Motif ID: Tbx1_Eomes

Z-value: 0.914

Transcription factors associated with Tbx1_Eomes:

Gene SymbolEntrez IDGene Name
Eomes ENSMUSG00000032446.8 Eomes
Tbx1 ENSMUSG00000009097.9 Tbx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Eomesmm10_v2_chr9_+_118478182_118478212-0.305.6e-02Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx1_Eomes

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_26229707 19.624 ENSMUST00000060716.5
ENSMUST00000164660.1
Samd3

sterile alpha motif domain containing 3

chr2_-_13011747 11.966 ENSMUST00000061545.5
C1ql3
C1q-like 3
chr1_+_6730051 10.175 ENSMUST00000043578.6
ENSMUST00000131467.1
ENSMUST00000150761.1
ENSMUST00000151281.1
St18



suppression of tumorigenicity 18



chr4_+_125490688 9.593 ENSMUST00000030676.7
Grik3
glutamate receptor, ionotropic, kainate 3
chr1_-_138847579 9.254 ENSMUST00000093486.3
ENSMUST00000046870.6
Lhx9

LIM homeobox protein 9

chr2_-_57114970 7.911 ENSMUST00000028166.2
Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr9_-_43239816 7.543 ENSMUST00000034512.5
Oaf
OAF homolog (Drosophila)
chr1_+_6730135 6.596 ENSMUST00000155921.1
St18
suppression of tumorigenicity 18
chr17_+_29093763 6.283 ENSMUST00000023829.6
Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr2_+_164562579 6.172 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
Wfdc2


WAP four-disulfide core domain 2


chr6_-_94700137 5.784 ENSMUST00000101126.2
ENSMUST00000032105.4
Lrig1

leucine-rich repeats and immunoglobulin-like domains 1

chr7_-_28302238 5.031 ENSMUST00000108315.3
Dll3
delta-like 3 (Drosophila)
chr1_+_132316112 4.893 ENSMUST00000082125.5
ENSMUST00000072177.7
Nuak2

NUAK family, SNF1-like kinase, 2

chr4_-_35845204 4.886 ENSMUST00000164772.1
ENSMUST00000065173.2
Lingo2

leucine rich repeat and Ig domain containing 2

chr12_+_3891728 4.660 ENSMUST00000172689.1
ENSMUST00000111186.1
Dnmt3a

DNA methyltransferase 3A

chr6_+_7555053 3.981 ENSMUST00000090679.2
ENSMUST00000184986.1
Tac1

tachykinin 1

chr10_-_92162753 3.839 ENSMUST00000182197.1
Rmst
rhabdomyosarcoma 2 associated transcript (non-coding RNA)
chr10_-_120899067 3.797 ENSMUST00000092143.5
Msrb3
methionine sulfoxide reductase B3
chr6_+_15196949 3.756 ENSMUST00000151301.1
ENSMUST00000131414.1
ENSMUST00000140557.1
ENSMUST00000115469.1
Foxp2



forkhead box P2



chrX_+_142681398 3.746 ENSMUST00000112889.1
ENSMUST00000101198.2
ENSMUST00000112891.1
ENSMUST00000087333.2
Tmem164



transmembrane protein 164



chr1_+_153665274 3.514 ENSMUST00000152114.1
ENSMUST00000111812.1
Rgs8

regulator of G-protein signaling 8

chr10_+_4710119 3.218 ENSMUST00000105588.1
ENSMUST00000105589.1
Esr1

estrogen receptor 1 (alpha)

chr18_-_46212595 3.127 ENSMUST00000037011.4
Trim36
tripartite motif-containing 36
chr1_+_153665666 3.060 ENSMUST00000111814.1
ENSMUST00000111810.1
Rgs8

regulator of G-protein signaling 8

chr10_+_56377300 2.859 ENSMUST00000068581.7
Gja1
gap junction protein, alpha 1
chrX_+_100729917 2.859 ENSMUST00000019503.7
Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chr4_-_134018829 2.858 ENSMUST00000051674.2
Lin28a
lin-28 homolog A (C. elegans)
chr18_+_60963517 2.788 ENSMUST00000115295.2
ENSMUST00000039904.6
Camk2a

calcium/calmodulin-dependent protein kinase II alpha

chr7_-_141443989 2.507 ENSMUST00000026580.5
Lrdd
leucine-rich and death domain containing
chr1_+_153665587 2.476 ENSMUST00000147700.1
Rgs8
regulator of G-protein signaling 8
chrX_+_100730178 2.407 ENSMUST00000113744.1
Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chr17_-_70849644 2.406 ENSMUST00000134654.1
ENSMUST00000172229.1
ENSMUST00000127719.1
Tgif1


TGFB-induced factor homeobox 1


chr1_+_153665627 2.397 ENSMUST00000147482.1
Rgs8
regulator of G-protein signaling 8
chr11_-_94507337 2.024 ENSMUST00000040692.8
Mycbpap
MYCBP associated protein
chr8_+_106870827 1.975 ENSMUST00000176144.1
ENSMUST00000175987.1
Has3

hyaluronan synthase 3

chr19_+_20601958 1.794 ENSMUST00000087638.3
Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
chr4_+_117849361 1.735 ENSMUST00000163288.1
Slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr1_+_131970589 1.699 ENSMUST00000027695.6
Slc45a3
solute carrier family 45, member 3
chr3_+_96629919 1.699 ENSMUST00000048915.6
Rbm8a
RNA binding motif protein 8a
chr2_+_20519776 1.600 ENSMUST00000114604.2
ENSMUST00000066509.3
Etl4

enhancer trap locus 4

chr9_-_69760924 1.577 ENSMUST00000071281.4
Foxb1
forkhead box B1
chr4_-_132510493 1.574 ENSMUST00000030724.8
Sesn2
sestrin 2
chr5_+_115908644 1.427 ENSMUST00000141101.1
Cit
citron
chr9_-_95845215 1.389 ENSMUST00000093800.2
Pls1
plastin 1 (I-isoform)
chr3_+_40950631 1.358 ENSMUST00000048490.6
Larp1b
La ribonucleoprotein domain family, member 1B
chrX_-_53269020 1.343 ENSMUST00000114838.1
Fam122b
family with sequence similarity 122, member B
chr14_+_62292475 1.330 ENSMUST00000166879.1
Rnaseh2b
ribonuclease H2, subunit B
chr1_+_164115264 1.222 ENSMUST00000162746.1
Selp
selectin, platelet
chr2_+_27079371 1.199 ENSMUST00000091233.6
Adamtsl2
ADAMTS-like 2
chr17_+_48932368 1.177 ENSMUST00000046254.2
Lrfn2
leucine rich repeat and fibronectin type III domain containing 2
chr4_-_123750236 1.174 ENSMUST00000102636.3
Akirin1
akirin 1
chr3_-_154328634 1.142 ENSMUST00000167744.1
Lhx8
LIM homeobox protein 8
chr5_-_24329556 1.136 ENSMUST00000115098.2
Kcnh2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chrX_-_152016269 1.089 ENSMUST00000026288.4
Ribc1
RIB43A domain with coiled-coils 1
chr1_-_69108039 1.087 ENSMUST00000121473.1
Erbb4
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
chr6_+_50110837 1.080 ENSMUST00000167628.1
Mpp6
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
chr9_+_35421541 1.037 ENSMUST00000119129.2
Cdon
cell adhesion molecule-related/down-regulated by oncogenes
chr2_-_148046896 1.005 ENSMUST00000172928.1
ENSMUST00000047315.3
Foxa2

forkhead box A2

chr1_-_174921813 0.917 ENSMUST00000055294.3
Grem2
gremlin 2 homolog, cysteine knot superfamily (Xenopus laevis)
chr10_-_128211788 0.881 ENSMUST00000061995.8
Spryd4
SPRY domain containing 4
chr16_-_9994921 0.880 ENSMUST00000115835.1
Grin2a
glutamate receptor, ionotropic, NMDA2A (epsilon 1)
chr15_-_98831498 0.868 ENSMUST00000168846.1
Prkag1
protein kinase, AMP-activated, gamma 1 non-catalytic subunit
chr13_-_43304153 0.864 ENSMUST00000055341.5
Gfod1
glucose-fructose oxidoreductase domain containing 1
chr10_-_85916902 0.848 ENSMUST00000037646.7
Prdm4
PR domain containing 4
chr11_+_98348404 0.828 ENSMUST00000078694.6
Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr13_-_89742490 0.821 ENSMUST00000109546.2
Vcan
versican
chr16_-_56024628 0.799 ENSMUST00000119981.1
ENSMUST00000096021.3
Pcnp

PEST proteolytic signal containing nuclear protein

chrM_+_8600 0.796 ENSMUST00000082409.1
mt-Co3
mitochondrially encoded cytochrome c oxidase III
chr2_-_25272380 0.794 ENSMUST00000028342.6
Ssna1
Sjogren's syndrome nuclear autoantigen 1
chr7_-_115824699 0.785 ENSMUST00000169129.1
Sox6
SRY-box containing gene 6
chr10_+_80930071 0.780 ENSMUST00000015456.8
Gadd45b
growth arrest and DNA-damage-inducible 45 beta
chr10_-_35711891 0.779 ENSMUST00000080898.2
Amd2
S-adenosylmethionine decarboxylase 2
chr4_+_117849193 0.779 ENSMUST00000132043.2
ENSMUST00000169990.1
Slc6a9

solute carrier family 6 (neurotransmitter transporter, glycine), member 9

chrM_+_9452 0.751 ENSMUST00000082411.1
mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chr9_+_15239045 0.743 ENSMUST00000034413.6
Vstm5
V-set and transmembrane domain containing 5
chr3_-_10208569 0.723 ENSMUST00000029041.4
Fabp4
fatty acid binding protein 4, adipocyte
chr6_-_24956106 0.713 ENSMUST00000127247.2
Tmem229a
transmembrane protein 229A
chr19_+_6057925 0.712 ENSMUST00000179142.1
Fau
Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived)
chr7_-_114117761 0.705 ENSMUST00000069449.5
Rras2
related RAS viral (r-ras) oncogene homolog 2
chr3_+_102734496 0.702 ENSMUST00000029451.5
Tspan2
tetraspanin 2
chr1_+_74236479 0.701 ENSMUST00000113820.2
ENSMUST00000006467.7
ENSMUST00000113819.1
Arpc2


actin related protein 2/3 complex, subunit 2


chr1_+_170214826 0.697 ENSMUST00000159201.1
ENSMUST00000055830.1
4930500M09Rik

RIKEN cDNA 4930500M09 gene

chr2_+_138278481 0.688 ENSMUST00000075410.4
Btbd3
BTB (POZ) domain containing 3
chr6_-_21851914 0.648 ENSMUST00000134635.1
ENSMUST00000123116.1
ENSMUST00000120965.1
Tspan12


tetraspanin 12


chr4_-_117156144 0.634 ENSMUST00000102696.4
Rps8
ribosomal protein S8
chr19_+_6057888 0.616 ENSMUST00000043074.5
ENSMUST00000178310.1
Fau

Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived)

chr7_-_30563184 0.600 ENSMUST00000043898.6
Psenen
presenilin enhancer 2 homolog (C. elegans)
chr12_+_78861693 0.589 ENSMUST00000071230.7
Eif2s1
eukaryotic translation initiation factor 2, subunit 1 alpha
chr16_-_84835484 0.582 ENSMUST00000114191.1
Atp5j
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F
chr7_+_127746775 0.558 ENSMUST00000033081.7
Fbxl19
F-box and leucine-rich repeat protein 19
chr7_-_45830776 0.546 ENSMUST00000107723.2
ENSMUST00000131384.1
Grwd1

glutamate-rich WD repeat containing 1

chr12_+_55598917 0.540 ENSMUST00000051857.3
Insm2
insulinoma-associated 2
chr2_+_54436317 0.540 ENSMUST00000112636.1
ENSMUST00000112635.1
ENSMUST00000112634.1
Galnt13


UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13


chr13_+_93304066 0.510 ENSMUST00000109493.1
Homer1
homer homolog 1 (Drosophila)
chr11_-_22286795 0.501 ENSMUST00000109563.2
ENSMUST00000180360.1
Ehbp1

EH domain binding protein 1

chr19_+_4097392 0.498 ENSMUST00000174514.1
ENSMUST00000174149.1
Cdk2ap2

CDK2-associated protein 2

chr7_-_100658394 0.490 ENSMUST00000138830.1
ENSMUST00000107044.3
ENSMUST00000116287.2
Plekhb1


pleckstrin homology domain containing, family B (evectins) member 1


chr2_+_71528657 0.481 ENSMUST00000126400.1
Dlx1
distal-less homeobox 1
chr7_-_100658364 0.474 ENSMUST00000107043.1
Plekhb1
pleckstrin homology domain containing, family B (evectins) member 1
chr8_-_8639363 0.462 ENSMUST00000152698.1
Efnb2
ephrin B2
chr17_-_29237759 0.457 ENSMUST00000137727.1
ENSMUST00000024805.7
Cpne5

copine V

chr4_-_42168603 0.443 ENSMUST00000098121.3
Gm13305
predicted gene 13305
chr9_-_21073494 0.435 ENSMUST00000010348.5
Fdx1l
ferredoxin 1-like
chr3_+_51415986 0.430 ENSMUST00000029303.7
Naa15
N(alpha)-acetyltransferase 15, NatA auxiliary subunit
chrX_+_153006461 0.414 ENSMUST00000095755.3
Usp51
ubiquitin specific protease 51
chr2_-_30178422 0.409 ENSMUST00000100220.4
ENSMUST00000179795.1
D2Wsu81e

DNA segment, Chr 2, Wayne State University 81, expressed

chr15_+_10952332 0.407 ENSMUST00000022853.8
ENSMUST00000110523.1
C1qtnf3

C1q and tumor necrosis factor related protein 3

chr19_-_6057736 0.389 ENSMUST00000007482.6
Mrpl49
mitochondrial ribosomal protein L49
chr14_+_31251454 0.375 ENSMUST00000022458.4
Bap1
Brca1 associated protein 1
chr5_+_120513102 0.372 ENSMUST00000111889.1
Slc8b1
solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
chrM_+_7759 0.372 ENSMUST00000082407.1
ENSMUST00000082408.1
mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr15_+_74516196 0.371 ENSMUST00000042035.9
Bai1
brain-specific angiogenesis inhibitor 1
chr2_-_148045891 0.358 ENSMUST00000109964.1
Foxa2
forkhead box A2
chr9_-_13818665 0.334 ENSMUST00000150893.1
ENSMUST00000124883.1
Cep57

centrosomal protein 57

chr11_-_69681903 0.326 ENSMUST00000066760.1
Senp3
SUMO/sentrin specific peptidase 3
chr1_-_126830632 0.310 ENSMUST00000112583.1
ENSMUST00000094609.3
Nckap5

NCK-associated protein 5

chr8_-_4259257 0.307 ENSMUST00000053252.7
Ctxn1
cortexin 1
chr4_+_11191354 0.301 ENSMUST00000170901.1
Ccne2
cyclin E2
chr15_+_80623499 0.290 ENSMUST00000043149.7
Grap2
GRB2-related adaptor protein 2
chr4_+_42950369 0.284 ENSMUST00000084662.5
Dnajb5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr3_+_75557530 0.267 ENSMUST00000161776.1
ENSMUST00000029423.8
Serpini1

serine (or cysteine) peptidase inhibitor, clade I, member 1

chrX_+_42150672 0.263 ENSMUST00000069619.7
Stag2
stromal antigen 2
chr17_+_35135695 0.262 ENSMUST00000174478.1
ENSMUST00000174281.2
ENSMUST00000173550.1
Bag6


BCL2-associated athanogene 6


chr4_+_43641262 0.258 ENSMUST00000123351.1
ENSMUST00000128549.1
Npr2

natriuretic peptide receptor 2

chr18_-_36766198 0.256 ENSMUST00000061522.7
Dnd1
dead end homolog 1 (zebrafish)
chr19_+_21272276 0.256 ENSMUST00000025659.4
Zfand5
zinc finger, AN1-type domain 5
chr10_+_99263224 0.239 ENSMUST00000020118.4
Dusp6
dual specificity phosphatase 6
chr19_+_55894508 0.228 ENSMUST00000142291.1
Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr4_+_41760454 0.217 ENSMUST00000108040.1
Il11ra1
interleukin 11 receptor, alpha chain 1
chr10_-_86705485 0.211 ENSMUST00000020238.7
Hsp90b1
heat shock protein 90, beta (Grp94), member 1
chrX_+_42151002 0.210 ENSMUST00000123245.1
Stag2
stromal antigen 2
chr1_-_126830786 0.208 ENSMUST00000162646.1
Nckap5
NCK-associated protein 5
chr7_+_46796088 0.204 ENSMUST00000006774.4
ENSMUST00000165031.1
Gtf2h1

general transcription factor II H, polypeptide 1

chr16_+_19028232 0.191 ENSMUST00000074116.4
Gm10088
predicted gene 10088
chr6_-_48048911 0.173 ENSMUST00000095944.3
Zfp777
zinc finger protein 777
chr14_-_51988829 0.159 ENSMUST00000181008.1
Gm16617
predicted gene, 16617
chr9_+_87015537 0.155 ENSMUST00000058846.4
Ripply2
ripply2 homolog (zebrafish)
chr11_+_95414078 0.149 ENSMUST00000107724.2
ENSMUST00000150884.1
ENSMUST00000107722.1
ENSMUST00000127713.1
Spop



speckle-type POZ protein



chr11_-_84068357 0.138 ENSMUST00000100705.4
Dusp14
dual specificity phosphatase 14
chr14_+_56887795 0.127 ENSMUST00000022511.8
Zmym2
zinc finger, MYM-type 2
chr11_-_69681822 0.116 ENSMUST00000005336.2
Senp3
SUMO/sentrin specific peptidase 3
chr6_+_61180313 0.108 ENSMUST00000126214.1
Ccser1
coiled-coil serine rich 1
chr10_+_116177351 0.102 ENSMUST00000155606.1
ENSMUST00000128399.1
Ptprr

protein tyrosine phosphatase, receptor type, R

chr5_-_137786681 0.099 ENSMUST00000132726.1
Mepce
methylphosphate capping enzyme
chr13_-_96542479 0.087 ENSMUST00000022172.4
Polk
polymerase (DNA directed), kappa
chr8_+_122476143 0.072 ENSMUST00000116412.1
Ctu2
cytosolic thiouridylase subunit 2 homolog (S. pombe)
chr5_-_24601961 0.059 ENSMUST00000030791.7
Smarcd3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr6_-_127769427 0.051 ENSMUST00000032500.8
Prmt8
protein arginine N-methyltransferase 8
chr5_-_137786651 0.047 ENSMUST00000031740.9
Mepce
methylphosphate capping enzyme
chr12_-_56345862 0.038 ENSMUST00000021416.7
Mbip
MAP3K12 binding inhibitory protein 1
chrX_+_101383726 0.038 ENSMUST00000119190.1
Gjb1
gap junction protein, beta 1
chr8_+_122476196 0.038 ENSMUST00000146634.1
ENSMUST00000134127.1
Ctu2

cytosolic thiouridylase subunit 2 homolog (S. pombe)

chr7_+_130577334 0.033 ENSMUST00000059145.7
ENSMUST00000084513.4
Tacc2

transforming, acidic coiled-coil containing protein 2

chr2_+_25272475 0.016 ENSMUST00000028341.4
Anapc2
anaphase promoting complex subunit 2

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 4.0 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
2.0 7.9 GO:0051866 general adaptation syndrome(GO:0051866)
1.9 5.8 GO:0032474 otolith morphogenesis(GO:0032474)
1.9 9.3 GO:0035262 gonad morphogenesis(GO:0035262)
1.4 16.8 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
1.0 5.0 GO:0007386 compartment pattern specification(GO:0007386)
1.0 2.0 GO:0036118 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
1.0 2.9 GO:0003104 positive regulation of glomerular filtration(GO:0003104) cell communication by chemical coupling(GO:0010643)
0.9 3.8 GO:0030091 protein repair(GO:0030091)
0.9 9.6 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.8 2.5 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.8 11.4 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213) regulation of dopamine receptor signaling pathway(GO:0060159)
0.8 3.2 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.7 6.3 GO:0071493 cellular response to UV-B(GO:0071493)
0.6 5.3 GO:0090527 actin filament reorganization(GO:0090527)
0.6 4.7 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.6 1.7 GO:0015772 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.5 1.6 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.5 1.4 GO:0001951 intestinal D-glucose absorption(GO:0001951) terminal web assembly(GO:1902896)
0.5 1.4 GO:0045014 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) detection of glucose(GO:0051594)
0.4 1.8 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.4 1.6 GO:0007412 axon target recognition(GO:0007412)
0.3 2.9 GO:0010587 miRNA catabolic process(GO:0010587)
0.3 3.8 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.3 0.8 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.3 1.1 GO:0007262 STAT protein import into nucleus(GO:0007262)
0.3 0.8 GO:0006597 spermine biosynthetic process(GO:0006597)
0.2 0.7 GO:2000812 response to rapamycin(GO:1901355) regulation of barbed-end actin filament capping(GO:2000812)
0.2 2.8 GO:0099628 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
0.2 0.8 GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
0.2 1.1 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.2 0.7 GO:0014005 microglia differentiation(GO:0014004) microglia development(GO:0014005)
0.2 1.2 GO:0010572 positive regulation of platelet activation(GO:0010572)
0.2 0.5 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.2 2.4 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 0.9 GO:1900116 sequestering of extracellular ligand from receptor(GO:0035581) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1 1.0 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.1 4.9 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.1 0.9 GO:0071294 cellular response to zinc ion(GO:0071294)
0.1 0.4 GO:0035521 monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.1 0.7 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.1 3.1 GO:0007340 acrosome reaction(GO:0007340)
0.1 0.2 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.1 1.3 GO:0002227 innate immune response in mucosa(GO:0002227)
0.1 1.4 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.1 0.4 GO:0071638 negative regulation of monocyte chemotactic protein-1 production(GO:0071638)
0.1 1.2 GO:0060481 lobar bronchus epithelium development(GO:0060481)
0.1 0.7 GO:0071285 cellular response to lithium ion(GO:0071285)
0.1 16.4 GO:0050807 regulation of synapse organization(GO:0050807)
0.1 0.8 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.1 0.5 GO:1903847 regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.1 0.8 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.1 0.8 GO:0071384 cellular response to corticosteroid stimulus(GO:0071384) cellular response to glucocorticoid stimulus(GO:0071385)
0.1 0.9 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.1 0.4 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.1 1.3 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.1 0.1 GO:0003219 cardiac right ventricle formation(GO:0003219)
0.0 0.5 GO:2000035 regulation of stem cell division(GO:2000035)
0.0 1.7 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 0.6 GO:0007220 Notch receptor processing(GO:0007220)
0.0 6.4 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.0 0.5 GO:0006337 nucleosome disassembly(GO:0006337)
0.0 0.4 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.3 GO:0036506 maintenance of unfolded protein(GO:0036506) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.0 1.0 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.3 GO:1900194 negative regulation of oocyte development(GO:0060283) negative regulation of oocyte maturation(GO:1900194)
0.0 0.2 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.1 GO:0002143 tRNA wobble position uridine thiolation(GO:0002143)
0.0 0.2 GO:0071318 cellular response to ATP(GO:0071318)
0.0 0.1 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.0 0.5 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 0.3 GO:0060965 negative regulation of gene silencing by miRNA(GO:0060965)
0.0 0.1 GO:0035562 negative regulation of chromatin binding(GO:0035562)
0.0 1.1 GO:0021884 forebrain neuron development(GO:0021884)
0.0 0.6 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 0.3 GO:0034453 microtubule anchoring(GO:0034453)
0.0 0.7 GO:0008347 glial cell migration(GO:0008347)
0.0 0.8 GO:0009060 aerobic respiration(GO:0009060)
0.0 0.1 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.0 0.1 GO:0006297 nucleotide-excision repair, DNA gap filling(GO:0006297)
0.0 0.2 GO:0046697 decidualization(GO:0046697)
0.0 0.5 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.0 0.2 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.3 GO:0070557 PCNA-p21 complex(GO:0070557)
0.9 2.8 GO:0099573 glutamatergic postsynaptic density(GO:0099573)
0.5 3.2 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.3 1.2 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.3 11.4 GO:0032809 neuronal cell body membrane(GO:0032809)
0.3 1.1 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.3 9.6 GO:0032839 dendrite cytoplasm(GO:0032839)
0.3 1.4 GO:1990357 terminal web(GO:1990357)
0.3 2.8 GO:0005916 fascia adherens(GO:0005916)
0.2 1.3 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.2 1.1 GO:0001674 female germ cell nucleus(GO:0001674)
0.2 4.7 GO:0001741 XY body(GO:0001741)
0.2 1.6 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.2 12.4 GO:0005581 collagen trimer(GO:0005581)
0.1 0.6 GO:0097450 astrocyte end-foot(GO:0097450)
0.1 0.3 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.1 0.7 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.1 16.9 GO:0032993 protein-DNA complex(GO:0032993)
0.1 0.6 GO:0070765 gamma-secretase complex(GO:0070765)
0.1 1.0 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 0.3 GO:0031983 vesicle lumen(GO:0031983)
0.1 0.9 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 0.9 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.1 0.4 GO:0031415 NatA complex(GO:0031415)
0.0 1.7 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 2.9 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 2.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.3 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0 3.1 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 5.3 GO:0005884 actin filament(GO:0005884)
0.0 1.4 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.2 GO:0000439 core TFIIH complex(GO:0000439)
0.0 0.4 GO:0030061 mitochondrial crista(GO:0030061)
0.0 6.4 GO:0016607 nuclear speck(GO:0016607)
0.0 1.2 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.3 GO:0035097 histone methyltransferase complex(GO:0035097)
0.0 0.2 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.3 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.5 GO:0043034 costamere(GO:0043034)
0.0 2.6 GO:0005578 proteinaceous extracellular matrix(GO:0005578)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.3 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
1.9 9.6 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
1.2 6.2 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
1.1 3.2 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.7 2.9 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) gap junction channel activity involved in cell communication by electrical coupling(GO:1903763)
0.7 2.0 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.7 5.3 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.6 3.8 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.6 4.7 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.6 1.7 GO:0008515 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.4 1.8 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.3 1.2 GO:0042806 fucose binding(GO:0042806)
0.3 1.2 GO:0050436 microfibril binding(GO:0050436)
0.3 0.8 GO:0031752 D3 dopamine receptor binding(GO:0031750) D5 dopamine receptor binding(GO:0031752)
0.3 11.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.3 1.6 GO:0070728 leucine binding(GO:0070728)
0.3 2.9 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.3 2.5 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.2 3.7 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.2 2.8 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.2 1.1 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.2 1.1 GO:0038132 neuregulin binding(GO:0038132)
0.2 0.8 GO:0019808 polyamine binding(GO:0019808)
0.2 1.3 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.1 5.0 GO:0005112 Notch binding(GO:0005112)
0.1 0.9 GO:0036122 BMP binding(GO:0036122)
0.1 0.4 GO:0086038 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038)
0.1 2.4 GO:0008432 JUN kinase binding(GO:0008432)
0.1 0.9 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.1 8.0 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1 0.8 GO:1990226 histone methyltransferase binding(GO:1990226)
0.1 0.2 GO:0004921 interleukin-11 receptor activity(GO:0004921) interleukin-11 binding(GO:0019970)
0.1 0.9 GO:0016595 glutamate binding(GO:0016595)
0.1 0.5 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 6.4 GO:0001047 core promoter binding(GO:0001047)
0.0 0.8 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 1.1 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.5 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.8 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.5 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.4 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.0 0.4 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.6 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.2 GO:0046790 virion binding(GO:0046790)
0.0 1.4 GO:0097110 scaffold protein binding(GO:0097110)
0.0 0.3 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.1 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.7 GO:0005504 fatty acid binding(GO:0005504)
0.0 4.4 GO:0000287 magnesium ion binding(GO:0000287)
0.0 0.3 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.4 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 1.0 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 0.7 GO:0035254 glutamate receptor binding(GO:0035254)
0.0 0.4 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.3 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 2.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.1 GO:0016783 sulfurtransferase activity(GO:0016783)
0.0 0.1 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 6.3 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 2.8 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 12.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 6.1 PID_ERBB4_PATHWAY ErbB4 signaling events
0.1 3.2 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling
0.1 5.6 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 3.9 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.0 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.6 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 2.9 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.4 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.3 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.3 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 1.2 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.0 1.4 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 0.8 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.3 PID_FOXO_PATHWAY FoxO family signaling
0.0 0.8 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 0.5 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.9 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 0.7 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 0.8 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 0.9 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 9.6 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.4 1.8 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.3 2.5 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.2 2.9 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.2 6.3 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.2 3.7 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 2.0 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.1 4.1 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.1 4.0 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 1.4 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.1 10.6 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 0.8 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.1 0.9 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1 1.6 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 2.6 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.9 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 1.7 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.0 0.6 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.7 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 1.1 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.8 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 0.9 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 0.2 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.0 0.2 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 1.1 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 1.2 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.3 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.5 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.3 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.0 2.8 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation