Motif ID: Klf3

Z-value: 0.326


Transcription factors associated with Klf3:

Gene SymbolEntrez IDGene Name
Klf3 ENSMUSG00000029178.8 Klf3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf3mm10_v2_chr5_+_64812336_64812350-0.579.1e-05Click!


Activity profile for motif Klf3.

activity profile for motif Klf3


Sorted Z-values histogram for motif Klf3

Sorted Z-values for motif Klf3



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_107511489 1.354 ENSMUST00000064916.2
Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr1_+_107511416 1.291 ENSMUST00000009356.4
Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr1_+_72824482 1.231 ENSMUST00000047328.4
Igfbp2
insulin-like growth factor binding protein 2
chr7_+_82337218 0.953 ENSMUST00000173828.1
Adamtsl3
ADAMTS-like 3
chrX_-_102252154 0.762 ENSMUST00000050551.3
Cited1
Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1
chrX_-_102251852 0.698 ENSMUST00000101336.3
ENSMUST00000136277.1
Cited1

Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1

chr3_+_135438722 0.695 ENSMUST00000166033.1
Ube2d3
ubiquitin-conjugating enzyme E2D 3
chr11_+_68968107 0.412 ENSMUST00000102606.3
ENSMUST00000018884.5
Slc25a35

solute carrier family 25, member 35

chr1_+_131867224 0.319 ENSMUST00000112386.1
ENSMUST00000027693.7
Rab7l1

RAB7, member RAS oncogene family-like 1

chr3_+_90080442 0.313 ENSMUST00000127955.1
Tpm3
tropomyosin 3, gamma
chr12_+_87026286 0.308 ENSMUST00000146292.1
Tmem63c
transmembrane protein 63c
chr3_+_90079540 0.306 ENSMUST00000029549.9
ENSMUST00000118566.1
ENSMUST00000119158.1
Tpm3


tropomyosin 3, gamma


chr12_+_87026564 0.295 ENSMUST00000110187.1
ENSMUST00000156162.1
Tmem63c

transmembrane protein 63c

chr1_+_86064619 0.238 ENSMUST00000027432.8
Psmd1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr5_+_124541296 0.236 ENSMUST00000124529.1
Tmed2
transmembrane emp24 domain trafficking protein 2
chr19_+_10041548 0.175 ENSMUST00000115995.2
Fads3
fatty acid desaturase 3
chr9_-_67539392 0.162 ENSMUST00000039662.8
Tln2
talin 2
chr9_-_108305941 0.152 ENSMUST00000044725.7
Tcta
T cell leukemia translocation altered gene
chr19_-_53390559 0.115 ENSMUST00000025997.5
Smndc1
survival motor neuron domain containing 1
chr13_-_74292297 0.114 ENSMUST00000109640.1
ENSMUST00000022059.7
Ahrr

aryl-hydrocarbon receptor repressor

chr3_+_89266552 0.109 ENSMUST00000040824.1
Dpm3
dolichyl-phosphate mannosyltransferase polypeptide 3
chr11_+_99041237 0.093 ENSMUST00000017637.6
Igfbp4
insulin-like growth factor binding protein 4
chr5_+_137630116 0.072 ENSMUST00000175968.1
Lrch4
leucine-rich repeats and calponin homology (CH) domain containing 4
chr7_-_17027853 0.064 ENSMUST00000003183.5
Ppp5c
protein phosphatase 5, catalytic subunit
chr7_-_4149781 0.060 ENSMUST00000058358.6
Leng9
leukocyte receptor cluster (LRC) member 9
chr7_-_17027807 0.060 ENSMUST00000142597.1
Ppp5c
protein phosphatase 5, catalytic subunit
chrX_+_7884321 0.044 ENSMUST00000096514.3
ENSMUST00000123277.1
Slc35a2

solute carrier family 35 (UDP-galactose transporter), member A2

chr11_+_75679542 0.024 ENSMUST00000147718.1
Crk
v-crk sarcoma virus CT10 oncogene homolog (avian)
chrX_-_74246534 0.024 ENSMUST00000101454.2
ENSMUST00000033699.6
Flna

filamin, alpha


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.5 GO:0071105 response to interleukin-9(GO:0071104) response to interleukin-11(GO:0071105)
0.1 1.3 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0 0.2 GO:0072675 osteoclast fusion(GO:0072675)
0.0 0.7 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.2 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 0.2 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
0.0 0.1 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 2.6 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.0 0.1 GO:0035269 protein O-linked mannosylation(GO:0035269)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.1 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.0 0.2 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.2 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540) cytosolic proteasome complex(GO:0031597)
0.0 0.2 GO:0005916 fascia adherens(GO:0005916)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 1.5 GO:0050693 LBD domain binding(GO:0050693)
0.1 2.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.1 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.0 0.6 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.0 0.6 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.7 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.0 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 3.6 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.7 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 1.5 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.7 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.6 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.2 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi