Motif ID: Otx1

Z-value: 0.639


Transcription factors associated with Otx1:

Gene SymbolEntrez IDGene Name
Otx1 ENSMUSG00000005917.9 Otx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Otx1mm10_v2_chr11_-_22001605_220016310.727.0e-04Click!


Activity profile for motif Otx1.

activity profile for motif Otx1


Sorted Z-values histogram for motif Otx1

Sorted Z-values for motif Otx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Otx1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_38271310 2.295 ENSMUST00000032585.6
Pop4
processing of precursor 4, ribonuclease P/MRP family, (S. cerevisiae)
chr9_+_108479849 1.900 ENSMUST00000065014.4
Lamb2
laminin, beta 2
chr5_-_98566762 1.900 ENSMUST00000086912.4
1700010H22Rik
RIKEN cDNA 1700010H22 gene
chr11_+_94936224 1.316 ENSMUST00000001547.7
Col1a1
collagen, type I, alpha 1
chr16_-_59632520 1.307 ENSMUST00000118438.1
Arl6
ADP-ribosylation factor-like 6
chrX_-_48513518 1.295 ENSMUST00000114945.2
ENSMUST00000037349.7
Aifm1

apoptosis-inducing factor, mitochondrion-associated 1

chr17_+_35861318 1.180 ENSMUST00000074259.8
ENSMUST00000174873.1
Nrm

nurim (nuclear envelope membrane protein)

chr10_-_88605017 1.174 ENSMUST00000119185.1
ENSMUST00000121629.1
Mybpc1

myosin binding protein C, slow-type

chr10_+_3973086 1.113 ENSMUST00000117291.1
ENSMUST00000120585.1
ENSMUST00000043735.7
Mthfd1l


methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like


chr2_-_151980135 1.111 ENSMUST00000062047.5
Fam110a
family with sequence similarity 110, member A
chr3_+_54481429 1.090 ENSMUST00000091130.3
Gm5641
predicted gene 5641
chr11_+_78346666 1.043 ENSMUST00000100755.3
Unc119
unc-119 homolog (C. elegans)
chr13_-_21750505 1.025 ENSMUST00000102983.1
Hist1h4k
histone cluster 1, H4k
chr5_-_5749317 0.877 ENSMUST00000015796.2
Steap1
six transmembrane epithelial antigen of the prostate 1
chr1_-_165708088 0.870 ENSMUST00000040357.8
ENSMUST00000097474.3
Rcsd1

RCSD domain containing 1

chr18_+_86711520 0.841 ENSMUST00000122464.1
Cbln2
cerebellin 2 precursor protein
chr5_-_37336870 0.824 ENSMUST00000031005.4
Evc
Ellis van Creveld gene syndrome
chr13_+_21735055 0.783 ENSMUST00000087714.4
Hist1h4j
histone cluster 1, H4j
chr13_+_41016250 0.775 ENSMUST00000021790.5
Tmem14c
transmembrane protein 14C
chr7_-_132154717 0.768 ENSMUST00000033149.4
Cpxm2
carboxypeptidase X 2 (M14 family)
chr8_-_47675556 0.739 ENSMUST00000125536.1
Ing2
inhibitor of growth family, member 2
chr13_+_21180179 0.738 ENSMUST00000021761.5
Trim27
tripartite motif-containing 27
chr4_-_41517326 0.734 ENSMUST00000030152.6
ENSMUST00000095126.4
1110017D15Rik

RIKEN cDNA 1110017D15 gene

chr1_+_131910458 0.716 ENSMUST00000062264.6
Nucks1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr4_-_123750236 0.714 ENSMUST00000102636.3
Akirin1
akirin 1
chr12_-_46818749 0.686 ENSMUST00000021438.6
Nova1
neuro-oncological ventral antigen 1
chr9_-_109082372 0.678 ENSMUST00000167504.1
Tma7
translational machinery associated 7 homolog (S. cerevisiae)
chr7_-_4063195 0.653 ENSMUST00000068865.5
ENSMUST00000086400.6
Lair1

leukocyte-associated Ig-like receptor 1

chr10_+_61648552 0.629 ENSMUST00000020286.6
Ppa1
pyrophosphatase (inorganic) 1
chr3_-_105960099 0.626 ENSMUST00000118209.1
Atp5f1
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1
chr14_-_122913751 0.606 ENSMUST00000160401.1
Ggact
gamma-glutamylamine cyclotransferase
chr2_-_60963192 0.602 ENSMUST00000028347.6
Rbms1
RNA binding motif, single stranded interacting protein 1
chr4_-_42661893 0.594 ENSMUST00000108006.3
Il11ra2
interleukin 11 receptor, alpha chain 2
chr5_+_15516489 0.578 ENSMUST00000178227.1
Gm21847
predicted gene, 21847
chr5_-_37336837 0.571 ENSMUST00000114148.1
Evc
Ellis van Creveld gene syndrome
chr17_+_35861343 0.571 ENSMUST00000172931.1
Nrm
nurim (nuclear envelope membrane protein)
chr11_+_115564434 0.544 ENSMUST00000021085.4
Nup85
nucleoporin 85
chr19_-_7039987 0.531 ENSMUST00000025918.7
Stip1
stress-induced phosphoprotein 1
chr10_-_93889758 0.513 ENSMUST00000181091.1
ENSMUST00000181217.1
ENSMUST00000047910.8
ENSMUST00000180688.1
Metap2



methionine aminopeptidase 2



chr10_+_80054029 0.497 ENSMUST00000097227.3
Gpx4
glutathione peroxidase 4
chr11_-_116274102 0.481 ENSMUST00000106425.3
Srp68
signal recognition particle 68
chr1_+_187215737 0.466 ENSMUST00000160471.1
Gpatch2
G patch domain containing 2
chr2_-_144011202 0.465 ENSMUST00000016072.5
ENSMUST00000037875.5
Rrbp1

ribosome binding protein 1

chrX_-_167209149 0.462 ENSMUST00000112176.1
Tmsb4x
thymosin, beta 4, X chromosome
chr16_-_46010212 0.450 ENSMUST00000130481.1
Plcxd2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr6_-_136828186 0.443 ENSMUST00000116514.1
Wbp11
WW domain binding protein 11
chr9_-_66975387 0.441 ENSMUST00000034929.6
Lactb
lactamase, beta
chr5_-_100373484 0.434 ENSMUST00000182433.1
Sec31a
Sec31 homolog A (S. cerevisiae)
chr1_+_187215501 0.430 ENSMUST00000097443.3
ENSMUST00000065573.7
ENSMUST00000110943.2
ENSMUST00000044812.5
Gpatch2



G patch domain containing 2



chrM_+_11734 0.426 ENSMUST00000082418.1
mt-Nd5
mitochondrially encoded NADH dehydrogenase 5
chr10_+_127642975 0.417 ENSMUST00000092074.5
ENSMUST00000120279.1
Stat6

signal transducer and activator of transcription 6

chr2_-_11603192 0.399 ENSMUST00000040314.5
Rbm17
RNA binding motif protein 17
chr19_-_6057736 0.399 ENSMUST00000007482.6
Mrpl49
mitochondrial ribosomal protein L49
chr11_+_100545607 0.399 ENSMUST00000092684.5
ENSMUST00000006976.7
Ttc25

tetratricopeptide repeat domain 25

chr11_-_116694802 0.387 ENSMUST00000079545.5
St6galnac2
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
chr2_-_26933781 0.348 ENSMUST00000154651.1
ENSMUST00000015011.3
Surf4

surfeit gene 4

chr2_+_28468056 0.343 ENSMUST00000038600.3
Mrps2
mitochondrial ribosomal protein S2
chr11_-_116274197 0.332 ENSMUST00000021133.9
Srp68
signal recognition particle 68
chr1_+_118321834 0.330 ENSMUST00000027626.6
ENSMUST00000112688.3
Mki67ip

Mki67 (FHA domain) interacting nucleolar phosphoprotein

chr19_+_5689131 0.322 ENSMUST00000004156.8
Map3k11
mitogen-activated protein kinase kinase kinase 11
chr2_+_154656959 0.318 ENSMUST00000044277.9
Chmp4b
charged multivesicular body protein 4B
chr13_+_90089705 0.313 ENSMUST00000012566.8
Tmem167
transmembrane protein 167
chr7_-_118129567 0.276 ENSMUST00000032888.7
Arl6ip1
ADP-ribosylation factor-like 6 interacting protein 1
chr11_+_3963970 0.259 ENSMUST00000020705.4
ENSMUST00000109985.1
Pes1

pescadillo homolog 1, containing BRCT domain (zebrafish)

chr15_-_74734313 0.236 ENSMUST00000023260.3
Lypd2
Ly6/Plaur domain containing 2
chr4_-_132422484 0.235 ENSMUST00000102568.3
Phactr4
phosphatase and actin regulator 4
chr17_+_8165501 0.232 ENSMUST00000097419.3
ENSMUST00000024636.8
Fgfr1op

Fgfr1 oncogene partner

chr14_-_54605908 0.231 ENSMUST00000022786.4
4931414P19Rik
RIKEN cDNA 4931414P19 gene
chr17_-_47611449 0.220 ENSMUST00000024783.8
Bysl
bystin-like
chr1_-_118311132 0.212 ENSMUST00000027623.7
Tsn
translin
chr13_-_60897439 0.186 ENSMUST00000171347.1
ENSMUST00000021884.8
Ctla2b

cytotoxic T lymphocyte-associated protein 2 beta

chr7_-_79848191 0.178 ENSMUST00000107392.1
Anpep
alanyl (membrane) aminopeptidase
chr18_+_80206887 0.171 ENSMUST00000127234.1
Gm16286
predicted gene 16286
chrM_+_10167 0.143 ENSMUST00000082414.1
mt-Nd4
mitochondrially encoded NADH dehydrogenase 4
chr14_+_29968308 0.137 ENSMUST00000112268.1
Selk
selenoprotein K
chr5_-_69590783 0.124 ENSMUST00000173927.1
Gnpda2
glucosamine-6-phosphate deaminase 2
chr19_+_4097392 0.117 ENSMUST00000174514.1
ENSMUST00000174149.1
Cdk2ap2

CDK2-associated protein 2

chr18_+_57468478 0.114 ENSMUST00000091892.2
Ctxn3
cortexin 3
chr14_+_105258673 0.109 ENSMUST00000136040.2
Ndfip2
Nedd4 family interacting protein 2
chr14_-_87141206 0.108 ENSMUST00000022599.7
Diap3
diaphanous homolog 3 (Drosophila)
chr16_-_63864114 0.083 ENSMUST00000064405.6
Epha3
Eph receptor A3
chr7_-_104950441 0.082 ENSMUST00000179862.1
Gm5900
predicted pseudogene 5900
chr13_+_21495218 0.064 ENSMUST00000104942.1
AK157302
cDNA sequence AK157302
chr13_+_93771656 0.058 ENSMUST00000091403.4
Arsb
arylsulfatase B
chr2_-_86347764 0.037 ENSMUST00000099894.2
Olfr1055
olfactory receptor 1055
chr10_+_29313164 0.035 ENSMUST00000160399.1
Echdc1
enoyl Coenzyme A hydratase domain containing 1
chr1_+_133131143 0.033 ENSMUST00000052529.3
Ppp1r15b
protein phosphatase 1, regulatory (inhibitor) subunit 15b
chr13_-_55321928 0.024 ENSMUST00000035242.7
Rab24
RAB24, member RAS oncogene family
chr14_-_87141114 0.020 ENSMUST00000168889.1
Diap3
diaphanous homolog 3 (Drosophila)
chr5_-_104456467 0.009 ENSMUST00000069263.4
Gm10047
predicted gene 10047

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.9 GO:0048682 axon extension involved in regeneration(GO:0048677) sprouting of injured axon(GO:0048682)
0.3 1.3 GO:0046909 intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445)
0.2 0.7 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
0.2 0.7 GO:0019046 release from viral latency(GO:0019046) regulation of DNA strand elongation(GO:0060382)
0.2 1.2 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.2 1.1 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.2 1.0 GO:1900186 negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of caveolin-mediated endocytosis(GO:2001286)
0.2 2.3 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.2 1.3 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.2 0.9 GO:0098706 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.1 0.7 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.1 1.3 GO:1902510 regulation of apoptotic DNA fragmentation(GO:1902510)
0.1 0.9 GO:0071474 cellular hyperosmotic response(GO:0071474)
0.1 0.4 GO:0048289 interleukin-4-mediated signaling pathway(GO:0035771) isotype switching to IgE isotypes(GO:0048289) regulation of isotype switching to IgE isotypes(GO:0048293)
0.1 1.8 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.1 0.4 GO:0097503 sialylation(GO:0097503)
0.1 0.3 GO:0007256 activation of JNKK activity(GO:0007256)
0.1 0.3 GO:0090611 ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611)
0.1 1.1 GO:0006613 cotranslational protein targeting to membrane(GO:0006613)
0.1 0.2 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.0 1.4 GO:0003416 endochondral bone growth(GO:0003416)
0.0 0.5 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.0 0.5 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0 0.2 GO:0018002 N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
0.0 0.3 GO:0007000 nucleolus organization(GO:0007000)
0.0 0.1 GO:0097155 fasciculation of sensory neuron axon(GO:0097155)
0.0 0.6 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.0 0.4 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.8 GO:0006783 heme biosynthetic process(GO:0006783)
0.0 0.3 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.6 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.5 GO:0048246 macrophage chemotaxis(GO:0048246)
0.0 0.2 GO:0035814 negative regulation of renal sodium excretion(GO:0035814)
0.0 0.9 GO:0010923 negative regulation of phosphatase activity(GO:0010923)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0005584 collagen type I trimer(GO:0005584)
0.4 2.3 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.3 1.9 GO:0043256 laminin complex(GO:0043256)
0.2 1.2 GO:0005859 muscle myosin complex(GO:0005859)
0.1 0.7 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 0.8 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.1 1.8 GO:0005652 nuclear lamina(GO:0005652)
0.1 0.7 GO:0002177 manchette(GO:0002177)
0.1 0.3 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.1 1.8 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.5 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.6 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.2 GO:0031983 vesicle lumen(GO:0031983)
0.0 0.3 GO:0000815 ESCRT III complex(GO:0000815)
0.0 1.0 GO:0051233 spindle midzone(GO:0051233)
0.0 0.3 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.3 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.2 GO:0031415 NatA complex(GO:0031415)
0.0 0.7 GO:0030904 retromer complex(GO:0030904)
0.0 1.3 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.3 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.3 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.4 1.3 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.3 0.9 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.3 1.1 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.2 1.2 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.2 0.8 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.2 0.6 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.1 0.5 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.1 0.6 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.1 1.3 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 0.3 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.1 0.2 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.2 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.0 0.5 GO:0008430 selenium binding(GO:0008430)
0.0 0.8 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.6 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.2 GO:1990190 peptide-glutamate-N-acetyltransferase activity(GO:1990190)
0.0 0.1 GO:0004342 glucosamine-6-phosphate deaminase activity(GO:0004342)
0.0 0.7 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.7 GO:0008235 metalloexopeptidase activity(GO:0008235)
0.0 0.6 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 1.9 GO:0005178 integrin binding(GO:0005178)
0.0 0.5 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.6 GO:0050699 WW domain binding(GO:0050699)
0.0 0.4 GO:0008373 sialyltransferase activity(GO:0008373)
0.0 0.0 GO:0004492 methylmalonyl-CoA decarboxylase activity(GO:0004492)
0.0 0.5 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 2.5 GO:0042393 histone binding(GO:0042393)
0.0 0.1 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.9 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 1.3 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 1.3 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.0 0.4 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 1.8 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 1.2 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.4 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.6 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.6 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 1.9 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.5 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.3 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.3 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)