Motif ID: Tal1

Z-value: 0.832


Transcription factors associated with Tal1:

Gene SymbolEntrez IDGene Name
Tal1 ENSMUSG00000028717.6 Tal1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tal1mm10_v2_chr4_+_115059507_115059553-0.086.3e-01Click!


Activity profile for motif Tal1.

activity profile for motif Tal1


Sorted Z-values histogram for motif Tal1

Sorted Z-values for motif Tal1



Network of associatons between targets according to the STRING database.



First level regulatory network of Tal1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_103853199 12.019 ENSMUST00000033229.3
Hbb-y
hemoglobin Y, beta-like embryonic chain
chr11_+_32276400 6.464 ENSMUST00000020531.2
Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
chr11_+_32276893 6.224 ENSMUST00000145569.1
Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
chr9_+_57998036 2.647 ENSMUST00000181289.1
Gm17322
predicted gene, 17322
chr3_-_33083016 2.395 ENSMUST00000078226.3
ENSMUST00000108224.1
Pex5l

peroxisomal biogenesis factor 5-like

chr16_-_18621366 2.277 ENSMUST00000051160.2
Gp1bb
glycoprotein Ib, beta polypeptide
chr10_-_11082287 2.219 ENSMUST00000105561.2
ENSMUST00000044306.6
Grm1

glutamate receptor, metabotropic 1

chr11_+_78115565 2.163 ENSMUST00000155571.1
Fam222b
family with sequence similarity 222, member B
chr8_-_71511762 2.133 ENSMUST00000048452.4
Plvap
plasmalemma vesicle associated protein
chr8_+_45658666 2.074 ENSMUST00000134675.1
ENSMUST00000139869.1
ENSMUST00000126067.1
Sorbs2


sorbin and SH3 domain containing 2


chr1_+_169969409 1.950 ENSMUST00000180638.1
3110045C21Rik
RIKEN cDNA 3110045C21 gene
chr6_-_72235559 1.923 ENSMUST00000042646.7
Atoh8
atonal homolog 8 (Drosophila)
chr19_+_20601958 1.851 ENSMUST00000087638.3
Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
chr8_-_125898291 1.761 ENSMUST00000047239.6
Pcnxl2
pecanex-like 2 (Drosophila)
chr10_+_97565436 1.738 ENSMUST00000038160.4
Lum
lumican
chr1_+_109982710 1.665 ENSMUST00000112701.1
Cdh7
cadherin 7, type 2
chr1_+_109983006 1.640 ENSMUST00000145188.1
Cdh7
cadherin 7, type 2
chr7_+_119900099 1.583 ENSMUST00000106516.1
Lyrm1
LYR motif containing 1
chr8_+_45658273 1.538 ENSMUST00000153798.1
Sorbs2
sorbin and SH3 domain containing 2
chr19_+_42247544 1.499 ENSMUST00000122375.1
Golga7b
golgi autoantigen, golgin subfamily a, 7B
chr7_+_97842917 1.492 ENSMUST00000033040.5
Pak1
p21 protein (Cdc42/Rac)-activated kinase 1
chr1_-_132367879 1.406 ENSMUST00000142609.1
Tmcc2
transmembrane and coiled-coil domains 2
chr5_-_107972864 1.405 ENSMUST00000153172.1
Fam69a
family with sequence similarity 69, member A
chr19_+_24875679 1.338 ENSMUST00000073080.5
Gm10053
predicted gene 10053
chr2_-_79908428 1.274 ENSMUST00000102652.3
ENSMUST00000102651.3
Pde1a

phosphodiesterase 1A, calmodulin-dependent

chr4_+_82065924 1.269 ENSMUST00000161588.1
Gm5860
predicted gene 5860
chr10_+_116177351 1.168 ENSMUST00000155606.1
ENSMUST00000128399.1
Ptprr

protein tyrosine phosphatase, receptor type, R

chr15_+_89568322 1.162 ENSMUST00000023295.2
Acr
acrosin prepropeptide
chr5_-_24351604 0.965 ENSMUST00000036092.7
Kcnh2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr7_+_16875302 0.961 ENSMUST00000108493.1
Dact3
dapper homolog 3, antagonist of beta-catenin (xenopus)
chr4_+_102760294 0.951 ENSMUST00000072481.5
ENSMUST00000156596.1
ENSMUST00000080728.6
ENSMUST00000106882.2
Sgip1



SH3-domain GRB2-like (endophilin) interacting protein 1



chr15_-_83170498 0.947 ENSMUST00000162178.1
Cyb5r3
cytochrome b5 reductase 3
chr7_-_4630473 0.943 ENSMUST00000055085.6
Tmem86b
transmembrane protein 86B
chr6_-_127109517 0.931 ENSMUST00000039913.8
9630033F20Rik
RIKEN cDNA 9630033F20 gene
chr2_-_79908389 0.910 ENSMUST00000090756.4
Pde1a
phosphodiesterase 1A, calmodulin-dependent
chr2_+_138256530 0.906 ENSMUST00000091556.5
Btbd3
BTB (POZ) domain containing 3
chr1_-_173333503 0.905 ENSMUST00000038227.4
Darc
Duffy blood group, chemokine receptor
chr10_-_117224480 0.900 ENSMUST00000020382.6
Yeats4
YEATS domain containing 4
chr8_-_77517898 0.893 ENSMUST00000076316.4
Arhgap10
Rho GTPase activating protein 10
chr6_-_25809210 0.879 ENSMUST00000115330.1
ENSMUST00000115329.1
Pot1a

protection of telomeres 1A

chr11_+_94936224 0.852 ENSMUST00000001547.7
Col1a1
collagen, type I, alpha 1
chr9_-_111057235 0.798 ENSMUST00000111888.1
Ccrl2
chemokine (C-C motif) receptor-like 2
chr5_-_5265224 0.790 ENSMUST00000115450.1
Cdk14
cyclin-dependent kinase 14
chr16_-_45953565 0.764 ENSMUST00000134802.1
Phldb2
pleckstrin homology-like domain, family B, member 2
chr2_-_149798701 0.758 ENSMUST00000148202.1
ENSMUST00000139471.1
Gm14133

predicted gene 14133

chr19_-_46969474 0.744 ENSMUST00000086961.7
Nt5c2
5'-nucleotidase, cytosolic II
chr4_-_59438633 0.730 ENSMUST00000040166.7
ENSMUST00000107544.1
Susd1

sushi domain containing 1

chr7_-_44375006 0.725 ENSMUST00000107933.1
1700008O03Rik
RIKEN cDNA 1700008O03 gene
chr4_+_134864536 0.717 ENSMUST00000030627.7
Rhd
Rh blood group, D antigen
chr2_+_136892168 0.716 ENSMUST00000099311.2
Slx4ip
SLX4 interacting protein
chr8_-_36732897 0.709 ENSMUST00000098826.3
Dlc1
deleted in liver cancer 1
chr13_-_66227573 0.707 ENSMUST00000167981.2
Gm10772
predicted gene 10772
chr15_-_83170168 0.696 ENSMUST00000162834.1
Cyb5r3
cytochrome b5 reductase 3
chr11_+_58948890 0.686 ENSMUST00000078267.3
Hist3h2ba
histone cluster 3, H2ba
chr7_-_99238564 0.684 ENSMUST00000064231.7
Mogat2
monoacylglycerol O-acyltransferase 2
chr15_+_80623499 0.683 ENSMUST00000043149.7
Grap2
GRB2-related adaptor protein 2
chr12_-_81485073 0.677 ENSMUST00000166723.1
ENSMUST00000110340.2
ENSMUST00000168463.1
ENSMUST00000169124.1
ENSMUST00000002757.4
Cox16




cytochrome c oxidase assembly protein 16




chr2_-_153241402 0.675 ENSMUST00000056924.7
Plagl2
pleiomorphic adenoma gene-like 2
chr10_+_40883469 0.672 ENSMUST00000019975.7
Wasf1
WAS protein family, member 1
chr2_+_84839395 0.671 ENSMUST00000146816.1
ENSMUST00000028469.7
Slc43a1

solute carrier family 43, member 1

chr7_+_126760591 0.648 ENSMUST00000091328.2
Mapk3
mitogen-activated protein kinase 3
chr3_+_89136133 0.646 ENSMUST00000047111.6
Pklr
pyruvate kinase liver and red blood cell
chr17_-_29237759 0.626 ENSMUST00000137727.1
ENSMUST00000024805.7
Cpne5

copine V

chr2_+_30061754 0.622 ENSMUST00000149578.1
ENSMUST00000102866.3
Set

SET nuclear oncogene

chr3_+_133338936 0.619 ENSMUST00000150386.1
ENSMUST00000125858.1
Ppa2

pyrophosphatase (inorganic) 2

chr7_+_101317073 0.613 ENSMUST00000163799.2
ENSMUST00000164479.2
Stard10

START domain containing 10

chr9_-_62510498 0.609 ENSMUST00000164246.2
Coro2b
coronin, actin binding protein, 2B
chr3_+_89136572 0.597 ENSMUST00000107482.3
ENSMUST00000127058.1
Pklr

pyruvate kinase liver and red blood cell

chr19_-_7206234 0.596 ENSMUST00000123594.1
ENSMUST00000025679.4
Otub1

OTU domain, ubiquitin aldehyde binding 1

chrX_-_8193387 0.589 ENSMUST00000143223.1
ENSMUST00000033509.8
Ebp

phenylalkylamine Ca2+ antagonist (emopamil) binding protein

chr9_-_105521147 0.587 ENSMUST00000176770.1
ENSMUST00000085133.6
Atp2c1

ATPase, Ca++-sequestering

chr1_+_163779575 0.579 ENSMUST00000027877.6
ENSMUST00000077642.5
Kifap3

kinesin-associated protein 3

chr17_-_33713372 0.576 ENSMUST00000173392.1
March2
membrane-associated ring finger (C3HC4) 2
chr5_-_103911196 0.572 ENSMUST00000031254.2
Klhl8
kelch-like 8
chr7_-_18992774 0.559 ENSMUST00000098778.2
Gm10676
predicted gene 10676
chr15_-_103251465 0.540 ENSMUST00000133600.1
ENSMUST00000134554.1
ENSMUST00000156927.1
ENSMUST00000149111.1
ENSMUST00000132836.1
Nfe2




nuclear factor, erythroid derived 2




chr19_-_29367294 0.531 ENSMUST00000138051.1
Plgrkt
plasminogen receptor, C-terminal lysine transmembrane protein
chr6_+_86078070 0.530 ENSMUST00000032069.5
Add2
adducin 2 (beta)
chr12_-_81594958 0.516 ENSMUST00000002756.7
ENSMUST00000161598.1
ENSMUST00000161211.1
Med6


mediator of RNA polymerase II transcription, subunit 6 homolog (yeast)


chr8_+_40307458 0.512 ENSMUST00000068999.7
Micu3
mitochondrial calcium uptake family, member 3
chr13_+_90089705 0.508 ENSMUST00000012566.8
Tmem167
transmembrane protein 167
chr17_+_36869567 0.504 ENSMUST00000060524.9
Trim10
tripartite motif-containing 10
chr8_+_3587445 0.504 ENSMUST00000057028.7
ENSMUST00000171962.1
Camsap3

calmodulin regulated spectrin-associated protein family, member 3

chr16_-_46010212 0.501 ENSMUST00000130481.1
Plcxd2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr1_-_44101982 0.498 ENSMUST00000127923.1
Tex30
testis expressed 30
chr10_-_39133914 0.491 ENSMUST00000135785.1
Fam229b
family with sequence similarity 229, member B
chr6_-_25809189 0.485 ENSMUST00000115327.1
Pot1a
protection of telomeres 1A
chrX_+_56447965 0.479 ENSMUST00000079663.6
Gm2174
predicted gene 2174
chr1_-_44101661 0.464 ENSMUST00000152239.1
Tex30
testis expressed 30
chrX_+_93675088 0.457 ENSMUST00000045898.3
Pcyt1b
phosphate cytidylyltransferase 1, choline, beta isoform
chr1_+_135818593 0.453 ENSMUST00000038760.8
Lad1
ladinin
chr13_+_98263242 0.450 ENSMUST00000022164.8
ENSMUST00000150352.1
Ankra2

ankyrin repeat, family A (RFXANK-like), 2

chr9_-_60688118 0.448 ENSMUST00000114034.2
ENSMUST00000065603.5
Lrrc49

leucine rich repeat containing 49

chr9_+_44379490 0.416 ENSMUST00000066601.6
Hyou1
hypoxia up-regulated 1
chr7_-_105633479 0.399 ENSMUST00000147044.1
ENSMUST00000106791.1
Trim3

tripartite motif-containing 3

chrX_-_107403295 0.395 ENSMUST00000033591.5
Itm2a
integral membrane protein 2A
chr5_-_105239533 0.394 ENSMUST00000065588.6
Gbp10
guanylate-binding protein 10
chr11_-_98625661 0.391 ENSMUST00000104933.1
Gm12355
predicted gene 12355
chr2_+_127080252 0.384 ENSMUST00000142737.1
Blvra
biliverdin reductase A
chr16_-_45953493 0.381 ENSMUST00000136405.1
Phldb2
pleckstrin homology-like domain, family B, member 2
chrX_-_134111852 0.374 ENSMUST00000033610.6
Nox1
NADPH oxidase 1
chr17_+_40811089 0.366 ENSMUST00000024721.7
Rhag
Rhesus blood group-associated A glycoprotein
chr13_+_49682100 0.363 ENSMUST00000165316.1
ENSMUST00000047363.7
Iars

isoleucine-tRNA synthetase

chr5_-_105139539 0.360 ENSMUST00000100961.4
ENSMUST00000031235.6
ENSMUST00000100962.3
Gbp9
Gbp8
Gbp4
guanylate-binding protein 9
guanylate-binding protein 8
guanylate binding protein 4
chr10_-_93891141 0.359 ENSMUST00000180840.1
Metap2
methionine aminopeptidase 2
chr17_+_16972910 0.358 ENSMUST00000071374.5
BC002059
cDNA sequence BC002059
chr9_+_108290433 0.354 ENSMUST00000035227.6
Nicn1
nicolin 1
chr2_+_181864337 0.352 ENSMUST00000039551.8
Polr3k
polymerase (RNA) III (DNA directed) polypeptide K
chr17_-_24886304 0.334 ENSMUST00000044252.5
Nubp2
nucleotide binding protein 2
chr2_-_153015331 0.329 ENSMUST00000028972.8
Pdrg1
p53 and DNA damage regulated 1
chr5_-_105110292 0.326 ENSMUST00000031238.6
Gbp9
guanylate-binding protein 9
chr2_+_136891501 0.307 ENSMUST00000141463.1
Slx4ip
SLX4 interacting protein
chr12_-_72664759 0.296 ENSMUST00000021512.9
Dhrs7
dehydrogenase/reductase (SDR family) member 7
chr11_+_4986824 0.289 ENSMUST00000009234.9
ENSMUST00000109897.1
Ap1b1

adaptor protein complex AP-1, beta 1 subunit

chr11_+_65807175 0.288 ENSMUST00000071465.2
ENSMUST00000018491.7
Zkscan6

zinc finger with KRAB and SCAN domains 6

chr2_-_153225396 0.285 ENSMUST00000099194.2
Tspyl3
TSPY-like 3
chr13_+_66904914 0.274 ENSMUST00000168767.2
Gm10767
predicted gene 10767
chr19_+_29367447 0.264 ENSMUST00000016640.7
Cd274
CD274 antigen
chr8_-_105938384 0.262 ENSMUST00000034369.8
Psmb10
proteasome (prosome, macropain) subunit, beta type 10
chr18_-_43687695 0.254 ENSMUST00000082254.6
Jakmip2
janus kinase and microtubule interacting protein 2
chr10_+_39133981 0.251 ENSMUST00000019991.7
Tube1
epsilon-tubulin 1
chr8_+_80494032 0.251 ENSMUST00000063359.6
Gypa
glycophorin A
chr10_-_95324072 0.243 ENSMUST00000053594.5
Cradd
CASP2 and RIPK1 domain containing adaptor with death domain
chr10_+_53337686 0.241 ENSMUST00000046221.6
ENSMUST00000163319.1
Pln

phospholamban

chr12_+_95692212 0.239 ENSMUST00000057324.3
Flrt2
fibronectin leucine rich transmembrane protein 2
chr9_-_21963568 0.235 ENSMUST00000006397.5
Epor
erythropoietin receptor
chr4_+_41465134 0.216 ENSMUST00000030154.6
Nudt2
nudix (nucleoside diphosphate linked moiety X)-type motif 2
chr18_-_36726730 0.213 ENSMUST00000061829.6
Cd14
CD14 antigen
chr2_+_76369967 0.211 ENSMUST00000046389.4
Rbm45
RNA binding motif protein 45
chr7_+_131371138 0.209 ENSMUST00000075610.6
Pstk
phosphoseryl-tRNA kinase
chr17_+_34981847 0.201 ENSMUST00000114011.4
Lsm2
LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr13_-_13393592 0.191 ENSMUST00000021738.8
Gpr137b
G protein-coupled receptor 137B
chr14_-_43819639 0.191 ENSMUST00000100691.3
Ear1
eosinophil-associated, ribonuclease A family, member 1
chr5_+_29378604 0.186 ENSMUST00000181005.1
4632411P08Rik
RIKEN cDNA 4632411P08 gene
chr14_+_63860290 0.182 ENSMUST00000022528.4
Pinx1
PIN2/TERF1 interacting, telomerase inhibitor 1
chr13_+_55593135 0.181 ENSMUST00000109905.3
Tmed9
transmembrane emp24 protein transport domain containing 9
chr8_-_71537402 0.177 ENSMUST00000051672.7
Bst2
bone marrow stromal cell antigen 2
chr14_+_44102654 0.173 ENSMUST00000074839.6
Ear2
eosinophil-associated, ribonuclease A family, member 2
chr11_+_50225315 0.164 ENSMUST00000041725.7
Mgat4b
mannoside acetylglucosaminyltransferase 4, isoenzyme B
chr2_-_6951680 0.155 ENSMUST00000076071.2
Gm10115
predicted gene 10115
chr6_+_30541582 0.140 ENSMUST00000096066.4
Cpa2
carboxypeptidase A2, pancreatic
chrX_+_7579666 0.138 ENSMUST00000115740.1
ENSMUST00000115739.1
Foxp3

forkhead box P3

chr10_-_128626464 0.134 ENSMUST00000026420.5
Rps26
ribosomal protein S26
chr11_+_102393403 0.120 ENSMUST00000107105.2
ENSMUST00000107102.1
ENSMUST00000107103.1
ENSMUST00000006750.7
Rundc3a



RUN domain containing 3A



chr13_-_32781716 0.115 ENSMUST00000134352.1
ENSMUST00000057428.4
Mylk4

myosin light chain kinase family, member 4

chr14_+_55561060 0.113 ENSMUST00000117701.1
Dcaf11
DDB1 and CUL4 associated factor 11
chr5_-_105293699 0.108 ENSMUST00000050011.8
Gbp6
guanylate binding protein 6
chr10_+_41887428 0.103 ENSMUST00000041438.6
Sesn1
sestrin 1
chr11_+_58917889 0.101 ENSMUST00000069941.6
Btnl10
butyrophilin-like 10
chr2_+_69897220 0.092 ENSMUST00000055758.9
ENSMUST00000112251.2
Ubr3

ubiquitin protein ligase E3 component n-recognin 3

chr6_+_48647224 0.087 ENSMUST00000078223.3
Gimap8
GTPase, IMAP family member 8
chr19_-_19111181 0.076 ENSMUST00000112832.1
Rorb
RAR-related orphan receptor beta
chr4_-_56802265 0.073 ENSMUST00000030140.2
Ikbkap
inhibitor of kappa light polypeptide enhancer in B cells, kinase complex-associated protein
chr6_+_47877204 0.066 ENSMUST00000061890.7
Zfp282
zinc finger protein 282
chr13_-_90089556 0.056 ENSMUST00000022115.7
Xrcc4
X-ray repair complementing defective repair in Chinese hamster cells 4
chr18_+_24205303 0.052 ENSMUST00000000430.7
Galnt1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1
chr1_-_52232296 0.046 ENSMUST00000114512.1
Gls
glutaminase
chr2_+_85037448 0.037 ENSMUST00000168266.1
ENSMUST00000130729.1
Ssrp1

structure specific recognition protein 1

chr14_+_55560480 0.032 ENSMUST00000121622.1
ENSMUST00000143431.1
ENSMUST00000150481.1
Dcaf11


DDB1 and CUL4 associated factor 11


chr4_-_148159571 0.031 ENSMUST00000167160.1
ENSMUST00000151246.1
Fbxo44

F-box protein 44

chr2_-_136891363 0.020 ENSMUST00000028730.6
ENSMUST00000110089.2
Mkks

McKusick-Kaufman syndrome

chr3_+_88621436 0.014 ENSMUST00000170653.2
ENSMUST00000177303.1
Arhgef2

rho/rac guanine nucleotide exchange factor (GEF) 2

chr11_-_102469839 0.013 ENSMUST00000103086.3
Itga2b
integrin alpha 2b
chr8_+_107436355 0.001 ENSMUST00000166615.1
Wwp2
WW domain containing E3 ubiquitin protein ligase 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.9 24.7 GO:0015671 oxygen transport(GO:0015671)
0.6 2.2 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.5 1.5 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.5 1.9 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.5 1.9 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.5 1.4 GO:0060382 regulation of DNA strand elongation(GO:0060382)
0.4 1.2 GO:0007341 penetration of zona pellucida(GO:0007341)
0.4 1.1 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.3 2.4 GO:0051461 protein import into peroxisome matrix, docking(GO:0016560) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.3 1.2 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.2 0.7 GO:0046462 monoacylglycerol metabolic process(GO:0046462)
0.2 1.2 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.2 1.1 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.2 1.0 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.2 2.1 GO:0002693 positive regulation of cellular extravasation(GO:0002693)
0.1 0.6 GO:0055071 cellular manganese ion homeostasis(GO:0030026) Golgi calcium ion homeostasis(GO:0032468) manganese ion homeostasis(GO:0055071)
0.1 1.5 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 0.5 GO:0010756 positive regulation of plasminogen activation(GO:0010756)
0.1 0.9 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.1 2.2 GO:0046069 cGMP catabolic process(GO:0046069)
0.1 1.0 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.1 0.6 GO:0000189 MAPK import into nucleus(GO:0000189)
0.1 0.3 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.1 1.9 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.1 0.7 GO:1990416 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.1 0.4 GO:0072592 regulation of integrin biosynthetic process(GO:0045113) oxygen metabolic process(GO:0072592)
0.1 0.6 GO:0032782 bile acid secretion(GO:0032782) positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.1 0.5 GO:0045218 zonula adherens maintenance(GO:0045218)
0.1 3.6 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 0.7 GO:0046085 adenosine metabolic process(GO:0046085)
0.1 0.9 GO:0046485 ether lipid metabolic process(GO:0046485)
0.1 0.4 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.1 0.2 GO:1904742 regulation of telomeric DNA binding(GO:1904742)
0.1 0.2 GO:0035964 COPI-coated vesicle budding(GO:0035964)
0.1 0.6 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 1.2 GO:0042832 defense response to protozoan(GO:0042832)
0.1 0.5 GO:0034242 negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
0.1 0.2 GO:0071726 response to diacyl bacterial lipopeptide(GO:0071724) cellular response to diacyl bacterial lipopeptide(GO:0071726)
0.0 0.4 GO:0042167 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.0 0.9 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.7 GO:0007202 activation of phospholipase C activity(GO:0007202) positive regulation of execution phase of apoptosis(GO:1900119)
0.0 0.2 GO:1901252 regulation of intracellular transport of viral material(GO:1901252)
0.0 0.3 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
0.0 0.2 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.0 0.5 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.0 2.2 GO:1902653 cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653)
0.0 0.5 GO:0034377 plasma lipoprotein particle assembly(GO:0034377)
0.0 2.9 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 1.0 GO:0010719 negative regulation of epithelial to mesenchymal transition(GO:0010719)
0.0 0.4 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.0 0.3 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 0.2 GO:0061032 visceral serous pericardium development(GO:0061032)
0.0 1.4 GO:0042982 amyloid precursor protein metabolic process(GO:0042982)
0.0 0.6 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 0.2 GO:0006451 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0 0.2 GO:0086023 adrenergic receptor signaling pathway involved in heart process(GO:0086023)
0.0 0.1 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0 0.2 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.0 0.6 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.5 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 0.7 GO:0015804 neutral amino acid transport(GO:0015804)
0.0 0.4 GO:0006353 DNA-templated transcription, termination(GO:0006353)
0.0 0.2 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 0.3 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.1 GO:0030828 positive regulation of cGMP biosynthetic process(GO:0030828)
0.0 0.1 GO:0046549 retinal cone cell development(GO:0046549)
0.0 1.3 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.3 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.1 GO:0018242 protein O-linked glycosylation via serine(GO:0018242)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 24.7 GO:0005833 hemoglobin complex(GO:0005833)
0.6 2.4 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.3 0.9 GO:0005584 collagen type I trimer(GO:0005584)
0.2 1.0 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.2 1.4 GO:0070187 telosome(GO:0070187)
0.2 1.7 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.2 0.6 GO:1990075 kinesin II complex(GO:0016939) periciliary membrane compartment(GO:1990075)
0.2 2.2 GO:0038037 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
0.2 0.8 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.1 1.9 GO:0071437 invadopodium(GO:0071437)
0.1 1.5 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.1 0.5 GO:0036449 microtubule minus-end(GO:0036449)
0.1 0.5 GO:0070847 core mediator complex(GO:0070847)
0.1 0.6 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 1.1 GO:0045180 basal cortex(GO:0045180)
0.1 0.4 GO:1990393 3M complex(GO:1990393)
0.1 0.8 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
0.1 0.3 GO:1990111 spermatoproteasome complex(GO:1990111)
0.1 1.0 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 0.6 GO:0031143 pseudopodium(GO:0031143)
0.1 0.5 GO:0008290 F-actin capping protein complex(GO:0008290)
0.1 0.7 GO:0031209 SCAR complex(GO:0031209)
0.0 0.2 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 0.9 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 0.3 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.4 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.2 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.0 0.3 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 0.3 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.6 GO:0005811 lipid particle(GO:0005811)
0.0 0.4 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 1.2 GO:0005798 Golgi-associated vesicle(GO:0005798)
0.0 0.2 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.3 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 1.6 GO:0030496 midbody(GO:0030496)
0.0 0.1 GO:0033588 Elongator holoenzyme complex(GO:0033588)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.9 24.7 GO:0005344 oxygen transporter activity(GO:0005344)
0.6 2.2 GO:0001639 PLC activating G-protein coupled glutamate receptor activity(GO:0001639) G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.5 2.4 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.5 1.4 GO:1990955 G-rich single-stranded DNA binding(GO:1990955)
0.4 1.2 GO:0004743 pyruvate kinase activity(GO:0004743)
0.4 1.9 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.3 2.2 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.3 0.8 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.2 0.6 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.2 1.0 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.2 1.6 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.2 0.5 GO:0003846 2-acylglycerol O-acyltransferase activity(GO:0003846)
0.2 0.9 GO:0016803 ether hydrolase activity(GO:0016803)
0.2 0.6 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.1 0.6 GO:0015410 manganese-transporting ATPase activity(GO:0015410)
0.1 0.4 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.1 0.3 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.1 0.6 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.1 0.4 GO:0004074 biliverdin reductase activity(GO:0004074)
0.1 0.5 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.1 1.0 GO:0070097 delta-catenin binding(GO:0070097)
0.1 1.2 GO:0005537 mannose binding(GO:0005537)
0.1 0.2 GO:0071723 lipopeptide binding(GO:0071723)
0.1 0.9 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 1.5 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 0.5 GO:0051011 microtubule minus-end binding(GO:0051011)
0.1 0.9 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.0 3.2 GO:0005518 collagen binding(GO:0005518)
0.0 0.7 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.1 GO:0051525 NFAT protein binding(GO:0051525)
0.0 0.7 GO:0017166 vinculin binding(GO:0017166)
0.0 0.2 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 0.1 GO:0030249 guanylate cyclase regulator activity(GO:0030249)
0.0 0.2 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.0 1.7 GO:0070888 E-box binding(GO:0070888)
0.0 0.2 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.6 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.1 GO:0008502 melatonin receptor activity(GO:0008502)
0.0 0.2 GO:0070513 death domain binding(GO:0070513)
0.0 0.4 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 0.1 GO:0070728 leucine binding(GO:0070728)
0.0 0.8 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin binding(GO:0030332)
0.0 0.7 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 0.5 GO:0050699 WW domain binding(GO:0050699)
0.0 0.2 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.7 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.4 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.0 0.2 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.0 0.3 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.1 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.1 0.7 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 1.7 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.9 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 1.2 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.0 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 0.3 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.0 0.9 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.5 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.7 PID_RHOA_REG_PATHWAY Regulation of RhoA activity

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.9 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.2 3.0 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.2 1.7 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.2 2.2 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 1.5 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.1 3.3 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 0.3 REACTOME_PD1_SIGNALING Genes involved in PD-1 signaling
0.1 2.2 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 0.7 REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM Genes involved in Abacavir transport and metabolism
0.0 1.2 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.7 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.6 REACTOME_RAF_MAP_KINASE_CASCADE Genes involved in RAF/MAP kinase cascade
0.0 1.6 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.6 REACTOME_KINESINS Genes involved in Kinesins
0.0 0.3 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.2 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.5 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.0 0.7 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 1.2 REACTOME_REGULATION_OF_APOPTOSIS Genes involved in Regulation of Apoptosis
0.0 0.4 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.4 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.3 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.2 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 0.5 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.2 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.3 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation