Motif ID: Aire

Z-value: 0.943


Transcription factors associated with Aire:

Gene SymbolEntrez IDGene Name
Aire ENSMUSG00000000731.9 Aire



Activity profile for motif Aire.

activity profile for motif Aire


Sorted Z-values histogram for motif Aire

Sorted Z-values for motif Aire



Network of associatons between targets according to the STRING database.



First level regulatory network of Aire

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_61185558 18.216 ENSMUST00000166381.1
Cdr1
cerebellar degeneration related antigen 1
chr10_+_123264076 3.159 ENSMUST00000050756.7
Fam19a2
family with sequence similarity 19, member A2
chr13_-_110280103 2.678 ENSMUST00000167824.1
Rab3c
RAB3C, member RAS oncogene family
chr12_-_78983476 1.973 ENSMUST00000070174.7
Tmem229b
transmembrane protein 229B
chr16_+_36875119 1.828 ENSMUST00000135406.1
ENSMUST00000114812.1
ENSMUST00000134616.1
ENSMUST00000023534.6
Golgb1


Golgb1
golgi autoantigen, golgin subfamily b, macrogolgin 1


golgi autoantigen, golgin subfamily b, macrogolgin 1
chr19_-_28963863 1.789 ENSMUST00000161813.1
4430402I18Rik
RIKEN cDNA 4430402I18 gene
chr10_+_86021961 1.721 ENSMUST00000130320.1
Fbxo7
F-box protein 7
chr3_-_116968969 1.586 ENSMUST00000143611.1
ENSMUST00000040097.7
Palmd

palmdelphin

chr8_+_69808672 1.371 ENSMUST00000036074.8
ENSMUST00000123453.1
Gmip

Gem-interacting protein

chr7_-_14562171 1.186 ENSMUST00000181796.1
Vmn1r90
vomeronasal 1 receptor 90
chr14_+_76476913 1.137 ENSMUST00000140251.2
Tsc22d1
TSC22 domain family, member 1
chr18_+_37400845 1.117 ENSMUST00000057228.1
Pcdhb9
protocadherin beta 9
chr8_+_64947177 1.096 ENSMUST00000079896.7
ENSMUST00000026595.5
Tmem192

transmembrane protein 192

chr9_-_97111117 1.080 ENSMUST00000085206.4
Slc25a36
solute carrier family 25, member 36
chr2_+_55435918 0.991 ENSMUST00000067101.3
Kcnj3
potassium inwardly-rectifying channel, subfamily J, member 3
chr19_+_34217588 0.975 ENSMUST00000119603.1
Stambpl1
STAM binding protein like 1
chr5_-_84417359 0.966 ENSMUST00000113401.1
Epha5
Eph receptor A5
chr4_-_46566432 0.937 ENSMUST00000030021.7
ENSMUST00000107757.1
Coro2a

coronin, actin binding protein 2A

chr2_+_164948219 0.932 ENSMUST00000017881.2
Mmp9
matrix metallopeptidase 9
chr2_-_134644079 0.825 ENSMUST00000110119.1
Tmx4
thioredoxin-related transmembrane protein 4
chr10_-_81014902 0.772 ENSMUST00000126317.1
ENSMUST00000092285.3
ENSMUST00000117805.1
Gng7


guanine nucleotide binding protein (G protein), gamma 7


chr8_-_4216912 0.690 ENSMUST00000177491.1
BC068157
cDNA sequence BC068157
chr17_+_35236556 0.689 ENSMUST00000068261.8
Atp6v1g2
ATPase, H+ transporting, lysosomal V1 subunit G2
chr11_-_115627948 0.646 ENSMUST00000154623.1
ENSMUST00000106503.3
ENSMUST00000141614.1
Slc25a19


solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19


chr5_+_43672289 0.645 ENSMUST00000156034.1
Cc2d2a
coiled-coil and C2 domain containing 2A
chr8_-_4217133 0.643 ENSMUST00000175906.1
BC068157
cDNA sequence BC068157
chr3_-_62506970 0.639 ENSMUST00000029336.4
Dhx36
DEAH (Asp-Glu-Ala-His) box polypeptide 36
chr9_-_53610329 0.636 ENSMUST00000034547.5
Acat1
acetyl-Coenzyme A acetyltransferase 1
chr7_-_127895578 0.630 ENSMUST00000033074.6
Vkorc1
vitamin K epoxide reductase complex, subunit 1
chr17_+_22689771 0.618 ENSMUST00000055305.8
Gm9805
predicted gene 9805
chr16_-_91618986 0.615 ENSMUST00000143058.1
ENSMUST00000049244.8
ENSMUST00000169982.1
ENSMUST00000133731.1
Dnajc28



DnaJ (Hsp40) homolog, subfamily C, member 28



chr1_+_65186727 0.615 ENSMUST00000097707.4
ENSMUST00000081154.7
Pikfyve

phosphoinositide kinase, FYVE finger containing

chr5_+_130369420 0.612 ENSMUST00000086029.3
Caln1
calneuron 1
chr10_+_58446845 0.604 ENSMUST00000003310.5
Ranbp2
RAN binding protein 2
chr12_+_36157124 0.595 ENSMUST00000041640.3
Ankmy2
ankyrin repeat and MYND domain containing 2
chr5_-_105343929 0.594 ENSMUST00000183149.1
Gbp11
guanylate binding protein 11
chr12_+_84052114 0.592 ENSMUST00000120927.1
Acot3
acyl-CoA thioesterase 3
chr5_+_140735526 0.583 ENSMUST00000120630.2
Amz1
archaelysin family metallopeptidase 1
chr3_+_89715016 0.528 ENSMUST00000098924.2
Adar
adenosine deaminase, RNA-specific
chr18_+_37725706 0.521 ENSMUST00000066149.6
Pcdhga9
protocadherin gamma subfamily A, 9
chr9_+_109054839 0.518 ENSMUST00000154184.1
Shisa5
shisa homolog 5 (Xenopus laevis)
chr7_+_45896941 0.510 ENSMUST00000069772.7
ENSMUST00000107716.1
Tmem143

transmembrane protein 143

chr3_-_89411781 0.503 ENSMUST00000107429.3
ENSMUST00000129308.2
ENSMUST00000107426.1
ENSMUST00000050398.4
ENSMUST00000162701.1
Flad1




RFad1, flavin adenine dinucleotide synthetase, homolog (yeast)




chr15_+_101266839 0.477 ENSMUST00000023779.6
Nr4a1
nuclear receptor subfamily 4, group A, member 1
chr2_+_175283298 0.473 ENSMUST00000098998.3
Gm14440
predicted gene 14440
chr11_-_69695802 0.460 ENSMUST00000108649.1
ENSMUST00000174159.1
ENSMUST00000181810.1
BC096441

Tnfsf12
cDNA sequence BC096441

tumor necrosis factor (ligand) superfamily, member 12
chr14_+_124005355 0.417 ENSMUST00000166105.1
Gm17615
predicted gene, 17615
chr2_-_165400398 0.414 ENSMUST00000029213.4
Ocstamp
osteoclast stimulatory transmembrane protein
chr5_-_113310697 0.400 ENSMUST00000154248.1
Sgsm1
small G protein signaling modulator 1
chr14_-_18894255 0.397 ENSMUST00000124353.1
Ube2e2
ubiquitin-conjugating enzyme E2E 2
chr5_+_24100578 0.393 ENSMUST00000030841.5
ENSMUST00000163409.1
Klhl7

kelch-like 7

chr7_+_45897429 0.389 ENSMUST00000140243.1
Tmem143
transmembrane protein 143
chr8_+_111643425 0.388 ENSMUST00000077791.6
Zfp1
zinc finger protein 1
chr4_-_19570073 0.381 ENSMUST00000029885.4
Cpne3
copine III
chr14_+_21481428 0.371 ENSMUST00000182996.1
Kat6b
K(lysine) acetyltransferase 6B
chr13_+_49504774 0.366 ENSMUST00000051504.7
Ecm2
extracellular matrix protein 2, female organ and adipocyte specific
chr2_+_176431829 0.335 ENSMUST00000172025.1
Gm14435
predicted gene 14435
chr2_-_134644125 0.331 ENSMUST00000038228.4
Tmx4
thioredoxin-related transmembrane protein 4
chr13_-_62371936 0.323 ENSMUST00000107989.3
Gm3604
predicted gene 3604
chrX_-_38576166 0.317 ENSMUST00000050083.5
Cul4b
cullin 4B
chr2_+_172248492 0.292 ENSMUST00000038532.1
Mc3r
melanocortin 3 receptor
chr12_-_36156781 0.281 ENSMUST00000020856.4
Bzw2
basic leucine zipper and W2 domains 2
chr2_-_121473993 0.274 ENSMUST00000056732.3
Mfap1b
microfibrillar-associated protein 1B
chr2_-_94010729 0.228 ENSMUST00000040005.6
ENSMUST00000126378.1
Alkbh3

alkB, alkylation repair homolog 3 (E. coli)

chr16_-_36874806 0.190 ENSMUST00000075946.5
Eaf2
ELL associated factor 2
chr4_+_154869585 0.186 ENSMUST00000079269.7
ENSMUST00000163732.1
ENSMUST00000080559.6
Mmel1


membrane metallo-endopeptidase-like 1


chr10_+_53337686 0.180 ENSMUST00000046221.6
ENSMUST00000163319.1
Pln

phospholamban

chr6_+_126939957 0.177 ENSMUST00000032497.3
D6Wsu163e
DNA segment, Chr 6, Wayne State University 163, expressed
chr9_-_53667429 0.161 ENSMUST00000166367.1
ENSMUST00000034529.7
Cul5

cullin 5

chr11_-_69696058 0.157 ENSMUST00000094070.4
ENSMUST00000180587.1
BC096441
Tnfsf12
cDNA sequence BC096441
tumor necrosis factor (ligand) superfamily, member 12
chr19_+_3323301 0.151 ENSMUST00000025835.4
Cpt1a
carnitine palmitoyltransferase 1a, liver
chr9_-_113708209 0.145 ENSMUST00000111861.3
ENSMUST00000035086.6
Pdcd6ip

programmed cell death 6 interacting protein

chr10_+_52358767 0.141 ENSMUST00000180473.1
Gm26741
predicted gene, 26741
chr5_+_29378604 0.134 ENSMUST00000181005.1
4632411P08Rik
RIKEN cDNA 4632411P08 gene
chr7_-_141434532 0.129 ENSMUST00000133021.1
ENSMUST00000106007.3
ENSMUST00000150026.1
ENSMUST00000133206.2
Slc25a22



solute carrier family 25 (mitochondrial carrier, glutamate), member 22



chr8_-_31739763 0.123 ENSMUST00000178878.1
Gm5117
predicted gene 5117
chr7_+_60155538 0.114 ENSMUST00000057611.4
Gm7367
predicted pseudogene 7367
chr4_+_42714926 0.101 ENSMUST00000178454.1
Gm21955
predicted gene, 21955
chrX_-_38576189 0.080 ENSMUST00000115118.1
Cul4b
cullin 4B
chr7_-_103741322 0.067 ENSMUST00000051346.2
Olfr629
olfactory receptor 629
chr2_-_94010807 0.063 ENSMUST00000111240.1
Alkbh3
alkB, alkylation repair homolog 3 (E. coli)
chr17_-_6961156 0.063 ENSMUST00000063683.6
Tagap1
T cell activation GTPase activating protein 1
chr11_-_28584260 0.059 ENSMUST00000093253.3
ENSMUST00000109502.2
ENSMUST00000042534.8
Ccdc85a


coiled-coil domain containing 85A


chr3_+_88835231 0.053 ENSMUST00000107498.2
Gon4l
gon-4-like (C.elegans)
chr1_+_44119952 0.050 ENSMUST00000114709.2
Bivm
basic, immunoglobulin-like variable motif containing
chr7_-_121981669 0.049 ENSMUST00000057576.7
Cog7
component of oligomeric golgi complex 7
chr15_+_10981747 0.049 ENSMUST00000070877.5
Amacr
alpha-methylacyl-CoA racemase
chr8_-_109962127 0.049 ENSMUST00000001722.7
ENSMUST00000051430.6
Marveld3

MARVEL (membrane-associating) domain containing 3

chr4_+_11758147 0.048 ENSMUST00000029871.5
ENSMUST00000108303.1
Cdh17

cadherin 17

chr12_+_4843303 0.024 ENSMUST00000053034.4
BC068281
cDNA sequence BC068281
chr9_-_108263706 0.015 ENSMUST00000171412.1
Dag1
dystroglycan 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:0072531 pyrimidine-containing compound transmembrane transport(GO:0072531)
0.2 0.6 GO:0030974 thiamine pyrophosphate transport(GO:0030974)
0.2 1.7 GO:1903207 neuron death in response to hydrogen peroxide(GO:0036476) regulation of hydrogen peroxide-induced neuron death(GO:1903207) negative regulation of hydrogen peroxide-induced neuron death(GO:1903208)
0.2 0.6 GO:0006550 isoleucine catabolic process(GO:0006550) acetyl-CoA catabolic process(GO:0046356) ketone body catabolic process(GO:0046952)
0.2 0.6 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.2 0.6 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.2 0.9 GO:2001268 positive regulation of receptor binding(GO:1900122) negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001268)
0.2 0.5 GO:1900369 negative regulation of RNA interference(GO:1900369)
0.2 0.5 GO:0042726 flavin-containing compound metabolic process(GO:0042726)
0.1 0.6 GO:0032788 saturated monocarboxylic acid metabolic process(GO:0032788) unsaturated monocarboxylic acid metabolic process(GO:0032789)
0.1 1.0 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.1 0.4 GO:0034241 positive regulation of macrophage fusion(GO:0034241) regulation of osteoclast proliferation(GO:0090289)
0.1 0.6 GO:0090669 telomerase RNA stabilization(GO:0090669)
0.1 0.6 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.1 1.0 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.1 0.5 GO:0071376 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.1 0.4 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.1 0.8 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1 0.3 GO:0035552 oxidative single-stranded DNA demethylation(GO:0035552) oxidative single-stranded RNA demethylation(GO:0035553)
0.0 0.4 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.1 GO:0044837 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
0.0 0.6 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0 2.3 GO:0019882 antigen processing and presentation(GO:0019882)
0.0 0.6 GO:0032288 myelin assembly(GO:0032288)
0.0 0.2 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0 1.3 GO:0007606 sensory perception of chemical stimulus(GO:0007606)
0.0 0.2 GO:0086023 adrenergic receptor signaling pathway involved in heart process(GO:0086023)
0.0 0.2 GO:0070914 UV-damage excision repair(GO:0070914)
0.0 0.0 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.0 0.2 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
0.0 0.9 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 0.3 GO:0045475 locomotor rhythm(GO:0045475)
0.0 0.2 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.7 GO:1990037 Lewy body core(GO:1990037)
0.1 0.5 GO:0044530 supraspliceosomal complex(GO:0044530)
0.1 0.4 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0 0.7 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.6 GO:0036038 MKS complex(GO:0036038)
0.0 0.7 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0 0.6 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 1.8 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.2 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 0.4 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.3 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.6 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.1 GO:0090543 Flemming body(GO:0090543)
0.0 2.7 GO:0008021 synaptic vesicle(GO:0008021)
0.0 0.4 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 1.0 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 1.0 GO:0005791 rough endoplasmic reticulum(GO:0005791)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.2 0.5 GO:0003692 left-handed Z-DNA binding(GO:0003692)
0.1 0.4 GO:0070052 collagen V binding(GO:0070052)
0.1 1.0 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.1 2.7 GO:0031489 myosin V binding(GO:0031489)
0.1 0.6 GO:0015234 thiamine transmembrane transporter activity(GO:0015234)
0.1 0.6 GO:0016453 acetyl-CoA C-acetyltransferase activity(GO:0003985) C-acetyltransferase activity(GO:0016453)
0.1 0.3 GO:0004980 melanocortin receptor activity(GO:0004977) melanocyte-stimulating hormone receptor activity(GO:0004980)
0.1 0.3 GO:0051747 cytosine C-5 DNA demethylase activity(GO:0051747)
0.1 0.6 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.1 0.6 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.1 0.4 GO:0042296 ISG15 transferase activity(GO:0042296)
0.1 0.7 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 1.1 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 0.1 GO:0031871 proteinase activated receptor binding(GO:0031871)
0.0 0.6 GO:0048038 quinone binding(GO:0048038)
0.0 1.1 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)
0.0 0.6 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 0.9 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.2 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.0 0.2 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 0.6 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.5 GO:0070566 adenylyltransferase activity(GO:0070566)
0.0 0.6 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 0.0 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.0 0.5 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.5 GO:0050699 WW domain binding(GO:0050699)
0.0 1.7 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.1 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 1.7 GO:0008237 metallopeptidase activity(GO:0008237)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.9 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 1.2 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 1.0 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.5 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.1 0.6 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 1.8 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.6 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.7 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 0.6 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.6 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.5 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.5 REACTOME_PIP3_ACTIVATES_AKT_SIGNALING Genes involved in PIP3 activates AKT signaling