Motif ID: Rhox4e_Rhox6_Vax2
Z-value: 1.084



Transcription factors associated with Rhox4e_Rhox6_Vax2:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Rhox4e | ENSMUSG00000071770.4 | Rhox4e |
Rhox6 | ENSMUSG00000006200.3 | Rhox6 |
Vax2 | ENSMUSG00000034777.1 | Vax2 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Vax2 | mm10_v2_chr6_+_83711232_83711288 | -0.24 | 1.4e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
3.9 | 23.3 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
1.0 | 4.8 | GO:0072235 | distal convoluted tubule development(GO:0072025) metanephric distal convoluted tubule development(GO:0072221) metanephric distal tubule development(GO:0072235) |
0.7 | 4.6 | GO:0021555 | midbrain-hindbrain boundary morphogenesis(GO:0021555) |
0.6 | 1.8 | GO:1902498 | regulation of protein autoubiquitination(GO:1902498) |
0.4 | 1.3 | GO:0035880 | embryonic nail plate morphogenesis(GO:0035880) positive regulation of catagen(GO:0051795) frontal suture morphogenesis(GO:0060364) |
0.4 | 0.8 | GO:0061738 | late endosomal microautophagy(GO:0061738) |
0.4 | 8.4 | GO:0007530 | sex determination(GO:0007530) |
0.4 | 3.8 | GO:0036376 | sodium ion export from cell(GO:0036376) |
0.3 | 1.0 | GO:0016554 | cytidine to uridine editing(GO:0016554) |
0.3 | 3.0 | GO:0016198 | axon choice point recognition(GO:0016198) |
0.3 | 14.8 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
0.3 | 2.0 | GO:0098535 | positive regulation of centriole replication(GO:0046601) de novo centriole assembly(GO:0098535) |
0.2 | 0.7 | GO:0060478 | acrosomal vesicle exocytosis(GO:0060478) |
0.2 | 3.9 | GO:0001833 | inner cell mass cell proliferation(GO:0001833) |
0.2 | 0.6 | GO:2000393 | negative regulation of lamellipodium morphogenesis(GO:2000393) |
0.2 | 1.1 | GO:0070562 | regulation of vitamin D receptor signaling pathway(GO:0070562) |
0.2 | 0.5 | GO:0060489 | orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490) |
0.2 | 1.2 | GO:0002862 | negative regulation of inflammatory response to antigenic stimulus(GO:0002862) protein oxidation(GO:0018158) |
0.2 | 0.6 | GO:0006742 | NADP catabolic process(GO:0006742) pyridine nucleotide catabolic process(GO:0019364) |
0.1 | 0.6 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
0.1 | 1.0 | GO:1902035 | positive regulation of hematopoietic stem cell proliferation(GO:1902035) |
0.1 | 1.1 | GO:0006003 | fructose 2,6-bisphosphate metabolic process(GO:0006003) |
0.1 | 0.7 | GO:1901837 | negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837) |
0.1 | 2.8 | GO:0010172 | embryonic body morphogenesis(GO:0010172) |
0.1 | 1.9 | GO:0003334 | keratinocyte development(GO:0003334) |
0.1 | 4.6 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
0.1 | 2.6 | GO:0008340 | determination of adult lifespan(GO:0008340) |
0.1 | 0.7 | GO:0070317 | negative regulation of G0 to G1 transition(GO:0070317) |
0.1 | 0.3 | GO:0070543 | response to linoleic acid(GO:0070543) |
0.1 | 0.4 | GO:0090168 | Golgi reassembly(GO:0090168) |
0.1 | 0.4 | GO:0009235 | cobalamin metabolic process(GO:0009235) |
0.1 | 2.2 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
0.1 | 3.0 | GO:0035329 | hippo signaling(GO:0035329) |
0.1 | 2.5 | GO:0050873 | brown fat cell differentiation(GO:0050873) |
0.1 | 0.3 | GO:1903377 | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377) |
0.1 | 0.4 | GO:0046689 | response to mercury ion(GO:0046689) |
0.1 | 0.5 | GO:0000395 | mRNA 5'-splice site recognition(GO:0000395) |
0.1 | 0.8 | GO:2000042 | negative regulation of double-strand break repair via homologous recombination(GO:2000042) |
0.0 | 1.5 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
0.0 | 0.6 | GO:0045899 | positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899) |
0.0 | 1.0 | GO:0051560 | mitochondrial calcium ion homeostasis(GO:0051560) |
0.0 | 0.2 | GO:0015819 | lysine transport(GO:0015819) ornithine transport(GO:0015822) |
0.0 | 0.4 | GO:0042572 | retinol metabolic process(GO:0042572) |
0.0 | 0.3 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
0.0 | 0.9 | GO:0006907 | pinocytosis(GO:0006907) |
0.0 | 2.6 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
0.0 | 0.4 | GO:0061436 | establishment of skin barrier(GO:0061436) |
0.0 | 2.4 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
0.0 | 0.5 | GO:0006337 | nucleosome disassembly(GO:0006337) |
0.0 | 0.4 | GO:0006107 | oxaloacetate metabolic process(GO:0006107) |
0.0 | 0.5 | GO:0006622 | protein targeting to lysosome(GO:0006622) |
0.0 | 0.2 | GO:0061732 | mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732) |
0.0 | 0.6 | GO:0033194 | response to hydroperoxide(GO:0033194) |
0.0 | 0.1 | GO:0031034 | myosin filament assembly(GO:0031034) striated muscle myosin thick filament assembly(GO:0071688) |
0.0 | 0.1 | GO:0090063 | positive regulation of microtubule nucleation(GO:0090063) |
0.0 | 1.6 | GO:0022904 | respiratory electron transport chain(GO:0022904) |
0.0 | 8.3 | GO:0018105 | peptidyl-serine phosphorylation(GO:0018105) |
0.0 | 1.5 | GO:0016126 | sterol biosynthetic process(GO:0016126) |
0.0 | 0.3 | GO:0001675 | acrosome assembly(GO:0001675) |
0.0 | 0.6 | GO:0043171 | peptide catabolic process(GO:0043171) |
0.0 | 0.3 | GO:2000353 | positive regulation of endothelial cell apoptotic process(GO:2000353) |
0.0 | 0.6 | GO:0051693 | actin filament capping(GO:0051693) |
0.0 | 2.4 | GO:0000910 | cytokinesis(GO:0000910) |
0.0 | 0.2 | GO:0090036 | regulation of protein kinase C signaling(GO:0090036) |
0.0 | 0.0 | GO:0031392 | regulation of prostaglandin biosynthetic process(GO:0031392) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) |
0.0 | 0.2 | GO:0051900 | regulation of mitochondrial depolarization(GO:0051900) |
0.0 | 0.6 | GO:0034605 | cellular response to heat(GO:0034605) |
0.0 | 1.6 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
0.0 | 0.2 | GO:0006474 | N-terminal protein amino acid acetylation(GO:0006474) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 3.8 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
0.4 | 1.1 | GO:0043540 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540) |
0.3 | 2.0 | GO:0098536 | deuterosome(GO:0098536) |
0.2 | 2.2 | GO:0072669 | tRNA-splicing ligase complex(GO:0072669) |
0.2 | 1.4 | GO:0031313 | extrinsic component of endosome membrane(GO:0031313) |
0.2 | 1.1 | GO:0005726 | perichromatin fibrils(GO:0005726) |
0.2 | 2.2 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
0.2 | 1.2 | GO:0097413 | Lewy body(GO:0097413) |
0.1 | 3.0 | GO:0031527 | filopodium membrane(GO:0031527) |
0.1 | 0.5 | GO:0060187 | cell pole(GO:0060187) |
0.1 | 0.7 | GO:0001740 | Barr body(GO:0001740) |
0.1 | 0.7 | GO:0090543 | Flemming body(GO:0090543) |
0.1 | 1.0 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
0.1 | 0.2 | GO:0031417 | NatC complex(GO:0031417) |
0.1 | 0.7 | GO:0000812 | Swr1 complex(GO:0000812) |
0.1 | 0.6 | GO:0031595 | nuclear proteasome complex(GO:0031595) |
0.1 | 0.4 | GO:0034709 | methylosome(GO:0034709) |
0.0 | 0.3 | GO:0033503 | HULC complex(GO:0033503) |
0.0 | 4.8 | GO:0043195 | terminal bouton(GO:0043195) |
0.0 | 1.0 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
0.0 | 2.0 | GO:0043034 | costamere(GO:0043034) |
0.0 | 0.5 | GO:0000243 | commitment complex(GO:0000243) |
0.0 | 1.9 | GO:0002102 | podosome(GO:0002102) |
0.0 | 15.9 | GO:0014069 | postsynaptic density(GO:0014069) |
0.0 | 0.5 | GO:0005640 | nuclear outer membrane(GO:0005640) |
0.0 | 0.3 | GO:0042382 | paraspeckles(GO:0042382) |
0.0 | 3.9 | GO:0000792 | heterochromatin(GO:0000792) |
0.0 | 2.0 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
0.0 | 0.5 | GO:0071564 | npBAF complex(GO:0071564) |
0.0 | 3.4 | GO:0005923 | bicellular tight junction(GO:0005923) |
0.0 | 0.2 | GO:0045254 | pyruvate dehydrogenase complex(GO:0045254) |
0.0 | 0.8 | GO:0035861 | site of double-strand break(GO:0035861) |
0.0 | 0.1 | GO:0005859 | muscle myosin complex(GO:0005859) |
0.0 | 0.9 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
0.0 | 0.1 | GO:0045275 | respiratory chain complex III(GO:0045275) |
0.0 | 0.1 | GO:0030689 | Noc complex(GO:0030689) |
0.0 | 0.8 | GO:0000786 | nucleosome(GO:0000786) |
0.0 | 0.1 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
0.0 | 2.0 | GO:0070382 | exocytic vesicle(GO:0070382) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.2 | 4.6 | GO:0003836 | beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836) |
0.4 | 3.0 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) |
0.4 | 3.8 | GO:0008556 | sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556) |
0.3 | 1.0 | GO:0004126 | cytidine deaminase activity(GO:0004126) |
0.2 | 8.2 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
0.2 | 1.1 | GO:0034056 | estrogen response element binding(GO:0034056) |
0.2 | 1.1 | GO:0070095 | fructose-6-phosphate binding(GO:0070095) |
0.2 | 0.6 | GO:0035529 | NADH pyrophosphatase activity(GO:0035529) |
0.1 | 0.6 | GO:0015183 | L-aspartate transmembrane transporter activity(GO:0015183) |
0.1 | 0.9 | GO:0034452 | dynactin binding(GO:0034452) |
0.1 | 0.8 | GO:0061649 | ubiquitinated histone binding(GO:0061649) |
0.1 | 23.3 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
0.1 | 0.4 | GO:0004321 | fatty-acyl-CoA synthase activity(GO:0004321) |
0.1 | 2.1 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
0.1 | 0.3 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
0.1 | 0.6 | GO:0036402 | proteasome-activating ATPase activity(GO:0036402) |
0.1 | 4.6 | GO:0098811 | transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811) |
0.1 | 0.4 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
0.1 | 1.6 | GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) |
0.1 | 0.2 | GO:0015254 | glycerol channel activity(GO:0015254) |
0.1 | 4.6 | GO:0019842 | vitamin binding(GO:0019842) |
0.1 | 0.5 | GO:1990446 | U1 snRNP binding(GO:1990446) |
0.1 | 0.6 | GO:0050897 | cobalt ion binding(GO:0050897) |
0.1 | 1.8 | GO:0031435 | mitogen-activated protein kinase kinase kinase binding(GO:0031435) |
0.1 | 1.2 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
0.0 | 2.2 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
0.0 | 0.1 | GO:0031686 | A1 adenosine receptor binding(GO:0031686) |
0.0 | 0.2 | GO:0000064 | L-ornithine transmembrane transporter activity(GO:0000064) |
0.0 | 0.3 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
0.0 | 0.5 | GO:0043495 | protein anchor(GO:0043495) |
0.0 | 2.3 | GO:0015078 | hydrogen ion transmembrane transporter activity(GO:0015078) |
0.0 | 0.1 | GO:0031727 | CCR2 chemokine receptor binding(GO:0031727) |
0.0 | 0.2 | GO:0034604 | pyruvate dehydrogenase activity(GO:0004738) oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604) |
0.0 | 7.3 | GO:0000287 | magnesium ion binding(GO:0000287) |
0.0 | 0.4 | GO:0002161 | aminoacyl-tRNA editing activity(GO:0002161) |
0.0 | 3.4 | GO:0016779 | nucleotidyltransferase activity(GO:0016779) |
0.0 | 0.1 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
0.0 | 0.1 | GO:0052740 | phosphatidylserine 1-acylhydrolase activity(GO:0052739) 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740) |
0.0 | 0.4 | GO:0008327 | methyl-CpG binding(GO:0008327) |
0.0 | 1.2 | GO:0031491 | nucleosome binding(GO:0031491) |
0.0 | 0.2 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
0.0 | 1.6 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
0.0 | 3.3 | GO:0003924 | GTPase activity(GO:0003924) |
0.0 | 11.2 | GO:0019904 | protein domain specific binding(GO:0019904) |
0.0 | 0.3 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
0.0 | 1.7 | GO:0051015 | actin filament binding(GO:0051015) |
0.0 | 0.1 | GO:0035368 | selenocysteine insertion sequence binding(GO:0035368) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 3.1 | PID_NCADHERIN_PATHWAY | N-cadherin signaling events |
0.1 | 2.4 | PID_AURORA_B_PATHWAY | Aurora B signaling |
0.0 | 0.5 | PID_ERB_GENOMIC_PATHWAY | Validated nuclear estrogen receptor beta network |
0.0 | 3.4 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
0.0 | 2.0 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
0.0 | 1.1 | PID_AR_TF_PATHWAY | Regulation of Androgen receptor activity |
0.0 | 0.3 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
0.0 | 1.5 | PID_P53_DOWNSTREAM_PATHWAY | Direct p53 effectors |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 4.6 | REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
0.1 | 1.2 | REACTOME_PURINE_CATABOLISM | Genes involved in Purine catabolism |
0.1 | 3.8 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
0.1 | 3.0 | REACTOME_SIGNALING_BY_HIPPO | Genes involved in Signaling by Hippo |
0.1 | 2.4 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
0.1 | 1.6 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
0.0 | 1.7 | REACTOME_GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
0.0 | 1.1 | REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
0.0 | 0.2 | REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
0.0 | 0.7 | REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
0.0 | 1.8 | REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
0.0 | 1.0 | REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
0.0 | 0.4 | REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
0.0 | 0.2 | REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
0.0 | 0.4 | REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
0.0 | 1.0 | REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
0.0 | 0.4 | REACTOME_RAP1_SIGNALLING | Genes involved in Rap1 signalling |
0.0 | 0.2 | REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
0.0 | 0.3 | REACTOME_SULFUR_AMINO_ACID_METABOLISM | Genes involved in Sulfur amino acid metabolism |
0.0 | 3.0 | REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
0.0 | 0.3 | REACTOME_ANTIGEN_PROCESSING_CROSS_PRESENTATION | Genes involved in Antigen processing-Cross presentation |
0.0 | 0.4 | REACTOME_CELL_CELL_JUNCTION_ORGANIZATION | Genes involved in Cell-cell junction organization |
0.0 | 0.3 | REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA | Genes involved in G beta:gamma signalling through PLC beta |