Motif ID: Prox1

Z-value: 0.704


Transcription factors associated with Prox1:

Gene SymbolEntrez IDGene Name
Prox1 ENSMUSG00000010175.7 Prox1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Prox1mm10_v2_chr1_-_190170671_190170744-0.401.0e-01Click!


Activity profile for motif Prox1.

activity profile for motif Prox1


Sorted Z-values histogram for motif Prox1

Sorted Z-values for motif Prox1



Network of associatons between targets according to the STRING database.



First level regulatory network of Prox1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_60144682 4.587 ENSMUST00000065383.4
E330013P04Rik
RIKEN cDNA E330013P04 gene
chr5_-_37824580 1.783 ENSMUST00000063116.9
Msx1
msh homeobox 1
chr19_-_15924560 1.391 ENSMUST00000162053.1
Psat1
phosphoserine aminotransferase 1
chr4_-_131821516 1.306 ENSMUST00000097860.2
Ptpru
protein tyrosine phosphatase, receptor type, U
chr19_+_41911851 1.073 ENSMUST00000011896.6
Pgam1
phosphoglycerate mutase 1
chr1_-_169747634 0.935 ENSMUST00000027991.5
ENSMUST00000111357.1
Rgs4

regulator of G-protein signaling 4

chr15_-_80014808 0.808 ENSMUST00000000500.6
Pdgfb
platelet derived growth factor, B polypeptide
chr18_-_20682963 0.770 ENSMUST00000165229.2
Gm10269
predicted gene 10269
chr11_-_115612878 0.763 ENSMUST00000106506.1
Mif4gd
MIF4G domain containing
chr9_+_104569671 0.759 ENSMUST00000057742.8
Cpne4
copine IV
chr6_+_58640536 0.759 ENSMUST00000145161.1
ENSMUST00000114294.1
Abcg2

ATP-binding cassette, sub-family G (WHITE), member 2

chr11_-_115612940 0.757 ENSMUST00000021087.7
Mif4gd
MIF4G domain containing
chr4_+_140701466 0.750 ENSMUST00000038893.5
ENSMUST00000138808.1
Rcc2

regulator of chromosome condensation 2

chr4_+_130913264 0.749 ENSMUST00000156225.1
ENSMUST00000156742.1
Laptm5

lysosomal-associated protein transmembrane 5

chr17_+_27839974 0.651 ENSMUST00000071006.7
Snrpc
U1 small nuclear ribonucleoprotein C
chr4_-_133967235 0.580 ENSMUST00000123234.1
Hmgn2
high mobility group nucleosomal binding domain 2
chr4_-_94556737 0.579 ENSMUST00000030313.8
Caap1
caspase activity and apoptosis inhibitor 1
chr5_+_139252343 0.574 ENSMUST00000130326.1
Get4
golgi to ER traffic protein 4 homolog (S. cerevisiae)
chr5_-_138187177 0.567 ENSMUST00000110937.1
ENSMUST00000139276.1
ENSMUST00000048698.7
ENSMUST00000123415.1
Taf6



TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor



chr4_+_130913120 0.563 ENSMUST00000151698.1
Laptm5
lysosomal-associated protein transmembrane 5
chr17_+_24426676 0.545 ENSMUST00000024946.5
Eci1
enoyl-Coenzyme A delta isomerase 1
chr6_-_131388417 0.533 ENSMUST00000032309.6
ENSMUST00000087865.2
Ybx3

Y box protein 3

chr4_-_36951223 0.523 ENSMUST00000108122.1
Lingo2
leucine rich repeat and Ig domain containing 2
chr17_-_70924958 0.476 ENSMUST00000180468.1
Gm26510
predicted gene, 26510
chr9_-_106247730 0.474 ENSMUST00000112524.2
ENSMUST00000074082.6
Alas1

aminolevulinic acid synthase 1

chr17_-_83514311 0.444 ENSMUST00000167741.1
ENSMUST00000025095.7
Cox7a2l

cytochrome c oxidase subunit VIIa polypeptide 2-like

chr14_-_96519067 0.441 ENSMUST00000022666.7
Klhl1
kelch-like 1
chr2_-_92459709 0.433 ENSMUST00000136718.1
ENSMUST00000067631.6
Slc35c1

solute carrier family 35, member C1

chr14_-_55944536 0.429 ENSMUST00000022834.6
Cma1
chymase 1, mast cell
chr8_+_31111816 0.426 ENSMUST00000046941.7
Rnf122
ring finger protein 122
chr9_+_118478182 0.408 ENSMUST00000111763.1
Eomes
eomesodermin homolog (Xenopus laevis)
chr12_+_40222758 0.406 ENSMUST00000038121.4
Gm7008
predicted gene 7008
chr2_+_27009926 0.405 ENSMUST00000114005.2
ENSMUST00000114004.1
ENSMUST00000114006.1
ENSMUST00000114007.1
Cacfd1



calcium channel flower domain containing 1



chr19_+_46056539 0.383 ENSMUST00000111899.1
ENSMUST00000099392.3
ENSMUST00000062322.4
Pprc1


peroxisome proliferative activated receptor, gamma, coactivator-related 1


chr12_-_40223149 0.382 ENSMUST00000171553.1
ENSMUST00000001672.5
Ifrd1

interferon-related developmental regulator 1

chr4_+_117835387 0.369 ENSMUST00000169885.1
Slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr7_-_126861648 0.359 ENSMUST00000129812.1
ENSMUST00000106342.1
Ino80e

INO80 complex subunit E

chr17_-_35516780 0.326 ENSMUST00000160885.1
ENSMUST00000159009.1
ENSMUST00000161012.1
Tcf19


transcription factor 19


chr8_+_85080939 0.325 ENSMUST00000140621.1
BC056474
cDNA sequence BC056474
chr11_+_72207537 0.300 ENSMUST00000021158.3
Txndc17
thioredoxin domain containing 17
chr2_+_27009936 0.296 ENSMUST00000133807.1
Cacfd1
calcium channel flower domain containing 1
chr5_+_139252314 0.295 ENSMUST00000026976.5
Get4
golgi to ER traffic protein 4 homolog (S. cerevisiae)
chr6_+_29361410 0.291 ENSMUST00000156163.1
Calu
calumenin
chr15_-_86186136 0.268 ENSMUST00000044332.9
Cerk
ceramide kinase
chr19_-_43524462 0.261 ENSMUST00000026196.7
Got1
glutamate oxaloacetate transaminase 1, soluble
chr2_+_34406882 0.257 ENSMUST00000113123.1
Mapkap1
mitogen-activated protein kinase associated protein 1
chr14_-_59440779 0.250 ENSMUST00000111253.2
ENSMUST00000095775.3
ENSMUST00000161459.1
Setdb2


SET domain, bifurcated 2


chr11_+_4986824 0.240 ENSMUST00000009234.9
ENSMUST00000109897.1
Ap1b1

adaptor protein complex AP-1, beta 1 subunit

chr7_+_28716846 0.233 ENSMUST00000108279.2
Fbxo17
F-box protein 17
chr7_+_127777095 0.220 ENSMUST00000144406.1
Setd1a
SET domain containing 1A
chr7_-_80947499 0.218 ENSMUST00000120285.1
Sec11a
SEC11 homolog A (S. cerevisiae)
chr2_+_34406845 0.214 ENSMUST00000124443.1
ENSMUST00000113124.1
Mapkap1

mitogen-activated protein kinase associated protein 1

chr4_-_68954351 0.210 ENSMUST00000030036.5
Brinp1
bone morphogenic protein/retinoic acid inducible neural specific 1
chr7_+_28716777 0.204 ENSMUST00000032818.6
ENSMUST00000108278.2
Fbxo17

F-box protein 17

chr2_+_34406949 0.203 ENSMUST00000040459.4
Mapkap1
mitogen-activated protein kinase associated protein 1
chr10_-_81496329 0.185 ENSMUST00000020463.7
Ncln
nicalin homolog (zebrafish)
chr8_-_85080679 0.173 ENSMUST00000093357.5
Wdr83
WD repeat domain containing 83
chr10_-_81496313 0.170 ENSMUST00000118498.1
Ncln
nicalin homolog (zebrafish)
chr9_-_64726583 0.159 ENSMUST00000168366.1
Rab11a
RAB11a, member RAS oncogene family
chr7_+_24081888 0.126 ENSMUST00000068975.3
Zfp180
zinc finger protein 180
chr6_+_122308684 0.116 ENSMUST00000007602.8
ENSMUST00000112610.1
M6pr

mannose-6-phosphate receptor, cation dependent

chr17_+_47630690 0.115 ENSMUST00000024779.8
Usp49
ubiquitin specific peptidase 49
chr7_-_127448993 0.101 ENSMUST00000106299.1
Zfp689
zinc finger protein 689
chr2_-_26910569 0.060 ENSMUST00000015920.5
ENSMUST00000139815.1
ENSMUST00000102899.3
Med22


mediator complex subunit 22


chr11_+_120784257 0.053 ENSMUST00000100134.3
Gps1
G protein pathway suppressor 1
chr12_-_36042476 0.046 ENSMUST00000020896.8
Tspan13
tetraspanin 13
chr4_+_133176336 0.042 ENSMUST00000105912.1
Wasf2
WAS protein family, member 2
chr2_-_136891131 0.036 ENSMUST00000144275.1
Mkks
McKusick-Kaufman syndrome
chr2_-_136891363 0.033 ENSMUST00000028730.6
ENSMUST00000110089.2
Mkks

McKusick-Kaufman syndrome

chr8_-_3467617 0.033 ENSMUST00000111081.3
ENSMUST00000118194.1
ENSMUST00000004686.6
Pex11g


peroxisomal biogenesis factor 11 gamma


chr19_+_46152505 0.011 ENSMUST00000026254.7
Gbf1
golgi-specific brefeldin A-resistance factor 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.4 1.1 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.3 1.4 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.3 0.8 GO:0003104 positive regulation of glomerular filtration(GO:0003104) negative regulation of phosphatidylinositol biosynthetic process(GO:0010512) phenotypic switching(GO:0036166) metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.3 0.8 GO:0019389 urate transport(GO:0015747) glucuronoside metabolic process(GO:0019389) negative regulation of intestinal absorption(GO:1904479)
0.2 0.5 GO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.1 0.4 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.1 0.8 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.1 0.4 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.1 0.9 GO:0036506 maintenance of unfolded protein(GO:0036506) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.1 0.7 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.1 0.3 GO:0006106 fumarate metabolic process(GO:0006106) aspartate biosynthetic process(GO:0006532) aspartate catabolic process(GO:0006533) alditol biosynthetic process(GO:0019401)
0.1 0.7 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.4 GO:0030259 lipid glycosylation(GO:0030259)
0.0 0.2 GO:0010796 regulation of multivesicular body size(GO:0010796)
0.0 0.1 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.0 0.4 GO:0002082 regulation of oxidative phosphorylation(GO:0002082)
0.0 0.6 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.0 0.2 GO:1902036 regulation of hematopoietic stem cell differentiation(GO:1902036)
0.0 1.3 GO:0034394 protein localization to cell surface(GO:0034394)
0.0 0.4 GO:0048671 negative regulation of collateral sprouting(GO:0048671)
0.0 0.1 GO:0038108 negative regulation of appetite by leptin-mediated signaling pathway(GO:0038108)
0.0 0.9 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0 0.5 GO:0006783 heme biosynthetic process(GO:0006783)
0.0 0.1 GO:0033299 secretion of lysosomal enzymes(GO:0033299)
0.0 0.2 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.3 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.0 0.2 GO:0042711 maternal behavior(GO:0042711)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.1 0.7 GO:0000243 commitment complex(GO:0000243)
0.1 0.8 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 0.7 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.6 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.2 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.2 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.4 GO:0031011 Ino80 complex(GO:0031011)
0.0 0.5 GO:0005921 gap junction(GO:0005921)
0.0 0.1 GO:1902636 kinociliary basal body(GO:1902636)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.2 0.5 GO:0016748 succinyltransferase activity(GO:0016748)
0.2 0.8 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.1 0.8 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.1 0.5 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.1 0.3 GO:0001729 ceramide kinase activity(GO:0001729)
0.1 0.3 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.1 1.4 GO:0008483 transaminase activity(GO:0008483)
0.1 0.7 GO:1990446 U1 snRNP binding(GO:1990446)
0.1 0.3 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.1 0.6 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.2 GO:1990188 euchromatin binding(GO:1990188)
0.0 0.4 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.0 0.7 GO:0070300 phosphatidic acid binding(GO:0070300)
0.0 0.3 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 0.9 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.4 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 1.8 GO:0002039 p53 binding(GO:0002039)
0.0 1.3 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.8 GO:0048365 Rac GTPase binding(GO:0048365)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 ST_TYPE_I_INTERFERON_PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 0.8 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.0 0.8 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.7 PID_PI3KCI_AKT_PATHWAY Class I PI3K signaling events mediated by Akt
0.0 0.5 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM Genes involved in Abacavir transport and metabolism
0.1 1.7 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.4 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.5 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.4 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.1 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.5 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.7 REACTOME_CD28_DEPENDENT_PI3K_AKT_SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.0 0.2 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.2 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.9 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.0 1.1 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.6 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.4 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules