Motif ID: Fli1

Z-value: 1.476


Transcription factors associated with Fli1:

Gene SymbolEntrez IDGene Name
Fli1 ENSMUSG00000016087.7 Fli1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Fli1mm10_v2_chr9_-_32541589_325416020.322.0e-01Click!


Activity profile for motif Fli1.

activity profile for motif Fli1


Sorted Z-values histogram for motif Fli1

Sorted Z-values for motif Fli1



Network of associatons between targets according to the STRING database.



First level regulatory network of Fli1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_136868537 12.919 ENSMUST00000058814.6
Rab9b
RAB9B, member RAS oncogene family
chr1_-_175491130 12.275 ENSMUST00000027812.5
Rgs7
regulator of G protein signaling 7
chr1_-_191318090 8.604 ENSMUST00000046770.9
Nenf
neuron derived neurotrophic factor
chr11_+_32000452 5.498 ENSMUST00000020537.2
ENSMUST00000109409.1
Nsg2

neuron specific gene family member 2

chr7_-_140082489 5.069 ENSMUST00000026541.7
Caly
calcyon neuron-specific vesicular protein
chr11_+_32000496 4.423 ENSMUST00000093219.3
Nsg2
neuron specific gene family member 2
chr15_+_84167804 4.234 ENSMUST00000045289.4
Pnpla3
patatin-like phospholipase domain containing 3
chr4_+_43406435 4.063 ENSMUST00000098106.2
ENSMUST00000139198.1
Rusc2

RUN and SH3 domain containing 2

chr8_+_23035116 3.492 ENSMUST00000117296.1
ENSMUST00000141784.2
Ank1

ankyrin 1, erythroid

chr17_+_79051906 3.455 ENSMUST00000040789.4
Qpct
glutaminyl-peptide cyclotransferase (glutaminyl cyclase)
chr5_+_117133567 3.290 ENSMUST00000179276.1
ENSMUST00000092889.5
ENSMUST00000145640.1
Taok3


TAO kinase 3


chr2_+_65845767 2.550 ENSMUST00000122912.1
Csrnp3
cysteine-serine-rich nuclear protein 3
chr11_+_16752203 2.453 ENSMUST00000102884.3
ENSMUST00000020329.6
Egfr

epidermal growth factor receptor

chr8_+_23035099 2.395 ENSMUST00000117662.1
Ank1
ankyrin 1, erythroid
chr6_-_77979515 2.371 ENSMUST00000159626.1
ENSMUST00000075340.5
ENSMUST00000162273.1
Ctnna2


catenin (cadherin associated protein), alpha 2


chr2_+_65845833 2.322 ENSMUST00000053910.3
Csrnp3
cysteine-serine-rich nuclear protein 3
chr11_+_57011945 2.303 ENSMUST00000094179.4
Gria1
glutamate receptor, ionotropic, AMPA1 (alpha 1)
chr13_+_118714678 2.291 ENSMUST00000022246.8
Fgf10
fibroblast growth factor 10
chr11_+_57011798 2.222 ENSMUST00000036315.9
Gria1
glutamate receptor, ionotropic, AMPA1 (alpha 1)
chr6_-_77979652 2.206 ENSMUST00000161846.1
ENSMUST00000160894.1
Ctnna2

catenin (cadherin associated protein), alpha 2

chr16_-_42340595 1.947 ENSMUST00000102817.4
Gap43
growth associated protein 43
chr13_+_109260481 1.738 ENSMUST00000153234.1
Pde4d
phosphodiesterase 4D, cAMP specific
chr2_+_4017727 1.714 ENSMUST00000177457.1
Frmd4a
FERM domain containing 4A
chr10_+_69533761 1.669 ENSMUST00000182884.1
Ank3
ankyrin 3, epithelial
chr6_-_28831747 1.619 ENSMUST00000062304.5
Lrrc4
leucine rich repeat containing 4
chr13_+_42709482 1.606 ENSMUST00000066928.5
ENSMUST00000148891.1
Phactr1

phosphatase and actin regulator 1

chr1_-_126492900 1.606 ENSMUST00000161954.1
Nckap5
NCK-associated protein 5
chr17_-_33358832 1.469 ENSMUST00000054072.8
Zfp81
zinc finger protein 81
chr10_+_69533803 1.356 ENSMUST00000182155.1
ENSMUST00000183169.1
ENSMUST00000183148.1
Ank3


ankyrin 3, epithelial


chr10_+_69534208 1.282 ENSMUST00000182439.1
ENSMUST00000092434.5
ENSMUST00000092432.5
ENSMUST00000092431.5
ENSMUST00000054167.8
ENSMUST00000047061.6
Ank3





ankyrin 3, epithelial





chrX_+_123581700 1.259 ENSMUST00000178457.1
Gm6604
predicted gene 6604
chr14_+_76487759 1.226 ENSMUST00000142683.1
Tsc22d1
TSC22 domain family, member 1
chr4_+_42655251 1.168 ENSMUST00000177785.1
Ccl27b
chemokine (C-C motif) ligand 27b
chr11_-_100759740 1.081 ENSMUST00000107361.2
Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr2_-_45113255 1.067 ENSMUST00000068415.4
ENSMUST00000127520.1
Zeb2

zinc finger E-box binding homeobox 2

chr5_-_73338580 1.045 ENSMUST00000087195.5
Ociad2
OCIA domain containing 2
chr5_-_120711927 1.027 ENSMUST00000031607.6
Dtx1
deltex 1 homolog (Drosophila)
chr2_-_45112890 1.025 ENSMUST00000076836.6
Zeb2
zinc finger E-box binding homeobox 2
chr4_+_42158092 0.997 ENSMUST00000098122.2
Gm13306
predicted gene 13306
chrX_+_123793665 0.997 ENSMUST00000178148.1
Gm5167
predicted gene 5167
chr13_+_83732438 0.990 ENSMUST00000182701.1
C130071C03Rik
RIKEN cDNA C130071C03 gene
chr2_-_45113216 0.982 ENSMUST00000124942.1
Zeb2
zinc finger E-box binding homeobox 2
chr7_+_3390629 0.958 ENSMUST00000182222.1
Cacng8
calcium channel, voltage-dependent, gamma subunit 8
chr11_-_100759942 0.901 ENSMUST00000107363.2
Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr1_+_182763961 0.892 ENSMUST00000153348.1
Susd4
sushi domain containing 4
chr9_+_50575273 0.856 ENSMUST00000059081.6
ENSMUST00000180021.1
Il18

interleukin 18

chr10_+_69534039 0.855 ENSMUST00000182557.1
Ank3
ankyrin 3, epithelial
chr15_-_76126538 0.830 ENSMUST00000054022.5
ENSMUST00000089654.3
BC024139

cDNA sequence BC024139

chr14_+_70077375 0.824 ENSMUST00000035908.1
Egr3
early growth response 3
chr17_-_24644933 0.817 ENSMUST00000019684.5
Slc9a3r2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chr6_-_120822680 0.793 ENSMUST00000019354.8
Atp6v1e1
ATPase, H+ transporting, lysosomal V1 subunit E1
chr17_+_8849974 0.788 ENSMUST00000115720.1
Pde10a
phosphodiesterase 10A
chr7_+_24862193 0.761 ENSMUST00000052897.4
ENSMUST00000170837.2
Gm9844
Gm9844
predicted pseudogene 9844
predicted pseudogene 9844
chr2_-_33086366 0.753 ENSMUST00000049618.2
Garnl3
GTPase activating RANGAP domain-like 3
chr3_-_122619442 0.712 ENSMUST00000162947.1
Fnbp1l
formin binding protein 1-like
chr7_+_110772604 0.709 ENSMUST00000005829.6
Ampd3
adenosine monophosphate deaminase 3
chr17_+_6106880 0.674 ENSMUST00000149756.1
Tulp4
tubby like protein 4
chr9_+_111439063 0.671 ENSMUST00000111879.3
Dclk3
doublecortin-like kinase 3
chr3_+_156561792 0.632 ENSMUST00000074015.4
Negr1
neuronal growth regulator 1
chr10_+_21993890 0.608 ENSMUST00000092673.4
Sgk1
serum/glucocorticoid regulated kinase 1
chrX_-_8175890 0.594 ENSMUST00000143984.1
Tbc1d25
TBC1 domain family, member 25
chr3_+_156562141 0.594 ENSMUST00000175773.1
Negr1
neuronal growth regulator 1
chr5_-_135349991 0.581 ENSMUST00000044972.7
Fkbp6
FK506 binding protein 6
chr5_+_123252087 0.580 ENSMUST00000121964.1
Wdr66
WD repeat domain 66
chr7_-_4996044 0.576 ENSMUST00000162502.1
Zfp579
zinc finger protein 579
chr5_+_134932351 0.548 ENSMUST00000047196.7
ENSMUST00000111221.2
ENSMUST00000111219.1
ENSMUST00000068617.5
ENSMUST00000111218.1
ENSMUST00000136246.1
Wbscr27





Williams Beuren syndrome chromosome region 27 (human)





chrX_+_109095359 0.547 ENSMUST00000033598.8
Sh3bgrl
SH3-binding domain glutamic acid-rich protein like
chr1_+_42952872 0.535 ENSMUST00000179766.1
Gpr45
G protein-coupled receptor 45
chr12_+_17924294 0.513 ENSMUST00000169657.1
B430203G13Rik
RIKEN cDNA B430203G13 gene
chr3_+_156561950 0.511 ENSMUST00000041425.5
ENSMUST00000106065.1
Negr1

neuronal growth regulator 1

chr11_+_96251100 0.510 ENSMUST00000129907.2
Gm53
predicted gene 53
chr11_-_95076657 0.510 ENSMUST00000001548.7
Itga3
integrin alpha 3
chrX_+_42067876 0.493 ENSMUST00000126375.1
Xiap
X-linked inhibitor of apoptosis
chr3_-_108911687 0.491 ENSMUST00000029480.8
Prpf38b
PRP38 pre-mRNA processing factor 38 (yeast) domain containing B
chr1_+_42953106 0.489 ENSMUST00000179655.1
Gpr45
G protein-coupled receptor 45
chr7_+_35186370 0.484 ENSMUST00000135452.1
ENSMUST00000001854.5
Slc7a10

solute carrier family 7 (cationic amino acid transporter, y+ system), member 10

chr10_-_127620960 0.468 ENSMUST00000121829.1
Lrp1
low density lipoprotein receptor-related protein 1
chr11_-_95076797 0.468 ENSMUST00000145671.1
ENSMUST00000120375.1
Itga3

integrin alpha 3

chr3_-_30793549 0.466 ENSMUST00000180833.1
4933429H19Rik
RIKEN cDNA 4933429H19 gene
chr6_+_145934113 0.449 ENSMUST00000032383.7
Sspn
sarcospan
chr4_+_145585166 0.442 ENSMUST00000105739.1
ENSMUST00000119718.1
Gm13212

predicted gene 13212

chr1_+_20890595 0.431 ENSMUST00000068880.7
Paqr8
progestin and adipoQ receptor family member VIII
chr12_-_118301429 0.427 ENSMUST00000026367.9
Sp4
trans-acting transcription factor 4
chr2_-_121037048 0.425 ENSMUST00000102490.3
Epb4.2
erythrocyte protein band 4.2
chr7_-_4996095 0.424 ENSMUST00000108572.1
Zfp579
zinc finger protein 579
chr10_-_127621107 0.422 ENSMUST00000049149.8
Lrp1
low density lipoprotein receptor-related protein 1
chr10_-_127620922 0.407 ENSMUST00000118455.1
Lrp1
low density lipoprotein receptor-related protein 1
chr6_+_141249161 0.407 ENSMUST00000043259.7
Pde3a
phosphodiesterase 3A, cGMP inhibited
chr7_-_4445181 0.407 ENSMUST00000138798.1
Rdh13
retinol dehydrogenase 13 (all-trans and 9-cis)
chr11_-_79296906 0.390 ENSMUST00000068448.2
Gm9964
predicted gene 9964
chr14_-_55106547 0.389 ENSMUST00000036041.8
Ap1g2
adaptor protein complex AP-1, gamma 2 subunit
chr13_+_55464237 0.381 ENSMUST00000046533.7
Prr7
proline rich 7 (synaptic)
chr10_+_24595434 0.379 ENSMUST00000020171.5
Ctgf
connective tissue growth factor
chr15_-_98763195 0.376 ENSMUST00000053183.9
Arf3
ADP-ribosylation factor 3
chr12_+_100199435 0.370 ENSMUST00000110082.3
Calm1
calmodulin 1
chrX_+_42068398 0.359 ENSMUST00000115095.2
Xiap
X-linked inhibitor of apoptosis
chr7_+_110773658 0.346 ENSMUST00000143786.1
Ampd3
adenosine monophosphate deaminase 3
chrX_+_42067836 0.333 ENSMUST00000115094.1
Xiap
X-linked inhibitor of apoptosis
chr8_-_71486037 0.327 ENSMUST00000093450.4
Ano8
anoctamin 8
chr9_-_124311750 0.327 ENSMUST00000177714.1
2010315B03Rik
RIKEN cDNA 2010315B03 gene
chrX_-_167209149 0.318 ENSMUST00000112176.1
Tmsb4x
thymosin, beta 4, X chromosome
chr2_-_38287347 0.308 ENSMUST00000102787.3
Dennd1a
DENN/MADD domain containing 1A
chr9_+_104569671 0.301 ENSMUST00000057742.8
Cpne4
copine IV
chr2_-_119547627 0.291 ENSMUST00000060009.2
Exd1
exonuclease 3'-5' domain containing 1
chr1_+_134182404 0.290 ENSMUST00000153856.1
ENSMUST00000082060.3
ENSMUST00000133701.1
ENSMUST00000132873.1
Chi3l1



chitinase 3-like 1



chr9_+_104569754 0.266 ENSMUST00000077190.6
Cpne4
copine IV
chr11_-_5915124 0.261 ENSMUST00000109823.2
ENSMUST00000109822.1
Gck

glucokinase

chr6_+_29279587 0.259 ENSMUST00000167131.1
Fam71f2
family with sequence similarity 71, member F2
chr19_-_8880883 0.255 ENSMUST00000096253.5
AI462493
expressed sequence AI462493
chr2_+_181520485 0.240 ENSMUST00000072334.5
Dnajc5
DnaJ (Hsp40) homolog, subfamily C, member 5
chr7_-_4445595 0.229 ENSMUST00000119485.1
Rdh13
retinol dehydrogenase 13 (all-trans and 9-cis)
chr19_+_8735808 0.227 ENSMUST00000049424.9
Wdr74
WD repeat domain 74
chr4_+_148602527 0.214 ENSMUST00000105701.2
ENSMUST00000052060.6
Masp2

mannan-binding lectin serine peptidase 2

chr10_+_84917616 0.212 ENSMUST00000038523.7
ENSMUST00000095385.3
Ric8b

resistance to inhibitors of cholinesterase 8 homolog B (C. elegans)

chr18_-_75697639 0.211 ENSMUST00000165559.1
Ctif
CBP80/20-dependent translation initiation factor
chr10_-_71285234 0.210 ENSMUST00000020085.6
Ube2d1
ubiquitin-conjugating enzyme E2D 1
chr2_+_121956411 0.204 ENSMUST00000110578.1
Ctdspl2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr6_+_142414012 0.180 ENSMUST00000141548.1
B230216G23Rik
RIKEN cDNA B230216G23 gene
chr10_+_19934472 0.172 ENSMUST00000095806.3
ENSMUST00000120259.1
Map3k5

mitogen-activated protein kinase kinase kinase 5

chr2_+_152962485 0.146 ENSMUST00000099197.2
ENSMUST00000103155.3
Ttll9

tubulin tyrosine ligase-like family, member 9

chr7_-_16244152 0.145 ENSMUST00000171425.1
C5ar2
complement component 5a receptor 2
chr2_+_79635444 0.144 ENSMUST00000111784.2
Ssfa2
sperm specific antigen 2
chr13_-_51203065 0.135 ENSMUST00000091708.4
Hist1h2al
histone cluster 1, H2al
chr2_+_121956651 0.125 ENSMUST00000110574.1
Ctdspl2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chrX_-_72656135 0.105 ENSMUST00000055966.6
Gabra3
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3
chr4_+_40722912 0.104 ENSMUST00000164233.1
ENSMUST00000137246.1
ENSMUST00000125442.1
Dnaja1


DnaJ (Hsp40) homolog, subfamily A, member 1


chr3_+_122245557 0.093 ENSMUST00000029769.7
Gclm
glutamate-cysteine ligase, modifier subunit
chrX_+_42150672 0.093 ENSMUST00000069619.7
Stag2
stromal antigen 2
chr9_+_70679016 0.088 ENSMUST00000144537.1
Adam10
a disintegrin and metallopeptidase domain 10
chr1_-_55226768 0.082 ENSMUST00000027121.8
ENSMUST00000114428.2
Rftn2

raftlin family member 2

chr15_-_98762992 0.081 ENSMUST00000156572.1
Arf3
ADP-ribosylation factor 3
chr10_+_81137953 0.073 ENSMUST00000117956.1
Zbtb7a
zinc finger and BTB domain containing 7a
chr5_-_116024475 0.068 ENSMUST00000111999.1
Prkab1
protein kinase, AMP-activated, beta 1 non-catalytic subunit
chr11_+_70130329 0.066 ENSMUST00000041550.5
ENSMUST00000165951.1
Mgl2

macrophage galactose N-acetyl-galactosamine specific lectin 2

chr2_+_79635416 0.057 ENSMUST00000111788.1
Ssfa2
sperm specific antigen 2
chr7_+_116093296 0.053 ENSMUST00000032899.5
1110004F10Rik
RIKEN cDNA 1110004F10 gene
chr6_-_145250177 0.053 ENSMUST00000111710.1
ENSMUST00000155145.1
ENSMUST00000032399.5
Kras


v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog


chr7_+_44428938 0.047 ENSMUST00000127790.1
Lrrc4b
leucine rich repeat containing 4B
chr16_-_18289199 0.046 ENSMUST00000009321.4
ENSMUST00000115633.1
Dgcr8

DiGeorge syndrome critical region gene 8

chr11_+_109362771 0.037 ENSMUST00000020930.7
ENSMUST00000106702.3
Gna13

guanine nucleotide binding protein, alpha 13

chr2_+_121955964 0.029 ENSMUST00000036647.6
Ctdspl2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr9_+_70678950 0.018 ENSMUST00000067880.6
Adam10
a disintegrin and metallopeptidase domain 10
chr8_+_88174560 0.010 ENSMUST00000074808.2
9430002A10Rik
RIKEN cDNA 9430002A10 gene
chr17_+_48346465 0.006 ENSMUST00000113237.3
Trem2
triggering receptor expressed on myeloid cells 2
chr6_+_4505493 0.003 ENSMUST00000031668.8
Col1a2
collagen, type I, alpha 2
chr5_-_136198908 0.000 ENSMUST00000149151.1
ENSMUST00000151786.1
Prkrip1

Prkr interacting protein 1 (IL11 inducible)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.5 GO:0018199 peptidyl-glutamine modification(GO:0018199)
0.8 8.6 GO:0032096 negative regulation of response to food(GO:0032096) negative regulation of appetite(GO:0032099)
0.8 2.3 GO:0071336 white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350) regulation of hair follicle cell proliferation(GO:0071336) positive regulation of hair follicle cell proliferation(GO:0071338)
0.5 3.1 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.5 14.3 GO:0048268 clathrin coat assembly(GO:0048268)
0.5 2.5 GO:0070459 prolactin secretion(GO:0070459)
0.5 5.2 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.4 1.2 GO:1902528 regulation of protein linear polyubiquitination(GO:1902528) positive regulation of protein linear polyubiquitination(GO:1902530)
0.4 4.6 GO:0051823 radial glia guided migration of Purkinje cell(GO:0021942) regulation of synapse structural plasticity(GO:0051823)
0.3 1.3 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
0.3 4.1 GO:0019433 triglyceride catabolic process(GO:0019433)
0.3 0.9 GO:0032817 regulation of natural killer cell proliferation(GO:0032817) positive regulation of natural killer cell proliferation(GO:0032819)
0.2 0.9 GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002924)
0.2 1.9 GO:0016198 axon choice point recognition(GO:0016198)
0.2 5.3 GO:0045838 positive regulation of membrane potential(GO:0045838)
0.2 3.3 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.2 12.9 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.2 1.1 GO:0032264 IMP salvage(GO:0032264)
0.1 0.9 GO:0034587 piRNA metabolic process(GO:0034587)
0.1 5.9 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
0.1 1.0 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.1 1.7 GO:1901898 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 0.5 GO:0015825 L-serine transport(GO:0015825)
0.1 1.6 GO:0097119 postsynaptic density protein 95 clustering(GO:0097119)
0.1 0.4 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.1 12.3 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.1 0.4 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.1 0.3 GO:0034287 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.1 0.8 GO:0033089 positive regulation of T cell differentiation in thymus(GO:0033089) regulation of gamma-delta T cell differentiation(GO:0045586) regulation of gamma-delta T cell activation(GO:0046643) positive regulation of thymocyte aggregation(GO:2000400)
0.1 0.4 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.1 0.2 GO:0009644 response to high light intensity(GO:0009644)
0.1 4.6 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 0.6 GO:1901096 regulation of autophagosome maturation(GO:1901096)
0.0 0.8 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 1.0 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0 0.6 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.0 1.7 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.1 GO:0090024 negative regulation of granulocyte chemotaxis(GO:0071623) negative regulation of neutrophil chemotaxis(GO:0090024)
0.0 0.3 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0 0.2 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.8 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.0 0.2 GO:1902916 positive regulation of protein polyubiquitination(GO:1902916)
0.0 0.1 GO:0042117 monocyte activation(GO:0042117)
0.0 1.6 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.0 0.1 GO:2000774 positive regulation of cellular senescence(GO:2000774)
0.0 0.1 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.0 0.1 GO:0032596 protein transport into membrane raft(GO:0032596) dsRNA transport(GO:0033227)
0.0 0.0 GO:0031053 primary miRNA processing(GO:0031053)
0.0 0.5 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.2 GO:1902170 cellular response to reactive nitrogen species(GO:1902170)
0.0 0.1 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.5 GO:0044308 axonal spine(GO:0044308)
0.6 12.3 GO:0044292 dendrite terminus(GO:0044292)
0.6 2.5 GO:0097487 vesicle lumen(GO:0031983) multivesicular body, internal vesicle(GO:0097487)
0.6 11.0 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.3 1.0 GO:0034667 integrin alpha3-beta1 complex(GO:0034667)
0.2 12.9 GO:0045335 phagocytic vesicle(GO:0045335)
0.1 1.9 GO:0031527 filopodium membrane(GO:0031527)
0.1 4.1 GO:0005811 lipid particle(GO:0005811)
0.0 0.8 GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain(GO:0033178)
0.0 1.7 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.4 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.2 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0 3.9 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 1.0 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 1.7 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.6 GO:0000795 synaptonemal complex(GO:0000795)
0.0 0.7 GO:0032420 stereocilium(GO:0032420)
0.0 14.8 GO:0005768 endosome(GO:0005768)
0.0 0.1 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.3 GO:0045180 basal cortex(GO:0045180)
0.0 0.0 GO:1903095 microprocessor complex(GO:0070877) ribonuclease III complex(GO:1903095)
0.0 0.5 GO:0071011 precatalytic spliceosome(GO:0071011)
0.0 0.5 GO:0097440 apical dendrite(GO:0097440)
0.0 1.2 GO:0005923 bicellular tight junction(GO:0005923)
0.0 1.6 GO:0043197 dendritic spine(GO:0043197)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 15.0 GO:0032051 clathrin light chain binding(GO:0032051)
0.9 16.8 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.9 6.2 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.8 2.5 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.7 5.9 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.6 2.3 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.4 1.3 GO:0016964 alpha-2 macroglobulin receptor activity(GO:0016964)
0.3 3.5 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.2 13.0 GO:0019003 GDP binding(GO:0019003)
0.2 1.1 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.1 0.8 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.1 2.7 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 5.2 GO:0030507 spectrin binding(GO:0030507)
0.1 0.4 GO:0031800 type 3 metabotropic glutamate receptor binding(GO:0031800)
0.1 3.1 GO:0070412 R-SMAD binding(GO:0070412)
0.1 0.6 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.1 7.2 GO:0008083 growth factor activity(GO:0008083)
0.1 0.8 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 2.1 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 1.6 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.1 GO:0004875 complement receptor activity(GO:0004875)
0.0 0.3 GO:0004340 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396)
0.0 1.2 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 0.5 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 1.0 GO:0043236 laminin binding(GO:0043236)
0.0 0.3 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.6 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 1.2 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.9 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.0 4.5 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 4.7 GO:0051015 actin filament binding(GO:0051015)
0.0 0.8 GO:0005112 Notch binding(GO:0005112)
0.0 1.0 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 2.0 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.0 0.2 GO:0001846 opsonin binding(GO:0001846)
0.0 0.2 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.0 0.3 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.0 GO:0004525 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.0 0.9 GO:0005125 cytokine activity(GO:0005125)
0.0 1.4 GO:0030674 protein binding, bridging(GO:0030674)
0.0 1.4 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 0.0 GO:0031752 D5 dopamine receptor binding(GO:0031752)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.5 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 3.5 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.1 4.6 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.1 2.3 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 0.9 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.1 1.2 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 1.2 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 0.5 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 1.1 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.0 0.8 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.4 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.0 0.6 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.0 0.9 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 0.3 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 11.0 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 2.3 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.2 4.5 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 2.5 REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING Genes involved in SHC1 events in EGFR signaling
0.1 12.3 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 1.1 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.1 2.0 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 1.5 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.0 2.1 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 1.2 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 1.0 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 4.2 REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 0.8 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 0.2 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 1.2 REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 0.5 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.9 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.2 REACTOME_PHOSPHORYLATION_OF_THE_APC_C Genes involved in Phosphorylation of the APC/C
0.0 0.2 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation