Motif ID: Maf_Nrl

Z-value: 0.572

Transcription factors associated with Maf_Nrl:

Gene SymbolEntrez IDGene Name
Maf ENSMUSG00000055435.6 Maf
Nrl ENSMUSG00000040632.9 Nrl

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mafmm10_v2_chr8_-_115707778_115707794-0.135.9e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Maf_Nrl

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_4710119 2.247 ENSMUST00000105588.1
ENSMUST00000105589.1
Esr1

estrogen receptor 1 (alpha)

chr7_-_103853199 1.538 ENSMUST00000033229.3
Hbb-y
hemoglobin Y, beta-like embryonic chain
chr16_-_23890805 1.450 ENSMUST00000004480.3
Sst
somatostatin
chr1_+_90203980 1.424 ENSMUST00000065587.4
ENSMUST00000159654.1
Ackr3

atypical chemokine receptor 3

chr10_+_56377300 1.031 ENSMUST00000068581.7
Gja1
gap junction protein, alpha 1
chr13_+_48261427 0.900 ENSMUST00000021810.1
Id4
inhibitor of DNA binding 4
chr7_-_75308373 0.874 ENSMUST00000085164.5
Sv2b
synaptic vesicle glycoprotein 2 b
chr7_+_121707189 0.871 ENSMUST00000065310.2
1700069B07Rik
RIKEN cDNA 1700069B07 gene
chr2_-_156887172 0.770 ENSMUST00000109561.3
Sla2
Src-like-adaptor 2
chr2_-_156887056 0.723 ENSMUST00000029164.2
Sla2
Src-like-adaptor 2
chr4_-_135573623 0.661 ENSMUST00000105855.1
Grhl3
grainyhead-like 3 (Drosophila)
chr15_-_93519499 0.638 ENSMUST00000109255.2
Prickle1
prickle homolog 1 (Drosophila)
chr11_+_76202084 0.617 ENSMUST00000169560.1
Fam57a
family with sequence similarity 57, member A
chr11_+_76202007 0.606 ENSMUST00000094014.3
Fam57a
family with sequence similarity 57, member A
chr18_-_61707583 0.587 ENSMUST00000025472.1
Pcyox1l
prenylcysteine oxidase 1 like
chr12_-_111672290 0.574 ENSMUST00000001304.7
Ckb
creatine kinase, brain
chr3_-_79145875 0.553 ENSMUST00000118340.1
Rapgef2
Rap guanine nucleotide exchange factor (GEF) 2
chr14_-_49525840 0.547 ENSMUST00000138884.1
ENSMUST00000074368.4
ENSMUST00000123534.1
Slc35f4


solute carrier family 35, member F4


chr8_-_64693027 0.536 ENSMUST00000048967.7
Cpe
carboxypeptidase E
chr8_+_94666722 0.512 ENSMUST00000034228.8
Arl2bp
ADP-ribosylation factor-like 2 binding protein
chr16_+_30065333 0.472 ENSMUST00000023171.7
Hes1
hairy and enhancer of split 1 (Drosophila)
chr15_-_42676967 0.472 ENSMUST00000022921.5
Angpt1
angiopoietin 1
chr11_-_79059872 0.463 ENSMUST00000141409.1
Ksr1
kinase suppressor of ras 1
chr16_+_78930940 0.437 ENSMUST00000114216.1
ENSMUST00000069148.6
ENSMUST00000023568.7
Chodl


chondrolectin


chr1_+_129273344 0.434 ENSMUST00000073527.6
ENSMUST00000040311.7
Thsd7b

thrombospondin, type I, domain containing 7B

chr17_-_70851710 0.433 ENSMUST00000166395.2
Tgif1
TGFB-induced factor homeobox 1
chr15_-_67113909 0.430 ENSMUST00000092640.5
St3gal1
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr1_+_62703285 0.427 ENSMUST00000102822.2
ENSMUST00000075144.5
Nrp2

neuropilin 2

chr1_-_183147461 0.425 ENSMUST00000171366.1
Disp1
dispatched homolog 1 (Drosophila)
chr1_-_118982551 0.417 ENSMUST00000159678.1
Gli2
GLI-Kruppel family member GLI2
chr6_-_138422898 0.410 ENSMUST00000161450.1
ENSMUST00000163024.1
ENSMUST00000162185.1
Lmo3


LIM domain only 3


chr7_-_70360593 0.401 ENSMUST00000032768.7
Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr17_-_89910449 0.384 ENSMUST00000086423.4
Gm10184
predicted pseudogene 10184
chr9_-_114844090 0.383 ENSMUST00000047013.3
Cmtm8
CKLF-like MARVEL transmembrane domain containing 8
chr9_+_87022014 0.360 ENSMUST00000168529.2
ENSMUST00000174724.1
ENSMUST00000173126.1
Cyb5r4


cytochrome b5 reductase 4


chr4_+_14864076 0.358 ENSMUST00000029875.3
Tmem55a
transmembrane protein 55A
chr11_+_76945719 0.347 ENSMUST00000125145.1
Blmh
bleomycin hydrolase
chr10_-_30842765 0.347 ENSMUST00000019924.8
Hey2
hairy/enhancer-of-split related with YRPW motif 2
chr7_+_82337218 0.338 ENSMUST00000173828.1
Adamtsl3
ADAMTS-like 3
chr13_+_113342548 0.337 ENSMUST00000078163.7
BC067074
cDNA sequence BC067074
chr10_-_42583628 0.337 ENSMUST00000019938.4
Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr2_+_120476911 0.329 ENSMUST00000110716.1
ENSMUST00000028748.6
ENSMUST00000090028.5
ENSMUST00000110719.2
Capn3



calpain 3



chr9_+_96895617 0.314 ENSMUST00000071781.6
Gm10123
predicted pseudogene 10123
chr9_+_49102720 0.312 ENSMUST00000070390.5
ENSMUST00000167095.1
Tmprss5

transmembrane protease, serine 5 (spinesin)

chr8_+_94667082 0.311 ENSMUST00000109527.4
Arl2bp
ADP-ribosylation factor-like 2 binding protein
chr11_-_65788275 0.304 ENSMUST00000152096.1
ENSMUST00000046963.3
Map2k4

mitogen-activated protein kinase kinase 4

chr3_+_95228732 0.294 ENSMUST00000053872.5
Cdc42se1
CDC42 small effector 1
chr7_-_103843154 0.292 ENSMUST00000063957.4
Hbb-bh1
hemoglobin Z, beta-like embryonic chain
chr3_-_33083016 0.288 ENSMUST00000078226.3
ENSMUST00000108224.1
Pex5l

peroxisomal biogenesis factor 5-like

chr10_+_116143881 0.283 ENSMUST00000105271.2
Ptprr
protein tyrosine phosphatase, receptor type, R
chr4_+_101507947 0.279 ENSMUST00000149047.1
ENSMUST00000106929.3
Dnajc6

DnaJ (Hsp40) homolog, subfamily C, member 6

chr3_-_33082004 0.275 ENSMUST00000108225.3
Pex5l
peroxisomal biogenesis factor 5-like
chr19_-_24861828 0.271 ENSMUST00000047666.4
Pgm5
phosphoglucomutase 5
chr12_+_108605757 0.269 ENSMUST00000109854.2
Evl
Ena-vasodilator stimulated phosphoprotein
chr11_+_87663087 0.267 ENSMUST00000165679.1
Rnf43
ring finger protein 43
chr10_+_69213084 0.265 ENSMUST00000163497.1
ENSMUST00000164212.1
ENSMUST00000067908.7
Rhobtb1


Rho-related BTB domain containing 1


chr10_+_69212634 0.265 ENSMUST00000020101.5
Rhobtb1
Rho-related BTB domain containing 1
chr4_+_101507855 0.247 ENSMUST00000038207.5
Dnajc6
DnaJ (Hsp40) homolog, subfamily C, member 6
chrX_-_8074720 0.245 ENSMUST00000115636.3
ENSMUST00000115638.3
Suv39h1

suppressor of variegation 3-9 homolog 1 (Drosophila)

chr10_+_87859255 0.244 ENSMUST00000105300.2
Igf1
insulin-like growth factor 1
chr10_-_127060163 0.232 ENSMUST00000040307.5
March9
membrane-associated ring finger (C3HC4) 9
chr11_+_80428598 0.230 ENSMUST00000173938.1
ENSMUST00000017572.7
Psmd11

proteasome (prosome, macropain) 26S subunit, non-ATPase, 11

chr19_-_21652779 0.229 ENSMUST00000179768.1
ENSMUST00000178523.1
ENSMUST00000038830.3
1110059E24Rik


RIKEN cDNA 1110059E24 gene


chr5_-_24730635 0.226 ENSMUST00000068693.5
Wdr86
WD repeat domain 86
chr16_+_90386382 0.219 ENSMUST00000065856.6
Hunk
hormonally upregulated Neu-associated kinase
chr5_+_24423851 0.214 ENSMUST00000141966.1
Slc4a2
solute carrier family 4 (anion exchanger), member 2
chr2_+_181767040 0.212 ENSMUST00000108756.1
Myt1
myelin transcription factor 1
chr10_+_96616998 0.207 ENSMUST00000038377.7
Btg1
B cell translocation gene 1, anti-proliferative
chr19_-_6118491 0.207 ENSMUST00000113533.1
Sac3d1
SAC3 domain containing 1
chr9_-_63399216 0.205 ENSMUST00000168665.1
2300009A05Rik
RIKEN cDNA 2300009A05 gene
chr2_-_140671462 0.202 ENSMUST00000110057.2
Flrt3
fibronectin leucine rich transmembrane protein 3
chr8_-_69974367 0.200 ENSMUST00000116463.2
Gatad2a
GATA zinc finger domain containing 2A
chr6_+_55037988 0.197 ENSMUST00000003572.8
Gars
glycyl-tRNA synthetase
chr4_+_94739276 0.197 ENSMUST00000073939.6
ENSMUST00000102798.1
Tek

endothelial-specific receptor tyrosine kinase

chr4_+_155522462 0.194 ENSMUST00000177094.1
Gnb1
guanine nucleotide binding protein (G protein), beta 1
chr2_+_181767283 0.194 ENSMUST00000108757.2
Myt1
myelin transcription factor 1
chr1_+_58646608 0.194 ENSMUST00000081455.4
Gm10068
predicted gene 10068
chr16_-_46155077 0.193 ENSMUST00000059524.5
Gm4737
predicted gene 4737
chr11_-_115699461 0.191 ENSMUST00000106497.1
Grb2
growth factor receptor bound protein 2
chr7_-_110862944 0.190 ENSMUST00000033050.3
Lyve1
lymphatic vessel endothelial hyaluronan receptor 1
chr14_-_73385225 0.190 ENSMUST00000022704.7
Itm2b
integral membrane protein 2B
chr2_+_59160838 0.190 ENSMUST00000102754.4
ENSMUST00000168631.1
ENSMUST00000123908.1
Pkp4


plakophilin 4


chr2_+_118900377 0.187 ENSMUST00000151162.1
Bahd1
bromo adjacent homology domain containing 1
chr14_+_116925379 0.186 ENSMUST00000088483.3
Gpc6
glypican 6
chr3_-_58525867 0.185 ENSMUST00000029385.7
Serp1
stress-associated endoplasmic reticulum protein 1
chr4_+_155839724 0.185 ENSMUST00000030947.3
Mxra8
matrix-remodelling associated 8
chr6_-_92481343 0.179 ENSMUST00000113445.1
Prickle2
prickle homolog 2 (Drosophila)
chr2_+_151543877 0.178 ENSMUST00000142271.1
Fkbp1a
FK506 binding protein 1a
chr11_+_69991633 0.176 ENSMUST00000108592.1
Gabarap
gamma-aminobutyric acid receptor associated protein
chr18_-_43059418 0.176 ENSMUST00000025377.7
Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr11_+_69324069 0.176 ENSMUST00000060956.6
ENSMUST00000108662.1
Trappc1

trafficking protein particle complex 1

chr9_+_75051977 0.175 ENSMUST00000170310.1
ENSMUST00000166549.1
Arpp19

cAMP-regulated phosphoprotein 19

chr19_+_55894508 0.173 ENSMUST00000142291.1
Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr11_+_82035569 0.171 ENSMUST00000000193.5
Ccl2
chemokine (C-C motif) ligand 2
chr11_-_115699307 0.168 ENSMUST00000106499.1
Grb2
growth factor receptor bound protein 2
chr3_-_95228636 0.167 ENSMUST00000065482.5
Mllt11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr3_-_141931523 0.167 ENSMUST00000106232.1
Bmpr1b
bone morphogenetic protein receptor, type 1B
chr9_-_99140065 0.166 ENSMUST00000035037.7
Pik3cb
phosphatidylinositol 3-kinase, catalytic, beta polypeptide
chr1_+_110099295 0.166 ENSMUST00000134301.1
Cdh7
cadherin 7, type 2
chr1_+_180568913 0.165 ENSMUST00000027777.6
Parp1
poly (ADP-ribose) polymerase family, member 1
chr8_+_72135247 0.165 ENSMUST00000003575.9
Tpm4
tropomyosin 4
chr16_+_64851991 0.165 ENSMUST00000067744.7
Cggbp1
CGG triplet repeat binding protein 1
chr2_-_151632471 0.164 ENSMUST00000137936.1
ENSMUST00000146172.1
ENSMUST00000094456.3
ENSMUST00000148755.1
ENSMUST00000109875.1
ENSMUST00000028951.7
ENSMUST00000109877.3
Snph






syntaphilin






chr16_+_20672716 0.163 ENSMUST00000044783.7
ENSMUST00000115463.1
ENSMUST00000142344.1
ENSMUST00000073840.5
ENSMUST00000140576.1
ENSMUST00000115457.1
Eif4g1





eukaryotic translation initiation factor 4, gamma 1





chr2_+_119799514 0.161 ENSMUST00000028763.9
Tyro3
TYRO3 protein tyrosine kinase 3
chr11_-_77725281 0.161 ENSMUST00000078623.4
Cryba1
crystallin, beta A1
chr19_+_38264761 0.161 ENSMUST00000087252.5
Lgi1
leucine-rich repeat LGI family, member 1
chr19_+_20601958 0.160 ENSMUST00000087638.3
Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
chrX_-_163761323 0.159 ENSMUST00000059320.2
Rnf138rt1
ring finger protein 138, retrogene 1
chr16_+_13358375 0.159 ENSMUST00000149359.1
Mkl2
MKL/myocardin-like 2
chr2_-_118373347 0.156 ENSMUST00000039160.2
Gpr176
G protein-coupled receptor 176
chr6_-_76497631 0.155 ENSMUST00000097218.5
Gm9008
predicted pseudogene 9008
chr15_+_89453913 0.155 ENSMUST00000023291.5
Mapk8ip2
mitogen-activated protein kinase 8 interacting protein 2
chr2_+_34772089 0.154 ENSMUST00000028222.6
ENSMUST00000100171.2
Hspa5

heat shock protein 5

chr11_+_69324055 0.154 ENSMUST00000102601.3
Trappc1
trafficking protein particle complex 1
chr3_-_146839365 0.151 ENSMUST00000084614.3
Gm10288
predicted gene 10288
chr11_-_86683761 0.150 ENSMUST00000018315.3
Vmp1
vacuole membrane protein 1
chr7_+_66839726 0.148 ENSMUST00000098382.3
Adamts17
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 17
chr4_+_141242850 0.147 ENSMUST00000138096.1
ENSMUST00000006618.2
ENSMUST00000125392.1
Arhgef19


Rho guanine nucleotide exchange factor (GEF) 19


chr7_-_45052865 0.147 ENSMUST00000057293.6
Prr12
proline rich 12
chr6_-_99520949 0.145 ENSMUST00000176565.1
Foxp1
forkhead box P1
chr6_+_110645572 0.145 ENSMUST00000071076.6
ENSMUST00000172951.1
Grm7

glutamate receptor, metabotropic 7

chr12_-_15816762 0.145 ENSMUST00000020922.7
Trib2
tribbles homolog 2 (Drosophila)
chr7_+_66839752 0.144 ENSMUST00000107478.1
Adamts17
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 17
chr11_+_120232921 0.142 ENSMUST00000122148.1
ENSMUST00000044985.7
Bahcc1

BAH domain and coiled-coil containing 1

chr14_-_57746044 0.141 ENSMUST00000173990.1
ENSMUST00000022531.7
Lats2

large tumor suppressor 2

chr3_+_105959369 0.140 ENSMUST00000010278.5
Wdr77
WD repeat domain 77
chr10_+_79910856 0.138 ENSMUST00000181321.1
Gm26602
predicted gene, 26602
chr2_+_130277157 0.136 ENSMUST00000028890.8
ENSMUST00000159373.1
Nop56

NOP56 ribonucleoprotein

chr17_+_9422060 0.133 ENSMUST00000076982.6
Gm17728
predicted gene, 17728
chr5_+_112255813 0.133 ENSMUST00000031286.6
ENSMUST00000131673.1
ENSMUST00000112375.1
Crybb1


crystallin, beta B1


chr7_+_28267809 0.130 ENSMUST00000059596.6
Eid2
EP300 interacting inhibitor of differentiation 2
chr2_+_59160884 0.129 ENSMUST00000037903.8
Pkp4
plakophilin 4
chr6_-_99435345 0.129 ENSMUST00000113322.2
ENSMUST00000176850.1
ENSMUST00000176632.1
Foxp1


forkhead box P1


chr17_+_29614786 0.128 ENSMUST00000024817.7
Rnf8
ring finger protein 8
chr5_+_53590453 0.127 ENSMUST00000113865.1
Rbpj
recombination signal binding protein for immunoglobulin kappa J region
chr17_-_84187939 0.126 ENSMUST00000060366.6
Zfp36l2
zinc finger protein 36, C3H type-like 2
chr8_-_124897685 0.125 ENSMUST00000098312.2
Exoc8
exocyst complex component 8
chr5_+_147188678 0.125 ENSMUST00000065382.5
Gsx1
GS homeobox 1
chr12_+_80644212 0.121 ENSMUST00000085245.5
Slc39a9
solute carrier family 39 (zinc transporter), member 9
chr7_-_141902361 0.121 ENSMUST00000055819.6
ENSMUST00000130439.1
ENSMUST00000001950.5
Tollip


toll interacting protein


chr19_-_20727533 0.120 ENSMUST00000025656.3
Aldh1a7
aldehyde dehydrogenase family 1, subfamily A7
chr2_+_52038005 0.119 ENSMUST00000065927.5
Tnfaip6
tumor necrosis factor alpha induced protein 6
chr19_+_60755947 0.118 ENSMUST00000088237.4
Nanos1
nanos homolog 1 (Drosophila)
chr10_+_83360206 0.118 ENSMUST00000020488.7
D10Wsu102e
DNA segment, Chr 10, Wayne State University 102, expressed
chr3_-_104961695 0.116 ENSMUST00000029429.4
Wnt2b
wingless related MMTV integration site 2b
chr17_-_34122311 0.116 ENSMUST00000025193.6
Brd2
bromodomain containing 2
chr2_+_85136355 0.114 ENSMUST00000057019.7
Aplnr
apelin receptor
chr14_+_116925291 0.114 ENSMUST00000078849.4
Gpc6
glypican 6
chr14_+_116925516 0.112 ENSMUST00000125435.1
Gpc6
glypican 6
chr7_+_51879041 0.112 ENSMUST00000107591.2
Gas2
growth arrest specific 2
chr12_-_113361232 0.111 ENSMUST00000103423.1
Ighg3
Immunoglobulin heavy constant gamma 3
chr11_-_100135928 0.110 ENSMUST00000107411.2
Krt15
keratin 15
chr4_+_43578921 0.108 ENSMUST00000030190.8
Rgp1
RGP1 retrograde golgi transport homolog (S. cerevisiae)
chr7_+_51878967 0.108 ENSMUST00000051912.6
Gas2
growth arrest specific 2
chr2_-_30093642 0.107 ENSMUST00000102865.4
Zdhhc12
zinc finger, DHHC domain containing 12
chr2_+_181763315 0.105 ENSMUST00000081125.4
Myt1
myelin transcription factor 1
chr1_+_92906959 0.105 ENSMUST00000060913.6
Dusp28
dual specificity phosphatase 28
chr2_+_153031852 0.103 ENSMUST00000037235.6
Xkr7
X Kell blood group precursor related family member 7 homolog
chr2_-_30830333 0.103 ENSMUST00000041726.3
Asb6
ankyrin repeat and SOCS box-containing 6
chr14_-_102982630 0.101 ENSMUST00000184744.1
KCTD12
mmu-mir-5130
chr6_-_99521153 0.101 ENSMUST00000177227.1
Foxp1
forkhead box P1
chr5_+_110544326 0.101 ENSMUST00000040001.7
Galnt9
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9
chr2_-_181691771 0.099 ENSMUST00000108778.1
ENSMUST00000165416.1
Rgs19

regulator of G-protein signaling 19

chr7_+_29309429 0.097 ENSMUST00000137848.1
Dpf1
D4, zinc and double PHD fingers family 1
chr12_+_30584429 0.096 ENSMUST00000057151.8
Tmem18
transmembrane protein 18
chr3_+_96832142 0.094 ENSMUST00000107070.1
ENSMUST00000107069.1
Pdzk1

PDZ domain containing 1

chr11_+_69323963 0.093 ENSMUST00000102602.1
Trappc1
trafficking protein particle complex 1
chr10_+_43221466 0.091 ENSMUST00000095725.4
Pdss2
prenyl (solanesyl) diphosphate synthase, subunit 2
chr16_+_8830093 0.087 ENSMUST00000023150.5
1810013L24Rik
RIKEN cDNA 1810013L24 gene
chr7_+_127769809 0.086 ENSMUST00000118865.1
ENSMUST00000061587.6
ENSMUST00000121504.1
Orai3


ORAI calcium release-activated calcium modulator 3


chr6_-_39118211 0.086 ENSMUST00000038398.6
Parp12
poly (ADP-ribose) polymerase family, member 12
chrX_-_18461371 0.085 ENSMUST00000044188.4
4930578C19Rik
RIKEN cDNA 4930578C19 gene
chr15_-_56694525 0.084 ENSMUST00000050544.7
Has2
hyaluronan synthase 2
chr17_+_48409980 0.083 ENSMUST00000167180.1
ENSMUST00000046651.6
Oard1

O-acyl-ADP-ribose deacylase 1

chr16_+_94570010 0.079 ENSMUST00000119878.1
Dyrk1a
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a
chr9_-_73968901 0.078 ENSMUST00000184666.1
Unc13c
unc-13 homolog C (C. elegans)
chr16_-_89508313 0.078 ENSMUST00000056118.2
Krtap7-1
keratin associated protein 7-1
chr2_-_30093607 0.078 ENSMUST00000081838.6
Zdhhc12
zinc finger, DHHC domain containing 12
chr2_+_18064645 0.078 ENSMUST00000114680.2
Mllt10
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
chr13_-_53473074 0.078 ENSMUST00000021922.8
Msx2
msh homeobox 2
chr1_+_127306706 0.078 ENSMUST00000171405.1
Mgat5
mannoside acetylglucosaminyltransferase 5
chr7_+_97400003 0.078 ENSMUST00000032882.8
Ndufc2
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2
chr14_-_70635946 0.077 ENSMUST00000022695.9
Dmtn
dematin actin binding protein
chr17_+_24896488 0.077 ENSMUST00000024978.6
Nme3
NME/NM23 nucleoside diphosphate kinase 3
chr17_+_29614800 0.073 ENSMUST00000162588.1
Rnf8
ring finger protein 8
chr7_+_99267428 0.073 ENSMUST00000068973.4
ENSMUST00000122101.1
Map6

microtubule-associated protein 6

chr10_-_127311740 0.072 ENSMUST00000037290.5
ENSMUST00000171564.1
Mars

methionine-tRNA synthetase

chr7_+_19228334 0.071 ENSMUST00000063976.8
Opa3
optic atrophy 3
chrX_+_13280970 0.068 ENSMUST00000000804.6
Ddx3x
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked
chr14_+_120478443 0.067 ENSMUST00000062117.6
Rap2a
RAS related protein 2a
chrX_-_134600976 0.067 ENSMUST00000033621.6
Gla
galactosidase, alpha
chr18_-_35655185 0.066 ENSMUST00000097619.1
Prob1
proline rich basic protein 1
chr2_-_27142429 0.066 ENSMUST00000151224.2
Fam163b
family with sequence similarity 163, member B
chr4_-_126202583 0.066 ENSMUST00000106142.1
ENSMUST00000169403.1
ENSMUST00000130334.1
Thrap3


thyroid hormone receptor associated protein 3


chr1_-_45503282 0.066 ENSMUST00000086430.4
Col5a2
collagen, type V, alpha 2
chr7_-_99483645 0.066 ENSMUST00000107096.1
ENSMUST00000032998.6
Rps3

ribosomal protein S3

chr12_-_85824506 0.065 ENSMUST00000021676.5
ENSMUST00000142331.1
0610007P14Rik

RIKEN cDNA 0610007P14 gene

chr9_+_110052016 0.063 ENSMUST00000164930.1
ENSMUST00000163979.1
Map4

microtubule-associated protein 4

chr2_-_118479635 0.062 ENSMUST00000110862.1
ENSMUST00000009693.8
Srp14

signal recognition particle 14


Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.2 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.4 1.8 GO:0015671 oxygen transport(GO:0015671)
0.3 1.0 GO:0003104 positive regulation of glomerular filtration(GO:0003104) cell communication by chemical coupling(GO:0010643)
0.3 1.1 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
0.2 0.7 GO:0048014 Tie signaling pathway(GO:0048014)
0.2 0.6 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.2 0.8 GO:0035905 ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
0.2 0.6 GO:0030327 prenylated protein catabolic process(GO:0030327)
0.2 0.6 GO:2000670 positive regulation of dendritic cell apoptotic process(GO:2000670)
0.2 0.5 GO:0030070 insulin processing(GO:0030070)
0.1 0.4 GO:0021649 vestibulocochlear nerve structural organization(GO:0021649) ganglion morphogenesis(GO:0061552) dorsal root ganglion morphogenesis(GO:1904835)
0.1 0.3 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
0.1 1.5 GO:0050849 negative regulation of calcium-mediated signaling(GO:0050849)
0.1 0.4 GO:0060032 notochord regression(GO:0060032)
0.1 0.6 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.1 0.5 GO:0072318 clathrin coat disassembly(GO:0072318)
0.1 0.3 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.1 0.9 GO:0060539 diaphragm development(GO:0060539)
0.1 0.6 GO:0051461 protein import into peroxisome matrix, docking(GO:0016560) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.1 0.4 GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.1 0.4 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.1 0.3 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.1 0.2 GO:0003345 proepicardium cell migration involved in pericardium morphogenesis(GO:0003345)
0.1 0.3 GO:0021764 amygdala development(GO:0021764)
0.1 0.2 GO:0001830 trophectodermal cell fate commitment(GO:0001830)
0.1 0.2 GO:1904760 myofibroblast differentiation(GO:0036446) regulation of myofibroblast differentiation(GO:1904760)
0.1 0.3 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.1 0.2 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.1 0.2 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.1 0.3 GO:0034393 positive regulation of smooth muscle cell apoptotic process(GO:0034393) negative regulation of motor neuron apoptotic process(GO:2000672)
0.1 0.2 GO:0021506 anterior neuropore closure(GO:0021506) neuropore closure(GO:0021995)
0.0 0.2 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.0 0.1 GO:0001827 inner cell mass cell fate commitment(GO:0001827)
0.0 0.2 GO:0060857 establishment of glial blood-brain barrier(GO:0060857)
0.0 0.3 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.0 0.1 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
0.0 0.1 GO:0072554 arterial endothelial cell fate commitment(GO:0060844) blood vessel endothelial cell fate commitment(GO:0060846) endothelial cell fate specification(GO:0060847) Notch signaling pathway involved in arterial endothelial cell fate commitment(GO:0060853) canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:0061317) blood vessel lumenization(GO:0072554) regulation of heart induction(GO:0090381) blood vessel endothelial cell fate specification(GO:0097101) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) positive regulation of heart induction(GO:1901321) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066)
0.0 0.2 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.0 0.2 GO:0070535 histone H2A K63-linked ubiquitination(GO:0070535)
0.0 0.2 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.0 0.2 GO:0015960 diadenosine polyphosphate biosynthetic process(GO:0015960) diadenosine tetraphosphate metabolic process(GO:0015965) diadenosine tetraphosphate biosynthetic process(GO:0015966)
0.0 0.7 GO:0090179 planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.0 0.2 GO:0007603 phototransduction, visible light(GO:0007603)
0.0 0.1 GO:0051795 positive regulation of catagen(GO:0051795)
0.0 0.1 GO:0060423 foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492)
0.0 1.4 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)
0.0 0.1 GO:0002030 inhibitory G-protein coupled receptor phosphorylation(GO:0002030)
0.0 0.4 GO:0061470 interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619)
0.0 0.1 GO:0001661 conditioned taste aversion(GO:0001661)
0.0 0.8 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.0 0.2 GO:2000427 eosinophil chemotaxis(GO:0048245) T cell extravasation(GO:0072683) positive regulation of apoptotic cell clearance(GO:2000427)
0.0 0.1 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.0 0.2 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
0.0 0.4 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.2 GO:2000210 positive regulation of anoikis(GO:2000210)
0.0 0.1 GO:0035585 calcium-mediated signaling using extracellular calcium source(GO:0035585)
0.0 0.2 GO:0010908 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334)
0.0 0.2 GO:0036123 histone H3-K9 dimethylation(GO:0036123)
0.0 0.4 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.0 0.2 GO:0060347 heart trabecula formation(GO:0060347)
0.0 0.1 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.0 0.3 GO:0031507 heterochromatin assembly(GO:0031507)
0.0 0.1 GO:1905051 regulation of base-excision repair(GO:1905051) positive regulation of base-excision repair(GO:1905053)
0.0 0.2 GO:0006027 glycosaminoglycan catabolic process(GO:0006027)
0.0 0.1 GO:0001927 exocyst assembly(GO:0001927)
0.0 0.1 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0 0.2 GO:0051901 positive regulation of mitochondrial depolarization(GO:0051901)
0.0 0.2 GO:0060068 vagina development(GO:0060068)
0.0 0.1 GO:0032693 negative regulation of interleukin-10 production(GO:0032693)
0.0 0.2 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0 0.0 GO:0015920 regulation of phosphatidylcholine catabolic process(GO:0010899) lipopolysaccharide transport(GO:0015920)
0.0 0.1 GO:1904627 response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)
0.0 0.1 GO:0042573 retinoic acid metabolic process(GO:0042573)
0.0 0.2 GO:2000507 positive regulation of energy homeostasis(GO:2000507)
0.0 0.2 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0 0.1 GO:1901838 positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838)
0.0 0.2 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.2 GO:0046958 nonassociative learning(GO:0046958)
0.0 0.4 GO:0010975 regulation of neuron projection development(GO:0010975)
0.0 0.1 GO:0015879 carnitine transport(GO:0015879)
0.0 0.4 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.1 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.0 GO:0072272 proximal/distal pattern formation involved in metanephric nephron development(GO:0072272)
0.0 0.1 GO:0042256 mature ribosome assembly(GO:0042256)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.2 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.2 1.8 GO:0005833 hemoglobin complex(GO:0005833)
0.1 0.6 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.1 1.0 GO:0005916 fascia adherens(GO:0005916)
0.1 0.4 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.1 0.2 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.1 0.2 GO:0044299 C-fiber(GO:0044299)
0.1 0.6 GO:0005677 chromatin silencing complex(GO:0005677)
0.0 0.5 GO:0031045 dense core granule(GO:0031045)
0.0 0.4 GO:0097542 ciliary tip(GO:0097542)
0.0 0.3 GO:0030057 desmosome(GO:0030057)
0.0 0.4 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.1 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.2 GO:0071664 beta-catenin-TCF7L2 complex(GO:0070369) catenin-TCF7L2 complex(GO:0071664)
0.0 0.1 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.2 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.2 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.1 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 0.2 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.3 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.3 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.3 GO:0000421 autophagosome membrane(GO:0000421)
0.0 0.1 GO:0034709 methylosome(GO:0034709)
0.0 0.1 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.1 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 0.3 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.1 GO:0044305 calyx of Held(GO:0044305)
0.0 0.1 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.2 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.2 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 1.0 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 2.0 GO:0005770 late endosome(GO:0005770)
0.0 0.3 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.8 GO:0005902 microvillus(GO:0005902)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.2 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.5 1.4 GO:0016494 C-X-C chemokine receptor activity(GO:0016494) C-X-C chemokine binding(GO:0019958)
0.5 1.8 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.3 1.0 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) gap junction channel activity involved in cell communication by electrical coupling(GO:1903763)
0.1 0.6 GO:0004111 creatine kinase activity(GO:0004111)
0.1 0.4 GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597)
0.1 0.3 GO:0035939 microsatellite binding(GO:0035939)
0.1 0.6 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.1 0.4 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1 0.6 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670)
0.1 0.6 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1 0.4 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.1 0.3 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.1 0.5 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 1.9 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.1 GO:0070905 serine binding(GO:0070905)
0.0 0.4 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.2 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.0 0.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.5 GO:0050897 cobalt ion binding(GO:0050897)
0.0 0.3 GO:0031432 titin binding(GO:0031432)
0.0 0.4 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0 0.3 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 0.9 GO:0008432 JUN kinase binding(GO:0008432)
0.0 0.3 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.2 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.0 0.5 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.1 GO:0005124 scavenger receptor binding(GO:0005124)
0.0 0.4 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.2 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 0.4 GO:0015197 peptide transporter activity(GO:0015197)
0.0 0.1 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.2 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0 0.1 GO:0001565 phorbol ester receptor activity(GO:0001565) non-kinase phorbol ester receptor activity(GO:0001566)
0.0 0.1 GO:0050347 trans-hexaprenyltranstransferase activity(GO:0000010) trans-octaprenyltranstransferase activity(GO:0050347)
0.0 0.1 GO:0008534 oxidized purine nucleobase lesion DNA N-glycosylase activity(GO:0008534)
0.0 0.0 GO:0005128 erythropoietin receptor binding(GO:0005128)
0.0 1.3 GO:0005179 hormone activity(GO:0005179)
0.0 0.2 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0 0.2 GO:0048185 activin binding(GO:0048185)
0.0 0.2 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.2 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.4 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.2 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.0 0.3 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.0 GO:0046978 TAP1 binding(GO:0046978) TAP2 binding(GO:0046979)
0.0 0.0 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.0 0.2 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.1 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.0 0.2 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.1 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.0 0.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.0 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.1 GO:0016936 galactoside binding(GO:0016936)
0.0 0.5 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.0 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling
0.0 1.2 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.4 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 0.3 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 1.5 PID_TCR_PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.4 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.6 PID_SHP2_PATHWAY SHP2 signaling
0.0 0.2 PID_ALK2_PATHWAY ALK2 signaling events
0.0 0.7 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.1 2.2 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.1 1.2 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.4 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.2 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.0 0.2 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.4 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.7 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 1.7 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.2 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.4 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.0 0.2 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.6 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 0.6 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.1 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.5 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.3 REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 0.3 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.0 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.2 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.2 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins