Motif ID: E2f8

Z-value: 1.649


Transcription factors associated with E2f8:

Gene SymbolEntrez IDGene Name
E2f8 ENSMUSG00000046179.11 E2f8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f8mm10_v2_chr7_-_48881596_488816190.904.0e-07Click!


Activity profile for motif E2f8.

activity profile for motif E2f8


Sorted Z-values histogram for motif E2f8

Sorted Z-values for motif E2f8



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f8

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_24708984 5.008 ENSMUST00000154588.1
Rrm2
ribonucleotide reductase M2
chr17_+_56040350 4.894 ENSMUST00000002914.8
Chaf1a
chromatin assembly factor 1, subunit A (p150)
chr11_-_89302545 4.829 ENSMUST00000061728.3
Nog
noggin
chr17_+_56303321 4.679 ENSMUST00000001258.8
Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr8_+_75109528 4.499 ENSMUST00000164309.1
Mcm5
minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
chr6_-_94700137 4.204 ENSMUST00000101126.2
ENSMUST00000032105.4
Lrig1

leucine-rich repeats and immunoglobulin-like domains 1

chr12_+_24708241 4.093 ENSMUST00000020980.5
Rrm2
ribonucleotide reductase M2
chr1_-_128359610 3.958 ENSMUST00000027601.4
Mcm6
minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)
chr17_+_56303396 3.944 ENSMUST00000113038.1
Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr6_-_88898664 3.627 ENSMUST00000058011.6
Mcm2
minichromosome maintenance deficient 2 mitotin (S. cerevisiae)
chr10_-_21160925 3.495 ENSMUST00000020158.6
Myb
myeloblastosis oncogene
chr9_-_36726374 3.378 ENSMUST00000172702.2
ENSMUST00000172742.1
ENSMUST00000034625.5
Chek1


checkpoint kinase 1


chr11_+_98907801 3.357 ENSMUST00000092706.6
Cdc6
cell division cycle 6
chr16_-_18811615 3.351 ENSMUST00000096990.3
Cdc45
cell division cycle 45
chr7_-_115824699 3.278 ENSMUST00000169129.1
Sox6
SRY-box containing gene 6
chr5_+_123749696 3.080 ENSMUST00000031366.7
Kntc1
kinetochore associated 1
chr10_+_128015157 3.028 ENSMUST00000178041.1
ENSMUST00000026461.7
Prim1

DNA primase, p49 subunit

chr11_+_26387194 2.987 ENSMUST00000109509.1
ENSMUST00000136830.1
Fancl

Fanconi anemia, complementation group L

chr7_-_48881032 2.796 ENSMUST00000058745.8
E2f8
E2F transcription factor 8
chr2_+_163054682 2.642 ENSMUST00000018005.3
Mybl2
myeloblastosis oncogene-like 2
chr7_+_110122299 2.518 ENSMUST00000033326.8
Wee1
WEE 1 homolog 1 (S. pombe)
chr12_+_110279228 2.481 ENSMUST00000097228.4
Dio3
deiodinase, iodothyronine type III
chr6_+_117916981 2.468 ENSMUST00000179478.1
Hnrnpf
heterogeneous nuclear ribonucleoprotein F
chr6_+_117917281 2.462 ENSMUST00000180020.1
ENSMUST00000177570.1
Hnrnpf

heterogeneous nuclear ribonucleoprotein F

chr16_-_15637277 2.307 ENSMUST00000023353.3
Mcm4
minichromosome maintenance deficient 4 homolog (S. cerevisiae)
chr4_+_132768325 2.238 ENSMUST00000102561.4
Rpa2
replication protein A2
chr2_+_145785980 2.180 ENSMUST00000110005.1
ENSMUST00000094480.4
Rin2

Ras and Rab interactor 2

chr7_-_48881596 2.168 ENSMUST00000119223.1
E2f8
E2F transcription factor 8
chr5_+_111581422 2.147 ENSMUST00000064930.3
C130026L21Rik
RIKEN cDNA C130026L21 gene
chr5_-_33652296 2.080 ENSMUST00000151081.1
ENSMUST00000101354.3
Slbp

stem-loop binding protein

chr16_+_10835046 2.068 ENSMUST00000037913.8
Rmi2
RMI2, RecQ mediated genome instability 2, homolog (S. cerevisiae)
chr16_-_46496772 2.067 ENSMUST00000149901.1
ENSMUST00000096052.2
Pvrl3

poliovirus receptor-related 3

chr7_-_44548733 1.967 ENSMUST00000145956.1
ENSMUST00000049343.8
Pold1

polymerase (DNA directed), delta 1, catalytic subunit

chr19_+_38931008 1.905 ENSMUST00000145051.1
Hells
helicase, lymphoid specific
chr5_+_129020069 1.856 ENSMUST00000031383.7
ENSMUST00000111343.1
Ran

RAN, member RAS oncogene family

chr16_-_46496955 1.825 ENSMUST00000023335.6
ENSMUST00000023334.8
Pvrl3

poliovirus receptor-related 3

chr1_+_131910458 1.758 ENSMUST00000062264.6
Nucks1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr16_-_18248697 1.683 ENSMUST00000115645.3
Ranbp1
RAN binding protein 1
chr7_-_27337667 1.604 ENSMUST00000038618.6
ENSMUST00000108369.2
Ltbp4

latent transforming growth factor beta binding protein 4

chr19_+_38930909 1.569 ENSMUST00000025965.5
Hells
helicase, lymphoid specific
chr18_-_9726670 1.563 ENSMUST00000171339.1
Gm17430
predicted gene, 17430
chr13_+_94875600 1.518 ENSMUST00000022195.10
Otp
orthopedia homolog (Drosophila)
chr13_+_19623163 1.417 ENSMUST00000002883.5
Sfrp4
secreted frizzled-related protein 4
chr4_-_129189646 1.410 ENSMUST00000106059.1
S100pbp
S100P binding protein
chr2_-_157204483 1.370 ENSMUST00000029170.7
Rbl1
retinoblastoma-like 1 (p107)
chr2_-_154569845 1.359 ENSMUST00000103145.4
E2f1
E2F transcription factor 1
chr4_-_129189512 1.350 ENSMUST00000117965.1
ENSMUST00000106061.2
ENSMUST00000072431.6
S100pbp


S100P binding protein


chr4_-_129189600 1.262 ENSMUST00000117497.1
ENSMUST00000117350.1
S100pbp

S100P binding protein

chr2_-_154569720 1.225 ENSMUST00000000894.5
E2f1
E2F transcription factor 1
chr5_-_65335564 1.208 ENSMUST00000172780.1
Rfc1
replication factor C (activator 1) 1
chr5_-_65335597 1.177 ENSMUST00000172660.1
ENSMUST00000172732.1
ENSMUST00000031092.8
Rfc1


replication factor C (activator 1) 1


chr11_+_88047693 1.170 ENSMUST00000079866.4
Srsf1
serine/arginine-rich splicing factor 1
chr9_+_103305156 1.151 ENSMUST00000035164.3
Topbp1
topoisomerase (DNA) II binding protein 1
chr2_-_34913976 1.121 ENSMUST00000028232.3
Phf19
PHD finger protein 19
chr15_+_55557399 1.082 ENSMUST00000022998.7
Mtbp
Mdm2, transformed 3T3 cell double minute p53 binding protein
chrX_-_73716145 1.074 ENSMUST00000002091.5
Bcap31
B cell receptor associated protein 31
chr7_+_102065713 1.073 ENSMUST00000094129.2
ENSMUST00000094130.2
ENSMUST00000084843.3
Trpc2


transient receptor potential cation channel, subfamily C, member 2


chr6_+_35177386 1.071 ENSMUST00000043815.9
Nup205
nucleoporin 205
chr2_-_84743655 1.027 ENSMUST00000181711.1
Gm19426
predicted gene, 19426
chr5_-_33652339 0.990 ENSMUST00000075670.6
Slbp
stem-loop binding protein
chr13_+_44731265 0.990 ENSMUST00000173246.1
Jarid2
jumonji, AT rich interactive domain 2
chr6_+_35177610 0.982 ENSMUST00000170234.1
Nup205
nucleoporin 205
chr2_-_18048784 0.710 ENSMUST00000142856.1
Skida1
SKI/DACH domain containing 1
chrX_-_70477170 0.653 ENSMUST00000101506.3
ENSMUST00000114630.2
BC023829

cDNA sequence BC023829

chr9_-_50659780 0.648 ENSMUST00000034567.3
Dlat
dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)
chr11_-_21572193 0.632 ENSMUST00000102874.4
Mdh1
malate dehydrogenase 1, NAD (soluble)
chr10_+_19356558 0.565 ENSMUST00000053225.5
Olig3
oligodendrocyte transcription factor 3
chr15_+_55557575 0.471 ENSMUST00000170046.1
Mtbp
Mdm2, transformed 3T3 cell double minute p53 binding protein
chr15_-_55557748 0.470 ENSMUST00000172387.1
Mrpl13
mitochondrial ribosomal protein L13
chr3_-_127553233 0.465 ENSMUST00000029588.5
Larp7
La ribonucleoprotein domain family, member 7
chr12_+_84451485 0.369 ENSMUST00000137170.1
Lin52
lin-52 homolog (C. elegans)
chr17_+_33909481 0.365 ENSMUST00000173626.1
ENSMUST00000174541.1
Daxx

Fas death domain-associated protein

chr7_+_102065485 0.343 ENSMUST00000106950.1
ENSMUST00000146450.1
Trpc2

transient receptor potential cation channel, subfamily C, member 2

chr13_+_44731281 0.325 ENSMUST00000174086.1
Jarid2
jumonji, AT rich interactive domain 2
chr15_+_101174096 0.321 ENSMUST00000000544.9
Acvr1b
activin A receptor, type 1B
chr17_+_33909577 0.252 ENSMUST00000170075.2
Daxx
Fas death domain-associated protein
chrX_+_73716712 0.251 ENSMUST00000114461.2
Abcd1
ATP-binding cassette, sub-family D (ALD), member 1
chr7_-_128740471 0.236 ENSMUST00000119081.1
ENSMUST00000057557.7
Mcmbp

MCM (minichromosome maintenance deficient) binding protein

chr5_+_135187251 0.208 ENSMUST00000002825.5
Baz1b
bromodomain adjacent to zinc finger domain, 1B
chr9_+_22003035 0.149 ENSMUST00000115331.2
ENSMUST00000003493.7
Prkcsh

protein kinase C substrate 80K-H

chr15_+_78926720 0.145 ENSMUST00000089377.5
Lgals1
lectin, galactose binding, soluble 1
chr1_-_168431695 0.143 ENSMUST00000176790.1
Pbx1
pre B cell leukemia homeobox 1
chr11_+_88047788 0.134 ENSMUST00000107920.3
Srsf1
serine/arginine-rich splicing factor 1
chr6_+_29348069 0.121 ENSMUST00000173216.1
ENSMUST00000031779.10
ENSMUST00000090481.7
Calu


calumenin


chr3_-_90695706 0.116 ENSMUST00000069960.5
ENSMUST00000117167.1
S100a9

S100 calcium binding protein A9 (calgranulin B)

chr11_+_69991061 0.110 ENSMUST00000018711.8
Gabarap
gamma-aminobutyric acid receptor associated protein
chrX_+_73716577 0.097 ENSMUST00000002084.7
Abcd1
ATP-binding cassette, sub-family D (ALD), member 1
chr19_+_4756557 0.086 ENSMUST00000036744.7
Rbm4b
RNA binding motif protein 4B
chr11_+_88047302 0.081 ENSMUST00000139129.2
Srsf1
serine/arginine-rich splicing factor 1
chr15_+_61985377 0.074 ENSMUST00000161976.1
ENSMUST00000022971.7
Myc

myelocytomatosis oncogene

chrX_+_153498202 0.050 ENSMUST00000060714.8
Ubqln2
ubiquilin 2
chr6_-_87851011 0.045 ENSMUST00000113617.1
Cnbp
cellular nucleic acid binding protein
chr6_+_108783059 0.026 ENSMUST00000032196.6
Arl8b
ADP-ribosylation factor-like 8B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.0 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
1.4 4.2 GO:0032474 otolith morphogenesis(GO:0032474)
1.2 4.8 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
1.1 3.4 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) DNA replication preinitiation complex assembly(GO:0071163) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
1.0 9.9 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.9 2.6 GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
0.8 12.1 GO:0010216 maintenance of DNA methylation(GO:0010216)
0.8 3.0 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.7 2.0 GO:0045004 DNA replication proofreading(GO:0045004)
0.6 1.8 GO:0019046 release from viral latency(GO:0019046) regulation of DNA strand elongation(GO:0060382)
0.5 5.1 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
0.5 9.1 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.5 1.4 GO:1902174 positive regulation of keratinocyte apoptotic process(GO:1902174)
0.4 1.6 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.4 3.1 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.4 4.8 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.4 1.1 GO:1904154 protein localization to endoplasmic reticulum exit site(GO:0070973) positive regulation of retrograde protein transport, ER to cytosol(GO:1904154)
0.4 2.5 GO:0046549 phenol-containing compound catabolic process(GO:0019336) retinal cone cell development(GO:0046549)
0.3 9.0 GO:0006270 DNA replication initiation(GO:0006270)
0.3 1.6 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.3 3.3 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.3 1.4 GO:0002121 inter-male aggressive behavior(GO:0002121) response to pheromone(GO:0019236)
0.2 1.9 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.2 1.4 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.2 1.1 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.2 4.9 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.1 2.1 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.1 0.5 GO:0072737 response to diamide(GO:0072737) cellular response to diamide(GO:0072738)
0.1 0.3 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.1 0.6 GO:0097476 spinal cord motor neuron migration(GO:0097476)
0.1 1.5 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.1 0.6 GO:0006108 malate metabolic process(GO:0006108)
0.1 2.2 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.1 0.6 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.1 0.3 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
0.0 2.6 GO:0090307 mitotic spindle assembly(GO:0090307)
0.0 0.5 GO:0035562 negative regulation of chromatin binding(GO:0035562)
0.0 0.1 GO:0070488 neutrophil aggregation(GO:0070488)
0.0 1.4 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.0 2.1 GO:0033045 regulation of sister chromatid segregation(GO:0033045)
0.0 2.2 GO:0007093 mitotic cell cycle checkpoint(GO:0007093)
0.0 0.1 GO:0002317 plasma cell differentiation(GO:0002317) positive regulation of viral entry into host cell(GO:0046598)
0.0 0.0 GO:1904020 regulation of G-protein coupled receptor internalization(GO:1904020)
0.0 2.6 GO:0043484 regulation of RNA splicing(GO:0043484)
0.0 0.2 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 2.1 GO:0030010 establishment of cell polarity(GO:0030010)
0.0 0.1 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 9.1 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
1.6 4.9 GO:0033186 CAF-1 complex(GO:0033186)
1.1 3.4 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
1.0 3.1 GO:1990423 RZZ complex(GO:1990423)
1.0 14.6 GO:0042555 MCM complex(GO:0042555)
0.7 2.0 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.6 1.9 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.6 3.0 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.5 2.6 GO:0031523 Myb complex(GO:0031523)
0.5 2.6 GO:0035189 Rb-E2F complex(GO:0035189)
0.4 3.1 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.4 2.1 GO:0044611 nuclear pore inner ring(GO:0044611)
0.4 2.4 GO:0005663 DNA replication factor C complex(GO:0005663)
0.3 3.0 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.2 14.4 GO:0005657 replication fork(GO:0005657)
0.2 0.6 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.2 1.1 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.1 3.5 GO:0005721 pericentric heterochromatin(GO:0005721)
0.1 2.3 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 0.3 GO:0048179 activin receptor complex(GO:0048179)
0.1 1.2 GO:0001673 male germ cell nucleus(GO:0001673)
0.1 3.4 GO:0051233 spindle midzone(GO:0051233)
0.1 1.7 GO:1904115 axon cytoplasm(GO:1904115)
0.1 0.4 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.1 6.3 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 1.4 GO:0032590 dendrite membrane(GO:0032590)
0.0 0.5 GO:0001741 XY body(GO:0001741)
0.0 1.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 8.7 GO:0005667 transcription factor complex(GO:0005667)
0.0 3.7 GO:0016607 nuclear speck(GO:0016607)
0.0 0.3 GO:0005779 integral component of peroxisomal membrane(GO:0005779)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 8.6 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
1.8 9.1 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
1.1 3.4 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
1.0 3.1 GO:0071207 histone pre-mRNA stem-loop binding(GO:0071207)
0.9 3.5 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.8 11.5 GO:0003688 DNA replication origin binding(GO:0003688)
0.6 4.9 GO:0070087 chromo shadow domain binding(GO:0070087)
0.4 2.6 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.3 1.9 GO:0070883 pre-miRNA binding(GO:0070883)
0.2 1.4 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.2 2.0 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.2 2.4 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.2 2.2 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.2 6.3 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 4.9 GO:0017025 TBP-class protein binding(GO:0017025)
0.1 0.6 GO:0034604 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.1 1.4 GO:0019992 diacylglycerol binding(GO:0019992)
0.1 0.6 GO:0016615 malate dehydrogenase activity(GO:0016615)
0.1 2.1 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 0.3 GO:0016361 activin receptor activity, type I(GO:0016361)
0.1 6.3 GO:0019955 cytokine binding(GO:0019955)
0.1 1.1 GO:0042288 MHC class I protein binding(GO:0042288)
0.1 1.7 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.1 0.3 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.1 3.0 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.1 1.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 2.7 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 4.0 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 8.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 1.3 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.1 GO:0005534 galactose binding(GO:0005534)
0.0 1.3 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.1 GO:0050786 RAGE receptor binding(GO:0050786)
0.0 3.5 GO:0004386 helicase activity(GO:0004386)
0.0 0.5 GO:0008432 JUN kinase binding(GO:0008432)
0.0 1.8 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.6 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 2.2 GO:0001047 core promoter binding(GO:0001047)
0.0 2.0 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 3.0 GO:0061630 ubiquitin protein ligase activity(GO:0061630)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 5.9 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2 21.5 PID_E2F_PATHWAY E2F transcription factor network
0.1 5.9 PID_ATR_PATHWAY ATR signaling pathway
0.1 1.9 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 3.0 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.1 3.9 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.1 3.5 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 3.5 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.1 4.2 PID_ERBB4_PATHWAY ErbB4 signaling events
0.1 2.9 PID_BMP_PATHWAY BMP receptor signaling
0.1 2.4 PID_FAS_PATHWAY FAS (CD95) signaling pathway
0.0 2.2 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 2.3 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 0.5 PID_HIV_NEF_PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0 1.4 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.6 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 17.7 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.8 15.0 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.7 5.9 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.6 7.2 REACTOME_PROCESSIVE_SYNTHESIS_ON_THE_LAGGING_STRAND Genes involved in Processive synthesis on the lagging strand
0.3 4.4 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.3 3.1 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.2 2.5 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.2 4.8 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.1 3.0 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
0.1 3.9 REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.1 3.9 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.6 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 1.4 REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm
0.0 3.2 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.0 1.7 REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE Genes involved in Late Phase of HIV Life Cycle
0.0 4.2 REACTOME_SIGNALING_BY_EGFR_IN_CANCER Genes involved in Signaling by EGFR in Cancer
0.0 3.5 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 1.1 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.3 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.0 0.3 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.6 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.1 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling