Motif ID: Prdm1
Z-value: 0.845

Transcription factors associated with Prdm1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Prdm1 | ENSMUSG00000038151.6 | Prdm1 |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 1.1 | GO:0006001 | fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) glycolytic process through fructose-1-phosphate(GO:0061625) |
0.2 | 0.7 | GO:0006553 | lysine metabolic process(GO:0006553) |
0.2 | 0.6 | GO:0060126 | somatotropin secreting cell differentiation(GO:0060126) |
0.2 | 0.5 | GO:0097026 | dendritic cell dendrite assembly(GO:0097026) |
0.2 | 0.5 | GO:1904139 | microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139) |
0.1 | 0.6 | GO:1903237 | negative regulation of leukocyte tethering or rolling(GO:1903237) |
0.1 | 1.0 | GO:0090336 | positive regulation of brown fat cell differentiation(GO:0090336) |
0.1 | 0.3 | GO:0002578 | negative regulation of antigen processing and presentation(GO:0002578) |
0.1 | 0.5 | GO:0060266 | negative regulation of respiratory burst involved in inflammatory response(GO:0060266) |
0.1 | 0.3 | GO:0032701 | negative regulation of interleukin-18 production(GO:0032701) |
0.1 | 0.3 | GO:0045349 | interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) |
0.1 | 0.6 | GO:0044838 | cell quiescence(GO:0044838) |
0.1 | 1.4 | GO:0021684 | cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707) |
0.1 | 0.4 | GO:0021984 | adenohypophysis development(GO:0021984) |
0.1 | 0.3 | GO:0015817 | glutamine transport(GO:0006868) histidine transport(GO:0015817) cellular response to potassium ion starvation(GO:0051365) |
0.1 | 0.8 | GO:0016926 | protein desumoylation(GO:0016926) |
0.1 | 0.3 | GO:0010701 | positive regulation of norepinephrine secretion(GO:0010701) |
0.1 | 0.2 | GO:0043181 | vacuolar sequestering(GO:0043181) |
0.1 | 0.4 | GO:0060594 | mammary gland specification(GO:0060594) |
0.1 | 0.5 | GO:0019885 | antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885) |
0.1 | 0.2 | GO:0090238 | positive regulation of arachidonic acid secretion(GO:0090238) |
0.1 | 0.2 | GO:0061762 | CAMKK-AMPK signaling cascade(GO:0061762) |
0.0 | 0.3 | GO:0010908 | regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) |
0.0 | 0.4 | GO:0030432 | peristalsis(GO:0030432) |
0.0 | 0.3 | GO:0021555 | midbrain-hindbrain boundary morphogenesis(GO:0021555) |
0.0 | 0.2 | GO:0009794 | regulation of mitotic cell cycle, embryonic(GO:0009794) mitotic cell cycle, embryonic(GO:0045448) |
0.0 | 1.7 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
0.0 | 0.4 | GO:0042760 | very long-chain fatty acid catabolic process(GO:0042760) |
0.0 | 0.1 | GO:0046077 | dUDP biosynthetic process(GO:0006227) pyrimidine nucleoside diphosphate metabolic process(GO:0009138) pyrimidine nucleoside diphosphate biosynthetic process(GO:0009139) pyrimidine deoxyribonucleoside diphosphate metabolic process(GO:0009196) pyrimidine deoxyribonucleoside diphosphate biosynthetic process(GO:0009197) dUDP metabolic process(GO:0046077) |
0.0 | 0.3 | GO:0043383 | negative T cell selection(GO:0043383) negative thymic T cell selection(GO:0045060) |
0.0 | 0.2 | GO:1903416 | response to glycoside(GO:1903416) |
0.0 | 0.2 | GO:0090370 | negative regulation of cholesterol efflux(GO:0090370) |
0.0 | 0.3 | GO:0043553 | negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) |
0.0 | 0.5 | GO:0070842 | aggresome assembly(GO:0070842) |
0.0 | 0.3 | GO:0061009 | common bile duct development(GO:0061009) |
0.0 | 0.2 | GO:1904659 | glucose transmembrane transport(GO:1904659) |
0.0 | 0.5 | GO:0021902 | commitment of neuronal cell to specific neuron type in forebrain(GO:0021902) |
0.0 | 0.3 | GO:0019243 | methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727) |
0.0 | 0.2 | GO:0006689 | ganglioside catabolic process(GO:0006689) oligosaccharide catabolic process(GO:0009313) |
0.0 | 0.4 | GO:0014842 | regulation of skeletal muscle satellite cell proliferation(GO:0014842) |
0.0 | 0.1 | GO:0034198 | cellular response to amino acid starvation(GO:0034198) |
0.0 | 0.1 | GO:0001803 | type III hypersensitivity(GO:0001802) regulation of type III hypersensitivity(GO:0001803) positive regulation of type III hypersensitivity(GO:0001805) serotonin secretion by platelet(GO:0002554) |
0.0 | 0.2 | GO:0006451 | selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451) |
0.0 | 0.7 | GO:0010172 | embryonic body morphogenesis(GO:0010172) |
0.0 | 0.2 | GO:0071907 | determination of digestive tract left/right asymmetry(GO:0071907) |
0.0 | 0.1 | GO:0043569 | negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569) |
0.0 | 0.4 | GO:0071577 | zinc II ion transmembrane transport(GO:0071577) |
0.0 | 0.1 | GO:0051013 | microtubule severing(GO:0051013) |
0.0 | 0.1 | GO:0035616 | histone H2B conserved C-terminal lysine deubiquitination(GO:0035616) |
0.0 | 0.1 | GO:0070212 | protein poly-ADP-ribosylation(GO:0070212) |
0.0 | 0.2 | GO:0046826 | negative regulation of protein export from nucleus(GO:0046826) protein K6-linked ubiquitination(GO:0085020) |
0.0 | 0.1 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
0.0 | 0.2 | GO:0046459 | short-chain fatty acid metabolic process(GO:0046459) |
0.0 | 0.1 | GO:2001181 | positive regulation of interleukin-10 secretion(GO:2001181) |
0.0 | 0.1 | GO:0002317 | plasma cell differentiation(GO:0002317) |
0.0 | 0.1 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
0.0 | 0.3 | GO:0032463 | negative regulation of protein homooligomerization(GO:0032463) |
0.0 | 0.1 | GO:0045716 | positive regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045716) |
0.0 | 0.2 | GO:0010818 | T cell chemotaxis(GO:0010818) |
0.0 | 0.1 | GO:0097343 | ripoptosome assembly(GO:0097343) ripoptosome assembly involved in necroptotic process(GO:1901026) |
0.0 | 0.1 | GO:0070294 | renal sodium ion absorption(GO:0070294) |
0.0 | 0.3 | GO:0007340 | acrosome reaction(GO:0007340) |
0.0 | 0.3 | GO:1900027 | regulation of ruffle assembly(GO:1900027) |
0.0 | 0.1 | GO:1990403 | embryonic brain development(GO:1990403) |
0.0 | 0.2 | GO:2001275 | positive regulation of glucose import in response to insulin stimulus(GO:2001275) |
0.0 | 0.1 | GO:0045065 | cytotoxic T cell differentiation(GO:0045065) |
0.0 | 0.1 | GO:0060050 | positive regulation of protein glycosylation(GO:0060050) spindle assembly involved in meiosis(GO:0090306) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 0.5 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
0.1 | 0.2 | GO:0032280 | symmetric synapse(GO:0032280) |
0.0 | 0.2 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
0.0 | 0.4 | GO:0035749 | myelin sheath adaxonal region(GO:0035749) |
0.0 | 0.0 | GO:0071438 | invadopodium membrane(GO:0071438) |
0.0 | 0.3 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) |
0.0 | 0.2 | GO:0042825 | TAP complex(GO:0042825) |
0.0 | 0.2 | GO:0070531 | BRCA1-A complex(GO:0070531) |
0.0 | 0.2 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
0.0 | 1.0 | GO:0016235 | aggresome(GO:0016235) |
0.0 | 1.0 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
0.0 | 0.3 | GO:0036038 | MKS complex(GO:0036038) |
0.0 | 0.1 | GO:0048476 | Holliday junction resolvase complex(GO:0048476) |
0.0 | 0.3 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 1.1 | GO:0004454 | ketohexokinase activity(GO:0004454) |
0.2 | 0.6 | GO:0098770 | FBXO family protein binding(GO:0098770) |
0.2 | 0.6 | GO:1990050 | phosphatidic acid transporter activity(GO:1990050) |
0.2 | 0.7 | GO:0016647 | oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647) |
0.1 | 0.4 | GO:0001602 | pancreatic polypeptide receptor activity(GO:0001602) |
0.1 | 0.3 | GO:0015182 | L-asparagine transmembrane transporter activity(GO:0015182) |
0.1 | 0.3 | GO:0036313 | phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313) |
0.1 | 0.3 | GO:0016160 | alpha-amylase activity(GO:0004556) amylase activity(GO:0016160) |
0.1 | 0.8 | GO:0016929 | SUMO-specific protease activity(GO:0016929) |
0.1 | 0.2 | GO:0031735 | CCR10 chemokine receptor binding(GO:0031735) |
0.1 | 0.3 | GO:0000405 | bubble DNA binding(GO:0000405) |
0.1 | 0.6 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
0.1 | 0.2 | GO:0004574 | oligo-1,6-glucosidase activity(GO:0004574) |
0.0 | 0.2 | GO:0070051 | fibrinogen binding(GO:0070051) |
0.0 | 0.3 | GO:0005138 | interleukin-6 receptor binding(GO:0005138) |
0.0 | 0.1 | GO:0009041 | uridylate kinase activity(GO:0009041) |
0.0 | 0.3 | GO:0004416 | hydroxyacylglutathione hydrolase activity(GO:0004416) |
0.0 | 0.2 | GO:0046978 | TAP1 binding(GO:0046978) TAP2 binding(GO:0046979) |
0.0 | 0.1 | GO:0072345 | NAADP-sensitive calcium-release channel activity(GO:0072345) |
0.0 | 0.6 | GO:0008009 | chemokine activity(GO:0008009) |
0.0 | 0.2 | GO:0035174 | histone serine kinase activity(GO:0035174) |
0.0 | 0.1 | GO:0042834 | peptidoglycan binding(GO:0042834) |
0.0 | 0.6 | GO:0070628 | proteasome binding(GO:0070628) |
0.0 | 0.6 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
0.0 | 0.1 | GO:0050347 | trans-hexaprenyltranstransferase activity(GO:0000010) trans-octaprenyltranstransferase activity(GO:0050347) |
0.0 | 0.3 | GO:0015271 | outward rectifier potassium channel activity(GO:0015271) |
0.0 | 0.4 | GO:0016290 | palmitoyl-CoA hydrolase activity(GO:0016290) |
0.0 | 0.3 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
0.0 | 0.1 | GO:0019863 | IgE binding(GO:0019863) |
0.0 | 0.3 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
0.0 | 0.2 | GO:0035497 | cAMP response element binding(GO:0035497) |
0.0 | 0.2 | GO:1990239 | steroid hormone binding(GO:1990239) |
0.0 | 0.1 | GO:0008568 | microtubule-severing ATPase activity(GO:0008568) |
0.0 | 0.3 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) mitogen-activated protein kinase p38 binding(GO:0048273) |
0.0 | 0.3 | GO:0070016 | gamma-catenin binding(GO:0045295) armadillo repeat domain binding(GO:0070016) |
0.0 | 0.4 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
0.0 | 0.4 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
0.0 | 0.0 | GO:0008823 | cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851) |
0.0 | 0.2 | GO:0008188 | neuropeptide receptor activity(GO:0008188) |
0.0 | 0.4 | GO:0071837 | HMG box domain binding(GO:0071837) |
0.0 | 0.0 | GO:0030171 | voltage-gated proton channel activity(GO:0030171) |
0.0 | 0.9 | GO:0098811 | transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811) |
0.0 | 0.2 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
0.0 | 0.2 | GO:0004559 | alpha-mannosidase activity(GO:0004559) |
0.0 | 0.2 | GO:0005355 | glucose transmembrane transporter activity(GO:0005355) |
0.0 | 0.2 | GO:0003995 | acyl-CoA dehydrogenase activity(GO:0003995) |
0.0 | 0.6 | GO:0016836 | hydro-lyase activity(GO:0016836) |
0.0 | 0.1 | GO:0031730 | CCR5 chemokine receptor binding(GO:0031730) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 0.5 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
0.0 | 0.6 | PID_SYNDECAN_4_PATHWAY | Syndecan-4-mediated signaling events |
0.0 | 0.2 | PID_INTEGRIN_CS_PATHWAY | Integrin family cell surface interactions |
0.0 | 0.3 | PID_SYNDECAN_2_PATHWAY | Syndecan-2-mediated signaling events |
0.0 | 0.6 | PID_IL2_STAT5_PATHWAY | IL2 signaling events mediated by STAT5 |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 1.0 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
0.0 | 0.2 | REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION_IN_TLR7_8_OR_9_SIGNALING | Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling |
0.0 | 0.3 | REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
0.0 | 0.2 | REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
0.0 | 0.2 | REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
0.0 | 0.3 | REACTOME_HS_GAG_DEGRADATION | Genes involved in HS-GAG degradation |
0.0 | 0.6 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
0.0 | 0.2 | REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
0.0 | 0.2 | REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
0.0 | 0.6 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
0.0 | 0.3 | REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |