Motif ID: Nr2e3

Z-value: 1.232


Transcription factors associated with Nr2e3:

Gene SymbolEntrez IDGene Name
Nr2e3 ENSMUSG00000032292.2 Nr2e3



Activity profile for motif Nr2e3.

activity profile for motif Nr2e3


Sorted Z-values histogram for motif Nr2e3

Sorted Z-values for motif Nr2e3



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr2e3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_141524379 7.952 ENSMUST00000032362.9
Slco1c1
solute carrier organic anion transporter family, member 1c1
chr18_-_35215008 7.685 ENSMUST00000091636.3
Lrrtm2
leucine rich repeat transmembrane neuronal 2
chr10_-_109764840 4.634 ENSMUST00000163071.1
Nav3
neuron navigator 3
chr2_+_65620829 4.522 ENSMUST00000028377.7
Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr6_-_13839916 4.341 ENSMUST00000060442.7
Gpr85
G protein-coupled receptor 85
chr4_-_138396438 4.331 ENSMUST00000105032.2
Fam43b
family with sequence similarity 43, member B
chr3_+_54156039 3.688 ENSMUST00000029311.6
Trpc4
transient receptor potential cation channel, subfamily C, member 4
chr1_+_19103022 3.527 ENSMUST00000037294.7
Tfap2d
transcription factor AP-2, delta
chr12_+_88953399 3.430 ENSMUST00000057634.7
Nrxn3
neurexin III
chr5_+_19227046 2.809 ENSMUST00000088516.3
Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr18_+_32938955 2.759 ENSMUST00000042868.4
Camk4
calcium/calmodulin-dependent protein kinase IV
chrX_-_143933089 2.628 ENSMUST00000087313.3
Dcx
doublecortin
chr5_-_104021919 2.596 ENSMUST00000031251.9
Hsd17b11
hydroxysteroid (17-beta) dehydrogenase 11
chr2_-_45112890 2.516 ENSMUST00000076836.6
Zeb2
zinc finger E-box binding homeobox 2
chr5_+_19907774 2.461 ENSMUST00000115267.2
Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr1_-_58424042 2.402 ENSMUST00000034868.7
Clk1
CDC-like kinase 1
chr11_-_42182924 2.380 ENSMUST00000020707.5
ENSMUST00000132971.1
Gabra1

gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1

chr16_-_22439570 2.349 ENSMUST00000170393.1
Etv5
ets variant gene 5
chr3_+_68468162 2.336 ENSMUST00000182532.1
Schip1
schwannomin interacting protein 1
chr10_-_109010955 2.334 ENSMUST00000105276.1
ENSMUST00000064054.7
Syt1

synaptotagmin I

chr14_+_101840602 2.273 ENSMUST00000159314.1
Lmo7
LIM domain only 7
chr9_+_113812547 2.264 ENSMUST00000166734.2
ENSMUST00000111838.2
ENSMUST00000163895.2
Clasp2


CLIP associating protein 2


chr4_-_151861698 2.234 ENSMUST00000049790.7
Camta1
calmodulin binding transcription activator 1
chr4_-_151861762 2.202 ENSMUST00000097774.2
Camta1
calmodulin binding transcription activator 1
chr13_-_51701041 2.189 ENSMUST00000110042.1
Gm15440
predicted gene 15440
chr4_-_151861667 2.189 ENSMUST00000169423.2
Camta1
calmodulin binding transcription activator 1
chr5_-_104021799 2.170 ENSMUST00000119025.1
Hsd17b11
hydroxysteroid (17-beta) dehydrogenase 11
chr16_-_22439719 2.126 ENSMUST00000079601.6
Etv5
ets variant gene 5
chr10_-_109009055 2.124 ENSMUST00000156979.1
Syt1
synaptotagmin I
chr8_-_54718664 2.052 ENSMUST00000144711.2
ENSMUST00000093510.2
Wdr17

WD repeat domain 17

chr11_+_111066154 1.973 ENSMUST00000042970.2
Kcnj2
potassium inwardly-rectifying channel, subfamily J, member 2
chr16_+_43510267 1.963 ENSMUST00000114695.2
Zbtb20
zinc finger and BTB domain containing 20
chr10_-_29144194 1.937 ENSMUST00000070359.2
Gm9996
predicted gene 9996
chr16_+_43508118 1.878 ENSMUST00000114690.1
Zbtb20
zinc finger and BTB domain containing 20
chr5_+_19907502 1.858 ENSMUST00000101558.3
Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chrX_-_143933204 1.822 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
Dcx


doublecortin


chr1_-_40790642 1.792 ENSMUST00000039672.5
Mfsd9
major facilitator superfamily domain containing 9
chr14_+_101840501 1.741 ENSMUST00000159026.1
Lmo7
LIM domain only 7
chr12_+_95695350 1.732 ENSMUST00000110117.1
Flrt2
fibronectin leucine rich transmembrane protein 2
chr4_+_102760294 1.681 ENSMUST00000072481.5
ENSMUST00000156596.1
ENSMUST00000080728.6
ENSMUST00000106882.2
Sgip1



SH3-domain GRB2-like (endophilin) interacting protein 1



chr17_-_24689901 1.613 ENSMUST00000007236.4
Syngr3
synaptogyrin 3
chr8_+_125995102 1.607 ENSMUST00000046765.8
Kcnk1
potassium channel, subfamily K, member 1
chr5_+_76809964 1.527 ENSMUST00000120818.1
C530008M17Rik
RIKEN cDNA C530008M17 gene
chr16_+_23107754 1.446 ENSMUST00000077605.5
ENSMUST00000115341.3
Eif4a2

eukaryotic translation initiation factor 4A2

chr18_-_22850738 1.420 ENSMUST00000092015.4
ENSMUST00000069215.6
Nol4

nucleolar protein 4

chr4_+_102760135 1.419 ENSMUST00000066824.7
Sgip1
SH3-domain GRB2-like (endophilin) interacting protein 1
chr10_+_90576570 1.400 ENSMUST00000182786.1
ENSMUST00000182600.1
Anks1b

ankyrin repeat and sterile alpha motif domain containing 1B

chr10_+_90576708 1.359 ENSMUST00000182430.1
ENSMUST00000182960.1
ENSMUST00000182045.1
ENSMUST00000182083.1
Anks1b



ankyrin repeat and sterile alpha motif domain containing 1B



chr5_-_123140135 1.325 ENSMUST00000160099.1
AI480526
expressed sequence AI480526
chr1_+_177445660 1.321 ENSMUST00000077225.6
Zbtb18
zinc finger and BTB domain containing 18
chr11_+_19924403 1.317 ENSMUST00000093298.5
Spred2
sprouty-related, EVH1 domain containing 2
chr13_-_12464925 1.316 ENSMUST00000124888.1
Lgals8
lectin, galactose binding, soluble 8
chr2_-_161109017 1.293 ENSMUST00000039782.7
ENSMUST00000134178.1
Chd6

chromodomain helicase DNA binding protein 6

chr10_+_107271827 1.277 ENSMUST00000020057.8
ENSMUST00000105280.3
Lin7a

lin-7 homolog A (C. elegans)

chr9_-_77347816 1.258 ENSMUST00000184138.1
ENSMUST00000184006.1
ENSMUST00000185144.1
ENSMUST00000034910.9
Mlip



muscular LMNA-interacting protein



chr3_-_88503187 1.248 ENSMUST00000120377.1
Lmna
lamin A
chr1_+_143640664 1.240 ENSMUST00000038252.2
B3galt2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr1_-_165934900 1.225 ENSMUST00000069609.5
ENSMUST00000111427.2
ENSMUST00000111426.4
Pou2f1


POU domain, class 2, transcription factor 1


chr3_-_144202300 1.209 ENSMUST00000121796.1
ENSMUST00000121112.1
Lmo4

LIM domain only 4

chr1_+_180111339 1.206 ENSMUST00000145181.1
Cdc42bpa
CDC42 binding protein kinase alpha
chr7_+_27731398 1.163 ENSMUST00000130997.1
Zfp60
zinc finger protein 60
chr17_-_17624458 1.152 ENSMUST00000041047.2
Lnpep
leucyl/cystinyl aminopeptidase
chr2_-_136387929 1.133 ENSMUST00000035264.2
ENSMUST00000077200.3
Pak7

p21 protein (Cdc42/Rac)-activated kinase 7

chr14_+_123659971 1.124 ENSMUST00000049681.7
Itgbl1
integrin, beta-like 1
chr10_+_90576252 1.122 ENSMUST00000182427.1
ENSMUST00000182053.1
ENSMUST00000182113.1
Anks1b


ankyrin repeat and sterile alpha motif domain containing 1B


chr2_+_96318014 1.115 ENSMUST00000135431.1
ENSMUST00000162807.2
Lrrc4c

leucine rich repeat containing 4C

chrX_+_163911401 1.082 ENSMUST00000140845.1
Ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr14_+_76504478 1.074 ENSMUST00000022587.9
ENSMUST00000134109.1
Tsc22d1

TSC22 domain family, member 1

chr3_-_88503331 1.060 ENSMUST00000029699.6
Lmna
lamin A
chr18_+_37819543 1.032 ENSMUST00000055935.5
Pcdhga9
protocadherin gamma subfamily A, 9
chr19_-_29753600 1.020 ENSMUST00000175764.1
9930021J03Rik
RIKEN cDNA 9930021J03 gene
chr5_-_34187670 0.999 ENSMUST00000042701.6
ENSMUST00000119171.1
Mxd4

Max dimerization protein 4

chr10_+_90576777 0.985 ENSMUST00000183136.1
ENSMUST00000182595.1
Anks1b

ankyrin repeat and sterile alpha motif domain containing 1B

chr10_+_127705170 0.976 ENSMUST00000079590.5
Myo1a
myosin IA
chr12_-_34528844 0.966 ENSMUST00000110819.2
Hdac9
histone deacetylase 9
chr4_+_143413002 0.961 ENSMUST00000155157.1
Pramef8
PRAME family member 8
chr10_+_62071014 0.960 ENSMUST00000053865.5
Gm5424
predicted gene 5424
chr9_-_122903102 0.959 ENSMUST00000180877.1
ENSMUST00000180486.1
A530083I20Rik

RIKEN cDNA A530083I20 gene

chr11_+_94044111 0.946 ENSMUST00000132079.1
Spag9
sperm associated antigen 9
chr5_+_98254174 0.917 ENSMUST00000031280.1
Fgf5
fibroblast growth factor 5
chr11_+_70018728 0.886 ENSMUST00000018700.6
ENSMUST00000134376.2
Dlg4

discs, large homolog 4 (Drosophila)

chr7_+_27731445 0.866 ENSMUST00000042641.7
Zfp60
zinc finger protein 60
chr16_+_31422268 0.855 ENSMUST00000089759.2
Bdh1
3-hydroxybutyrate dehydrogenase, type 1
chr4_+_143412920 0.825 ENSMUST00000132915.1
ENSMUST00000037356.7
Pramef8

PRAME family member 8

chr3_-_123690806 0.810 ENSMUST00000154668.1
Ndst3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr14_+_76504185 0.809 ENSMUST00000177207.1
Tsc22d1
TSC22 domain family, member 1
chr13_+_21478907 0.805 ENSMUST00000062609.5
Zkscan4
zinc finger with KRAB and SCAN domains 4
chr9_-_77347787 0.800 ENSMUST00000184848.1
ENSMUST00000184415.1
Mlip

muscular LMNA-interacting protein

chr10_+_90576678 0.779 ENSMUST00000182284.1
Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr11_-_76571527 0.776 ENSMUST00000072740.6
Abr
active BCR-related gene
chrX_+_166344692 0.769 ENSMUST00000112223.1
ENSMUST00000112224.1
ENSMUST00000112229.2
ENSMUST00000112228.1
ENSMUST00000112227.2
ENSMUST00000112226.2
Gpm6b





glycoprotein m6b





chr11_+_115765420 0.759 ENSMUST00000093912.4
ENSMUST00000136720.1
ENSMUST00000103034.3
ENSMUST00000141871.1
2310067B10Rik



RIKEN cDNA 2310067B10 gene



chr11_+_19924354 0.739 ENSMUST00000093299.6
Spred2
sprouty-related, EVH1 domain containing 2
chr11_-_3774706 0.738 ENSMUST00000155197.1
Osbp2
oxysterol binding protein 2
chr14_-_26442824 0.715 ENSMUST00000136635.1
ENSMUST00000125437.1
Slmap

sarcolemma associated protein

chrX_-_108834303 0.700 ENSMUST00000101283.3
ENSMUST00000150434.1
Brwd3

bromodomain and WD repeat domain containing 3

chr9_-_13245741 0.694 ENSMUST00000110582.2
Jrkl
jerky homolog-like (mouse)
chr4_+_49521176 0.678 ENSMUST00000042964.6
ENSMUST00000107696.1
Zfp189

zinc finger protein 189

chr7_+_27731373 0.664 ENSMUST00000108336.1
Zfp60
zinc finger protein 60
chr1_+_151755339 0.662 ENSMUST00000059498.5
Edem3
ER degradation enhancer, mannosidase alpha-like 3
chr11_-_68957445 0.662 ENSMUST00000108671.1
Arhgef15
Rho guanine nucleotide exchange factor (GEF) 15
chr13_-_66852017 0.610 ENSMUST00000059329.6
Gm17449
predicted gene, 17449
chr16_-_16560201 0.604 ENSMUST00000162045.1
ENSMUST00000162124.1
ENSMUST00000161861.1
Fgd4


FYVE, RhoGEF and PH domain containing 4


chr5_+_88583527 0.584 ENSMUST00000031229.6
Rufy3
RUN and FYVE domain containing 3
chr2_+_69647208 0.572 ENSMUST00000074963.2
ENSMUST00000112286.2
Bbs5

Bardet-Biedl syndrome 5 (human)

chr1_-_97977233 0.540 ENSMUST00000161567.1
Pam
peptidylglycine alpha-amidating monooxygenase
chr14_+_20674311 0.535 ENSMUST00000048657.8
Sec24c
Sec24 related gene family, member C (S. cerevisiae)
chr15_+_81872309 0.521 ENSMUST00000023116.6
Aco2
aconitase 2, mitochondrial
chr3_+_40540751 0.499 ENSMUST00000091186.3
Intu
inturned planar cell polarity effector homolog (Drosophila)
chr2_-_27027909 0.499 ENSMUST00000102890.4
ENSMUST00000153388.1
ENSMUST00000045702.5
Slc2a6


solute carrier family 2 (facilitated glucose transporter), member 6


chr10_+_119992962 0.495 ENSMUST00000154238.1
Grip1
glutamate receptor interacting protein 1
chr16_-_44016387 0.464 ENSMUST00000036174.3
Gramd1c
GRAM domain containing 1C
chr18_+_61555308 0.456 ENSMUST00000165721.1
ENSMUST00000115246.2
ENSMUST00000166990.1
ENSMUST00000163205.1
ENSMUST00000170862.1
Csnk1a1




casein kinase 1, alpha 1




chr7_+_141228766 0.445 ENSMUST00000106027.2
Phrf1
PHD and ring finger domains 1
chr7_-_87493371 0.417 ENSMUST00000004770.5
Tyr
tyrosinase
chr8_-_111910171 0.414 ENSMUST00000034430.4
Chst5
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
chr2_-_73660401 0.392 ENSMUST00000102677.4
Chn1
chimerin (chimaerin) 1
chr2_+_24949747 0.389 ENSMUST00000028350.3
Zmynd19
zinc finger, MYND domain containing 19
chr4_-_43040279 0.382 ENSMUST00000107958.1
ENSMUST00000107959.1
ENSMUST00000152846.1
Fam214b


family with sequence similarity 214, member B


chr5_-_24447587 0.374 ENSMUST00000127194.1
ENSMUST00000115033.1
ENSMUST00000123167.1
ENSMUST00000030799.8
Tmub1



transmembrane and ubiquitin-like domain containing 1



chr3_+_103279293 0.363 ENSMUST00000029444.6
ENSMUST00000106860.1
Trim33

tripartite motif-containing 33

chr8_-_60954726 0.348 ENSMUST00000110302.1
Clcn3
chloride channel 3
chr11_+_33963013 0.335 ENSMUST00000020362.2
Kcnmb1
potassium large conductance calcium-activated channel, subfamily M, beta member 1
chr11_-_65162904 0.334 ENSMUST00000093002.5
ENSMUST00000047463.8
Arhgap44

Rho GTPase activating protein 44

chr13_+_80883403 0.321 ENSMUST00000099356.2
Arrdc3
arrestin domain containing 3
chr5_+_136987019 0.313 ENSMUST00000004968.4
Plod3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr2_-_73660351 0.309 ENSMUST00000154258.1
Chn1
chimerin (chimaerin) 1
chr18_+_61555258 0.306 ENSMUST00000165123.1
Csnk1a1
casein kinase 1, alpha 1
chr7_+_83584910 0.304 ENSMUST00000039317.7
ENSMUST00000164944.1
Tmc3

transmembrane channel-like gene family 3

chr5_-_99252839 0.300 ENSMUST00000168092.1
ENSMUST00000031276.8
Rasgef1b

RasGEF domain family, member 1B

chr16_-_52454074 0.297 ENSMUST00000023312.7
Alcam
activated leukocyte cell adhesion molecule
chr3_+_76074270 0.289 ENSMUST00000038364.8
Fstl5
follistatin-like 5
chr9_-_77347889 0.277 ENSMUST00000185039.1
Mlip
muscular LMNA-interacting protein
chr3_+_118430299 0.274 ENSMUST00000180774.1
Gm26871
predicted gene, 26871
chr1_-_75317536 0.254 ENSMUST00000066668.7
Dnpep
aspartyl aminopeptidase
chr11_-_42182163 0.253 ENSMUST00000153147.1
Gabra1
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1
chr12_-_31950210 0.245 ENSMUST00000176084.1
ENSMUST00000176103.1
ENSMUST00000167458.2
Hbp1


high mobility group box transcription factor 1


chr11_-_109472611 0.236 ENSMUST00000168740.1
Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr19_-_7341433 0.226 ENSMUST00000165965.1
ENSMUST00000051711.9
ENSMUST00000169541.1
ENSMUST00000165989.1
Mark2



MAP/microtubule affinity-regulating kinase 2



chrX_+_120290259 0.218 ENSMUST00000113358.3
ENSMUST00000050239.9
ENSMUST00000113364.3
Pcdh11x


protocadherin 11 X-linked


chr17_-_71475285 0.218 ENSMUST00000127430.1
Smchd1
SMC hinge domain containing 1
chr3_-_137981523 0.216 ENSMUST00000136613.1
ENSMUST00000029806.6
Dapp1

dual adaptor for phosphotyrosine and 3-phosphoinositides 1

chr11_+_110997487 0.208 ENSMUST00000106635.1
Kcnj16
potassium inwardly-rectifying channel, subfamily J, member 16
chr12_+_69963452 0.192 ENSMUST00000110560.1
Gm3086
predicted gene 3086
chr5_+_34999111 0.189 ENSMUST00000114283.1
Rgs12
regulator of G-protein signaling 12
chr13_-_28953690 0.189 ENSMUST00000067230.5
Sox4
SRY-box containing gene 4
chr10_+_43174704 0.186 ENSMUST00000053792.1
9030612E09Rik
RIKEN cDNA 9030612E09 gene
chrX_+_42149288 0.184 ENSMUST00000115073.2
ENSMUST00000115072.1
Stag2

stromal antigen 2

chr7_-_126922887 0.183 ENSMUST00000134134.1
ENSMUST00000119781.1
ENSMUST00000121612.2
Tmem219


transmembrane protein 219


chr1_-_75316998 0.164 ENSMUST00000113605.3
Dnpep
aspartyl aminopeptidase
chr1_+_167618246 0.145 ENSMUST00000111380.1
Rxrg
retinoid X receptor gamma
chr5_+_22550391 0.132 ENSMUST00000181374.1
ENSMUST00000181764.1
ENSMUST00000181209.1
6030443J06Rik


RIKEN cDNA 6030443J06 gene


chr16_+_32271468 0.120 ENSMUST00000093183.3
Smco1
single-pass membrane protein with coiled-coil domains 1
chr12_-_31950535 0.114 ENSMUST00000172314.2
Hbp1
high mobility group box transcription factor 1
chr11_-_28584260 0.112 ENSMUST00000093253.3
ENSMUST00000109502.2
ENSMUST00000042534.8
Ccdc85a


coiled-coil domain containing 85A


chr10_-_11080956 0.107 ENSMUST00000105560.1
Grm1
glutamate receptor, metabotropic 1
chr7_+_49759100 0.078 ENSMUST00000085272.5
Htatip2
HIV-1 tat interactive protein 2, homolog (human)
chr13_+_24943144 0.069 ENSMUST00000021773.5
Gpld1
glycosylphosphatidylinositol specific phospholipase D1
chr7_+_102065485 0.068 ENSMUST00000106950.1
ENSMUST00000146450.1
Trpc2

transient receptor potential cation channel, subfamily C, member 2

chr9_-_16378231 0.067 ENSMUST00000082170.5
Fat3
FAT tumor suppressor homolog 3 (Drosophila)
chr2_-_140671440 0.065 ENSMUST00000099301.1
Flrt3
fibronectin leucine rich transmembrane protein 3
chr6_-_122340525 0.058 ENSMUST00000112600.2
Phc1
polyhomeotic-like 1 (Drosophila)
chr1_+_97770158 0.051 ENSMUST00000112844.3
ENSMUST00000112842.1
ENSMUST00000027571.6
Gin1


gypsy retrotransposon integrase 1


chr19_+_46328179 0.051 ENSMUST00000026256.2
ENSMUST00000177667.1
Fbxl15

F-box and leucine-rich repeat protein 15

chr2_+_124610278 0.048 ENSMUST00000051419.8
ENSMUST00000077847.5
ENSMUST00000078621.5
ENSMUST00000076335.5
Sema6d



sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D



chrX_+_7790012 0.041 ENSMUST00000140540.1
Gripap1
GRIP1 associated protein 1
chrX_+_7789986 0.025 ENSMUST00000136930.1
ENSMUST00000115675.2
ENSMUST00000101694.3
Gripap1


GRIP1 associated protein 1


chr4_-_129640959 0.018 ENSMUST00000132217.1
ENSMUST00000130017.1
ENSMUST00000154105.1
Txlna


taxilin alpha


chr3_-_90695706 0.003 ENSMUST00000069960.5
ENSMUST00000117167.1
S100a9

S100 calcium binding protein A9 (calgranulin B)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.8 GO:0006710 androgen catabolic process(GO:0006710)
0.9 4.5 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.9 7.1 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.7 8.0 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.6 4.8 GO:0005513 detection of calcium ion(GO:0005513)
0.5 5.6 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.5 2.3 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.4 2.5 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.3 3.1 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.3 2.3 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.3 1.3 GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)
0.3 8.6 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.3 4.5 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.3 2.6 GO:0071420 cellular response to histamine(GO:0071420)
0.3 2.0 GO:0014819 regulation of skeletal muscle contraction(GO:0014819)
0.3 1.6 GO:0060075 regulation of resting membrane potential(GO:0060075)
0.3 1.3 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.2 0.7 GO:2000297 negative regulation of synapse maturation(GO:2000297)
0.2 1.3 GO:0002317 plasma cell differentiation(GO:0002317)
0.2 3.4 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.2 0.2 GO:0003289 atrial septum primum morphogenesis(GO:0003289)
0.2 3.7 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
0.2 2.8 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.2 1.2 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.2 0.8 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313)
0.1 2.1 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.1 0.7 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.1 1.2 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.1 0.8 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.1 0.7 GO:0036508 protein deglycosylation involved in glycoprotein catabolic process(GO:0035977) protein demannosylation(GO:0036507) protein alpha-1,2-demannosylation(GO:0036508) glycoprotein ERAD pathway(GO:0097466) mannose trimming involved in glycoprotein ERAD pathway(GO:1904382)
0.1 2.3 GO:0001553 luteinization(GO:0001553)
0.1 0.9 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.1 0.3 GO:0097401 synaptic vesicle lumen acidification(GO:0097401)
0.1 0.7 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.1 0.3 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021) modification of dendritic spine(GO:0098886)
0.1 0.8 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.1 0.3 GO:0071879 positive regulation of adrenergic receptor signaling pathway(GO:0071879) negative regulation of locomotion involved in locomotory behavior(GO:0090327)
0.1 1.0 GO:0034983 peptidyl-lysine deacetylation(GO:0034983) regulation of skeletal muscle fiber development(GO:0048742)
0.1 3.8 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 1.2 GO:0021527 spinal cord association neuron differentiation(GO:0021527)
0.1 0.3 GO:0046947 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.1 6.7 GO:0050885 neuromuscular process controlling balance(GO:0050885)
0.1 0.5 GO:0006102 isocitrate metabolic process(GO:0006102)
0.1 0.2 GO:0060821 inactivation of X chromosome by DNA methylation(GO:0060821)
0.1 2.3 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.1 0.5 GO:0035428 hexose transmembrane transport(GO:0035428)
0.1 0.8 GO:1904424 regulation of GTP binding(GO:1904424)
0.1 1.2 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.0 0.5 GO:0009404 toxin metabolic process(GO:0009404)
0.0 0.5 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.0 0.3 GO:0030035 microspike assembly(GO:0030035)
0.0 0.5 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.9 GO:0023019 signal transduction involved in regulation of gene expression(GO:0023019)
0.0 0.2 GO:0038032 termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.0 1.2 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.1 GO:0010040 response to iron(II) ion(GO:0010040)
0.0 1.0 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.6 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 0.1 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.0 0.1 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.0 0.1 GO:1905244 regulation of modification of synaptic structure(GO:1905244)
0.0 0.4 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.0 1.0 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 2.4 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.0 1.3 GO:0032411 positive regulation of transporter activity(GO:0032411)
0.0 2.6 GO:0043524 negative regulation of neuron apoptotic process(GO:0043524)
0.0 0.2 GO:0010107 potassium ion import(GO:0010107)
0.0 0.2 GO:0030033 microvillus assembly(GO:0030033)
0.0 0.1 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 7.1 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.6 2.3 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.4 1.6 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.3 2.3 GO:0005638 lamin filament(GO:0005638)
0.3 4.5 GO:0031045 dense core granule(GO:0031045)
0.2 3.1 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.2 1.3 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.2 2.6 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 3.4 GO:0042734 presynaptic membrane(GO:0042734)
0.1 1.3 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 3.7 GO:0034704 calcium channel complex(GO:0034704)
0.1 4.8 GO:0005811 lipid particle(GO:0005811)
0.1 0.8 GO:0045095 keratin filament(GO:0045095)
0.1 0.6 GO:0034464 BBSome(GO:0034464)
0.1 16.3 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 2.0 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 0.5 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.3 GO:0042581 specific granule(GO:0042581)
0.0 0.2 GO:0001740 Barr body(GO:0001740)
0.0 3.2 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.2 GO:0097427 microtubule bundle(GO:0097427)
0.0 0.5 GO:0097440 apical dendrite(GO:0097440)
0.0 1.3 GO:0045171 intercellular bridge(GO:0045171)
0.0 1.0 GO:0009925 basal plasma membrane(GO:0009925)
0.0 1.1 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 1.2 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.3 GO:0042101 T cell receptor complex(GO:0042101)
0.0 2.0 GO:0016605 PML body(GO:0016605)
0.0 2.8 GO:0001650 fibrillar center(GO:0001650)
0.0 3.6 GO:0030426 growth cone(GO:0030426)
0.0 0.4 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.3 GO:0030175 filopodium(GO:0030175)
0.0 0.7 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.3 GO:0048786 presynaptic active zone(GO:0048786)
0.0 1.2 GO:0042641 actomyosin(GO:0042641)
0.0 10.5 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 4.7 GO:0005635 nuclear envelope(GO:0005635)
0.0 1.0 GO:0035097 histone methyltransferase complex(GO:0035097)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 8.0 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
1.2 7.1 GO:0070699 type II activin receptor binding(GO:0070699)
1.1 4.5 GO:0030348 syntaxin-3 binding(GO:0030348)
0.7 4.8 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.5 8.6 GO:0042043 neurexin family protein binding(GO:0042043)
0.4 2.6 GO:1904315 GABA-gated chloride ion channel activity(GO:0022851) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.3 2.1 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.3 1.2 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.3 0.9 GO:0003858 3-hydroxybutyrate dehydrogenase activity(GO:0003858)
0.3 3.4 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.2 2.0 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.2 2.8 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.2 1.3 GO:0097016 L27 domain binding(GO:0097016)
0.2 0.8 GO:0042328 heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328)
0.2 0.5 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.2 0.5 GO:0051538 3 iron, 4 sulfur cluster binding(GO:0051538)
0.2 2.3 GO:0002162 dystroglycan binding(GO:0002162)
0.1 1.6 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 0.4 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.1 6.3 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 2.2 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 3.2 GO:0042805 actinin binding(GO:0042805)
0.1 0.3 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.1 0.4 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.1 0.3 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.1 2.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 1.4 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.1 2.9 GO:0070412 R-SMAD binding(GO:0070412)
0.1 0.7 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.1 1.6 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 1.2 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0 1.6 GO:0042169 SH2 domain binding(GO:0042169)
0.0 2.4 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 1.0 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 1.7 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 4.5 GO:0005057 receptor signaling protein activity(GO:0005057)
0.0 0.5 GO:0005355 glucose transmembrane transporter activity(GO:0005355)
0.0 0.1 GO:0001639 PLC activating G-protein coupled glutamate receptor activity(GO:0001639) G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.0 0.6 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 6.6 GO:0008017 microtubule binding(GO:0008017)
0.0 1.3 GO:0001221 transcription cofactor binding(GO:0001221)
0.0 0.3 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.1 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.0 9.4 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 1.2 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 1.2 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.0 1.0 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 1.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 5.4 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0 0.2 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 0.7 GO:0032934 cholesterol binding(GO:0015485) sterol binding(GO:0032934)
0.0 0.2 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.9 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.0 1.0 GO:0003774 motor activity(GO:0003774)
0.0 0.2 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.5 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 4.5 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 4.5 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.1 2.8 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 2.1 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.2 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.9 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 1.2 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 2.3 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 0.2 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY PI3K Pathway
0.0 1.1 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.0 0.8 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.0 1.2 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.0 0.7 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 1.2 PID_CDC42_PATHWAY CDC42 signaling events
0.0 1.5 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 1.0 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 1.0 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.3 PID_MYC_PATHWAY C-MYC pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 8.0 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.4 4.5 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.4 1.2 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.3 3.7 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.2 7.1 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.2 1.6 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.2 2.6 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.1 0.9 REACTOME_SIGNALING_BY_FGFR3_MUTANTS Genes involved in Signaling by FGFR3 mutants
0.1 1.1 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 1.1 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 0.7 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 2.2 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 1.4 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 2.1 REACTOME_CA_DEPENDENT_EVENTS Genes involved in Ca-dependent events
0.0 0.5 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.8 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 2.3 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.5 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 1.2 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 2.9 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.0 0.8 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.4 REACTOME_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.0 0.4 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.1 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 1.0 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 1.1 REACTOME_G_ALPHA1213_SIGNALLING_EVENTS Genes involved in G alpha (12/13) signalling events
0.0 0.5 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import