Motif ID: Cdc5l

Z-value: 0.715


Transcription factors associated with Cdc5l:

Gene SymbolEntrez IDGene Name
Cdc5l ENSMUSG00000023932.8 Cdc5l

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Cdc5lmm10_v2_chr17_-_45433682_454337090.076.4e-01Click!


Activity profile for motif Cdc5l.

activity profile for motif Cdc5l


Sorted Z-values histogram for motif Cdc5l

Sorted Z-values for motif Cdc5l



Network of associatons between targets according to the STRING database.



First level regulatory network of Cdc5l

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_-_22850738 4.167 ENSMUST00000092015.4
ENSMUST00000069215.6
Nol4

nucleolar protein 4

chr5_+_107497762 4.128 ENSMUST00000152474.1
ENSMUST00000060553.7
A830010M20Rik

RIKEN cDNA A830010M20 gene

chr5_+_107497718 3.600 ENSMUST00000112671.2
A830010M20Rik
RIKEN cDNA A830010M20 gene
chr12_+_29528382 3.399 ENSMUST00000049784.9
Myt1l
myelin transcription factor 1-like
chr2_+_65620829 3.052 ENSMUST00000028377.7
Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr19_-_5797410 2.952 ENSMUST00000173314.1
Malat1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chr5_+_66968559 2.620 ENSMUST00000127184.1
Limch1
LIM and calponin homology domains 1
chr18_-_31447383 2.587 ENSMUST00000025110.3
Syt4
synaptotagmin IV
chr3_-_49757257 2.181 ENSMUST00000035931.7
Pcdh18
protocadherin 18
chr1_+_180111339 2.172 ENSMUST00000145181.1
Cdc42bpa
CDC42 binding protein kinase alpha
chr9_-_96752822 2.094 ENSMUST00000152594.1
Zbtb38
zinc finger and BTB domain containing 38
chr9_-_112187898 2.080 ENSMUST00000178410.1
ENSMUST00000172380.3
Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr5_+_66968416 2.034 ENSMUST00000038188.7
Limch1
LIM and calponin homology domains 1
chr9_-_55919605 1.978 ENSMUST00000037408.8
Scaper
S phase cyclin A-associated protein in the ER
chr17_-_78684262 1.970 ENSMUST00000145480.1
Strn
striatin, calmodulin binding protein
chr9_-_112187766 1.855 ENSMUST00000111872.2
ENSMUST00000164754.2
Arpp21

cyclic AMP-regulated phosphoprotein, 21

chrX_+_136822781 1.761 ENSMUST00000113085.1
Plp1
proteolipid protein (myelin) 1
chr10_+_17723220 1.616 ENSMUST00000038107.7
Cited2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
chr7_+_112742025 1.587 ENSMUST00000164363.1
Tead1
TEA domain family member 1
chr11_-_50953745 1.450 ENSMUST00000162420.1
ENSMUST00000051159.2
Prop1

paired like homeodomain factor 1

chrX_+_136822671 1.437 ENSMUST00000033800.6
Plp1
proteolipid protein (myelin) 1
chr19_+_26749726 1.399 ENSMUST00000175842.1
Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr2_-_72986716 1.275 ENSMUST00000112062.1
Gm11084
predicted gene 11084
chr6_+_86526271 1.215 ENSMUST00000180896.1
1600020E01Rik
RIKEN cDNA 1600020E01 gene
chr1_-_30863256 1.211 ENSMUST00000088310.3
Phf3
PHD finger protein 3
chrX_-_37104523 1.095 ENSMUST00000130324.1
Upf3b
UPF3 regulator of nonsense transcripts homolog B (yeast)
chr12_+_74297474 1.081 ENSMUST00000072100.3
Dbpht2
DNA binding protein with his-thr domain
chr1_+_17601893 0.956 ENSMUST00000088476.2
Pi15
peptidase inhibitor 15
chr2_-_64975762 0.801 ENSMUST00000156765.1
Grb14
growth factor receptor bound protein 14
chr10_-_127189981 0.723 ENSMUST00000019611.7
Arhgef25
Rho guanine nucleotide exchange factor (GEF) 25
chr4_-_149126688 0.698 ENSMUST00000030815.2
Cort
cortistatin
chr1_+_143640664 0.693 ENSMUST00000038252.2
B3galt2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr1_-_97761538 0.672 ENSMUST00000171129.1
Ppip5k2
diphosphoinositol pentakisphosphate kinase 2
chr7_-_103741322 0.565 ENSMUST00000051346.2
Olfr629
olfactory receptor 629
chr4_+_95967205 0.445 ENSMUST00000030306.7
Hook1
hook homolog 1 (Drosophila)
chr5_-_31220491 0.397 ENSMUST00000031032.7
Ppm1g
protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform
chr7_+_130577334 0.029 ENSMUST00000059145.7
ENSMUST00000084513.4
Tacc2

transforming, acidic coiled-coil containing protein 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.0 GO:0035063 nuclear speck organization(GO:0035063)
0.5 1.4 GO:0060126 hypophysis morphogenesis(GO:0048850) somatotropin secreting cell differentiation(GO:0060126)
0.4 1.6 GO:0061428 embryonic heart tube left/right pattern formation(GO:0060971) negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428)
0.3 2.6 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.3 0.8 GO:1903538 meiotic cell cycle process involved in oocyte maturation(GO:1903537) regulation of meiotic cell cycle process involved in oocyte maturation(GO:1903538)
0.2 3.2 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.2 1.4 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.1 1.6 GO:0014883 transition between fast and slow fiber(GO:0014883)
0.1 2.2 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 3.4 GO:0048665 neuron fate specification(GO:0048665)
0.1 0.7 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.1 2.2 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.1 3.9 GO:0034605 cellular response to heat(GO:0034605)
0.1 0.7 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.7 GO:0045187 regulation of circadian sleep/wake cycle(GO:0042749) regulation of circadian sleep/wake cycle, sleep(GO:0045187)
0.0 0.4 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.0 1.1 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 4.7 GO:0031032 actomyosin structure organization(GO:0031032)
0.0 2.1 GO:0006275 regulation of DNA replication(GO:0006275)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.6 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.2 2.6 GO:0097449 astrocyte projection(GO:0097449)
0.1 2.0 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 1.4 GO:0071564 npBAF complex(GO:0071564)
0.1 0.4 GO:0070695 FHF complex(GO:0070695)
0.0 1.1 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 2.1 GO:0072562 blood microparticle(GO:0072562)
0.0 2.2 GO:0042641 actomyosin(GO:0042641)
0.0 3.2 GO:0043209 myelin sheath(GO:0043209)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.6 GO:0030348 syntaxin-3 binding(GO:0030348)
0.4 3.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.3 3.4 GO:0050897 cobalt ion binding(GO:0050897)
0.2 0.7 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.2 0.7 GO:0000832 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.1 1.4 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.1 1.6 GO:0050693 LBD domain binding(GO:0050693)
0.1 0.6 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 2.0 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 2.1 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 1.6 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.0 0.7 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 1.4 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.8 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 3.9 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.4 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.0 4.7 GO:0003779 actin binding(GO:0003779)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.6 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 2.0 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling
0.0 2.2 PID_CDC42_PATHWAY CDC42 signaling events
0.0 0.8 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.7 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 1.4 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.8 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 1.1 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing