Motif ID: E2f7

Z-value: 1.707


Transcription factors associated with E2f7:

Gene SymbolEntrez IDGene Name
E2f7 ENSMUSG00000020185.10 E2f7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f7mm10_v2_chr10_+_110745433_1107455720.484.3e-02Click!


Activity profile for motif E2f7.

activity profile for motif E2f7


Sorted Z-values histogram for motif E2f7

Sorted Z-values for motif E2f7



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f7

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_3037111 11.392 ENSMUST00000177969.1
Gm10715
predicted gene 10715
chr9_+_3013140 11.331 ENSMUST00000143083.2
Gm10721
predicted gene 10721
chr9_+_3025417 10.210 ENSMUST00000075573.6
Gm10717
predicted gene 10717
chr9_+_3015654 8.540 ENSMUST00000099050.3
Gm10720
predicted gene 10720
chr9_+_3017408 8.150 ENSMUST00000099049.3
Gm10719
predicted gene 10719
chr7_-_116308241 7.105 ENSMUST00000183057.1
ENSMUST00000182487.1
ENSMUST00000181998.1
Plekha7


pleckstrin homology domain containing, family A member 7


chr4_+_108579445 4.378 ENSMUST00000102744.3
Orc1
origin recognition complex, subunit 1
chr12_+_24708984 4.210 ENSMUST00000154588.1
Rrm2
ribonucleotide reductase M2
chr13_-_100775844 3.854 ENSMUST00000075550.3
Cenph
centromere protein H
chr12_+_24708241 3.557 ENSMUST00000020980.5
Rrm2
ribonucleotide reductase M2
chr6_-_67037399 3.493 ENSMUST00000043098.6
Gadd45a
growth arrest and DNA-damage-inducible 45 alpha
chr10_-_69352886 3.487 ENSMUST00000119827.1
ENSMUST00000020099.5
Cdk1

cyclin-dependent kinase 1

chr13_-_21783391 3.444 ENSMUST00000099704.3
Hist1h3i
histone cluster 1, H3i
chr11_+_102248842 3.123 ENSMUST00000100392.4
BC030867
cDNA sequence BC030867
chr13_+_23581563 2.919 ENSMUST00000102968.1
Hist1h4d
histone cluster 1, H4d
chr11_-_77513335 2.898 ENSMUST00000060417.4
Trp53i13
transformation related protein 53 inducible protein 13
chr10_+_3973086 2.799 ENSMUST00000117291.1
ENSMUST00000120585.1
ENSMUST00000043735.7
Mthfd1l


methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like


chr14_-_20388822 2.751 ENSMUST00000022345.6
Dnajc9
DnaJ (Hsp40) homolog, subfamily C, member 9
chr11_-_6444352 2.639 ENSMUST00000093346.5
ENSMUST00000109737.2
H2afv

H2A histone family, member V

chr8_+_75109528 2.616 ENSMUST00000164309.1
Mcm5
minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
chr3_+_108383829 2.554 ENSMUST00000090561.3
ENSMUST00000102629.1
ENSMUST00000128089.1
Psrc1


proline/serine-rich coiled-coil 1


chr15_+_79030874 2.478 ENSMUST00000171999.1
ENSMUST00000006544.7
Gcat

glycine C-acetyltransferase (2-amino-3-ketobutyrate-coenzyme A ligase)

chr19_-_41206774 2.476 ENSMUST00000025986.7
ENSMUST00000169941.1
Tll2

tolloid-like 2

chr2_+_112261926 2.470 ENSMUST00000028553.3
Nop10
NOP10 ribonucleoprotein
chr4_+_132768325 2.451 ENSMUST00000102561.4
Rpa2
replication protein A2
chr15_+_102296256 2.380 ENSMUST00000064924.4
Espl1
extra spindle poles-like 1 (S. cerevisiae)
chr13_-_21833575 2.317 ENSMUST00000081342.5
Hist1h2ap
histone cluster 1, H2ap
chr5_+_129020069 2.307 ENSMUST00000031383.7
ENSMUST00000111343.1
Ran

RAN, member RAS oncogene family

chr4_+_136172367 2.134 ENSMUST00000061721.5
E2f2
E2F transcription factor 2
chr17_-_35516780 2.114 ENSMUST00000160885.1
ENSMUST00000159009.1
ENSMUST00000161012.1
Tcf19


transcription factor 19


chr13_+_22043189 2.059 ENSMUST00000110452.1
Hist1h2bj
histone cluster 1, H2bj
chr1_+_86526688 1.991 ENSMUST00000045897.8
Ptma
prothymosin alpha
chr1_-_128359610 1.939 ENSMUST00000027601.4
Mcm6
minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)
chr13_+_21833736 1.902 ENSMUST00000180288.1
ENSMUST00000110467.1
Hist1h2br

histone cluster 1 H2br

chr2_-_157204483 1.893 ENSMUST00000029170.7
Rbl1
retinoblastoma-like 1 (p107)
chr9_+_64281575 1.881 ENSMUST00000034964.6
Tipin
timeless interacting protein
chr5_+_9100681 1.879 ENSMUST00000115365.1
Tmem243
transmembrane protein 243, mitochondrial
chr17_-_24960620 1.876 ENSMUST00000024981.7
Hn1l
hematological and neurological expressed 1-like
chr11_-_101466222 1.857 ENSMUST00000040430.7
Vat1
vesicle amine transport protein 1 homolog (T californica)
chr13_-_22042949 1.816 ENSMUST00000091741.4
Hist1h2ag
histone cluster 1, H2ag
chr13_+_21754067 1.767 ENSMUST00000091709.2
Hist1h2bn
histone cluster 1, H2bn
chr6_-_88898664 1.759 ENSMUST00000058011.6
Mcm2
minichromosome maintenance deficient 2 mitotin (S. cerevisiae)
chr13_+_21810428 1.748 ENSMUST00000091745.5
Hist1h2ao
histone cluster 1, H2ao
chr13_-_21716143 1.703 ENSMUST00000091756.1
Hist1h2bl
histone cluster 1, H2bl
chrX_+_162760388 1.668 ENSMUST00000033720.5
ENSMUST00000112327.1
Rbbp7

retinoblastoma binding protein 7

chr7_-_44548733 1.529 ENSMUST00000145956.1
ENSMUST00000049343.8
Pold1

polymerase (DNA directed), delta 1, catalytic subunit

chr2_+_72476159 1.520 ENSMUST00000102691.4
Cdca7
cell division cycle associated 7
chr13_+_22035821 1.497 ENSMUST00000110455.2
Hist1h2bk
histone cluster 1, H2bk
chr14_-_54641347 1.426 ENSMUST00000067784.6
Cdh24
cadherin-like 24
chr15_-_81871883 1.400 ENSMUST00000023117.8
Phf5a
PHD finger protein 5A
chr18_+_56707725 1.371 ENSMUST00000025486.8
Lmnb1
lamin B1
chr1_-_180813591 1.362 ENSMUST00000162118.1
ENSMUST00000159685.1
ENSMUST00000161308.1
H3f3a


H3 histone, family 3A


chr13_-_21810190 1.326 ENSMUST00000110469.1
ENSMUST00000091749.2
Hist1h2bq

histone cluster 1, H2bq

chr1_+_180568913 1.289 ENSMUST00000027777.6
Parp1
poly (ADP-ribose) polymerase family, member 1
chr2_+_18672384 1.269 ENSMUST00000171845.1
ENSMUST00000061158.4
Commd3

COMM domain containing 3

chr13_-_55329723 1.238 ENSMUST00000021941.7
Mxd3
Max dimerization protein 3
chr10_+_11281304 1.233 ENSMUST00000129456.1
Fbxo30
F-box protein 30
chr13_-_22035589 1.223 ENSMUST00000091742.4
Hist1h2ah
histone cluster 1, H2ah
chr2_+_130667610 1.193 ENSMUST00000103193.4
Itpa
inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
chr7_+_28169744 1.190 ENSMUST00000042405.6
Fbl
fibrillarin
chr7_+_110122299 1.161 ENSMUST00000033326.8
Wee1
WEE 1 homolog 1 (S. pombe)
chr13_+_21716385 1.124 ENSMUST00000070124.3
Hist1h2ai
histone cluster 1, H2ai
chr10_-_35711891 1.093 ENSMUST00000080898.2
Amd2
S-adenosylmethionine decarboxylase 2
chr8_+_72319033 1.066 ENSMUST00000067912.7
Klf2
Kruppel-like factor 2 (lung)
chr16_+_38346986 1.046 ENSMUST00000050273.8
ENSMUST00000120495.1
ENSMUST00000119704.1
Cox17

Gm21987
cytochrome c oxidase assembly protein 17

predicted gene 21987
chr12_+_112146187 1.045 ENSMUST00000128402.2
Kif26a
kinesin family member 26A
chr4_+_124714776 1.026 ENSMUST00000030734.4
Sf3a3
splicing factor 3a, subunit 3
chrX_-_37085402 1.019 ENSMUST00000115231.3
Rpl39
ribosomal protein L39
chr13_-_21753851 0.992 ENSMUST00000074752.2
Hist1h2ak
histone cluster 1, H2ak
chr4_+_94739276 0.986 ENSMUST00000073939.6
ENSMUST00000102798.1
Tek

endothelial-specific receptor tyrosine kinase

chr6_+_15721087 0.985 ENSMUST00000120512.1
Mdfic
MyoD family inhibitor domain containing
chr2_-_180920925 0.982 ENSMUST00000037299.8
ENSMUST00000108876.2
Ythdf1

YTH domain family 1

chr12_-_73286698 0.974 ENSMUST00000116420.2
Trmt5
TRM5 tRNA methyltransferase 5
chr11_-_87404380 0.943 ENSMUST00000067692.6
Rad51c
RAD51 homolog C
chr17_-_25792284 0.877 ENSMUST00000072735.7
Fam173a
family with sequence similarity 173, member A
chr11_-_61762040 0.870 ENSMUST00000004955.7
ENSMUST00000168115.1
Prpsap2

phosphoribosyl pyrophosphate synthetase-associated protein 2

chr17_-_12916345 0.849 ENSMUST00000079121.3
Mrpl18
mitochondrial ribosomal protein L18
chr10_+_91082940 0.815 ENSMUST00000020150.3
Ikbip
IKBKB interacting protein
chr2_+_72476225 0.769 ENSMUST00000157019.1
Cdca7
cell division cycle associated 7
chr7_+_66109474 0.757 ENSMUST00000036372.6
Chsy1
chondroitin sulfate synthase 1
chr13_+_23555023 0.752 ENSMUST00000045301.6
Hist1h1d
histone cluster 1, H1d
chr1_+_172521044 0.741 ENSMUST00000085894.5
ENSMUST00000161140.1
ENSMUST00000162988.1
Ccdc19


coiled-coil domain containing 19


chr11_+_88047693 0.729 ENSMUST00000079866.4
Srsf1
serine/arginine-rich splicing factor 1
chr17_+_34850373 0.670 ENSMUST00000097343.4
ENSMUST00000173357.1
ENSMUST00000173065.1
ENSMUST00000165953.2
Nelfe



negative elongation factor complex member E, Rdbp



chr1_+_74506044 0.668 ENSMUST00000087215.5
Rqcd1
rcd1 (required for cell differentiation) homolog 1 (S. pombe)
chr7_-_44816586 0.640 ENSMUST00000047356.8
Atf5
activating transcription factor 5
chr13_+_23574381 0.582 ENSMUST00000090776.4
Hist1h2ad
histone cluster 1, H2ad
chr13_-_97198351 0.569 ENSMUST00000022169.7
Hexb
hexosaminidase B
chr1_-_191183244 0.563 ENSMUST00000027941.8
Atf3
activating transcription factor 3
chr7_+_44816088 0.540 ENSMUST00000057195.9
ENSMUST00000107891.1
Nup62

nucleoporin 62

chr19_+_8723478 0.532 ENSMUST00000180819.1
ENSMUST00000181422.1
Snhg1

small nucleolar RNA host gene (non-protein coding) 1

chr17_+_28691342 0.530 ENSMUST00000114758.1
ENSMUST00000004990.6
ENSMUST00000062694.8
ENSMUST00000114754.1
Mapk14



mitogen-activated protein kinase 14



chr6_-_30509738 0.455 ENSMUST00000115160.3
Tmem209
transmembrane protein 209
chr11_+_43681998 0.437 ENSMUST00000061070.5
Pwwp2a
PWWP domain containing 2A
chr4_+_126556935 0.392 ENSMUST00000048391.8
Clspn
claspin
chr9_+_44334685 0.385 ENSMUST00000052686.2
H2afx
H2A histone family, member X
chr11_+_88047302 0.379 ENSMUST00000139129.2
Srsf1
serine/arginine-rich splicing factor 1
chr10_+_11281583 0.375 ENSMUST00000070300.4
Fbxo30
F-box protein 30
chr5_+_129941949 0.357 ENSMUST00000051758.7
ENSMUST00000073945.4
Vkorc1l1

vitamin K epoxide reductase complex, subunit 1-like 1

chr14_-_54253907 0.351 ENSMUST00000128231.1
Dad1
defender against cell death 1
chr17_+_12916329 0.332 ENSMUST00000089024.6
ENSMUST00000151287.1
ENSMUST00000143961.1
Tcp1


t-complex protein 1


chr7_-_142578139 0.320 ENSMUST00000136359.1
H19
H19 fetal liver mRNA
chr14_-_37135126 0.316 ENSMUST00000042564.9
Ghitm
growth hormone inducible transmembrane protein
chr4_-_108579330 0.310 ENSMUST00000079213.5
Prpf38a
PRP38 pre-mRNA processing factor 38 (yeast) domain containing A
chr12_-_11265768 0.299 ENSMUST00000166117.1
Gen1
Gen homolog 1, endonuclease (Drosophila)
chr5_-_92348871 0.190 ENSMUST00000038816.6
ENSMUST00000118006.1
Cxcl10

chemokine (C-X-C motif) ligand 10

chr17_-_35121990 0.186 ENSMUST00000173915.1
ENSMUST00000172765.2
Csnk2b

casein kinase 2, beta polypeptide

chr13_-_23574196 0.160 ENSMUST00000105106.1
Hist1h2bf
histone cluster 1, H2bf
chr17_+_33524170 0.107 ENSMUST00000087623.6
Adamts10
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 10
chr10_-_117376955 0.073 ENSMUST00000069168.6
ENSMUST00000176686.1
Cpsf6

cleavage and polyadenylation specific factor 6

chr1_-_156474249 0.032 ENSMUST00000051396.6
Soat1
sterol O-acyltransferase 1
chr6_-_30509706 0.006 ENSMUST00000064330.6
ENSMUST00000102991.2
ENSMUST00000115157.1
ENSMUST00000148638.1
Tmem209



transmembrane protein 209




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 7.1 GO:0045218 zonula adherens maintenance(GO:0045218)
1.1 4.4 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.6 2.8 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.5 1.5 GO:0045004 DNA replication proofreading(GO:0045004)
0.5 2.5 GO:0048631 regulation of skeletal muscle tissue growth(GO:0048631)
0.5 2.5 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
0.5 1.4 GO:0031660 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662)
0.4 7.8 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.4 1.3 GO:1904760 myofibroblast differentiation(GO:0036446) regulation of myofibroblast differentiation(GO:1904760)
0.4 1.9 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
0.4 3.7 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.4 4.4 GO:0002227 innate immune response in mucosa(GO:0002227)
0.4 1.1 GO:0006597 spermine biosynthetic process(GO:0006597)
0.3 1.0 GO:1904959 regulation of electron carrier activity(GO:1904732) regulation of cytochrome-c oxidase activity(GO:1904959)
0.3 1.4 GO:1902340 telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340)
0.3 1.0 GO:0048014 Tie signaling pathway(GO:0048014)
0.3 2.1 GO:1990086 lens fiber cell apoptotic process(GO:1990086)
0.3 2.3 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.3 0.8 GO:0035928 rRNA import into mitochondrion(GO:0035928)
0.3 3.5 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.3 1.9 GO:0048478 replication fork protection(GO:0048478)
0.3 2.3 GO:0090166 Golgi disassembly(GO:0090166)
0.2 1.0 GO:1900864 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.2 1.2 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
0.2 0.9 GO:0007066 female meiosis sister chromatid cohesion(GO:0007066)
0.2 6.4 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.2 0.6 GO:0007341 penetration of zona pellucida(GO:0007341)
0.2 0.5 GO:1903490 regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490)
0.2 1.1 GO:0071499 response to laminar fluid shear stress(GO:0034616) cellular response to laminar fluid shear stress(GO:0071499)
0.2 0.5 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835)
0.2 2.7 GO:0051382 kinetochore assembly(GO:0051382)
0.2 1.2 GO:0009146 purine nucleoside triphosphate catabolic process(GO:0009146)
0.2 2.4 GO:0000212 meiotic spindle organization(GO:0000212)
0.1 0.6 GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.1 1.0 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.1 0.4 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.1 2.5 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.1 0.8 GO:0016584 nucleosome positioning(GO:0016584)
0.1 2.0 GO:0043486 histone exchange(GO:0043486)
0.1 10.5 GO:0006342 chromatin silencing(GO:0006342)
0.1 2.6 GO:0006270 DNA replication initiation(GO:0006270)
0.1 1.0 GO:0048484 enteric nervous system development(GO:0048484)
0.1 0.8 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.1 2.6 GO:0090224 regulation of mitotic spindle organization(GO:0060236) regulation of spindle organization(GO:0090224)
0.1 2.1 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.1 0.7 GO:1900364 negative regulation of mRNA polyadenylation(GO:1900364)
0.1 0.3 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
0.1 0.2 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.1 0.3 GO:2000653 regulation of genetic imprinting(GO:2000653)
0.0 1.0 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.0 1.0 GO:0050434 positive regulation of viral transcription(GO:0050434)
0.0 2.5 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.0 1.9 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.0 0.3 GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
0.0 0.3 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.0 1.7 GO:0034605 cellular response to heat(GO:0034605)
0.0 2.0 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.6 GO:1902750 negative regulation of cell cycle G2/M phase transition(GO:1902750)
0.0 0.2 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 7.8 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.8 2.3 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.8 6.1 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.6 7.1 GO:0005915 zonula adherens(GO:0005915)
0.6 2.5 GO:0090661 box H/ACA telomerase RNP complex(GO:0090661)
0.5 1.5 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.3 1.9 GO:0031298 replication fork protection complex(GO:0031298)
0.3 1.2 GO:0001651 dense fibrillar component(GO:0001651)
0.3 4.2 GO:0042555 MCM complex(GO:0042555)
0.2 7.7 GO:0000788 nuclear nucleosome(GO:0000788)
0.2 0.9 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.2 7.5 GO:0000786 nucleosome(GO:0000786)
0.2 1.4 GO:0005638 lamin filament(GO:0005638)
0.2 0.9 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063) Holliday junction resolvase complex(GO:0048476)
0.2 2.5 GO:0005662 DNA replication factor A complex(GO:0005662)
0.2 0.7 GO:0032021 NELF complex(GO:0032021)
0.1 4.3 GO:0005876 spindle microtubule(GO:0005876)
0.1 1.4 GO:0005686 U2 snRNP(GO:0005686)
0.1 1.7 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 0.5 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.1 0.6 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.1 0.8 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.2 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.0 2.4 GO:0072686 mitotic spindle(GO:0072686)
0.0 1.0 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.3 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.4 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 2.7 GO:0000776 kinetochore(GO:0000776)
0.0 1.0 GO:0005871 kinesin complex(GO:0005871)
0.0 3.4 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 1.3 GO:0032993 protein-DNA complex(GO:0032993)
0.0 1.0 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 0.3 GO:0071011 precatalytic spliceosome(GO:0071011)
0.0 0.8 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 4.5 GO:0016607 nuclear speck(GO:0016607)
0.0 1.0 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 1.0 GO:0009925 basal plasma membrane(GO:0009925)
0.0 1.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.9 GO:0005741 mitochondrial outer membrane(GO:0005741)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 7.8 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.7 8.5 GO:0070097 delta-catenin binding(GO:0070097)
0.7 2.8 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.4 2.1 GO:0043515 kinetochore binding(GO:0043515)
0.4 2.3 GO:0070883 pre-miRNA binding(GO:0070883)
0.4 2.5 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.3 4.4 GO:0003688 DNA replication origin binding(GO:0003688)
0.3 1.2 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.3 1.1 GO:0019808 polyamine binding(GO:0019808)
0.3 0.8 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.2 3.4 GO:0035173 histone kinase activity(GO:0035173)
0.2 0.9 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.2 1.3 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.2 1.0 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.2 1.5 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.2 1.2 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.2 2.0 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.1 1.2 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.1 1.0 GO:0016531 copper chaperone activity(GO:0016531)
0.1 1.0 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.1 1.0 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.1 0.6 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.1 0.5 GO:0051425 PTB domain binding(GO:0051425)
0.1 4.8 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 1.0 GO:0030957 Tat protein binding(GO:0030957)
0.1 0.5 GO:0051525 NFAT protein binding(GO:0051525)
0.1 0.8 GO:0008097 5S rRNA binding(GO:0008097)
0.1 1.9 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 1.4 GO:0043274 phospholipase binding(GO:0043274)
0.1 1.9 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 0.3 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.0 0.2 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.0 2.6 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.4 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.4 GO:0048038 quinone binding(GO:0048038)
0.0 1.2 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 3.4 GO:0031072 heat shock protein binding(GO:0031072)
0.0 4.1 GO:0001047 core promoter binding(GO:0001047)
0.0 1.1 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 2.9 GO:0042393 histone binding(GO:0042393)
0.0 0.8 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 1.0 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.3 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 6.3 GO:0046982 protein heterodimerization activity(GO:0046982)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.6 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2 16.2 PID_E2F_PATHWAY E2F transcription factor network
0.2 6.4 PID_ATR_PATHWAY ATR signaling pathway
0.1 5.8 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 7.1 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 1.3 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.6 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.0 1.4 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 1.5 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 2.2 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 2.8 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 2.6 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.4 PID_ATM_PATHWAY ATM pathway
0.0 0.2 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway
0.0 1.0 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 2.1 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.8 7.9 REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.5 6.3 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.5 7.8 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.4 4.0 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.3 11.1 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.2 4.8 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.2 5.5 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 1.2 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 1.9 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.1 2.3 REACTOME_MICRORNA_MIRNA_BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.1 0.6 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.8 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 1.0 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 2.5 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 1.4 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.0 1.0 REACTOME_KINESINS Genes involved in Kinesins
0.0 0.8 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 1.3 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.5 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events
0.0 1.0 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.6 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.4 REACTOME_MEIOSIS Genes involved in Meiosis
0.0 1.0 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.5 REACTOME_TRANSPORT_OF_RIBONUCLEOPROTEINS_INTO_THE_HOST_NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0 0.3 REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC