Motif ID: Fosb

Z-value: 0.327


Transcription factors associated with Fosb:

Gene SymbolEntrez IDGene Name
Fosb ENSMUSG00000003545.2 Fosb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Fosbmm10_v2_chr7_-_19310035_19310050-0.419.5e-02Click!


Activity profile for motif Fosb.

activity profile for motif Fosb


Sorted Z-values histogram for motif Fosb

Sorted Z-values for motif Fosb



Network of associatons between targets according to the STRING database.



First level regulatory network of Fosb

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_+_80000292 1.069 ENSMUST00000088735.3
Olfm4
olfactomedin 4
chr2_+_118663235 0.871 ENSMUST00000099557.3
Pak6
p21 protein (Cdc42/Rac)-activated kinase 6
chr14_+_27622433 0.740 ENSMUST00000090302.5
Erc2
ELKS/RAB6-interacting/CAST family member 2
chr16_+_17561885 0.602 ENSMUST00000171002.1
ENSMUST00000023441.4
P2rx6

purinergic receptor P2X, ligand-gated ion channel, 6

chr3_+_55461758 0.594 ENSMUST00000070418.4
Dclk1
doublecortin-like kinase 1
chr6_-_124769548 0.559 ENSMUST00000149652.1
ENSMUST00000112476.1
ENSMUST00000004378.8
Eno2


enolase 2, gamma neuronal


chr6_+_86849488 0.541 ENSMUST00000089519.6
ENSMUST00000113668.1
Aak1

AP2 associated kinase 1

chr9_+_104566677 0.506 ENSMUST00000157006.1
Cpne4
copine IV
chr13_-_54611332 0.453 ENSMUST00000091609.4
Cltb
clathrin, light polypeptide (Lcb)
chr3_+_123267445 0.444 ENSMUST00000047923.7
Sec24d
Sec24 related gene family, member D (S. cerevisiae)
chr2_-_45110241 0.441 ENSMUST00000177302.1
Zeb2
zinc finger E-box binding homeobox 2
chr13_-_113663670 0.440 ENSMUST00000054650.4
Hspb3
heat shock protein 3
chr13_-_54611274 0.421 ENSMUST00000049575.7
Cltb
clathrin, light polypeptide (Lcb)
chr2_-_151632471 0.394 ENSMUST00000137936.1
ENSMUST00000146172.1
ENSMUST00000094456.3
ENSMUST00000148755.1
ENSMUST00000109875.1
ENSMUST00000028951.7
ENSMUST00000109877.3
Snph






syntaphilin






chr2_-_29253001 0.390 ENSMUST00000071201.4
Ntng2
netrin G2
chr10_-_64090265 0.370 ENSMUST00000105439.1
Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr2_+_156475844 0.363 ENSMUST00000103135.1
Epb4.1l1
erythrocyte protein band 4.1-like 1
chr10_-_64090241 0.360 ENSMUST00000133588.1
Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr11_-_100397740 0.359 ENSMUST00000001592.8
ENSMUST00000107403.1
Jup

junction plakoglobin

chr18_-_31317043 0.350 ENSMUST00000139924.1
ENSMUST00000153060.1
Rit2

Ras-like without CAAX 2

chr3_-_88503187 0.316 ENSMUST00000120377.1
Lmna
lamin A
chr2_+_156475803 0.306 ENSMUST00000029155.8
Epb4.1l1
erythrocyte protein band 4.1-like 1
chr15_-_102257306 0.298 ENSMUST00000135466.1
Rarg
retinoic acid receptor, gamma
chr15_-_102257449 0.291 ENSMUST00000043172.8
Rarg
retinoic acid receptor, gamma
chr14_+_79426454 0.285 ENSMUST00000061222.7
Kbtbd7
kelch repeat and BTB (POZ) domain containing 7
chr8_+_107293500 0.261 ENSMUST00000151114.1
ENSMUST00000075922.4
ENSMUST00000125721.1
Nfat5


nuclear factor of activated T cells 5


chr5_-_107875035 0.248 ENSMUST00000138111.1
ENSMUST00000112642.1
Evi5

ecotropic viral integration site 5

chr11_-_120630516 0.245 ENSMUST00000106181.1
Mafg
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian)
chr15_+_102503722 0.231 ENSMUST00000096145.4
Gm10337
predicted gene 10337
chr19_-_32210969 0.221 ENSMUST00000151289.1
Sgms1
sphingomyelin synthase 1
chr16_-_4880284 0.220 ENSMUST00000037843.6
Ubald1
UBA-like domain containing 1
chr19_+_5447692 0.217 ENSMUST00000025850.5
Fosl1
fos-like antigen 1
chr8_-_8639363 0.209 ENSMUST00000152698.1
Efnb2
ephrin B2
chr17_+_35841668 0.197 ENSMUST00000174124.1
Mdc1
mediator of DNA damage checkpoint 1
chr11_+_78188737 0.191 ENSMUST00000108322.2
Rab34
RAB34, member of RAS oncogene family
chr3_-_88503331 0.190 ENSMUST00000029699.6
Lmna
lamin A
chr10_+_26078255 0.188 ENSMUST00000041011.3
Gm9767
predicted gene 9767
chr8_+_36489191 0.186 ENSMUST00000171777.1
6430573F11Rik
RIKEN cDNA 6430573F11 gene
chr6_-_113934679 0.170 ENSMUST00000101044.2
Atp2b2
ATPase, Ca++ transporting, plasma membrane 2
chr9_-_119977250 0.149 ENSMUST00000035101.7
Csrnp1
cysteine-serine-rich nuclear protein 1
chr7_-_29505447 0.144 ENSMUST00000183096.1
ENSMUST00000085809.4
Sipa1l3

signal-induced proliferation-associated 1 like 3

chr13_+_30659999 0.138 ENSMUST00000091672.6
ENSMUST00000110310.1
ENSMUST00000095914.5
Dusp22


dual specificity phosphatase 22


chr5_-_5265224 0.133 ENSMUST00000115450.1
Cdk14
cyclin-dependent kinase 14
chr7_+_139834148 0.127 ENSMUST00000026548.7
Gpr123
G protein-coupled receptor 123
chr3_+_109573907 0.126 ENSMUST00000106576.2
Vav3
vav 3 oncogene
chr11_-_50210765 0.118 ENSMUST00000143379.1
ENSMUST00000015981.5
ENSMUST00000102774.4
Sqstm1


sequestosome 1


chr4_+_42158092 0.116 ENSMUST00000098122.2
Gm13306
predicted gene 13306
chr1_+_134560190 0.114 ENSMUST00000112198.1
ENSMUST00000112197.1
Kdm5b

lysine (K)-specific demethylase 5B

chr12_+_71015966 0.111 ENSMUST00000046305.5
Arid4a
AT rich interactive domain 4A (RBP1-like)
chr10_+_116143881 0.107 ENSMUST00000105271.2
Ptprr
protein tyrosine phosphatase, receptor type, R
chr11_+_78188422 0.106 ENSMUST00000002128.7
ENSMUST00000150941.1
Rab34

RAB34, member of RAS oncogene family

chr6_+_17463927 0.100 ENSMUST00000115442.1
Met
met proto-oncogene
chr11_+_78188806 0.099 ENSMUST00000056241.5
Rab34
RAB34, member of RAS oncogene family
chr2_+_164948219 0.096 ENSMUST00000017881.2
Mmp9
matrix metallopeptidase 9
chrX_-_75578188 0.092 ENSMUST00000033545.5
Rab39b
RAB39B, member RAS oncogene family
chr7_-_80401707 0.091 ENSMUST00000120753.1
Furin
furin (paired basic amino acid cleaving enzyme)
chr7_+_126776939 0.088 ENSMUST00000038614.5
ENSMUST00000170882.1
ENSMUST00000106359.1
ENSMUST00000106357.1
ENSMUST00000145762.1
ENSMUST00000132643.1
ENSMUST00000106356.1
Ypel3






yippee-like 3 (Drosophila)






chr18_-_43477764 0.080 ENSMUST00000057110.9
Eif3j2
eukaryotic translation initiation factor 3, subunit J2
chr7_+_30413744 0.079 ENSMUST00000032800.9
Tyrobp
TYRO protein tyrosine kinase binding protein
chrX_+_73675500 0.067 ENSMUST00000171398.1
Slc6a8
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chr7_-_100547620 0.059 ENSMUST00000064334.2
D630004N19Rik
RIKEN cDNA D630004N19 gene
chr9_+_114978507 0.054 ENSMUST00000183104.1
Osbpl10
oxysterol binding protein-like 10
chr9_+_122888471 0.048 ENSMUST00000063980.6
Zkscan7
zinc finger with KRAB and SCAN domains 7
chr18_+_40258361 0.034 ENSMUST00000091927.4
Kctd16
potassium channel tetramerisation domain containing 16
chr8_+_4226827 0.033 ENSMUST00000053035.6
Lrrc8e
leucine rich repeat containing 8 family, member E
chr9_-_109059216 0.031 ENSMUST00000112053.1
Trex1
three prime repair exonuclease 1
chr12_+_83632208 0.027 ENSMUST00000048155.9
ENSMUST00000182618.1
ENSMUST00000183154.1
ENSMUST00000182036.1
ENSMUST00000182347.1
Rbm25




RNA binding motif protein 25




chr6_-_129533267 0.019 ENSMUST00000181594.1
1700101I11Rik
RIKEN cDNA 1700101I11 gene
chr9_-_109059711 0.019 ENSMUST00000061973.4
Trex1
three prime repair exonuclease 1
chr5_-_62766153 0.012 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
0.1 0.4 GO:0002159 desmosome assembly(GO:0002159)
0.1 0.5 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.1 0.4 GO:1905169 protein localization to phagocytic vesicle(GO:1905161) regulation of protein localization to phagocytic vesicle(GO:1905169) positive regulation of protein localization to phagocytic vesicle(GO:1905171)
0.1 0.4 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.1 0.3 GO:0032489 regulation of Cdc42 protein signal transduction(GO:0032489)
0.0 0.7 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.0 0.4 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.2 GO:0007296 vitellogenesis(GO:0007296)
0.0 0.2 GO:0048840 otolith development(GO:0048840)
0.0 0.1 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.0 0.2 GO:1903847 regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.0 0.2 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.6 GO:0033198 response to ATP(GO:0033198)
0.0 0.1 GO:0090472 dibasic protein processing(GO:0090472)
0.0 1.1 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 0.5 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.0 0.1 GO:0035937 estrogen secretion(GO:0035937) estradiol secretion(GO:0035938) regulation of estrogen secretion(GO:2000861) regulation of estradiol secretion(GO:2000864)
0.0 0.1 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.0 0.1 GO:0002710 negative regulation of T cell mediated immunity(GO:0002710)
0.0 0.1 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.0 0.1 GO:0034773 histone H4-K20 trimethylation(GO:0034773) establishment of Sertoli cell barrier(GO:0097368)
0.0 0.1 GO:2000774 positive regulation of cellular senescence(GO:2000774)
0.0 0.2 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.0 0.1 GO:2001204 regulation of osteoclast development(GO:2001204)
0.0 0.9 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
0.0 0.6 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 0.3 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.0 0.1 GO:0061635 regulation of protein complex stability(GO:0061635)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0071439 clathrin complex(GO:0071439)
0.1 0.3 GO:0097447 dendritic tree(GO:0097447)
0.1 0.9 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.1 1.1 GO:0042581 specific granule(GO:0042581)
0.1 0.5 GO:0005638 lamin filament(GO:0005638)
0.1 0.6 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.1 GO:0044753 amphisome(GO:0044753)
0.0 0.6 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.4 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.0 0.4 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.1 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 0.1 GO:0061689 tricellular tight junction(GO:0061689)
0.0 0.2 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.1 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 1.4 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.4 GO:0046658 anchored component of plasma membrane(GO:0046658)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1 0.9 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.1 0.6 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.2 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 0.5 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.0 0.2 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.0 0.6 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.4 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.1 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.0 0.1 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.0 0.3 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.4 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 0.5 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.1 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 0.4 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.0 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.0 0.9 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 0.4 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.2 GO:0005388 calcium-transporting ATPase activity(GO:0005388)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.9 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.6 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.3 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.4 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 0.9 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.0 0.4 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.3 REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 0.6 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.2 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.2 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions