Motif ID: Tbx4
Z-value: 1.314

Transcription factors associated with Tbx4:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Tbx4 | ENSMUSG00000000094.6 | Tbx4 |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.4 | 5.8 | GO:0030091 | protein repair(GO:0030091) |
1.4 | 4.3 | GO:0045014 | detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) detection of glucose(GO:0051594) |
1.1 | 3.3 | GO:0032474 | otolith morphogenesis(GO:0032474) |
1.1 | 5.4 | GO:0035262 | gonad morphogenesis(GO:0035262) |
1.0 | 2.9 | GO:0035934 | corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852) |
0.7 | 2.1 | GO:0051866 | general adaptation syndrome(GO:0051866) |
0.7 | 2.0 | GO:0061537 | glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537) |
0.6 | 3.2 | GO:0007386 | compartment pattern specification(GO:0007386) |
0.6 | 5.6 | GO:0071493 | cellular response to UV-B(GO:0071493) |
0.5 | 5.6 | GO:2001269 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269) |
0.4 | 3.7 | GO:0010587 | miRNA catabolic process(GO:0010587) |
0.4 | 5.4 | GO:0007213 | G-protein coupled acetylcholine receptor signaling pathway(GO:0007213) |
0.3 | 2.6 | GO:0044027 | hypermethylation of CpG island(GO:0044027) |
0.3 | 3.7 | GO:0097067 | cellular response to thyroid hormone stimulus(GO:0097067) |
0.3 | 0.8 | GO:0001951 | intestinal D-glucose absorption(GO:0001951) terminal web assembly(GO:1902896) |
0.3 | 1.1 | GO:0007412 | axon target recognition(GO:0007412) |
0.3 | 1.1 | GO:0071638 | negative regulation of monocyte chemotactic protein-1 production(GO:0071638) |
0.3 | 0.8 | GO:0070973 | protein localization to endoplasmic reticulum exit site(GO:0070973) |
0.2 | 1.0 | GO:0042905 | 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
0.2 | 2.1 | GO:0090527 | actin filament reorganization(GO:0090527) |
0.2 | 0.7 | GO:1903588 | negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588) |
0.2 | 1.6 | GO:0006297 | nucleotide-excision repair, DNA gap filling(GO:0006297) |
0.2 | 0.9 | GO:1902202 | regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202) |
0.2 | 1.2 | GO:0051189 | molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189) |
0.2 | 1.3 | GO:0048625 | myoblast fate commitment(GO:0048625) |
0.1 | 1.0 | GO:0017196 | N-terminal peptidyl-methionine acetylation(GO:0017196) |
0.1 | 1.7 | GO:0060501 | positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) |
0.1 | 1.3 | GO:0071318 | cellular response to ATP(GO:0071318) |
0.1 | 1.1 | GO:0015868 | purine ribonucleotide transport(GO:0015868) |
0.1 | 1.6 | GO:0043497 | regulation of protein heterodimerization activity(GO:0043497) |
0.1 | 8.2 | GO:0008543 | fibroblast growth factor receptor signaling pathway(GO:0008543) |
0.1 | 1.9 | GO:2000001 | regulation of DNA damage checkpoint(GO:2000001) |
0.1 | 2.9 | GO:0007129 | synapsis(GO:0007129) |
0.1 | 0.6 | GO:0032876 | negative regulation of DNA endoreduplication(GO:0032876) |
0.1 | 1.2 | GO:0007202 | activation of phospholipase C activity(GO:0007202) |
0.1 | 0.2 | GO:0015747 | urate transport(GO:0015747) |
0.1 | 0.7 | GO:1901409 | positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
0.1 | 1.0 | GO:0006465 | signal peptide processing(GO:0006465) |
0.1 | 0.7 | GO:2000741 | positive regulation of mesenchymal stem cell differentiation(GO:2000741) |
0.1 | 1.1 | GO:0050774 | negative regulation of dendrite morphogenesis(GO:0050774) |
0.1 | 1.9 | GO:0042149 | cellular response to glucose starvation(GO:0042149) |
0.0 | 1.2 | GO:0007340 | acrosome reaction(GO:0007340) |
0.0 | 8.5 | GO:0010466 | negative regulation of peptidase activity(GO:0010466) |
0.0 | 0.2 | GO:0035521 | monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522) |
0.0 | 0.3 | GO:0071294 | cellular response to zinc ion(GO:0071294) |
0.0 | 1.4 | GO:0071385 | cellular response to glucocorticoid stimulus(GO:0071385) |
0.0 | 0.6 | GO:2001256 | regulation of store-operated calcium entry(GO:2001256) |
0.0 | 0.9 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
0.0 | 0.3 | GO:0061179 | negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179) |
0.0 | 0.2 | GO:0019348 | dolichol metabolic process(GO:0019348) |
0.0 | 0.6 | GO:0030970 | retrograde protein transport, ER to cytosol(GO:0030970) |
0.0 | 1.1 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
0.0 | 0.9 | GO:0008347 | glial cell migration(GO:0008347) |
0.0 | 0.7 | GO:0006493 | protein O-linked glycosylation(GO:0006493) |
0.0 | 1.0 | GO:0030282 | bone mineralization(GO:0030282) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.9 | 5.6 | GO:0070557 | PCNA-p21 complex(GO:0070557) |
1.0 | 3.0 | GO:0097135 | cyclin E2-CDK2 complex(GO:0097135) |
0.3 | 1.9 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
0.2 | 0.8 | GO:1990357 | terminal web(GO:1990357) |
0.1 | 1.3 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) |
0.1 | 5.4 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
0.1 | 1.0 | GO:0005787 | signal peptidase complex(GO:0005787) |
0.1 | 1.0 | GO:0031415 | NatA complex(GO:0031415) |
0.1 | 0.6 | GO:0000839 | Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839) |
0.1 | 2.6 | GO:0001741 | XY body(GO:0001741) |
0.1 | 1.3 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
0.1 | 1.0 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
0.1 | 1.2 | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671) |
0.1 | 0.9 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
0.1 | 0.8 | GO:0005922 | connexon complex(GO:0005922) |
0.1 | 3.7 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
0.0 | 3.0 | GO:0005581 | collagen trimer(GO:0005581) |
0.0 | 4.5 | GO:0032993 | protein-DNA complex(GO:0032993) |
0.0 | 1.2 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
0.0 | 0.8 | GO:0035145 | exon-exon junction complex(GO:0035145) |
0.0 | 1.1 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
0.0 | 0.3 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
0.0 | 2.1 | GO:0005884 | actin filament(GO:0005884) |
0.0 | 0.7 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
0.0 | 0.2 | GO:0030061 | mitochondrial crista(GO:0030061) |
0.0 | 1.0 | GO:0001669 | acrosomal vesicle(GO:0001669) |
0.0 | 4.3 | GO:0005667 | transcription factor complex(GO:0005667) |
0.0 | 0.3 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.7 | 8.2 | GO:0005105 | type 1 fibroblast growth factor receptor binding(GO:0005105) |
2.0 | 9.9 | GO:0019828 | aspartic-type endopeptidase inhibitor activity(GO:0019828) |
1.9 | 5.6 | GO:0019912 | cyclin-dependent protein kinase activating kinase activity(GO:0019912) |
1.0 | 5.8 | GO:0033743 | peptide-methionine (R)-S-oxide reductase activity(GO:0033743) |
0.3 | 3.7 | GO:0002151 | G-quadruplex RNA binding(GO:0002151) |
0.3 | 2.6 | GO:0003886 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) |
0.3 | 0.9 | GO:0005171 | hepatocyte growth factor receptor binding(GO:0005171) |
0.3 | 1.9 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
0.3 | 2.1 | GO:0008889 | glycerophosphodiester phosphodiesterase activity(GO:0008889) |
0.2 | 2.0 | GO:0015187 | glycine transmembrane transporter activity(GO:0015187) |
0.2 | 1.0 | GO:0004028 | 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028) |
0.2 | 1.3 | GO:0046790 | virion binding(GO:0046790) |
0.1 | 5.4 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
0.1 | 1.9 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
0.1 | 1.2 | GO:0016004 | phospholipase activator activity(GO:0016004) lipase activator activity(GO:0060229) |
0.1 | 3.7 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
0.1 | 0.3 | GO:0015228 | coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122) |
0.1 | 1.2 | GO:0016783 | sulfurtransferase activity(GO:0016783) |
0.1 | 3.2 | GO:0005112 | Notch binding(GO:0005112) |
0.1 | 3.7 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
0.1 | 4.3 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
0.1 | 2.1 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
0.1 | 0.8 | GO:0005243 | gap junction channel activity(GO:0005243) |
0.1 | 1.0 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
0.1 | 1.3 | GO:0070016 | gamma-catenin binding(GO:0045295) armadillo repeat domain binding(GO:0070016) |
0.1 | 1.6 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
0.1 | 0.2 | GO:0015143 | urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702) |
0.1 | 0.6 | GO:0097027 | ubiquitin-protein transferase activator activity(GO:0097027) |
0.1 | 1.5 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
0.0 | 0.9 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
0.0 | 0.7 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
0.0 | 0.2 | GO:0003976 | UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976) |
0.0 | 0.2 | GO:0086038 | calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038) |
0.0 | 0.4 | GO:0031802 | type 5 metabotropic glutamate receptor binding(GO:0031802) |
0.0 | 0.5 | GO:1990226 | death receptor binding(GO:0005123) histone methyltransferase binding(GO:1990226) |
0.0 | 0.3 | GO:0004972 | NMDA glutamate receptor activity(GO:0004972) |
0.0 | 5.4 | GO:0001047 | core promoter binding(GO:0001047) |
0.0 | 0.6 | GO:0008307 | structural constituent of muscle(GO:0008307) |
0.0 | 1.1 | GO:0097110 | scaffold protein binding(GO:0097110) |
0.0 | 2.2 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 5.6 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
0.2 | 3.0 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
0.1 | 4.3 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
0.1 | 7.0 | PID_FGF_PATHWAY | FGF signaling pathway |
0.1 | 1.6 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
0.1 | 3.0 | PID_ERBB4_PATHWAY | ErbB4 signaling events |
0.1 | 1.8 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
0.0 | 2.6 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
0.0 | 3.2 | PID_NOTCH_PATHWAY | Notch signaling pathway |
0.0 | 1.3 | PID_IL6_7_PATHWAY | IL6-mediated signaling events |
0.0 | 0.9 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
0.0 | 1.1 | PID_RHOA_PATHWAY | RhoA signaling pathway |
0.0 | 1.2 | PID_RHOA_REG_PATHWAY | Regulation of RhoA activity |
0.0 | 1.3 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
0.0 | 0.1 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
0.0 | 0.6 | PID_PLK1_PATHWAY | PLK1 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.0 | 8.2 | REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION | Genes involved in FGFR4 ligand binding and activation |
0.3 | 4.3 | REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS | Genes involved in Regulation of gene expression in beta cells |
0.2 | 1.0 | REACTOME_ETHANOL_OXIDATION | Genes involved in Ethanol oxidation |
0.2 | 5.6 | REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
0.2 | 2.0 | REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
0.1 | 1.3 | REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR | Genes involved in Trafficking and processing of endosomal TLR |
0.1 | 1.0 | REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
0.1 | 3.0 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
0.1 | 2.9 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
0.1 | 0.8 | REACTOME_GAP_JUNCTION_ASSEMBLY | Genes involved in Gap junction assembly |
0.1 | 0.9 | REACTOME_CS_DS_DEGRADATION | Genes involved in CS/DS degradation |
0.0 | 0.9 | REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
0.0 | 1.6 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
0.0 | 5.4 | REACTOME_G_ALPHA_I_SIGNALLING_EVENTS | Genes involved in G alpha (i) signalling events |
0.0 | 0.2 | REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
0.0 | 2.1 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
0.0 | 0.8 | REACTOME_MRNA_3_END_PROCESSING | Genes involved in mRNA 3'-end processing |
0.0 | 0.7 | REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS | Genes involved in O-linked glycosylation of mucins |
0.0 | 0.3 | REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
0.0 | 0.3 | REACTOME_PEROXISOMAL_LIPID_METABOLISM | Genes involved in Peroxisomal lipid metabolism |