Motif ID: Gsc2_Dmbx1

Z-value: 0.501

Transcription factors associated with Gsc2_Dmbx1:

Gene SymbolEntrez IDGene Name
Dmbx1 ENSMUSG00000028707.9 Dmbx1
Gsc2 ENSMUSG00000022738.6 Gsc2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dmbx1mm10_v2_chr4_-_115939923_1159399280.174.9e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Gsc2_Dmbx1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_137766474 2.110 ENSMUST00000139951.1
Alpl
alkaline phosphatase, liver/bone/kidney
chr14_-_118052235 1.525 ENSMUST00000022725.2
Dct
dopachrome tautomerase
chr2_+_164562579 1.343 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
Wfdc2


WAP four-disulfide core domain 2


chr17_+_35861318 1.296 ENSMUST00000074259.8
ENSMUST00000174873.1
Nrm

nurim (nuclear envelope membrane protein)

chr17_+_35861343 1.013 ENSMUST00000172931.1
Nrm
nurim (nuclear envelope membrane protein)
chr11_-_68973840 0.999 ENSMUST00000038644.4
Rangrf
RAN guanine nucleotide release factor
chrM_+_8600 0.977 ENSMUST00000082409.1
mt-Co3
mitochondrially encoded cytochrome c oxidase III
chr4_-_141053660 0.974 ENSMUST00000040222.7
Crocc
ciliary rootlet coiled-coil, rootletin
chr7_-_133015248 0.908 ENSMUST00000169570.1
Ctbp2
C-terminal binding protein 2
chr5_+_77265454 0.865 ENSMUST00000080359.5
Rest
RE1-silencing transcription factor
chr13_-_116309639 0.791 ENSMUST00000036060.6
Isl1
ISL1 transcription factor, LIM/homeodomain
chr9_+_50617516 0.780 ENSMUST00000141366.1
Pih1d2
PIH1 domain containing 2
chr11_+_113659283 0.722 ENSMUST00000137878.1
Cog1
component of oligomeric golgi complex 1
chr4_+_154960915 0.649 ENSMUST00000049621.6
Hes5
hairy and enhancer of split 5 (Drosophila)
chr17_-_58991343 0.627 ENSMUST00000025064.7
2610034M16Rik
RIKEN cDNA 2610034M16 gene
chr7_-_15879844 0.615 ENSMUST00000172758.1
ENSMUST00000044434.6
Crx

cone-rod homeobox containing gene

chr13_-_23562369 0.605 ENSMUST00000105107.1
Hist1h3e
histone cluster 1, H3e
chr1_+_12692430 0.571 ENSMUST00000180062.1
ENSMUST00000177608.1
Sulf1

sulfatase 1

chr11_-_52282564 0.548 ENSMUST00000086844.3
Tcf7
transcription factor 7, T cell specific
chr7_-_105752193 0.523 ENSMUST00000033184.4
Tpp1
tripeptidyl peptidase I
chr19_-_12765447 0.518 ENSMUST00000112933.1
Cntf
ciliary neurotrophic factor
chr13_-_21783391 0.516 ENSMUST00000099704.3
Hist1h3i
histone cluster 1, H3i
chr14_-_31640878 0.501 ENSMUST00000167066.1
ENSMUST00000127204.2
ENSMUST00000022437.8
Hacl1


2-hydroxyacyl-CoA lyase 1


chr2_-_121456693 0.497 ENSMUST00000110613.2
ENSMUST00000056312.3
Serinc4

serine incorporator 4

chrX_+_134585644 0.483 ENSMUST00000113211.1
Rpl36a
ribosomal protein L36A
chr6_-_124840192 0.453 ENSMUST00000024206.5
Gnb3
guanine nucleotide binding protein (G protein), beta 3
chr2_+_120476911 0.447 ENSMUST00000110716.1
ENSMUST00000028748.6
ENSMUST00000090028.5
ENSMUST00000110719.2
Capn3



calpain 3



chr16_-_35490873 0.446 ENSMUST00000023550.7
Pdia5
protein disulfide isomerase associated 5
chr3_-_8964037 0.432 ENSMUST00000091354.5
ENSMUST00000094381.4
Tpd52

tumor protein D52

chr16_-_46010212 0.428 ENSMUST00000130481.1
Plcxd2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr11_-_90687572 0.402 ENSMUST00000107869.2
ENSMUST00000154599.1
ENSMUST00000107868.1
ENSMUST00000020849.2
Tom1l1



target of myb1-like 1 (chicken)



chr10_-_22149270 0.402 ENSMUST00000179054.1
ENSMUST00000069372.6
E030030I06Rik

RIKEN cDNA E030030I06 gene

chr13_+_23752267 0.399 ENSMUST00000091703.2
Hist1h3b
histone cluster 1, H3b
chr5_+_149184678 0.397 ENSMUST00000139474.1
ENSMUST00000117878.1
Uspl1

ubiquitin specific peptidase like 1

chr11_+_98026695 0.384 ENSMUST00000092425.4
Rpl19
ribosomal protein L19
chr2_+_121456963 0.382 ENSMUST00000126764.1
Hypk
huntingtin interacting protein K
chr2_-_9883993 0.375 ENSMUST00000114915.2
9230102O04Rik
RIKEN cDNA 9230102O04 gene
chr10_-_6980376 0.366 ENSMUST00000105617.1
Ipcef1
interaction protein for cytohesin exchange factors 1
chr1_+_44551483 0.358 ENSMUST00000074525.3
Gulp1
GULP, engulfment adaptor PTB domain containing 1
chr19_-_47919269 0.357 ENSMUST00000095998.5
Itprip
inositol 1,4,5-triphosphate receptor interacting protein
chr16_-_76403673 0.343 ENSMUST00000052867.7
Gm9843
predicted gene 9843
chrM_+_7759 0.327 ENSMUST00000082407.1
ENSMUST00000082408.1
mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr4_-_133968611 0.321 ENSMUST00000102552.1
Hmgn2
high mobility group nucleosomal binding domain 2
chr4_-_141053704 0.320 ENSMUST00000102491.3
Crocc
ciliary rootlet coiled-coil, rootletin
chr11_+_78322965 0.316 ENSMUST00000017534.8
Aldoc
aldolase C, fructose-bisphosphate
chr10_+_128225830 0.310 ENSMUST00000026455.7
Mip
major intrinsic protein of eye lens fiber
chrX_-_23285532 0.307 ENSMUST00000115319.2
Klhl13
kelch-like 13
chr19_+_43752996 0.305 ENSMUST00000026199.7
ENSMUST00000112047.3
ENSMUST00000153295.1
Cutc


cutC copper transporter homolog (E.coli)


chr2_-_30093642 0.302 ENSMUST00000102865.4
Zdhhc12
zinc finger, DHHC domain containing 12
chr8_+_78509319 0.280 ENSMUST00000034111.8
Slc10a7
solute carrier family 10 (sodium/bile acid cotransporter family), member 7
chr8_+_13405080 0.271 ENSMUST00000033827.7
Grk1
G protein-coupled receptor kinase 1
chr19_+_36083696 0.264 ENSMUST00000025714.7
Rpp30
ribonuclease P/MRP 30 subunit
chr2_-_30093607 0.262 ENSMUST00000081838.6
Zdhhc12
zinc finger, DHHC domain containing 12
chrX_+_169879596 0.223 ENSMUST00000112105.1
ENSMUST00000078947.5
Mid1

midline 1

chr13_+_3361029 0.215 ENSMUST00000179981.1
Gm16505
predicted gene 16505
chr15_-_74734313 0.215 ENSMUST00000023260.3
Lypd2
Ly6/Plaur domain containing 2
chr14_-_54617993 0.192 ENSMUST00000022803.4
Psmb5
proteasome (prosome, macropain) subunit, beta type 5
chr2_-_73486456 0.180 ENSMUST00000141264.1
Wipf1
WAS/WASL interacting protein family, member 1
chr5_-_96161990 0.160 ENSMUST00000155901.1
Cnot6l
CCR4-NOT transcription complex, subunit 6-like
chr10_+_80292453 0.151 ENSMUST00000068408.7
ENSMUST00000062674.6
Rps15

ribosomal protein S15

chr19_+_8617991 0.142 ENSMUST00000010250.2
Slc22a6
solute carrier family 22 (organic anion transporter), member 6
chr19_+_46056539 0.142 ENSMUST00000111899.1
ENSMUST00000099392.3
ENSMUST00000062322.4
Pprc1


peroxisome proliferative activated receptor, gamma, coactivator-related 1


chr4_-_139833524 0.140 ENSMUST00000030508.7
Pax7
paired box gene 7
chr7_+_126976338 0.130 ENSMUST00000032920.3
Cdipt
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)
chr2_-_51972990 0.116 ENSMUST00000145481.1
ENSMUST00000112705.2
Nmi

N-myc (and STAT) interactor

chr1_-_92473801 0.111 ENSMUST00000027478.6
Ndufa10
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10
chr5_-_134456702 0.104 ENSMUST00000073161.5
ENSMUST00000171794.2
ENSMUST00000111245.2
ENSMUST00000100654.3
ENSMUST00000167084.2
ENSMUST00000100652.3
ENSMUST00000100650.3
ENSMUST00000074114.5
Gtf2ird1







general transcription factor II I repeat domain-containing 1







chr1_+_44551650 0.103 ENSMUST00000160854.1
Gulp1
GULP, engulfment adaptor PTB domain containing 1
chr11_+_23256566 0.094 ENSMUST00000136235.1
Xpo1
exportin 1, CRM1 homolog (yeast)
chr2_+_102658640 0.092 ENSMUST00000080210.3
Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr4_-_129742275 0.085 ENSMUST00000066257.5
Khdrbs1
KH domain containing, RNA binding, signal transduction associated 1
chr11_+_109649376 0.083 ENSMUST00000106677.1
Prkar1a
protein kinase, cAMP dependent regulatory, type I, alpha
chr2_+_91259822 0.077 ENSMUST00000138470.1
Pacsin3
protein kinase C and casein kinase substrate in neurons 3
chr11_-_5099036 0.070 ENSMUST00000102930.3
Ewsr1
Ewing sarcoma breakpoint region 1
chrX_+_7728439 0.063 ENSMUST00000033489.7
Praf2
PRA1 domain family 2
chr11_-_5099223 0.053 ENSMUST00000079949.6
Ewsr1
Ewing sarcoma breakpoint region 1
chr6_+_3993776 0.050 ENSMUST00000031673.5
Gngt1
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr11_-_5099053 0.050 ENSMUST00000093365.5
ENSMUST00000073308.4
Ewsr1

Ewing sarcoma breakpoint region 1

chrX_+_74424632 0.045 ENSMUST00000114129.2
ENSMUST00000132749.1
Ikbkg

inhibitor of kappaB kinase gamma

chr19_-_53371766 0.034 ENSMUST00000086887.1
Gm10197
predicted gene 10197
chr7_+_101969796 0.032 ENSMUST00000084852.5
Numa1
nuclear mitotic apparatus protein 1
chr16_-_4213404 0.031 ENSMUST00000023165.6
Crebbp
CREB binding protein
chr19_-_43752924 0.027 ENSMUST00000045562.5
Cox15
cytochrome c oxidase assembly protein 15
chr14_+_99298652 0.027 ENSMUST00000005279.6
Klf5
Kruppel-like factor 5
chr1_-_155232710 0.024 ENSMUST00000035914.3
BC034090
cDNA sequence BC034090
chr11_-_103954015 0.023 ENSMUST00000103075.4
Nsf
N-ethylmaleimide sensitive fusion protein
chr2_+_102659213 0.018 ENSMUST00000111213.1
Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr2_-_51973219 0.013 ENSMUST00000028314.2
Nmi
N-myc (and STAT) interactor
chrX_+_48623737 0.012 ENSMUST00000114936.1
Slc25a14
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr7_-_127725616 0.011 ENSMUST00000076091.2
Ctf2
cardiotrophin 2
chr1_+_178187417 0.010 ENSMUST00000161075.1
ENSMUST00000027783.7
Desi2

desumoylating isopeptidase 2


Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0032053 ciliary basal body organization(GO:0032053)
0.3 0.8 GO:0032650 regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730) cardiac cell fate determination(GO:0060913)
0.3 1.5 GO:0006570 tyrosine metabolic process(GO:0006570)
0.2 0.9 GO:2000705 regulation of dense core granule biogenesis(GO:2000705)
0.2 0.5 GO:0048687 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
0.2 1.0 GO:0086028 bundle of His cell to Purkinje myocyte signaling(GO:0086028) bundle of His cell action potential(GO:0086043)
0.2 0.6 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
0.1 0.4 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
0.1 0.6 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 0.5 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.1 0.4 GO:0030576 Cajal body organization(GO:0030576)
0.1 0.3 GO:0016056 photoreceptor cell morphogenesis(GO:0008594) rhodopsin mediated signaling pathway(GO:0016056) post-embryonic retina morphogenesis in camera-type eye(GO:0060060)
0.1 0.9 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.1 0.5 GO:0002681 somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153)
0.1 2.1 GO:0046677 response to antibiotic(GO:0046677)
0.0 1.5 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.1 GO:0015747 urate transport(GO:0015747)
0.0 0.3 GO:0032782 bile acid secretion(GO:0032782)
0.0 0.1 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.0 0.1 GO:1902524 interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.0 0.3 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.1 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241)
0.0 0.2 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.0 0.2 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.1 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.3 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.0 0.1 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.0 0.6 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.2 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0 0.1 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.0 0.7 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.5 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.3 GO:0055070 copper ion homeostasis(GO:0055070)
0.0 0.0 GO:0045358 negative regulation of interferon-beta biosynthetic process(GO:0045358)
0.0 1.0 GO:0009060 aerobic respiration(GO:0009060)
0.0 0.4 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.0 0.3 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.0 0.1 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 0.3 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.1 2.3 GO:0005652 nuclear lamina(GO:0005652)
0.1 2.1 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.1 1.3 GO:0035253 ciliary rootlet(GO:0035253)
0.1 1.5 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.7 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.9 GO:0097470 ribbon synapse(GO:0097470)
0.0 1.5 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.3 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 0.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.2 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.3 GO:0005921 gap junction(GO:0005921)
0.0 0.5 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 1.0 GO:0014704 intercalated disc(GO:0014704)
0.0 0.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.1 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.3 1.3 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.1 0.4 GO:0070140 isopeptidase activity(GO:0070122) ubiquitin-like protein-specific isopeptidase activity(GO:0070138) SUMO-specific isopeptidase activity(GO:0070140)
0.1 0.5 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.1 1.5 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 0.6 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 0.9 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.1 0.5 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.1 0.3 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.1 0.9 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.1 0.4 GO:1990932 5.8S rRNA binding(GO:1990932)
0.1 0.4 GO:0031432 titin binding(GO:0031432)
0.1 0.5 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.1 0.3 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 0.6 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 1.0 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.4 GO:0015037 peptide disulfide oxidoreductase activity(GO:0015037)
0.0 0.1 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0 0.5 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 0.3 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.8 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 1.5 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 1.1 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.3 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 0.8 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.6 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.1 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.1 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID_CONE_PATHWAY Visual signal transduction: Cones
0.0 0.8 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.1 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.0 1.4 WNT_SIGNALING Genes related to Wnt-mediated signal transduction

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 REACTOME_INCRETIN_SYNTHESIS_SECRETION_AND_INACTIVATION Genes involved in Incretin Synthesis, Secretion, and Inactivation
0.0 0.3 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 1.5 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.1 REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 1.0 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.5 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.1 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway