Motif ID: Klf8
Z-value: 1.015

Transcription factors associated with Klf8:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Klf8 | ENSMUSG00000041649.7 | Klf8 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Klf8 | mm10_v2_chrX_+_153359613_153359613 | -0.86 | 5.6e-06 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.3 | 3.8 | GO:0046022 | regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022) |
0.7 | 2.9 | GO:0060741 | prostate gland stromal morphogenesis(GO:0060741) |
0.7 | 2.2 | GO:0060598 | dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598) |
0.7 | 4.2 | GO:0072513 | positive regulation of secondary heart field cardioblast proliferation(GO:0072513) |
0.7 | 2.0 | GO:0036166 | phenotypic switching(GO:0036166) |
0.6 | 1.9 | GO:1904274 | tricellular tight junction assembly(GO:1904274) |
0.6 | 3.9 | GO:0006369 | termination of RNA polymerase II transcription(GO:0006369) |
0.5 | 1.0 | GO:0016115 | terpenoid catabolic process(GO:0016115) |
0.5 | 3.9 | GO:0072615 | interleukin-17 secretion(GO:0072615) |
0.5 | 1.4 | GO:0010725 | regulation of primitive erythrocyte differentiation(GO:0010725) |
0.4 | 7.1 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
0.4 | 1.3 | GO:1903225 | negative regulation of endodermal cell differentiation(GO:1903225) |
0.4 | 1.3 | GO:0035880 | embryonic nail plate morphogenesis(GO:0035880) |
0.4 | 2.1 | GO:0018002 | N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920) |
0.4 | 0.4 | GO:0070094 | positive regulation of glucagon secretion(GO:0070094) |
0.4 | 2.0 | GO:1903553 | positive regulation of extracellular exosome assembly(GO:1903553) |
0.4 | 1.2 | GO:0030200 | heparan sulfate proteoglycan catabolic process(GO:0030200) |
0.4 | 1.5 | GO:0060745 | mammary gland branching involved in pregnancy(GO:0060745) |
0.4 | 3.9 | GO:0042487 | regulation of odontogenesis of dentin-containing tooth(GO:0042487) |
0.3 | 3.8 | GO:0048385 | regulation of retinoic acid receptor signaling pathway(GO:0048385) |
0.3 | 2.0 | GO:0060242 | contact inhibition(GO:0060242) |
0.3 | 1.0 | GO:0048687 | positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) |
0.3 | 2.0 | GO:0016576 | histone dephosphorylation(GO:0016576) |
0.3 | 0.8 | GO:0060489 | orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490) |
0.3 | 0.8 | GO:0036388 | pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) DNA replication preinitiation complex assembly(GO:0071163) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299) |
0.2 | 1.2 | GO:0051309 | female meiosis chromosome separation(GO:0051309) |
0.2 | 1.6 | GO:0000320 | re-entry into mitotic cell cycle(GO:0000320) |
0.2 | 0.7 | GO:2000418 | positive regulation of eosinophil migration(GO:2000418) |
0.2 | 1.5 | GO:2001185 | regulation of CD8-positive, alpha-beta T cell activation(GO:2001185) |
0.2 | 0.6 | GO:0070093 | negative regulation of glucagon secretion(GO:0070093) |
0.2 | 0.6 | GO:0002408 | myeloid dendritic cell chemotaxis(GO:0002408) |
0.2 | 0.7 | GO:0060578 | extraocular skeletal muscle development(GO:0002074) subthalamic nucleus development(GO:0021763) left lung morphogenesis(GO:0060460) pulmonary vein morphogenesis(GO:0060577) superior vena cava morphogenesis(GO:0060578) |
0.2 | 1.3 | GO:0021913 | regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913) |
0.2 | 0.4 | GO:0060750 | epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750) |
0.2 | 1.0 | GO:0032439 | endosome localization(GO:0032439) |
0.2 | 0.6 | GO:0060265 | positive regulation of respiratory burst involved in inflammatory response(GO:0060265) |
0.2 | 0.8 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
0.2 | 0.9 | GO:0042276 | error-prone translesion synthesis(GO:0042276) |
0.2 | 0.5 | GO:0046671 | regulation of cellular pH reduction(GO:0032847) negative regulation of retinal cell programmed cell death(GO:0046671) |
0.1 | 1.5 | GO:0042473 | outer ear morphogenesis(GO:0042473) |
0.1 | 0.7 | GO:0010637 | negative regulation of mitochondrial fusion(GO:0010637) |
0.1 | 1.4 | GO:0021796 | cerebral cortex regionalization(GO:0021796) |
0.1 | 0.3 | GO:0035984 | response to trichostatin A(GO:0035983) cellular response to trichostatin A(GO:0035984) |
0.1 | 0.6 | GO:0090666 | scaRNA localization to Cajal body(GO:0090666) |
0.1 | 0.9 | GO:0045743 | positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743) protein kinase D signaling(GO:0089700) |
0.1 | 1.0 | GO:0046826 | negative regulation of protein export from nucleus(GO:0046826) |
0.1 | 0.3 | GO:0010643 | cell communication by chemical coupling(GO:0010643) negative regulation of locomotion involved in locomotory behavior(GO:0090327) |
0.1 | 0.4 | GO:1902340 | telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340) |
0.1 | 0.4 | GO:0000160 | phosphorelay signal transduction system(GO:0000160) |
0.1 | 0.5 | GO:1902965 | regulation of protein localization to early endosome(GO:1902965) positive regulation of protein localization to early endosome(GO:1902966) |
0.1 | 2.2 | GO:0043486 | histone exchange(GO:0043486) |
0.1 | 0.6 | GO:2000271 | positive regulation of fibroblast apoptotic process(GO:2000271) |
0.1 | 0.3 | GO:0031508 | chromatin remodeling at centromere(GO:0031055) pericentric heterochromatin assembly(GO:0031508) |
0.1 | 0.4 | GO:2001271 | negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271) |
0.1 | 0.7 | GO:1990845 | adaptive thermogenesis(GO:1990845) |
0.1 | 0.5 | GO:0030916 | otic vesicle formation(GO:0030916) |
0.1 | 0.7 | GO:0015074 | DNA integration(GO:0015074) |
0.1 | 0.4 | GO:0040032 | post-embryonic body morphogenesis(GO:0040032) |
0.1 | 0.8 | GO:0001842 | neural fold formation(GO:0001842) |
0.1 | 0.7 | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) |
0.1 | 0.3 | GO:0043328 | protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328) |
0.1 | 1.9 | GO:0045662 | negative regulation of myoblast differentiation(GO:0045662) |
0.1 | 1.1 | GO:0060307 | regulation of ventricular cardiac muscle cell membrane repolarization(GO:0060307) |
0.1 | 0.2 | GO:0007521 | muscle cell fate determination(GO:0007521) mammary placode formation(GO:0060596) |
0.1 | 2.7 | GO:0009299 | mRNA transcription(GO:0009299) |
0.1 | 0.2 | GO:0061763 | multivesicular body-lysosome fusion(GO:0061763) |
0.1 | 3.0 | GO:1902476 | chloride transmembrane transport(GO:1902476) |
0.1 | 0.5 | GO:0000056 | ribosomal small subunit export from nucleus(GO:0000056) |
0.1 | 0.5 | GO:0031086 | nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087) |
0.1 | 0.7 | GO:1901386 | negative regulation of voltage-gated calcium channel activity(GO:1901386) |
0.1 | 0.2 | GO:0007056 | spindle assembly involved in female meiosis(GO:0007056) |
0.1 | 0.2 | GO:0010579 | regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579) |
0.1 | 0.3 | GO:0035553 | oxidative single-stranded RNA demethylation(GO:0035553) |
0.1 | 0.1 | GO:0031938 | regulation of chromatin silencing at telomere(GO:0031938) |
0.1 | 0.4 | GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) |
0.1 | 0.7 | GO:0045647 | negative regulation of erythrocyte differentiation(GO:0045647) |
0.1 | 0.2 | GO:1904451 | regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904451) positive regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904453) |
0.1 | 0.5 | GO:0097421 | liver regeneration(GO:0097421) |
0.1 | 1.0 | GO:1901741 | positive regulation of myoblast fusion(GO:1901741) |
0.1 | 0.2 | GO:0019401 | alditol biosynthetic process(GO:0019401) |
0.1 | 1.0 | GO:0038092 | nodal signaling pathway(GO:0038092) |
0.1 | 0.7 | GO:0099628 | receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628) |
0.1 | 0.9 | GO:0051451 | myoblast migration(GO:0051451) |
0.1 | 0.3 | GO:2000623 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623) |
0.1 | 1.6 | GO:0018345 | protein palmitoylation(GO:0018345) |
0.1 | 0.2 | GO:2000054 | regulation of chondrocyte development(GO:0061181) regulation of centromeric sister chromatid cohesion(GO:0070602) regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000053) negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054) |
0.1 | 0.8 | GO:0051639 | actin filament network formation(GO:0051639) |
0.1 | 0.8 | GO:2000353 | positive regulation of endothelial cell apoptotic process(GO:2000353) |
0.0 | 0.2 | GO:0046864 | retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865) alveolar primary septum development(GO:0061143) |
0.0 | 0.2 | GO:0006447 | regulation of translational initiation by iron(GO:0006447) positive regulation of translational initiation by iron(GO:0045994) |
0.0 | 0.1 | GO:0098974 | postsynaptic actin cytoskeleton organization(GO:0098974) |
0.0 | 0.7 | GO:0046697 | decidualization(GO:0046697) |
0.0 | 0.5 | GO:0072189 | ureter development(GO:0072189) |
0.0 | 0.2 | GO:0060903 | positive regulation of meiosis I(GO:0060903) |
0.0 | 1.1 | GO:0006346 | methylation-dependent chromatin silencing(GO:0006346) |
0.0 | 0.5 | GO:0006337 | nucleosome disassembly(GO:0006337) |
0.0 | 0.2 | GO:0002317 | plasma cell differentiation(GO:0002317) |
0.0 | 0.2 | GO:0034773 | histone H4-K20 trimethylation(GO:0034773) establishment of Sertoli cell barrier(GO:0097368) |
0.0 | 0.3 | GO:2001223 | negative regulation of neuron migration(GO:2001223) |
0.0 | 0.5 | GO:0070633 | transepithelial transport(GO:0070633) |
0.0 | 1.3 | GO:0030513 | positive regulation of BMP signaling pathway(GO:0030513) |
0.0 | 0.1 | GO:0014005 | microglia differentiation(GO:0014004) microglia development(GO:0014005) |
0.0 | 0.3 | GO:0006621 | protein retention in ER lumen(GO:0006621) |
0.0 | 0.7 | GO:0008535 | respiratory chain complex IV assembly(GO:0008535) |
0.0 | 0.4 | GO:0043011 | myeloid dendritic cell differentiation(GO:0043011) |
0.0 | 0.1 | GO:0010641 | positive regulation of platelet-derived growth factor receptor signaling pathway(GO:0010641) |
0.0 | 1.0 | GO:0006783 | heme biosynthetic process(GO:0006783) |
0.0 | 0.5 | GO:0002467 | germinal center formation(GO:0002467) |
0.0 | 0.6 | GO:0045780 | positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852) |
0.0 | 0.1 | GO:0009597 | detection of virus(GO:0009597) |
0.0 | 0.1 | GO:1904431 | positive regulation of t-circle formation(GO:1904431) |
0.0 | 0.5 | GO:0046498 | S-adenosylhomocysteine metabolic process(GO:0046498) |
0.0 | 0.6 | GO:0060216 | definitive hemopoiesis(GO:0060216) |
0.0 | 0.4 | GO:0071670 | smooth muscle cell chemotaxis(GO:0071670) |
0.0 | 1.0 | GO:0006270 | DNA replication initiation(GO:0006270) |
0.0 | 0.2 | GO:0043568 | positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568) |
0.0 | 0.1 | GO:0033762 | response to glucagon(GO:0033762) response to mercury ion(GO:0046689) |
0.0 | 0.3 | GO:0042135 | neurotransmitter catabolic process(GO:0042135) |
0.0 | 0.1 | GO:2000672 | negative regulation of motor neuron apoptotic process(GO:2000672) |
0.0 | 0.2 | GO:0006362 | transcription elongation from RNA polymerase I promoter(GO:0006362) |
0.0 | 0.2 | GO:0032286 | central nervous system myelin maintenance(GO:0032286) |
0.0 | 0.2 | GO:2000507 | positive regulation of energy homeostasis(GO:2000507) |
0.0 | 0.1 | GO:0034421 | post-translational protein acetylation(GO:0034421) |
0.0 | 0.2 | GO:0060732 | positive regulation of inositol phosphate biosynthetic process(GO:0060732) |
0.0 | 0.2 | GO:0036444 | calcium ion transmembrane import into mitochondrion(GO:0036444) |
0.0 | 0.4 | GO:0043984 | histone H4-K16 acetylation(GO:0043984) |
0.0 | 0.8 | GO:0006506 | GPI anchor biosynthetic process(GO:0006506) |
0.0 | 1.0 | GO:0042073 | intraciliary transport(GO:0042073) |
0.0 | 1.5 | GO:0006096 | glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757) |
0.0 | 0.3 | GO:0042711 | maternal behavior(GO:0042711) |
0.0 | 0.2 | GO:1903963 | arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963) |
0.0 | 0.2 | GO:0043923 | positive regulation by host of viral transcription(GO:0043923) |
0.0 | 0.2 | GO:0060033 | anatomical structure regression(GO:0060033) |
0.0 | 0.2 | GO:0032287 | peripheral nervous system myelin maintenance(GO:0032287) |
0.0 | 1.0 | GO:0007019 | microtubule depolymerization(GO:0007019) |
0.0 | 0.3 | GO:0045742 | positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742) positive regulation of ERBB signaling pathway(GO:1901186) |
0.0 | 0.9 | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) |
0.0 | 0.3 | GO:0050953 | visual perception(GO:0007601) sensory perception of light stimulus(GO:0050953) |
0.0 | 0.4 | GO:1903077 | negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376) |
0.0 | 0.2 | GO:0014067 | negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067) |
0.0 | 0.1 | GO:2000210 | positive regulation of anoikis(GO:2000210) |
0.0 | 0.3 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
0.0 | 0.1 | GO:0070814 | hydrogen sulfide biosynthetic process(GO:0070814) |
0.0 | 0.5 | GO:0030279 | negative regulation of ossification(GO:0030279) |
0.0 | 0.3 | GO:0016180 | snRNA processing(GO:0016180) |
0.0 | 0.2 | GO:0071364 | cellular response to epidermal growth factor stimulus(GO:0071364) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.3 | 4.0 | GO:0031680 | G-protein beta/gamma-subunit complex(GO:0031680) |
1.0 | 3.0 | GO:0030868 | smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425) |
0.7 | 2.0 | GO:0071149 | TEAD-2-YAP complex(GO:0071149) |
0.4 | 2.7 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
0.4 | 1.3 | GO:0005588 | collagen type V trimer(GO:0005588) |
0.3 | 1.0 | GO:0097058 | CRLF-CLCF1 complex(GO:0097058) |
0.3 | 1.9 | GO:0061689 | tricellular tight junction(GO:0061689) |
0.3 | 2.1 | GO:0031415 | NatA complex(GO:0031415) |
0.3 | 0.8 | GO:0036387 | nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387) |
0.2 | 0.7 | GO:0099573 | glutamatergic postsynaptic density(GO:0099573) |
0.2 | 1.5 | GO:0097550 | transcriptional preinitiation complex(GO:0097550) |
0.2 | 0.8 | GO:0060187 | cell pole(GO:0060187) |
0.2 | 0.8 | GO:0090537 | CERF complex(GO:0090537) |
0.2 | 0.9 | GO:0008622 | epsilon DNA polymerase complex(GO:0008622) |
0.2 | 1.5 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
0.1 | 0.4 | GO:0005899 | insulin receptor complex(GO:0005899) |
0.1 | 0.8 | GO:0005859 | muscle myosin complex(GO:0005859) |
0.1 | 1.2 | GO:0000796 | condensin complex(GO:0000796) |
0.1 | 0.3 | GO:0000814 | ESCRT II complex(GO:0000814) |
0.1 | 0.5 | GO:0034448 | EGO complex(GO:0034448) |
0.1 | 0.4 | GO:0072487 | MSL complex(GO:0072487) |
0.1 | 0.3 | GO:1902737 | dendritic filopodium(GO:1902737) |
0.1 | 1.1 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
0.1 | 1.0 | GO:0042555 | MCM complex(GO:0042555) |
0.1 | 0.5 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
0.1 | 0.5 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
0.1 | 0.4 | GO:0001740 | Barr body(GO:0001740) |
0.1 | 0.2 | GO:0097574 | lateral part of cell(GO:0097574) basolateral part of cell(GO:1990794) rod bipolar cell terminal bouton(GO:1990795) |
0.1 | 2.0 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
0.1 | 1.3 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
0.1 | 0.5 | GO:0031254 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
0.1 | 6.1 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
0.1 | 0.8 | GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506) |
0.0 | 0.8 | GO:0035253 | ciliary rootlet(GO:0035253) |
0.0 | 0.5 | GO:0046930 | pore complex(GO:0046930) |
0.0 | 0.5 | GO:0071564 | npBAF complex(GO:0071564) |
0.0 | 0.7 | GO:0005839 | proteasome core complex(GO:0005839) |
0.0 | 0.2 | GO:0030991 | intraciliary transport particle A(GO:0030991) |
0.0 | 0.3 | GO:0031209 | SCAR complex(GO:0031209) |
0.0 | 0.6 | GO:0005697 | telomerase holoenzyme complex(GO:0005697) |
0.0 | 0.2 | GO:0032591 | dendritic spine membrane(GO:0032591) |
0.0 | 0.2 | GO:0055037 | recycling endosome(GO:0055037) |
0.0 | 0.1 | GO:0031933 | telomeric heterochromatin(GO:0031933) |
0.0 | 1.2 | GO:0005844 | polysome(GO:0005844) |
0.0 | 1.0 | GO:0005871 | kinesin complex(GO:0005871) |
0.0 | 0.3 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
0.0 | 0.3 | GO:0032039 | integrator complex(GO:0032039) |
0.0 | 1.3 | GO:0070469 | respiratory chain(GO:0070469) |
0.0 | 6.4 | GO:0005667 | transcription factor complex(GO:0005667) |
0.0 | 0.4 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
0.0 | 1.1 | GO:0005902 | microvillus(GO:0005902) |
0.0 | 0.6 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
0.0 | 0.5 | GO:0000407 | pre-autophagosomal structure(GO:0000407) |
0.0 | 0.1 | GO:0070765 | gamma-secretase complex(GO:0070765) |
0.0 | 0.4 | GO:0005637 | nuclear inner membrane(GO:0005637) |
0.0 | 0.8 | GO:0005581 | collagen trimer(GO:0005581) |
0.0 | 0.6 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.0 | 3.9 | GO:0008142 | oxysterol binding(GO:0008142) |
0.8 | 3.0 | GO:0072320 | volume-sensitive chloride channel activity(GO:0072320) |
0.5 | 3.3 | GO:0019841 | retinol binding(GO:0019841) |
0.5 | 1.5 | GO:0031798 | type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052) |
0.4 | 2.1 | GO:1990190 | peptide-glutamate-N-acetyltransferase activity(GO:1990190) |
0.4 | 1.2 | GO:0070052 | collagen V binding(GO:0070052) |
0.3 | 7.1 | GO:0070410 | co-SMAD binding(GO:0070410) |
0.3 | 2.0 | GO:0046976 | histone methyltransferase activity (H3-K27 specific)(GO:0046976) |
0.2 | 1.0 | GO:0004032 | alditol:NADP+ 1-oxidoreductase activity(GO:0004032) |
0.2 | 1.0 | GO:0005127 | ciliary neurotrophic factor receptor binding(GO:0005127) |
0.2 | 0.7 | GO:0017077 | oxidative phosphorylation uncoupler activity(GO:0017077) |
0.2 | 0.7 | GO:0004921 | interleukin-11 receptor activity(GO:0004921) interleukin-11 binding(GO:0019970) |
0.2 | 1.5 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
0.2 | 1.1 | GO:0086006 | voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006) |
0.2 | 0.8 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
0.2 | 0.8 | GO:0034648 | histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648) |
0.1 | 0.4 | GO:0042284 | sphingolipid delta-4 desaturase activity(GO:0042284) |
0.1 | 0.5 | GO:0016971 | flavin-linked sulfhydryl oxidase activity(GO:0016971) |
0.1 | 0.7 | GO:0047134 | protein-disulfide reductase activity(GO:0047134) |
0.1 | 1.9 | GO:0030169 | low-density lipoprotein particle binding(GO:0030169) |
0.1 | 2.9 | GO:0003746 | translation elongation factor activity(GO:0003746) |
0.1 | 0.4 | GO:0005110 | frizzled-2 binding(GO:0005110) |
0.1 | 0.3 | GO:0036470 | tyrosine 3-monooxygenase activator activity(GO:0036470) L-dopa decarboxylase activator activity(GO:0036478) |
0.1 | 0.3 | GO:0005118 | sevenless binding(GO:0005118) |
0.1 | 0.5 | GO:0004719 | protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719) |
0.1 | 0.3 | GO:0004658 | propionyl-CoA carboxylase activity(GO:0004658) |
0.1 | 1.3 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
0.1 | 0.3 | GO:0008131 | primary amine oxidase activity(GO:0008131) |
0.1 | 7.1 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
0.1 | 0.8 | GO:0017176 | phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176) |
0.1 | 0.4 | GO:0000155 | phosphorelay sensor kinase activity(GO:0000155) |
0.1 | 0.2 | GO:0030284 | estrogen receptor activity(GO:0030284) |
0.1 | 0.3 | GO:0035515 | oxidative RNA demethylase activity(GO:0035515) |
0.1 | 0.2 | GO:0016314 | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314) |
0.1 | 0.3 | GO:0046923 | ER retention sequence binding(GO:0046923) |
0.1 | 1.0 | GO:0051861 | glycolipid binding(GO:0051861) |
0.1 | 0.7 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
0.1 | 0.5 | GO:0016618 | hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267) |
0.1 | 0.7 | GO:0005522 | profilin binding(GO:0005522) |
0.1 | 0.8 | GO:0003688 | DNA replication origin binding(GO:0003688) |
0.1 | 1.6 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
0.1 | 1.3 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
0.1 | 0.4 | GO:0008242 | omega peptidase activity(GO:0008242) |
0.1 | 1.0 | GO:0001222 | transcription corepressor binding(GO:0001222) |
0.1 | 0.5 | GO:0051434 | BH3 domain binding(GO:0051434) |
0.0 | 0.2 | GO:0070644 | vitamin D response element binding(GO:0070644) |
0.0 | 0.1 | GO:0098973 | structural constituent of synapse(GO:0098918) structural constituent of postsynaptic actin cytoskeleton(GO:0098973) |
0.0 | 0.2 | GO:0001165 | RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165) |
0.0 | 0.2 | GO:0008967 | phosphoglycolate phosphatase activity(GO:0008967) |
0.0 | 0.5 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
0.0 | 0.1 | GO:0046969 | histone deacetylase activity (H3-K9 specific)(GO:0032129) NAD-dependent histone deacetylase activity (H3-K9 specific)(GO:0046969) |
0.0 | 3.2 | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980) |
0.0 | 0.9 | GO:0017049 | GTP-Rho binding(GO:0017049) |
0.0 | 0.2 | GO:0005534 | galactose binding(GO:0005534) |
0.0 | 0.4 | GO:0047391 | alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391) |
0.0 | 0.6 | GO:0070034 | telomerase RNA binding(GO:0070034) |
0.0 | 1.3 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
0.0 | 0.3 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
0.0 | 0.9 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
0.0 | 0.6 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
0.0 | 0.6 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
0.0 | 1.3 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
0.0 | 0.7 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
0.0 | 0.8 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
0.0 | 0.2 | GO:1990948 | ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948) |
0.0 | 0.8 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
0.0 | 1.3 | GO:0005158 | insulin receptor binding(GO:0005158) |
0.0 | 0.5 | GO:0008143 | poly(A) binding(GO:0008143) |
0.0 | 0.2 | GO:0015114 | phosphate ion transmembrane transporter activity(GO:0015114) |
0.0 | 0.1 | GO:0046790 | virion binding(GO:0046790) |
0.0 | 0.6 | GO:0017134 | fibroblast growth factor binding(GO:0017134) |
0.0 | 0.2 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
0.0 | 0.3 | GO:0043495 | protein anchor(GO:0043495) |
0.0 | 2.4 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
0.0 | 0.1 | GO:0017108 | 5'-flap endonuclease activity(GO:0017108) |
0.0 | 0.1 | GO:0004045 | aminoacyl-tRNA hydrolase activity(GO:0004045) |
0.0 | 0.1 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
0.0 | 0.1 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
0.0 | 0.7 | GO:0005507 | copper ion binding(GO:0005507) |
0.0 | 0.2 | GO:0070411 | I-SMAD binding(GO:0070411) |
0.0 | 0.1 | GO:0042610 | CD8 receptor binding(GO:0042610) |
0.0 | 0.2 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
0.0 | 2.0 | GO:0042393 | histone binding(GO:0042393) |
0.0 | 0.0 | GO:0055056 | D-glucose transmembrane transporter activity(GO:0055056) |
0.0 | 0.1 | GO:0004792 | thiosulfate sulfurtransferase activity(GO:0004792) |
0.0 | 0.8 | GO:0019894 | kinesin binding(GO:0019894) |
0.0 | 9.4 | GO:0043565 | sequence-specific DNA binding(GO:0043565) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 7.1 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
0.1 | 1.6 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
0.1 | 2.0 | PID_INTEGRIN5_PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
0.1 | 10.5 | PID_SMAD2_3NUCLEAR_PATHWAY | Regulation of nuclear SMAD2/3 signaling |
0.1 | 2.6 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
0.1 | 2.1 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
0.1 | 1.5 | PID_FOXM1_PATHWAY | FOXM1 transcription factor network |
0.1 | 0.5 | SA_FAS_SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
0.0 | 1.4 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
0.0 | 0.4 | PID_INSULIN_GLUCOSE_PATHWAY | Insulin-mediated glucose transport |
0.0 | 1.8 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
0.0 | 1.0 | PID_GLYPICAN_1PATHWAY | Glypican 1 network |
0.0 | 1.2 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
0.0 | 1.4 | PID_HES_HEY_PATHWAY | Notch-mediated HES/HEY network |
0.0 | 2.2 | PID_AR_TF_PATHWAY | Regulation of Androgen receptor activity |
0.0 | 1.8 | PID_ILK_PATHWAY | Integrin-linked kinase signaling |
0.0 | 0.7 | ST_WNT_CA2_CYCLIC_GMP_PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
0.0 | 1.2 | ST_GAQ_PATHWAY | G alpha q Pathway |
0.0 | 0.6 | PID_ALPHA_SYNUCLEIN_PATHWAY | Alpha-synuclein signaling |
0.0 | 1.2 | PID_HDAC_CLASSI_PATHWAY | Signaling events mediated by HDAC Class I |
0.0 | 0.9 | PID_E2F_PATHWAY | E2F transcription factor network |
0.0 | 1.1 | PID_P53_REGULATION_PATHWAY | p53 pathway |
0.0 | 0.4 | SIG_IL4RECEPTOR_IN_B_LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
0.0 | 0.2 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
0.0 | 0.1 | PID_A6B1_A6B4_INTEGRIN_PATHWAY | a6b1 and a6b4 Integrin signaling |
0.0 | 0.9 | PID_RHOA_REG_PATHWAY | Regulation of RhoA activity |
0.0 | 0.2 | PID_BETA_CATENIN_DEG_PATHWAY | Degradation of beta catenin |
0.0 | 0.6 | WNT_SIGNALING | Genes related to Wnt-mediated signal transduction |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 8.1 | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
0.1 | 2.0 | REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
0.1 | 4.0 | REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA | Genes involved in G beta:gamma signalling through PLC beta |
0.1 | 1.8 | REACTOME_UNWINDING_OF_DNA | Genes involved in Unwinding of DNA |
0.1 | 2.8 | REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
0.1 | 3.2 | REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
0.1 | 2.4 | REACTOME_RNA_POL_I_TRANSCRIPTION_INITIATION | Genes involved in RNA Polymerase I Transcription Initiation |
0.1 | 1.2 | REACTOME_ACTIVATION_OF_RAC | Genes involved in Activation of Rac |
0.1 | 0.4 | REACTOME_PROSTACYCLIN_SIGNALLING_THROUGH_PROSTACYCLIN_RECEPTOR | Genes involved in Prostacyclin signalling through prostacyclin receptor |
0.1 | 0.9 | REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER | Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER |
0.1 | 3.9 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
0.0 | 0.7 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
0.0 | 0.6 | REACTOME_EXTENSION_OF_TELOMERES | Genes involved in Extension of Telomeres |
0.0 | 2.0 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
0.0 | 0.5 | REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION | Genes involved in FGFR1 ligand binding and activation |
0.0 | 1.0 | REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS | Genes involved in Regulation of Water Balance by Renal Aquaporins |
0.0 | 1.5 | REACTOME_GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
0.0 | 0.5 | REACTOME_MTORC1_MEDIATED_SIGNALLING | Genes involved in mTORC1-mediated signalling |
0.0 | 0.5 | REACTOME_INFLAMMASOMES | Genes involved in Inflammasomes |
0.0 | 0.8 | REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
0.0 | 0.8 | REACTOME_KINESINS | Genes involved in Kinesins |
0.0 | 0.7 | REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS | Genes involved in Regulation of gene expression in beta cells |
0.0 | 0.5 | REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI | Genes involved in RIP-mediated NFkB activation via DAI |
0.0 | 0.5 | REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
0.0 | 0.4 | REACTOME_SIGNAL_ATTENUATION | Genes involved in Signal attenuation |
0.0 | 1.0 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
0.0 | 3.2 | REACTOME_TRANSLATION | Genes involved in Translation |
0.0 | 0.3 | REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
0.0 | 1.1 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
0.0 | 0.6 | REACTOME_RECYCLING_PATHWAY_OF_L1 | Genes involved in Recycling pathway of L1 |
0.0 | 0.3 | REACTOME_CTLA4_INHIBITORY_SIGNALING | Genes involved in CTLA4 inhibitory signaling |
0.0 | 0.2 | REACTOME_G1_S_SPECIFIC_TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
0.0 | 0.7 | REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS | Genes involved in Trafficking of AMPA receptors |
0.0 | 0.2 | REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_GLUCAGON_LIKE_PEPTIDE1 | Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1 |
0.0 | 0.4 | REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
0.0 | 0.3 | REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
0.0 | 0.7 | REACTOME_CDK_MEDIATED_PHOSPHORYLATION_AND_REMOVAL_OF_CDC6 | Genes involved in CDK-mediated phosphorylation and removal of Cdc6 |
0.0 | 0.5 | REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT | Genes involved in Mitochondrial Protein Import |
0.0 | 0.9 | REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
0.0 | 0.4 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
0.0 | 0.2 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |