Motif ID: Mef2d_Mef2a
Z-value: 1.206


Transcription factors associated with Mef2d_Mef2a:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Mef2a | ENSMUSG00000030557.10 | Mef2a |
Mef2d | ENSMUSG00000001419.11 | Mef2d |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Mef2a | mm10_v2_chr7_-_67372846_67372858 | 0.88 | 1.5e-06 | Click! |
Mef2d | mm10_v2_chr3_+_88142328_88142483 | 0.55 | 1.8e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.6 | 7.8 | GO:0007521 | muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111) |
1.5 | 4.6 | GO:0001928 | regulation of exocyst assembly(GO:0001928) |
1.5 | 4.5 | GO:0032241 | positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256) |
1.3 | 3.9 | GO:0035790 | platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790) |
1.1 | 5.4 | GO:0032485 | regulation of Ral protein signal transduction(GO:0032485) |
1.0 | 6.3 | GO:0015015 | heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015) |
1.0 | 4.1 | GO:0099566 | regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566) |
1.0 | 10.9 | GO:0042572 | retinol metabolic process(GO:0042572) |
0.9 | 2.6 | GO:0070375 | ERK5 cascade(GO:0070375) |
0.8 | 4.1 | GO:0042636 | negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279) |
0.7 | 2.1 | GO:0007525 | somatic muscle development(GO:0007525) |
0.7 | 2.7 | GO:0007066 | female meiosis sister chromatid cohesion(GO:0007066) |
0.6 | 1.9 | GO:0002182 | cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248) |
0.6 | 3.5 | GO:1902261 | positive regulation of delayed rectifier potassium channel activity(GO:1902261) |
0.6 | 7.8 | GO:0045161 | neuronal ion channel clustering(GO:0045161) |
0.5 | 2.6 | GO:0035063 | nuclear speck organization(GO:0035063) |
0.5 | 3.8 | GO:2000766 | negative regulation of cytoplasmic translation(GO:2000766) |
0.5 | 2.4 | GO:0046684 | response to pyrethroid(GO:0046684) |
0.4 | 2.2 | GO:0002121 | inter-male aggressive behavior(GO:0002121) |
0.4 | 1.7 | GO:1904048 | negative regulation of synaptic vesicle recycling(GO:1903422) regulation of spontaneous neurotransmitter secretion(GO:1904048) |
0.4 | 1.7 | GO:1904425 | negative regulation of GTP binding(GO:1904425) |
0.4 | 1.3 | GO:1903538 | meiotic cell cycle process involved in oocyte maturation(GO:1903537) regulation of meiotic cell cycle process involved in oocyte maturation(GO:1903538) |
0.4 | 3.3 | GO:0002862 | negative regulation of inflammatory response to antigenic stimulus(GO:0002862) |
0.4 | 1.2 | GO:1903279 | regulation of calcium:sodium antiporter activity(GO:1903279) |
0.4 | 2.4 | GO:0034773 | histone H4-K20 trimethylation(GO:0034773) establishment of Sertoli cell barrier(GO:0097368) |
0.4 | 2.3 | GO:0046103 | ADP biosynthetic process(GO:0006172) inosine biosynthetic process(GO:0046103) |
0.3 | 1.6 | GO:2000255 | negative regulation of male germ cell proliferation(GO:2000255) |
0.3 | 2.4 | GO:0097118 | neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118) |
0.3 | 2.3 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
0.3 | 3.0 | GO:0010650 | positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
0.3 | 1.8 | GO:0014819 | regulation of skeletal muscle contraction(GO:0014819) |
0.3 | 1.6 | GO:0099525 | presynaptic dense core granule exocytosis(GO:0099525) |
0.3 | 1.0 | GO:0051643 | endoplasmic reticulum localization(GO:0051643) |
0.2 | 0.5 | GO:1901420 | negative regulation of response to alcohol(GO:1901420) |
0.2 | 1.7 | GO:0043553 | negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) |
0.2 | 1.4 | GO:0098964 | dendritic transport of ribonucleoprotein complex(GO:0098961) dendritic transport of messenger ribonucleoprotein complex(GO:0098963) anterograde dendritic transport of messenger ribonucleoprotein complex(GO:0098964) |
0.2 | 3.3 | GO:0061469 | regulation of type B pancreatic cell proliferation(GO:0061469) |
0.2 | 1.2 | GO:0003105 | negative regulation of glomerular filtration(GO:0003105) |
0.2 | 2.0 | GO:0034983 | peptidyl-lysine deacetylation(GO:0034983) |
0.2 | 0.7 | GO:0060399 | positive regulation of growth hormone receptor signaling pathway(GO:0060399) |
0.2 | 1.2 | GO:0010747 | positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747) |
0.2 | 1.9 | GO:0070842 | aggresome assembly(GO:0070842) |
0.2 | 1.1 | GO:0051694 | pointed-end actin filament capping(GO:0051694) |
0.2 | 2.2 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
0.2 | 0.4 | GO:1903275 | positive regulation of sodium ion export(GO:1903275) positive regulation of sodium ion export from cell(GO:1903278) |
0.2 | 2.1 | GO:0031272 | regulation of pseudopodium assembly(GO:0031272) |
0.2 | 1.1 | GO:0098909 | establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200) regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909) |
0.1 | 0.9 | GO:1902998 | macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
0.1 | 1.3 | GO:1902866 | regulation of retina development in camera-type eye(GO:1902866) |
0.1 | 1.1 | GO:0060120 | auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120) |
0.1 | 1.7 | GO:0006883 | cellular sodium ion homeostasis(GO:0006883) |
0.1 | 0.5 | GO:0014874 | response to stimulus involved in regulation of muscle adaptation(GO:0014874) |
0.1 | 0.4 | GO:1904457 | positive regulation of neuronal action potential(GO:1904457) |
0.1 | 1.7 | GO:2001014 | regulation of skeletal muscle cell differentiation(GO:2001014) |
0.1 | 0.6 | GO:0034587 | piRNA metabolic process(GO:0034587) |
0.1 | 1.1 | GO:0001553 | luteinization(GO:0001553) |
0.1 | 4.5 | GO:0034605 | cellular response to heat(GO:0034605) |
0.1 | 0.3 | GO:0010752 | signal complex assembly(GO:0007172) regulation of cGMP-mediated signaling(GO:0010752) |
0.1 | 0.8 | GO:0006013 | mannose metabolic process(GO:0006013) |
0.1 | 3.5 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
0.1 | 2.1 | GO:0032011 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
0.1 | 0.2 | GO:1902256 | endocardial cushion fusion(GO:0003274) apoptotic process involved in outflow tract morphogenesis(GO:0003275) septum primum development(GO:0003284) atrial septum primum morphogenesis(GO:0003289) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910) regulation of catagen(GO:0051794) positive regulation of catagen(GO:0051795) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256) |
0.1 | 0.7 | GO:1903025 | regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025) |
0.1 | 0.4 | GO:0002024 | diet induced thermogenesis(GO:0002024) |
0.1 | 0.3 | GO:0032497 | detection of lipopolysaccharide(GO:0032497) |
0.1 | 6.2 | GO:0001578 | microtubule bundle formation(GO:0001578) |
0.1 | 0.6 | GO:0046543 | development of secondary female sexual characteristics(GO:0046543) |
0.1 | 0.3 | GO:0070459 | prolactin secretion(GO:0070459) |
0.1 | 0.4 | GO:0003011 | involuntary skeletal muscle contraction(GO:0003011) |
0.1 | 1.2 | GO:0010866 | regulation of triglyceride biosynthetic process(GO:0010866) |
0.1 | 0.8 | GO:0010758 | regulation of macrophage chemotaxis(GO:0010758) |
0.1 | 0.2 | GO:0006553 | lysine metabolic process(GO:0006553) |
0.1 | 0.5 | GO:0014883 | transition between fast and slow fiber(GO:0014883) |
0.0 | 0.2 | GO:0045085 | negative regulation of interleukin-2 biosynthetic process(GO:0045085) |
0.0 | 0.0 | GO:0003219 | cardiac right ventricle formation(GO:0003219) |
0.0 | 2.2 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
0.0 | 0.8 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
0.0 | 4.4 | GO:0006342 | chromatin silencing(GO:0006342) |
0.0 | 4.0 | GO:0006892 | post-Golgi vesicle-mediated transport(GO:0006892) |
0.0 | 2.4 | GO:0043044 | ATP-dependent chromatin remodeling(GO:0043044) |
0.0 | 0.1 | GO:0046900 | tetrahydrofolylpolyglutamate metabolic process(GO:0046900) |
0.0 | 1.1 | GO:0045604 | regulation of epidermal cell differentiation(GO:0045604) |
0.0 | 0.1 | GO:2000642 | negative regulation of early endosome to late endosome transport(GO:2000642) |
0.0 | 0.9 | GO:0070536 | protein K63-linked deubiquitination(GO:0070536) |
0.0 | 0.7 | GO:0008090 | retrograde axonal transport(GO:0008090) |
0.0 | 2.5 | GO:0007613 | memory(GO:0007613) |
0.0 | 0.2 | GO:2000074 | regulation of type B pancreatic cell development(GO:2000074) |
0.0 | 0.2 | GO:0015840 | urea transport(GO:0015840) |
0.0 | 1.2 | GO:0016601 | Rac protein signal transduction(GO:0016601) |
0.0 | 0.1 | GO:0002188 | translation reinitiation(GO:0002188) |
0.0 | 5.3 | GO:0031032 | actomyosin structure organization(GO:0031032) |
0.0 | 1.1 | GO:0021799 | cerebral cortex radially oriented cell migration(GO:0021799) |
0.0 | 1.0 | GO:0010614 | negative regulation of cardiac muscle hypertrophy(GO:0010614) |
0.0 | 0.5 | GO:0006047 | UDP-N-acetylglucosamine metabolic process(GO:0006047) |
0.0 | 4.1 | GO:0048813 | dendrite morphogenesis(GO:0048813) |
0.0 | 1.6 | GO:0021766 | hippocampus development(GO:0021766) |
0.0 | 4.0 | GO:0050806 | positive regulation of synaptic transmission(GO:0050806) |
0.0 | 0.5 | GO:0007143 | female meiotic division(GO:0007143) |
0.0 | 1.0 | GO:0030514 | negative regulation of BMP signaling pathway(GO:0030514) |
0.0 | 0.2 | GO:0035428 | hexose transmembrane transport(GO:0035428) |
0.0 | 0.5 | GO:0070296 | sarcoplasmic reticulum calcium ion transport(GO:0070296) |
0.0 | 0.3 | GO:0006817 | phosphate ion transport(GO:0006817) |
0.0 | 0.0 | GO:0071286 | cellular response to magnesium ion(GO:0071286) |
0.0 | 1.8 | GO:0030833 | regulation of actin filament polymerization(GO:0030833) |
0.0 | 1.0 | GO:0070373 | negative regulation of ERK1 and ERK2 cascade(GO:0070373) |
0.0 | 0.2 | GO:0046475 | glycerophospholipid catabolic process(GO:0046475) |
0.0 | 1.2 | GO:0010811 | positive regulation of cell-substrate adhesion(GO:0010811) |
0.0 | 0.5 | GO:0015909 | long-chain fatty acid transport(GO:0015909) |
0.0 | 2.6 | GO:0060541 | respiratory system development(GO:0060541) |
0.0 | 0.2 | GO:0019363 | pyridine nucleotide biosynthetic process(GO:0019363) |
0.0 | 1.1 | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332) |
0.0 | 1.1 | GO:0007098 | centrosome cycle(GO:0007098) |
0.0 | 0.6 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.4 | 4.1 | GO:0043512 | inhibin A complex(GO:0043512) |
0.9 | 2.7 | GO:0000802 | transverse filament(GO:0000802) |
0.8 | 3.2 | GO:0090537 | CERF complex(GO:0090537) |
0.4 | 7.8 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
0.3 | 7.2 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
0.3 | 1.0 | GO:0042642 | actomyosin, myosin complex part(GO:0042642) |
0.3 | 5.3 | GO:0032279 | asymmetric synapse(GO:0032279) |
0.3 | 1.6 | GO:0098831 | presynaptic active zone cytoplasmic component(GO:0098831) |
0.3 | 2.3 | GO:0001520 | outer dense fiber(GO:0001520) |
0.3 | 4.1 | GO:0043083 | synaptic cleft(GO:0043083) |
0.3 | 0.8 | GO:0005927 | muscle tendon junction(GO:0005927) |
0.3 | 2.4 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
0.2 | 1.0 | GO:0008282 | ATP-sensitive potassium channel complex(GO:0008282) |
0.2 | 3.5 | GO:0005614 | interstitial matrix(GO:0005614) |
0.2 | 0.7 | GO:0031673 | H zone(GO:0031673) |
0.2 | 1.2 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
0.2 | 1.7 | GO:0048787 | presynaptic active zone membrane(GO:0048787) |
0.2 | 2.4 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
0.1 | 3.0 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
0.1 | 0.9 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
0.1 | 0.5 | GO:0071148 | TEAD-1-YAP complex(GO:0071148) |
0.1 | 0.4 | GO:0044316 | cone cell pedicle(GO:0044316) |
0.1 | 2.0 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
0.1 | 2.1 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
0.1 | 1.2 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
0.1 | 0.7 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
0.1 | 3.0 | GO:0034707 | chloride channel complex(GO:0034707) |
0.1 | 0.3 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
0.1 | 4.2 | GO:0016328 | lateral plasma membrane(GO:0016328) |
0.1 | 0.3 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
0.1 | 2.2 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
0.0 | 5.0 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
0.0 | 1.1 | GO:0005865 | striated muscle thin filament(GO:0005865) myofilament(GO:0036379) |
0.0 | 1.1 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
0.0 | 2.1 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
0.0 | 0.4 | GO:0032982 | myosin filament(GO:0032982) |
0.0 | 0.7 | GO:0010369 | chromocenter(GO:0010369) |
0.0 | 0.8 | GO:0048786 | presynaptic active zone(GO:0048786) |
0.0 | 7.8 | GO:0009897 | external side of plasma membrane(GO:0009897) |
0.0 | 0.4 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
0.0 | 5.2 | GO:0001650 | fibrillar center(GO:0001650) |
0.0 | 1.6 | GO:0045171 | intercellular bridge(GO:0045171) |
0.0 | 3.3 | GO:0031965 | nuclear membrane(GO:0031965) |
0.0 | 0.2 | GO:0005664 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
0.0 | 1.3 | GO:0031594 | neuromuscular junction(GO:0031594) |
0.0 | 0.3 | GO:0005922 | connexon complex(GO:0005922) |
0.0 | 6.2 | GO:0045211 | postsynaptic membrane(GO:0045211) |
0.0 | 2.2 | GO:0043198 | dendritic shaft(GO:0043198) |
0.0 | 8.5 | GO:0016607 | nuclear speck(GO:0016607) |
0.0 | 1.8 | GO:0000118 | histone deacetylase complex(GO:0000118) |
0.0 | 0.6 | GO:0043204 | perikaryon(GO:0043204) |
0.0 | 0.6 | GO:0044291 | cell-cell contact zone(GO:0044291) |
0.0 | 1.7 | GO:0016605 | PML body(GO:0016605) |
0.0 | 0.5 | GO:0032420 | stereocilium(GO:0032420) |
0.0 | 0.5 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
0.0 | 0.1 | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541) |
0.0 | 3.0 | GO:0030054 | cell junction(GO:0030054) |
0.0 | 0.6 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.6 | 11.3 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
1.6 | 6.3 | GO:0017095 | heparan sulfate 6-O-sulfotransferase activity(GO:0017095) |
1.1 | 6.6 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
1.1 | 6.5 | GO:0070699 | type II activin receptor binding(GO:0070699) |
1.1 | 3.2 | GO:0070615 | nucleosome-dependent ATPase activity(GO:0070615) |
0.8 | 3.9 | GO:0038085 | vascular endothelial growth factor binding(GO:0038085) |
0.6 | 4.5 | GO:0001609 | G-protein coupled adenosine receptor activity(GO:0001609) heterotrimeric G-protein binding(GO:0032795) |
0.6 | 1.8 | GO:0008113 | peptide-methionine (S)-S-oxide reductase activity(GO:0008113) |
0.6 | 1.7 | GO:0036313 | phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313) |
0.5 | 4.1 | GO:0099583 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583) |
0.4 | 1.6 | GO:0004667 | prostaglandin-D synthase activity(GO:0004667) |
0.4 | 7.8 | GO:0035198 | miRNA binding(GO:0035198) |
0.3 | 7.8 | GO:0004385 | guanylate kinase activity(GO:0004385) |
0.3 | 5.7 | GO:0000900 | translation repressor activity, nucleic acid binding(GO:0000900) |
0.3 | 2.1 | GO:0086008 | voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008) |
0.2 | 4.5 | GO:0030275 | LRR domain binding(GO:0030275) |
0.2 | 2.3 | GO:0004017 | adenylate kinase activity(GO:0004017) |
0.2 | 5.7 | GO:0042805 | actinin binding(GO:0042805) |
0.2 | 3.5 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
0.2 | 1.7 | GO:0005225 | volume-sensitive anion channel activity(GO:0005225) |
0.1 | 2.3 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
0.1 | 1.6 | GO:0019992 | diacylglycerol binding(GO:0019992) |
0.1 | 4.2 | GO:0051018 | protein kinase A binding(GO:0051018) |
0.1 | 1.2 | GO:1990239 | steroid hormone binding(GO:1990239) |
0.1 | 3.5 | GO:0001968 | fibronectin binding(GO:0001968) |
0.1 | 1.0 | GO:0070410 | co-SMAD binding(GO:0070410) |
0.1 | 1.1 | GO:0005523 | tropomyosin binding(GO:0005523) |
0.1 | 0.3 | GO:0001875 | lipopolysaccharide receptor activity(GO:0001875) |
0.1 | 2.5 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
0.1 | 2.7 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
0.1 | 2.4 | GO:0005248 | voltage-gated sodium channel activity(GO:0005248) |
0.1 | 0.5 | GO:0004095 | carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416) |
0.1 | 0.5 | GO:0008761 | UDP-N-acetylglucosamine 2-epimerase activity(GO:0008761) |
0.1 | 0.3 | GO:0005436 | sodium:phosphate symporter activity(GO:0005436) sodium:inorganic phosphate symporter activity(GO:0015319) |
0.1 | 1.8 | GO:0017049 | GTP-Rho binding(GO:0017049) |
0.1 | 1.8 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
0.1 | 2.1 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
0.1 | 0.8 | GO:0015924 | mannosyl-oligosaccharide mannosidase activity(GO:0015924) |
0.1 | 1.2 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
0.1 | 0.2 | GO:0034714 | type III transforming growth factor beta receptor binding(GO:0034714) |
0.1 | 1.0 | GO:0043008 | ATP-dependent protein binding(GO:0043008) |
0.1 | 0.8 | GO:0030955 | potassium ion binding(GO:0030955) |
0.1 | 3.0 | GO:0030507 | spectrin binding(GO:0030507) |
0.0 | 0.2 | GO:0015254 | glycerol channel activity(GO:0015254) |
0.0 | 0.9 | GO:0051787 | misfolded protein binding(GO:0051787) |
0.0 | 0.3 | GO:0004972 | NMDA glutamate receptor activity(GO:0004972) |
0.0 | 4.0 | GO:0008083 | growth factor activity(GO:0008083) |
0.0 | 0.2 | GO:0050786 | RAGE receptor binding(GO:0050786) |
0.0 | 0.2 | GO:0016647 | oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647) |
0.0 | 1.3 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
0.0 | 2.5 | GO:0048365 | Rac GTPase binding(GO:0048365) |
0.0 | 1.7 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
0.0 | 0.5 | GO:0001134 | transcription factor activity, transcription factor recruiting(GO:0001134) |
0.0 | 7.2 | GO:0008017 | microtubule binding(GO:0008017) |
0.0 | 1.4 | GO:0019894 | kinesin binding(GO:0019894) |
0.0 | 1.4 | GO:0042562 | hormone binding(GO:0042562) |
0.0 | 2.1 | GO:0030674 | protein binding, bridging(GO:0030674) |
0.0 | 0.7 | GO:0017147 | Wnt-protein binding(GO:0017147) |
0.0 | 0.7 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
0.0 | 0.1 | GO:0030375 | thyroid hormone receptor coactivator activity(GO:0030375) |
0.0 | 1.4 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
0.0 | 2.7 | GO:0004930 | G-protein coupled receptor activity(GO:0004930) |
0.0 | 0.5 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
0.0 | 0.4 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
0.0 | 0.3 | GO:0008483 | transaminase activity(GO:0008483) |
0.0 | 2.6 | GO:0005516 | calmodulin binding(GO:0005516) |
0.0 | 0.4 | GO:0030552 | cAMP binding(GO:0030552) |
0.0 | 0.2 | GO:0003688 | DNA replication origin binding(GO:0003688) |
0.0 | 0.2 | GO:0004622 | lysophospholipase activity(GO:0004622) |
0.0 | 0.5 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
0.0 | 0.1 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
0.0 | 0.8 | GO:0001191 | transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191) |
0.0 | 0.6 | GO:0008408 | 3'-5' exonuclease activity(GO:0008408) |
0.0 | 0.3 | GO:0008327 | methyl-CpG binding(GO:0008327) |
0.0 | 2.5 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 3.8 | PID_FGF_PATHWAY | FGF signaling pathway |
0.2 | 10.8 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
0.2 | 7.0 | PID_MAPK_TRK_PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
0.1 | 4.1 | PID_ALK1_PATHWAY | ALK1 signaling events |
0.1 | 1.5 | PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY | Signaling mediated by p38-alpha and p38-beta |
0.1 | 3.3 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
0.1 | 4.1 | PID_REELIN_PATHWAY | Reelin signaling pathway |
0.1 | 2.8 | ST_ERK1_ERK2_MAPK_PATHWAY | ERK1/ERK2 MAPK Pathway |
0.1 | 2.5 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
0.0 | 1.3 | PID_ANGIOPOIETIN_RECEPTOR_PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
0.0 | 1.2 | PID_IL8_CXCR2_PATHWAY | IL8- and CXCR2-mediated signaling events |
0.0 | 1.7 | PID_KIT_PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
0.0 | 0.2 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
0.0 | 2.9 | PID_HDAC_CLASSI_PATHWAY | Signaling events mediated by HDAC Class I |
0.0 | 4.3 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
0.0 | 0.8 | PID_ARF6_PATHWAY | Arf6 signaling events |
0.0 | 0.7 | PID_EPHRINB_REV_PATHWAY | Ephrin B reverse signaling |
0.0 | 1.1 | PID_P73PATHWAY | p73 transcription factor network |
0.0 | 0.3 | SA_PTEN_PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
0.0 | 0.1 | ST_G_ALPHA_I_PATHWAY | G alpha i Pathway |
0.0 | 0.3 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
0.0 | 0.5 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.1 | 3.3 | REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS | Genes involved in Eicosanoid ligand-binding receptors |
1.0 | 4.1 | REACTOME_GLYCOPROTEIN_HORMONES | Genes involved in Glycoprotein hormones |
0.4 | 4.5 | REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS | Genes involved in Nucleotide-like (purinergic) receptors |
0.3 | 9.3 | REACTOME_ERK_MAPK_TARGETS | Genes involved in ERK/MAPK targets |
0.2 | 4.6 | REACTOME_NEPHRIN_INTERACTIONS | Genes involved in Nephrin interactions |
0.2 | 2.5 | REACTOME_ACTIVATION_OF_RAC | Genes involved in Activation of Rac |
0.2 | 6.3 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
0.1 | 3.3 | REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
0.1 | 1.7 | REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
0.1 | 4.6 | REACTOME_INTERFERON_GAMMA_SIGNALING | Genes involved in Interferon gamma signaling |
0.1 | 0.2 | REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
0.1 | 3.0 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
0.1 | 3.4 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
0.1 | 2.3 | REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
0.1 | 1.3 | REACTOME_TIE2_SIGNALING | Genes involved in Tie2 Signaling |
0.1 | 1.1 | REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
0.1 | 3.1 | REACTOME_PIP3_ACTIVATES_AKT_SIGNALING | Genes involved in PIP3 activates AKT signaling |
0.1 | 3.9 | REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION | Genes involved in Downstream signal transduction |
0.0 | 1.0 | REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING | Genes involved in Insulin Synthesis and Processing |
0.0 | 1.2 | REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
0.0 | 1.2 | REACTOME_THE_ROLE_OF_NEF_IN_HIV1_REPLICATION_AND_DISEASE_PATHOGENESIS | Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis |
0.0 | 0.3 | REACTOME_TRAF6_MEDIATED_INDUCTION_OF_TAK1_COMPLEX | Genes involved in TRAF6 mediated induction of TAK1 complex |
0.0 | 1.1 | REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ | Genes involved in Response to elevated platelet cytosolic Ca2+ |
0.0 | 1.0 | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
0.0 | 1.8 | REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
0.0 | 1.1 | REACTOME_INWARDLY_RECTIFYING_K_CHANNELS | Genes involved in Inwardly rectifying K+ channels |
0.0 | 0.5 | REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
0.0 | 0.2 | REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
0.0 | 0.4 | REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_GLUCAGON_LIKE_PEPTIDE1 | Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1 |
0.0 | 0.6 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
0.0 | 0.3 | REACTOME_GAP_JUNCTION_ASSEMBLY | Genes involved in Gap junction assembly |
0.0 | 0.8 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
0.0 | 0.7 | REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
0.0 | 0.3 | REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |