Motif ID: Klf3

Z-value: 0.390


Transcription factors associated with Klf3:

Gene SymbolEntrez IDGene Name
Klf3 ENSMUSG00000029178.8 Klf3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf3mm10_v2_chr5_+_64812336_64812350-0.672.4e-03Click!


Activity profile for motif Klf3.

activity profile for motif Klf3


Sorted Z-values histogram for motif Klf3

Sorted Z-values for motif Klf3



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_102251852 1.217 ENSMUST00000101336.3
ENSMUST00000136277.1
Cited1

Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1

chr1_+_72824482 1.180 ENSMUST00000047328.4
Igfbp2
insulin-like growth factor binding protein 2
chr1_+_107511489 1.096 ENSMUST00000064916.2
Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr1_+_107511416 1.055 ENSMUST00000009356.4
Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chrX_-_102252154 0.963 ENSMUST00000050551.3
Cited1
Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1
chr3_+_135438722 0.721 ENSMUST00000166033.1
Ube2d3
ubiquitin-conjugating enzyme E2D 3
chr11_+_68968107 0.681 ENSMUST00000102606.3
ENSMUST00000018884.5
Slc25a35

solute carrier family 25, member 35

chr1_+_131867224 0.527 ENSMUST00000112386.1
ENSMUST00000027693.7
Rab7l1

RAB7, member RAS oncogene family-like 1

chr7_+_82337218 0.524 ENSMUST00000173828.1
Adamtsl3
ADAMTS-like 3
chr11_+_99041237 0.458 ENSMUST00000017637.6
Igfbp4
insulin-like growth factor binding protein 4
chr3_+_89266552 0.414 ENSMUST00000040824.1
Dpm3
dolichyl-phosphate mannosyltransferase polypeptide 3
chr9_+_108306205 0.337 ENSMUST00000007959.8
Rhoa
ras homolog gene family, member A
chr5_+_124541296 0.322 ENSMUST00000124529.1
Tmed2
transmembrane emp24 domain trafficking protein 2
chr9_-_108305941 0.312 ENSMUST00000044725.7
Tcta
T cell leukemia translocation altered gene
chr1_+_86064619 0.311 ENSMUST00000027432.8
Psmd1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr5_+_137630116 0.306 ENSMUST00000175968.1
Lrch4
leucine-rich repeats and calponin homology (CH) domain containing 4
chr3_+_90079540 0.264 ENSMUST00000029549.9
ENSMUST00000118566.1
ENSMUST00000119158.1
Tpm3


tropomyosin 3, gamma


chr7_-_17027807 0.220 ENSMUST00000142597.1
Ppp5c
protein phosphatase 5, catalytic subunit
chr7_-_17027853 0.215 ENSMUST00000003183.5
Ppp5c
protein phosphatase 5, catalytic subunit
chr3_+_90080442 0.143 ENSMUST00000127955.1
Tpm3
tropomyosin 3, gamma
chr19_-_53390559 0.139 ENSMUST00000025997.5
Smndc1
survival motor neuron domain containing 1
chr11_+_75679542 0.096 ENSMUST00000147718.1
Crk
v-crk sarcoma virus CT10 oncogene homolog (avian)
chr9_-_67539392 0.055 ENSMUST00000039662.8
Tln2
talin 2
chrX_-_74246534 0.025 ENSMUST00000101454.2
ENSMUST00000033699.6
Flna

filamin, alpha

chr15_+_76457438 0.006 ENSMUST00000043089.7
Scx
scleraxis

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.2 GO:0071105 response to interleukin-9(GO:0071104) response to interleukin-11(GO:0071105)
0.1 0.3 GO:0003100 angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001998) regulation of blood vessel size by renin-angiotensin(GO:0002034) renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure(GO:0003072) regulation of systemic arterial blood pressure by endothelin(GO:0003100) beta selection(GO:0043366) response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869)
0.1 1.6 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.1 0.3 GO:0072675 osteoclast fusion(GO:0072675)
0.1 0.4 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.4 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.0 0.1 GO:1990859 cellular response to endothelin(GO:1990859)
0.0 0.3 GO:0045199 maintenance of epithelial cell apical/basal polarity(GO:0045199)
0.0 0.3 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
0.0 0.7 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 2.2 GO:0010466 negative regulation of peptidase activity(GO:0010466)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.0 0.3 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.4 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.4 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.3 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540) cytosolic proteasome complex(GO:0031597)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.6 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.2 2.2 GO:0050693 LBD domain binding(GO:0050693)
0.1 0.4 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.0 2.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.3 GO:0051022 Rho GDP-dissociation inhibitor binding(GO:0051022)
0.0 0.7 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.4 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 0.7 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 2.2 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 2.7 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.5 PID_WNT_SIGNALING_PATHWAY Wnt signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.7 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.4 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.3 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.3 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.4 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction