Motif ID: Trp63

Z-value: 0.769


Transcription factors associated with Trp63:

Gene SymbolEntrez IDGene Name
Trp63 ENSMUSG00000022510.8 Trp63



Activity profile for motif Trp63.

activity profile for motif Trp63


Sorted Z-values histogram for motif Trp63

Sorted Z-values for motif Trp63



Network of associatons between targets according to the STRING database.



First level regulatory network of Trp63

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_29090969 2.379 ENSMUST00000119901.1
Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr7_-_116038734 1.587 ENSMUST00000166877.1
Sox6
SRY-box containing gene 6
chr13_-_103334429 1.531 ENSMUST00000167058.1
ENSMUST00000164111.1
Mast4

microtubule associated serine/threonine kinase family member 4

chr5_-_5265224 1.451 ENSMUST00000115450.1
Cdk14
cyclin-dependent kinase 14
chr12_-_108003414 1.265 ENSMUST00000109887.1
ENSMUST00000109891.2
Bcl11b

B cell leukemia/lymphoma 11B

chr19_+_53140430 1.176 ENSMUST00000111741.2
Add3
adducin 3 (gamma)
chr8_-_87959560 1.128 ENSMUST00000109655.2
Zfp423
zinc finger protein 423
chr14_-_122451109 1.082 ENSMUST00000081580.2
Gm5089
predicted gene 5089
chr10_-_61452658 1.041 ENSMUST00000167087.1
ENSMUST00000020288.7
Eif4ebp2

eukaryotic translation initiation factor 4E binding protein 2

chr7_-_37772868 0.989 ENSMUST00000176205.1
Zfp536
zinc finger protein 536
chr7_-_141443314 0.956 ENSMUST00000106005.2
Lrdd
leucine-rich and death domain containing
chr7_-_126160992 0.953 ENSMUST00000164741.1
Xpo6
exportin 6
chr3_-_108402589 0.952 ENSMUST00000147565.1
Celsr2
cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)
chr5_-_5266038 0.905 ENSMUST00000115451.1
ENSMUST00000115452.1
ENSMUST00000131392.1
Cdk14


cyclin-dependent kinase 14


chr11_-_106487833 0.839 ENSMUST00000106801.1
Ern1
endoplasmic reticulum (ER) to nucleus signalling 1
chr12_-_108003594 0.803 ENSMUST00000066060.4
Bcl11b
B cell leukemia/lymphoma 11B
chr2_+_59612034 0.794 ENSMUST00000112568.1
ENSMUST00000037526.4
Tanc1

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

chr2_+_109917639 0.774 ENSMUST00000046548.7
ENSMUST00000111037.2
Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr11_-_69948145 0.773 ENSMUST00000179298.1
ENSMUST00000018710.6
ENSMUST00000135437.1
ENSMUST00000141837.2
ENSMUST00000142500.1
Slc2a4




solute carrier family 2 (facilitated glucose transporter), member 4




chr5_+_142401484 0.754 ENSMUST00000072837.5
Foxk1
forkhead box K1
chr11_+_98863610 0.728 ENSMUST00000142414.1
ENSMUST00000037480.8
Wipf2

WAS/WASL interacting protein family, member 2

chr11_-_101466222 0.700 ENSMUST00000040430.7
Vat1
vesicle amine transport protein 1 homolog (T californica)
chr11_-_106487796 0.687 ENSMUST00000001059.2
ENSMUST00000106799.1
ENSMUST00000106800.1
Ern1


endoplasmic reticulum (ER) to nucleus signalling 1


chr6_+_34709610 0.597 ENSMUST00000031775.6
Cald1
caldesmon 1
chr19_-_5875210 0.554 ENSMUST00000155227.1
Frmd8
FERM domain containing 8
chr10_-_80671976 0.479 ENSMUST00000003433.6
Mknk2
MAP kinase-interacting serine/threonine kinase 2
chr19_-_5875268 0.473 ENSMUST00000025728.6
Frmd8
FERM domain containing 8
chr8_-_47352348 0.462 ENSMUST00000110367.2
Stox2
storkhead box 2
chrX_+_159255919 0.455 ENSMUST00000112492.1
Rps6ka3
ribosomal protein S6 kinase polypeptide 3
chr7_-_65370908 0.407 ENSMUST00000032729.6
Tjp1
tight junction protein 1
chr2_-_170427828 0.375 ENSMUST00000013667.2
ENSMUST00000109152.2
ENSMUST00000068137.4
Bcas1


breast carcinoma amplified sequence 1


chr2_+_119972699 0.313 ENSMUST00000066058.7
Mapkbp1
mitogen-activated protein kinase binding protein 1
chr2_-_12301914 0.290 ENSMUST00000028106.4
Itga8
integrin alpha 8
chr7_-_114254659 0.285 ENSMUST00000033012.7
Copb1
coatomer protein complex, subunit beta 1
chr15_-_8710409 0.278 ENSMUST00000157065.1
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr17_-_6449571 0.241 ENSMUST00000180035.1
Tmem181b-ps
transmembrane protein 181B, pseudogene
chr7_-_65371210 0.216 ENSMUST00000102592.3
Tjp1
tight junction protein 1
chr6_+_34709442 0.209 ENSMUST00000115021.1
Cald1
caldesmon 1
chr4_+_150855064 0.097 ENSMUST00000030811.1
Errfi1
ERBB receptor feedback inhibitor 1
chr15_+_76696725 0.074 ENSMUST00000023203.4
Gpt
glutamic pyruvic transaminase, soluble
chr4_-_134018829 0.066 ENSMUST00000051674.2
Lin28a
lin-28 homolog A (C. elegans)
chr8_+_84686300 0.022 ENSMUST00000177531.1
Trmt1
tRNA methyltransferase 1
chr13_+_12702362 0.019 ENSMUST00000104944.2
Gm2399
predicted gene 2399
chrX_+_159255782 0.008 ENSMUST00000126686.1
ENSMUST00000033671.6
Rps6ka3

ribosomal protein S6 kinase polypeptide 3

chr8_-_31918203 0.002 ENSMUST00000073884.4
Nrg1
neuregulin 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.1 GO:0021773 striatal medium spiny neuron differentiation(GO:0021773)
0.3 1.5 GO:0006987 activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.3 2.4 GO:0071493 cellular response to UV-B(GO:0071493)
0.3 0.8 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.2 1.0 GO:0033326 cerebrospinal fluid secretion(GO:0033326)
0.1 1.6 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.1 0.7 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
0.1 0.3 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.1 0.3 GO:0007256 activation of JNKK activity(GO:0007256)
0.1 1.0 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 1.0 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.1 0.6 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.5 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.0 0.1 GO:0042536 negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.0 0.8 GO:0044381 glucose import in response to insulin stimulus(GO:0044381)
0.0 0.8 GO:0097062 dendritic spine maintenance(GO:0097062)
0.0 1.1 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 2.4 GO:0000086 G2/M transition of mitotic cell cycle(GO:0000086)
0.0 0.8 GO:0006940 regulation of smooth muscle contraction(GO:0006940)
0.0 1.0 GO:0006611 protein export from nucleus(GO:0006611)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0070557 PCNA-p21 complex(GO:0070557)
0.5 2.4 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.3 1.5 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.1 0.8 GO:0030478 actin cap(GO:0030478)
0.1 0.6 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.8 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.3 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.3 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.3 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 1.2 GO:0000794 condensed nuclear chromosome(GO:0000794)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.2 0.8 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.1 1.0 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.1 1.5 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.1 0.6 GO:0071253 connexin binding(GO:0071253)
0.1 1.0 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 0.8 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 2.4 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 0.3 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.5 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 1.0 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 1.2 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.5 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.4 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.8 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.9 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.6 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.3 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 2.4 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.1 0.8 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.3 REACTOME_COPI_MEDIATED_TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.8 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 1.5 REACTOME_UNFOLDED_PROTEIN_RESPONSE Genes involved in Unfolded Protein Response
0.0 0.5 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets