Motif ID: Tfap2e

Z-value: 0.816


Transcription factors associated with Tfap2e:

Gene SymbolEntrez IDGene Name
Tfap2e ENSMUSG00000042477.7 Tfap2e

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap2emm10_v2_chr4_-_126736236_126736245-0.626.2e-03Click!


Activity profile for motif Tfap2e.

activity profile for motif Tfap2e


Sorted Z-values histogram for motif Tfap2e

Sorted Z-values for motif Tfap2e



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap2e

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_91945703 5.706 ENSMUST00000178895.1
Gm9821
predicted gene 9821
chr11_-_102897123 3.547 ENSMUST00000067444.3
Gfap
glial fibrillary acidic protein
chr6_+_108213086 3.484 ENSMUST00000032192.6
Itpr1
inositol 1,4,5-trisphosphate receptor 1
chr1_+_159737510 2.820 ENSMUST00000111669.3
Tnr
tenascin R
chr13_+_54949388 1.920 ENSMUST00000026994.7
ENSMUST00000109994.2
Unc5a

unc-5 homolog A (C. elegans)

chr11_-_102897146 1.833 ENSMUST00000077902.4
Gfap
glial fibrillary acidic protein
chr13_-_101768154 1.572 ENSMUST00000055518.6
Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr8_+_41239718 1.304 ENSMUST00000045218.7
Pcm1
pericentriolar material 1
chr6_-_137649211 1.159 ENSMUST00000134630.1
ENSMUST00000058210.6
ENSMUST00000111878.1
Eps8


epidermal growth factor receptor pathway substrate 8


chr15_-_102524615 1.135 ENSMUST00000023814.7
Npff
neuropeptide FF-amide peptide precursor
chr16_+_93832121 1.099 ENSMUST00000044068.6
Morc3
microrchidia 3
chr12_+_109544498 1.031 ENSMUST00000126289.1
Meg3
maternally expressed 3
chr15_-_58214882 1.021 ENSMUST00000022986.6
Fbxo32
F-box protein 32
chr8_+_107293500 1.020 ENSMUST00000151114.1
ENSMUST00000075922.4
ENSMUST00000125721.1
Nfat5


nuclear factor of activated T cells 5


chr8_+_94152607 1.008 ENSMUST00000034211.8
Mt3
metallothionein 3
chr8_+_107293463 0.974 ENSMUST00000169453.1
Nfat5
nuclear factor of activated T cells 5
chr6_-_39725193 0.962 ENSMUST00000101497.3
Braf
Braf transforming gene
chr6_-_39725448 0.948 ENSMUST00000002487.8
Braf
Braf transforming gene
chr17_+_37046555 0.945 ENSMUST00000172789.1
Gabbr1
gamma-aminobutyric acid (GABA) B receptor, 1
chr2_+_55437100 0.934 ENSMUST00000112633.2
ENSMUST00000112632.1
Kcnj3

potassium inwardly-rectifying channel, subfamily J, member 3

chr7_-_45333754 0.906 ENSMUST00000042194.8
Trpm4
transient receptor potential cation channel, subfamily M, member 4
chr9_-_97111117 0.868 ENSMUST00000085206.4
Slc25a36
solute carrier family 25, member 36
chr3_-_113630068 0.861 ENSMUST00000092154.3
ENSMUST00000106536.1
ENSMUST00000106535.1
Rnpc3


RNA-binding region (RNP1, RRM) containing 3


chr5_-_34187670 0.850 ENSMUST00000042701.6
ENSMUST00000119171.1
Mxd4

Max dimerization protein 4

chr9_+_100643755 0.808 ENSMUST00000133388.1
Stag1
stromal antigen 1
chr6_-_97617536 0.800 ENSMUST00000113355.2
Frmd4b
FERM domain containing 4B
chr9_+_100643605 0.782 ENSMUST00000041418.6
Stag1
stromal antigen 1
chr9_+_100643448 0.766 ENSMUST00000146312.1
ENSMUST00000129269.1
Stag1

stromal antigen 1

chr9_+_109931774 0.742 ENSMUST00000169851.2
Map4
microtubule-associated protein 4
chr4_+_151089570 0.730 ENSMUST00000105667.2
Gm13090
predicted gene 13090
chrX_-_43167817 0.706 ENSMUST00000115058.1
ENSMUST00000115059.1
Tenm1

teneurin transmembrane protein 1

chr13_-_111490111 0.635 ENSMUST00000047627.7
Gpbp1
GC-rich promoter binding protein 1
chr7_-_19629355 0.630 ENSMUST00000049912.8
ENSMUST00000094762.3
ENSMUST00000098754.4
Relb


avian reticuloendotheliosis viral (v-rel) oncogene related B


chr13_-_111490028 0.608 ENSMUST00000091236.4
Gpbp1
GC-rich promoter binding protein 1
chr4_+_42158092 0.563 ENSMUST00000098122.2
Gm13306
predicted gene 13306
chr3_+_103914560 0.546 ENSMUST00000106806.1
Rsbn1
rosbin, round spermatid basic protein 1
chr2_+_109890846 0.532 ENSMUST00000028583.7
Lin7c
lin-7 homolog C (C. elegans)
chrX_-_103981242 0.524 ENSMUST00000121153.1
ENSMUST00000070705.4
Rlim

ring finger protein, LIM domain interacting

chr11_-_51756378 0.514 ENSMUST00000109092.1
ENSMUST00000064297.4
ENSMUST00000109097.2
Sec24a


Sec24 related gene family, member A (S. cerevisiae)


chr4_-_149774238 0.510 ENSMUST00000105686.2
Slc25a33
solute carrier family 25, member 33
chr2_-_38287174 0.451 ENSMUST00000130472.1
Dennd1a
DENN/MADD domain containing 1A
chrX_+_7722267 0.449 ENSMUST00000125991.1
ENSMUST00000148624.1
Wdr45

WD repeat domain 45

chr11_+_117654798 0.425 ENSMUST00000106344.1
Tnrc6c
trinucleotide repeat containing 6C
chr9_+_25252439 0.411 ENSMUST00000115272.2
ENSMUST00000165594.2
Sept7

septin 7

chr7_-_116443439 0.384 ENSMUST00000170430.1
Pik3c2a
phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide
chr19_-_53944621 0.383 ENSMUST00000135402.2
Bbip1
BBSome interacting protein 1
chr2_+_149830840 0.340 ENSMUST00000109934.1
ENSMUST00000140870.1
Syndig1

synapse differentiation inducing 1

chrX_+_7723278 0.300 ENSMUST00000144148.1
Wdr45
WD repeat domain 45
chr2_+_22895583 0.292 ENSMUST00000152170.1
Pdss1
prenyl (solanesyl) diphosphate synthase, subunit 1
chr17_-_79020816 0.264 ENSMUST00000168887.1
ENSMUST00000119284.1
Prkd3

protein kinase D3

chr2_-_150904620 0.246 ENSMUST00000056149.8
Abhd12
abhydrolase domain containing 12
chr3_-_88455302 0.242 ENSMUST00000125526.1
Sema4a
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr2_+_149830788 0.229 ENSMUST00000109935.1
Syndig1
synapse differentiation inducing 1
chr14_+_56887795 0.227 ENSMUST00000022511.8
Zmym2
zinc finger, MYM-type 2
chr9_-_44735189 0.217 ENSMUST00000034611.8
Phldb1
pleckstrin homology-like domain, family B, member 1
chr2_+_102658640 0.200 ENSMUST00000080210.3
Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr3_-_94786469 0.200 ENSMUST00000107273.1
Cgn
cingulin
chr2_-_6935081 0.186 ENSMUST00000100426.2
Gm10855
predicted gene 10855
chr1_+_136131382 0.182 ENSMUST00000075164.4
Kif21b
kinesin family member 21B
chr10_-_127211528 0.164 ENSMUST00000013970.7
Pip4k2c
phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
chr15_-_97831460 0.155 ENSMUST00000079838.7
ENSMUST00000118294.1
Hdac7

histone deacetylase 7

chrX_+_73716577 0.144 ENSMUST00000002084.7
Abcd1
ATP-binding cassette, sub-family D (ALD), member 1
chrX_+_93675088 0.135 ENSMUST00000045898.3
Pcyt1b
phosphate cytidylyltransferase 1, choline, beta isoform
chr3_-_94786430 0.130 ENSMUST00000107272.1
Cgn
cingulin
chr2_-_34754364 0.110 ENSMUST00000142436.1
ENSMUST00000113099.3
ENSMUST00000028224.8
Gapvd1


GTPase activating protein and VPS9 domains 1


chr19_-_42752710 0.098 ENSMUST00000076505.3
Pyroxd2
pyridine nucleotide-disulphide oxidoreductase domain 2
chr17_-_63863791 0.091 ENSMUST00000050753.3
A930002H24Rik
RIKEN cDNA A930002H24 gene
chr7_+_19004047 0.085 ENSMUST00000053713.3
Irf2bp1
interferon regulatory factor 2 binding protein 1
chr13_+_30659999 0.065 ENSMUST00000091672.6
ENSMUST00000110310.1
ENSMUST00000095914.5
Dusp22


dual specificity phosphatase 22


chr5_+_28165690 0.056 ENSMUST00000036177.7
En2
engrailed 2
chr9_-_110117303 0.047 ENSMUST00000136969.1
Dhx30
DEAH (Asp-Glu-Ala-His) box polypeptide 30
chr1_-_54194048 0.038 ENSMUST00000120904.1
Hecw2
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
chr19_+_42518795 0.037 ENSMUST00000160107.1
ENSMUST00000160893.1
R3hcc1l

R3H domain and coiled-coil containing 1 like

chr12_+_3572379 0.035 ENSMUST00000173199.1
ENSMUST00000164578.2
ENSMUST00000174479.1
ENSMUST00000173240.1
ENSMUST00000174663.1
ENSMUST00000173736.1
Dtnb





dystrobrevin, beta





chr9_-_110117379 0.029 ENSMUST00000111991.2
ENSMUST00000149199.1
ENSMUST00000035056.7
ENSMUST00000148287.1
ENSMUST00000127744.1
Dhx30




DEAH (Asp-Glu-Ala-His) box polypeptide 30




chr11_-_102218923 0.023 ENSMUST00000131254.1
Hdac5
histone deacetylase 5
chr10_+_121365078 0.017 ENSMUST00000040344.6
Gns
glucosamine (N-acetyl)-6-sulfatase
chr2_-_153015331 0.006 ENSMUST00000028972.8
Pdrg1
p53 and DNA damage regulated 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 5.4 GO:0010624 regulation of Schwann cell proliferation(GO:0010624)
0.7 2.8 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.6 3.5 GO:0042045 epithelial fluid transport(GO:0042045)
0.5 0.9 GO:0086047 membrane depolarization during Purkinje myocyte cell action potential(GO:0086047)
0.3 1.4 GO:0072531 pyrimidine-containing compound transmembrane transport(GO:0072531)
0.3 1.0 GO:0014877 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.3 1.0 GO:0097212 lysosomal membrane organization(GO:0097212)
0.3 1.2 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.3 2.7 GO:0010459 negative regulation of heart rate(GO:0010459)
0.2 1.9 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.2 1.9 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.2 1.3 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.1 0.7 GO:0051012 microtubule sliding(GO:0051012)
0.1 0.9 GO:0032811 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) negative regulation of epinephrine secretion(GO:0032811)
0.1 0.9 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.1 0.4 GO:0071579 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092) regulation of zinc ion transport(GO:0071579)
0.1 0.4 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.1 0.5 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.1 0.5 GO:1900095 regulation of dosage compensation by inactivation of X chromosome(GO:1900095)
0.1 0.5 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.1 2.0 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.1 0.2 GO:0046462 monoacylglycerol metabolic process(GO:0046462)
0.1 0.5 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.1 0.7 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.0 1.1 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.0 0.6 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.0 1.0 GO:0008340 determination of adult lifespan(GO:0008340)
0.0 0.1 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.0 0.3 GO:0089700 protein kinase D signaling(GO:0089700)
0.0 0.2 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.4 GO:0045974 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.0 0.4 GO:0031268 pseudopodium organization(GO:0031268)
0.0 0.6 GO:0097091 synaptic vesicle clustering(GO:0097091)
0.0 0.2 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.0 0.2 GO:2001197 regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.0 0.8 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.7 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 0.3 GO:0006744 ubiquinone biosynthetic process(GO:0006744)
0.0 0.2 GO:2000786 positive regulation of autophagosome assembly(GO:2000786)
0.0 0.1 GO:1902775 mitochondrial large ribosomal subunit assembly(GO:1902775)
0.0 0.2 GO:0045063 T-helper 1 cell differentiation(GO:0045063)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 5.4 GO:0097450 astrocyte end-foot(GO:0097450)
1.2 3.5 GO:0031088 platelet dense granule membrane(GO:0031088)
0.9 2.8 GO:0072534 perineuronal net(GO:0072534)
0.2 0.9 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.1 0.4 GO:0005940 septin ring(GO:0005940)
0.1 0.6 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.1 2.0 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 0.5 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.1 1.2 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 0.9 GO:0034706 sodium channel complex(GO:0034706)
0.1 0.7 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.1 1.3 GO:0000242 pericentriolar material(GO:0000242)
0.0 0.4 GO:0034464 BBSome(GO:0034464)
0.0 1.9 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 0.5 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.9 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.2 GO:0045180 basal cortex(GO:0045180)
0.0 1.0 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.3 GO:0016605 PML body(GO:0016605)
0.0 0.5 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.0 0.9 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.6 GO:0031901 early endosome membrane(GO:0031901)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.5 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.4 1.6 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.3 1.9 GO:0005042 netrin receptor activity(GO:0005042)
0.2 0.9 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.2 2.8 GO:0046625 sphingolipid binding(GO:0046625)
0.2 0.9 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.1 0.5 GO:0097016 L27 domain binding(GO:0097016)
0.1 1.9 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 0.9 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.1 0.3 GO:0050347 trans-hexaprenyltranstransferase activity(GO:0000010) trans-octaprenyltranstransferase activity(GO:0050347)
0.1 5.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 1.1 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 1.4 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)
0.1 0.2 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.4 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.2 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.9 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.0 0.7 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.1 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.0 0.1 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 0.2 GO:0004622 lysophospholipase activity(GO:0004622) acylglycerol lipase activity(GO:0047372)
0.0 0.5 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 1.2 GO:0035591 signaling adaptor activity(GO:0035591)
0.0 0.3 GO:0004697 protein kinase C activity(GO:0004697)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.5 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 1.9 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.1 1.6 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 1.9 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.9 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 2.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.2 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 1.0 PID_FOXO_PATHWAY FoxO family signaling
0.0 0.6 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 0.8 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.6 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.1 1.9 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.1 5.4 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.1 1.9 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING Genes involved in Spry regulation of FGF signaling
0.1 0.9 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 2.4 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.9 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.4 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 1.3 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.4 REACTOME_REGULATORY_RNA_PATHWAYS Genes involved in Regulatory RNA pathways
0.0 0.3 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 1.1 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors