Motif ID: Stat2

Z-value: 2.943


Transcription factors associated with Stat2:

Gene SymbolEntrez IDGene Name
Stat2 ENSMUSG00000040033.9 Stat2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Stat2mm10_v2_chr10_+_128270546_1282705770.865.8e-06Click!


Activity profile for motif Stat2.

activity profile for motif Stat2


Sorted Z-values histogram for motif Stat2

Sorted Z-values for motif Stat2



Network of associatons between targets according to the STRING database.



First level regulatory network of Stat2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_66812593 18.907 ENSMUST00000100572.3
Sla
src-like adaptor
chr16_+_23609895 17.959 ENSMUST00000038423.5
Rtp4
receptor transporter protein 4
chr1_-_173942445 13.031 ENSMUST00000042228.8
ENSMUST00000081216.5
ENSMUST00000129829.1
ENSMUST00000123708.1
ENSMUST00000111210.2
Ifi203



Mndal
interferon activated gene 203



myeloid nuclear differentiation antigen like
chr6_+_90550789 12.979 ENSMUST00000130418.1
ENSMUST00000032175.8
Aldh1l1

aldehyde dehydrogenase 1 family, member L1

chr10_+_13966268 10.578 ENSMUST00000015645.4
Hivep2
human immunodeficiency virus type I enhancer binding protein 2
chr12_-_78980758 10.106 ENSMUST00000174072.1
Tmem229b
transmembrane protein 229B
chr1_+_153751946 9.453 ENSMUST00000183241.1
Rnasel
ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)
chr11_+_70459940 8.784 ENSMUST00000147289.1
ENSMUST00000126105.1
Zmynd15

zinc finger, MYND-type containing 15

chr6_-_13839916 8.354 ENSMUST00000060442.7
Gpr85
G protein-coupled receptor 85
chr5_+_107497762 7.864 ENSMUST00000152474.1
ENSMUST00000060553.7
A830010M20Rik

RIKEN cDNA A830010M20 gene

chr12_+_103434211 7.651 ENSMUST00000079294.5
ENSMUST00000076788.5
ENSMUST00000076702.5
ENSMUST00000066701.6
ENSMUST00000085065.5
ENSMUST00000140838.1
Ifi27





interferon, alpha-inducible protein 27





chr1_+_153751859 7.492 ENSMUST00000182538.1
Rnasel
ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)
chr2_+_4559742 6.917 ENSMUST00000176828.1
Frmd4a
FERM domain containing 4A
chr17_+_86167777 6.675 ENSMUST00000097275.2
Prkce
protein kinase C, epsilon
chr3_-_107760221 6.662 ENSMUST00000153114.1
ENSMUST00000118593.1
ENSMUST00000120243.1
Csf1


colony stimulating factor 1 (macrophage)


chr5_+_107497718 6.629 ENSMUST00000112671.2
A830010M20Rik
RIKEN cDNA A830010M20 gene
chr11_-_70459957 6.359 ENSMUST00000019064.2
Cxcl16
chemokine (C-X-C motif) ligand 16
chr7_-_141010759 6.296 ENSMUST00000026565.6
Ifitm3
interferon induced transmembrane protein 3
chr1_-_170110491 6.251 ENSMUST00000027985.2
Ddr2
discoidin domain receptor family, member 2
chr1_+_153749496 6.173 ENSMUST00000182722.1
Rnasel
ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)
chr16_+_42907563 6.063 ENSMUST00000151244.1
ENSMUST00000114694.2
Zbtb20

zinc finger and BTB domain containing 20

chr16_+_43363855 5.985 ENSMUST00000156367.1
Zbtb20
zinc finger and BTB domain containing 20
chr12_+_26469204 5.901 ENSMUST00000020969.3
Cmpk2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chrX_+_41401128 5.753 ENSMUST00000115103.2
Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chr9_+_20868628 5.440 ENSMUST00000043911.7
A230050P20Rik
RIKEN cDNA A230050P20 gene
chrX_+_41401304 5.425 ENSMUST00000076349.5
Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chr16_+_26581704 5.403 ENSMUST00000096129.2
ENSMUST00000166294.2
ENSMUST00000174202.1
ENSMUST00000023156.6
Il1rap



interleukin 1 receptor accessory protein



chr10_+_39612934 5.313 ENSMUST00000019987.6
Traf3ip2
TRAF3 interacting protein 2
chr3_+_89730735 5.256 ENSMUST00000107405.2
ENSMUST00000029563.8
ENSMUST00000121094.1
ENSMUST00000118341.1
Adar



adenosine deaminase, RNA-specific



chr16_+_43235856 5.214 ENSMUST00000146708.1
Zbtb20
zinc finger and BTB domain containing 20
chr16_+_43364145 5.102 ENSMUST00000148775.1
Zbtb20
zinc finger and BTB domain containing 20
chr13_+_42866247 4.991 ENSMUST00000131942.1
Phactr1
phosphatase and actin regulator 1
chr1_+_153749414 4.922 ENSMUST00000086209.3
Rnasel
ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)
chr12_-_79007276 4.891 ENSMUST00000056660.6
ENSMUST00000174721.1
Tmem229b

transmembrane protein 229B

chr11_+_29463735 4.869 ENSMUST00000155854.1
Ccdc88a
coiled coil domain containing 88A
chr4_-_156200818 4.756 ENSMUST00000085425.4
Isg15
ISG15 ubiquitin-like modifier
chr19_+_29367447 4.749 ENSMUST00000016640.7
Cd274
CD274 antigen
chr8_-_84773381 4.648 ENSMUST00000109764.1
Nfix
nuclear factor I/X
chr7_-_78578308 4.484 ENSMUST00000039431.7
Ntrk3
neurotrophic tyrosine kinase, receptor, type 3
chr2_-_36104060 4.334 ENSMUST00000112961.3
ENSMUST00000112966.3
Lhx6

LIM homeobox protein 6

chr2_-_45110336 4.316 ENSMUST00000028229.6
ENSMUST00000152232.1
Zeb2

zinc finger E-box binding homeobox 2

chr18_+_69593361 4.304 ENSMUST00000114978.2
ENSMUST00000114977.1
Tcf4

transcription factor 4

chr5_-_134229581 4.303 ENSMUST00000111275.1
ENSMUST00000016094.6
ENSMUST00000144086.1
Ncf1


neutrophil cytosolic factor 1


chr13_+_109260481 4.213 ENSMUST00000153234.1
Pde4d
phosphodiesterase 4D, cAMP specific
chr18_+_61045139 4.134 ENSMUST00000025522.4
ENSMUST00000115274.1
Pdgfrb

platelet derived growth factor receptor, beta polypeptide

chr16_-_22439719 4.106 ENSMUST00000079601.6
Etv5
ets variant gene 5
chr2_-_167062607 4.089 ENSMUST00000128676.1
Znfx1
zinc finger, NFX1-type containing 1
chr1_-_85598796 4.029 ENSMUST00000093508.6
Sp110
Sp110 nuclear body protein
chr11_+_72689997 3.949 ENSMUST00000155998.1
Ankfy1
ankyrin repeat and FYVE domain containing 1
chr6_+_127446819 3.842 ENSMUST00000112191.1
Parp11
poly (ADP-ribose) polymerase family, member 11
chr18_+_37400845 3.818 ENSMUST00000057228.1
Pcdhb9
protocadherin beta 9
chr11_+_119393060 3.799 ENSMUST00000131035.2
ENSMUST00000093902.5
Rnf213

ring finger protein 213

chr7_+_80860909 3.752 ENSMUST00000132163.1
ENSMUST00000147125.1
Zscan2

zinc finger and SCAN domain containing 2

chr3_-_32616479 3.665 ENSMUST00000108234.1
ENSMUST00000155737.1
Gnb4

guanine nucleotide binding protein (G protein), beta 4

chr19_-_29367294 3.653 ENSMUST00000138051.1
Plgrkt
plasminogen receptor, C-terminal lysine transmembrane protein
chr11_+_31872100 3.599 ENSMUST00000020543.6
ENSMUST00000109412.2
Cpeb4

cytoplasmic polyadenylation element binding protein 4

chr1_+_66175272 3.494 ENSMUST00000156636.2
Map2
microtubule-associated protein 2
chr4_+_45972233 3.479 ENSMUST00000102929.1
Tdrd7
tudor domain containing 7
chr10_-_30655859 3.469 ENSMUST00000092610.4
Ncoa7
nuclear receptor coactivator 7
chr2_-_167062981 3.467 ENSMUST00000048988.7
Znfx1
zinc finger, NFX1-type containing 1
chr1_+_132008285 3.406 ENSMUST00000146432.1
Elk4
ELK4, member of ETS oncogene family
chrX_-_139998519 3.382 ENSMUST00000113007.1
ENSMUST00000033810.7
ENSMUST00000113011.2
ENSMUST00000087400.5
Rbm41



RNA binding motif protein 41



chr2_-_173276144 3.362 ENSMUST00000139306.1
Pmepa1
prostate transmembrane protein, androgen induced 1
chr16_-_44139630 3.326 ENSMUST00000137557.1
ENSMUST00000147025.1
Atp6v1a

ATPase, H+ transporting, lysosomal V1 subunit A

chr9_+_118040576 3.130 ENSMUST00000134433.1
Azi2
5-azacytidine induced gene 2
chr1_+_171018920 3.122 ENSMUST00000078825.4
Fcgr4
Fc receptor, IgG, low affinity IV
chr9_+_19641224 3.114 ENSMUST00000079042.6
Zfp317
zinc finger protein 317
chr9_-_78443204 3.069 ENSMUST00000070742.7
ENSMUST00000034898.7
Mb21d1

Mab-21 domain containing 1

chr1_-_9748376 3.001 ENSMUST00000057438.6
Vcpip1
valosin containing protein (p97)/p47 complex interacting protein 1
chr8_+_88651341 2.980 ENSMUST00000109634.2
Nod2
nucleotide-binding oligomerization domain containing 2
chr5_-_73256555 2.946 ENSMUST00000101127.5
ENSMUST00000171179.1
Fryl
Fryl
furry homolog-like (Drosophila)
furry homolog-like (Drosophila)
chr6_+_86404336 2.925 ENSMUST00000113713.2
ENSMUST00000113708.1
Tia1

cytotoxic granule-associated RNA binding protein 1

chrX_-_95444789 2.898 ENSMUST00000084535.5
Amer1
APC membrane recruitment 1
chr13_+_14063776 2.896 ENSMUST00000129488.1
ENSMUST00000110536.1
ENSMUST00000110534.1
ENSMUST00000039538.8
ENSMUST00000110533.1
Arid4b




AT rich interactive domain 4B (RBP1-like)




chr14_-_63543931 2.867 ENSMUST00000058679.5
Mtmr9
myotubularin related protein 9
chr10_+_128270546 2.803 ENSMUST00000105238.3
ENSMUST00000085708.2
Stat2

signal transducer and activator of transcription 2

chr12_+_52699297 2.800 ENSMUST00000095737.3
Akap6
A kinase (PRKA) anchor protein 6
chr7_+_30121915 2.734 ENSMUST00000098596.3
ENSMUST00000153792.1
Zfp382

zinc finger protein 382

chr4_+_138972885 2.721 ENSMUST00000123636.1
ENSMUST00000043042.3
ENSMUST00000050949.2
Tmco4


transmembrane and coiled-coil domains 4


chr17_+_29660710 2.671 ENSMUST00000130423.1
Cmtr1
cap methyltransferase 1
chr2_-_132111440 2.661 ENSMUST00000128899.1
Slc23a2
solute carrier family 23 (nucleobase transporters), member 2
chr1_-_155972887 2.660 ENSMUST00000138762.1
ENSMUST00000124495.1
Cep350

centrosomal protein 350

chr11_+_88999376 2.601 ENSMUST00000100627.2
ENSMUST00000107896.3
ENSMUST00000000284.6
Trim25


tripartite motif-containing 25


chr15_+_79892436 2.590 ENSMUST00000175752.1
ENSMUST00000176325.1
Apobec3

apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3

chr8_-_122551316 2.581 ENSMUST00000067252.7
Piezo1
piezo-type mechanosensitive ion channel component 1
chr7_+_44836286 2.553 ENSMUST00000033015.7
Il4i1
interleukin 4 induced 1
chr7_-_46795661 2.512 ENSMUST00000123725.1
Hps5
Hermansky-Pudlak syndrome 5 homolog (human)
chr15_+_79892397 2.494 ENSMUST00000175714.1
ENSMUST00000109620.3
ENSMUST00000165537.1
Apobec3


apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3


chr1_-_156674290 2.463 ENSMUST00000079625.4
Tor3a
torsin family 3, member A
chr4_-_58911902 2.402 ENSMUST00000134848.1
ENSMUST00000107557.2
ENSMUST00000149301.1
AI314180


expressed sequence AI314180


chr1_+_85650008 2.383 ENSMUST00000054279.8
ENSMUST00000147552.1
ENSMUST00000153574.1
ENSMUST00000150967.1
Sp100



nuclear antigen Sp100



chr10_-_94944578 2.330 ENSMUST00000099337.3
Plxnc1
plexin C1
chr1_-_37496095 2.278 ENSMUST00000148047.1
ENSMUST00000143636.1
Mgat4a

mannoside acetylglucosaminyltransferase 4, isoenzyme A

chr7_-_141266415 2.257 ENSMUST00000106023.1
ENSMUST00000097952.2
ENSMUST00000026571.4
Irf7


interferon regulatory factor 7


chr12_+_90738201 2.245 ENSMUST00000181874.1
Gm26512
predicted gene, 26512
chr16_-_44139003 2.219 ENSMUST00000124102.1
Atp6v1a
ATPase, H+ transporting, lysosomal V1 subunit A
chr11_-_118401826 2.218 ENSMUST00000106290.3
ENSMUST00000043722.3
Lgals3bp

lectin, galactoside-binding, soluble, 3 binding protein

chr11_+_69846665 2.180 ENSMUST00000019605.2
Plscr3
phospholipid scramblase 3
chr11_-_47379405 2.133 ENSMUST00000077221.5
Sgcd
sarcoglycan, delta (dystrophin-associated glycoprotein)
chr8_-_105938384 2.101 ENSMUST00000034369.8
Psmb10
proteasome (prosome, macropain) subunit, beta type 10
chr1_-_52190901 2.037 ENSMUST00000156887.1
ENSMUST00000129107.1
Gls

glutaminase

chr9_+_32116040 2.001 ENSMUST00000174641.1
Arhgap32
Rho GTPase activating protein 32
chr6_+_57580992 1.997 ENSMUST00000031817.8
Herc6
hect domain and RLD 6
chr18_-_78142119 1.986 ENSMUST00000160639.1
Slc14a1
solute carrier family 14 (urea transporter), member 1
chr11_+_69846610 1.923 ENSMUST00000152566.1
ENSMUST00000108633.2
Plscr3

phospholipid scramblase 3

chr13_+_37345338 1.896 ENSMUST00000021860.5
Ly86
lymphocyte antigen 86
chr9_-_103761820 1.886 ENSMUST00000049452.8
Tmem108
transmembrane protein 108
chr1_-_184732616 1.876 ENSMUST00000048572.6
Hlx
H2.0-like homeobox
chr10_+_40629987 1.866 ENSMUST00000019977.7
Ddo
D-aspartate oxidase
chr3_+_94954075 1.865 ENSMUST00000107260.2
ENSMUST00000142311.1
ENSMUST00000137088.1
ENSMUST00000152869.1
ENSMUST00000107254.1
ENSMUST00000107253.1
Rfx5





regulatory factor X, 5 (influences HLA class II expression)





chrX_+_166238901 1.850 ENSMUST00000112235.1
Gpm6b
glycoprotein m6b
chr11_-_49051122 1.834 ENSMUST00000132768.1
ENSMUST00000101295.2
ENSMUST00000093152.1
9930111J21Rik2


RIKEN cDNA 9930111J21 gene 2


chr9_-_117252450 1.831 ENSMUST00000111773.3
ENSMUST00000068962.7
ENSMUST00000044901.7
Rbms3


RNA binding motif, single stranded interacting protein


chr4_-_46536096 1.827 ENSMUST00000102924.2
Trim14
tripartite motif-containing 14
chr9_-_48835932 1.810 ENSMUST00000093852.3
Zbtb16
zinc finger and BTB domain containing 16
chr9_+_118040509 1.755 ENSMUST00000133580.1
Azi2
5-azacytidine induced gene 2
chr3_+_114030532 1.735 ENSMUST00000123619.1
ENSMUST00000092155.5
Col11a1

collagen, type XI, alpha 1

chr11_-_121229095 1.723 ENSMUST00000137299.1
ENSMUST00000169393.1
BC017643

cDNA sequence BC017643

chr17_+_29660595 1.667 ENSMUST00000024816.6
Cmtr1
cap methyltransferase 1
chr17_+_33955812 1.648 ENSMUST00000025178.9
ENSMUST00000114330.2
Vps52

vacuolar protein sorting 52 (yeast)

chr7_+_46796088 1.645 ENSMUST00000006774.4
ENSMUST00000165031.1
Gtf2h1

general transcription factor II H, polypeptide 1

chr16_+_24393350 1.621 ENSMUST00000038053.6
Lpp
LIM domain containing preferred translocation partner in lipoma
chr14_+_55578123 1.605 ENSMUST00000174484.1
Psme1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr3_+_137671524 1.605 ENSMUST00000166899.2
Gm21962
predicted gene, 21962
chr19_-_6084873 1.578 ENSMUST00000160977.1
ENSMUST00000159859.1
Zfpl1

zinc finger like protein 1

chr6_-_39118211 1.551 ENSMUST00000038398.6
Parp12
poly (ADP-ribose) polymerase family, member 12
chr10_+_52358767 1.536 ENSMUST00000180473.1
Gm26741
predicted gene, 26741
chr1_+_143640664 1.524 ENSMUST00000038252.2
B3galt2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr15_-_76243401 1.497 ENSMUST00000165738.1
ENSMUST00000075689.6
Parp10

poly (ADP-ribose) polymerase family, member 10

chr17_+_36837123 1.485 ENSMUST00000179968.1
ENSMUST00000130367.1
ENSMUST00000130801.1
ENSMUST00000144182.1
ENSMUST00000123715.1
ENSMUST00000053434.8
Trim26





tripartite motif-containing 26





chr2_-_152332353 1.454 ENSMUST00000109847.2
Rbck1
RanBP-type and C3HC4-type zinc finger containing 1
chr18_+_37725706 1.451 ENSMUST00000066149.6
Pcdhga9
protocadherin gamma subfamily A, 9
chr2_+_155382186 1.448 ENSMUST00000134218.1
Trp53inp2
transformation related protein 53 inducible nuclear protein 2
chr2_+_91650116 1.438 ENSMUST00000111331.2
Arhgap1
Rho GTPase activating protein 1
chr2_-_51972990 1.419 ENSMUST00000145481.1
ENSMUST00000112705.2
Nmi

N-myc (and STAT) interactor

chr19_-_21472552 1.377 ENSMUST00000087600.3
Gda
guanine deaminase
chr18_+_38296635 1.376 ENSMUST00000072376.5
ENSMUST00000170811.1
Rnf14

ring finger protein 14

chr2_+_91650169 1.375 ENSMUST00000090614.4
Arhgap1
Rho GTPase activating protein 1
chr3_+_60501252 1.342 ENSMUST00000099087.2
Mbnl1
muscleblind-like 1 (Drosophila)
chr13_+_49504774 1.327 ENSMUST00000051504.7
Ecm2
extracellular matrix protein 2, female organ and adipocyte specific
chr16_+_8470763 1.313 ENSMUST00000046470.9
ENSMUST00000150790.1
ENSMUST00000142899.1
Mettl22


methyltransferase like 22


chr7_-_46795881 1.292 ENSMUST00000107653.1
ENSMUST00000107654.1
ENSMUST00000014562.7
ENSMUST00000152759.1
Hps5



Hermansky-Pudlak syndrome 5 homolog (human)



chr4_-_40239779 1.260 ENSMUST00000037907.6
Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr2_-_91649785 1.258 ENSMUST00000111333.1
Zfp408
zinc finger protein 408
chr19_+_7297658 1.258 ENSMUST00000170286.1
Gm17227
predicted gene 17227
chrX_-_38576166 1.181 ENSMUST00000050083.5
Cul4b
cullin 4B
chr11_-_48871344 1.177 ENSMUST00000049519.3
Irgm1
immunity-related GTPase family M member 1
chr11_-_82991829 1.172 ENSMUST00000092840.4
ENSMUST00000038211.5
Slfn9

schlafen 9

chr9_-_58249660 1.163 ENSMUST00000124063.1
ENSMUST00000126690.1
Pml

promyelocytic leukemia

chr1_+_175632169 1.161 ENSMUST00000097458.3
Kmo
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr17_-_78882508 1.061 ENSMUST00000024884.4
Eif2ak2
eukaryotic translation initiation factor 2-alpha kinase 2
chr14_+_55578360 1.046 ENSMUST00000174259.1
ENSMUST00000174563.1
ENSMUST00000089619.6
ENSMUST00000172738.1
Psme1



proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)



chr14_+_48446128 1.028 ENSMUST00000124720.1
Tmem260
transmembrane protein 260
chr6_-_125231772 1.008 ENSMUST00000043422.7
Tapbpl
TAP binding protein-like
chr1_+_66175286 1.006 ENSMUST00000114017.1
ENSMUST00000114015.1
Map2

microtubule-associated protein 2

chr6_+_71543900 0.988 ENSMUST00000065364.2
Chmp3
charged multivesicular body protein 3
chr1_+_173673651 0.982 ENSMUST00000085876.4
Pydc3
pyrin domain containing 3
chr2_-_91649751 0.960 ENSMUST00000099714.3
Zfp408
zinc finger protein 408
chr9_-_58249702 0.959 ENSMUST00000135310.1
ENSMUST00000085673.4
ENSMUST00000114136.2
ENSMUST00000153820.1
ENSMUST00000124982.1
Pml




promyelocytic leukemia




chr19_-_37178011 0.929 ENSMUST00000133988.1
Cpeb3
cytoplasmic polyadenylation element binding protein 3
chr1_+_127774164 0.917 ENSMUST00000027587.8
ENSMUST00000112570.1
Ccnt2

cyclin T2

chr3_-_151749877 0.887 ENSMUST00000029671.7
Ifi44
interferon-induced protein 44
chr19_-_4477447 0.886 ENSMUST00000059295.3
Syt12
synaptotagmin XII
chr11_+_106751226 0.862 ENSMUST00000147326.2
ENSMUST00000182896.1
ENSMUST00000182908.1
ENSMUST00000086353.4
Milr1



mast cell immunoglobulin like receptor 1



chr9_+_118040475 0.862 ENSMUST00000044454.5
Azi2
5-azacytidine induced gene 2
chr6_+_112696772 0.852 ENSMUST00000180959.1
Gm26799
predicted gene, 26799
chr18_+_60212080 0.834 ENSMUST00000031549.5
Gm4951
predicted gene 4951
chr7_+_130577334 0.822 ENSMUST00000059145.7
ENSMUST00000084513.4
Tacc2

transforming, acidic coiled-coil containing protein 2

chr4_-_42756543 0.816 ENSMUST00000102957.3
Ccl19
chemokine (C-C motif) ligand 19
chr2_+_31572775 0.779 ENSMUST00000137889.1
Fubp3
far upstream element (FUSE) binding protein 3
chr7_+_107567445 0.768 ENSMUST00000120990.1
Olfml1
olfactomedin-like 1
chr16_-_44139196 0.762 ENSMUST00000063661.6
ENSMUST00000114666.2
Atp6v1a

ATPase, H+ transporting, lysosomal V1 subunit A

chrX_+_109095359 0.712 ENSMUST00000033598.8
Sh3bgrl
SH3-binding domain glutamic acid-rich protein like
chr2_-_36136602 0.696 ENSMUST00000122456.1
Rbm18
RNA binding motif protein 18
chr5_-_120777628 0.674 ENSMUST00000044833.8
Oas3
2'-5' oligoadenylate synthetase 3
chr4_-_40239700 0.671 ENSMUST00000142055.1
Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr2_-_152332639 0.668 ENSMUST00000028964.7
Rbck1
RanBP-type and C3HC4-type zinc finger containing 1
chr9_-_58158498 0.664 ENSMUST00000168864.2
Islr
immunoglobulin superfamily containing leucine-rich repeat
chr2_-_156857946 0.654 ENSMUST00000099141.2
4930518I15Rik
RIKEN cDNA 4930518I15 gene
chr5_-_92348871 0.638 ENSMUST00000038816.6
ENSMUST00000118006.1
Cxcl10

chemokine (C-X-C motif) ligand 10

chr11_+_106751255 0.627 ENSMUST00000183111.1
ENSMUST00000106794.2
Milr1

mast cell immunoglobulin like receptor 1

chr13_-_76018524 0.618 ENSMUST00000050997.1
ENSMUST00000179078.1
ENSMUST00000167271.1
Rfesd


Rieske (Fe-S) domain containing


chr17_+_43389436 0.618 ENSMUST00000113599.1
Gpr116
G protein-coupled receptor 116
chr19_+_12460749 0.610 ENSMUST00000081035.7
Mpeg1
macrophage expressed gene 1
chrX_+_7790012 0.585 ENSMUST00000140540.1
Gripap1
GRIP1 associated protein 1
chr6_+_71543797 0.573 ENSMUST00000059462.5
Chmp3
charged multivesicular body protein 3
chr4_-_154636831 0.534 ENSMUST00000030902.6
ENSMUST00000105637.1
ENSMUST00000070313.7
ENSMUST00000105636.1
ENSMUST00000105638.2
ENSMUST00000097759.2
ENSMUST00000124771.1
Prdm16






PR domain containing 16






chr18_-_33463615 0.491 ENSMUST00000051087.8
Nrep
neuronal regeneration related protein
chr1_+_58505135 0.484 ENSMUST00000160947.1
ENSMUST00000129740.2
ENSMUST00000139825.1
Gm15834


predicted gene 15834


chr11_-_48992226 0.468 ENSMUST00000059930.2
ENSMUST00000068063.3
Gm12185
Tgtp1
predicted gene 12185
T cell specific GTPase 1
chr3_+_58526303 0.443 ENSMUST00000138848.1
Eif2a
eukaryotic translation initiation factor 2A
chr4_+_42629719 0.421 ENSMUST00000166898.2
Gm2564
predicted gene 2564
chr11_-_48871408 0.414 ENSMUST00000097271.2
Irgm1
immunity-related GTPase family M member 1
chr14_+_55604550 0.382 ENSMUST00000138037.1
Irf9
interferon regulatory factor 9
chr10_-_121586730 0.381 ENSMUST00000020316.2
Tbk1
TANK-binding kinase 1
chrX_-_38576189 0.365 ENSMUST00000115118.1
Cul4b
cullin 4B
chr3_+_81932601 0.365 ENSMUST00000029649.2
Ctso
cathepsin O
chr1_+_167618246 0.348 ENSMUST00000111380.1
Rxrg
retinoid X receptor gamma
chr1_+_37890477 0.306 ENSMUST00000027256.5
Mrpl30
mitochondrial ribosomal protein L30
chr5_-_90223923 0.306 ENSMUST00000118816.1
ENSMUST00000048363.7
Cox18

cytochrome c oxidase assembly protein 18


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
6.0 18.0 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
4.3 13.0 GO:0042560 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
2.0 5.9 GO:0046077 dUDP biosynthetic process(GO:0006227) pyrimidine nucleoside diphosphate metabolic process(GO:0009138) pyrimidine nucleoside diphosphate biosynthetic process(GO:0009139) pyrimidine deoxyribonucleoside diphosphate metabolic process(GO:0009196) pyrimidine deoxyribonucleoside diphosphate biosynthetic process(GO:0009197) dUDP metabolic process(GO:0046077)
1.9 5.7 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
1.8 5.3 GO:1900369 negative regulation of RNA interference(GO:1900369)
1.7 6.7 GO:0051562 negative regulation of mitochondrial calcium ion concentration(GO:0051562)
1.6 28.0 GO:2001275 positive regulation of glucose import in response to insulin stimulus(GO:2001275)
1.5 6.1 GO:0044565 dendritic cell proliferation(GO:0044565)
1.5 4.5 GO:0048687 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
1.4 4.3 GO:0097309 cap1 mRNA methylation(GO:0097309)
1.4 4.3 GO:0070944 neutrophil mediated killing of bacterium(GO:0070944)
1.4 4.1 GO:0035441 cell migration involved in vasculogenesis(GO:0035441) metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
1.2 5.9 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
1.1 6.8 GO:0032439 endosome localization(GO:0032439)
1.0 1.0 GO:0002578 negative regulation of antigen processing and presentation(GO:0002578) regulation of antigen processing and presentation of peptide antigen(GO:0002583) regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589)
1.0 3.0 GO:0002925 regulation of dendritic cell cytokine production(GO:0002730) positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925) detection of peptidoglycan(GO:0032499) negative regulation of interleukin-18 production(GO:0032701)
1.0 4.9 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.9 3.7 GO:0010756 positive regulation of plasminogen activation(GO:0010756)
0.9 2.7 GO:0015882 L-ascorbic acid transport(GO:0015882) transepithelial L-ascorbic acid transport(GO:0070904)
0.9 2.6 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.8 5.1 GO:0032196 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196)
0.8 6.3 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.7 12.4 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.7 4.3 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.7 4.3 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.7 1.4 GO:0045349 interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354)
0.7 2.8 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.7 7.0 GO:0010818 T cell chemotaxis(GO:0010818)
0.7 5.4 GO:0072602 interleukin-4 secretion(GO:0072602)
0.7 3.4 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.7 24.2 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.7 2.0 GO:0071918 urea transmembrane transport(GO:0071918)
0.6 16.4 GO:0034340 response to type I interferon(GO:0034340)
0.6 1.9 GO:0006533 aspartate catabolic process(GO:0006533) D-amino acid metabolic process(GO:0046416)
0.6 3.0 GO:0090168 Golgi reassembly(GO:0090168)
0.6 3.0 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
0.5 1.6 GO:0048611 ectodermal digestive tract development(GO:0007439) embryonic ectodermal digestive tract development(GO:0048611)
0.5 2.7 GO:0045627 positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.5 1.6 GO:0061763 multivesicular body-lysosome fusion(GO:0061763)
0.5 1.5 GO:1902915 negative regulation of protein import into nucleus, translocation(GO:0033159) negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.5 2.9 GO:2001012 mesenchymal cell differentiation involved in kidney development(GO:0072161) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.5 2.9 GO:0034773 histone H4-K20 trimethylation(GO:0034773) establishment of Sertoli cell barrier(GO:0097368)
0.5 4.3 GO:0042118 endothelial cell activation(GO:0042118)
0.5 1.4 GO:0046098 guanine metabolic process(GO:0046098)
0.4 1.7 GO:0035989 tendon development(GO:0035989)
0.4 6.3 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.4 4.5 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.4 2.0 GO:0006543 glutamine catabolic process(GO:0006543)
0.4 1.2 GO:0019441 tryptophan catabolic process(GO:0006569) tryptophan catabolic process to kynurenine(GO:0019441) quinolinate biosynthetic process(GO:0019805) indole-containing compound catabolic process(GO:0042436) indolalkylamine catabolic process(GO:0046218) kynurenine metabolic process(GO:0070189)
0.4 10.3 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.3 3.8 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.3 2.9 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
0.3 4.2 GO:1901898 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.3 0.9 GO:0019085 early viral transcription(GO:0019085)
0.3 2.1 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.3 2.9 GO:0090527 actin filament reorganization(GO:0090527)
0.3 3.5 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.3 18.9 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.3 1.9 GO:1990416 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.3 1.8 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.3 4.6 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.2 11.2 GO:0001919 regulation of receptor recycling(GO:0001919)
0.2 1.9 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
0.2 3.4 GO:0070932 histone H3 deacetylation(GO:0070932)
0.2 1.5 GO:0033004 negative regulation of mast cell activation(GO:0033004)
0.2 0.8 GO:1905244 regulation of modification of synaptic structure(GO:1905244)
0.2 3.1 GO:0042119 neutrophil activation(GO:0042119)
0.2 0.4 GO:0045351 type I interferon biosynthetic process(GO:0045351)
0.2 2.6 GO:0009072 aromatic amino acid family metabolic process(GO:0009072)
0.2 1.5 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.2 1.8 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.2 1.1 GO:0033689 negative regulation of osteoblast proliferation(GO:0033689)
0.2 2.4 GO:0043248 proteasome assembly(GO:0043248)
0.1 3.5 GO:0070306 lens fiber cell differentiation(GO:0070306)
0.1 1.5 GO:0070914 UV-damage excision repair(GO:0070914)
0.1 3.8 GO:0043473 pigmentation(GO:0043473)
0.1 2.7 GO:0034453 microtubule anchoring(GO:0034453)
0.1 4.5 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.1 1.3 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.1 0.5 GO:1990928 response to amino acid starvation(GO:1990928)
0.1 1.6 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.1 0.3 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.1 0.6 GO:0042126 nitrate metabolic process(GO:0042126)
0.1 0.7 GO:0060700 regulation of ribonuclease activity(GO:0060700)
0.1 4.1 GO:0042632 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.1 7.6 GO:0007286 spermatid development(GO:0007286)
0.1 0.5 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.1 3.8 GO:0006998 nuclear envelope organization(GO:0006998)
0.1 2.3 GO:0071526 semaphorin-plexin signaling pathway(GO:0071526)
0.1 2.4 GO:0046825 regulation of protein export from nucleus(GO:0046825)
0.1 0.8 GO:0030953 astral microtubule organization(GO:0030953)
0.1 1.4 GO:0060765 regulation of androgen receptor signaling pathway(GO:0060765)
0.0 0.3 GO:0051204 protein insertion into mitochondrial membrane(GO:0051204)
0.0 3.1 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 1.3 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.3 GO:0014029 neural crest formation(GO:0014029) regulation of somitogenesis(GO:0014807)
0.0 2.3 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 0.9 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 3.8 GO:0007416 synapse assembly(GO:0007416)
0.0 2.7 GO:2000045 regulation of G1/S transition of mitotic cell cycle(GO:2000045)
0.0 1.5 GO:0010508 positive regulation of autophagy(GO:0010508)
0.0 2.1 GO:0003015 heart process(GO:0003015)
0.0 0.3 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 7.2 GO:0007186 G-protein coupled receptor signaling pathway(GO:0007186)
0.0 1.3 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 1.4 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 6.7 GO:1990682 CSF1-CSF1R complex(GO:1990682)
1.0 3.8 GO:0031084 BLOC-2 complex(GO:0031084)
0.9 5.3 GO:0044530 supraspliceosomal complex(GO:0044530)
0.9 4.3 GO:0043020 NADPH oxidase complex(GO:0043020)
0.7 11.2 GO:0043083 synaptic cleft(GO:0043083)
0.7 6.3 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.7 2.7 GO:0008537 proteasome activator complex(GO:0008537)
0.6 3.9 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.5 2.1 GO:0016012 sarcoglycan complex(GO:0016012)
0.5 2.1 GO:0071797 LUBAC complex(GO:0071797)
0.5 4.5 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.5 3.5 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.5 2.8 GO:0097443 sorting endosome(GO:0097443)
0.4 2.1 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.3 1.6 GO:1990745 EARP complex(GO:1990745)
0.3 2.9 GO:0097165 nuclear stress granule(GO:0097165)
0.3 1.2 GO:1990111 spermatoproteasome complex(GO:1990111)
0.3 28.0 GO:0016363 nuclear matrix(GO:0016363)
0.2 1.5 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.2 4.5 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.2 2.8 GO:0005640 nuclear outer membrane(GO:0005640)
0.2 1.5 GO:0042629 mast cell granule(GO:0042629)
0.2 1.6 GO:0000439 core TFIIH complex(GO:0000439)
0.2 7.7 GO:0005637 nuclear inner membrane(GO:0005637)
0.2 1.6 GO:0000815 ESCRT III complex(GO:0000815)
0.2 22.6 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 3.4 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.1 1.6 GO:0044754 autolysosome(GO:0044754)
0.1 2.4 GO:0005771 multivesicular body(GO:0005771)
0.1 0.8 GO:0098837 postsynaptic recycling endosome(GO:0098837)
0.1 4.2 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 0.9 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.1 1.3 GO:0005614 interstitial matrix(GO:0005614)
0.1 3.0 GO:0008180 COP9 signalosome(GO:0008180)
0.1 1.9 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 3.4 GO:0031901 early endosome membrane(GO:0031901)
0.0 3.8 GO:0005643 nuclear pore(GO:0005643)
0.0 4.9 GO:0036064 ciliary basal body(GO:0036064)
0.0 1.9 GO:0032587 ruffle membrane(GO:0032587)
0.0 1.4 GO:0005776 autophagosome(GO:0005776)
0.0 12.5 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 1.9 GO:0010008 endosome membrane(GO:0010008)
0.0 1.9 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 10.6 GO:0009986 cell surface(GO:0009986)
0.0 20.9 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 8.9 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.5 GO:0016235 aggresome(GO:0016235)
0.0 0.7 GO:0072562 blood microparticle(GO:0072562)
0.0 0.4 GO:0042175 endoplasmic reticulum membrane(GO:0005789) nuclear outer membrane-endoplasmic reticulum membrane network(GO:0042175)
0.0 24.5 GO:0005739 mitochondrion(GO:0005739)
0.0 1.8 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 8.7 GO:0005615 extracellular space(GO:0005615)
0.0 9.7 GO:0005730 nucleolus(GO:0005730)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.3 13.0 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
2.0 5.9 GO:0004127 cytidylate kinase activity(GO:0004127) uridylate kinase activity(GO:0009041)
1.7 6.7 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
1.6 4.9 GO:0003692 left-handed Z-DNA binding(GO:0003692)
1.6 11.2 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
1.3 5.1 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
1.1 4.3 GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483)
1.1 4.3 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
1.1 4.3 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.9 4.5 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.9 2.7 GO:0070890 L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890)
0.9 2.6 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.9 2.6 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.8 4.1 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.8 3.1 GO:0019863 IgE binding(GO:0019863)
0.7 3.0 GO:0042834 peptidoglycan binding(GO:0042834)
0.7 6.3 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.6 6.4 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.6 4.5 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.5 18.9 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.5 2.3 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.4 1.3 GO:0070052 collagen V binding(GO:0070052)
0.4 5.4 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.4 2.0 GO:0004359 glutaminase activity(GO:0004359)
0.4 2.0 GO:0015265 urea channel activity(GO:0015265)
0.4 1.2 GO:0016174 NAD(P)H oxidase activity(GO:0016174) oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor(GO:0050664)
0.4 1.5 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.4 4.8 GO:0031386 protein tag(GO:0031386)
0.4 28.0 GO:0019843 rRNA binding(GO:0019843)
0.3 1.3 GO:0001069 regulatory region RNA binding(GO:0001069)
0.3 7.7 GO:0005521 lamin binding(GO:0005521)
0.3 3.4 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.3 2.7 GO:0061133 endopeptidase activator activity(GO:0061133)
0.3 2.8 GO:0043495 protein anchor(GO:0043495)
0.3 4.1 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.3 6.1 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.3 1.1 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.3 5.5 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.3 4.5 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.2 4.9 GO:0043422 protein kinase B binding(GO:0043422)
0.2 0.6 GO:0098809 nitrite reductase activity(GO:0098809)
0.2 0.8 GO:0031735 CCR10 chemokine receptor binding(GO:0031735)
0.2 7.7 GO:0070412 R-SMAD binding(GO:0070412)
0.2 1.8 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.2 2.3 GO:0017154 semaphorin receptor activity(GO:0017154)
0.2 2.1 GO:0050897 cobalt ion binding(GO:0050897)
0.2 33.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 1.9 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.2 0.6 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.2 2.6 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.1 4.2 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 0.9 GO:0097322 7SK snRNA binding(GO:0097322)
0.1 2.2 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 1.6 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.1 8.8 GO:0042826 histone deacetylase binding(GO:0042826)
0.1 2.9 GO:0017091 AU-rich element binding(GO:0017091)
0.1 4.0 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 1.6 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 6.7 GO:0008083 growth factor activity(GO:0008083)
0.1 8.4 GO:0005057 receptor signaling protein activity(GO:0005057)
0.1 1.4 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.1 12.0 GO:0001664 G-protein coupled receptor binding(GO:0001664)
0.1 5.4 GO:0030674 protein binding, bridging(GO:0030674)
0.1 2.5 GO:0016836 hydro-lyase activity(GO:0016836)
0.1 8.4 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 2.0 GO:0030332 cyclin binding(GO:0030332)
0.0 2.7 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 2.9 GO:0008013 beta-catenin binding(GO:0008013)
0.0 3.0 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 1.8 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.3 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.0 0.7 GO:0070566 adenylyltransferase activity(GO:0070566)
0.0 4.0 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 1.8 GO:0032947 protein complex scaffold(GO:0032947)
0.0 1.5 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 23.0 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 0.9 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 2.6 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.0 0.5 GO:0046332 SMAD binding(GO:0046332)
0.0 1.3 GO:0008276 protein methyltransferase activity(GO:0008276)
0.0 2.7 GO:0008017 microtubule binding(GO:0008017)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 6.7 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.4 6.7 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.3 2.6 ST_TYPE_I_INTERFERON_PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.2 4.1 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.2 3.0 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.1 5.4 PID_IL1_PATHWAY IL1-mediated signaling events
0.1 4.1 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 4.3 PID_RAC1_PATHWAY RAC1 signaling pathway
0.1 19.4 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.1 5.4 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 3.5 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 7.6 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.1 2.1 PID_MYC_PATHWAY C-MYC pathway
0.1 3.4 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 2.8 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 4.5 PID_LKB1_PATHWAY LKB1 signaling events
0.1 1.6 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 4.3 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 0.6 PID_CXCR3_PATHWAY CXCR3-mediated signaling events
0.0 1.7 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 0.5 PID_TCPTP_PATHWAY Signaling events mediated by TCPTP
0.0 0.3 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 1.1 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 0.3 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 49.9 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.6 4.7 REACTOME_PD1_SIGNALING Genes involved in PD-1 signaling
0.5 11.2 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.3 4.5 REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.3 7.8 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.3 6.4 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.2 8.4 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.2 6.7 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 1.2 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism
0.1 1.4 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.1 2.3 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.1 3.7 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.1 4.3 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 2.0 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 2.0 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.1 2.3 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.1 1.6 REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER Genes involved in Formation of incision complex in GG-NER
0.1 1.6 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 4.2 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
0.0 2.7 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 4.1 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION Genes involved in Downstream signal transduction
0.0 0.9 REACTOME_ELONGATION_ARREST_AND_RECOVERY Genes involved in Elongation arrest and recovery
0.0 0.7 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 1.3 REACTOME_TOLL_RECEPTOR_CASCADES Genes involved in Toll Receptor Cascades
0.0 2.2 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases