Motif ID: Hoxa11_Hoxc12

Z-value: 1.093

Transcription factors associated with Hoxa11_Hoxc12:

Gene SymbolEntrez IDGene Name
Hoxa11 ENSMUSG00000038210.9 Hoxa11
Hoxc12 ENSMUSG00000050328.2 Hoxc12






Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa11_Hoxc12

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_35076902 15.933 ENSMUST00000172494.1
ENSMUST00000172678.1
ENSMUST00000013910.4
Ly6g6e


lymphocyte antigen 6 complex, locus G6E


chr1_+_43730593 8.692 ENSMUST00000027217.8
1500015O10Rik
RIKEN cDNA 1500015O10 gene
chr1_-_56978534 8.560 ENSMUST00000177282.1
Satb2
special AT-rich sequence binding protein 2
chr14_+_80000292 7.358 ENSMUST00000088735.3
Olfm4
olfactomedin 4
chr17_+_6270475 6.869 ENSMUST00000088940.4
Tmem181a
transmembrane protein 181A
chr6_+_108213086 6.554 ENSMUST00000032192.6
Itpr1
inositol 1,4,5-trisphosphate receptor 1
chr17_-_6477102 5.267 ENSMUST00000167717.2
Tmem181b-ps
transmembrane protein 181B, pseudogene
chr16_-_57231434 4.894 ENSMUST00000023431.6
Tbc1d23
TBC1 domain family, member 23
chr13_+_16014457 4.656 ENSMUST00000164993.1
Inhba
inhibin beta-A
chr18_+_69346143 4.430 ENSMUST00000114980.1
Tcf4
transcription factor 4
chr15_-_43869993 4.382 ENSMUST00000067469.4
Tmem74
transmembrane protein 74
chr11_-_62457772 3.768 ENSMUST00000127471.2
Ncor1
nuclear receptor co-repressor 1
chr17_+_22361453 3.499 ENSMUST00000149699.1
ENSMUST00000088765.2
ENSMUST00000072477.4
ENSMUST00000121315.1
Zfp758



zinc finger protein 758



chr5_+_66968961 3.125 ENSMUST00000132991.1
Limch1
LIM and calponin homology domains 1
chrX_+_73064787 3.044 ENSMUST00000060418.6
Pnma3
paraneoplastic antigen MA3
chrX_+_41401128 2.788 ENSMUST00000115103.2
Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chr18_+_37655891 2.631 ENSMUST00000097608.2
3222401L13Rik
RIKEN cDNA 3222401L13 gene
chrX_+_41401304 2.576 ENSMUST00000076349.5
Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chr16_-_45408955 2.561 ENSMUST00000163230.1
Cd200
CD200 antigen
chr16_-_74411776 2.479 ENSMUST00000116586.2
Robo2
roundabout homolog 2 (Drosophila)
chr2_-_180824596 2.349 ENSMUST00000148700.1
Gm14340
predicted gene 14340
chr7_-_142661858 2.281 ENSMUST00000145896.2
Igf2
insulin-like growth factor 2
chr7_+_4460687 2.243 ENSMUST00000167298.1
ENSMUST00000171445.1
Eps8l1

EPS8-like 1

chr9_-_55919605 2.138 ENSMUST00000037408.8
Scaper
S phase cyclin A-associated protein in the ER
chr14_+_27622433 2.128 ENSMUST00000090302.5
Erc2
ELKS/RAB6-interacting/CAST family member 2
chr7_-_73537621 1.943 ENSMUST00000172704.1
Chd2
chromodomain helicase DNA binding protein 2
chr19_+_58943413 1.940 ENSMUST00000054280.6
Eno4
enolase 4
chrX_+_20364481 1.936 ENSMUST00000033372.6
ENSMUST00000115391.1
ENSMUST00000115387.1
Rp2h


retinitis pigmentosa 2 homolog (human)


chr3_-_117360876 1.815 ENSMUST00000061071.8
D3Bwg0562e
DNA segment, Chr 3, Brigham & Women's Genetics 0562 expressed
chr11_-_115627948 1.814 ENSMUST00000154623.1
ENSMUST00000106503.3
ENSMUST00000141614.1
Slc25a19


solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19


chr19_+_5406815 1.679 ENSMUST00000174412.1
ENSMUST00000153017.2
4930481A15Rik

RIKEN cDNA 4930481A15 gene

chr18_-_43393346 1.671 ENSMUST00000025379.7
Dpysl3
dihydropyrimidinase-like 3
chr11_-_95309557 1.669 ENSMUST00000092766.5
ENSMUST00000072621.5
Kat7

K(lysine) acetyltransferase 7

chr17_+_8283762 1.655 ENSMUST00000155364.1
ENSMUST00000046754.8
ENSMUST00000124023.1
Mpc1


mitochondrial pyruvate carrier 1


chr4_+_102741287 1.629 ENSMUST00000097948.2
Sgip1
SH3-domain GRB2-like (endophilin) interacting protein 1
chr6_-_118455475 1.621 ENSMUST00000161519.1
ENSMUST00000069292.7
Zfp248

zinc finger protein 248

chr13_+_109685994 1.615 ENSMUST00000074103.5
Pde4d
phosphodiesterase 4D, cAMP specific
chr16_+_23224724 1.553 ENSMUST00000023601.7
St6gal1
beta galactoside alpha 2,6 sialyltransferase 1
chr9_+_3404058 1.551 ENSMUST00000027027.5
Cwf19l2
CWF19-like 2, cell cycle control (S. pombe)
chr8_-_69373914 1.523 ENSMUST00000095282.1
Gm10311
predicted gene 10311
chr13_-_12464925 1.513 ENSMUST00000124888.1
Lgals8
lectin, galactose binding, soluble 8
chr8_+_104250925 1.512 ENSMUST00000098464.4
Cklf
chemokine-like factor
chr3_+_66219909 1.454 ENSMUST00000029421.5
Ptx3
pentraxin related gene
chr11_-_115628125 1.406 ENSMUST00000155709.1
ENSMUST00000021089.4
Slc25a19

solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19

chr5_-_20951769 1.397 ENSMUST00000036489.5
Rsbn1l
round spermatid basic protein 1-like
chr18_+_37333853 1.366 ENSMUST00000061717.2
Pcdhb6
protocadherin beta 6
chr8_-_69625503 1.348 ENSMUST00000121886.1
Zfp868
zinc finger protein 868
chr4_-_129378116 1.327 ENSMUST00000030610.2
Zbtb8a
zinc finger and BTB domain containing 8a
chr16_-_23225334 1.321 ENSMUST00000055369.4
BC106179
cDNA sequence BC106179
chr3_+_32436376 1.305 ENSMUST00000108242.1
Pik3ca
phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
chr10_+_90071095 1.288 ENSMUST00000183109.1
Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr13_-_23430826 1.275 ENSMUST00000153753.1
ENSMUST00000141543.1
C230035I16Rik

RIKEN cDNA C230035I16 gene

chr1_-_93101825 1.270 ENSMUST00000112958.2
Kif1a
kinesin family member 1A
chr14_-_34503323 1.226 ENSMUST00000171343.1
Bmpr1a
bone morphogenetic protein receptor, type 1A
chr2_-_120970706 1.224 ENSMUST00000028728.5
Ubr1
ubiquitin protein ligase E3 component n-recognin 1
chr2_+_23068168 1.197 ENSMUST00000028121.7
ENSMUST00000114523.2
ENSMUST00000144088.1
Acbd5


acyl-Coenzyme A binding domain containing 5


chr11_-_115628260 1.188 ENSMUST00000178003.1
Slc25a19
solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19
chr2_+_28205648 1.059 ENSMUST00000102879.3
ENSMUST00000028177.4
Olfm1

olfactomedin 1

chr8_+_40307458 1.032 ENSMUST00000068999.7
Micu3
mitochondrial calcium uptake family, member 3
chr1_-_189922338 1.017 ENSMUST00000027897.7
Smyd2
SET and MYND domain containing 2
chr16_+_87354185 1.015 ENSMUST00000054442.4
ENSMUST00000118310.1
ENSMUST00000120284.1
ENSMUST00000118115.1
N6amt1



N-6 adenine-specific DNA methyltransferase 1 (putative)



chr11_+_77216180 1.011 ENSMUST00000037912.5
ENSMUST00000156488.1
Ssh2

slingshot homolog 2 (Drosophila)

chr16_-_16600533 0.989 ENSMUST00000159542.1
Fgd4
FYVE, RhoGEF and PH domain containing 4
chr5_-_73256555 0.970 ENSMUST00000101127.5
ENSMUST00000171179.1
Fryl
Fryl
furry homolog-like (Drosophila)
furry homolog-like (Drosophila)
chr18_-_46280820 0.883 ENSMUST00000025354.3
Pggt1b
protein geranylgeranyltransferase type I, beta subunit
chr12_+_78226627 0.820 ENSMUST00000110388.2
ENSMUST00000052472.4
Gphn

gephyrin

chr3_+_79885930 0.804 ENSMUST00000029567.8
Fam198b
family with sequence similarity 198, member B
chr6_-_55681257 0.797 ENSMUST00000044767.8
Neurod6
neurogenic differentiation 6
chr8_+_31150307 0.787 ENSMUST00000098842.2
Tti2
TELO2 interacting protein 2
chr7_+_100372224 0.782 ENSMUST00000051777.8
ENSMUST00000098259.4
C2cd3

C2 calcium-dependent domain containing 3

chr13_+_98263105 0.748 ENSMUST00000150916.1
Ankra2
ankyrin repeat, family A (RFXANK-like), 2
chr13_+_98263242 0.746 ENSMUST00000022164.8
ENSMUST00000150352.1
Ankra2

ankyrin repeat, family A (RFXANK-like), 2

chr2_-_104712122 0.724 ENSMUST00000111118.1
ENSMUST00000028597.3
Tcp11l1

t-complex 11 like 1

chr7_-_46795661 0.712 ENSMUST00000123725.1
Hps5
Hermansky-Pudlak syndrome 5 homolog (human)
chr13_+_98263187 0.680 ENSMUST00000091356.3
ENSMUST00000123924.1
Ankra2

ankyrin repeat, family A (RFXANK-like), 2

chr11_-_62789402 0.605 ENSMUST00000108705.1
Zfp286
zinc finger protein 286
chr10_-_120979327 0.575 ENSMUST00000119944.1
ENSMUST00000119093.1
Lemd3

LEM domain containing 3

chr6_-_87809757 0.555 ENSMUST00000032134.7
Rab43
RAB43, member RAS oncogene family
chr3_+_129532386 0.552 ENSMUST00000071402.2
Elovl6
ELOVL family member 6, elongation of long chain fatty acids (yeast)
chr6_+_42286709 0.549 ENSMUST00000163936.1
Clcn1
chloride channel 1
chr5_-_116024475 0.525 ENSMUST00000111999.1
Prkab1
protein kinase, AMP-activated, beta 1 non-catalytic subunit
chr14_-_104522615 0.518 ENSMUST00000022716.2
Rnf219
ring finger protein 219
chr3_+_88621102 0.505 ENSMUST00000029694.7
ENSMUST00000176804.1
Arhgef2

rho/rac guanine nucleotide exchange factor (GEF) 2

chr11_-_62789445 0.493 ENSMUST00000054654.6
Zfp286
zinc finger protein 286
chr4_+_108328136 0.476 ENSMUST00000131656.1
Selrc1
Sel1 repeat containing 1
chr12_-_20900867 0.472 ENSMUST00000079237.5
Zfp125
zinc finger protein 125
chr16_+_96235801 0.462 ENSMUST00000113800.2
B3galt5
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5
chr6_+_42286676 0.455 ENSMUST00000031894.6
Clcn1
chloride channel 1
chr6_+_149141513 0.451 ENSMUST00000047531.9
ENSMUST00000179873.1
ENSMUST00000111548.1
ENSMUST00000111547.1
ENSMUST00000134306.1
Mettl20




methyltransferase like 20




chr7_-_46795881 0.443 ENSMUST00000107653.1
ENSMUST00000107654.1
ENSMUST00000014562.7
ENSMUST00000152759.1
Hps5



Hermansky-Pudlak syndrome 5 homolog (human)



chr12_+_59066908 0.410 ENSMUST00000021381.4
Pnn
pinin
chr6_+_149141638 0.400 ENSMUST00000166416.1
ENSMUST00000111551.1
Mettl20

methyltransferase like 20

chr1_+_182409162 0.399 ENSMUST00000117245.1
Trp53bp2
transformation related protein 53 binding protein 2
chr13_-_66851513 0.378 ENSMUST00000169322.1
Gm17404
predicted gene, 17404
chr11_+_55213783 0.364 ENSMUST00000108867.1
Slc36a1
solute carrier family 36 (proton/amino acid symporter), member 1
chr10_-_19011948 0.345 ENSMUST00000105527.1
Tnfaip3
tumor necrosis factor, alpha-induced protein 3
chr17_-_24455265 0.328 ENSMUST00000056032.7
E4f1
E4F transcription factor 1
chr16_+_75592844 0.327 ENSMUST00000114249.1
ENSMUST00000046378.7
ENSMUST00000114253.1
Rbm11


RNA binding motif protein 11


chr12_-_27160311 0.315 ENSMUST00000182473.1
ENSMUST00000177636.1
ENSMUST00000183238.1
Gm9866


predicted gene 9866


chr1_+_178529113 0.271 ENSMUST00000161017.1
Kif26b
kinesin family member 26B
chr5_-_143292356 0.269 ENSMUST00000180336.1
Zfp853
zinc finger protein 853
chr11_-_23895208 0.256 ENSMUST00000102863.2
ENSMUST00000020513.3
Papolg

poly(A) polymerase gamma

chrX_-_7319291 0.220 ENSMUST00000128319.1
Clcn5
chloride channel 5
chr11_-_72267141 0.216 ENSMUST00000137701.1
Slc13a5
solute carrier family 13 (sodium-dependent citrate transporter), member 5
chr4_+_130913120 0.214 ENSMUST00000151698.1
Laptm5
lysosomal-associated protein transmembrane 5
chr7_-_119895446 0.210 ENSMUST00000098080.2
Dcun1d3
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr8_+_105225145 0.199 ENSMUST00000034361.3
D230025D16Rik
RIKEN cDNA D230025D16 gene
chr4_+_130913264 0.199 ENSMUST00000156225.1
ENSMUST00000156742.1
Laptm5

lysosomal-associated protein transmembrane 5

chr13_+_58281183 0.152 ENSMUST00000180882.1
ENSMUST00000180452.1
Gm26555

predicted gene, 26555

chr3_-_142881942 0.150 ENSMUST00000043812.8
Pkn2
protein kinase N2
chrX_-_165004829 0.149 ENSMUST00000114890.2
Gm17604
predicted gene, 17604
chr5_+_3543812 0.135 ENSMUST00000115527.3
Fam133b
family with sequence similarity 133, member B
chr5_+_32611171 0.134 ENSMUST00000072311.6
ENSMUST00000168707.2
Yes1

Yamaguchi sarcoma viral (v-yes) oncogene homolog 1

chr4_+_107889813 0.130 ENSMUST00000135454.1
ENSMUST00000106726.3
ENSMUST00000106727.3
ENSMUST00000119394.1
ENSMUST00000120473.1
ENSMUST00000125107.1
ENSMUST00000128474.1
0610037L13Rik






RIKEN cDNA 0610037L13 gene






chr11_-_5542177 0.117 ENSMUST00000020776.4
Ccdc117
coiled-coil domain containing 117
chr12_-_23780265 0.114 ENSMUST00000072014.4
Gm10330
predicted gene 10330
chr6_+_40325471 0.113 ENSMUST00000031977.8
Agk
acylglycerol kinase
chr19_-_7483212 0.088 ENSMUST00000088169.5
Rtn3
reticulon 3
chr5_-_116024452 0.058 ENSMUST00000031486.7
Prkab1
protein kinase, AMP-activated, beta 1 non-catalytic subunit
chr13_-_35027077 0.057 ENSMUST00000170538.1
ENSMUST00000163280.1
Eci2

enoyl-Coenzyme A delta isomerase 2

chr13_-_99344652 0.053 ENSMUST00000022153.6
Ptcd2
pentatricopeptide repeat domain 2
chr2_+_166805506 0.032 ENSMUST00000099078.3
Arfgef2
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
chr7_-_141435327 0.001 ENSMUST00000138865.1
Slc25a22
solute carrier family 25 (mitochondrial carrier, glutamate), member 22
chr13_-_66852017 0.001 ENSMUST00000059329.6
Gm17449
predicted gene, 17449

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.4 GO:0030974 thiamine pyrophosphate transport(GO:0030974)
1.1 6.9 GO:0009405 pathogenesis(GO:0009405)
1.1 6.6 GO:0042045 epithelial fluid transport(GO:0042045)
1.1 8.7 GO:0070314 G1 to G0 transition(GO:0070314)
0.9 3.8 GO:0072362 regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072362)
0.9 4.7 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.9 2.6 GO:0043031 negative regulation of macrophage activation(GO:0043031)
0.8 2.5 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.6 1.7 GO:0072720 response to sorbitol(GO:0072708) response to dithiothreitol(GO:0072720)
0.5 15.9 GO:0022401 desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) negative adaptation of signaling pathway(GO:0022401)
0.5 8.6 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.4 1.3 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.4 1.7 GO:1901475 pyruvate transmembrane transport(GO:1901475)
0.4 1.2 GO:0021998 neural plate mediolateral regionalization(GO:0021998) mesoderm structural organization(GO:0048338) paraxial mesoderm structural organization(GO:0048352) positive regulation of cardiac ventricle development(GO:1904414)
0.4 4.4 GO:0042118 endothelial cell activation(GO:0042118)
0.4 1.6 GO:2000110 protein sialylation(GO:1990743) negative regulation of macrophage apoptotic process(GO:2000110)
0.3 2.2 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.3 1.2 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.3 0.9 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.3 1.5 GO:0052428 modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
0.3 2.3 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.3 1.5 GO:0002317 plasma cell differentiation(GO:0002317)
0.2 0.6 GO:0035526 retrograde transport, plasma membrane to Golgi(GO:0035526)
0.2 1.6 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.2 1.2 GO:0030242 pexophagy(GO:0030242)
0.2 0.8 GO:0006777 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720)
0.2 7.4 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.2 0.8 GO:0061511 centriole elongation(GO:0061511)
0.1 1.0 GO:0090527 actin filament reorganization(GO:0090527)
0.1 1.0 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.1 5.4 GO:0001919 regulation of receptor recycling(GO:0001919)
0.1 1.6 GO:1901898 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 0.3 GO:0070428 granuloma formation(GO:0002432) negative regulation of toll-like receptor 3 signaling pathway(GO:0034140) toll-like receptor 5 signaling pathway(GO:0034146) regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428) regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070432)
0.1 0.6 GO:0070197 meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240)
0.1 1.0 GO:0030035 microspike assembly(GO:0030035)
0.1 1.3 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.1 1.0 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 0.6 GO:0035878 nail development(GO:0035878)
0.1 1.1 GO:0023041 neuronal signal transduction(GO:0023041)
0.1 1.3 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.1 0.3 GO:0072092 ureteric bud invasion(GO:0072092) metanephric renal vesicle formation(GO:0072093)
0.1 1.7 GO:0051764 actin crosslink formation(GO:0051764)
0.1 5.4 GO:0032755 positive regulation of interleukin-6 production(GO:0032755)
0.1 1.2 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.1 0.3 GO:0009794 regulation of mitotic cell cycle, embryonic(GO:0009794) mitotic cell cycle, embryonic(GO:0045448)
0.1 0.2 GO:0015744 succinate transport(GO:0015744)
0.1 0.4 GO:0015808 L-alanine transport(GO:0015808)
0.1 0.6 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 1.5 GO:0048246 macrophage chemotaxis(GO:0048246)
0.0 1.4 GO:0009988 cell-cell recognition(GO:0009988)
0.0 1.9 GO:0030317 sperm motility(GO:0030317)
0.0 0.8 GO:0021542 dentate gyrus development(GO:0021542)
0.0 1.0 GO:0010591 regulation of lamellipodium assembly(GO:0010591)
0.0 0.4 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.0 0.5 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 4.4 GO:0016236 macroautophagy(GO:0016236)
0.0 3.1 GO:0031032 actomyosin structure organization(GO:0031032)
0.0 0.2 GO:0010225 response to UV-C(GO:0010225)
0.0 0.1 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.0 0.1 GO:0036120 response to platelet-derived growth factor(GO:0036119) cellular response to platelet-derived growth factor stimulus(GO:0036120)
0.0 1.2 GO:0043473 pigmentation(GO:0043473)
0.0 0.3 GO:0043631 mRNA polyadenylation(GO:0006378) RNA polyadenylation(GO:0043631)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 6.6 GO:0031088 platelet dense granule membrane(GO:0031088)
1.6 4.7 GO:0043512 inhibin A complex(GO:0043512)
0.5 8.7 GO:0031045 dense core granule(GO:0031045)
0.5 7.4 GO:0042581 specific granule(GO:0042581)
0.4 1.3 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.4 2.2 GO:1990393 3M complex(GO:1990393)
0.4 5.4 GO:0043083 synaptic cleft(GO:0043083)
0.3 1.2 GO:0031084 BLOC-2 complex(GO:0031084)
0.2 1.9 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.2 6.1 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.2 3.8 GO:0016580 Sin3 complex(GO:0016580)
0.2 1.6 GO:0000138 Golgi trans cisterna(GO:0000138)
0.1 1.6 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 8.6 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 2.5 GO:0030673 axolemma(GO:0030673)
0.0 2.1 GO:0048786 presynaptic active zone(GO:0048786)
0.0 1.6 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.6 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.6 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.8 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.4 GO:0030057 desmosome(GO:0030057)
0.0 1.7 GO:0031941 filamentous actin(GO:0031941)
0.0 1.0 GO:0034707 chloride channel complex(GO:0034707)
0.0 1.1 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.8 GO:0034451 centriolar satellite(GO:0034451)
0.0 2.7 GO:0032587 ruffle membrane(GO:0032587)
0.0 2.6 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 1.7 GO:0000123 histone acetyltransferase complex(GO:0000123)
0.0 1.2 GO:0005901 caveola(GO:0005901)
0.0 1.2 GO:0000502 proteasome complex(GO:0000502)
0.0 0.6 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 1.0 GO:0030175 filopodium(GO:0030175)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
5.3 15.9 GO:0030549 acetylcholine receptor activator activity(GO:0030549)
2.2 6.6 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
1.1 4.4 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.8 4.7 GO:0070699 type II activin receptor binding(GO:0070699)
0.8 5.4 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.7 4.4 GO:0015234 thiamine transmembrane transporter activity(GO:0015234)
0.5 6.9 GO:0015643 toxic substance binding(GO:0015643)
0.5 3.8 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.4 1.7 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.3 1.6 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.3 2.5 GO:0008046 axon guidance receptor activity(GO:0008046)
0.2 1.9 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.2 1.5 GO:0001849 complement component C1q binding(GO:0001849)
0.2 0.8 GO:0043546 molybdopterin cofactor binding(GO:0043546)
0.2 1.2 GO:0070728 leucine binding(GO:0070728)
0.2 1.7 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.2 0.9 GO:0004661 protein geranylgeranyltransferase activity(GO:0004661)
0.2 1.2 GO:0098821 BMP receptor activity(GO:0098821)
0.2 1.0 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.2 1.3 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.1 0.4 GO:0015173 hydrogen:amino acid symporter activity(GO:0005280) aromatic amino acid transmembrane transporter activity(GO:0015173)
0.1 1.7 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 2.2 GO:0042608 T cell receptor binding(GO:0042608)
0.1 1.2 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 2.3 GO:0043539 insulin-like growth factor receptor binding(GO:0005159) protein serine/threonine kinase activator activity(GO:0043539)
0.1 0.2 GO:0017153 sodium:dicarboxylate symporter activity(GO:0017153)
0.1 2.2 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.1 0.6 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.1 0.6 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.3 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 1.6 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 1.2 GO:0008009 chemokine activity(GO:0008009)
0.0 1.3 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.1 GO:0001729 ceramide kinase activity(GO:0001729)
0.0 0.3 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 1.3 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 1.1 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 1.0 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 9.5 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 2.3 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.3 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.3 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 1.0 GO:0008276 protein methyltransferase activity(GO:0008276)
0.0 0.5 GO:0008378 galactosyltransferase activity(GO:0008378)
0.0 0.4 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 1.9 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.0 1.0 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 6.8 GO:0003682 chromatin binding(GO:0003682)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.1 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 4.7 PID_ALK1_PATHWAY ALK1 signaling events
0.1 5.1 PID_ERBB4_PATHWAY ErbB4 signaling events
0.1 1.5 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 2.3 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 2.2 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 3.2 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.2 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.7 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 0.3 PID_CD40_PATHWAY CD40/CD40L signaling
0.0 0.5 PID_REELIN_PATHWAY Reelin signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.7 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.2 5.4 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.2 1.6 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 2.3 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 3.8 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 4.4 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 1.7 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 2.5 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.1 1.3 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.6 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 1.2 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 1.6 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 0.2 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.6 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 1.5 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 0.8 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.3 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.4 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane