Motif ID: Hsf1

Z-value: 0.629


Transcription factors associated with Hsf1:

Gene SymbolEntrez IDGene Name
Hsf1 ENSMUSG00000022556.9 Hsf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hsf1mm10_v2_chr15_+_76477404_76477461-0.503.3e-02Click!


Activity profile for motif Hsf1.

activity profile for motif Hsf1


Sorted Z-values histogram for motif Hsf1

Sorted Z-values for motif Hsf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hsf1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_-_48667508 3.049 ENSMUST00000144465.1
ENSMUST00000133479.1
ENSMUST00000119070.1
ENSMUST00000152018.1
Otx2



orthodenticle homolog 2 (Drosophila)



chr11_-_116335384 1.811 ENSMUST00000036215.7
Foxj1
forkhead box J1
chr2_+_157560078 1.467 ENSMUST00000153739.2
ENSMUST00000173595.1
ENSMUST00000109526.1
ENSMUST00000173839.1
ENSMUST00000173041.1
ENSMUST00000173793.1
ENSMUST00000172487.1
ENSMUST00000088484.5
Nnat







neuronatin







chr9_-_103480328 1.417 ENSMUST00000124310.2
Bfsp2
beaded filament structural protein 2, phakinin
chr7_-_99353104 1.405 ENSMUST00000169437.1
ENSMUST00000094154.4
Serpinh1

serine (or cysteine) peptidase inhibitor, clade H, member 1

chr6_-_128438673 1.347 ENSMUST00000032508.4
Fkbp4
FK506 binding protein 4
chr7_-_70366735 1.304 ENSMUST00000089565.5
Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr11_+_82911253 1.229 ENSMUST00000164945.1
ENSMUST00000018989.7
Unc45b

unc-45 homolog B (C. elegans)

chr8_-_45382198 1.124 ENSMUST00000093526.6
Fam149a
family with sequence similarity 149, member A
chr6_+_128438757 0.994 ENSMUST00000144745.1
Gm10069
predicted gene 10069
chr12_-_110696332 0.988 ENSMUST00000094361.4
Hsp90aa1
heat shock protein 90, alpha (cytosolic), class A member 1
chr19_-_7039987 0.988 ENSMUST00000025918.7
Stip1
stress-induced phosphoprotein 1
chr9_+_40801235 0.980 ENSMUST00000117870.1
ENSMUST00000117557.1
Hspa8

heat shock protein 8

chr5_-_149636164 0.844 ENSMUST00000076410.4
Hsph1
heat shock 105kDa/110kDa protein 1
chr11_-_116843449 0.831 ENSMUST00000047616.3
Jmjd6
jumonji domain containing 6
chr10_+_80826656 0.813 ENSMUST00000060987.8
ENSMUST00000177850.1
ENSMUST00000180036.1
ENSMUST00000179172.1
Oaz1



ornithine decarboxylase antizyme 1



chr5_-_149636331 0.808 ENSMUST00000074846.7
ENSMUST00000110498.1
ENSMUST00000127977.1
ENSMUST00000132412.1
Hsph1



heat shock 105kDa/110kDa protein 1



chr5_+_30281377 0.752 ENSMUST00000101448.3
Drc1
dynein regulatory complex subunit 1
chr4_+_40722461 0.714 ENSMUST00000030118.3
Dnaja1
DnaJ (Hsp40) homolog, subfamily A, member 1
chr1_+_91250482 0.680 ENSMUST00000171112.1
Ube2f
ubiquitin-conjugating enzyme E2F (putative)
chr5_+_66676098 0.654 ENSMUST00000031131.9
Uchl1
ubiquitin carboxy-terminal hydrolase L1
chr2_+_163694015 0.652 ENSMUST00000109400.2
Pkig
protein kinase inhibitor, gamma
chr15_-_31601786 0.631 ENSMUST00000022842.8
Cct5
chaperonin containing Tcp1, subunit 5 (epsilon)
chr11_+_22990519 0.622 ENSMUST00000173867.1
ENSMUST00000020562.4
Cct4

chaperonin containing Tcp1, subunit 4 (delta)

chr12_-_110696289 0.613 ENSMUST00000021698.6
Hsp90aa1
heat shock protein 90, alpha (cytosolic), class A member 1
chr12_+_117843873 0.592 ENSMUST00000176735.1
ENSMUST00000177339.1
Cdca7l

cell division cycle associated 7 like

chr18_+_6332587 0.580 ENSMUST00000097682.2
Rpl27-ps3
ribosomal protein L27, pseudogene 3
chr10_-_86705485 0.548 ENSMUST00000020238.7
Hsp90b1
heat shock protein 90, beta (Grp94), member 1
chr5_+_129020069 0.546 ENSMUST00000031383.7
ENSMUST00000111343.1
Ran

RAN, member RAS oncogene family

chr4_-_136892867 0.528 ENSMUST00000046332.5
C1qc
complement component 1, q subcomponent, C chain
chr2_+_120463566 0.521 ENSMUST00000028749.7
ENSMUST00000110721.1
Capn3

calpain 3

chr15_-_31601506 0.521 ENSMUST00000161266.1
Cct5
chaperonin containing Tcp1, subunit 5 (epsilon)
chr11_+_6560183 0.519 ENSMUST00000109722.2
Ccm2
cerebral cavernous malformation 2
chr4_-_133545906 0.519 ENSMUST00000030665.6
Nudc
nuclear distribution gene C homolog (Aspergillus)
chr16_-_87495823 0.508 ENSMUST00000176041.1
ENSMUST00000026704.7
Cct8

chaperonin containing Tcp1, subunit 8 (theta)

chr16_-_87495704 0.507 ENSMUST00000176750.1
ENSMUST00000175977.1
Cct8

chaperonin containing Tcp1, subunit 8 (theta)

chr15_+_75704280 0.505 ENSMUST00000121137.1
ENSMUST00000023244.5
Rhpn1

rhophilin, Rho GTPase binding protein 1

chr1_+_57774842 0.481 ENSMUST00000167085.1
Spats2l
spermatogenesis associated, serine-rich 2-like
chr2_+_25180737 0.479 ENSMUST00000104999.2
Nrarp
Notch-regulated ankyrin repeat protein
chr16_-_22265950 0.462 ENSMUST00000161286.1
Tra2b
transformer 2 beta homolog (Drosophila)
chr1_+_55088132 0.453 ENSMUST00000075242.6
Hspe1
heat shock protein 1 (chaperonin 10)
chr14_-_65833963 0.451 ENSMUST00000022613.9
Esco2
establishment of cohesion 1 homolog 2 (S. cerevisiae)
chr17_+_47593444 0.448 ENSMUST00000182209.1
Ccnd3
cyclin D3
chrX_+_42149288 0.447 ENSMUST00000115073.2
ENSMUST00000115072.1
Stag2

stromal antigen 2

chr7_-_89941196 0.444 ENSMUST00000117354.1
l7Rn6
lethal, Chr 7, Rinchik 6
chr18_-_10706688 0.443 ENSMUST00000002549.7
ENSMUST00000117726.1
ENSMUST00000117828.1
Abhd3


abhydrolase domain containing 3


chr17_+_31564749 0.435 ENSMUST00000175806.1
ENSMUST00000097352.3
Pknox1

Pbx/knotted 1 homeobox

chrX_+_42149534 0.434 ENSMUST00000127618.1
Stag2
stromal antigen 2
chr7_-_110862944 0.433 ENSMUST00000033050.3
Lyve1
lymphatic vessel endothelial hyaluronan receptor 1
chr6_-_51469869 0.406 ENSMUST00000114459.1
ENSMUST00000069949.6
Hnrnpa2b1

heterogeneous nuclear ribonucleoprotein A2/B1

chr3_+_79591356 0.399 ENSMUST00000029382.7
Ppid
peptidylprolyl isomerase D (cyclophilin D)
chr1_-_55088024 0.391 ENSMUST00000027123.8
Hspd1
heat shock protein 1 (chaperonin)
chr15_+_87625214 0.367 ENSMUST00000068088.6
Fam19a5
family with sequence similarity 19, member A5
chr5_+_129787390 0.364 ENSMUST00000031402.8
Cct6a
chaperonin containing Tcp1, subunit 6a (zeta)
chr6_-_136941887 0.355 ENSMUST00000111891.1
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr7_-_89941084 0.350 ENSMUST00000075010.4
ENSMUST00000153470.1
l7Rn6

lethal, Chr 7, Rinchik 6

chrX_-_140956675 0.345 ENSMUST00000033805.8
ENSMUST00000112978.1
Psmd10

proteasome (prosome, macropain) 26S subunit, non-ATPase, 10

chr11_-_48946148 0.344 ENSMUST00000104958.1
Psme2b
protease (prosome, macropain) activator subunit 2B
chr7_+_49759100 0.341 ENSMUST00000085272.5
Htatip2
HIV-1 tat interactive protein 2, homolog (human)
chr4_+_40722912 0.333 ENSMUST00000164233.1
ENSMUST00000137246.1
ENSMUST00000125442.1
Dnaja1


DnaJ (Hsp40) homolog, subfamily A, member 1


chr17_+_70929006 0.331 ENSMUST00000092011.6
Gm16519
predicted gene, 16519
chr15_+_31602106 0.329 ENSMUST00000042702.6
Fam173b
family with sequence similarity 173, member B
chr5_-_129787175 0.329 ENSMUST00000031399.6
Psph
phosphoserine phosphatase
chr11_+_49609263 0.308 ENSMUST00000020617.2
Flt4
FMS-like tyrosine kinase 4
chr5_+_135887905 0.305 ENSMUST00000005077.6
Hspb1
heat shock protein 1
chr6_-_51469836 0.292 ENSMUST00000090002.7
Hnrnpa2b1
heterogeneous nuclear ribonucleoprotein A2/B1
chr12_-_54695885 0.289 ENSMUST00000067272.8
Eapp
E2F-associated phosphoprotein
chr12_-_54695813 0.282 ENSMUST00000110713.3
Eapp
E2F-associated phosphoprotein
chr11_+_83662579 0.281 ENSMUST00000019074.3
Ccl4
chemokine (C-C motif) ligand 4
chr1_-_119053619 0.278 ENSMUST00000062483.8
Gli2
GLI-Kruppel family member GLI2
chr2_-_92460449 0.278 ENSMUST00000125276.1
Slc35c1
solute carrier family 35, member C1
chr10_+_127642975 0.271 ENSMUST00000092074.5
ENSMUST00000120279.1
Stat6

signal transducer and activator of transcription 6

chr6_+_51470339 0.254 ENSMUST00000094623.3
Cbx3
chromobox 3
chr17_-_50094277 0.243 ENSMUST00000113195.1
Rftn1
raftlin lipid raft linker 1
chr7_+_92561141 0.237 ENSMUST00000032842.6
ENSMUST00000085017.4
Ccdc90b

coiled-coil domain containing 90B

chr1_+_57774600 0.233 ENSMUST00000167971.1
ENSMUST00000170139.1
ENSMUST00000171699.1
ENSMUST00000164302.1
Spats2l



spermatogenesis associated, serine-rich 2-like



chr5_+_149184555 0.232 ENSMUST00000050472.9
Uspl1
ubiquitin specific peptidase like 1
chr17_+_35470083 0.230 ENSMUST00000174525.1
ENSMUST00000068291.6
H2-Q10

histocompatibility 2, Q region locus 10

chr17_+_47593516 0.229 ENSMUST00000182874.1
Ccnd3
cyclin D3
chr5_+_149184648 0.224 ENSMUST00000122160.1
ENSMUST00000100410.3
ENSMUST00000119685.1
Uspl1


ubiquitin specific peptidase like 1


chr12_+_88083697 0.219 ENSMUST00000177720.1
Gm16368
predicted pseudogene 16368
chr15_-_81400043 0.216 ENSMUST00000172107.1
ENSMUST00000169204.1
ENSMUST00000163382.1
St13


suppression of tumorigenicity 13


chr12_+_75308308 0.208 ENSMUST00000118602.1
ENSMUST00000118966.1
ENSMUST00000055390.5
Rhoj


ras homolog gene family, member J


chr15_-_81399594 0.202 ENSMUST00000023039.8
St13
suppression of tumorigenicity 13
chr5_+_135887988 0.194 ENSMUST00000111155.1
Hspb1
heat shock protein 1
chr5_-_123749371 0.190 ENSMUST00000182955.1
ENSMUST00000182489.1
ENSMUST00000050827.7
Rsrc2


arginine/serine-rich coiled-coil 2


chr11_+_100619217 0.186 ENSMUST00000107376.1
Nkiras2
NFKB inhibitor interacting Ras-like protein 2
chr11_-_5099036 0.181 ENSMUST00000102930.3
Ewsr1
Ewing sarcoma breakpoint region 1
chr6_+_86527312 0.177 ENSMUST00000181928.1
1600020E01Rik
RIKEN cDNA 1600020E01 gene
chr10_-_61383523 0.177 ENSMUST00000020289.8
Pald1
phosphatase domain containing, paladin 1
chr12_-_54695829 0.176 ENSMUST00000162106.1
ENSMUST00000160085.1
ENSMUST00000161592.1
ENSMUST00000163433.1
Eapp



E2F-associated phosphoprotein



chr3_-_106547564 0.174 ENSMUST00000121231.1
ENSMUST00000141525.1
Cept1

choline/ethanolaminephosphotransferase 1

chr14_+_34375504 0.172 ENSMUST00000111908.1
Mmrn2
multimerin 2
chr19_+_6363896 0.168 ENSMUST00000113487.1
Sf1
splicing factor 1
chr5_+_29735940 0.154 ENSMUST00000114839.1
Dnajb6
DnaJ (Hsp40) homolog, subfamily B, member 6
chr18_-_36766198 0.142 ENSMUST00000061522.7
Dnd1
dead end homolog 1 (zebrafish)
chr13_-_111490111 0.142 ENSMUST00000047627.7
Gpbp1
GC-rich promoter binding protein 1
chr9_+_18292267 0.138 ENSMUST00000001825.7
Chordc1
cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1
chr11_+_116843278 0.128 ENSMUST00000106370.3
Mettl23
methyltransferase like 23
chr11_-_5099223 0.119 ENSMUST00000079949.6
Ewsr1
Ewing sarcoma breakpoint region 1
chr5_+_149184678 0.118 ENSMUST00000139474.1
ENSMUST00000117878.1
Uspl1

ubiquitin specific peptidase like 1

chr5_+_29735688 0.118 ENSMUST00000008733.8
Dnajb6
DnaJ (Hsp40) homolog, subfamily B, member 6
chr14_-_63193541 0.114 ENSMUST00000038229.4
Neil2
nei like 2 (E. coli)
chr8_-_109693235 0.113 ENSMUST00000034164.4
Ist1
increased sodium tolerance 1 homolog (yeast)
chr7_+_119895836 0.107 ENSMUST00000106518.1
ENSMUST00000054440.3
Lyrm1

LYR motif containing 1

chr19_+_6363671 0.091 ENSMUST00000131252.1
Sf1
splicing factor 1
chrX_+_71663665 0.085 ENSMUST00000070449.5
Gpr50
G-protein-coupled receptor 50
chr8_+_36489191 0.084 ENSMUST00000171777.1
6430573F11Rik
RIKEN cDNA 6430573F11 gene
chr7_-_119895446 0.082 ENSMUST00000098080.2
Dcun1d3
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr4_+_152178126 0.066 ENSMUST00000075363.3
Acot7
acyl-CoA thioesterase 7
chr5_-_123749393 0.053 ENSMUST00000057795.5
ENSMUST00000111515.1
ENSMUST00000182309.1
Rsrc2


arginine/serine-rich coiled-coil 2


chr2_+_72297895 0.046 ENSMUST00000144111.1
Zak
sterile alpha motif and leucine zipper containing kinase AZK
chr19_+_6363719 0.046 ENSMUST00000113489.1
ENSMUST00000113488.1
Sf1

splicing factor 1

chr11_-_5099053 0.045 ENSMUST00000093365.5
ENSMUST00000073308.4
Ewsr1

Ewing sarcoma breakpoint region 1

chr5_-_92675253 0.044 ENSMUST00000151180.1
ENSMUST00000150359.1
Ccdc158

coiled-coil domain containing 158

chr18_+_77065195 0.021 ENSMUST00000114777.2
Pias2
protein inhibitor of activated STAT 2
chr3_-_89402650 0.017 ENSMUST00000168325.1
ENSMUST00000057431.5
Lenep

lens epithelial protein

chr9_+_22411515 0.014 ENSMUST00000058868.7
9530077C05Rik
RIKEN cDNA 9530077C05 gene
chr17_-_15041457 0.012 ENSMUST00000097398.4
ENSMUST00000040746.6
ENSMUST00000097400.4
Tcte3

Gm3448
t-complex-associated testis expressed 3

predicted gene 3448

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.0 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.5 1.8 GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002924) negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.4 1.7 GO:0045343 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343) positive regulation of MHC class I biosynthetic process(GO:0045345) positive regulation of NK T cell activation(GO:0051135)
0.3 1.0 GO:1903054 protein targeting to vacuole involved in autophagy(GO:0071211) lysosomal membrane organization(GO:0097212) negative regulation of extracellular matrix organization(GO:1903054) positive regulation of protein folding(GO:1903334)
0.3 3.2 GO:1990173 protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) protein localization to nucleoplasm(GO:1990173)
0.3 1.6 GO:0045583 regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585)
0.3 1.3 GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.2 0.8 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.2 1.4 GO:0003433 chondrocyte development involved in endochondral bone morphogenesis(GO:0003433)
0.2 0.5 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
0.2 0.7 GO:0007412 axon target recognition(GO:0007412)
0.1 0.6 GO:0030576 Cajal body organization(GO:0030576)
0.1 0.8 GO:0043654 recognition of apoptotic cell(GO:0043654)
0.1 0.4 GO:0071492 cellular response to UV-A(GO:0071492)
0.1 1.0 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.1 0.3 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.1 0.3 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.1 1.4 GO:0070307 lens fiber cell development(GO:0070307)
0.1 0.7 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)
0.1 0.3 GO:2000501 natural killer cell chemotaxis(GO:0035747) regulation of natural killer cell chemotaxis(GO:2000501)
0.1 0.3 GO:0035771 interleukin-4-mediated signaling pathway(GO:0035771)
0.1 0.5 GO:0034421 post-translational protein acetylation(GO:0034421)
0.1 0.9 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.1 0.3 GO:0002842 positive regulation of T cell mediated immune response to tumor cell(GO:0002842) protein import into mitochondrial intermembrane space(GO:0045041)
0.1 0.5 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
0.1 0.5 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
0.1 0.3 GO:0060032 notochord regression(GO:0060032)
0.1 0.5 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.1 0.3 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.1 1.3 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.1 0.4 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.1 0.7 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.1 0.7 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.1 0.4 GO:0061084 negative regulation of protein refolding(GO:0061084)
0.0 0.5 GO:0071318 cellular response to ATP(GO:0071318)
0.0 0.2 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.0 0.5 GO:0060837 blood vessel endothelial cell differentiation(GO:0060837)
0.0 0.5 GO:0014807 regulation of somitogenesis(GO:0014807)
0.0 0.4 GO:0006027 glycosaminoglycan catabolic process(GO:0006027)
0.0 0.7 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.0 0.1 GO:0009838 abscission(GO:0009838)
0.0 0.8 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.0 0.5 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0 0.7 GO:0045116 protein neddylation(GO:0045116)
0.0 0.3 GO:0030259 lipid glycosylation(GO:0030259)
0.0 1.4 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.0 0.5 GO:0021796 cerebral cortex regionalization(GO:0021796) embryonic brain development(GO:1990403)
0.0 0.3 GO:0090037 positive regulation of protein kinase C signaling(GO:0090037)
0.0 0.3 GO:0030238 male sex determination(GO:0030238)
0.0 0.2 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0 1.5 GO:0032024 positive regulation of insulin secretion(GO:0032024)
0.0 0.6 GO:0046470 phosphatidylcholine metabolic process(GO:0046470)
0.0 0.1 GO:1900533 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
0.0 0.2 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.6 GO:0097226 sperm mitochondrial sheath(GO:0097226)
0.3 3.2 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.2 1.0 GO:0043202 lysosomal lumen(GO:0043202)
0.2 0.5 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.1 0.7 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.1 0.7 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.3 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 0.5 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.2 GO:0097512 cardiac myofibril(GO:0097512)
0.0 0.3 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 1.3 GO:0044295 axonal growth cone(GO:0044295)
0.0 1.5 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 1.4 GO:0005882 intermediate filament(GO:0005882)
0.0 0.3 GO:0097542 ciliary tip(GO:0097542)
0.0 0.2 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.6 GO:0015030 Cajal body(GO:0015030)
0.0 0.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.5 GO:0005637 nuclear inner membrane(GO:0005637)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0031686 A1 adenosine receptor binding(GO:0031686)
0.3 1.3 GO:0032767 copper-dependent protein binding(GO:0032767)
0.2 1.4 GO:0002135 CTP binding(GO:0002135)
0.2 0.8 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.2 0.6 GO:0070140 isopeptidase activity(GO:0070122) ubiquitin-like protein-specific isopeptidase activity(GO:0070138) SUMO-specific isopeptidase activity(GO:0070140)
0.2 1.7 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.2 0.8 GO:0070815 peptidyl-lysine 5-dioxygenase activity(GO:0070815)
0.2 0.7 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.1 1.0 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.1 0.4 GO:0052740 phosphatidylserine 1-acylhydrolase activity(GO:0052739) 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.1 0.4 GO:0032564 dATP binding(GO:0032564)
0.1 1.1 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 4.0 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 0.7 GO:0001069 regulatory region RNA binding(GO:0001069)
0.1 0.3 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.1 1.3 GO:0001972 retinoic acid binding(GO:0001972)
0.1 0.5 GO:0070883 pre-miRNA binding(GO:0070883)
0.1 0.7 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.1 0.3 GO:0045131 pre-mRNA branch point binding(GO:0045131)
0.1 0.5 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 0.5 GO:0046790 virion binding(GO:0046790)
0.1 0.5 GO:0031432 titin binding(GO:0031432)
0.1 0.4 GO:0016018 cyclosporin A binding(GO:0016018)
0.1 0.4 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 0.3 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.7 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 2.2 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.2 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.0 0.3 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.0 1.4 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 1.0 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 0.1 GO:0008502 melatonin receptor activity(GO:0008502)
0.0 0.4 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 3.0 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 0.3 GO:1990226 histone methyltransferase binding(GO:1990226)
0.0 0.2 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.0 0.5 GO:0070717 poly-purine tract binding(GO:0070717)
0.0 0.7 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 0.1 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 1.4 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 0.3 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 1.3 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.4 PID_PLK1_PATHWAY PLK1 signaling events
0.0 2.0 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 0.5 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.0 1.0 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 0.7 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 1.3 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 0.5 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 0.6 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 0.5 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 0.3 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.2 REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.1 0.5 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 1.6 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.1 0.5 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.4 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 1.0 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.5 REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.0 0.3 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.5 REACTOME_MICRORNA_MIRNA_BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.0 1.4 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 2.0 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.2 REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0 0.2 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.0 1.4 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.3 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.3 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines