Motif ID: Hsf1
Z-value: 0.629

Transcription factors associated with Hsf1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Hsf1 | ENSMUSG00000022556.9 | Hsf1 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Hsf1 | mm10_v2_chr15_+_76477404_76477461 | -0.50 | 3.3e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.8 | 3.0 | GO:0046552 | eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552) |
0.5 | 1.8 | GO:0002924 | negative regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002924) negative regulation of interleukin-6 biosynthetic process(GO:0045409) |
0.4 | 1.7 | GO:0045343 | MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343) positive regulation of MHC class I biosynthetic process(GO:0045345) positive regulation of NK T cell activation(GO:0051135) |
0.3 | 1.0 | GO:1903054 | protein targeting to vacuole involved in autophagy(GO:0071211) lysosomal membrane organization(GO:0097212) negative regulation of extracellular matrix organization(GO:1903054) positive regulation of protein folding(GO:1903334) |
0.3 | 3.2 | GO:1990173 | protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) protein localization to nucleoplasm(GO:1990173) |
0.3 | 1.6 | GO:0045583 | regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585) |
0.3 | 1.3 | GO:0060849 | regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849) |
0.2 | 0.8 | GO:1902268 | negative regulation of polyamine transmembrane transport(GO:1902268) |
0.2 | 1.4 | GO:0003433 | chondrocyte development involved in endochondral bone morphogenesis(GO:0003433) |
0.2 | 0.5 | GO:0070315 | G1 to G0 transition involved in cell differentiation(GO:0070315) |
0.2 | 0.7 | GO:0007412 | axon target recognition(GO:0007412) |
0.1 | 0.6 | GO:0030576 | Cajal body organization(GO:0030576) |
0.1 | 0.8 | GO:0043654 | recognition of apoptotic cell(GO:0043654) |
0.1 | 0.4 | GO:0071492 | cellular response to UV-A(GO:0071492) |
0.1 | 1.0 | GO:0042769 | DNA damage response, detection of DNA damage(GO:0042769) |
0.1 | 0.3 | GO:0070682 | proteasome regulatory particle assembly(GO:0070682) |
0.1 | 0.3 | GO:0046022 | regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022) |
0.1 | 1.4 | GO:0070307 | lens fiber cell development(GO:0070307) |
0.1 | 0.7 | GO:0044806 | G-quadruplex DNA unwinding(GO:0044806) |
0.1 | 0.3 | GO:2000501 | natural killer cell chemotaxis(GO:0035747) regulation of natural killer cell chemotaxis(GO:2000501) |
0.1 | 0.3 | GO:0035771 | interleukin-4-mediated signaling pathway(GO:0035771) |
0.1 | 0.5 | GO:0034421 | post-translational protein acetylation(GO:0034421) |
0.1 | 0.9 | GO:0032876 | negative regulation of DNA endoreduplication(GO:0032876) |
0.1 | 0.3 | GO:0002842 | positive regulation of T cell mediated immune response to tumor cell(GO:0002842) protein import into mitochondrial intermembrane space(GO:0045041) |
0.1 | 0.5 | GO:0042535 | positive regulation of tumor necrosis factor biosynthetic process(GO:0042535) |
0.1 | 0.5 | GO:0045650 | negative regulation of macrophage differentiation(GO:0045650) |
0.1 | 0.3 | GO:0060032 | notochord regression(GO:0060032) |
0.1 | 0.5 | GO:0000056 | ribosomal small subunit export from nucleus(GO:0000056) |
0.1 | 0.3 | GO:0006564 | L-serine biosynthetic process(GO:0006564) |
0.1 | 1.3 | GO:0031115 | negative regulation of microtubule polymerization(GO:0031115) |
0.1 | 0.4 | GO:1901164 | negative regulation of trophoblast cell migration(GO:1901164) |
0.1 | 0.7 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
0.1 | 0.7 | GO:0034244 | negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244) |
0.1 | 0.4 | GO:0061084 | negative regulation of protein refolding(GO:0061084) |
0.0 | 0.5 | GO:0071318 | cellular response to ATP(GO:0071318) |
0.0 | 0.2 | GO:0002457 | T cell antigen processing and presentation(GO:0002457) |
0.0 | 0.5 | GO:0060837 | blood vessel endothelial cell differentiation(GO:0060837) |
0.0 | 0.5 | GO:0014807 | regulation of somitogenesis(GO:0014807) |
0.0 | 0.4 | GO:0006027 | glycosaminoglycan catabolic process(GO:0006027) |
0.0 | 0.7 | GO:0030213 | hyaluronan biosynthetic process(GO:0030213) |
0.0 | 0.1 | GO:0009838 | abscission(GO:0009838) |
0.0 | 0.8 | GO:0070286 | axonemal dynein complex assembly(GO:0070286) |
0.0 | 0.5 | GO:0051085 | chaperone mediated protein folding requiring cofactor(GO:0051085) |
0.0 | 0.7 | GO:0045116 | protein neddylation(GO:0045116) |
0.0 | 0.3 | GO:0030259 | lipid glycosylation(GO:0030259) |
0.0 | 1.4 | GO:0061077 | chaperone-mediated protein folding(GO:0061077) |
0.0 | 0.5 | GO:0021796 | cerebral cortex regionalization(GO:0021796) embryonic brain development(GO:1990403) |
0.0 | 0.3 | GO:0090037 | positive regulation of protein kinase C signaling(GO:0090037) |
0.0 | 0.3 | GO:0030238 | male sex determination(GO:0030238) |
0.0 | 0.2 | GO:0061299 | retina vasculature morphogenesis in camera-type eye(GO:0061299) |
0.0 | 1.5 | GO:0032024 | positive regulation of insulin secretion(GO:0032024) |
0.0 | 0.6 | GO:0046470 | phosphatidylcholine metabolic process(GO:0046470) |
0.0 | 0.1 | GO:1900533 | medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535) |
0.0 | 0.2 | GO:0030948 | negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 1.6 | GO:0097226 | sperm mitochondrial sheath(GO:0097226) |
0.3 | 3.2 | GO:0005832 | chaperonin-containing T-complex(GO:0005832) |
0.2 | 1.0 | GO:0043202 | lysosomal lumen(GO:0043202) |
0.2 | 0.5 | GO:0031074 | nucleocytoplasmic shuttling complex(GO:0031074) |
0.1 | 0.7 | GO:0071598 | neuronal ribonucleoprotein granule(GO:0071598) |
0.1 | 0.7 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
0.0 | 0.3 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
0.0 | 0.5 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
0.0 | 0.2 | GO:0097512 | cardiac myofibril(GO:0097512) |
0.0 | 0.3 | GO:0008540 | proteasome regulatory particle, base subcomplex(GO:0008540) |
0.0 | 1.3 | GO:0044295 | axonal growth cone(GO:0044295) |
0.0 | 1.5 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
0.0 | 1.4 | GO:0005882 | intermediate filament(GO:0005882) |
0.0 | 0.3 | GO:0097542 | ciliary tip(GO:0097542) |
0.0 | 0.2 | GO:0042612 | MHC class I protein complex(GO:0042612) |
0.0 | 0.6 | GO:0015030 | Cajal body(GO:0015030) |
0.0 | 0.7 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
0.0 | 0.5 | GO:0005637 | nuclear inner membrane(GO:0005637) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 1.0 | GO:0031686 | A1 adenosine receptor binding(GO:0031686) |
0.3 | 1.3 | GO:0032767 | copper-dependent protein binding(GO:0032767) |
0.2 | 1.4 | GO:0002135 | CTP binding(GO:0002135) |
0.2 | 0.8 | GO:0008073 | ornithine decarboxylase inhibitor activity(GO:0008073) |
0.2 | 0.6 | GO:0070140 | isopeptidase activity(GO:0070122) ubiquitin-like protein-specific isopeptidase activity(GO:0070138) SUMO-specific isopeptidase activity(GO:0070140) |
0.2 | 1.7 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
0.2 | 0.8 | GO:0070815 | peptidyl-lysine 5-dioxygenase activity(GO:0070815) |
0.2 | 0.7 | GO:0031694 | alpha-2A adrenergic receptor binding(GO:0031694) |
0.1 | 1.0 | GO:0055131 | C3HC4-type RING finger domain binding(GO:0055131) |
0.1 | 0.4 | GO:0052740 | phosphatidylserine 1-acylhydrolase activity(GO:0052739) 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740) |
0.1 | 0.4 | GO:0032564 | dATP binding(GO:0032564) |
0.1 | 1.1 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
0.1 | 4.0 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
0.1 | 0.7 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
0.1 | 0.3 | GO:0004647 | phosphoserine phosphatase activity(GO:0004647) |
0.1 | 1.3 | GO:0001972 | retinoic acid binding(GO:0001972) |
0.1 | 0.5 | GO:0070883 | pre-miRNA binding(GO:0070883) |
0.1 | 0.7 | GO:0019788 | NEDD8 transferase activity(GO:0019788) |
0.1 | 0.3 | GO:0045131 | pre-mRNA branch point binding(GO:0045131) |
0.1 | 0.5 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
0.1 | 0.5 | GO:0046790 | virion binding(GO:0046790) |
0.1 | 0.5 | GO:0031432 | titin binding(GO:0031432) |
0.1 | 0.4 | GO:0016018 | cyclosporin A binding(GO:0016018) |
0.1 | 0.4 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
0.0 | 0.3 | GO:0005021 | vascular endothelial growth factor-activated receptor activity(GO:0005021) |
0.0 | 0.7 | GO:0004862 | cAMP-dependent protein kinase inhibitor activity(GO:0004862) |
0.0 | 2.2 | GO:0051082 | unfolded protein binding(GO:0051082) |
0.0 | 0.2 | GO:0004142 | diacylglycerol cholinephosphotransferase activity(GO:0004142) |
0.0 | 0.3 | GO:0031730 | CCR5 chemokine receptor binding(GO:0031730) |
0.0 | 1.4 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
0.0 | 1.0 | GO:0030544 | Hsp70 protein binding(GO:0030544) |
0.0 | 0.1 | GO:0008502 | melatonin receptor activity(GO:0008502) |
0.0 | 0.4 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
0.0 | 3.0 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
0.0 | 0.3 | GO:1990226 | histone methyltransferase binding(GO:1990226) |
0.0 | 0.2 | GO:0030881 | beta-2-microglobulin binding(GO:0030881) |
0.0 | 0.5 | GO:0070717 | poly-purine tract binding(GO:0070717) |
0.0 | 0.7 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
0.0 | 0.1 | GO:0016300 | tRNA (uracil) methyltransferase activity(GO:0016300) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 1.6 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
0.0 | 1.4 | PID_AURORA_A_PATHWAY | Aurora A signaling |
0.0 | 0.3 | PID_VEGF_VEGFR_PATHWAY | VEGF and VEGFR signaling network |
0.0 | 1.3 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
0.0 | 1.4 | PID_PLK1_PATHWAY | PLK1 signaling events |
0.0 | 2.0 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
0.0 | 0.5 | ST_P38_MAPK_PATHWAY | p38 MAPK Pathway |
0.0 | 1.0 | PID_AR_TF_PATHWAY | Regulation of Androgen receptor activity |
0.0 | 0.7 | PID_ALPHA_SYNUCLEIN_PATHWAY | Alpha-synuclein signaling |
0.0 | 1.3 | PID_CMYB_PATHWAY | C-MYB transcription factor network |
0.0 | 0.5 | PID_P38_MKK3_6PATHWAY | p38 MAPK signaling pathway |
0.0 | 0.6 | PID_IL12_2PATHWAY | IL12-mediated signaling events |
0.0 | 0.5 | PID_IL6_7_PATHWAY | IL6-mediated signaling events |
0.0 | 0.3 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 3.2 | REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
0.1 | 0.5 | REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
0.1 | 1.6 | REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
0.1 | 0.5 | REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR | Genes involved in Trafficking and processing of endosomal TLR |
0.0 | 0.4 | REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
0.0 | 1.0 | REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
0.0 | 0.5 | REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
0.0 | 0.3 | REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
0.0 | 0.5 | REACTOME_MICRORNA_MIRNA_BIOGENESIS | Genes involved in MicroRNA (miRNA) Biogenesis |
0.0 | 1.4 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
0.0 | 2.0 | REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
0.0 | 1.2 | REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
0.0 | 0.2 | REACTOME_SYNTHESIS_OF_PE | Genes involved in Synthesis of PE |
0.0 | 1.4 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
0.0 | 0.3 | REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
0.0 | 0.3 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |