Motif ID: Foxo6

Z-value: 0.635


Transcription factors associated with Foxo6:

Gene SymbolEntrez IDGene Name
Foxo6 ENSMUSG00000052135.8 Foxo6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxo6mm10_v2_chr4_-_120287349_120287349-0.532.5e-02Click!


Activity profile for motif Foxo6.

activity profile for motif Foxo6


Sorted Z-values histogram for motif Foxo6

Sorted Z-values for motif Foxo6



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxo6

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_12027958 2.063 ENSMUST00000109654.1
Grb10
growth factor receptor bound protein 10
chr6_-_23248264 2.005 ENSMUST00000031709.5
Fezf1
Fez family zinc finger 1
chr1_+_51987139 1.519 ENSMUST00000168302.1
Stat4
signal transducer and activator of transcription 4
chr5_+_110330697 1.416 ENSMUST00000112481.1
Pole
polymerase (DNA directed), epsilon
chr19_-_45742873 1.397 ENSMUST00000026241.5
ENSMUST00000026240.7
ENSMUST00000111928.1
Fgf8


fibroblast growth factor 8


chrX_+_106920618 1.346 ENSMUST00000060576.7
Lpar4
lysophosphatidic acid receptor 4
chrX_-_163761323 1.239 ENSMUST00000059320.2
Rnf138rt1
ring finger protein 138, retrogene 1
chr17_-_31277327 1.196 ENSMUST00000024832.7
Rsph1
radial spoke head 1 homolog (Chlamydomonas)
chr1_+_110099295 1.186 ENSMUST00000134301.1
Cdh7
cadherin 7, type 2
chr5_-_99037035 1.091 ENSMUST00000031277.6
Prkg2
protein kinase, cGMP-dependent, type II
chr4_+_134510999 1.025 ENSMUST00000105866.2
Aunip
aurora kinase A and ninein interacting protein
chrX_-_8193387 1.025 ENSMUST00000143223.1
ENSMUST00000033509.8
Ebp

phenylalkylamine Ca2+ antagonist (emopamil) binding protein

chr5_+_7179299 0.984 ENSMUST00000179460.1
Tubb4b-ps1
tubulin, beta 4B class IVB, pseudogene 1
chr1_+_74391479 0.973 ENSMUST00000027367.7
Ctdsp1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr14_-_47418407 0.934 ENSMUST00000043296.3
Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr7_+_28808795 0.880 ENSMUST00000172529.1
Hnrnpl
heterogeneous nuclear ribonucleoprotein L
chr5_-_117389029 0.873 ENSMUST00000111953.1
ENSMUST00000086461.6
Rfc5

replication factor C (activator 1) 5

chr17_-_24696147 0.830 ENSMUST00000046839.8
Gfer
growth factor, erv1 (S. cerevisiae)-like (augmenter of liver regeneration)
chrY_-_6681243 0.803 ENSMUST00000115940.1
Gm21719
predicted gene, 21719
chrX_+_134585644 0.779 ENSMUST00000113211.1
Rpl36a
ribosomal protein L36A
chr15_-_81843699 0.715 ENSMUST00000092020.2
Gm8444
predicted gene 8444
chr1_-_162898665 0.632 ENSMUST00000111510.1
ENSMUST00000045902.6
Fmo2

flavin containing monooxygenase 2

chr17_-_57839233 0.616 ENSMUST00000095218.3
Rpl7a-ps5
ribosomal protein L7A, pseudogene 5
chr12_-_84617326 0.610 ENSMUST00000021666.4
Abcd4
ATP-binding cassette, sub-family D (ALD), member 4
chr5_-_65391408 0.599 ENSMUST00000057885.6
Rpl9
ribosomal protein L9
chr12_-_91384403 0.585 ENSMUST00000141429.1
Cep128
centrosomal protein 128
chr2_-_67194695 0.561 ENSMUST00000147939.1
Gm13598
predicted gene 13598
chr3_-_51408925 0.560 ENSMUST00000038108.6
Ndufc1
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1
chr5_-_65391380 0.558 ENSMUST00000120094.1
ENSMUST00000118543.1
ENSMUST00000127874.1
Rpl9


ribosomal protein L9


chr7_-_123369870 0.543 ENSMUST00000106442.2
ENSMUST00000098060.3
ENSMUST00000167309.1
Arhgap17


Rho GTPase activating protein 17


chr11_+_46235460 0.529 ENSMUST00000060185.2
Fndc9
fibronectin type III domain containing 9
chr2_-_11603192 0.525 ENSMUST00000040314.5
Rbm17
RNA binding motif protein 17
chr15_+_52712434 0.443 ENSMUST00000037115.7
Med30
mediator complex subunit 30
chr15_-_75111684 0.443 ENSMUST00000100542.3
Ly6c2
lymphocyte antigen 6 complex, locus C2
chr14_-_50924626 0.416 ENSMUST00000160375.1
ENSMUST00000162177.1
ENSMUST00000159292.1
Osgep


O-sialoglycoprotein endopeptidase


chr3_-_34351685 0.403 ENSMUST00000174114.1
Gm20514
predicted gene 20514
chr11_-_89639631 0.401 ENSMUST00000128717.1
Ankfn1
ankyrin-repeat and fibronectin type III domain containing 1
chr7_+_140881898 0.365 ENSMUST00000026560.7
Psmd13
proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
chr19_+_44293676 0.346 ENSMUST00000026221.5
Scd2
stearoyl-Coenzyme A desaturase 2
chr7_+_28440927 0.340 ENSMUST00000078845.6
Gmfg
glia maturation factor, gamma
chr2_+_129593195 0.337 ENSMUST00000099113.3
ENSMUST00000103202.3
Sirpa

signal-regulatory protein alpha

chr14_+_34170640 0.328 ENSMUST00000104925.3
Rpl23a-ps3
ribosomal protein L23A, pseudogene 3
chr7_+_62476306 0.322 ENSMUST00000097132.3
Atp5l-ps1
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g, pseudogene 1
chr18_-_31911903 0.311 ENSMUST00000054984.6
Sft2d3
SFT2 domain containing 3
chr13_-_71963713 0.309 ENSMUST00000077337.8
Irx1
Iroquois related homeobox 1 (Drosophila)
chr3_+_103968110 0.308 ENSMUST00000117150.1
ENSMUST00000063717.7
ENSMUST00000055425.8
ENSMUST00000123611.1
ENSMUST00000090685.4
Phtf1




putative homeodomain transcription factor 1




chr10_-_93310963 0.296 ENSMUST00000151153.1
Elk3
ELK3, member of ETS oncogene family
chr2_+_129592914 0.295 ENSMUST00000103203.1
Sirpa
signal-regulatory protein alpha
chr5_+_44100442 0.289 ENSMUST00000072800.4
Gm16401
predicted gene 16401
chr16_+_10812915 0.280 ENSMUST00000115822.1
Gm11172
predicted gene 11172
chr10_-_93311073 0.277 ENSMUST00000008542.5
Elk3
ELK3, member of ETS oncogene family
chr2_-_155357392 0.275 ENSMUST00000165234.1
ENSMUST00000077626.6
Pigu

phosphatidylinositol glycan anchor biosynthesis, class U

chr1_-_160077918 0.263 ENSMUST00000028061.3
4930562F07Rik
RIKEN cDNA 4930562F07 gene
chr2_+_4718145 0.261 ENSMUST00000056914.6
Bend7
BEN domain containing 7
chr3_-_106167564 0.252 ENSMUST00000063062.8
Chi3l3
chitinase 3-like 3
chr8_+_83566671 0.247 ENSMUST00000036996.5
Ndufb7
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7
chr12_-_113260217 0.218 ENSMUST00000178282.1
Igha
immunoglobulin heavy constant alpha
chr11_+_87853207 0.209 ENSMUST00000038196.6
Mks1
Meckel syndrome, type 1
chr12_+_108410542 0.192 ENSMUST00000054955.7
Eml1
echinoderm microtubule associated protein like 1
chr19_+_8892987 0.190 ENSMUST00000096249.5
Ints5
integrator complex subunit 5
chr5_+_65391497 0.189 ENSMUST00000031101.3
ENSMUST00000122026.1
Lias

lipoic acid synthetase

chr2_-_84425258 0.174 ENSMUST00000074262.2
Calcrl
calcitonin receptor-like
chr18_-_60648290 0.171 ENSMUST00000143275.2
Synpo
synaptopodin
chr8_+_46986913 0.168 ENSMUST00000039840.7
ENSMUST00000119686.1
Enpp6

ectonucleotide pyrophosphatase/phosphodiesterase 6

chr9_+_6168638 0.149 ENSMUST00000058692.7
Pdgfd
platelet-derived growth factor, D polypeptide
chr5_-_52190484 0.144 ENSMUST00000031061.7
Dhx15
DEAH (Asp-Glu-Ala-His) box polypeptide 15
chr5_+_115279666 0.143 ENSMUST00000040421.4
Coq5
coenzyme Q5 homolog, methyltransferase (yeast)
chr15_+_103453782 0.122 ENSMUST00000047405.7
Nckap1l
NCK associated protein 1 like
chr17_+_25471564 0.120 ENSMUST00000025002.1
Tekt4
tektin 4
chr17_+_48346465 0.115 ENSMUST00000113237.3
Trem2
triggering receptor expressed on myeloid cells 2
chr10_+_29313164 0.093 ENSMUST00000160399.1
Echdc1
enoyl Coenzyme A hydratase domain containing 1
chr3_-_127780461 0.091 ENSMUST00000029662.5
ENSMUST00000161239.1
Alpk1

alpha-kinase 1

chr7_+_143052739 0.078 ENSMUST00000037941.9
Cd81
CD81 antigen
chr9_-_22071345 0.070 ENSMUST00000179605.1
ENSMUST00000043922.6
Zfp653

zinc finger protein 653

chr6_+_88724667 0.070 ENSMUST00000163271.1
Mgll
monoglyceride lipase
chrX_+_103493769 0.047 ENSMUST00000182447.1
ENSMUST00000182486.1
Jpx

Jpx transcript, Xist activator (non-protein coding)

chr5_+_115605642 0.047 ENSMUST00000094427.3
Gcn1l1
GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
chr7_+_19368498 0.046 ENSMUST00000132655.1
Ppp1r13l
protein phosphatase 1, regulatory (inhibitor) subunit 13 like
chr16_+_44943737 0.026 ENSMUST00000114622.3
ENSMUST00000166731.1
Cd200r3

CD200 receptor 3

chr3_-_49757257 0.006 ENSMUST00000035931.7
Pcdh18
protocadherin 18
chr2_-_75978164 0.004 ENSMUST00000099995.3
Ttc30a2
tetratricopeptide repeat domain 30A2
chr12_-_102423741 0.003 ENSMUST00000110020.1
Lgmn
legumain

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0045004 DNA replication proofreading(GO:0045004)
0.5 1.4 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.3 2.0 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.2 2.1 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.2 0.6 GO:0072592 oxygen metabolic process(GO:0072592)
0.2 1.1 GO:2001225 cellular hypotonic response(GO:0071476) regulation of chloride transport(GO:2001225)
0.1 0.4 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.1 0.6 GO:0009235 cobalamin metabolic process(GO:0009235)
0.1 0.9 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.1 0.9 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.1 0.3 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.1 0.3 GO:0072272 proximal/distal pattern formation involved in metanephric nephron development(GO:0072272)
0.1 0.8 GO:0097421 liver regeneration(GO:0097421)
0.1 0.2 GO:0009106 lipoate metabolic process(GO:0009106)
0.1 1.3 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.1 0.2 GO:0098886 modification of dendritic spine(GO:0098886)
0.0 0.1 GO:0071673 monocyte extravasation(GO:0035696) positive regulation of smooth muscle cell chemotaxis(GO:0071673) regulation of monocyte extravasation(GO:2000437)
0.0 0.3 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
0.0 0.3 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.4 GO:0050957 equilibrioception(GO:0050957)
0.0 0.2 GO:0034285 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.0 0.1 GO:2001187 positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.0 0.1 GO:0002586 positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002582) regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002586) positive regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002588) detection of peptidoglycan(GO:0032499)
0.0 0.8 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.2 GO:0019695 choline metabolic process(GO:0019695)
0.0 0.2 GO:0061009 common bile duct development(GO:0061009)
0.0 0.4 GO:0043248 proteasome assembly(GO:0043248)
0.0 1.2 GO:0035082 axoneme assembly(GO:0035082)
0.0 0.1 GO:0060294 cilium movement involved in cell motility(GO:0060294)
0.0 0.8 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 1.2 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 1.0 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.0 1.0 GO:1902653 cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653)
0.0 0.1 GO:1904352 positive regulation of protein catabolic process in the vacuole(GO:1904352)
0.0 1.2 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.1 1.2 GO:0001520 outer dense fiber(GO:0001520)
0.1 0.9 GO:0005663 DNA replication factor C complex(GO:0005663)
0.1 0.4 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.0 0.9 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.3 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.9 GO:0045120 pronucleus(GO:0045120)
0.0 0.1 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.0 0.2 GO:0097444 spine apparatus(GO:0097444)
0.0 0.4 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 1.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.2 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.8 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 1.7 GO:0000922 spindle pole(GO:0000922)
0.0 0.2 GO:0036038 MKS complex(GO:0036038)
0.0 0.2 GO:0032039 integrator complex(GO:0032039)
0.0 0.4 GO:0016592 mediator complex(GO:0016592)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.5 1.4 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.3 1.0 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.3 1.1 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.2 0.8 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.2 1.3 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.1 0.6 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.1 0.4 GO:0061711 N(6)-L-threonylcarbamoyladenine synthase(GO:0061711)
0.1 0.6 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 1.0 GO:0008420 CTD phosphatase activity(GO:0008420)
0.1 0.9 GO:1990715 mRNA CDS binding(GO:1990715)
0.1 0.3 GO:0032896 palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.1 0.9 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 0.2 GO:0016979 lipoate-protein ligase activity(GO:0016979)
0.1 0.3 GO:0034235 GPI anchor binding(GO:0034235)
0.1 2.1 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.1 GO:0004492 methylmalonyl-CoA decarboxylase activity(GO:0004492)
0.0 1.2 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.1 GO:0070891 peptidoglycan binding(GO:0042834) lipoteichoic acid binding(GO:0070891)
0.0 0.3 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.2 GO:0097642 calcitonin family receptor activity(GO:0097642)
0.0 0.2 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0 1.2 GO:0019843 rRNA binding(GO:0019843)
0.0 0.2 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.4 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.0 0.6 GO:0045309 protein phosphorylated amino acid binding(GO:0045309)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 1.5 PID_IL27_PATHWAY IL27-mediated signaling events
0.0 2.1 PID_IGF1_PATHWAY IGF1 pathway
0.0 1.0 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.9 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 1.4 PID_FGF_PATHWAY FGF signaling pathway
0.0 0.9 PID_ATR_PATHWAY ATR signaling pathway
0.0 1.0 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.2 2.3 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.1 1.3 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.1 2.1 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.1 1.1 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.6 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 1.0 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.2 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.6 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 1.9 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.0 0.8 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.8 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport