Motif ID: Mtf1

Z-value: 0.752


Transcription factors associated with Mtf1:

Gene SymbolEntrez IDGene Name
Mtf1 ENSMUSG00000028890.7 Mtf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mtf1mm10_v2_chr4_+_124802543_1248026780.253.2e-01Click!


Activity profile for motif Mtf1.

activity profile for motif Mtf1


Sorted Z-values histogram for motif Mtf1

Sorted Z-values for motif Mtf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Mtf1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_+_94172618 2.737 ENSMUST00000034214.6
Mt2
metallothionein 2
chr11_-_32222233 2.376 ENSMUST00000150381.1
ENSMUST00000144902.1
ENSMUST00000020524.8
Rhbdf1


rhomboid family 1 (Drosophila)


chr11_+_63133068 1.875 ENSMUST00000108700.1
Pmp22
peripheral myelin protein 22
chr11_+_63132569 1.665 ENSMUST00000108701.1
Pmp22
peripheral myelin protein 22
chr9_-_56635624 1.251 ENSMUST00000114256.1
Lingo1
leucine rich repeat and Ig domain containing 1
chr5_+_105415738 0.964 ENSMUST00000112707.1
Lrrc8b
leucine rich repeat containing 8 family, member B
chr9_-_112187898 0.898 ENSMUST00000178410.1
ENSMUST00000172380.3
Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr7_-_43313063 0.892 ENSMUST00000135130.1
ENSMUST00000139061.1
Zfp715

zinc finger protein 715

chr13_+_23934434 0.887 ENSMUST00000072391.1
Hist1h2aa
histone cluster 1, H2aa
chr15_-_58214882 0.853 ENSMUST00000022986.6
Fbxo32
F-box protein 32
chr4_+_103619580 0.828 ENSMUST00000106827.1
Dab1
disabled 1
chr17_-_83631892 0.778 ENSMUST00000051482.1
Kcng3
potassium voltage-gated channel, subfamily G, member 3
chr8_+_94179089 0.714 ENSMUST00000034215.6
Mt1
metallothionein 1
chr4_+_134496996 0.697 ENSMUST00000095074.3
Paqr7
progestin and adipoQ receptor family member VII
chr1_+_135729147 0.688 ENSMUST00000027677.7
Csrp1
cysteine and glycine-rich protein 1
chr1_-_166002613 0.610 ENSMUST00000177358.1
ENSMUST00000160908.1
ENSMUST00000027850.8
ENSMUST00000160260.2
Pou2f1



POU domain, class 2, transcription factor 1



chr10_+_17723220 0.589 ENSMUST00000038107.7
Cited2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
chr13_-_45964964 0.585 ENSMUST00000180110.1
ENSMUST00000091628.3
ENSMUST00000167708.2
Atxn1


ataxin 1


chr9_+_57940104 0.583 ENSMUST00000043059.7
Sema7a
sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
chr7_+_5056856 0.571 ENSMUST00000131368.1
ENSMUST00000123956.1
Ccdc106

coiled-coil domain containing 106

chr7_-_43313233 0.534 ENSMUST00000012796.7
ENSMUST00000107986.2
Zfp715

zinc finger protein 715

chr7_+_43579577 0.528 ENSMUST00000058104.7
Zfp719
zinc finger protein 719
chr1_-_166002591 0.500 ENSMUST00000111429.4
ENSMUST00000176800.1
Pou2f1

POU domain, class 2, transcription factor 1

chr2_-_91236877 0.499 ENSMUST00000111352.1
Ddb2
damage specific DNA binding protein 2
chr1_+_75400070 0.452 ENSMUST00000113589.1
Speg
SPEG complex locus
chr2_-_91236967 0.447 ENSMUST00000028696.4
Ddb2
damage specific DNA binding protein 2
chr3_-_94412883 0.435 ENSMUST00000181305.1
1700040D17Rik
RIKEN cDNA 1700040D17 gene
chr6_-_39118211 0.415 ENSMUST00000038398.6
Parp12
poly (ADP-ribose) polymerase family, member 12
chr1_-_64122256 0.396 ENSMUST00000135075.1
Klf7
Kruppel-like factor 7 (ubiquitous)
chr8_+_123373778 0.387 ENSMUST00000057934.3
ENSMUST00000108840.2
Tcf25

transcription factor 25 (basic helix-loop-helix)

chr16_-_91597636 0.381 ENSMUST00000023686.8
Tmem50b
transmembrane protein 50B
chr1_-_167393826 0.330 ENSMUST00000028005.2
Mgst3
microsomal glutathione S-transferase 3
chr1_+_66386968 0.309 ENSMUST00000145419.1
Map2
microtubule-associated protein 2
chr10_+_20952547 0.298 ENSMUST00000105525.4
Ahi1
Abelson helper integration site 1
chr10_-_81001338 0.268 ENSMUST00000099462.1
ENSMUST00000118233.1
Gng7

guanine nucleotide binding protein (G protein), gamma 7

chr11_-_5898771 0.261 ENSMUST00000102921.3
Myl7
myosin, light polypeptide 7, regulatory
chr2_-_173119402 0.241 ENSMUST00000094287.3
ENSMUST00000179693.1
Ctcfl

CCCTC-binding factor (zinc finger protein)-like

chr8_-_70776650 0.225 ENSMUST00000034296.8
Pik3r2
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta)
chr7_+_132610620 0.210 ENSMUST00000033241.5
Lhpp
phospholysine phosphohistidine inorganic pyrophosphate phosphatase
chr10_+_81136223 0.199 ENSMUST00000048128.8
Zbtb7a
zinc finger and BTB domain containing 7a
chr8_+_92827273 0.189 ENSMUST00000034187.7
Mmp2
matrix metallopeptidase 2
chr4_+_129985098 0.179 ENSMUST00000106017.1
ENSMUST00000121049.1
Bai2

brain-specific angiogenesis inhibitor 2

chr18_-_84589491 0.176 ENSMUST00000125763.1
Zfp407
zinc finger protein 407
chr17_-_56716788 0.166 ENSMUST00000067931.5
Vmac
vimentin-type intermediate filament associated coiled-coil protein
chr12_-_4592927 0.163 ENSMUST00000170816.1
Gm3625
predicted gene 3625
chr3_-_121815212 0.161 ENSMUST00000029770.5
Abcd3
ATP-binding cassette, sub-family D (ALD), member 3
chr1_+_179668202 0.158 ENSMUST00000040538.3
Sccpdh
saccharopine dehydrogenase (putative)
chr8_+_70905970 0.151 ENSMUST00000019405.2
Map1s
microtubule-associated protein 1S
chr1_+_128103297 0.150 ENSMUST00000036288.4
R3hdm1
R3H domain containing 1
chr6_+_90619241 0.145 ENSMUST00000032177.8
Slc41a3
solute carrier family 41, member 3
chr17_+_47688992 0.137 ENSMUST00000156118.1
Frs3
fibroblast growth factor receptor substrate 3
chr14_-_63543931 0.134 ENSMUST00000058679.5
Mtmr9
myotubularin related protein 9
chr5_-_123749393 0.134 ENSMUST00000057795.5
ENSMUST00000111515.1
ENSMUST00000182309.1
Rsrc2


arginine/serine-rich coiled-coil 2


chr6_-_56923927 0.128 ENSMUST00000031793.5
Nt5c3
5'-nucleotidase, cytosolic III
chr5_+_115506668 0.125 ENSMUST00000067268.8
ENSMUST00000086523.3
Pxn

paxillin

chr4_+_129984833 0.117 ENSMUST00000120204.1
Bai2
brain-specific angiogenesis inhibitor 2
chr13_-_23934156 0.112 ENSMUST00000052776.2
Hist1h2ba
histone cluster 1, H2ba
chr7_-_141539784 0.110 ENSMUST00000118694.1
ENSMUST00000153191.1
ENSMUST00000166082.1
ENSMUST00000026586.6
Chid1



chitinase domain containing 1



chr12_+_103532435 0.102 ENSMUST00000021631.5
Ppp4r4
protein phosphatase 4, regulatory subunit 4
chr10_-_39899238 0.096 ENSMUST00000178563.1
AA474331
expressed sequence AA474331
chr7_-_119793958 0.093 ENSMUST00000106523.1
ENSMUST00000063902.7
ENSMUST00000150844.1
Eri2


exoribonuclease 2


chr5_-_123749371 0.092 ENSMUST00000182955.1
ENSMUST00000182489.1
ENSMUST00000050827.7
Rsrc2


arginine/serine-rich coiled-coil 2


chr11_+_50131342 0.089 ENSMUST00000093138.6
ENSMUST00000101270.4
Tbc1d9b

TBC1 domain family, member 9B

chr5_+_142401484 0.085 ENSMUST00000072837.5
Foxk1
forkhead box K1
chr10_+_70245083 0.084 ENSMUST00000046807.6
Slc16a9
solute carrier family 16 (monocarboxylic acid transporters), member 9
chr2_+_91237110 0.083 ENSMUST00000181191.1
A330069E16Rik
RIKEN cDNA A330069E16 gene
chr3_-_58692391 0.081 ENSMUST00000070368.7
Siah2
seven in absentia 2
chr12_+_24572276 0.081 ENSMUST00000085553.5
Grhl1
grainyhead-like 1 (Drosophila)
chr16_-_22857514 0.071 ENSMUST00000004576.6
Tbccd1
TBCC domain containing 1
chr11_+_77216180 0.068 ENSMUST00000037912.5
ENSMUST00000156488.1
Ssh2

slingshot homolog 2 (Drosophila)

chr14_-_26170283 0.067 ENSMUST00000100809.4
Plac9b
placenta specific 9b
chr15_+_100469034 0.062 ENSMUST00000037001.8
Letmd1
LETM1 domain containing 1
chr9_+_78175898 0.057 ENSMUST00000180974.1
C920006O11Rik
RIKEN cDNA C920006O11 gene
chr19_-_4839286 0.053 ENSMUST00000037246.5
Ccs
copper chaperone for superoxide dismutase
chr6_+_37870786 0.041 ENSMUST00000120428.1
ENSMUST00000031859.7
Trim24

tripartite motif-containing 24

chr7_+_119794102 0.035 ENSMUST00000084644.2
2610020H08Rik
RIKEN cDNA 2610020H08 gene
chr1_+_191906743 0.030 ENSMUST00000044954.6
Slc30a1
solute carrier family 30 (zinc transporter), member 1
chr7_+_119793987 0.029 ENSMUST00000033218.8
ENSMUST00000106520.1
2610020H08Rik

RIKEN cDNA 2610020H08 gene

chr3_-_89960562 0.026 ENSMUST00000069805.7
Atp8b2
ATPase, class I, type 8B, member 2
chr4_-_43040279 0.022 ENSMUST00000107958.1
ENSMUST00000107959.1
ENSMUST00000152846.1
Fam214b


family with sequence similarity 214, member B


chr12_-_36156781 0.021 ENSMUST00000020856.4
Bzw2
basic leucine zipper and W2 domains 2
chr9_+_108490676 0.006 ENSMUST00000178075.1
ENSMUST00000085044.7
ENSMUST00000166103.2
ENSMUST00000006854.7
Usp19



ubiquitin specific peptidase 19




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.5 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.3 0.9 GO:0014877 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.3 0.8 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.2 3.5 GO:0032060 bleb assembly(GO:0032060)
0.2 1.1 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.1 0.6 GO:0061428 embryonic heart tube left/right pattern formation(GO:0060971) negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428)
0.1 0.9 GO:0006290 pyrimidine dimer repair(GO:0006290)
0.1 0.3 GO:0035844 positive regulation of polarized epithelial cell differentiation(GO:0030862) cloaca development(GO:0035844)
0.1 0.6 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.1 1.3 GO:0048715 negative regulation of oligodendrocyte differentiation(GO:0048715)
0.1 0.6 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.1 0.2 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.0 0.2 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.0 0.1 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0 2.4 GO:0042058 regulation of epidermal growth factor receptor signaling pathway(GO:0042058)
0.0 0.0 GO:0061687 detoxification of inorganic compound(GO:0061687)
0.0 0.3 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 0.9 GO:0034605 cellular response to heat(GO:0034605)
0.0 0.1 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.0 0.1 GO:0051661 maintenance of centrosome location(GO:0051661) maintenance of Golgi location(GO:0051684)
0.0 0.2 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 0.1 GO:0002934 desmosome organization(GO:0002934)
0.0 0.1 GO:0046085 adenosine metabolic process(GO:0046085)
0.0 0.1 GO:0046415 urate metabolic process(GO:0046415)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.5 GO:0043218 compact myelin(GO:0043218)
0.1 0.9 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0 0.2 GO:0045098 type III intermediate filament(GO:0045098)
0.0 0.6 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 0.3 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 0.3 GO:0036038 MKS complex(GO:0036038)
0.0 1.4 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.0 0.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.1 0.6 GO:0034046 poly(G) binding(GO:0034046)
0.1 0.2 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.0 0.6 GO:0050693 LBD domain binding(GO:0050693)
0.0 0.6 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.8 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 1.1 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0 0.3 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.0 0.1 GO:0004568 chitinase activity(GO:0004568)
0.0 0.2 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 0.2 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 2.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 1.0 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.4 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.8 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.0 0.9 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.8 GO:0005507 copper ion binding(GO:0005507)
0.0 0.3 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.2 GO:0019215 intermediate filament binding(GO:0019215)
0.0 0.0 GO:0034056 estrogen response element binding(GO:0034056)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.5 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.0 1.1 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.9 PID_FOXO_PATHWAY FoxO family signaling
0.0 0.8 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 1.3 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER Genes involved in Formation of incision complex in GG-NER
0.0 1.1 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 0.6 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.2 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.8 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.1 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.2 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix