Motif ID: Nkx2-4
Z-value: 0.532

Transcription factors associated with Nkx2-4:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Nkx2-4 | ENSMUSG00000054160.2 | Nkx2-4 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Nkx2-4 | mm10_v2_chr2_-_147085445_147085483 | 0.15 | 5.4e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 1.6 | GO:0060745 | mammary gland branching involved in pregnancy(GO:0060745) |
0.3 | 0.9 | GO:0072092 | ureteric bud invasion(GO:0072092) |
0.1 | 0.3 | GO:1904975 | response to bleomycin(GO:1904975) cellular response to bleomycin(GO:1904976) |
0.1 | 0.4 | GO:0090669 | snoRNA guided rRNA pseudouridine synthesis(GO:0000454) telomerase RNA stabilization(GO:0090669) |
0.1 | 0.6 | GO:0071802 | negative regulation of podosome assembly(GO:0071802) |
0.1 | 0.7 | GO:2000741 | positive regulation of mesenchymal stem cell differentiation(GO:2000741) |
0.1 | 0.2 | GO:0051902 | negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180) |
0.0 | 0.1 | GO:0042320 | regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) |
0.0 | 0.4 | GO:0014807 | regulation of somitogenesis(GO:0014807) |
0.0 | 0.2 | GO:0006177 | GMP biosynthetic process(GO:0006177) |
0.0 | 0.4 | GO:0071455 | cellular response to hyperoxia(GO:0071455) |
0.0 | 0.2 | GO:0001661 | conditioned taste aversion(GO:0001661) amygdala development(GO:0021764) |
0.0 | 0.2 | GO:0051182 | coenzyme transport(GO:0051182) |
0.0 | 0.4 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
0.0 | 0.1 | GO:1904139 | microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139) |
0.0 | 0.5 | GO:0003334 | keratinocyte development(GO:0003334) |
0.0 | 1.1 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
0.0 | 0.1 | GO:0038032 | termination of G-protein coupled receptor signaling pathway(GO:0038032) |
0.0 | 0.1 | GO:0031161 | phosphatidylinositol catabolic process(GO:0031161) |
0.0 | 0.7 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
0.0 | 0.1 | GO:2000642 | negative regulation of early endosome to late endosome transport(GO:2000642) |
0.0 | 0.2 | GO:0001675 | acrosome assembly(GO:0001675) |
0.0 | 0.7 | GO:0045104 | intermediate filament cytoskeleton organization(GO:0045104) |
0.0 | 0.2 | GO:0044539 | long-chain fatty acid import(GO:0044539) |
0.0 | 0.2 | GO:0048280 | vesicle fusion with Golgi apparatus(GO:0048280) |
0.0 | 0.1 | GO:0019919 | peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919) |
0.0 | 0.3 | GO:0044804 | nucleophagy(GO:0044804) |
0.0 | 0.2 | GO:0006488 | dolichol-linked oligosaccharide biosynthetic process(GO:0006488) |
0.0 | 0.1 | GO:0045650 | negative regulation of macrophage differentiation(GO:0045650) |
0.0 | 0.1 | GO:0036295 | cellular response to increased oxygen levels(GO:0036295) |
0.0 | 0.2 | GO:0038092 | nodal signaling pathway(GO:0038092) |
0.0 | 0.6 | GO:0048488 | synaptic vesicle endocytosis(GO:0048488) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 0.7 | GO:0044299 | C-fiber(GO:0044299) |
0.2 | 1.6 | GO:0097550 | transcriptional preinitiation complex(GO:0097550) |
0.1 | 0.2 | GO:0034457 | Mpp10 complex(GO:0034457) |
0.0 | 0.4 | GO:0005732 | small nucleolar ribonucleoprotein complex(GO:0005732) |
0.0 | 0.1 | GO:0042406 | extrinsic component of endoplasmic reticulum membrane(GO:0042406) |
0.0 | 0.3 | GO:0031616 | spindle pole centrosome(GO:0031616) |
0.0 | 0.9 | GO:0005871 | kinesin complex(GO:0005871) |
0.0 | 0.2 | GO:0002080 | acrosomal membrane(GO:0002080) |
0.0 | 0.2 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 1.6 | GO:0031798 | type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052) |
0.1 | 0.2 | GO:0043758 | acetate-CoA ligase (ADP-forming) activity(GO:0043758) |
0.1 | 0.2 | GO:0030519 | snoRNP binding(GO:0030519) |
0.0 | 0.2 | GO:0003938 | IMP dehydrogenase activity(GO:0003938) |
0.0 | 0.5 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
0.0 | 0.2 | GO:0051185 | coenzyme transporter activity(GO:0051185) |
0.0 | 0.2 | GO:0071253 | connexin binding(GO:0071253) |
0.0 | 0.6 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
0.0 | 0.4 | GO:0070034 | telomerase RNA binding(GO:0070034) |
0.0 | 0.4 | GO:0035497 | cAMP response element binding(GO:0035497) |
0.0 | 0.6 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
0.0 | 0.1 | GO:0044020 | protein-arginine omega-N monomethyltransferase activity(GO:0035241) histone methyltransferase activity (H4-R3 specific)(GO:0044020) |
0.0 | 0.4 | GO:0001223 | transcription coactivator binding(GO:0001223) |
0.0 | 0.1 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
0.0 | 0.9 | GO:0003777 | microtubule motor activity(GO:0003777) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 1.9 | PID_ER_NONGENOMIC_PATHWAY | Plasma membrane estrogen receptor signaling |
0.0 | 0.3 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
0.0 | 0.5 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
0.0 | 0.4 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
0.0 | 1.0 | PID_RHOA_REG_PATHWAY | Regulation of RhoA activity |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 1.6 | REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
0.0 | 0.3 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
0.0 | 0.2 | REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
0.0 | 0.1 | REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
0.0 | 0.2 | REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
0.0 | 1.0 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
0.0 | 0.1 | REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
0.0 | 0.2 | REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |