Motif ID: Trp53

Z-value: 1.276


Transcription factors associated with Trp53:

Gene SymbolEntrez IDGene Name
Trp53 ENSMUSG00000059552.7 Trp53

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Trp53mm10_v2_chr11_+_69580392_695804190.184.7e-01Click!


Activity profile for motif Trp53.

activity profile for motif Trp53


Sorted Z-values histogram for motif Trp53

Sorted Z-values for motif Trp53



Network of associatons between targets according to the STRING database.



First level regulatory network of Trp53

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_29090969 6.187 ENSMUST00000119901.1
Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr15_-_98004695 4.888 ENSMUST00000023123.8
Col2a1
collagen, type II, alpha 1
chr10_+_56377300 4.832 ENSMUST00000068581.7
Gja1
gap junction protein, alpha 1
chr15_-_98004634 4.467 ENSMUST00000131560.1
ENSMUST00000088355.5
Col2a1

collagen, type II, alpha 1

chr5_-_116422858 3.790 ENSMUST00000036991.4
Hspb8
heat shock protein 8
chr14_+_73237891 2.964 ENSMUST00000044405.6
Lpar6
lysophosphatidic acid receptor 6
chr9_+_45138437 2.905 ENSMUST00000060125.5
Scn4b
sodium channel, type IV, beta
chr2_-_69206146 2.860 ENSMUST00000127243.1
ENSMUST00000149643.1
ENSMUST00000167875.2
ENSMUST00000005365.8
Spc25



SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)



chr9_+_66946057 2.761 ENSMUST00000040917.7
ENSMUST00000127896.1
Rps27l

ribosomal protein S27-like

chr17_-_33890584 2.760 ENSMUST00000114361.2
ENSMUST00000173492.1
Kifc1

kinesin family member C1

chr14_-_34374617 2.635 ENSMUST00000023826.4
Sncg
synuclein, gamma
chr2_-_69206133 2.508 ENSMUST00000112320.1
Spc25
SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr1_+_6487231 2.483 ENSMUST00000140079.1
ENSMUST00000131494.1
St18

suppression of tumorigenicity 18

chr4_+_116596672 2.358 ENSMUST00000051869.7
Ccdc17
coiled-coil domain containing 17
chr4_-_135573623 2.351 ENSMUST00000105855.1
Grhl3
grainyhead-like 3 (Drosophila)
chr17_-_33890539 2.307 ENSMUST00000173386.1
Kifc1
kinesin family member C1
chr9_-_106158109 2.261 ENSMUST00000159809.1
ENSMUST00000162562.1
ENSMUST00000036382.6
ENSMUST00000112543.2
Glyctk



glycerate kinase



chr9_-_100486788 2.257 ENSMUST00000098458.3
Il20rb
interleukin 20 receptor beta
chr11_-_3527916 2.251 ENSMUST00000020718.4
Smtn
smoothelin
chr8_-_22185758 2.178 ENSMUST00000046916.7
Ckap2
cytoskeleton associated protein 2
chr17_+_87282880 2.046 ENSMUST00000041110.5
ENSMUST00000125875.1
Ttc7

tetratricopeptide repeat domain 7

chr5_-_30073554 1.984 ENSMUST00000026846.6
Tyms
thymidylate synthase
chr14_+_74735641 1.941 ENSMUST00000177283.1
Esd
esterase D/formylglutathione hydrolase
chr15_-_102350692 1.933 ENSMUST00000041208.7
Aaas
achalasia, adrenocortical insufficiency, alacrimia
chr11_-_17211504 1.915 ENSMUST00000020317.7
Pno1
partner of NOB1 homolog (S. cerevisiae)
chr17_+_35821675 1.823 ENSMUST00000003635.6
Ier3
immediate early response 3
chr14_+_47001336 1.799 ENSMUST00000125113.1
Samd4
sterile alpha motif domain containing 4
chr15_+_85859689 1.787 ENSMUST00000170629.1
Gtse1
G two S phase expressed protein 1
chr8_+_68880491 1.779 ENSMUST00000015712.8
Lpl
lipoprotein lipase
chr2_-_155074447 1.668 ENSMUST00000137242.1
ENSMUST00000054607.9
Ahcy

S-adenosylhomocysteine hydrolase

chr8_+_94977101 1.647 ENSMUST00000179619.1
Gpr56
G protein-coupled receptor 56
chr13_+_113317084 1.633 ENSMUST00000136755.2
BC067074
cDNA sequence BC067074
chr14_-_54926784 1.632 ENSMUST00000022813.6
Efs
embryonal Fyn-associated substrate
chr3_-_132950043 1.592 ENSMUST00000117164.1
ENSMUST00000093971.4
ENSMUST00000042729.9
ENSMUST00000042744.9
ENSMUST00000117811.1
Npnt




nephronectin




chr4_+_132351768 1.588 ENSMUST00000172202.1
Gm17300
predicted gene, 17300
chr4_-_43030440 1.576 ENSMUST00000135660.1
Stoml2
stomatin (Epb7.2)-like 2
chr10_-_81350191 1.492 ENSMUST00000122993.1
Hmg20b
high mobility group 20B
chr10_-_81350389 1.479 ENSMUST00000020454.4
ENSMUST00000105324.2
ENSMUST00000154609.2
ENSMUST00000105323.1
Hmg20b



high mobility group 20B



chr9_-_114982739 1.476 ENSMUST00000053150.5
Gm9846
predicted gene 9846
chr2_-_164857542 1.445 ENSMUST00000109316.1
ENSMUST00000156255.1
ENSMUST00000128110.1
ENSMUST00000109317.3
Pltp



phospholipid transfer protein



chr5_-_115194283 1.436 ENSMUST00000112113.1
Cabp1
calcium binding protein 1
chr10_+_93641041 1.393 ENSMUST00000020204.4
Ntn4
netrin 4
chr10_-_81350305 1.350 ENSMUST00000167481.1
Hmg20b
high mobility group 20B
chr7_+_24884809 1.338 ENSMUST00000156372.1
ENSMUST00000124035.1
Rps19

ribosomal protein S19

chr14_+_13454010 1.338 ENSMUST00000112656.2
Synpr
synaptoporin
chr4_-_9643638 1.245 ENSMUST00000108333.1
ENSMUST00000108334.1
ENSMUST00000108335.1
ENSMUST00000152526.1
ENSMUST00000103004.3
Asph




aspartate-beta-hydroxylase




chr11_-_93968293 1.215 ENSMUST00000170303.1
Gm20390
predicted gene 20390
chr4_+_115057683 1.212 ENSMUST00000161601.1
Tal1
T cell acute lymphocytic leukemia 1
chr16_+_20651652 1.206 ENSMUST00000007212.8
Psmd2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
chr7_-_114927726 1.187 ENSMUST00000059737.2
Gm6816
predicted gene 6816
chr4_+_115057410 1.185 ENSMUST00000136946.1
Tal1
T cell acute lymphocytic leukemia 1
chr7_-_98309471 1.170 ENSMUST00000033020.7
Acer3
alkaline ceramidase 3
chr16_-_59632520 1.163 ENSMUST00000118438.1
Arl6
ADP-ribosylation factor-like 6
chr7_-_64872993 1.141 ENSMUST00000094331.2
Ndnl2
necdin-like 2
chr11_+_17211912 1.139 ENSMUST00000046955.6
Wdr92
WD repeat domain 92
chr5_-_138272733 1.125 ENSMUST00000161665.1
ENSMUST00000100530.1
Gal3st4

galactose-3-O-sulfotransferase 4

chr11_-_93968242 1.125 ENSMUST00000107844.2
Nme1
NME/NM23 nucleoside diphosphate kinase 1
chr9_-_72985344 1.101 ENSMUST00000124565.2
Gm5918
predicted gene 5918
chr7_+_24884651 1.060 ENSMUST00000153451.2
ENSMUST00000108429.1
Rps19

ribosomal protein S19

chr14_-_55944536 1.039 ENSMUST00000022834.6
Cma1
chymase 1, mast cell
chr5_-_138272786 1.037 ENSMUST00000161279.1
ENSMUST00000161647.1
Gal3st4

galactose-3-O-sulfotransferase 4

chr18_+_66458587 1.036 ENSMUST00000025399.7
Pmaip1
phorbol-12-myristate-13-acetate-induced protein 1
chr7_+_24884611 1.032 ENSMUST00000108428.1
Rps19
ribosomal protein S19
chr2_+_59612034 1.029 ENSMUST00000112568.1
ENSMUST00000037526.4
Tanc1

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

chr6_-_136941494 0.958 ENSMUST00000111892.1
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr6_+_134981998 0.954 ENSMUST00000167323.1
Apold1
apolipoprotein L domain containing 1
chr8_-_84893887 0.950 ENSMUST00000003907.7
ENSMUST00000182458.1
ENSMUST00000109745.1
ENSMUST00000142748.1
Gcdh



glutaryl-Coenzyme A dehydrogenase



chr6_+_128438757 0.947 ENSMUST00000144745.1
Gm10069
predicted gene 10069
chr13_-_22035589 0.946 ENSMUST00000091742.4
Hist1h2ah
histone cluster 1, H2ah
chr12_+_59129720 0.941 ENSMUST00000175912.1
ENSMUST00000176892.1
Ctage5

CTAGE family, member 5

chr16_+_20717665 0.926 ENSMUST00000021405.7
Polr2h
polymerase (RNA) II (DNA directed) polypeptide H
chr11_-_102925086 0.921 ENSMUST00000021311.9
Kif18b
kinesin family member 18B
chr13_+_21754067 0.920 ENSMUST00000091709.2
Hist1h2bn
histone cluster 1, H2bn
chr18_+_61639542 0.910 ENSMUST00000183083.1
ENSMUST00000183087.1
Gm20748

predicted gene, 20748

chr15_+_83100281 0.906 ENSMUST00000167389.1
ENSMUST00000166427.1
Serhl

serine hydrolase-like

chr17_+_26917091 0.903 ENSMUST00000078961.4
Kifc5b
kinesin family member C5B
chrX_-_38635066 0.898 ENSMUST00000058265.7
C1galt1c1
C1GALT1-specific chaperone 1
chrX_+_74254782 0.890 ENSMUST00000119197.1
ENSMUST00000088313.4
Emd

emerin

chr12_+_59129757 0.858 ENSMUST00000069430.8
ENSMUST00000177370.1
Ctage5

CTAGE family, member 5

chr2_-_130664565 0.853 ENSMUST00000089559.4
Ddrgk1
DDRGK domain containing 1
chr5_+_114707760 0.850 ENSMUST00000094441.4
Tchp
trichoplein, keratin filament binding
chr3_-_28765364 0.825 ENSMUST00000094335.3
Gm6505
predicted pseudogene 6505
chr8_-_111854278 0.825 ENSMUST00000034432.5
Cfdp1
craniofacial development protein 1
chr2_-_155592567 0.816 ENSMUST00000155347.1
ENSMUST00000130881.1
ENSMUST00000079691.6
Gss


glutathione synthetase


chr7_+_64392645 0.793 ENSMUST00000037205.8
Mcee
methylmalonyl CoA epimerase
chr10_+_80622677 0.786 ENSMUST00000079773.6
Csnk1g2
casein kinase 1, gamma 2
chr15_+_83100201 0.769 ENSMUST00000078218.4
Serhl
serine hydrolase-like
chr6_-_136941694 0.748 ENSMUST00000032344.5
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr17_-_24696147 0.745 ENSMUST00000046839.8
Gfer
growth factor, erv1 (S. cerevisiae)-like (augmenter of liver regeneration)
chr11_+_88204396 0.743 ENSMUST00000118784.1
ENSMUST00000139170.1
ENSMUST00000107915.3
ENSMUST00000144070.1
Mrps23



mitochondrial ribosomal protein S23



chr15_-_77927728 0.730 ENSMUST00000174468.1
ENSMUST00000174529.1
ENSMUST00000173631.1
Txn2


thioredoxin 2


chr1_-_191907527 0.700 ENSMUST00000069573.5
1700034H15Rik
RIKEN cDNA 1700034H15 gene
chr1_+_161969179 0.649 ENSMUST00000111594.2
ENSMUST00000028021.6
Pigc

phosphatidylinositol glycan anchor biosynthesis, class C

chr2_+_29890063 0.632 ENSMUST00000028128.6
Odf2
outer dense fiber of sperm tails 2
chrX_-_37191160 0.632 ENSMUST00000016571.7
Ndufa1
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1
chr5_+_34989473 0.629 ENSMUST00000114284.1
ENSMUST00000114285.1
Rgs12

regulator of G-protein signaling 12

chr13_+_22035821 0.609 ENSMUST00000110455.2
Hist1h2bk
histone cluster 1, H2bk
chr14_+_13453937 0.536 ENSMUST00000153954.1
Synpr
synaptoporin
chr6_+_39592569 0.533 ENSMUST00000135671.1
ENSMUST00000119379.1
Ndufb2

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2

chr7_+_75455534 0.523 ENSMUST00000147005.1
ENSMUST00000166315.1
Akap13

A kinase (PRKA) anchor protein 13

chr9_+_38719024 0.522 ENSMUST00000129598.1
Vwa5a
von Willebrand factor A domain containing 5A
chr6_-_136941887 0.515 ENSMUST00000111891.1
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr14_-_70653081 0.497 ENSMUST00000062629.4
Npm2
nucleophosmin/nucleoplasmin 2
chr4_-_83285141 0.493 ENSMUST00000150522.1
Ttc39b
tetratricopeptide repeat domain 39B
chr11_+_52360824 0.489 ENSMUST00000102758.1
Vdac1
voltage-dependent anion channel 1
chr2_+_180078623 0.485 ENSMUST00000087563.6
Mtg2
mitochondrial ribosome associated GTPase 2
chr12_-_74316394 0.478 ENSMUST00000110441.1
Gm11042
predicted gene 11042
chr14_-_59365410 0.455 ENSMUST00000161031.1
ENSMUST00000160425.1
Phf11d

PHD finger protein 11D

chr9_+_72438534 0.453 ENSMUST00000034746.8
Mns1
meiosis-specific nuclear structural protein 1
chr3_-_19265007 0.434 ENSMUST00000091314.4
Pde7a
phosphodiesterase 7A
chr13_+_23574381 0.415 ENSMUST00000090776.4
Hist1h2ad
histone cluster 1, H2ad
chr1_-_65186456 0.401 ENSMUST00000169032.1
Idh1
isocitrate dehydrogenase 1 (NADP+), soluble
chr4_-_129641060 0.392 ENSMUST00000046425.9
ENSMUST00000133803.1
Txlna

taxilin alpha

chr17_-_34862473 0.388 ENSMUST00000025229.4
ENSMUST00000176203.2
ENSMUST00000128767.1
Cfb


complement factor B


chr9_+_65346066 0.347 ENSMUST00000048184.2
Pdcd7
programmed cell death 7
chr3_+_96172327 0.344 ENSMUST00000076372.4
Sf3b4
splicing factor 3b, subunit 4
chr1_+_82339049 0.343 ENSMUST00000140020.1
Rhbdd1
rhomboid domain containing 1
chr9_-_26999491 0.342 ENSMUST00000060513.7
ENSMUST00000120367.1
Acad8

acyl-Coenzyme A dehydrogenase family, member 8

chr9_-_21963568 0.330 ENSMUST00000006397.5
Epor
erythropoietin receptor
chr2_+_29889217 0.325 ENSMUST00000123335.1
Odf2
outer dense fiber of sperm tails 2
chr9_+_72438519 0.317 ENSMUST00000184604.1
Mns1
meiosis-specific nuclear structural protein 1
chr19_-_43524462 0.299 ENSMUST00000026196.7
Got1
glutamate oxaloacetate transaminase 1, soluble
chr1_+_88103229 0.281 ENSMUST00000113135.3
ENSMUST00000113138.1
Ugt1a6a
Ugt1a6b
UDP glucuronosyltransferase 1 family, polypeptide A6A
UDP glucuronosyltransferase 1 family, polypeptide A6B
chr11_-_98438941 0.280 ENSMUST00000002655.7
Mien1
migration and invasion enhancer 1
chr12_+_76255209 0.258 ENSMUST00000021443.5
Mthfd1
methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase
chr1_+_161969284 0.255 ENSMUST00000160881.1
ENSMUST00000159648.1
Pigc

phosphatidylinositol glycan anchor biosynthesis, class C

chr19_+_46328179 0.245 ENSMUST00000026256.2
ENSMUST00000177667.1
Fbxl15

F-box and leucine-rich repeat protein 15

chr7_-_103741322 0.224 ENSMUST00000051346.2
Olfr629
olfactory receptor 629
chr14_-_20496780 0.224 ENSMUST00000022353.3
Mss51
MSS51 mitochondrial translational activator
chr19_+_4097392 0.220 ENSMUST00000174514.1
ENSMUST00000174149.1
Cdk2ap2

CDK2-associated protein 2

chr19_-_4793851 0.208 ENSMUST00000178615.1
ENSMUST00000179189.1
ENSMUST00000164376.2
ENSMUST00000164209.2
ENSMUST00000180248.1
Rbm4




RNA binding motif protein 4




chr7_-_28962265 0.207 ENSMUST00000068045.7
Actn4
actinin alpha 4
chr3_+_90669063 0.192 ENSMUST00000069927.8
S100a8
S100 calcium binding protein A8 (calgranulin A)
chr8_+_9977707 0.191 ENSMUST00000139793.1
ENSMUST00000048216.5
Abhd13

abhydrolase domain containing 13

chr10_+_94550852 0.176 ENSMUST00000148910.1
ENSMUST00000117460.1
Tmcc3

transmembrane and coiled coil domains 3

chr2_+_10372426 0.171 ENSMUST00000114864.2
ENSMUST00000116594.2
ENSMUST00000041105.6
Sfmbt2


Scm-like with four mbt domains 2


chr5_+_34999046 0.156 ENSMUST00000114281.1
Rgs12
regulator of G-protein signaling 12
chr17_+_24840108 0.149 ENSMUST00000164251.1
Hagh
hydroxyacyl glutathione hydrolase
chr18_-_20002093 0.147 ENSMUST00000115848.3
Dsc3
desmocollin 3
chr12_-_81532840 0.146 ENSMUST00000166664.1
ENSMUST00000164386.1
ENSMUST00000169158.1
ENSMUST00000164431.1
ENSMUST00000163402.1
Gm20498

Synj2bp


predicted gene 20498

synaptojanin 2 binding protein


chr3_-_90389884 0.146 ENSMUST00000029541.5
Slc27a3
solute carrier family 27 (fatty acid transporter), member 3
chr1_-_184883218 0.134 ENSMUST00000048308.5
C130074G19Rik
RIKEN cDNA C130074G19 gene
chr10_+_110745433 0.134 ENSMUST00000174857.1
ENSMUST00000073781.5
ENSMUST00000173471.1
ENSMUST00000173634.1
E2f7



E2F transcription factor 7



chr5_-_38502107 0.121 ENSMUST00000005238.6
Slc2a9
solute carrier family 2 (facilitated glucose transporter), member 9
chr12_-_55492587 0.106 ENSMUST00000021413.7
Nfkbia
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
chr2_+_152962485 0.085 ENSMUST00000099197.2
ENSMUST00000103155.3
Ttll9

tubulin tyrosine ligase-like family, member 9

chr5_+_34999070 0.072 ENSMUST00000114280.1
Rgs12
regulator of G-protein signaling 12
chr5_-_38480131 0.062 ENSMUST00000143758.1
ENSMUST00000067886.5
Slc2a9

solute carrier family 2 (facilitated glucose transporter), member 9

chr13_-_23574196 0.056 ENSMUST00000105106.1
Hist1h2bf
histone cluster 1, H2bf
chr11_+_55469677 0.046 ENSMUST00000018727.3
G3bp1
GTPase activating protein (SH3 domain) binding protein 1
chr2_+_129100995 0.041 ENSMUST00000103205.4
ENSMUST00000028874.7
Polr1b

polymerase (RNA) I polypeptide B

chr3_-_19264959 0.034 ENSMUST00000121951.1
Pde7a
phosphodiesterase 7A
chr19_-_10604258 0.033 ENSMUST00000037678.6
Dak
dihydroxyacetone kinase 2 homolog (yeast)
chr2_+_72285637 0.023 ENSMUST00000090824.5
ENSMUST00000135469.1
Zak

sterile alpha motif and leucine zipper containing kinase AZK

chr4_-_155056784 0.017 ENSMUST00000131173.2
Plch2
phospholipase C, eta 2
chr2_+_112454997 0.015 ENSMUST00000069747.5
Emc7
ER membrane protein complex subunit 7
chr4_-_42084291 0.004 ENSMUST00000177937.1
Gm21968
predicted gene, 21968

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.1 GO:0072382 minus-end-directed vesicle transport along microtubule(GO:0072382)
1.6 4.8 GO:0003104 positive regulation of glomerular filtration(GO:0003104) cell communication by chemical coupling(GO:0010643)
0.9 3.4 GO:0060265 positive regulation of respiratory burst involved in inflammatory response(GO:0060265)
0.8 2.4 GO:0060217 hemangioblast cell differentiation(GO:0060217)
0.8 6.2 GO:0071493 cellular response to UV-B(GO:0071493)
0.8 2.3 GO:0002865 immune response-inhibiting signal transduction(GO:0002765) negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865)
0.7 8.7 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.5 1.6 GO:1990046 positive regulation of mitochondrial DNA replication(GO:0090297) regulation of cardiolipin metabolic process(GO:1900208) positive regulation of cardiolipin metabolic process(GO:1900210) stress-induced mitochondrial fusion(GO:1990046)
0.5 2.0 GO:0046073 dTMP biosynthetic process(GO:0006231) dTMP metabolic process(GO:0046073)
0.5 1.9 GO:0046294 formaldehyde catabolic process(GO:0046294)
0.4 1.8 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.4 1.2 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.4 2.2 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.4 1.4 GO:0042360 vitamin E metabolic process(GO:0042360)
0.3 1.2 GO:0046909 intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445)
0.3 4.3 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.3 1.4 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.3 1.6 GO:0010694 positive regulation of alkaline phosphatase activity(GO:0010694)
0.3 1.8 GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029)
0.2 2.5 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.2 1.7 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.2 2.5 GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization(GO:0060307)
0.2 2.4 GO:0061436 establishment of skin barrier(GO:0061436)
0.1 0.9 GO:0016266 O-glycan processing(GO:0016266)
0.1 0.9 GO:1990564 regulation of I-kappaB phosphorylation(GO:1903719) positive regulation of I-kappaB phosphorylation(GO:1903721) protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.1 2.8 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.1 3.0 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.1 0.4 GO:0006097 glyoxylate cycle(GO:0006097)
0.1 0.6 GO:0038032 termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.1 0.3 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.1 1.2 GO:0046512 sphingosine biosynthetic process(GO:0046512) sphingoid biosynthetic process(GO:0046520)
0.1 1.7 GO:0035337 fatty-acyl-CoA metabolic process(GO:0035337)
0.1 1.1 GO:0006228 UTP biosynthetic process(GO:0006228)
0.1 0.3 GO:0006106 fumarate metabolic process(GO:0006106) aspartate biosynthetic process(GO:0006532) aspartate catabolic process(GO:0006533) alditol biosynthetic process(GO:0019401)
0.1 2.6 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.1 0.5 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.1 0.3 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.1 0.8 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.1 1.0 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.1 0.7 GO:0097421 liver regeneration(GO:0097421)
0.1 1.8 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.1 0.9 GO:1902018 negative regulation of cilium assembly(GO:1902018)
0.1 0.4 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 0.3 GO:0006547 histidine metabolic process(GO:0006547)
0.1 0.2 GO:0070488 neutrophil aggregation(GO:0070488)
0.1 0.3 GO:0052695 cellular glucuronidation(GO:0052695)
0.1 0.7 GO:0006662 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.1 0.7 GO:0002227 innate immune response in mucosa(GO:0002227)
0.1 2.2 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.1 0.2 GO:1902396 protein localization to bicellular tight junction(GO:1902396)
0.1 5.4 GO:0007052 mitotic spindle organization(GO:0007052)
0.0 0.8 GO:0070986 left/right axis specification(GO:0070986)
0.0 0.9 GO:0007019 microtubule depolymerization(GO:0007019)
0.0 0.5 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.0 0.1 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
0.0 0.9 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.0 2.0 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.0 0.2 GO:0097167 circadian regulation of translation(GO:0097167)
0.0 1.0 GO:0097062 dendritic spine maintenance(GO:0097062)
0.0 0.5 GO:0006851 mitochondrial calcium ion transport(GO:0006851)
0.0 0.3 GO:0070234 positive regulation of T cell apoptotic process(GO:0070234)
0.0 0.3 GO:0061032 visceral serous pericardium development(GO:0061032)
0.0 1.2 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.2 GO:0046415 urate metabolic process(GO:0046415)
0.0 0.5 GO:0070129 regulation of mitochondrial translation(GO:0070129)
0.0 0.1 GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0 1.0 GO:0032611 interleukin-1 beta production(GO:0032611)
0.0 0.3 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.0 0.9 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 1.9 GO:0009566 fertilization(GO:0009566)
0.0 0.2 GO:2000035 regulation of stem cell division(GO:2000035)
0.0 1.0 GO:1902017 regulation of cilium assembly(GO:1902017)
0.0 0.1 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.0 0.3 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 1.4 GO:0006342 chromatin silencing(GO:0006342)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.2 GO:0070557 PCNA-p21 complex(GO:0070557)
1.1 4.3 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
0.9 5.4 GO:0031262 Ndc80 complex(GO:0031262)
0.8 2.4 GO:0033193 Lsd1/2 complex(GO:0033193)
0.8 9.4 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.4 4.8 GO:0005916 fascia adherens(GO:0005916)
0.3 1.6 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.3 6.0 GO:0031616 spindle pole centrosome(GO:0031616)
0.3 1.8 GO:0042627 chylomicron(GO:0042627)
0.2 1.2 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.2 2.9 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.2 0.9 GO:0000235 astral microtubule(GO:0000235)
0.1 0.9 GO:0045179 apical cortex(GO:0045179)
0.1 6.2 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 1.6 GO:0042101 T cell receptor complex(GO:0042101)
0.1 1.2 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540) cytosolic proteasome complex(GO:0031597)
0.1 1.9 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 4.0 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 1.0 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.1 0.9 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.5 GO:0046930 pore complex(GO:0046930)
0.0 0.3 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 1.2 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 2.5 GO:0032993 protein-DNA complex(GO:0032993)
0.0 1.2 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.7 GO:0015935 small ribosomal subunit(GO:0015935)
0.0 0.7 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.3 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 1.8 GO:0005604 basement membrane(GO:0005604)
0.0 1.2 GO:0000786 nucleosome(GO:0000786)
0.0 1.8 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.9 GO:0005871 kinesin complex(GO:0005871)
0.0 0.6 GO:0097440 apical dendrite(GO:0097440)
0.0 0.1 GO:0030057 desmosome(GO:0030057)
0.0 2.5 GO:0043679 axon terminus(GO:0043679)
0.0 1.3 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 2.0 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.9 GO:0005643 nuclear pore(GO:0005643)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.2 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
1.9 9.4 GO:0042289 MHC class II protein binding(GO:0042289)
1.2 4.8 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) gap junction channel activity involved in cell communication by electrical coupling(GO:1903763)
0.6 1.9 GO:0018738 S-formylglutathione hydrolase activity(GO:0018738)
0.5 2.8 GO:0008494 translation activator activity(GO:0008494)
0.4 3.0 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.4 2.9 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.4 5.1 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.4 2.2 GO:0050694 galactose 3-O-sulfotransferase activity(GO:0050694)
0.3 2.1 GO:0004920 interleukin-10 receptor activity(GO:0004920)
0.3 2.2 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.2 0.7 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.2 1.7 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.2 1.6 GO:1901612 phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)
0.2 1.2 GO:0017040 ceramidase activity(GO:0017040)
0.2 4.3 GO:0000400 four-way junction DNA binding(GO:0000400)
0.2 0.7 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.1 1.8 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 2.0 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.1 0.4 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.1 2.3 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.1 1.0 GO:0043237 laminin-1 binding(GO:0043237)
0.1 3.4 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.1 0.3 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.1 0.9 GO:0001055 RNA polymerase II activity(GO:0001055)
0.1 0.3 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.1 0.9 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.1 0.9 GO:0048531 beta-1,3-galactosyltransferase activity(GO:0048531)
0.1 2.6 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 1.3 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.1 0.5 GO:0015288 porin activity(GO:0015288)
0.1 1.8 GO:0030371 translation repressor activity(GO:0030371)
0.1 0.5 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.8 GO:0016594 glycine binding(GO:0016594)
0.0 2.4 GO:0070888 E-box binding(GO:0070888)
0.0 0.2 GO:0050544 arachidonic acid binding(GO:0050544)
0.0 0.2 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0 0.8 GO:0016854 racemase and epimerase activity(GO:0016854)
0.0 0.2 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.1 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.0 1.6 GO:0017124 SH3 domain binding(GO:0017124)
0.0 1.8 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.1 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 0.7 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.8 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 2.5 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 0.2 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.0 0.6 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 1.2 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.0 0.3 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.5 GO:0003924 GTPase activity(GO:0003924)
0.0 0.1 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.0 1.6 GO:0005178 integrin binding(GO:0005178)
0.0 1.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.1 GO:0045295 gamma-catenin binding(GO:0045295)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 6.2 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2 9.4 NABA_COLLAGENS Genes encoding collagen proteins
0.1 4.8 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 3.0 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 1.1 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 2.7 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 2.1 PID_E2F_PATHWAY E2F transcription factor network
0.0 0.4 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 1.0 PID_PLK1_PATHWAY PLK1 signaling events
0.0 0.2 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.8 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.4 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 4.8 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.3 3.0 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.2 6.2 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.2 9.4 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.2 5.1 REACTOME_KINESINS Genes involved in Kinesins
0.1 3.2 REACTOME_LIPOPROTEIN_METABOLISM Genes involved in Lipoprotein metabolism
0.1 2.0 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 2.0 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 0.4 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.1 1.0 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.1 3.4 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 1.9 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.1 2.0 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.1 0.9 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.1 5.1 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 1.1 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.8 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 2.0 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 4.3 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.8 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 0.9 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 1.4 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 1.2 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 1.2 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.9 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.3 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.0 1.2 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 0.2 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 2.7 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.3 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.4 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.3 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway