Motif ID: Rest

Z-value: 3.598


Transcription factors associated with Rest:

Gene SymbolEntrez IDGene Name
Rest ENSMUSG00000029249.9 Rest

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Restmm10_v2_chr5_+_77265454_77265549-0.701.2e-03Click!


Activity profile for motif Rest.

activity profile for motif Rest


Sorted Z-values histogram for motif Rest

Sorted Z-values for motif Rest



Network of associatons between targets according to the STRING database.



First level regulatory network of Rest

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_42255704 20.497 ENSMUST00000087123.5
Golga7b
golgi autoantigen, golgin subfamily a, 7B
chr6_-_121473630 15.162 ENSMUST00000046373.5
Iqsec3
IQ motif and Sec7 domain 3
chr3_-_80802789 12.786 ENSMUST00000107745.1
ENSMUST00000075316.4
Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr5_-_121009510 12.756 ENSMUST00000079204.5
Rph3a
rabphilin 3A
chr2_-_25319095 11.628 ENSMUST00000114318.3
ENSMUST00000114310.3
ENSMUST00000114308.3
ENSMUST00000114317.3
ENSMUST00000028335.6
ENSMUST00000114314.3
ENSMUST00000114307.1
Grin1






glutamate receptor, ionotropic, NMDA1 (zeta 1)






chr11_+_74619594 11.063 ENSMUST00000100866.2
E130309D14Rik
RIKEN cDNA E130309D14 gene
chr11_-_35798884 10.932 ENSMUST00000160726.2
Fbll1
fibrillarin-like 1
chr9_+_40269430 10.439 ENSMUST00000171835.2
Scn3b
sodium channel, voltage-gated, type III, beta
chr12_-_70347536 10.141 ENSMUST00000110520.2
ENSMUST00000110522.2
ENSMUST00000167755.1
Trim9


tripartite motif-containing 9


chr7_-_27396542 9.749 ENSMUST00000108363.1
Sptbn4
spectrin beta, non-erythrocytic 4
chrX_-_73869804 9.362 ENSMUST00000066576.5
ENSMUST00000114430.1
L1cam

L1 cell adhesion molecule

chr9_+_40269273 9.264 ENSMUST00000176185.1
Scn3b
sodium channel, voltage-gated, type III, beta
chr9_+_40269202 9.114 ENSMUST00000114956.3
ENSMUST00000049941.5
Scn3b

sodium channel, voltage-gated, type III, beta

chr1_+_34579693 8.931 ENSMUST00000052670.8
Amer3
APC membrane recruitment 3
chr6_+_8948608 8.224 ENSMUST00000160300.1
Nxph1
neurexophilin 1
chr18_-_31447383 7.989 ENSMUST00000025110.3
Syt4
synaptotagmin IV
chr4_-_129121234 7.972 ENSMUST00000030572.3
Hpca
hippocalcin
chr11_+_80477015 7.518 ENSMUST00000053413.10
ENSMUST00000147694.1
Cdk5r1

cyclin-dependent kinase 5, regulatory subunit 1 (p35)

chr9_+_59578192 7.504 ENSMUST00000118549.1
ENSMUST00000034840.3
Celf6

CUGBP, Elav-like family member 6

chr2_+_132781278 7.197 ENSMUST00000028826.3
Chgb
chromogranin B
chr12_+_102949450 7.118 ENSMUST00000179002.1
Unc79
unc-79 homolog (C. elegans)
chr7_+_122671401 7.102 ENSMUST00000182095.1
Cacng3
calcium channel, voltage-dependent, gamma subunit 3
chr7_+_122671378 6.842 ENSMUST00000182563.1
Cacng3
calcium channel, voltage-dependent, gamma subunit 3
chr17_-_91092715 6.711 ENSMUST00000160800.2
ENSMUST00000159778.1
ENSMUST00000160844.3
Nrxn1


neurexin I


chr2_-_25319187 6.368 ENSMUST00000114312.1
Grin1
glutamate receptor, ionotropic, NMDA1 (zeta 1)
chr13_-_105054895 6.280 ENSMUST00000063551.5
Rgs7bp
regulator of G-protein signalling 7 binding protein
chr2_+_155775333 6.255 ENSMUST00000029141.5
Mmp24
matrix metallopeptidase 24
chr1_+_81077274 6.199 ENSMUST00000068275.5
ENSMUST00000113494.2
Nyap2

neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2

chr5_+_137030275 6.041 ENSMUST00000041543.8
Vgf
VGF nerve growth factor inducible
chrX_-_20920911 5.857 ENSMUST00000081893.6
ENSMUST00000115345.1
Syn1

synapsin I

chr9_-_57467985 5.847 ENSMUST00000046587.6
Scamp5
secretory carrier membrane protein 5
chr7_-_81493725 5.784 ENSMUST00000119121.1
Ap3b2
adaptor-related protein complex 3, beta 2 subunit
chr17_+_28575718 5.750 ENSMUST00000080780.6
Lhfpl5
lipoma HMGIC fusion partner-like 5
chr12_-_112511136 5.630 ENSMUST00000066791.5
Tmem179
transmembrane protein 179
chr13_-_54749627 5.611 ENSMUST00000099506.1
Gprin1
G protein-regulated inducer of neurite outgrowth 1
chr4_+_101550411 5.558 ENSMUST00000094953.4
ENSMUST00000106933.1
Dnajc6

DnaJ (Hsp40) homolog, subfamily C, member 6

chr9_+_108826320 4.971 ENSMUST00000024238.5
Celsr3
cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)
chr7_+_27653906 4.911 ENSMUST00000008088.7
Ttc9b
tetratricopeptide repeat domain 9B
chr7_-_81493883 4.853 ENSMUST00000082090.7
Ap3b2
adaptor-related protein complex 3, beta 2 subunit
chr15_-_76722161 4.723 ENSMUST00000049956.4
Lrrc24
leucine rich repeat containing 24
chr1_+_81077204 4.611 ENSMUST00000123720.1
Nyap2
neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2
chr17_-_83631892 4.317 ENSMUST00000051482.1
Kcng3
potassium voltage-gated channel, subfamily G, member 3
chr13_-_54749849 4.298 ENSMUST00000135343.1
Gprin1
G protein-regulated inducer of neurite outgrowth 1
chr2_-_27142429 4.158 ENSMUST00000151224.2
Fam163b
family with sequence similarity 163, member B
chr19_+_22139028 4.090 ENSMUST00000099569.2
ENSMUST00000087576.4
ENSMUST00000074770.5
Trpm3


transient receptor potential cation channel, subfamily M, member 3


chr2_-_181314500 3.839 ENSMUST00000103045.3
Stmn3
stathmin-like 3
chr11_-_3774706 3.546 ENSMUST00000155197.1
Osbp2
oxysterol binding protein 2
chr3_-_89764581 3.515 ENSMUST00000029562.3
Chrnb2
cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)
chr16_-_37384915 3.367 ENSMUST00000114787.1
ENSMUST00000114782.1
ENSMUST00000023526.2
ENSMUST00000114775.1
Stxbp5l



syntaxin binding protein 5-like



chr2_+_22622183 3.241 ENSMUST00000028123.3
Gad2
glutamic acid decarboxylase 2
chr12_+_119945957 3.143 ENSMUST00000058644.8
Tmem196
transmembrane protein 196
chr15_-_11037968 3.134 ENSMUST00000058007.5
Rxfp3
relaxin family peptide receptor 3
chr11_-_117873433 3.101 ENSMUST00000033230.7
Tha1
threonine aldolase 1
chr4_+_129136948 2.875 ENSMUST00000102600.3
Fndc5
fibronectin type III domain containing 5
chr11_+_102393403 2.665 ENSMUST00000107105.2
ENSMUST00000107102.1
ENSMUST00000107103.1
ENSMUST00000006750.7
Rundc3a



RUN domain containing 3A



chrX_+_7638674 2.488 ENSMUST00000128890.1
Syp
synaptophysin
chr19_-_45046614 2.473 ENSMUST00000145391.1
Pdzd7
PDZ domain containing 7
chr1_-_193035651 2.368 ENSMUST00000016344.7
Syt14
synaptotagmin XIV
chr9_+_104569671 2.329 ENSMUST00000057742.8
Cpne4
copine IV
chr12_+_102554966 2.329 ENSMUST00000021610.5
Chga
chromogranin A
chr17_-_72603709 2.283 ENSMUST00000086639.4
Alk
anaplastic lymphoma kinase
chr9_+_104569754 2.162 ENSMUST00000077190.6
Cpne4
copine IV
chr15_-_76521902 2.109 ENSMUST00000164703.1
ENSMUST00000096365.3
Scrt1

scratch homolog 1, zinc finger protein (Drosophila)

chr4_+_15881255 1.982 ENSMUST00000029876.1
Calb1
calbindin 1
chr9_-_22085391 1.540 ENSMUST00000179422.1
ENSMUST00000098937.3
ENSMUST00000177967.1
ENSMUST00000180180.1
Ecsit



ECSIT homolog (Drosophila)



chr9_+_122117375 1.495 ENSMUST00000118886.1
Snrk
SNF related kinase
chr12_+_113140198 1.452 ENSMUST00000084882.4
Crip2
cysteine rich protein 2
chr17_-_23740301 1.226 ENSMUST00000024702.3
Paqr4
progestin and adipoQ receptor family member IV
chr16_-_37384940 1.065 ENSMUST00000114781.1
ENSMUST00000114780.1
Stxbp5l

syntaxin binding protein 5-like

chr9_+_122117258 0.928 ENSMUST00000146832.1
ENSMUST00000139181.1
Snrk

SNF related kinase

chr13_-_56895737 0.913 ENSMUST00000022023.6
ENSMUST00000109871.1
Trpc7

transient receptor potential cation channel, subfamily C, member 7

chr11_+_77930800 0.725 ENSMUST00000093995.3
ENSMUST00000000646.7
Sez6

seizure related gene 6

chr5_-_116591811 0.695 ENSMUST00000076124.5
Srrm4
serine/arginine repetitive matrix 4
chr2_-_92401237 0.619 ENSMUST00000050312.2
Mapk8ip1
mitogen-activated protein kinase 8 interacting protein 1
chr9_+_122117338 0.607 ENSMUST00000120173.1
ENSMUST00000134949.1
ENSMUST00000119215.1
Snrk


SNF related kinase


chr1_-_84696182 0.445 ENSMUST00000049126.6
Dner
delta/notch-like EGF-related receptor
chr1_-_162548484 0.444 ENSMUST00000028017.9
Mettl13
methyltransferase like 13
chr17_-_25240112 0.439 ENSMUST00000038973.6
ENSMUST00000115154.4
Gnptg

N-acetylglucosamine-1-phosphotransferase, gamma subunit

chr8_+_18846251 0.399 ENSMUST00000149565.1
ENSMUST00000033847.4
Agpat5

1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)

chr13_+_54371340 0.296 ENSMUST00000026985.8
Cplx2
complexin 2
chr10_+_90829409 0.289 ENSMUST00000182202.1
ENSMUST00000182966.1
Anks1b

ankyrin repeat and sterile alpha motif domain containing 1B

chr10_+_90829538 0.275 ENSMUST00000179694.2
Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr6_+_113282302 0.149 ENSMUST00000041203.5
Cpne9
copine family member IX

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
6.4 25.5 GO:0021586 pons maturation(GO:0021586)
3.2 28.8 GO:0060373 regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371) regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
2.7 8.0 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
2.2 10.9 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
2.0 18.1 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
1.9 20.5 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
1.7 6.7 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
1.6 9.7 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
1.2 3.5 GO:0060084 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) synaptic transmission involved in micturition(GO:0060084)
1.0 3.1 GO:0006566 threonine metabolic process(GO:0006566)
1.0 3.8 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.9 9.4 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.8 2.5 GO:0038003 opioid receptor signaling pathway(GO:0038003) regulation of opioid receptor signaling pathway(GO:2000474)
0.8 5.0 GO:0036515 serotonergic neuron axon guidance(GO:0036515)
0.8 2.3 GO:1901079 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738) positive regulation of relaxation of muscle(GO:1901079)
0.7 7.1 GO:0048149 behavioral response to ethanol(GO:0048149)
0.7 3.9 GO:0072318 clathrin coat disassembly(GO:0072318)
0.6 3.2 GO:0006538 glutamate catabolic process(GO:0006538)
0.6 15.2 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.6 6.3 GO:0044331 cell-cell adhesion mediated by cadherin(GO:0044331)
0.5 8.2 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.5 13.9 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.5 6.0 GO:0043084 penile erection(GO:0043084)
0.5 10.6 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.5 12.8 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.5 5.9 GO:0097091 synaptic vesicle clustering(GO:0097091)
0.4 2.0 GO:0072235 distal convoluted tubule development(GO:0072025) metanephric distal convoluted tubule development(GO:0072221) metanephric distal tubule development(GO:0072235)
0.4 5.8 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.4 12.8 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.4 2.9 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.3 7.5 GO:0071625 vocalization behavior(GO:0071625)
0.2 2.7 GO:0030828 positive regulation of cGMP biosynthetic process(GO:0030828)
0.2 2.3 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.2 3.1 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.1 0.4 GO:0016256 N-glycan processing to lysosome(GO:0016256)
0.1 0.6 GO:0007258 JUN phosphorylation(GO:0007258)
0.1 4.4 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.1 10.8 GO:0014065 phosphatidylinositol 3-kinase signaling(GO:0014065)
0.1 4.7 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.6 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.0 2.1 GO:2001222 regulation of neuron migration(GO:2001222)
0.0 0.3 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
0.0 0.9 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.7 GO:0060074 synapse maturation(GO:0060074)
0.0 0.4 GO:0007220 Notch receptor processing(GO:0007220)
0.0 0.1 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 3.5 GO:0007286 spermatid development(GO:0007286)
0.0 1.5 GO:0051341 regulation of oxidoreductase activity(GO:0051341)
0.0 6.2 GO:0060828 regulation of canonical Wnt signaling pathway(GO:0060828)
0.0 4.3 GO:0071805 potassium ion transmembrane transport(GO:0071805)
0.0 2.4 GO:0006906 vesicle fusion(GO:0006906)
0.0 0.7 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
4.5 18.0 GO:0044307 dendritic branch(GO:0044307)
2.5 7.5 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
1.9 28.8 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
1.7 20.5 GO:0002178 palmitoyltransferase complex(GO:0002178)
1.6 9.7 GO:0008091 spectrin(GO:0008091)
1.6 10.9 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.8 10.0 GO:0044294 dendritic growth cone(GO:0044294)
0.8 10.6 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.8 8.0 GO:0044327 dendritic spine head(GO:0044327)
0.7 6.7 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.6 2.5 GO:0002141 stereocilia ankle link(GO:0002141)
0.6 26.7 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.6 5.7 GO:0032426 stereocilium tip(GO:0032426)
0.5 18.4 GO:0060077 inhibitory synapse(GO:0060077)
0.5 8.0 GO:0097449 astrocyte projection(GO:0097449)
0.5 2.3 GO:0042583 chromaffin granule(GO:0042583)
0.3 10.4 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.3 3.5 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.2 16.2 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 0.3 GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.1 4.3 GO:0097440 apical dendrite(GO:0097440)
0.1 6.0 GO:0030667 secretory granule membrane(GO:0030667)
0.1 8.5 GO:0008021 synaptic vesicle(GO:0008021)
0.1 4.3 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 2.0 GO:0043195 terminal bouton(GO:0043195)
0.0 3.7 GO:0030141 secretory granule(GO:0030141)
0.0 0.9 GO:0005801 cis-Golgi network(GO:0005801)
0.0 2.9 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 4.5 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.1 28.8 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
3.0 18.0 GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
2.6 12.8 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
2.0 8.0 GO:0030348 syntaxin-3 binding(GO:0030348)
1.6 9.4 GO:0033691 sialic acid binding(GO:0033691)
1.3 12.8 GO:0042301 phosphate ion binding(GO:0042301)
1.0 3.1 GO:0008732 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.9 2.7 GO:0030249 guanylate cyclase regulator activity(GO:0030249)
0.8 3.1 GO:0004966 galanin receptor activity(GO:0004966)
0.7 20.5 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.7 10.9 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.6 6.7 GO:0097109 neuroligin family protein binding(GO:0097109)
0.5 15.2 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.5 3.2 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.4 3.5 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.3 13.9 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.3 7.5 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.2 4.3 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.2 9.7 GO:0030507 spectrin binding(GO:0030507)
0.2 8.9 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.1 19.7 GO:0000149 SNARE binding(GO:0000149)
0.1 2.5 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 0.4 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.1 5.9 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 0.9 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 6.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 3.5 GO:0015485 cholesterol binding(GO:0015485)
0.1 8.9 GO:0051219 phosphoprotein binding(GO:0051219)
0.0 2.0 GO:0005496 steroid binding(GO:0005496)
0.0 5.6 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.6 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 2.3 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0 4.1 GO:0005261 cation channel activity(GO:0005261)
0.0 0.9 GO:0005179 hormone activity(GO:0005179)
0.0 1.5 GO:0016651 oxidoreductase activity, acting on NAD(P)H(GO:0016651)
0.0 0.4 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 8.0 GO:0003779 actin binding(GO:0003779)
0.0 0.6 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 3.0 GO:0000287 magnesium ion binding(GO:0000287)
0.0 0.4 GO:0005112 Notch binding(GO:0005112)
0.0 3.8 GO:0015631 tubulin binding(GO:0015631)
0.0 2.2 GO:0004930 G-protein coupled receptor activity(GO:0004930)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 12.8 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.2 9.4 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.2 28.8 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.2 7.5 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 6.3 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.6 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 47.9 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
1.1 30.8 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.5 13.9 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.4 3.5 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.4 6.3 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.4 5.9 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.4 7.5 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.2 5.6 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.2 0.9 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.1 1.6 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 4.3 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 10.1 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 1.5 REACTOME_TRAF6_MEDIATED_INDUCTION_OF_NFKB_AND_MAP_KINASES_UPON_TLR7_8_OR_9_ACTIVATION Genes involved in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
0.0 0.4 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.4 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA