Motif ID: Xbp1_Creb3l1
Z-value: 0.719


Transcription factors associated with Xbp1_Creb3l1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Creb3l1 | ENSMUSG00000027230.9 | Creb3l1 |
Xbp1 | ENSMUSG00000020484.12 | Xbp1 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Creb3l1 | mm10_v2_chr2_-_92024502_92024529 | -0.31 | 2.1e-01 | Click! |
Xbp1 | mm10_v2_chr11_+_5520652_5520659 | -0.22 | 3.7e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.7 | 2.2 | GO:1990523 | bone regeneration(GO:1990523) |
0.3 | 2.3 | GO:0006621 | protein retention in ER lumen(GO:0006621) |
0.2 | 0.7 | GO:0045819 | plasmacytoid dendritic cell activation(GO:0002270) positive regulation of glycogen catabolic process(GO:0045819) |
0.2 | 0.6 | GO:0031204 | posttranslational protein targeting to membrane, translocation(GO:0031204) |
0.2 | 2.0 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
0.1 | 0.4 | GO:0030200 | heparan sulfate proteoglycan catabolic process(GO:0030200) |
0.1 | 0.4 | GO:0021849 | neuroblast division in subventricular zone(GO:0021849) |
0.1 | 0.6 | GO:1901526 | negative regulation of mitochondrial membrane permeability(GO:0035795) positive regulation of macromitophagy(GO:1901526) positive regulation of mitophagy in response to mitochondrial depolarization(GO:1904925) |
0.1 | 0.3 | GO:0035359 | negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359) cell proliferation involved in heart valve development(GO:2000793) |
0.1 | 0.9 | GO:1903298 | regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903297) negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903298) |
0.1 | 0.8 | GO:1904153 | negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153) |
0.1 | 0.6 | GO:0000320 | re-entry into mitotic cell cycle(GO:0000320) |
0.1 | 0.9 | GO:0032525 | somite rostral/caudal axis specification(GO:0032525) |
0.1 | 0.7 | GO:0021937 | cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation(GO:0021937) |
0.1 | 0.7 | GO:0048251 | elastic fiber assembly(GO:0048251) |
0.1 | 0.6 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
0.1 | 1.0 | GO:0048664 | neuron fate determination(GO:0048664) |
0.1 | 0.2 | GO:0070476 | rRNA (guanine-N7)-methylation(GO:0070476) |
0.1 | 0.6 | GO:0031584 | activation of phospholipase D activity(GO:0031584) |
0.1 | 0.2 | GO:0072382 | minus-end-directed vesicle transport along microtubule(GO:0072382) |
0.1 | 0.2 | GO:0031590 | wybutosine metabolic process(GO:0031590) wybutosine biosynthetic process(GO:0031591) |
0.1 | 0.1 | GO:1903862 | positive regulation of oxidative phosphorylation(GO:1903862) |
0.1 | 0.3 | GO:2000680 | regulation of rubidium ion transport(GO:2000680) |
0.1 | 0.3 | GO:2000623 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623) |
0.1 | 0.2 | GO:0036233 | glycine import(GO:0036233) |
0.1 | 0.4 | GO:0007016 | cytoskeletal anchoring at plasma membrane(GO:0007016) |
0.1 | 0.2 | GO:0002925 | positive regulation of chronic inflammatory response(GO:0002678) positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925) |
0.0 | 0.8 | GO:0033234 | negative regulation of protein sumoylation(GO:0033234) |
0.0 | 0.3 | GO:0070561 | vitamin D receptor signaling pathway(GO:0070561) positive regulation of cell proliferation involved in heart morphogenesis(GO:2000138) |
0.0 | 0.1 | GO:0006434 | seryl-tRNA aminoacylation(GO:0006434) |
0.0 | 0.2 | GO:1901301 | regulation of cargo loading into COPII-coated vesicle(GO:1901301) |
0.0 | 0.1 | GO:0097476 | spinal cord motor neuron migration(GO:0097476) |
0.0 | 1.1 | GO:0043277 | apoptotic cell clearance(GO:0043277) |
0.0 | 0.2 | GO:0070166 | enamel mineralization(GO:0070166) |
0.0 | 0.2 | GO:0072697 | protein localization to cell cortex(GO:0072697) |
0.0 | 0.1 | GO:0060709 | glycogen cell differentiation involved in embryonic placenta development(GO:0060709) |
0.0 | 0.4 | GO:0097201 | negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201) |
0.0 | 0.1 | GO:0035519 | protein K29-linked ubiquitination(GO:0035519) |
0.0 | 0.4 | GO:0018279 | peptidyl-asparagine modification(GO:0018196) protein N-linked glycosylation via asparagine(GO:0018279) |
0.0 | 0.1 | GO:0016255 | attachment of GPI anchor to protein(GO:0016255) |
0.0 | 0.2 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
0.0 | 0.4 | GO:0005980 | polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247) |
0.0 | 0.2 | GO:0061088 | sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088) |
0.0 | 0.3 | GO:0060707 | trophoblast giant cell differentiation(GO:0060707) |
0.0 | 0.1 | GO:0072272 | proximal/distal pattern formation involved in metanephric nephron development(GO:0072272) |
0.0 | 0.6 | GO:0036075 | endochondral ossification(GO:0001958) replacement ossification(GO:0036075) |
0.0 | 0.1 | GO:2000048 | negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048) |
0.0 | 0.1 | GO:1901857 | positive regulation of cellular respiration(GO:1901857) |
0.0 | 0.8 | GO:0009311 | oligosaccharide metabolic process(GO:0009311) |
0.0 | 0.1 | GO:0090298 | mitochondrial DNA repair(GO:0043504) negative regulation of mitochondrial DNA replication(GO:0090298) |
0.0 | 0.1 | GO:2000653 | regulation of genetic imprinting(GO:2000653) |
0.0 | 0.2 | GO:0007220 | Notch receptor processing(GO:0007220) |
0.0 | 0.9 | GO:0061077 | chaperone-mediated protein folding(GO:0061077) |
0.0 | 0.6 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
0.0 | 0.1 | GO:0032596 | protein transport into membrane raft(GO:0032596) dsRNA transport(GO:0033227) |
0.0 | 0.2 | GO:0044381 | glucose import in response to insulin stimulus(GO:0044381) |
0.0 | 0.4 | GO:0043550 | regulation of lipid kinase activity(GO:0043550) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 0.8 | GO:0031205 | endoplasmic reticulum Sec complex(GO:0031205) |
0.2 | 1.5 | GO:0005786 | signal recognition particle, endoplasmic reticulum targeting(GO:0005786) |
0.1 | 1.5 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
0.1 | 2.2 | GO:0031527 | filopodium membrane(GO:0031527) |
0.1 | 0.3 | GO:0070939 | Dsl1p complex(GO:0070939) |
0.1 | 0.9 | GO:0042589 | zymogen granule membrane(GO:0042589) |
0.1 | 0.3 | GO:0097487 | multivesicular body membrane(GO:0032585) multivesicular body, internal vesicle(GO:0097487) |
0.0 | 0.3 | GO:0005785 | signal recognition particle receptor complex(GO:0005785) |
0.0 | 0.3 | GO:0005797 | Golgi medial cisterna(GO:0005797) |
0.0 | 0.1 | GO:1990730 | VCP-NSFL1C complex(GO:1990730) |
0.0 | 0.7 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
0.0 | 0.6 | GO:0065010 | extracellular membrane-bounded organelle(GO:0065010) |
0.0 | 0.1 | GO:0030905 | retromer, tubulation complex(GO:0030905) |
0.0 | 1.1 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
0.0 | 0.2 | GO:0070765 | gamma-secretase complex(GO:0070765) |
0.0 | 0.4 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
0.0 | 0.1 | GO:0042765 | GPI-anchor transamidase complex(GO:0042765) |
0.0 | 0.3 | GO:0030126 | COPI vesicle coat(GO:0030126) |
0.0 | 0.0 | GO:0016222 | procollagen-proline 4-dioxygenase complex(GO:0016222) |
0.0 | 0.1 | GO:0035032 | phosphatidylinositol 3-kinase complex, class III(GO:0035032) |
0.0 | 0.2 | GO:0002177 | manchette(GO:0002177) |
0.0 | 0.1 | GO:0097433 | dense body(GO:0097433) |
0.0 | 0.1 | GO:0072487 | MSL complex(GO:0072487) |
0.0 | 0.1 | GO:0008537 | proteasome activator complex(GO:0008537) |
0.0 | 0.2 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
0.0 | 0.2 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
0.0 | 1.1 | GO:0005811 | lipid particle(GO:0005811) |
0.0 | 0.2 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
0.0 | 0.4 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
0.0 | 0.7 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
0.0 | 0.6 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
0.0 | 0.1 | GO:0034388 | Pwp2p-containing subcomplex of 90S preribosome(GO:0034388) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 2.3 | GO:0046923 | ER retention sequence binding(GO:0046923) |
0.3 | 1.5 | GO:0030942 | endoplasmic reticulum signal peptide binding(GO:0030942) |
0.2 | 0.7 | GO:0000402 | open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402) |
0.2 | 0.8 | GO:0048408 | epidermal growth factor binding(GO:0048408) |
0.2 | 0.7 | GO:0004720 | protein-lysine 6-oxidase activity(GO:0004720) |
0.2 | 0.6 | GO:0004035 | alkaline phosphatase activity(GO:0004035) |
0.1 | 0.4 | GO:0070052 | collagen V binding(GO:0070052) |
0.1 | 0.6 | GO:0008865 | fructokinase activity(GO:0008865) mannokinase activity(GO:0019158) |
0.1 | 2.2 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
0.1 | 0.4 | GO:0008184 | glycogen phosphorylase activity(GO:0008184) |
0.1 | 0.8 | GO:0015926 | glucosidase activity(GO:0015926) |
0.1 | 1.4 | GO:0016864 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
0.1 | 0.2 | GO:0055056 | D-glucose transmembrane transporter activity(GO:0055056) |
0.1 | 0.6 | GO:0016671 | oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671) |
0.0 | 0.4 | GO:0030274 | LIM domain binding(GO:0030274) |
0.0 | 0.9 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
0.0 | 0.2 | GO:0003880 | protein C-terminal carboxyl O-methyltransferase activity(GO:0003880) |
0.0 | 0.2 | GO:0004096 | catalase activity(GO:0004096) |
0.0 | 0.4 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
0.0 | 0.1 | GO:0004828 | serine-tRNA ligase activity(GO:0004828) |
0.0 | 0.2 | GO:0004768 | stearoyl-CoA 9-desaturase activity(GO:0004768) |
0.0 | 0.1 | GO:0017099 | very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099) |
0.0 | 0.1 | GO:0036435 | deubiquitinase activator activity(GO:0035800) K48-linked polyubiquitin binding(GO:0036435) |
0.0 | 0.2 | GO:0005047 | signal recognition particle binding(GO:0005047) |
0.0 | 0.2 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
0.0 | 1.0 | GO:0071837 | HMG box domain binding(GO:0071837) |
0.0 | 0.4 | GO:0004576 | oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
0.0 | 0.8 | GO:0019789 | SUMO transferase activity(GO:0019789) |
0.0 | 0.3 | GO:0043024 | ribosomal small subunit binding(GO:0043024) |
0.0 | 0.1 | GO:1990460 | leptin receptor binding(GO:1990460) |
0.0 | 0.6 | GO:0070064 | proline-rich region binding(GO:0070064) |
0.0 | 0.1 | GO:0003923 | GPI-anchor transamidase activity(GO:0003923) |
0.0 | 0.6 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
0.0 | 11.3 | GO:0005509 | calcium ion binding(GO:0005509) |
0.0 | 0.1 | GO:1990050 | phosphatidic acid transporter activity(GO:1990050) |
0.0 | 0.8 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650) |
0.0 | 0.1 | GO:0000033 | alpha-1,3-mannosyltransferase activity(GO:0000033) |
0.0 | 0.2 | GO:0015187 | glycine transmembrane transporter activity(GO:0015187) |
0.0 | 0.0 | GO:0034046 | poly(G) binding(GO:0034046) |
0.0 | 0.3 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
0.0 | 0.0 | GO:0004656 | procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798) |
0.0 | 1.1 | GO:0019905 | syntaxin binding(GO:0019905) |
0.0 | 0.2 | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) |
0.0 | 0.1 | GO:0003910 | DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910) |
0.0 | 0.3 | GO:0008266 | poly(U) RNA binding(GO:0008266) |
0.0 | 0.3 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
0.0 | 0.0 | GO:0008312 | 7S RNA binding(GO:0008312) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 2.2 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
0.1 | 0.8 | ST_JAK_STAT_PATHWAY | Jak-STAT Pathway |
0.0 | 0.6 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
0.0 | 1.4 | PID_AMB2_NEUTROPHILS_PATHWAY | amb2 Integrin signaling |
0.0 | 0.3 | PID_IL5_PATHWAY | IL5-mediated signaling events |
0.0 | 0.4 | PID_GLYPICAN_1PATHWAY | Glypican 1 network |
0.0 | 0.3 | PID_HIF2PATHWAY | HIF-2-alpha transcription factor network |
0.0 | 0.2 | PID_SYNDECAN_3_PATHWAY | Syndecan-3-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 1.1 | REACTOME_N_GLYCAN_TRIMMING_IN_THE_ER_AND_CALNEXIN_CALRETICULIN_CYCLE | Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle |
0.1 | 4.8 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
0.0 | 0.7 | REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
0.0 | 0.9 | REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
0.0 | 0.5 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |
0.0 | 1.1 | REACTOME_LYSOSOME_VESICLE_BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
0.0 | 2.2 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
0.0 | 0.4 | REACTOME_ACTIVATION_OF_RAC | Genes involved in Activation of Rac |
0.0 | 0.6 | REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
0.0 | 0.2 | REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
0.0 | 2.5 | REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
0.0 | 0.6 | REACTOME_GLUCOSE_TRANSPORT | Genes involved in Glucose transport |
0.0 | 0.2 | REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
0.0 | 0.3 | REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
0.0 | 0.3 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
0.0 | 0.2 | REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR | Genes involved in Regulated proteolysis of p75NTR |
0.0 | 0.2 | REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |