Motif ID: Hoxd1

Z-value: 0.714


Transcription factors associated with Hoxd1:

Gene SymbolEntrez IDGene Name
Hoxd1 ENSMUSG00000042448.4 Hoxd1



Activity profile for motif Hoxd1.

activity profile for motif Hoxd1


Sorted Z-values histogram for motif Hoxd1

Sorted Z-values for motif Hoxd1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxd1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_-_110000219 2.344 ENSMUST00000032719.7
Nav3
neuron navigator 3
chr2_-_20943413 2.269 ENSMUST00000140230.1
Arhgap21
Rho GTPase activating protein 21
chrX_-_143933089 2.266 ENSMUST00000087313.3
Dcx
doublecortin
chr15_-_8710409 2.038 ENSMUST00000157065.1
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr1_-_158356258 1.740 ENSMUST00000004133.8
Brinp2
bone morphogenic protein/retinoic acid inducible neural-specific 2
chr5_+_107497762 1.657 ENSMUST00000152474.1
ENSMUST00000060553.7
A830010M20Rik

RIKEN cDNA A830010M20 gene

chr16_+_11406618 1.627 ENSMUST00000122168.1
Snx29
sorting nexin 29
chr4_+_102570065 1.499 ENSMUST00000097950.2
Pde4b
phosphodiesterase 4B, cAMP specific
chr2_+_69897255 1.458 ENSMUST00000131553.1
Ubr3
ubiquitin protein ligase E3 component n-recognin 3
chr9_-_123851855 1.409 ENSMUST00000184082.1
ENSMUST00000167595.2
Fyco1

FYVE and coiled-coil domain containing 1

chr2_+_3424123 1.386 ENSMUST00000061852.5
ENSMUST00000100463.3
ENSMUST00000102988.3
ENSMUST00000115066.1
Dclre1c



DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae)



chr3_-_85722474 1.382 ENSMUST00000119077.1
Fam160a1
family with sequence similarity 160, member A1
chr5_+_107497718 1.342 ENSMUST00000112671.2
A830010M20Rik
RIKEN cDNA A830010M20 gene
chr2_+_170731807 1.321 ENSMUST00000029075.4
Dok5
docking protein 5
chr13_-_105054895 1.318 ENSMUST00000063551.5
Rgs7bp
regulator of G-protein signalling 7 binding protein
chr5_-_62766153 1.241 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr7_+_127511976 1.226 ENSMUST00000098025.4
Srcap
Snf2-related CREBBP activator protein
chr9_-_55919605 1.196 ENSMUST00000037408.8
Scaper
S phase cyclin A-associated protein in the ER
chr13_+_42866247 1.165 ENSMUST00000131942.1
Phactr1
phosphatase and actin regulator 1
chr15_-_8710734 1.137 ENSMUST00000005493.7
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr13_+_83732438 1.130 ENSMUST00000182701.1
C130071C03Rik
RIKEN cDNA C130071C03 gene
chr17_-_45659312 1.125 ENSMUST00000120717.1
Capn11
calpain 11
chr12_+_109545390 1.103 ENSMUST00000146701.1
Meg3
maternally expressed 3
chr2_+_65620829 1.088 ENSMUST00000028377.7
Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr8_-_105966038 1.083 ENSMUST00000116429.2
ENSMUST00000034370.9
Slc12a4

solute carrier family 12, member 4

chr7_-_140154712 1.015 ENSMUST00000059241.7
Sprn
shadow of prion protein
chr12_-_98577940 1.004 ENSMUST00000110113.1
Kcnk10
potassium channel, subfamily K, member 10
chr1_+_65186727 0.997 ENSMUST00000097707.4
ENSMUST00000081154.7
Pikfyve

phosphoinositide kinase, FYVE finger containing

chr4_-_14621805 0.995 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chrX_-_143933204 0.991 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
Dcx


doublecortin


chr2_-_156392829 0.989 ENSMUST00000088578.2
2900097C17Rik
RIKEN cDNA 2900097C17 gene
chr9_-_15301555 0.952 ENSMUST00000034414.8
4931406C07Rik
RIKEN cDNA 4931406C07 gene
chr5_+_134932351 0.921 ENSMUST00000047196.7
ENSMUST00000111221.2
ENSMUST00000111219.1
ENSMUST00000068617.5
ENSMUST00000111218.1
ENSMUST00000136246.1
Wbscr27





Williams Beuren syndrome chromosome region 27 (human)





chr8_-_122915987 0.898 ENSMUST00000098333.4
Ankrd11
ankyrin repeat domain 11
chr2_+_119047129 0.895 ENSMUST00000153300.1
ENSMUST00000028799.5
Casc5

cancer susceptibility candidate 5

chr17_-_36032682 0.883 ENSMUST00000102678.4
H2-T23
histocompatibility 2, T region locus 23
chrM_+_9870 0.872 ENSMUST00000084013.1
mt-Nd4l
mitochondrially encoded NADH dehydrogenase 4L
chr9_-_107872403 0.857 ENSMUST00000183035.1
Rbm6
RNA binding motif protein 6
chr2_-_177267036 0.828 ENSMUST00000108963.1
Gm14409
predicted gene 14409
chr5_-_123012874 0.812 ENSMUST00000172729.1
Kdm2b
lysine (K)-specific demethylase 2B
chrX_+_9885622 0.812 ENSMUST00000067529.2
ENSMUST00000086165.3
Sytl5

synaptotagmin-like 5

chr2_+_37516618 0.811 ENSMUST00000065441.6
Gpr21
G protein-coupled receptor 21
chr15_+_25773985 0.811 ENSMUST00000125667.1
Myo10
myosin X
chr2_+_121956651 0.807 ENSMUST00000110574.1
Ctdspl2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr12_+_52699297 0.807 ENSMUST00000095737.3
Akap6
A kinase (PRKA) anchor protein 6
chr8_+_113635550 0.780 ENSMUST00000179926.1
Mon1b
MON1 homolog b (yeast)
chr1_-_24612700 0.775 ENSMUST00000088336.1
Gm10222
predicted gene 10222
chr8_+_113635787 0.763 ENSMUST00000035777.8
Mon1b
MON1 homolog b (yeast)
chr5_-_118244861 0.756 ENSMUST00000117177.1
ENSMUST00000133372.1
ENSMUST00000154786.1
ENSMUST00000121369.1
Rnft2



ring finger protein, transmembrane 2



chr3_-_116712644 0.755 ENSMUST00000029569.2
Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr16_-_55934845 0.744 ENSMUST00000121129.1
ENSMUST00000023270.7
Cep97

centrosomal protein 97

chr5_-_106926245 0.729 ENSMUST00000117588.1
Hfm1
HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)
chr10_+_90071095 0.717 ENSMUST00000183109.1
Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr15_+_82256023 0.710 ENSMUST00000143238.1
1500009C09Rik
RIKEN cDNA 1500009C09 gene
chr12_+_80644212 0.709 ENSMUST00000085245.5
Slc39a9
solute carrier family 39 (zinc transporter), member 9
chr4_-_14621494 0.703 ENSMUST00000149633.1
Slc26a7
solute carrier family 26, member 7
chr17_-_32822200 0.695 ENSMUST00000179695.1
Zfp799
zinc finger protein 799
chr7_-_6730412 0.685 ENSMUST00000051209.4
Peg3
paternally expressed 3
chr18_+_31609512 0.681 ENSMUST00000164667.1
B930094E09Rik
RIKEN cDNA B930094E09 gene
chr2_+_69897220 0.676 ENSMUST00000055758.9
ENSMUST00000112251.2
Ubr3

ubiquitin protein ligase E3 component n-recognin 3

chr8_-_54724474 0.667 ENSMUST00000175915.1
Wdr17
WD repeat domain 17
chr7_+_29816061 0.666 ENSMUST00000032796.6
ENSMUST00000178162.1
Zfp790

zinc finger protein 790

chr6_-_57535422 0.626 ENSMUST00000042766.3
Ppm1k
protein phosphatase 1K (PP2C domain containing)
chr17_+_88440711 0.623 ENSMUST00000112238.2
ENSMUST00000155640.1
Foxn2

forkhead box N2

chr2_+_150323702 0.609 ENSMUST00000133235.2
Gm10130
predicted gene 10130
chr7_+_79273201 0.608 ENSMUST00000037315.6
Abhd2
abhydrolase domain containing 2
chr16_-_55934797 0.590 ENSMUST00000122280.1
ENSMUST00000121703.2
Cep97

centrosomal protein 97

chr5_-_70842617 0.583 ENSMUST00000031119.1
Gabrg1
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1
chr18_+_37355271 0.569 ENSMUST00000051163.1
Pcdhb8
protocadherin beta 8
chr1_-_33814516 0.527 ENSMUST00000044455.5
ENSMUST00000115167.1
Zfp451

zinc finger protein 451

chr2_+_121956411 0.520 ENSMUST00000110578.1
Ctdspl2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr19_+_23723279 0.519 ENSMUST00000067077.1
Gm9938
predicted gene 9938
chr4_+_103143052 0.500 ENSMUST00000106855.1
Mier1
mesoderm induction early response 1 homolog (Xenopus laevis
chr14_+_26259109 0.498 ENSMUST00000174494.1
Duxbl3
double homeobox B-like 3
chrX_-_57338598 0.479 ENSMUST00000033468.4
ENSMUST00000114736.1
Arhgef6

Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6

chr15_+_98092569 0.478 ENSMUST00000163507.1
Pfkm
phosphofructokinase, muscle
chr9_-_86880647 0.472 ENSMUST00000167014.1
Snap91
synaptosomal-associated protein 91
chr18_-_60273267 0.471 ENSMUST00000090260.4
Gm4841
predicted gene 4841
chr7_-_44929410 0.462 ENSMUST00000107857.3
ENSMUST00000085399.6
ENSMUST00000167930.1
ENSMUST00000166972.1
Ap2a1



adaptor-related protein complex 2, alpha 1 subunit



chr8_-_41041828 0.454 ENSMUST00000051379.7
Mtus1
mitochondrial tumor suppressor 1
chr17_+_34931253 0.443 ENSMUST00000007253.5
Neu1
neuraminidase 1
chr5_+_29195983 0.439 ENSMUST00000160888.1
ENSMUST00000159272.1
ENSMUST00000001247.5
ENSMUST00000161398.1
ENSMUST00000160246.1
Rnf32




ring finger protein 32




chr3_+_94837702 0.424 ENSMUST00000107266.1
ENSMUST00000042402.5
ENSMUST00000107269.1
Pogz


pogo transposable element with ZNF domain


chr3_+_103739366 0.419 ENSMUST00000106852.1
Gm10964
predicted gene 10964
chr14_-_75754475 0.412 ENSMUST00000049168.7
Cog3
component of oligomeric golgi complex 3
chr14_+_48446128 0.411 ENSMUST00000124720.1
Tmem260
transmembrane protein 260
chr11_-_121388186 0.404 ENSMUST00000106107.2
Rab40b
Rab40b, member RAS oncogene family
chr2_+_119047116 0.398 ENSMUST00000152380.1
ENSMUST00000099542.2
Casc5

cancer susceptibility candidate 5

chr2_-_116067391 0.388 ENSMUST00000140185.1
2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr19_+_8802486 0.385 ENSMUST00000172175.1
Zbtb3
zinc finger and BTB domain containing 3
chr10_-_117148474 0.380 ENSMUST00000020381.3
Frs2
fibroblast growth factor receptor substrate 2
chr10_+_103367748 0.379 ENSMUST00000074204.4
ENSMUST00000179636.1
Slc6a15

solute carrier family 6 (neurotransmitter transporter), member 15

chr9_-_85749308 0.372 ENSMUST00000039213.8
Ibtk
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr14_+_26119811 0.368 ENSMUST00000173617.1
Duxbl2
doubl homeobox B-like 2
chr11_-_107337556 0.361 ENSMUST00000040380.6
Pitpnc1
phosphatidylinositol transfer protein, cytoplasmic 1
chr14_-_104522615 0.361 ENSMUST00000022716.2
Rnf219
ring finger protein 219
chr16_-_16600533 0.353 ENSMUST00000159542.1
Fgd4
FYVE, RhoGEF and PH domain containing 4
chr14_+_25980039 0.345 ENSMUST00000173155.1
Duxbl1
double homeobox B-like 1
chr2_-_45117349 0.344 ENSMUST00000176438.2
Zeb2
zinc finger E-box binding homeobox 2
chr9_-_119341390 0.340 ENSMUST00000139870.1
Myd88
myeloid differentiation primary response gene 88
chr16_+_52031549 0.339 ENSMUST00000114471.1
Cblb
Casitas B-lineage lymphoma b
chr4_+_146610961 0.339 ENSMUST00000130825.1
Gm13248
predicted gene 13248
chr12_-_24493656 0.326 ENSMUST00000073088.2
Gm16372
predicted pseudogene 16372
chr6_+_72097561 0.314 ENSMUST00000069994.4
ENSMUST00000114112.1
St3gal5

ST3 beta-galactoside alpha-2,3-sialyltransferase 5

chr19_+_3323301 0.311 ENSMUST00000025835.4
Cpt1a
carnitine palmitoyltransferase 1a, liver
chr16_+_65520503 0.307 ENSMUST00000176330.1
ENSMUST00000004964.8
ENSMUST00000176038.1
Pou1f1


POU domain, class 1, transcription factor 1


chr9_+_72958785 0.301 ENSMUST00000098567.2
ENSMUST00000034734.8
Dyx1c1

dyslexia susceptibility 1 candidate 1 homolog (human)

chr1_+_139454747 0.301 ENSMUST00000053364.8
ENSMUST00000097554.3
Aspm

asp (abnormal spindle)-like, microcephaly associated (Drosophila)

chr15_-_37459327 0.298 ENSMUST00000119730.1
ENSMUST00000120746.1
Ncald

neurocalcin delta

chr14_+_4198185 0.297 ENSMUST00000180184.1
Gm2974
predicted gene 2974
chr18_+_59062462 0.284 ENSMUST00000058633.2
ENSMUST00000175897.1
ENSMUST00000118510.1
ENSMUST00000175830.1
A730017C20Rik



RIKEN cDNA A730017C20 gene



chr17_-_57031468 0.284 ENSMUST00000007814.8
Khsrp
KH-type splicing regulatory protein
chr10_+_75037066 0.278 ENSMUST00000147802.1
ENSMUST00000020391.5
Rab36

RAB36, member RAS oncogene family

chr3_+_94837533 0.273 ENSMUST00000107270.2
Pogz
pogo transposable element with ZNF domain
chr17_+_36837123 0.271 ENSMUST00000179968.1
ENSMUST00000130367.1
ENSMUST00000130801.1
ENSMUST00000144182.1
ENSMUST00000123715.1
ENSMUST00000053434.8
Trim26





tripartite motif-containing 26





chr19_-_32196393 0.270 ENSMUST00000151822.1
Sgms1
sphingomyelin synthase 1
chr2_-_84715160 0.262 ENSMUST00000035840.5
Zdhhc5
zinc finger, DHHC domain containing 5
chr5_-_63968867 0.259 ENSMUST00000154169.1
Rell1
RELT-like 1
chr18_-_24603464 0.250 ENSMUST00000154205.1
Slc39a6
solute carrier family 39 (metal ion transporter), member 6
chr2_+_116067213 0.243 ENSMUST00000152412.1
G630016G05Rik
RIKEN cDNA G630016G05 gene
chrX_+_16619698 0.226 ENSMUST00000026013.5
Maoa
monoamine oxidase A
chrX_-_75578188 0.209 ENSMUST00000033545.5
Rab39b
RAB39B, member RAS oncogene family
chr13_-_67332525 0.209 ENSMUST00000168892.1
ENSMUST00000109735.2
Zfp595

zinc finger protein 595

chr7_+_130774069 0.209 ENSMUST00000048453.5
Btbd16
BTB (POZ) domain containing 16
chr4_-_14621669 0.208 ENSMUST00000143105.1
Slc26a7
solute carrier family 26, member 7
chr18_+_12741324 0.203 ENSMUST00000115857.2
ENSMUST00000121018.1
ENSMUST00000119108.1
Cabyr


calcium-binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)


chr14_+_69347587 0.194 ENSMUST00000064831.5
Entpd4
ectonucleoside triphosphate diphosphohydrolase 4
chr5_+_136987019 0.176 ENSMUST00000004968.4
Plod3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr12_+_16653470 0.175 ENSMUST00000111064.1
Ntsr2
neurotensin receptor 2
chr4_-_132075250 0.157 ENSMUST00000105970.1
ENSMUST00000105975.1
Epb4.1

erythrocyte protein band 4.1

chr9_+_53771499 0.155 ENSMUST00000048670.8
Slc35f2
solute carrier family 35, member F2
chr13_+_44121167 0.154 ENSMUST00000163056.1
ENSMUST00000159595.1
Gm5083

predicted gene 5083

chr6_+_34029421 0.147 ENSMUST00000070189.3
ENSMUST00000101564.2
Lrguk

leucine-rich repeats and guanylate kinase domain containing

chr14_+_32321987 0.139 ENSMUST00000022480.7
Ogdhl
oxoglutarate dehydrogenase-like
chr17_-_32886083 0.133 ENSMUST00000178401.1
Zfp870
zinc finger protein 870
chr16_+_34690548 0.132 ENSMUST00000023532.6
Ccdc14
coiled-coil domain containing 14
chr1_-_185329331 0.126 ENSMUST00000027921.4
ENSMUST00000110975.1
ENSMUST00000110974.3
Iars2


isoleucine-tRNA synthetase 2, mitochondrial


chr10_+_94575257 0.123 ENSMUST00000121471.1
Tmcc3
transmembrane and coiled coil domains 3
chr4_+_147492417 0.112 ENSMUST00000105721.2
Gm13152
predicted gene 13152
chr2_-_73580288 0.105 ENSMUST00000028515.3
Chrna1
cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)
chr10_-_112928974 0.101 ENSMUST00000099276.2
Atxn7l3b
ataxin 7-like 3B
chr12_-_87388317 0.093 ENSMUST00000021424.4
Sptlc2
serine palmitoyltransferase, long chain base subunit 2
chr10_-_120112946 0.092 ENSMUST00000020449.5
Helb
helicase (DNA) B
chr18_+_24603952 0.088 ENSMUST00000025120.6
Elp2
elongator acetyltransferase complex subunit 2
chr10_-_86011833 0.087 ENSMUST00000105304.1
ENSMUST00000061699.5
Bpifc

BPI fold containing family C

chr5_+_145204523 0.081 ENSMUST00000085671.3
ENSMUST00000031601.7
Zkscan5

zinc finger with KRAB and SCAN domains 5

chr11_+_32283511 0.078 ENSMUST00000093209.3
Hba-a1
hemoglobin alpha, adult chain 1
chrX_-_75843185 0.064 ENSMUST00000137192.1
Pls3
plastin 3 (T-isoform)
chr8_+_72219726 0.057 ENSMUST00000003123.8
Fam32a
family with sequence similarity 32, member A
chr2_+_172370658 0.041 ENSMUST00000151511.1
ENSMUST00000116375.1
Cstf1

cleavage stimulation factor, 3' pre-RNA, subunit 1

chr1_+_161969284 0.040 ENSMUST00000160881.1
ENSMUST00000159648.1
Pigc

phosphatidylinositol glycan anchor biosynthesis, class C

chr18_+_59062282 0.037 ENSMUST00000165666.2
A730017C20Rik
RIKEN cDNA A730017C20 gene
chr2_-_69712461 0.033 ENSMUST00000102706.3
ENSMUST00000073152.6
Fastkd1

FAST kinase domains 1

chr3_-_41742471 0.032 ENSMUST00000026866.8
Sclt1
sodium channel and clathrin linker 1
chr2_-_150255591 0.024 ENSMUST00000063463.5
Gm21994
predicted gene 21994
chr2_+_69822370 0.021 ENSMUST00000053087.3
Klhl23
kelch-like 23
chr4_+_147132038 0.019 ENSMUST00000084149.3
Gm13139
predicted gene 13139
chr10_-_76110956 0.010 ENSMUST00000120757.1
Slc5a4b
solute carrier family 5 (neutral amino acid transporters, system A), member 4b
chr9_+_119341487 0.002 ENSMUST00000175743.1
ENSMUST00000176397.1
Acaa1a

acetyl-Coenzyme A acyltransferase 1A


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.2 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.5 2.1 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.5 1.5 GO:0019085 early viral transcription(GO:0019085)
0.5 2.3 GO:0051684 maintenance of Golgi location(GO:0051684)
0.3 0.9 GO:2000564 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.3 1.4 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.3 1.9 GO:0019532 oxalate transport(GO:0019532)
0.2 3.3 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.2 0.8 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.2 1.4 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.2 0.8 GO:0021993 initiation of neural tube closure(GO:0021993)
0.2 0.5 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.2 0.8 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.1 1.5 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 0.3 GO:2000616 negative regulation of histone H3-K9 acetylation(GO:2000616)
0.1 0.3 GO:2000338 positive regulation of interleukin-23 production(GO:0032747) chemokine (C-X-C motif) ligand 1 production(GO:0072566) regulation of chemokine (C-X-C motif) ligand 1 production(GO:2000338)
0.1 0.3 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.1 1.3 GO:1902018 regulation of mitotic spindle assembly(GO:1901673) negative regulation of cilium assembly(GO:1902018)
0.1 0.3 GO:0060126 somatotropin secreting cell differentiation(GO:0060126)
0.1 1.0 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 0.4 GO:0046619 optic placode formation involved in camera-type eye formation(GO:0046619)
0.1 0.4 GO:0006689 ganglioside catabolic process(GO:0006689) oligosaccharide catabolic process(GO:0009313)
0.1 1.3 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.1 0.5 GO:0061622 glycolytic process through glucose-1-phosphate(GO:0061622)
0.1 0.4 GO:0015803 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.1 0.3 GO:0051661 maintenance of centrosome location(GO:0051661)
0.1 0.5 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.1 0.7 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.1 0.3 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.1 0.2 GO:0042420 dopamine catabolic process(GO:0042420)
0.1 0.6 GO:0032570 response to progesterone(GO:0032570)
0.0 0.2 GO:0046947 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.0 0.7 GO:0051382 kinetochore assembly(GO:0051382)
0.0 0.1 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.0 0.4 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 1.0 GO:0032288 myelin assembly(GO:0032288)
0.0 0.4 GO:0030035 microspike assembly(GO:0030035)
0.0 1.7 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 0.4 GO:0031937 positive regulation of chromatin silencing(GO:0031937)
0.0 0.3 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.0 0.7 GO:0008340 determination of adult lifespan(GO:0008340)
0.0 0.3 GO:2000628 regulation of miRNA metabolic process(GO:2000628)
0.0 1.0 GO:0006829 zinc II ion transport(GO:0006829)
0.0 0.3 GO:0036159 outer dynein arm assembly(GO:0036158) inner dynein arm assembly(GO:0036159)
0.0 0.3 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.0 0.1 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.0 0.8 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.6 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.9 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.6 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 0.5 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.0 0.8 GO:0040018 positive regulation of multicellular organism growth(GO:0040018)
0.0 0.1 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.0 0.0 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.3 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.0 0.5 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.0 0.4 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.2 GO:0048240 sperm capacitation(GO:0048240)
0.0 0.8 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 1.2 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 0.8 GO:0051489 regulation of filopodium assembly(GO:0051489)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0098835 presynaptic endosome(GO:0098830) presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835)
0.1 0.5 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.1 1.4 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.1 0.6 GO:0097524 sperm plasma membrane(GO:0097524)
0.1 0.9 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 0.2 GO:0097637 intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637)
0.1 0.3 GO:0036449 microtubule minus-end(GO:0036449)
0.1 1.0 GO:0032593 insulin-responsive compartment(GO:0032593)
0.1 1.5 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.8 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.5 GO:0032433 filopodium tip(GO:0032433)
0.0 0.4 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.3 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 2.1 GO:0005776 autophagosome(GO:0005776)
0.0 0.3 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.1 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.9 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.1 GO:0002177 manchette(GO:0002177)
0.0 4.6 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 1.2 GO:0030175 filopodium(GO:0030175)
0.0 0.1 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.1 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 3.3 GO:0030426 growth cone(GO:0030426)
0.0 0.6 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.2 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 1.1 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.4 GO:0016235 aggresome(GO:0016235)
0.0 0.1 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.8 GO:0031519 PcG protein complex(GO:0031519)
0.0 0.3 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.1 GO:0005892 acetylcholine-gated channel complex(GO:0005892)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.2 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.2 0.8 GO:0004952 dopamine neurotransmitter receptor activity(GO:0004952)
0.2 1.9 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.2 1.1 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.2 1.4 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.1 1.0 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.1 0.5 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.1 0.9 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.1 0.4 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.1 1.0 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 0.3 GO:0070976 TIR domain binding(GO:0070976)
0.1 0.3 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.1 0.8 GO:0043495 protein anchor(GO:0043495)
0.1 1.1 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 0.2 GO:0051378 primary amine oxidase activity(GO:0008131) serotonin binding(GO:0051378)
0.1 0.3 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 0.3 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.4 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.0 0.6 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.2 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0 0.8 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 1.4 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.1 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.0 0.5 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 1.2 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.4 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 1.5 GO:0030552 cAMP binding(GO:0030552)
0.0 0.4 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.8 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.0 0.6 GO:0050811 GABA-A receptor activity(GO:0004890) GABA receptor binding(GO:0050811)
0.0 0.1 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 1.3 GO:0005158 insulin receptor binding(GO:0005158)
0.0 0.2 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.0 0.8 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 1.2 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.3 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.1 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 0.1 GO:0031720 haptoglobin binding(GO:0031720)
0.0 0.1 GO:0017116 single-stranded DNA-dependent ATP-dependent DNA helicase activity(GO:0017116)
0.0 0.8 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.5 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.0 0.7 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.8 GO:0030507 spectrin binding(GO:0030507)
0.0 0.8 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.5 GO:0004407 histone deacetylase activity(GO:0004407)
0.0 0.1 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.2 GO:0031489 myosin V binding(GO:0031489)
0.0 0.0 GO:0005402 cation:sugar symporter activity(GO:0005402)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.3 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 1.4 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 1.2 PID_ARF6_PATHWAY Arf6 signaling events
0.0 1.7 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.8 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.5 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.3 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.5 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 1.0 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 6.5 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.3 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION_IN_TLR7_8_OR_9_SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 1.5 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 0.3 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 3.7 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.0 1.3 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.4 REACTOME_PROLONGED_ERK_ACTIVATION_EVENTS Genes involved in Prolonged ERK activation events
0.0 0.5 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.2 REACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.8 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.3 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.3 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.1 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.5 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.0 0.3 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers