Motif ID: Hes5_Hes7
Z-value: 1.158


Transcription factors associated with Hes5_Hes7:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Hes5 | ENSMUSG00000048001.7 | Hes5 |
Hes7 | ENSMUSG00000023781.2 | Hes7 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Hes5 | mm10_v2_chr4_+_154960915_154960930 | 0.78 | 1.3e-04 | Click! |
Hes7 | mm10_v2_chr11_+_69120404_69120404 | -0.40 | 1.0e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
3.4 | 30.4 | GO:0070874 | negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874) |
1.2 | 3.6 | GO:0021529 | spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) musculoskeletal movement, spinal reflex action(GO:0050883) olfactory pit development(GO:0060166) |
1.1 | 3.4 | GO:0021759 | globus pallidus development(GO:0021759) |
0.6 | 1.9 | GO:0010814 | substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959) |
0.3 | 1.0 | GO:0060167 | regulation of adenosine receptor signaling pathway(GO:0060167) regulation of G-protein coupled receptor internalization(GO:1904020) |
0.3 | 2.5 | GO:0043951 | negative regulation of cAMP-mediated signaling(GO:0043951) |
0.3 | 2.1 | GO:0006685 | sphingomyelin catabolic process(GO:0006685) |
0.2 | 2.2 | GO:0042095 | interferon-gamma biosynthetic process(GO:0042095) |
0.2 | 0.6 | GO:0015772 | disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772) |
0.2 | 0.8 | GO:0010636 | positive regulation of mitochondrial fusion(GO:0010636) |
0.2 | 1.3 | GO:0038031 | non-canonical Wnt signaling pathway via JNK cascade(GO:0038031) |
0.1 | 1.2 | GO:0006975 | DNA damage induced protein phosphorylation(GO:0006975) |
0.1 | 0.5 | GO:1903416 | response to glycoside(GO:1903416) |
0.1 | 0.6 | GO:0060066 | oviduct development(GO:0060066) |
0.1 | 0.5 | GO:0015744 | succinate transport(GO:0015744) |
0.1 | 0.4 | GO:0009174 | UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049) |
0.1 | 1.3 | GO:0033690 | positive regulation of osteoblast proliferation(GO:0033690) |
0.1 | 0.3 | GO:1903334 | positive regulation of protein folding(GO:1903334) |
0.1 | 2.3 | GO:0045780 | positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852) |
0.1 | 1.6 | GO:0043567 | regulation of insulin-like growth factor receptor signaling pathway(GO:0043567) |
0.1 | 1.0 | GO:0000244 | spliceosomal tri-snRNP complex assembly(GO:0000244) |
0.1 | 0.8 | GO:0035873 | lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879) |
0.1 | 0.4 | GO:0006344 | maintenance of chromatin silencing(GO:0006344) |
0.1 | 0.6 | GO:0007000 | nucleolus organization(GO:0007000) |
0.1 | 1.4 | GO:0032331 | negative regulation of chondrocyte differentiation(GO:0032331) |
0.1 | 2.1 | GO:0030513 | positive regulation of BMP signaling pathway(GO:0030513) |
0.0 | 0.6 | GO:0090557 | establishment of endothelial intestinal barrier(GO:0090557) |
0.0 | 0.2 | GO:0010991 | negative regulation of SMAD protein complex assembly(GO:0010991) |
0.0 | 0.3 | GO:0048842 | positive regulation of axon extension involved in axon guidance(GO:0048842) |
0.0 | 0.3 | GO:0007016 | cytoskeletal anchoring at plasma membrane(GO:0007016) |
0.0 | 0.3 | GO:0061484 | hematopoietic stem cell homeostasis(GO:0061484) |
0.0 | 0.1 | GO:0070944 | neutrophil mediated killing of bacterium(GO:0070944) |
0.0 | 2.0 | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) |
0.0 | 0.6 | GO:0008535 | cellular copper ion homeostasis(GO:0006878) respiratory chain complex IV assembly(GO:0008535) |
0.0 | 0.1 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
0.0 | 3.1 | GO:0030177 | positive regulation of Wnt signaling pathway(GO:0030177) |
0.0 | 0.7 | GO:0050850 | positive regulation of calcium-mediated signaling(GO:0050850) |
0.0 | 0.1 | GO:0032380 | regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383) |
0.0 | 0.2 | GO:0051292 | nuclear pore complex assembly(GO:0051292) |
0.0 | 0.1 | GO:1903755 | regulation of SUMO transferase activity(GO:1903182) positive regulation of SUMO transferase activity(GO:1903755) |
0.0 | 0.1 | GO:0009098 | branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099) |
0.0 | 0.2 | GO:0007250 | activation of NF-kappaB-inducing kinase activity(GO:0007250) |
0.0 | 0.2 | GO:0043248 | proteasome assembly(GO:0043248) |
0.0 | 0.7 | GO:0048488 | synaptic vesicle endocytosis(GO:0048488) |
0.0 | 1.3 | GO:0030326 | embryonic limb morphogenesis(GO:0030326) embryonic appendage morphogenesis(GO:0035113) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 1.9 | GO:0033093 | Weibel-Palade body(GO:0033093) |
0.1 | 0.5 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
0.1 | 0.6 | GO:0046581 | intercellular canaliculus(GO:0046581) |
0.1 | 0.7 | GO:0044233 | ER-mitochondrion membrane contact site(GO:0044233) |
0.1 | 0.2 | GO:0097135 | cyclin E2-CDK2 complex(GO:0097135) |
0.1 | 0.6 | GO:0070545 | PeBoW complex(GO:0070545) |
0.1 | 0.6 | GO:0016600 | flotillin complex(GO:0016600) |
0.0 | 0.2 | GO:0044611 | nuclear pore inner ring(GO:0044611) |
0.0 | 0.8 | GO:0005652 | nuclear lamina(GO:0005652) |
0.0 | 1.0 | GO:0046540 | U4/U6 x U5 tri-snRNP complex(GO:0046540) |
0.0 | 0.3 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
0.0 | 3.6 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
0.0 | 0.4 | GO:0071564 | npBAF complex(GO:0071564) |
0.0 | 0.3 | GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506) |
0.0 | 0.1 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
0.0 | 1.3 | GO:0005581 | collagen trimer(GO:0005581) |
0.0 | 0.1 | GO:1990356 | sumoylated E2 ligase complex(GO:1990356) |
0.0 | 2.1 | GO:0031225 | anchored component of membrane(GO:0031225) |
0.0 | 1.3 | GO:0005657 | replication fork(GO:0005657) |
0.0 | 0.2 | GO:0036038 | MKS complex(GO:0036038) |
0.0 | 2.9 | GO:0005667 | transcription factor complex(GO:0005667) |
0.0 | 2.3 | GO:0009897 | external side of plasma membrane(GO:0009897) |
0.0 | 1.1 | GO:0000118 | histone deacetylase complex(GO:0000118) |
0.0 | 0.1 | GO:0090543 | Flemming body(GO:0090543) |
0.0 | 0.1 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
0.0 | 3.4 | GO:0016607 | nuclear speck(GO:0016607) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.8 | 30.4 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
0.4 | 1.2 | GO:0035402 | histone kinase activity (H3-T11 specific)(GO:0035402) |
0.3 | 1.4 | GO:0008422 | beta-glucosidase activity(GO:0008422) |
0.3 | 3.4 | GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) |
0.3 | 2.1 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
0.2 | 1.0 | GO:0031687 | A2A adenosine receptor binding(GO:0031687) |
0.2 | 1.6 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
0.2 | 0.6 | GO:0008515 | sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157) |
0.2 | 0.5 | GO:0015140 | malate transmembrane transporter activity(GO:0015140) |
0.1 | 0.8 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
0.1 | 0.3 | GO:0035373 | chondroitin sulfate proteoglycan binding(GO:0035373) |
0.1 | 2.6 | GO:0017147 | Wnt-protein binding(GO:0017147) |
0.1 | 3.7 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
0.1 | 0.6 | GO:0071253 | connexin binding(GO:0071253) |
0.1 | 0.5 | GO:1990239 | steroid hormone binding(GO:1990239) |
0.1 | 2.5 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650) |
0.0 | 0.6 | GO:0045294 | alpha-catenin binding(GO:0045294) |
0.0 | 1.4 | GO:0005109 | frizzled binding(GO:0005109) |
0.0 | 0.3 | GO:0030274 | LIM domain binding(GO:0030274) |
0.0 | 0.2 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
0.0 | 0.7 | GO:0034185 | apolipoprotein binding(GO:0034185) |
0.0 | 0.3 | GO:0015037 | peptide disulfide oxidoreductase activity(GO:0015037) |
0.0 | 0.3 | GO:0031996 | thioesterase binding(GO:0031996) |
0.0 | 1.7 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
0.0 | 0.4 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
0.0 | 0.8 | GO:0004521 | endoribonuclease activity(GO:0004521) |
0.0 | 0.1 | GO:0052654 | branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656) |
0.0 | 1.2 | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981) |
0.0 | 0.2 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 30.4 | PID_IGF1_PATHWAY | IGF1 pathway |
0.1 | 1.2 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
0.1 | 5.7 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
0.1 | 2.6 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
0.1 | 2.2 | PID_P38_MKK3_6PATHWAY | p38 MAPK signaling pathway |
0.1 | 3.6 | PID_HES_HEY_PATHWAY | Notch-mediated HES/HEY network |
0.0 | 1.0 | PID_NECTIN_PATHWAY | Nectin adhesion pathway |
0.0 | 0.2 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
0.0 | 0.6 | PID_ECADHERIN_NASCENT_AJ_PATHWAY | E-cadherin signaling in the nascent adherens junction |
0.0 | 2.1 | PID_MYC_ACTIV_PATHWAY | Validated targets of C-MYC transcriptional activation |
0.0 | 1.4 | WNT_SIGNALING | Genes related to Wnt-mediated signal transduction |
0.0 | 0.3 | PID_SMAD2_3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
0.0 | 1.6 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.4 | 30.4 | REACTOME_SIGNAL_ATTENUATION | Genes involved in Signal attenuation |
0.2 | 1.2 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
0.1 | 1.2 | REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
0.1 | 1.6 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
0.1 | 0.8 | REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
0.1 | 2.3 | REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
0.1 | 0.7 | REACTOME_CALNEXIN_CALRETICULIN_CYCLE | Genes involved in Calnexin/calreticulin cycle |
0.0 | 0.6 | REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
0.0 | 2.7 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
0.0 | 0.3 | REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ | Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins |
0.0 | 0.2 | REACTOME_P53_DEPENDENT_G1_DNA_DAMAGE_RESPONSE | Genes involved in p53-Dependent G1 DNA Damage Response |
0.0 | 0.5 | REACTOME_SULFUR_AMINO_ACID_METABOLISM | Genes involved in Sulfur amino acid metabolism |
0.0 | 3.1 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
0.0 | 0.4 | REACTOME_PYRIMIDINE_METABOLISM | Genes involved in Pyrimidine metabolism |
0.0 | 0.5 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
0.0 | 0.2 | REACTOME_REGULATION_OF_AMPK_ACTIVITY_VIA_LKB1 | Genes involved in Regulation of AMPK activity via LKB1 |
0.0 | 0.3 | REACTOME_OTHER_SEMAPHORIN_INTERACTIONS | Genes involved in Other semaphorin interactions |