Motif ID: Vsx1_Uncx_Prrx2_Shox2_Noto
Z-value: 0.980





Transcription factors associated with Vsx1_Uncx_Prrx2_Shox2_Noto:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Noto | ENSMUSG00000068302.7 | Noto |
Prrx2 | ENSMUSG00000039476.7 | Prrx2 |
Shox2 | ENSMUSG00000027833.10 | Shox2 |
Uncx | ENSMUSG00000029546.11 | Uncx |
Vsx1 | ENSMUSG00000033080.8 | Vsx1 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Uncx | mm10_v2_chr5_+_139543889_139543904 | 0.81 | 5.5e-05 | Click! |
Prrx2 | mm10_v2_chr2_+_30834972_30834972 | 0.48 | 4.6e-02 | Click! |
Shox2 | mm10_v2_chr3_-_66981279_66981318 | 0.12 | 6.2e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
3.4 | 13.5 | GO:0046552 | eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552) |
1.6 | 4.8 | GO:0061357 | Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) positive regulation of Wnt protein secretion(GO:0061357) |
1.6 | 4.7 | GO:0035880 | embryonic nail plate morphogenesis(GO:0035880) positive regulation of catagen(GO:0051795) frontal suture morphogenesis(GO:0060364) |
1.5 | 12.2 | GO:0035726 | common myeloid progenitor cell proliferation(GO:0035726) |
1.5 | 4.5 | GO:0002302 | CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302) |
1.2 | 7.1 | GO:0006570 | tyrosine metabolic process(GO:0006570) |
1.1 | 6.9 | GO:0060648 | mammary gland bud morphogenesis(GO:0060648) |
0.8 | 6.7 | GO:0003150 | muscular septum morphogenesis(GO:0003150) |
0.8 | 13.8 | GO:0001833 | inner cell mass cell proliferation(GO:0001833) |
0.8 | 2.3 | GO:0030916 | otic vesicle formation(GO:0030916) |
0.7 | 2.8 | GO:1904565 | response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566) |
0.5 | 2.5 | GO:2000987 | positive regulation of fear response(GO:1903367) positive regulation of behavioral fear response(GO:2000987) |
0.5 | 1.4 | GO:0035934 | corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852) |
0.4 | 4.8 | GO:0021521 | ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573) |
0.4 | 1.2 | GO:0060166 | olfactory pit development(GO:0060166) |
0.4 | 3.5 | GO:0010587 | miRNA catabolic process(GO:0010587) |
0.4 | 2.3 | GO:0045218 | zonula adherens maintenance(GO:0045218) |
0.4 | 1.5 | GO:0061743 | motor learning(GO:0061743) |
0.4 | 1.9 | GO:0001661 | conditioned taste aversion(GO:0001661) amygdala development(GO:0021764) |
0.4 | 3.0 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
0.4 | 0.7 | GO:0042320 | regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) |
0.4 | 1.1 | GO:0003162 | atrioventricular node development(GO:0003162) |
0.3 | 6.6 | GO:0071803 | keratinocyte development(GO:0003334) positive regulation of podosome assembly(GO:0071803) |
0.3 | 2.7 | GO:0009249 | protein lipoylation(GO:0009249) |
0.3 | 4.3 | GO:0021796 | cerebral cortex regionalization(GO:0021796) |
0.3 | 1.3 | GO:0035553 | oxidative single-stranded RNA demethylation(GO:0035553) |
0.3 | 1.0 | GO:0060743 | epithelial cell maturation involved in prostate gland development(GO:0060743) alveolar secondary septum development(GO:0061144) |
0.3 | 0.6 | GO:2000974 | negative regulation of pro-B cell differentiation(GO:2000974) |
0.3 | 0.9 | GO:0036233 | glycine import(GO:0036233) |
0.3 | 0.6 | GO:1902256 | apoptotic process involved in outflow tract morphogenesis(GO:0003275) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256) |
0.3 | 0.9 | GO:2001013 | cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204) epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013) |
0.3 | 0.5 | GO:1904956 | regulation of midbrain dopaminergic neuron differentiation(GO:1904956) |
0.3 | 0.8 | GO:0016554 | cytidine to uridine editing(GO:0016554) |
0.3 | 3.3 | GO:0034219 | carbohydrate transmembrane transport(GO:0034219) |
0.2 | 1.7 | GO:0032782 | bile acid secretion(GO:0032782) |
0.2 | 1.4 | GO:0051798 | positive regulation of hair follicle development(GO:0051798) |
0.2 | 3.1 | GO:0007213 | G-protein coupled acetylcholine receptor signaling pathway(GO:0007213) regulation of dopamine receptor signaling pathway(GO:0060159) |
0.2 | 0.9 | GO:0018065 | protein-cofactor linkage(GO:0018065) |
0.2 | 4.2 | GO:0007530 | sex determination(GO:0007530) |
0.2 | 1.0 | GO:1904936 | cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936) |
0.2 | 1.0 | GO:0052695 | cellular glucuronidation(GO:0052695) |
0.2 | 0.7 | GO:0015889 | cobalamin transport(GO:0015889) |
0.2 | 2.7 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
0.2 | 1.2 | GO:0021978 | telencephalon regionalization(GO:0021978) |
0.2 | 0.5 | GO:0045113 | regulation of integrin biosynthetic process(GO:0045113) |
0.2 | 0.5 | GO:1905000 | regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000) |
0.2 | 0.5 | GO:0090526 | regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526) |
0.2 | 0.3 | GO:0090365 | regulation of mRNA modification(GO:0090365) |
0.1 | 0.7 | GO:0006564 | L-serine biosynthetic process(GO:0006564) |
0.1 | 3.8 | GO:0009954 | proximal/distal pattern formation(GO:0009954) |
0.1 | 1.6 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
0.1 | 0.8 | GO:0043415 | positive regulation of skeletal muscle tissue regeneration(GO:0043415) |
0.1 | 0.4 | GO:0030210 | heparin biosynthetic process(GO:0030210) Tie signaling pathway(GO:0048014) |
0.1 | 0.5 | GO:0001550 | ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) |
0.1 | 0.6 | GO:0014816 | skeletal muscle satellite cell differentiation(GO:0014816) |
0.1 | 0.3 | GO:0050748 | negative regulation of receptor biosynthetic process(GO:0010871) transforming growth factor-beta secretion(GO:0038044) negative regulation of lipoprotein metabolic process(GO:0050748) |
0.1 | 0.2 | GO:0097155 | fasciculation of sensory neuron axon(GO:0097155) |
0.1 | 0.9 | GO:0032049 | cardiolipin biosynthetic process(GO:0032049) |
0.1 | 0.3 | GO:0009826 | unidimensional cell growth(GO:0009826) susceptibility to natural killer cell mediated cytotoxicity(GO:0042271) |
0.1 | 0.5 | GO:0038032 | termination of G-protein coupled receptor signaling pathway(GO:0038032) |
0.1 | 1.2 | GO:0006488 | dolichol-linked oligosaccharide biosynthetic process(GO:0006488) |
0.1 | 0.3 | GO:0090425 | hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979) |
0.1 | 0.3 | GO:0060023 | soft palate development(GO:0060023) |
0.1 | 0.3 | GO:0060729 | intestinal epithelial structure maintenance(GO:0060729) |
0.1 | 3.8 | GO:0006270 | DNA replication initiation(GO:0006270) |
0.1 | 0.3 | GO:0003221 | right ventricular cardiac muscle tissue morphogenesis(GO:0003221) |
0.1 | 1.1 | GO:0060539 | diaphragm development(GO:0060539) |
0.1 | 1.0 | GO:2000741 | positive regulation of mesenchymal stem cell differentiation(GO:2000741) |
0.1 | 0.5 | GO:0015692 | vanadium ion transport(GO:0015676) lead ion transport(GO:0015692) |
0.1 | 10.1 | GO:0048706 | embryonic skeletal system development(GO:0048706) |
0.1 | 0.2 | GO:0042536 | negative regulation of tumor necrosis factor biosynthetic process(GO:0042536) |
0.1 | 1.2 | GO:0030497 | fatty acid elongation(GO:0030497) |
0.1 | 2.2 | GO:0033194 | response to hydroperoxide(GO:0033194) |
0.1 | 0.5 | GO:0002326 | B cell lineage commitment(GO:0002326) |
0.1 | 0.6 | GO:0006348 | chromatin silencing at telomere(GO:0006348) |
0.1 | 2.7 | GO:0097352 | autophagosome maturation(GO:0097352) |
0.1 | 0.8 | GO:0033148 | positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148) |
0.1 | 0.8 | GO:0043922 | negative regulation by host of viral transcription(GO:0043922) |
0.1 | 0.2 | GO:0010360 | negative regulation of anion channel activity(GO:0010360) |
0.1 | 0.3 | GO:1900740 | regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740) |
0.1 | 0.2 | GO:0090324 | negative regulation of oxidative phosphorylation(GO:0090324) |
0.1 | 3.1 | GO:0051693 | actin filament capping(GO:0051693) |
0.1 | 1.1 | GO:0050860 | negative regulation of T cell receptor signaling pathway(GO:0050860) |
0.1 | 3.9 | GO:0042773 | ATP synthesis coupled electron transport(GO:0042773) |
0.1 | 2.0 | GO:0018345 | protein palmitoylation(GO:0018345) |
0.1 | 1.1 | GO:0006337 | nucleosome disassembly(GO:0006337) |
0.1 | 1.9 | GO:0034723 | DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723) |
0.1 | 0.2 | GO:0048245 | eosinophil chemotaxis(GO:0048245) |
0.1 | 1.0 | GO:0045332 | phospholipid translocation(GO:0045332) |
0.1 | 0.5 | GO:0035372 | protein localization to microtubule(GO:0035372) |
0.1 | 2.8 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
0.1 | 0.9 | GO:0006107 | oxaloacetate metabolic process(GO:0006107) |
0.1 | 0.8 | GO:1903504 | regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504) |
0.1 | 1.1 | GO:1901020 | negative regulation of calcium ion transmembrane transporter activity(GO:1901020) |
0.1 | 0.4 | GO:0006003 | fructose 2,6-bisphosphate metabolic process(GO:0006003) |
0.1 | 0.3 | GO:0016078 | tRNA catabolic process(GO:0016078) |
0.0 | 0.3 | GO:0010908 | regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) |
0.0 | 0.4 | GO:0019243 | methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727) |
0.0 | 0.6 | GO:0060307 | regulation of ventricular cardiac muscle cell membrane repolarization(GO:0060307) |
0.0 | 0.1 | GO:1904245 | regulation of polynucleotide adenylyltransferase activity(GO:1904245) |
0.0 | 4.1 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
0.0 | 1.9 | GO:0042475 | odontogenesis of dentin-containing tooth(GO:0042475) |
0.0 | 0.2 | GO:0007406 | negative regulation of neuroblast proliferation(GO:0007406) |
0.0 | 0.3 | GO:0071763 | nuclear membrane organization(GO:0071763) |
0.0 | 0.9 | GO:0071384 | cellular response to corticosteroid stimulus(GO:0071384) cellular response to glucocorticoid stimulus(GO:0071385) |
0.0 | 0.2 | GO:0060501 | positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) |
0.0 | 0.8 | GO:0035025 | positive regulation of Rho protein signal transduction(GO:0035025) |
0.0 | 1.1 | GO:0060479 | lung cell differentiation(GO:0060479) lung epithelial cell differentiation(GO:0060487) |
0.0 | 0.2 | GO:0009396 | folic acid-containing compound biosynthetic process(GO:0009396) |
0.0 | 0.6 | GO:0045624 | positive regulation of T-helper cell differentiation(GO:0045624) |
0.0 | 0.1 | GO:0043586 | tongue development(GO:0043586) |
0.0 | 0.1 | GO:0045925 | positive regulation of female receptivity(GO:0045925) |
0.0 | 1.1 | GO:0030901 | midbrain development(GO:0030901) |
0.0 | 0.7 | GO:0043984 | histone H4-K16 acetylation(GO:0043984) |
0.0 | 0.8 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
0.0 | 0.5 | GO:0006999 | nuclear pore organization(GO:0006999) |
0.0 | 0.5 | GO:1902043 | positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043) |
0.0 | 0.1 | GO:1900377 | negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377) |
0.0 | 1.1 | GO:0032007 | negative regulation of TOR signaling(GO:0032007) |
0.0 | 0.1 | GO:0006933 | negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933) |
0.0 | 1.1 | GO:0071774 | response to fibroblast growth factor(GO:0071774) |
0.0 | 0.2 | GO:2000251 | positive regulation of actin cytoskeleton reorganization(GO:2000251) |
0.0 | 0.3 | GO:0045899 | positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899) |
0.0 | 1.9 | GO:0043488 | regulation of mRNA stability(GO:0043488) |
0.0 | 0.1 | GO:0051697 | protein delipidation(GO:0051697) |
0.0 | 1.4 | GO:0030168 | platelet activation(GO:0030168) |
0.0 | 0.2 | GO:0019388 | galactose catabolic process(GO:0019388) |
0.0 | 0.1 | GO:0090271 | positive regulation of fibroblast growth factor production(GO:0090271) |
0.0 | 0.1 | GO:0006432 | phenylalanyl-tRNA aminoacylation(GO:0006432) |
0.0 | 0.4 | GO:0007616 | long-term memory(GO:0007616) |
0.0 | 0.3 | GO:0003351 | epithelial cilium movement(GO:0003351) |
0.0 | 2.3 | GO:0030178 | negative regulation of Wnt signaling pathway(GO:0030178) |
0.0 | 0.7 | GO:0006367 | transcription initiation from RNA polymerase II promoter(GO:0006367) |
0.0 | 0.8 | GO:0007029 | endoplasmic reticulum organization(GO:0007029) |
0.0 | 0.1 | GO:0072189 | ureter development(GO:0072189) |
0.0 | 0.2 | GO:0045662 | negative regulation of myoblast differentiation(GO:0045662) |
0.0 | 0.6 | GO:0009060 | aerobic respiration(GO:0009060) |
0.0 | 3.4 | GO:0018105 | peptidyl-serine phosphorylation(GO:0018105) |
0.0 | 0.3 | GO:0050873 | brown fat cell differentiation(GO:0050873) |
0.0 | 0.4 | GO:0007566 | embryo implantation(GO:0007566) |
0.0 | 0.0 | GO:0034285 | response to sucrose(GO:0009744) response to disaccharide(GO:0034285) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 2.5 | GO:0032280 | symmetric synapse(GO:0032280) |
0.6 | 2.3 | GO:0060187 | cell pole(GO:0060187) |
0.5 | 3.1 | GO:0000172 | ribonuclease MRP complex(GO:0000172) |
0.5 | 2.9 | GO:0000444 | MIS12/MIND type complex(GO:0000444) |
0.5 | 2.8 | GO:0001674 | female germ cell nucleus(GO:0001674) |
0.3 | 1.2 | GO:0033093 | Weibel-Palade body(GO:0033093) |
0.3 | 4.1 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
0.3 | 7.1 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
0.2 | 1.1 | GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex(GO:0002193) |
0.2 | 2.3 | GO:0005915 | zonula adherens(GO:0005915) |
0.1 | 6.6 | GO:0002102 | podosome(GO:0002102) |
0.1 | 0.7 | GO:0072487 | MSL complex(GO:0072487) |
0.1 | 0.4 | GO:0043540 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540) |
0.1 | 4.8 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
0.1 | 1.9 | GO:0042788 | polysomal ribosome(GO:0042788) |
0.1 | 0.5 | GO:0071438 | NADPH oxidase complex(GO:0043020) invadopodium membrane(GO:0071438) |
0.1 | 0.3 | GO:0034684 | integrin alphav-beta5 complex(GO:0034684) |
0.1 | 13.7 | GO:0000792 | heterochromatin(GO:0000792) |
0.1 | 0.5 | GO:0070826 | paraferritin complex(GO:0070826) |
0.1 | 0.5 | GO:0031523 | Myb complex(GO:0031523) |
0.1 | 0.5 | GO:0044615 | nuclear pore nuclear basket(GO:0044615) |
0.1 | 3.0 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
0.1 | 2.4 | GO:0000788 | nuclear nucleosome(GO:0000788) |
0.1 | 0.5 | GO:0033269 | internode region of axon(GO:0033269) |
0.1 | 0.5 | GO:0016580 | Sin3 complex(GO:0016580) |
0.1 | 2.7 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
0.1 | 0.8 | GO:0042555 | MCM complex(GO:0042555) |
0.1 | 0.1 | GO:0044301 | climbing fiber(GO:0044301) |
0.1 | 0.5 | GO:1990316 | ATG1/ULK1 kinase complex(GO:1990316) |
0.0 | 1.1 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
0.0 | 0.6 | GO:0033655 | host cell cytoplasm(GO:0030430) host cell cytoplasm part(GO:0033655) |
0.0 | 0.3 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) |
0.0 | 0.2 | GO:0033063 | Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063) |
0.0 | 0.3 | GO:0045261 | mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261) |
0.0 | 0.3 | GO:0097550 | transcriptional preinitiation complex(GO:0097550) |
0.0 | 0.6 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
0.0 | 0.7 | GO:0033276 | transcription factor TFTC complex(GO:0033276) |
0.0 | 0.3 | GO:0042824 | MHC class I peptide loading complex(GO:0042824) |
0.0 | 0.3 | GO:0070852 | cell body fiber(GO:0070852) |
0.0 | 2.7 | GO:0043198 | dendritic shaft(GO:0043198) |
0.0 | 11.1 | GO:0005667 | transcription factor complex(GO:0005667) |
0.0 | 0.6 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
0.0 | 0.3 | GO:0045120 | pronucleus(GO:0045120) |
0.0 | 1.2 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
0.0 | 1.3 | GO:0005902 | microvillus(GO:0005902) |
0.0 | 0.4 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
0.0 | 0.8 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
0.0 | 0.2 | GO:0031045 | dense core granule(GO:0031045) |
0.0 | 0.2 | GO:0071439 | clathrin complex(GO:0071439) |
0.0 | 1.0 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
0.0 | 0.5 | GO:0097440 | apical dendrite(GO:0097440) |
0.0 | 1.9 | GO:0000776 | kinetochore(GO:0000776) |
0.0 | 1.2 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
0.0 | 0.2 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
0.0 | 0.1 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
0.0 | 0.5 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
0.0 | 0.4 | GO:0000786 | nucleosome(GO:0000786) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.7 | 12.2 | GO:0015016 | [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016) |
1.0 | 3.1 | GO:0000171 | ribonuclease MRP activity(GO:0000171) |
0.7 | 7.5 | GO:0051428 | peptide hormone receptor binding(GO:0051428) |
0.6 | 5.6 | GO:0031852 | mu-type opioid receptor binding(GO:0031852) |
0.5 | 7.1 | GO:0016863 | intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863) |
0.5 | 3.6 | GO:0070915 | lysophosphatidic acid receptor activity(GO:0070915) |
0.5 | 2.5 | GO:0031628 | opioid receptor binding(GO:0031628) |
0.4 | 1.7 | GO:0015254 | glycerol channel activity(GO:0015254) |
0.4 | 3.0 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
0.4 | 1.2 | GO:0019166 | trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166) |
0.3 | 1.3 | GO:0035515 | oxidative RNA demethylase activity(GO:0035515) |
0.3 | 4.5 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
0.3 | 1.2 | GO:0004030 | aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030) |
0.3 | 2.3 | GO:0039706 | co-receptor binding(GO:0039706) |
0.2 | 0.5 | GO:0070644 | vitamin D response element binding(GO:0070644) |
0.2 | 2.9 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
0.2 | 1.2 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
0.2 | 4.7 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
0.2 | 0.8 | GO:0004126 | cytidine deaminase activity(GO:0004126) |
0.2 | 2.3 | GO:0070097 | delta-catenin binding(GO:0070097) |
0.2 | 1.6 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
0.2 | 2.2 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
0.2 | 0.5 | GO:0030171 | voltage-gated proton channel activity(GO:0030171) |
0.1 | 0.9 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
0.1 | 0.5 | GO:0004427 | inorganic diphosphatase activity(GO:0004427) |
0.1 | 1.4 | GO:0048185 | activin binding(GO:0048185) |
0.1 | 4.4 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
0.1 | 2.1 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
0.1 | 2.6 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
0.1 | 3.7 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
0.1 | 0.9 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
0.1 | 14.1 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
0.1 | 1.0 | GO:0019865 | immunoglobulin binding(GO:0019865) |
0.1 | 0.7 | GO:0031419 | cobalamin binding(GO:0031419) |
0.1 | 4.8 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
0.1 | 1.1 | GO:1990405 | protein antigen binding(GO:1990405) |
0.1 | 2.8 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
0.1 | 0.5 | GO:0015086 | cadmium ion transmembrane transporter activity(GO:0015086) lead ion transmembrane transporter activity(GO:0015094) vanadium ion transmembrane transporter activity(GO:0015100) ferrous iron uptake transmembrane transporter activity(GO:0015639) |
0.1 | 0.9 | GO:0015187 | glycine transmembrane transporter activity(GO:0015187) |
0.1 | 1.9 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
0.1 | 0.3 | GO:0019960 | C-X3-C chemokine binding(GO:0019960) |
0.1 | 3.3 | GO:0015144 | carbohydrate transmembrane transporter activity(GO:0015144) carbohydrate transporter activity(GO:1901476) |
0.1 | 0.8 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
0.1 | 0.6 | GO:0086006 | voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006) |
0.1 | 0.5 | GO:0070728 | leucine binding(GO:0070728) |
0.1 | 1.1 | GO:0003688 | DNA replication origin binding(GO:0003688) |
0.1 | 0.9 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
0.1 | 0.5 | GO:0005025 | transforming growth factor beta receptor activity, type I(GO:0005025) |
0.1 | 2.0 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
0.1 | 0.3 | GO:0043532 | angiostatin binding(GO:0043532) |
0.1 | 0.4 | GO:0070095 | fructose-6-phosphate binding(GO:0070095) |
0.1 | 0.4 | GO:0008294 | calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294) |
0.1 | 1.9 | GO:0017091 | AU-rich element binding(GO:0017091) |
0.1 | 1.0 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
0.1 | 0.2 | GO:0004703 | G-protein coupled receptor kinase activity(GO:0004703) |
0.1 | 1.2 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
0.1 | 0.1 | GO:0008311 | double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311) |
0.1 | 1.0 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
0.1 | 0.3 | GO:0000990 | transcription factor activity, core RNA polymerase binding(GO:0000990) |
0.1 | 0.8 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
0.0 | 0.4 | GO:0004416 | hydroxyacylglutathione hydrolase activity(GO:0004416) |
0.0 | 0.6 | GO:0005537 | mannose binding(GO:0005537) |
0.0 | 0.1 | GO:0000099 | sulfur amino acid transmembrane transporter activity(GO:0000099) |
0.0 | 47.9 | GO:0043565 | sequence-specific DNA binding(GO:0043565) |
0.0 | 5.6 | GO:0016779 | nucleotidyltransferase activity(GO:0016779) |
0.0 | 1.1 | GO:0042605 | peptide antigen binding(GO:0042605) |
0.0 | 1.0 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
0.0 | 0.7 | GO:0008483 | transaminase activity(GO:0008483) |
0.0 | 0.9 | GO:0016780 | phosphotransferase activity, for other substituted phosphate groups(GO:0016780) |
0.0 | 0.1 | GO:0015183 | L-aspartate transmembrane transporter activity(GO:0015183) |
0.0 | 0.6 | GO:0010485 | H4 histone acetyltransferase activity(GO:0010485) |
0.0 | 0.1 | GO:0008988 | rRNA (adenine-N6-)-methyltransferase activity(GO:0008988) |
0.0 | 1.0 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
0.0 | 5.5 | GO:0000287 | magnesium ion binding(GO:0000287) |
0.0 | 1.6 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
0.0 | 0.4 | GO:0005172 | vascular endothelial growth factor receptor binding(GO:0005172) |
0.0 | 0.2 | GO:0042056 | chemoattractant activity(GO:0042056) |
0.0 | 0.3 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
0.0 | 0.1 | GO:0047256 | beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256) |
0.0 | 0.8 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
0.0 | 0.6 | GO:0003690 | double-stranded DNA binding(GO:0003690) |
0.0 | 0.3 | GO:0005521 | lamin binding(GO:0005521) |
0.0 | 0.4 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
0.0 | 0.5 | GO:0097602 | cullin family protein binding(GO:0097602) |
0.0 | 0.1 | GO:0004826 | phenylalanine-tRNA ligase activity(GO:0004826) |
0.0 | 0.2 | GO:0005542 | folic acid binding(GO:0005542) |
0.0 | 2.1 | GO:0051015 | actin filament binding(GO:0051015) |
0.0 | 1.7 | GO:0003774 | motor activity(GO:0003774) |
0.0 | 0.6 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
0.0 | 0.4 | GO:0030971 | receptor tyrosine kinase binding(GO:0030971) |
0.0 | 0.3 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 7.3 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
0.1 | 14.2 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
0.1 | 2.8 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
0.1 | 4.5 | PID_CD8_TCR_DOWNSTREAM_PATHWAY | Downstream signaling in naïve CD8+ T cells |
0.1 | 1.9 | PID_MYC_PATHWAY | C-MYC pathway |
0.1 | 4.1 | PID_BMP_PATHWAY | BMP receptor signaling |
0.1 | 2.8 | PID_WNT_NONCANONICAL_PATHWAY | Noncanonical Wnt signaling pathway |
0.1 | 3.6 | PID_AP1_PATHWAY | AP-1 transcription factor network |
0.0 | 1.6 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
0.0 | 2.3 | PID_ECADHERIN_STABILIZATION_PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
0.0 | 3.1 | PID_LYSOPHOSPHOLIPID_PATHWAY | LPA receptor mediated events |
0.0 | 0.5 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
0.0 | 0.9 | PID_PDGFRA_PATHWAY | PDGFR-alpha signaling pathway |
0.0 | 3.8 | PID_MYC_ACTIV_PATHWAY | Validated targets of C-MYC transcriptional activation |
0.0 | 1.0 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
0.0 | 0.5 | SA_B_CELL_RECEPTOR_COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
0.0 | 0.3 | PID_SYNDECAN_3_PATHWAY | Syndecan-3-mediated signaling events |
0.0 | 0.8 | PID_ATR_PATHWAY | ATR signaling pathway |
0.0 | 0.5 | PID_HIF2PATHWAY | HIF-2-alpha transcription factor network |
0.0 | 0.8 | PID_HES_HEY_PATHWAY | Notch-mediated HES/HEY network |
0.0 | 0.6 | PID_TCPTP_PATHWAY | Signaling events mediated by TCPTP |
0.0 | 0.3 | PID_EPHRINB_REV_PATHWAY | Ephrin B reverse signaling |
0.0 | 0.8 | PID_RAC1_REG_PATHWAY | Regulation of RAC1 activity |
0.0 | 0.6 | PID_PLK1_PATHWAY | PLK1 signaling events |
0.0 | 0.8 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 12.2 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
0.2 | 1.7 | REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
0.2 | 0.8 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
0.1 | 1.5 | REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION | Genes involved in FGFR1 ligand binding and activation |
0.1 | 10.5 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
0.1 | 1.9 | REACTOME_ERKS_ARE_INACTIVATED | Genes involved in ERKs are inactivated |
0.1 | 1.2 | REACTOME_INTRINSIC_PATHWAY | Genes involved in Intrinsic Pathway |
0.1 | 1.0 | REACTOME_GLUCURONIDATION | Genes involved in Glucuronidation |
0.1 | 9.8 | REACTOME_G_ALPHA_I_SIGNALLING_EVENTS | Genes involved in G alpha (i) signalling events |
0.1 | 1.1 | REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY | Genes involved in Notch-HLH transcription pathway |
0.1 | 0.7 | REACTOME_ACYL_CHAIN_REMODELLING_OF_PG | Genes involved in Acyl chain remodelling of PG |
0.1 | 0.5 | REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
0.0 | 0.8 | REACTOME_UNWINDING_OF_DNA | Genes involved in Unwinding of DNA |
0.0 | 0.5 | REACTOME_ERK_MAPK_TARGETS | Genes involved in ERK/MAPK targets |
0.0 | 2.3 | REACTOME_RNA_POL_I_PROMOTER_OPENING | Genes involved in RNA Polymerase I Promoter Opening |
0.0 | 1.3 | REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT | Genes involved in ABC-family proteins mediated transport |
0.0 | 0.9 | REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
0.0 | 1.2 | REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
0.0 | 0.9 | REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |
0.0 | 0.7 | REACTOME_N_GLYCAN_ANTENNAE_ELONGATION | Genes involved in N-Glycan antennae elongation |
0.0 | 3.3 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
0.0 | 2.0 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
0.0 | 0.3 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
0.0 | 1.1 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
0.0 | 0.6 | REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
0.0 | 0.7 | REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
0.0 | 0.6 | REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
0.0 | 1.0 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
0.0 | 1.0 | REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
0.0 | 0.8 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
0.0 | 1.4 | REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
0.0 | 0.5 | REACTOME_SULFUR_AMINO_ACID_METABOLISM | Genes involved in Sulfur amino acid metabolism |
0.0 | 0.3 | REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
0.0 | 0.5 | REACTOME_SIGNALING_BY_BMP | Genes involved in Signaling by BMP |
0.0 | 0.6 | REACTOME_GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
0.0 | 0.4 | REACTOME_SYNTHESIS_OF_PA | Genes involved in Synthesis of PA |
0.0 | 0.3 | REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS | Genes involved in Activation of BH3-only proteins |
0.0 | 0.2 | REACTOME_PECAM1_INTERACTIONS | Genes involved in PECAM1 interactions |