrm

nurim (nuclear envelope membrane protein)

chr11_-_59787636 0.816 ENSMUST00000125307.1
Pld6
phospholipase D family, member 6
chr3_+_104638658 0.796 ENSMUST00000046212.1
Slc16a1
solute carrier family 16 (monocarboxylic acid transporters), member 1
chr2_-_92370968 0.779 ENSMUST00000176774.1
Gyltl1b
glycosyltransferase-like 1B
chr13_+_35741313 0.725 ENSMUST00000163595.2
Cdyl
chromodomain protein, Y chromosome-like
chr11_-_50325599 0.709 ENSMUST00000179865.1
ENSMUST00000020637.8
Canx

calnexin

chr14_+_59201418 0.684 ENSMUST00000140136.2
ENSMUST00000142326.1
Rcbtb1

regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1

chr1_-_75219245 0.649 ENSMUST00000079464.6
Tuba4a
tubulin, alpha 4A
chr9_+_107587711 0.644 ENSMUST00000010192.5
Ifrd2
interferon-related developmental regulator 2
chr8_+_106603351 0.621 ENSMUST00000000312.5
ENSMUST00000167688.1
Cdh1

cadherin 1

chr3_-_95855753 0.596 ENSMUST00000161476.1
Prpf3
PRP3 pre-mRNA processing factor 3 homolog (yeast)
chr11_+_3963970 0.589 ENSMUST00000020705.4
ENSMUST00000109985.1
Pes1

pescadillo homolog 1, containing BRCT domain (zebrafish)

chr15_-_89373810 0.588 ENSMUST00000167643.2
Sco2
SCO cytochrome oxidase deficient homolog 2 (yeast)
chr1_+_131962941 0.579 ENSMUST00000177943.1
Slc45a3
solute carrier family 45, member 3
chr14_+_59201209 0.563 ENSMUST00000173547.1
ENSMUST00000043227.6
ENSMUST00000022551.7
Rcbtb1


regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1


chr3_-_101604580 0.541 ENSMUST00000036493.6
Atp1a1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr11_+_54866413 0.482 ENSMUST00000117710.1
Hint1
histidine triad nucleotide binding protein 1
chr11_+_120491840 0.471 ENSMUST00000026899.3
Slc25a10
solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10
chr11_+_97315716 0.470 ENSMUST00000019026.3
ENSMUST00000132168.1
Mrpl45

mitochondrial ribosomal protein L45

chr3_-_95855860 0.449 ENSMUST00000015892.7
Prpf3
PRP3 pre-mRNA processing factor 3 homolog (yeast)
chr6_+_91157373 0.396 ENSMUST00000155007.1
Hdac11
histone deacetylase 11
chr8_+_60632856 0.392 ENSMUST00000160719.1
Mfap3l
microfibrillar-associated protein 3-like
chr4_-_133756769 0.374 ENSMUST00000008024.6
Arid1a
AT rich interactive domain 1A (SWI-like)
chr16_-_33967032 0.353 ENSMUST00000023510.6
Umps
uridine monophosphate synthetase
chr4_-_43562397 0.333 ENSMUST00000030187.7
Tln1
talin 1
chr8_+_60632818 0.332 ENSMUST00000161421.1
Mfap3l
microfibrillar-associated protein 3-like
chr6_-_47813512 0.323 ENSMUST00000077290.7
Pdia4
protein disulfide isomerase associated 4
chr3_-_90052463 0.303 ENSMUST00000029553.9
ENSMUST00000064639.8
ENSMUST00000090908.6
Ubap2l


ubiquitin associated protein 2-like


chr7_-_65370908 0.301 ENSMUST00000032729.6
Tjp1
tight junction protein 1
chr15_+_32244801 0.301 ENSMUST00000067458.6
Sema5a
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
chr6_-_57692007 0.287 ENSMUST00000053386.5
ENSMUST00000185014.1
Pyurf
PYURF
Pigy upstream reading frame
protein preY, mitochondrial precursor
chr7_-_65371210 0.278 ENSMUST00000102592.3
Tjp1
tight junction protein 1
chr6_+_35177610 0.249 ENSMUST00000170234.1
Nup205
nucleoporin 205
chr5_+_147860615 0.242 ENSMUST00000031654.6
Pomp
proteasome maturation protein
chr11_-_78165521 0.242 ENSMUST00000017530.3
Traf4
TNF receptor associated factor 4
chr2_-_150255591 0.240 ENSMUST00000063463.5
Gm21994
predicted gene 21994
chr11_+_54866374 0.235 ENSMUST00000020504.5
Hint1
histidine triad nucleotide binding protein 1
chr11_+_4637734 0.226 ENSMUST00000109930.2
ENSMUST00000070257.7
Ascc2

activating signal cointegrator 1 complex subunit 2

chr12_+_72761211 0.219 ENSMUST00000021514.8
Ppm1a
protein phosphatase 1A, magnesium dependent, alpha isoform
chr8_-_124721956 0.206 ENSMUST00000117624.1
ENSMUST00000041614.8
ENSMUST00000118134.1
Ttc13


tetratricopeptide repeat domain 13


chr4_+_117252010 0.195 ENSMUST00000125943.1
ENSMUST00000106434.1
Tmem53

transmembrane protein 53

chr4_+_11191354 0.184 ENSMUST00000170901.1
Ccne2
cyclin E2
chr11_+_22512088 0.182 ENSMUST00000059319.7
Tmem17
transmembrane protein 17
chr18_+_11839220 0.176 ENSMUST00000171109.1
ENSMUST00000046948.8
Cables1

CDK5 and Abl enzyme substrate 1

chr17_-_25274299 0.172 ENSMUST00000172587.1
ENSMUST00000049911.9
ENSMUST00000173713.1
Ube2i


ubiquitin-conjugating enzyme E2I


chr4_+_123904832 0.169 ENSMUST00000030400.7
Mycbp
c-myc binding protein
chr7_-_99626936 0.143 ENSMUST00000178124.1
Gm4980
predicted gene 4980
chr2_+_91526756 0.139 ENSMUST00000111338.3
Ckap5
cytoskeleton associated protein 5
chr8_+_124722139 0.130 ENSMUST00000034463.3
Arv1
ARV1 homolog (yeast)
chr4_-_123904826 0.125 ENSMUST00000181292.1
Gm26606
predicted gene, 26606
chr15_-_32244632 0.119 ENSMUST00000181536.1
0610007N19Rik
RIKEN cDNA 0610007N19
chr4_+_118428078 0.107 ENSMUST00000006557.6
ENSMUST00000167636.1
ENSMUST00000102673.4
Elovl1


elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1


chr6_-_145076106 0.098 ENSMUST00000111742.1
ENSMUST00000048252.4
Bcat1

branched chain aminotransferase 1, cytosolic

chr9_+_107563246 0.097 ENSMUST00000010198.3
Tusc2
tumor suppressor candidate 2
chr11_-_86807624 0.077 ENSMUST00000018569.7
Dhx40
DEAH (Asp-Glu-Ala-His) box polypeptide 40
chr15_+_38661904 0.077 ENSMUST00000022904.6
Atp6v1c1
ATPase, H+ transporting, lysosomal V1 subunit C1
chr19_+_47178820 0.058 ENSMUST00000111808.3
Neurl1a
neuralized homolog 1A (Drosophila)
chr12_+_69372112 0.054 ENSMUST00000050063.7
Arf6
ADP-ribosylation factor 6
chr4_+_99929414 0.048 ENSMUST00000058351.9
Pgm2
phosphoglucomutase 2
chr3_+_90052814 0.047 ENSMUST00000160640.1
ENSMUST00000029552.6
ENSMUST00000162114.1
ENSMUST00000068798.6
4933434E20Rik



RIKEN cDNA 4933434E20 gene



chr9_+_20652107 0.029 ENSMUST00000034689.6
Pin1
protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1
chr1_+_63176818 0.018 ENSMUST00000129339.1
Eef1b2
eukaryotic translation elongation factor 1 beta 2
chr2_+_6322621 0.017 ENSMUST00000114937.1
Usp6nl
USP6 N-terminal like
chr10_+_36974558 0.008 ENSMUST00000105510.1
Hdac2
histone deacetylase 2
chr10_+_36974536 0.005 ENSMUST00000019911.7
Hdac2
histone deacetylase 2
chr4_+_117251951 0.001 ENSMUST00000062824.5
Tmem53
transmembrane protein 53

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.4 30.4 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
1.2 3.6 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) musculoskeletal movement, spinal reflex action(GO:0050883) olfactory pit development(GO:0060166)
1.1 3.4 GO:0021759 globus pallidus development(GO:0021759)
0.6 1.9 GO:0010814 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.3 1.0 GO:0060167 regulation of adenosine receptor signaling pathway(GO:0060167) regulation of G-protein coupled receptor internalization(GO:1904020)
0.3 2.5 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.3 2.1 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.2 2.2 GO:0042095 interferon-gamma biosynthetic process(GO:0042095)
0.2 0.6 GO:0015772 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.2 0.8 GO:0010636 positive regulation of mitochondrial fusion(GO:0010636)
0.2 1.3 GO:0038031 non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.1 1.2 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.1 0.5 GO:1903416 response to glycoside(GO:1903416)
0.1 0.6 GO:0060066 oviduct development(GO:0060066)
0.1 0.5 GO:0015744 succinate transport(GO:0015744)
0.1 0.4 GO:0009174 UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.1 1.3 GO:0033690 positive regulation of osteoblast proliferation(GO:0033690)
0.1 0.3 GO:1903334 positive regulation of protein folding(GO:1903334)
0.1 2.3 GO:0045780 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.1 1.6 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.1 1.0 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.1 0.8 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.1 0.4 GO:0006344 maintenance of chromatin silencing(GO:0006344)
0.1 0.6 GO:0007000 nucleolus organization(GO:0007000)
0.1 1.4 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.1 2.1 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 0.6 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.2 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.3 GO:0048842 positive regulation of axon extension involved in axon guidance(GO:0048842)
0.0 0.3 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 0.3 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.0 0.1 GO:0070944 neutrophil mediated killing of bacterium(GO:0070944)
0.0 2.0 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.0 0.6 GO:0008535 cellular copper ion homeostasis(GO:0006878) respiratory chain complex IV assembly(GO:0008535)
0.0 0.1 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.0 3.1 GO:0030177 positive regulation of Wnt signaling pathway(GO:0030177)
0.0 0.7 GO:0050850 positive regulation of calcium-mediated signaling(GO:0050850)
0.0 0.1 GO:0032380 regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.0 0.2 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.0 0.1 GO:1903755 regulation of SUMO transferase activity(GO:1903182) positive regulation of SUMO transferase activity(GO:1903755)
0.0 0.1 GO:0009098 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.0 0.2 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 0.2 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.7 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.0 1.3 GO:0030326 embryonic limb morphogenesis(GO:0030326) embryonic appendage morphogenesis(GO:0035113)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.9 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 0.5 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.1 0.6 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 0.7 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.1 0.2 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.1 0.6 GO:0070545 PeBoW complex(GO:0070545)
0.1 0.6 GO:0016600 flotillin complex(GO:0016600)
0.0 0.2 GO:0044611 nuclear pore inner ring(GO:0044611)
0.0 0.8 GO:0005652 nuclear lamina(GO:0005652)
0.0 1.0 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.0 0.3 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 3.6 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.4 GO:0071564 npBAF complex(GO:0071564)
0.0 0.3 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.1 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 1.3 GO:0005581 collagen trimer(GO:0005581)
0.0 0.1 GO:1990356 sumoylated E2 ligase complex(GO:1990356)
0.0 2.1 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.3 GO:0005657 replication fork(GO:0005657)
0.0 0.2 GO:0036038 MKS complex(GO:0036038)
0.0 2.9 GO:0005667 transcription factor complex(GO:0005667)
0.0 2.3 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 1.1 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.1 GO:0090543 Flemming body(GO:0090543)
0.0 0.1 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 3.4 GO:0016607 nuclear speck(GO:0016607)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 30.4 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.4 1.2 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.3 1.4 GO:0008422 beta-glucosidase activity(GO:0008422)
0.3 3.4 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.3 2.1 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.2 1.0 GO:0031687 A2A adenosine receptor binding(GO:0031687)
0.2 1.6 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.2 0.6 GO:0008515 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.2 0.5 GO:0015140 malate transmembrane transporter activity(GO:0015140)
0.1 0.8 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 0.3 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.1 2.6 GO:0017147 Wnt-protein binding(GO:0017147)
0.1 3.7 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.1 0.6 GO:0071253 connexin binding(GO:0071253)
0.1 0.5 GO:1990239 steroid hormone binding(GO:1990239)
0.1 2.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650)
0.0 0.6 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 1.4 GO:0005109 frizzled binding(GO:0005109)
0.0 0.3 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.2 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.7 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.3 GO:0015037 peptide disulfide oxidoreductase activity(GO:0015037)
0.0 0.3 GO:0031996 thioesterase binding(GO:0031996)
0.0 1.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.4 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.8 GO:0004521 endoribonuclease activity(GO:0004521)
0.0 0.1 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.0 1.2 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0 0.2 GO:0017056 structural constituent of nuclear pore(GO:0017056)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 30.4 PID_IGF1_PATHWAY IGF1 pathway
0.1 1.2 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 5.7 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 2.6 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 2.2 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.1 3.6 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 1.0 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 0.2 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.6 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 2.1 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.4 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.3 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.6 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 30.4 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.2 1.2 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 1.2 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 1.6 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 0.8 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 2.3 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 0.7 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.6 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 2.7 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.3 REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.2 REACTOME_P53_DEPENDENT_G1_DNA_DAMAGE_RESPONSE Genes involved in p53-Dependent G1 DNA Damage Response
0.0 0.5 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 3.1 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.4 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.5 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.2 REACTOME_REGULATION_OF_AMPK_ACTIVITY_VIA_LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 0.3 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions