Motif ID: Stat2

Z-value: 2.760


Transcription factors associated with Stat2:

Gene SymbolEntrez IDGene Name
Stat2 ENSMUSG00000040033.9 Stat2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Stat2mm10_v2_chr10_+_128270546_1282705770.654.7e-06Click!


Activity profile for motif Stat2.

activity profile for motif Stat2


Sorted Z-values histogram for motif Stat2

Sorted Z-values for motif Stat2



Network of associatons between targets according to the STRING database.



First level regulatory network of Stat2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_173942445 34.121 ENSMUST00000042228.8
ENSMUST00000081216.5
ENSMUST00000129829.1
ENSMUST00000123708.1
ENSMUST00000111210.2
Ifi203



Mndal
interferon activated gene 203



myeloid nuclear differentiation antigen like
chr12_+_103434211 27.538 ENSMUST00000079294.5
ENSMUST00000076788.5
ENSMUST00000076702.5
ENSMUST00000066701.6
ENSMUST00000085065.5
ENSMUST00000140838.1
Ifi27





interferon, alpha-inducible protein 27





chr7_-_141010759 21.640 ENSMUST00000026565.6
Ifitm3
interferon induced transmembrane protein 3
chr3_-_107760221 18.534 ENSMUST00000153114.1
ENSMUST00000118593.1
ENSMUST00000120243.1
Csf1


colony stimulating factor 1 (macrophage)


chr16_+_23609895 17.206 ENSMUST00000038423.5
Rtp4
receptor transporter protein 4
chr6_+_121245903 17.018 ENSMUST00000032198.9
Usp18
ubiquitin specific peptidase 18
chr16_+_42907563 16.170 ENSMUST00000151244.1
ENSMUST00000114694.2
Zbtb20

zinc finger and BTB domain containing 20

chr16_+_43363855 16.138 ENSMUST00000156367.1
Zbtb20
zinc finger and BTB domain containing 20
chr1_+_153751946 15.456 ENSMUST00000183241.1
Rnasel
ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)
chr16_+_43364145 13.669 ENSMUST00000148775.1
Zbtb20
zinc finger and BTB domain containing 20
chr16_+_43235856 13.482 ENSMUST00000146708.1
Zbtb20
zinc finger and BTB domain containing 20
chr1_+_153751859 13.418 ENSMUST00000182538.1
Rnasel
ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)
chr2_+_4559742 12.757 ENSMUST00000176828.1
Frmd4a
FERM domain containing 4A
chr1_-_156674290 12.657 ENSMUST00000079625.4
Tor3a
torsin family 3, member A
chr12_-_78980758 12.548 ENSMUST00000174072.1
Tmem229b
transmembrane protein 229B
chr4_-_154636831 12.498 ENSMUST00000030902.6
ENSMUST00000105637.1
ENSMUST00000070313.7
ENSMUST00000105636.1
ENSMUST00000105638.2
ENSMUST00000097759.2
ENSMUST00000124771.1
Prdm16






PR domain containing 16






chr15_-_66812593 11.940 ENSMUST00000100572.3
Sla
src-like adaptor
chr10_+_13966268 11.849 ENSMUST00000015645.4
Hivep2
human immunodeficiency virus type I enhancer binding protein 2
chr1_+_153749496 11.533 ENSMUST00000182722.1
Rnasel
ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)
chr7_-_78578308 11.282 ENSMUST00000039431.7
Ntrk3
neurotrophic tyrosine kinase, receptor, type 3
chr1_-_170110491 11.277 ENSMUST00000027985.2
Ddr2
discoidin domain receptor family, member 2
chr8_-_84773381 11.144 ENSMUST00000109764.1
Nfix
nuclear factor I/X
chr5_+_107497762 11.120 ENSMUST00000152474.1
ENSMUST00000060553.7
A830010M20Rik

RIKEN cDNA A830010M20 gene

chr6_+_90550789 10.812 ENSMUST00000130418.1
ENSMUST00000032175.8
Aldh1l1

aldehyde dehydrogenase 1 family, member L1

chr14_+_28511344 10.784 ENSMUST00000112272.1
Wnt5a
wingless-related MMTV integration site 5A
chr6_-_39118211 10.544 ENSMUST00000038398.6
Parp12
poly (ADP-ribose) polymerase family, member 12
chr1_+_153749414 10.255 ENSMUST00000086209.3
Rnasel
ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)
chrX_+_41401128 9.857 ENSMUST00000115103.2
Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chr11_+_70459940 9.632 ENSMUST00000147289.1
ENSMUST00000126105.1
Zmynd15

zinc finger, MYND-type containing 15

chr11_+_119393060 9.544 ENSMUST00000131035.2
ENSMUST00000093902.5
Rnf213

ring finger protein 213

chr5_+_107497718 9.532 ENSMUST00000112671.2
A830010M20Rik
RIKEN cDNA A830010M20 gene
chr12_+_26469204 9.010 ENSMUST00000020969.3
Cmpk2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr17_+_86167777 8.833 ENSMUST00000097275.2
Prkce
protein kinase C, epsilon
chrX_+_41401304 8.737 ENSMUST00000076349.5
Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chr15_+_79892397 8.419 ENSMUST00000175714.1
ENSMUST00000109620.3
ENSMUST00000165537.1
Apobec3


apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3


chr18_+_69593361 8.201 ENSMUST00000114978.2
ENSMUST00000114977.1
Tcf4

transcription factor 4

chr9_+_20868628 8.072 ENSMUST00000043911.7
A230050P20Rik
RIKEN cDNA A230050P20 gene
chr15_+_79892436 8.034 ENSMUST00000175752.1
ENSMUST00000176325.1
Apobec3

apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3

chr8_-_71537402 7.824 ENSMUST00000051672.7
Bst2
bone marrow stromal cell antigen 2
chr16_-_22439719 7.558 ENSMUST00000079601.6
Etv5
ets variant gene 5
chr11_-_70459957 7.388 ENSMUST00000019064.2
Cxcl16
chemokine (C-X-C motif) ligand 16
chr4_-_156200818 7.054 ENSMUST00000085425.4
Isg15
ISG15 ubiquitin-like modifier
chr11_-_48871408 7.034 ENSMUST00000097271.2
Irgm1
immunity-related GTPase family M member 1
chr6_-_13839916 6.965 ENSMUST00000060442.7
Gpr85
G protein-coupled receptor 85
chr18_+_37400845 6.760 ENSMUST00000057228.1
Pcdhb9
protocadherin beta 9
chr11_-_48871344 6.735 ENSMUST00000049519.3
Irgm1
immunity-related GTPase family M member 1
chr4_-_40239779 6.445 ENSMUST00000037907.6
Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr16_+_26581704 6.367 ENSMUST00000096129.2
ENSMUST00000166294.2
ENSMUST00000174202.1
ENSMUST00000023156.6
Il1rap



interleukin 1 receptor accessory protein



chr12_-_79007276 6.360 ENSMUST00000056660.6
ENSMUST00000174721.1
Tmem229b

transmembrane protein 229B

chr9_-_58158498 6.187 ENSMUST00000168864.2
Islr
immunoglobulin superfamily containing leucine-rich repeat
chr11_+_72689997 6.144 ENSMUST00000155998.1
Ankfy1
ankyrin repeat and FYVE domain containing 1
chr10_+_39612934 6.069 ENSMUST00000019987.6
Traf3ip2
TRAF3 interacting protein 2
chr10_-_30655859 6.057 ENSMUST00000092610.4
Ncoa7
nuclear receptor coactivator 7
chr3_+_114030532 5.998 ENSMUST00000123619.1
ENSMUST00000092155.5
Col11a1

collagen, type XI, alpha 1

chr3_+_89730735 5.818 ENSMUST00000107405.2
ENSMUST00000029563.8
ENSMUST00000121094.1
ENSMUST00000118341.1
Adar



adenosine deaminase, RNA-specific



chr11_+_88999376 5.751 ENSMUST00000100627.2
ENSMUST00000107896.3
ENSMUST00000000284.6
Trim25


tripartite motif-containing 25


chr7_+_44836286 5.665 ENSMUST00000033015.7
Il4i1
interleukin 4 induced 1
chr3_+_94954075 5.590 ENSMUST00000107260.2
ENSMUST00000142311.1
ENSMUST00000137088.1
ENSMUST00000152869.1
ENSMUST00000107254.1
ENSMUST00000107253.1
Rfx5





regulatory factor X, 5 (influences HLA class II expression)





chr2_-_173276144 5.529 ENSMUST00000139306.1
Pmepa1
prostate transmembrane protein, androgen induced 1
chr4_+_45972233 5.236 ENSMUST00000102929.1
Tdrd7
tudor domain containing 7
chr19_-_29367294 5.222 ENSMUST00000138051.1
Plgrkt
plasminogen receptor, C-terminal lysine transmembrane protein
chrX_+_166238901 5.197 ENSMUST00000112235.1
Gpm6b
glycoprotein m6b
chr11_+_69846665 5.168 ENSMUST00000019605.2
Plscr3
phospholipid scramblase 3
chr2_-_51972990 5.130 ENSMUST00000145481.1
ENSMUST00000112705.2
Nmi

N-myc (and STAT) interactor

chr18_+_61045139 5.102 ENSMUST00000025522.4
ENSMUST00000115274.1
Pdgfrb

platelet derived growth factor receptor, beta polypeptide

chr19_+_29367447 5.001 ENSMUST00000016640.7
Cd274
CD274 antigen
chr6_+_86404336 5.000 ENSMUST00000113713.2
ENSMUST00000113708.1
Tia1

cytotoxic granule-associated RNA binding protein 1

chr13_+_42866247 4.964 ENSMUST00000131942.1
Phactr1
phosphatase and actin regulator 1
chr7_+_80860909 4.920 ENSMUST00000132163.1
ENSMUST00000147125.1
Zscan2

zinc finger and SCAN domain containing 2

chr17_+_29660710 4.876 ENSMUST00000130423.1
Cmtr1
cap methyltransferase 1
chr11_+_69846610 4.653 ENSMUST00000152566.1
ENSMUST00000108633.2
Plscr3

phospholipid scramblase 3

chr11_+_31872100 4.575 ENSMUST00000020543.6
ENSMUST00000109412.2
Cpeb4

cytoplasmic polyadenylation element binding protein 4

chr5_-_134229581 4.562 ENSMUST00000111275.1
ENSMUST00000016094.6
ENSMUST00000144086.1
Ncf1


neutrophil cytosolic factor 1


chr5_+_114896936 4.550 ENSMUST00000031542.9
ENSMUST00000146072.1
ENSMUST00000150361.1
Oasl2


2'-5' oligoadenylate synthetase-like 2


chr13_+_14063776 4.542 ENSMUST00000129488.1
ENSMUST00000110536.1
ENSMUST00000110534.1
ENSMUST00000039538.8
ENSMUST00000110533.1
Arid4b




AT rich interactive domain 4B (RBP1-like)




chr17_+_43389436 4.511 ENSMUST00000113599.1
Gpr116
G protein-coupled receptor 116
chr10_+_40629987 4.437 ENSMUST00000019977.7
Ddo
D-aspartate oxidase
chr9_+_118040576 4.426 ENSMUST00000134433.1
Azi2
5-azacytidine induced gene 2
chr11_-_118401826 4.422 ENSMUST00000106290.3
ENSMUST00000043722.3
Lgals3bp

lectin, galactoside-binding, soluble, 3 binding protein

chr2_-_45110336 4.391 ENSMUST00000028229.6
ENSMUST00000152232.1
Zeb2

zinc finger E-box binding homeobox 2

chr13_+_109260481 4.355 ENSMUST00000153234.1
Pde4d
phosphodiesterase 4D, cAMP specific
chr3_+_60501252 4.045 ENSMUST00000099087.2
Mbnl1
muscleblind-like 1 (Drosophila)
chr9_+_19641224 4.036 ENSMUST00000079042.6
Zfp317
zinc finger protein 317
chr13_+_37345338 3.962 ENSMUST00000021860.5
Ly86
lymphocyte antigen 86
chr1_+_132008285 3.936 ENSMUST00000146432.1
Elk4
ELK4, member of ETS oncogene family
chr2_-_167062981 3.884 ENSMUST00000048988.7
Znfx1
zinc finger, NFX1-type containing 1
chr16_-_44139630 3.880 ENSMUST00000137557.1
ENSMUST00000147025.1
Atp6v1a

ATPase, H+ transporting, lysosomal V1 subunit A

chr12_+_52699297 3.730 ENSMUST00000095737.3
Akap6
A kinase (PRKA) anchor protein 6
chr1_-_155972887 3.646 ENSMUST00000138762.1
ENSMUST00000124495.1
Cep350

centrosomal protein 350

chr4_-_40239700 3.646 ENSMUST00000142055.1
Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr9_+_118040509 3.645 ENSMUST00000133580.1
Azi2
5-azacytidine induced gene 2
chr11_+_29463735 3.644 ENSMUST00000155854.1
Ccdc88a
coiled coil domain containing 88A
chr2_-_167062607 3.643 ENSMUST00000128676.1
Znfx1
zinc finger, NFX1-type containing 1
chrX_-_95444789 3.640 ENSMUST00000084535.5
Amer1
APC membrane recruitment 1
chr17_+_29660595 3.605 ENSMUST00000024816.6
Cmtr1
cap methyltransferase 1
chr18_+_37725706 3.544 ENSMUST00000066149.6
Pcdhga9
protocadherin gamma subfamily A, 9
chr16_+_24393350 3.516 ENSMUST00000038053.6
Lpp
LIM domain containing preferred translocation partner in lipoma
chr6_+_127446819 3.509 ENSMUST00000112191.1
Parp11
poly (ADP-ribose) polymerase family, member 11
chr7_+_78578830 3.492 ENSMUST00000064591.4
Gm9885
predicted gene 9885
chr3_+_81932601 3.437 ENSMUST00000029649.2
Ctso
cathepsin O
chrX_-_139998519 3.312 ENSMUST00000113007.1
ENSMUST00000033810.7
ENSMUST00000113011.2
ENSMUST00000087400.5
Rbm41



RNA binding motif protein 41



chr7_-_141266415 3.301 ENSMUST00000106023.1
ENSMUST00000097952.2
ENSMUST00000026571.4
Irf7


interferon regulatory factor 7


chr11_-_47379405 3.274 ENSMUST00000077221.5
Sgcd
sarcoglycan, delta (dystrophin-associated glycoprotein)
chr8_+_46739745 3.154 ENSMUST00000034041.7
Irf2
interferon regulatory factor 2
chr9_-_58249660 3.145 ENSMUST00000124063.1
ENSMUST00000126690.1
Pml

promyelocytic leukemia

chr8_-_105938384 3.105 ENSMUST00000034369.8
Psmb10
proteasome (prosome, macropain) subunit, beta type 10
chr5_-_73256555 3.020 ENSMUST00000101127.5
ENSMUST00000171179.1
Fryl
Fryl
furry homolog-like (Drosophila)
furry homolog-like (Drosophila)
chr4_+_138972885 3.003 ENSMUST00000123636.1
ENSMUST00000043042.3
ENSMUST00000050949.2
Tmco4


transmembrane and coiled-coil domains 4


chr8_+_88651341 2.997 ENSMUST00000109634.2
Nod2
nucleotide-binding oligomerization domain containing 2
chr14_+_55578123 2.982 ENSMUST00000174484.1
Psme1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr10_+_52358767 2.921 ENSMUST00000180473.1
Gm26741
predicted gene, 26741
chr17_-_78882508 2.787 ENSMUST00000024884.4
Eif2ak2
eukaryotic translation initiation factor 2-alpha kinase 2
chr10_+_128270546 2.709 ENSMUST00000105238.3
ENSMUST00000085708.2
Stat2

signal transducer and activator of transcription 2

chr2_-_156857946 2.655 ENSMUST00000099141.2
4930518I15Rik
RIKEN cDNA 4930518I15 gene
chr1_-_9748376 2.593 ENSMUST00000057438.6
Vcpip1
valosin containing protein (p97)/p47 complex interacting protein 1
chr15_-_76243401 2.592 ENSMUST00000165738.1
ENSMUST00000075689.6
Parp10

poly (ADP-ribose) polymerase family, member 10

chr9_-_78443204 2.582 ENSMUST00000070742.7
ENSMUST00000034898.7
Mb21d1

Mab-21 domain containing 1

chr9_+_118040475 2.570 ENSMUST00000044454.5
Azi2
5-azacytidine induced gene 2
chrX_+_109095359 2.483 ENSMUST00000033598.8
Sh3bgrl
SH3-binding domain glutamic acid-rich protein like
chr19_+_55741810 2.479 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr16_+_35938470 2.435 ENSMUST00000114878.1
Parp9
poly (ADP-ribose) polymerase family, member 9
chr1_+_171018920 2.423 ENSMUST00000078825.4
Fcgr4
Fc receptor, IgG, low affinity IV
chr2_-_62646146 2.318 ENSMUST00000112459.3
ENSMUST00000028259.5
Ifih1

interferon induced with helicase C domain 1

chr7_+_30121915 2.310 ENSMUST00000098596.3
ENSMUST00000153792.1
Zfp382

zinc finger protein 382

chr2_+_155382186 2.290 ENSMUST00000134218.1
Trp53inp2
transformation related protein 53 inducible nuclear protein 2
chr16_+_35938972 2.252 ENSMUST00000023622.6
ENSMUST00000114877.1
Parp9

poly (ADP-ribose) polymerase family, member 9

chr14_+_55578360 2.243 ENSMUST00000174259.1
ENSMUST00000174563.1
ENSMUST00000089619.6
ENSMUST00000172738.1
Psme1



proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)



chr13_+_49504774 2.235 ENSMUST00000051504.7
Ecm2
extracellular matrix protein 2, female organ and adipocyte specific
chr7_-_46795661 2.222 ENSMUST00000123725.1
Hps5
Hermansky-Pudlak syndrome 5 homolog (human)
chr12_+_90738201 2.163 ENSMUST00000181874.1
Gm26512
predicted gene, 26512
chr3_+_137671524 2.134 ENSMUST00000166899.2
Gm21962
predicted gene, 21962
chr3_-_151749877 2.133 ENSMUST00000029671.7
Ifi44
interferon-induced protein 44
chr9_+_96259246 2.125 ENSMUST00000179065.1
ENSMUST00000165768.2
Tfdp2

transcription factor Dp 2

chr9_-_58249702 2.062 ENSMUST00000135310.1
ENSMUST00000085673.4
ENSMUST00000114136.2
ENSMUST00000153820.1
ENSMUST00000124982.1
Pml




promyelocytic leukemia




chr11_-_49051122 2.029 ENSMUST00000132768.1
ENSMUST00000101295.2
ENSMUST00000093152.1
9930111J21Rik2


RIKEN cDNA 9930111J21 gene 2


chr9_+_32116040 1.954 ENSMUST00000174641.1
Arhgap32
Rho GTPase activating protein 32
chr17_+_33955812 1.929 ENSMUST00000025178.9
ENSMUST00000114330.2
Vps52

vacuolar protein sorting 52 (yeast)

chr8_-_122551316 1.825 ENSMUST00000067252.7
Piezo1
piezo-type mechanosensitive ion channel component 1
chr1_-_105356658 1.821 ENSMUST00000058688.5
ENSMUST00000172299.1
Rnf152

ring finger protein 152

chr18_+_60212080 1.814 ENSMUST00000031549.5
Gm4951
predicted gene 4951
chr1_+_58505135 1.808 ENSMUST00000160947.1
ENSMUST00000129740.2
ENSMUST00000139825.1
Gm15834


predicted gene 15834


chr14_+_48446128 1.800 ENSMUST00000124720.1
Tmem260
transmembrane protein 260
chr1_+_85650008 1.798 ENSMUST00000054279.8
ENSMUST00000147552.1
ENSMUST00000153574.1
ENSMUST00000150967.1
Sp100



nuclear antigen Sp100



chr16_-_44139003 1.789 ENSMUST00000124102.1
Atp6v1a
ATPase, H+ transporting, lysosomal V1 subunit A
chr7_-_46795881 1.776 ENSMUST00000107653.1
ENSMUST00000107654.1
ENSMUST00000014562.7
ENSMUST00000152759.1
Hps5



Hermansky-Pudlak syndrome 5 homolog (human)



chr19_-_4477447 1.775 ENSMUST00000059295.3
Syt12
synaptotagmin XII
chr4_-_58911902 1.759 ENSMUST00000134848.1
ENSMUST00000107557.2
ENSMUST00000149301.1
AI314180


expressed sequence AI314180


chr9_+_118478182 1.748 ENSMUST00000111763.1
Eomes
eomesodermin homolog (Xenopus laevis)
chr19_-_21472552 1.703 ENSMUST00000087600.3
Gda
guanine deaminase
chr11_+_106751226 1.660 ENSMUST00000147326.2
ENSMUST00000182896.1
ENSMUST00000182908.1
ENSMUST00000086353.4
Milr1



mast cell immunoglobulin like receptor 1



chr16_+_8470763 1.628 ENSMUST00000046470.9
ENSMUST00000150790.1
ENSMUST00000142899.1
Mettl22


methyltransferase like 22


chrX_-_38576166 1.623 ENSMUST00000050083.5
Cul4b
cullin 4B
chr9_-_117252450 1.618 ENSMUST00000111773.3
ENSMUST00000068962.7
ENSMUST00000044901.7
Rbms3


RNA binding motif, single stranded interacting protein


chr17_+_33919332 1.604 ENSMUST00000025161.7
Tapbp
TAP binding protein
chr19_-_6084873 1.590 ENSMUST00000160977.1
ENSMUST00000159859.1
Zfpl1

zinc finger like protein 1

chr18_-_39490649 1.579 ENSMUST00000115567.1
Nr3c1
nuclear receptor subfamily 3, group C, member 1
chr1_-_52190901 1.550 ENSMUST00000156887.1
ENSMUST00000129107.1
Gls

glutaminase

chr4_+_108834601 1.532 ENSMUST00000030296.8
Txndc12
thioredoxin domain containing 12 (endoplasmic reticulum)
chr2_-_91649785 1.417 ENSMUST00000111333.1
Zfp408
zinc finger protein 408
chr7_+_130577334 1.417 ENSMUST00000059145.7
ENSMUST00000084513.4
Tacc2

transforming, acidic coiled-coil containing protein 2

chr16_-_44139196 1.393 ENSMUST00000063661.6
ENSMUST00000114666.2
Atp6v1a

ATPase, H+ transporting, lysosomal V1 subunit A

chr1_+_175632169 1.385 ENSMUST00000097458.3
Kmo
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr1_+_52119438 1.360 ENSMUST00000070968.7
Stat1
signal transducer and activator of transcription 1
chr1_+_66175272 1.348 ENSMUST00000156636.2
Map2
microtubule-associated protein 2
chr19_+_7297658 1.305 ENSMUST00000170286.1
Gm17227
predicted gene 17227
chr11_-_121229095 1.278 ENSMUST00000137299.1
ENSMUST00000169393.1
BC017643

cDNA sequence BC017643

chr2_+_91650116 1.242 ENSMUST00000111331.2
Arhgap1
Rho GTPase activating protein 1
chr6_+_112696772 1.214 ENSMUST00000180959.1
Gm26799
predicted gene, 26799
chr2_-_91649751 1.175 ENSMUST00000099714.3
Zfp408
zinc finger protein 408
chr2_+_91650169 1.173 ENSMUST00000090614.4
Arhgap1
Rho GTPase activating protein 1
chr11_+_106751255 1.153 ENSMUST00000183111.1
ENSMUST00000106794.2
Milr1

mast cell immunoglobulin like receptor 1

chr4_-_46536096 1.117 ENSMUST00000102924.2
Trim14
tripartite motif-containing 14
chr7_+_107567445 1.105 ENSMUST00000120990.1
Olfml1
olfactomedin-like 1
chr6_+_71543900 1.071 ENSMUST00000065364.2
Chmp3
charged multivesicular body protein 3
chr14_-_63543931 1.064 ENSMUST00000058679.5
Mtmr9
myotubularin related protein 9
chr11_+_58199556 1.024 ENSMUST00000058704.8
ENSMUST00000035266.4
ENSMUST00000094169.4
ENSMUST00000168280.1
Irgm2
Igtp


immunity-related GTPase family M member 2
interferon gamma induced GTPase


chr18_-_39489776 1.023 ENSMUST00000025300.6
Nr3c1
nuclear receptor subfamily 3, group C, member 1
chr17_+_34187545 1.017 ENSMUST00000170086.1
Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr14_-_79481268 0.965 ENSMUST00000022601.5
Wbp4
WW domain binding protein 4
chr18_+_38296635 0.959 ENSMUST00000072376.5
ENSMUST00000170811.1
Rnf14

ring finger protein 14

chr1_+_167618246 0.944 ENSMUST00000111380.1
Rxrg
retinoid X receptor gamma
chr11_+_43474276 0.919 ENSMUST00000173002.1
ENSMUST00000057679.3
C1qtnf2

C1q and tumor necrosis factor related protein 2

chr3_+_142560052 0.919 ENSMUST00000106222.2
Gbp3
guanylate binding protein 3
chr13_-_23710714 0.894 ENSMUST00000091707.6
ENSMUST00000006787.7
ENSMUST00000091706.6
Hfe


hemochromatosis


chr2_-_132111440 0.892 ENSMUST00000128899.1
Slc23a2
solute carrier family 23 (nucleobase transporters), member 2
chr3_+_142560108 0.878 ENSMUST00000128609.1
ENSMUST00000029935.7
Gbp3

guanylate binding protein 3

chr11_-_82991829 0.877 ENSMUST00000092840.4
ENSMUST00000038211.5
Slfn9

schlafen 9

chr6_+_71543797 0.848 ENSMUST00000059462.5
Chmp3
charged multivesicular body protein 3
chrX_-_38576189 0.809 ENSMUST00000115118.1
Cul4b
cullin 4B
chr7_+_46796088 0.731 ENSMUST00000006774.4
ENSMUST00000165031.1
Gtf2h1

general transcription factor II H, polypeptide 1

chr3_+_58525821 0.709 ENSMUST00000029387.8
Eif2a
eukaryotic translation initiation factor 2A
chr3_+_66981352 0.694 ENSMUST00000162036.1
Rsrc1
arginine/serine-rich coiled-coil 1
chr10_+_116301374 0.694 ENSMUST00000092167.5
Ptprb
protein tyrosine phosphatase, receptor type, B
chr17_+_34187789 0.655 ENSMUST00000041633.8
Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr1_+_143640664 0.643 ENSMUST00000038252.2
B3galt2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr5_-_137116177 0.641 ENSMUST00000054384.5
ENSMUST00000152207.1
Trim56

tripartite motif-containing 56

chr1_-_184732616 0.638 ENSMUST00000048572.6
Hlx
H2.0-like homeobox
chr3_+_19957037 0.634 ENSMUST00000091309.5
ENSMUST00000108329.1
ENSMUST00000003714.6
Cp


ceruloplasmin


chr3_+_142560351 0.634 ENSMUST00000106221.1
Gbp3
guanylate binding protein 3
chr1_-_165708088 0.633 ENSMUST00000040357.8
ENSMUST00000097474.3
Rcsd1

RCSD domain containing 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
6.1 18.3 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
5.7 17.2 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
3.8 11.3 GO:0048687 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
3.7 14.8 GO:0060332 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
3.6 10.8 GO:0042560 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
3.6 10.8 GO:0061349 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) hypophysis morphogenesis(GO:0048850) cervix development(GO:0060067) planar cell polarity pathway involved in outflow tract morphogenesis(GO:0061347) planar cell polarity pathway involved in ventricular septum morphogenesis(GO:0061348) planar cell polarity pathway involved in cardiac right atrium morphogenesis(GO:0061349) planar cell polarity pathway involved in cardiac muscle tissue morphogenesis(GO:0061350) planar cell polarity pathway involved in pericardium morphogenesis(GO:0061354)
3.0 9.0 GO:0046077 dUDP biosynthetic process(GO:0006227) pyrimidine nucleoside diphosphate metabolic process(GO:0009138) pyrimidine nucleoside diphosphate biosynthetic process(GO:0009139) pyrimidine deoxyribonucleoside diphosphate metabolic process(GO:0009196) pyrimidine deoxyribonucleoside diphosphate biosynthetic process(GO:0009197) dUDP metabolic process(GO:0046077)
3.0 50.7 GO:2001275 positive regulation of glucose import in response to insulin stimulus(GO:2001275)
2.8 8.5 GO:0097309 cap1 mRNA methylation(GO:0097309)
2.8 11.2 GO:0044565 dendritic cell proliferation(GO:0044565)
2.7 16.5 GO:0032196 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196)
2.6 5.1 GO:0045349 interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354)
2.5 10.1 GO:0009597 detection of virus(GO:0009597)
2.2 8.8 GO:0051562 negative regulation of mitochondrial calcium ion concentration(GO:0051562)
2.1 17.0 GO:0080184 response to stilbenoid(GO:0035634) response to phenylpropanoid(GO:0080184)
2.0 7.8 GO:1901252 regulation of intracellular transport of viral material(GO:1901252)
1.9 5.8 GO:1900369 negative regulation of RNA interference(GO:1900369)
1.7 5.2 GO:0050713 negative regulation of interleukin-1 beta secretion(GO:0050713)
1.7 65.1 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
1.7 5.1 GO:0035441 cell migration involved in vasculogenesis(GO:0035441) metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
1.6 40.4 GO:0034340 response to type I interferon(GO:0034340)
1.6 12.5 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
1.5 4.6 GO:0070944 neutrophil mediated killing of bacterium(GO:0070944)
1.5 7.6 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
1.5 3.0 GO:0002730 regulation of dendritic cell cytokine production(GO:0002730)
1.5 4.4 GO:0006533 aspartate catabolic process(GO:0006533) D-amino acid metabolic process(GO:0046416)
1.4 8.6 GO:0032439 endosome localization(GO:0032439)
1.4 11.3 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
1.3 36.6 GO:0035458 cellular response to interferon-beta(GO:0035458)
1.3 5.2 GO:0010756 positive regulation of plasminogen activation(GO:0010756)
1.1 5.5 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
1.1 8.7 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
1.1 9.5 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
1.0 6.0 GO:0035989 tendon development(GO:0035989)
0.9 3.7 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.9 1.8 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.9 3.6 GO:2001012 mesenchymal cell differentiation involved in kidney development(GO:0072161) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.9 2.6 GO:1902915 negative regulation of protein import into nucleus, translocation(GO:0033159) negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.8 6.4 GO:0072602 interleukin-4 secretion(GO:0072602)
0.8 4.5 GO:0034773 histone H4-K20 trimethylation(GO:0034773) establishment of Sertoli cell barrier(GO:0097368)
0.7 5.2 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.7 7.4 GO:0010818 T cell chemotaxis(GO:0010818)
0.7 8.1 GO:0042118 endothelial cell activation(GO:0042118)
0.7 4.4 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.7 3.6 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.7 2.8 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
0.7 3.4 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
0.6 1.9 GO:0048611 ectodermal digestive tract development(GO:0007439) embryonic ectodermal digestive tract development(GO:0048611)
0.6 1.9 GO:0061763 multivesicular body-lysosome fusion(GO:0061763)
0.6 3.1 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.6 11.1 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.6 4.9 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.6 30.0 GO:0046825 regulation of protein export from nucleus(GO:0046825)
0.6 1.1 GO:0002589 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589)
0.6 1.7 GO:0046098 guanine metabolic process(GO:0046098)
0.6 5.0 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
0.5 4.4 GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844)
0.5 2.6 GO:0090168 Golgi reassembly(GO:0090168)
0.5 6.1 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.5 4.0 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
0.5 1.4 GO:0019441 tryptophan catabolic process(GO:0006569) tryptophan catabolic process to kynurenine(GO:0019441) quinolinate biosynthetic process(GO:0019805) indole-containing compound catabolic process(GO:0042436) indolalkylamine catabolic process(GO:0046218) kynurenine metabolic process(GO:0070189)
0.4 1.7 GO:0046967 cytosol to ER transport(GO:0046967)
0.4 18.6 GO:0001919 regulation of receptor recycling(GO:0001919)
0.4 5.7 GO:0009072 aromatic amino acid family metabolic process(GO:0009072)
0.4 2.8 GO:1900225 NLRP3 inflammasome complex assembly(GO:0044546) regulation of NLRP3 inflammasome complex assembly(GO:1900225)
0.4 6.3 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.4 7.1 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.3 3.0 GO:0090527 actin filament reorganization(GO:0090527)
0.3 1.6 GO:0006543 glutamine catabolic process(GO:0006543)
0.3 0.9 GO:0015882 L-ascorbic acid transport(GO:0015882) transepithelial L-ascorbic acid transport(GO:0070904)
0.3 3.9 GO:0070932 histone H3 deacetylation(GO:0070932)
0.3 6.6 GO:0019884 antigen processing and presentation of exogenous antigen(GO:0019884)
0.3 2.8 GO:0033004 negative regulation of mast cell activation(GO:0033004)
0.2 1.3 GO:1990928 response to amino acid starvation(GO:1990928)
0.2 0.4 GO:0045351 type I interferon biosynthetic process(GO:0045351)
0.2 0.6 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.2 0.6 GO:0048014 Tie signaling pathway(GO:0048014)
0.2 2.4 GO:0070914 UV-damage excision repair(GO:0070914)
0.2 5.2 GO:0070306 lens fiber cell differentiation(GO:0070306)
0.2 11.9 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.2 2.4 GO:0042119 neutrophil activation(GO:0042119)
0.2 0.5 GO:0019085 early viral transcription(GO:0019085)
0.2 9.8 GO:0042632 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.2 0.6 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.2 3.6 GO:0034453 microtubule anchoring(GO:0034453)
0.1 1.8 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.1 1.8 GO:0043248 proteasome assembly(GO:0043248)
0.1 1.0 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.1 4.0 GO:0006376 mRNA splice site selection(GO:0006376)
0.1 1.4 GO:0030953 astral microtubule organization(GO:0030953)
0.1 7.5 GO:0051607 defense response to virus(GO:0051607)
0.1 3.5 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.1 9.5 GO:0007286 spermatid development(GO:0007286)
0.1 0.5 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.1 0.6 GO:0071474 cellular hyperosmotic response(GO:0071474)
0.1 0.2 GO:0060809 mesodermal to mesenchymal transition involved in gastrulation(GO:0060809)
0.1 0.6 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.1 0.5 GO:0042126 nitrate metabolic process(GO:0042126)
0.1 1.5 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236)
0.1 0.9 GO:0046321 positive regulation of fatty acid oxidation(GO:0046321)
0.1 5.0 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.1 3.5 GO:0006998 nuclear envelope organization(GO:0006998)
0.1 1.1 GO:0051092 positive regulation of NF-kappaB transcription factor activity(GO:0051092)
0.0 1.8 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.6 GO:0046688 response to copper ion(GO:0046688)
0.0 6.8 GO:0007416 synapse assembly(GO:0007416)
0.0 0.7 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.0 1.0 GO:0060765 regulation of androgen receptor signaling pathway(GO:0060765)
0.0 0.9 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 0.6 GO:0042088 T-helper 1 type immune response(GO:0042088)
0.0 2.3 GO:0000045 autophagosome assembly(GO:0000045)
0.0 0.1 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.0 2.2 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 0.7 GO:0046677 response to antibiotic(GO:0046677)
0.0 3.3 GO:0060047 heart contraction(GO:0060047)
0.0 0.7 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.0 0.7 GO:0001525 angiogenesis(GO:0001525)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
6.2 18.5 GO:1990682 CSF1-CSF1R complex(GO:1990682)
1.3 5.2 GO:0008537 proteasome activator complex(GO:0008537)
1.2 18.6 GO:0043083 synaptic cleft(GO:0043083)
1.0 4.0 GO:0031084 BLOC-2 complex(GO:0031084)
1.0 5.8 GO:0044530 supraspliceosomal complex(GO:0044530)
0.9 13.8 GO:0044754 autolysosome(GO:0044754)
0.9 4.6 GO:0043020 NADPH oxidase complex(GO:0043020)
0.9 6.1 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.9 5.2 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.8 3.3 GO:0016012 sarcoglycan complex(GO:0016012)
0.8 7.1 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.7 5.2 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.6 27.5 GO:0005637 nuclear inner membrane(GO:0005637)
0.6 5.0 GO:0097165 nuclear stress granule(GO:0097165)
0.5 3.3 GO:0042825 TAP complex(GO:0042825)
0.5 50.7 GO:0016363 nuclear matrix(GO:0016363)
0.4 2.4 GO:0097443 sorting endosome(GO:0097443)
0.4 1.9 GO:1990745 EARP complex(GO:1990745)
0.4 1.5 GO:1990111 spermatoproteasome complex(GO:1990111)
0.4 2.8 GO:0042629 mast cell granule(GO:0042629)
0.3 2.4 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.3 3.7 GO:0005640 nuclear outer membrane(GO:0005640)
0.3 13.9 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.3 2.5 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.3 3.5 GO:0020003 symbiont-containing vacuole(GO:0020003)
0.3 12.5 GO:0016235 aggresome(GO:0016235)
0.2 4.9 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.2 1.9 GO:0000815 ESCRT III complex(GO:0000815)
0.2 0.9 GO:1990357 terminal web(GO:1990357)
0.1 2.2 GO:0005614 interstitial matrix(GO:0005614)
0.1 3.3 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.1 12.8 GO:0005923 bicellular tight junction(GO:0005923)
0.1 4.4 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 37.3 GO:0045177 apical part of cell(GO:0045177)
0.1 5.5 GO:0031901 early endosome membrane(GO:0031901)
0.1 10.8 GO:0032587 ruffle membrane(GO:0032587)
0.1 1.0 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 11.6 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 1.8 GO:0005771 multivesicular body(GO:0005771)
0.1 3.0 GO:0008180 COP9 signalosome(GO:0008180)
0.1 0.7 GO:0000439 core TFIIH complex(GO:0000439)
0.1 15.2 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 0.5 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.1 21.1 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.6 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 3.5 GO:0005643 nuclear pore(GO:0005643)
0.0 0.9 GO:0005581 collagen trimer(GO:0005581)
0.0 1.3 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 8.7 GO:0043235 receptor complex(GO:0043235)
0.0 32.2 GO:0005730 nucleolus(GO:0005730)
0.0 2.3 GO:0005776 autophagosome(GO:0005776)
0.0 19.1 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 15.3 GO:0009986 cell surface(GO:0009986)
0.0 5.2 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 9.7 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 4.4 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 3.6 GO:0036064 ciliary basal body(GO:0036064)
0.0 3.0 GO:0030427 site of polarized growth(GO:0030427)
0.0 37.6 GO:0005739 mitochondrion(GO:0005739)
0.0 1.2 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 8.9 GO:0005615 extracellular space(GO:0005615)
0.0 75.2 GO:0005634 nucleus(GO:0005634)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.1 16.5 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
3.6 10.8 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
3.6 10.8 GO:0005110 frizzled-2 binding(GO:0005110)
3.0 9.0 GO:0004127 cytidylate kinase activity(GO:0004127) uridylate kinase activity(GO:0009041)
2.7 18.6 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
2.3 11.3 GO:0005030 neurotrophin receptor activity(GO:0005030)
2.2 8.8 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
2.1 8.5 GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483)
2.1 8.2 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
1.9 5.7 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
1.6 4.7 GO:0003692 left-handed Z-DNA binding(GO:0003692)
1.3 11.3 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
1.2 27.5 GO:0005521 lamin binding(GO:0005521)
1.1 4.6 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
1.0 21.9 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
1.0 5.1 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.8 3.3 GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982)
0.8 4.0 GO:0050700 CARD domain binding(GO:0050700)
0.8 3.1 GO:0038049 glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.7 2.2 GO:0070052 collagen V binding(GO:0070052)
0.7 7.4 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.7 2.8 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.7 4.0 GO:0001069 regulatory region RNA binding(GO:0001069)
0.7 50.7 GO:0019843 rRNA binding(GO:0019843)
0.7 9.8 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.6 1.8 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.6 2.4 GO:0019863 IgE binding(GO:0019863)
0.6 5.2 GO:0061133 endopeptidase activator activity(GO:0061133)
0.5 3.3 GO:0046978 TAP1 binding(GO:0046978) TAP2 binding(GO:0046979)
0.5 7.1 GO:0031386 protein tag(GO:0031386)
0.5 1.5 GO:0019153 protein-disulfide reductase (glutathione) activity(GO:0019153)
0.5 6.4 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.5 91.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.5 0.5 GO:0098809 nitrite reductase activity(GO:0098809)
0.5 1.4 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor(GO:0050664)
0.5 5.5 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.4 5.2 GO:0050897 cobalt ion binding(GO:0050897)
0.4 4.4 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.4 3.7 GO:0043495 protein anchor(GO:0043495)
0.4 3.3 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.3 5.8 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.3 1.6 GO:0004359 glutaminase activity(GO:0004359)
0.3 11.9 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.3 0.9 GO:0070890 L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890)
0.3 6.6 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.3 4.9 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.3 9.9 GO:0070412 R-SMAD binding(GO:0070412)
0.2 12.7 GO:0016836 hydro-lyase activity(GO:0016836)
0.2 4.4 GO:0005044 scavenger receptor activity(GO:0005044)
0.2 0.9 GO:0039706 co-receptor binding(GO:0039706)
0.2 0.6 GO:0048019 receptor antagonist activity(GO:0048019)
0.2 4.3 GO:0070566 adenylyltransferase activity(GO:0070566)
0.2 19.6 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.2 3.6 GO:0043422 protein kinase B binding(GO:0043422)
0.2 18.5 GO:0008083 growth factor activity(GO:0008083)
0.2 12.5 GO:0046332 SMAD binding(GO:0046332)
0.2 5.0 GO:0017091 AU-rich element binding(GO:0017091)
0.2 0.6 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.2 1.4 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.1 1.9 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.1 4.4 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 0.6 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 2.5 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 11.4 GO:0003727 single-stranded RNA binding(GO:0003727)
0.1 9.6 GO:0042826 histone deacetylase binding(GO:0042826)
0.1 4.2 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 0.9 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 0.7 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 8.5 GO:0030674 protein binding, bridging(GO:0030674)
0.1 0.5 GO:0097322 7SK snRNA binding(GO:0097322)
0.1 1.7 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.1 26.6 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 12.9 GO:0001664 G-protein coupled receptor binding(GO:0001664)
0.1 10.5 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 16.8 GO:0003924 GTPase activity(GO:0003924)
0.1 7.0 GO:0005057 receptor signaling protein activity(GO:0005057)
0.1 3.6 GO:0008013 beta-catenin binding(GO:0008013)
0.0 8.2 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 1.8 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.7 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 4.1 GO:0001067 regulatory region nucleic acid binding(GO:0001067)
0.0 1.0 GO:0070064 proline-rich region binding(GO:0070064)
0.0 1.0 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 1.8 GO:0032947 protein complex scaffold(GO:0032947)
0.0 2.6 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.0 1.6 GO:0008276 protein methyltransferase activity(GO:0008276)
0.0 1.3 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 0.2 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 3.6 GO:0008017 microtubule binding(GO:0008017)
0.0 4.2 GO:0003712 transcription cofactor activity(GO:0003712)
0.0 5.3 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 18.5 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.5 8.8 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.5 4.5 ST_TYPE_I_INTERFERON_PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.4 10.8 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.3 7.6 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.3 16.9 PID_SHP2_PATHWAY SHP2 signaling
0.2 5.2 PID_MYC_PATHWAY C-MYC pathway
0.2 6.4 PID_IL1_PATHWAY IL1-mediated signaling events
0.2 3.0 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.2 16.6 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.2 4.6 PID_RAC1_PATHWAY RAC1 signaling pathway
0.2 5.2 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 2.4 SIG_CHEMOTAXIS Genes related to chemotaxis
0.1 4.1 PID_TCPTP_PATHWAY Signaling events mediated by TCPTP
0.1 6.0 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.1 10.7 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 11.9 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.1 7.5 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.1 3.9 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 6.4 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 0.6 PID_IL12_2PATHWAY IL12-mediated signaling events
0.1 2.4 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 1.9 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 1.1 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.9 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 1.7 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 2.2 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.7 PID_LKB1_PATHWAY LKB1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
3.4 137.8 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
1.3 18.8 REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.8 18.6 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.6 5.0 REACTOME_PD1_SIGNALING Genes involved in PD-1 signaling
0.3 6.4 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.3 8.8 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.2 9.4 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.2 6.9 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
0.2 5.9 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.2 8.2 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.2 1.7 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.2 1.4 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism
0.1 10.4 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.3 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 1.6 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.1 4.4 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
0.1 3.1 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 0.6 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.1 1.9 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 5.1 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION Genes involved in Downstream signal transduction
0.0 1.3 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.6 REACTOME_IRON_UPTAKE_AND_TRANSPORT Genes involved in Iron uptake and transport
0.0 3.4 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.0 2.3 REACTOME_TOLL_RECEPTOR_CASCADES Genes involved in Toll Receptor Cascades
0.0 0.7 REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER Genes involved in Formation of incision complex in GG-NER
0.0 0.5 REACTOME_ELONGATION_ARREST_AND_RECOVERY Genes involved in Elongation arrest and recovery
0.0 0.9 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.9 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.8 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes