Motif ID: Nkx2-2

Z-value: 1.529


Transcription factors associated with Nkx2-2:

Gene SymbolEntrez IDGene Name
Nkx2-2 ENSMUSG00000027434.10 Nkx2-2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-2mm10_v2_chr2_-_147186389_1471864130.095.7e-01Click!


Activity profile for motif Nkx2-2.

activity profile for motif Nkx2-2


Sorted Z-values histogram for motif Nkx2-2

Sorted Z-values for motif Nkx2-2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_3018753 9.147 ENSMUST00000179272.1
Gm10719
predicted gene 10719
chr14_-_19418930 9.003 ENSMUST00000177817.1
Gm21738
predicted gene, 21738
chr9_+_3034599 8.324 ENSMUST00000178641.1
Gm17535
predicted gene, 17535
chr9_+_3025417 7.766 ENSMUST00000075573.6
Gm10717
predicted gene 10717
chr9_+_3005125 7.559 ENSMUST00000179881.1
Gm11168
predicted gene 11168
chr9_+_3015654 7.520 ENSMUST00000099050.3
Gm10720
predicted gene 10720
chr9_+_3017408 7.302 ENSMUST00000099049.3
Gm10719
predicted gene 10719
chr3_+_118433797 5.362 ENSMUST00000180593.1
ENSMUST00000181926.1
ENSMUST00000181060.1
ENSMUST00000181310.1
Gm26871



predicted gene, 26871



chr3_+_5218516 4.754 ENSMUST00000175866.1
Zfhx4
zinc finger homeodomain 4
chr1_-_166002613 3.858 ENSMUST00000177358.1
ENSMUST00000160908.1
ENSMUST00000027850.8
ENSMUST00000160260.2
Pou2f1



POU domain, class 2, transcription factor 1



chr19_-_5796924 3.810 ENSMUST00000174808.1
Malat1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chr3_-_49757257 3.519 ENSMUST00000035931.7
Pcdh18
protocadherin 18
chr2_+_62664279 3.453 ENSMUST00000028257.2
Gca
grancalcin
chr15_-_10470490 3.021 ENSMUST00000136591.1
Dnajc21
DnaJ (Hsp40) homolog, subfamily C, member 21
chr2_-_140170528 2.835 ENSMUST00000046030.7
Esf1
ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)
chr1_-_135688094 2.701 ENSMUST00000112103.1
Nav1
neuron navigator 1
chr5_-_123141067 2.687 ENSMUST00000162697.1
ENSMUST00000160321.1
ENSMUST00000159637.1
AI480526


expressed sequence AI480526


chrX_+_9885622 2.637 ENSMUST00000067529.2
ENSMUST00000086165.3
Sytl5

synaptotagmin-like 5

chr13_-_41487306 2.630 ENSMUST00000021794.6
Nedd9
neural precursor cell expressed, developmentally down-regulated gene 9
chr15_-_8710734 2.618 ENSMUST00000005493.7
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr10_-_33995054 2.564 ENSMUST00000164429.1
Gm17567
predicted gene, 17567
chr4_+_46039202 2.552 ENSMUST00000156200.1
Tmod1
tropomodulin 1
chr9_+_72438534 2.543 ENSMUST00000034746.8
Mns1
meiosis-specific nuclear structural protein 1
chr1_-_152386589 2.437 ENSMUST00000162371.1
Tsen15
tRNA splicing endonuclease 15 homolog (S. cerevisiae)
chr9_-_96719549 2.419 ENSMUST00000128269.1
Zbtb38
zinc finger and BTB domain containing 38
chrX_+_106027259 2.392 ENSMUST00000113557.1
Atp7a
ATPase, Cu++ transporting, alpha polypeptide
chr12_+_32953874 2.328 ENSMUST00000076698.5
Sypl
synaptophysin-like protein
chr5_-_123140135 2.308 ENSMUST00000160099.1
AI480526
expressed sequence AI480526
chr5_-_69592274 2.200 ENSMUST00000174233.1
ENSMUST00000120789.1
ENSMUST00000166298.1
Gnpda2


glucosamine-6-phosphate deaminase 2


chr3_-_84304762 2.168 ENSMUST00000107692.1
Trim2
tripartite motif-containing 2
chr9_-_96719404 2.163 ENSMUST00000140121.1
Zbtb38
zinc finger and BTB domain containing 38
chr9_+_72438519 2.145 ENSMUST00000184604.1
Mns1
meiosis-specific nuclear structural protein 1
chrX_+_106027300 2.050 ENSMUST00000055941.6
Atp7a
ATPase, Cu++ transporting, alpha polypeptide
chr18_+_32163073 2.037 ENSMUST00000096575.3
Map3k2
mitogen-activated protein kinase kinase kinase 2
chr8_+_69300776 2.012 ENSMUST00000078257.6
D130040H23Rik
RIKEN cDNA D130040H23 gene
chr7_-_6011010 1.990 ENSMUST00000086338.1
Vmn1r65
vomeronasal 1 receptor 65
chr2_+_174076296 1.968 ENSMUST00000155000.1
ENSMUST00000134876.1
ENSMUST00000147038.1
Stx16


syntaxin 16


chr4_+_115563649 1.958 ENSMUST00000141033.1
ENSMUST00000030486.8
ENSMUST00000126645.1
ENSMUST00000030480.3
Cyp4a31



cytochrome P450, family 4, subfamily a, polypeptide 31



chr8_+_41239718 1.899 ENSMUST00000045218.7
Pcm1
pericentriolar material 1
chr3_+_5218546 1.848 ENSMUST00000026284.6
Zfhx4
zinc finger homeodomain 4
chr2_+_52072823 1.821 ENSMUST00000112693.2
ENSMUST00000069794.5
Rif1

Rap1 interacting factor 1 homolog (yeast)

chr16_-_16527364 1.717 ENSMUST00000069284.7
Fgd4
FYVE, RhoGEF and PH domain containing 4
chr14_+_47663756 1.674 ENSMUST00000022391.7
Ktn1
kinectin 1
chr13_-_103764502 1.626 ENSMUST00000074616.5
Srek1
splicing regulatory glutamine/lysine-rich protein 1
chr13_-_85127514 1.605 ENSMUST00000179230.1
Gm4076
predicted gene 4076
chr15_+_75704280 1.556 ENSMUST00000121137.1
ENSMUST00000023244.5
Rhpn1

rhophilin, Rho GTPase binding protein 1

chr10_+_19951055 1.533 ENSMUST00000152533.1
Map3k5
mitogen-activated protein kinase kinase kinase 5
chr5_-_3596071 1.526 ENSMUST00000121877.1
Rbm48
RNA binding motif protein 48
chr7_-_123369870 1.499 ENSMUST00000106442.2
ENSMUST00000098060.3
ENSMUST00000167309.1
Arhgap17


Rho GTPase activating protein 17


chr17_+_43568641 1.483 ENSMUST00000169694.1
Pla2g7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr10_+_106470281 1.478 ENSMUST00000029404.9
ENSMUST00000169303.1
Ppfia2

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2

chr3_+_14533817 1.475 ENSMUST00000169079.1
ENSMUST00000091325.3
Lrrcc1

leucine rich repeat and coiled-coil domain containing 1

chr5_+_3596066 1.408 ENSMUST00000006061.6
ENSMUST00000121291.1
ENSMUST00000142516.1
Pex1


peroxisomal biogenesis factor 1


chr6_+_143285988 1.395 ENSMUST00000160951.1
D6Ertd474e
DNA segment, Chr 6, ERATO Doi 474, expressed
chr1_-_152386675 1.394 ENSMUST00000015124.8
Tsen15
tRNA splicing endonuclease 15 homolog (S. cerevisiae)
chr3_+_62419668 1.384 ENSMUST00000161057.1
Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr16_+_14705832 1.371 ENSMUST00000023356.6
Snai2
snail homolog 2 (Drosophila)
chrM_+_11734 1.315 ENSMUST00000082418.1
mt-Nd5
mitochondrially encoded NADH dehydrogenase 5
chr13_+_33964659 1.298 ENSMUST00000021843.5
ENSMUST00000058978.7
Nqo2

NAD(P)H dehydrogenase, quinone 2

chr12_-_100899436 1.207 ENSMUST00000053668.3
Gpr68
G protein-coupled receptor 68
chr3_+_138143429 1.201 ENSMUST00000040321.6
Trmt10a
tRNA methyltransferase 10A
chr17_+_43568475 1.199 ENSMUST00000167418.1
Pla2g7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr1_-_88008520 1.196 ENSMUST00000040783.4
Usp40
ubiquitin specific peptidase 40
chr8_+_40354303 1.185 ENSMUST00000136835.1
Micu3
mitochondrial calcium uptake family, member 3
chr2_-_77946375 1.155 ENSMUST00000065889.3
Cwc22
CWC22 spliceosome-associated protein homolog (S. cerevisiae)
chr10_+_93897156 1.155 ENSMUST00000180815.1
4930471D02Rik
RIKEN cDNA 4930471D02 gene
chr2_-_77946331 1.148 ENSMUST00000111821.2
ENSMUST00000111818.1
Cwc22

CWC22 spliceosome-associated protein homolog (S. cerevisiae)

chr3_+_81932601 1.146 ENSMUST00000029649.2
Ctso
cathepsin O
chr2_+_23069210 1.130 ENSMUST00000155602.1
Acbd5
acyl-Coenzyme A binding domain containing 5
chr19_-_29753600 1.125 ENSMUST00000175764.1
9930021J03Rik
RIKEN cDNA 9930021J03 gene
chrX_+_6415736 1.122 ENSMUST00000143641.3
Shroom4
shroom family member 4
chr6_-_108185552 1.104 ENSMUST00000167338.1
ENSMUST00000172188.1
ENSMUST00000032191.9
Sumf1


sulfatase modifying factor 1


chr9_+_35559460 1.082 ENSMUST00000034615.3
ENSMUST00000121246.1
Pus3

pseudouridine synthase 3

chr7_-_80403315 1.081 ENSMUST00000147150.1
Furin
furin (paired basic amino acid cleaving enzyme)
chr13_-_38037069 1.042 ENSMUST00000089840.4
Cage1
cancer antigen 1
chr1_-_16093286 1.026 ENSMUST00000145070.1
ENSMUST00000151004.1
4930444P10Rik

RIKEN cDNA 4930444P10 gene

chr17_-_15564322 1.025 ENSMUST00000147532.1
Prdm9
PR domain containing 9
chr6_+_8520008 1.020 ENSMUST00000162567.1
ENSMUST00000161217.1
Glcci1

glucocorticoid induced transcript 1

chr2_+_102706356 1.010 ENSMUST00000123759.1
ENSMUST00000111212.1
ENSMUST00000005220.4
Slc1a2


solute carrier family 1 (glial high affinity glutamate transporter), member 2


chr4_+_59626189 1.003 ENSMUST00000070150.4
ENSMUST00000052420.6
E130308A19Rik

RIKEN cDNA E130308A19 gene

chr5_+_110839973 1.002 ENSMUST00000066160.1
Chek2
checkpoint kinase 2
chr3_+_138143888 0.991 ENSMUST00000161141.1
Trmt10a
tRNA methyltransferase 10A
chr2_-_114013619 0.989 ENSMUST00000090275.4
Gjd2
gap junction protein, delta 2
chr3_+_138143846 0.977 ENSMUST00000159481.1
Trmt10a
tRNA methyltransferase 10A
chr13_-_64274962 0.970 ENSMUST00000039318.8
Cdc14b
CDC14 cell division cycle 14B
chr3_+_138143483 0.968 ENSMUST00000162864.1
Trmt10a
tRNA methyltransferase 10A
chr7_+_29768552 0.955 ENSMUST00000032802.4
Zfp84
zinc finger protein 84
chr3_+_52268337 0.949 ENSMUST00000053764.5
Foxo1
forkhead box O1
chr2_-_84775420 0.944 ENSMUST00000111641.1
Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr12_+_59129720 0.942 ENSMUST00000175912.1
ENSMUST00000176892.1
Ctage5

CTAGE family, member 5

chr13_-_18382041 0.938 ENSMUST00000139064.2
ENSMUST00000175703.2
Pou6f2

POU domain, class 6, transcription factor 2

chr17_-_32822200 0.922 ENSMUST00000179695.1
Zfp799
zinc finger protein 799
chr9_+_74976096 0.908 ENSMUST00000081746.5
Fam214a
family with sequence similarity 214, member A
chrX_+_68821093 0.907 ENSMUST00000096420.2
Gm14698
predicted gene 14698
chr1_+_82339049 0.878 ENSMUST00000140020.1
Rhbdd1
rhomboid domain containing 1
chr2_+_140152043 0.876 ENSMUST00000104994.2
Gm17374
predicted gene, 17374
chr2_+_69897255 0.866 ENSMUST00000131553.1
Ubr3
ubiquitin protein ligase E3 component n-recognin 3
chr19_-_40402267 0.865 ENSMUST00000099467.3
ENSMUST00000099466.3
ENSMUST00000165212.1
ENSMUST00000165469.1
Sorbs1



sorbin and SH3 domain containing 1



chr14_+_51884982 0.864 ENSMUST00000167984.1
Mettl17
methyltransferase like 17
chr3_+_138143799 0.863 ENSMUST00000159622.1
Trmt10a
tRNA methyltransferase 10A
chr2_-_84775388 0.827 ENSMUST00000023994.3
Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr6_-_38046994 0.826 ENSMUST00000096040.4
Svopl
SV2 related protein homolog (rat)-like
chr5_-_30073554 0.820 ENSMUST00000026846.6
Tyms
thymidylate synthase
chr10_-_54075702 0.818 ENSMUST00000105470.1
Man1a
mannosidase 1, alpha
chr4_+_116558056 0.810 ENSMUST00000106475.1
Gpbp1l1
GC-rich promoter binding protein 1-like 1
chr6_+_3993776 0.788 ENSMUST00000031673.5
Gngt1
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr9_-_8004585 0.760 ENSMUST00000086580.5
ENSMUST00000065353.6
Yap1

yes-associated protein 1

chr5_+_105876532 0.741 ENSMUST00000150440.1
ENSMUST00000031227.4
Zfp326

zinc finger protein 326

chr6_-_120357342 0.731 ENSMUST00000163827.1
Ccdc77
coiled-coil domain containing 77
chr2_+_83644435 0.726 ENSMUST00000081591.6
Zc3h15
zinc finger CCCH-type containing 15
chr2_-_26237368 0.719 ENSMUST00000036187.8
Qsox2
quiescin Q6 sulfhydryl oxidase 2
chr5_+_149439706 0.700 ENSMUST00000031667.4
Tex26
testis expressed 26
chrX_+_73673150 0.697 ENSMUST00000033752.7
ENSMUST00000114467.2
Slc6a8

solute carrier family 6 (neurotransmitter transporter, creatine), member 8

chr14_-_54686060 0.693 ENSMUST00000125265.1
Acin1
apoptotic chromatin condensation inducer 1
chr9_-_119322421 0.682 ENSMUST00000040853.4
Oxsr1
oxidative-stress responsive 1
chr14_-_72602945 0.680 ENSMUST00000162825.1
Fndc3a
fibronectin type III domain containing 3A
chr13_-_29855630 0.634 ENSMUST00000091674.5
ENSMUST00000006353.7
Cdkal1

CDK5 regulatory subunit associated protein 1-like 1

chr2_+_3704787 0.627 ENSMUST00000115054.2
Fam107b
family with sequence similarity 107, member B
chr12_+_111039334 0.625 ENSMUST00000084968.7
Rcor1
REST corepressor 1
chr10_-_54075730 0.621 ENSMUST00000105469.1
ENSMUST00000003843.8
Man1a

mannosidase 1, alpha

chr18_-_84951477 0.620 ENSMUST00000025547.2
Timm21
tranlocase of inner mitochondrial membrane 21
chr13_+_38036989 0.604 ENSMUST00000021866.8
Riok1
RIO kinase 1 (yeast)
chr7_+_112374839 0.603 ENSMUST00000106645.1
Micalcl
MICAL C-terminal like
chr18_-_6241470 0.595 ENSMUST00000163210.1
Kif5b
kinesin family member 5B
chr2_-_26380600 0.586 ENSMUST00000114115.2
ENSMUST00000035427.4
Snapc4

small nuclear RNA activating complex, polypeptide 4

chr7_-_43533171 0.578 ENSMUST00000004728.5
ENSMUST00000039861.5
Cd33

CD33 antigen

chr5_+_66968416 0.571 ENSMUST00000038188.7
Limch1
LIM and calponin homology domains 1
chr6_-_70792155 0.561 ENSMUST00000066134.5
Rpia
ribose 5-phosphate isomerase A
chr11_-_69900886 0.556 ENSMUST00000108621.2
ENSMUST00000100969.2
2810408A11Rik

RIKEN cDNA 2810408A11 gene

chr1_+_179960472 0.550 ENSMUST00000097453.2
ENSMUST00000111117.1
Cdc42bpa

CDC42 binding protein kinase alpha

chr1_+_179961110 0.549 ENSMUST00000076687.5
ENSMUST00000097450.3
Cdc42bpa

CDC42 binding protein kinase alpha

chr15_-_58034289 0.545 ENSMUST00000100655.3
9130401M01Rik
RIKEN cDNA 9130401M01 gene
chr11_-_69900930 0.540 ENSMUST00000018714.6
ENSMUST00000128046.1
2810408A11Rik

RIKEN cDNA 2810408A11 gene

chr18_-_6241486 0.538 ENSMUST00000025083.7
Kif5b
kinesin family member 5B
chr18_-_73754457 0.524 ENSMUST00000041138.2
Elac1
elaC homolog 1 (E. coli)
chr10_-_12861735 0.520 ENSMUST00000076817.4
Utrn
utrophin
chr4_+_126024506 0.505 ENSMUST00000106162.1
Csf3r
colony stimulating factor 3 receptor (granulocyte)
chr17_+_71616215 0.504 ENSMUST00000047086.9
Wdr43
WD repeat domain 43
chr14_-_59395381 0.503 ENSMUST00000166912.2
Phf11c
PHD finger protein 11C
chr13_+_104178797 0.501 ENSMUST00000022225.5
ENSMUST00000069187.5
Trim23

tripartite motif-containing 23

chr11_+_97685903 0.491 ENSMUST00000107583.2
Cisd3
CDGSH iron sulfur domain 3
chr6_-_120357440 0.482 ENSMUST00000112703.1
Ccdc77
coiled-coil domain containing 77
chr14_+_76476913 0.460 ENSMUST00000140251.2
Tsc22d1
TSC22 domain family, member 1
chr12_+_74297474 0.459 ENSMUST00000072100.3
Dbpht2
DNA binding protein with his-thr domain
chr15_-_73184840 0.452 ENSMUST00000044113.10
Ago2
argonaute RISC catalytic subunit 2
chr3_+_30792876 0.448 ENSMUST00000029256.7
Sec62
SEC62 homolog (S. cerevisiae)
chr18_+_12972225 0.446 ENSMUST00000025290.5
Impact
imprinted and ancient
chr10_+_126978690 0.435 ENSMUST00000105256.2
Ctdsp2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
chrX_+_101274023 0.427 ENSMUST00000117706.1
Med12
mediator of RNA polymerase II transcription, subunit 12 homolog (yeast)
chr1_-_9748376 0.423 ENSMUST00000057438.6
Vcpip1
valosin containing protein (p97)/p47 complex interacting protein 1
chr4_+_3940747 0.422 ENSMUST00000119403.1
Chchd7
coiled-coil-helix-coiled-coil-helix domain containing 7
chr7_+_19345135 0.417 ENSMUST00000160369.1
Ercc1
excision repair cross-complementing rodent repair deficiency, complementation group 1
chr4_-_15149755 0.417 ENSMUST00000108273.1
Necab1
N-terminal EF-hand calcium binding protein 1
chr2_+_32535724 0.395 ENSMUST00000133366.1
Fam102a
family with sequence similarity 102, member A
chr3_+_65528457 0.393 ENSMUST00000130705.1
Tiparp
TCDD-inducible poly(ADP-ribose) polymerase
chr12_+_105784694 0.391 ENSMUST00000109901.2
ENSMUST00000168186.1
ENSMUST00000163473.1
ENSMUST00000170540.1
ENSMUST00000166735.1
ENSMUST00000170002.1
Papola





poly (A) polymerase alpha





chr11_-_71004387 0.389 ENSMUST00000124464.1
ENSMUST00000108527.1
Dhx33

DEAH (Asp-Glu-Ala-His) box polypeptide 33

chr14_-_104522615 0.388 ENSMUST00000022716.2
Rnf219
ring finger protein 219
chr11_-_69900949 0.378 ENSMUST00000102580.3
2810408A11Rik
RIKEN cDNA 2810408A11 gene
chr5_+_66968559 0.375 ENSMUST00000127184.1
Limch1
LIM and calponin homology domains 1
chr6_-_59426279 0.371 ENSMUST00000051065.4
Gprin3
GPRIN family member 3
chr1_-_176807124 0.371 ENSMUST00000057037.7
Cep170
centrosomal protein 170
chr18_-_61786636 0.370 ENSMUST00000120472.1
Afap1l1
actin filament associated protein 1-like 1
chr6_-_120357422 0.354 ENSMUST00000032283.5
Ccdc77
coiled-coil domain containing 77
chr16_+_14580221 0.352 ENSMUST00000147024.1
A630010A05Rik
RIKEN cDNA A630010A05 gene
chr17_-_65884902 0.341 ENSMUST00000024905.9
Ralbp1
ralA binding protein 1
chr16_-_33967032 0.335 ENSMUST00000023510.6
Umps
uridine monophosphate synthetase
chrX_+_164980592 0.310 ENSMUST00000101082.4
ENSMUST00000167446.1
ENSMUST00000057150.6
Fancb


Fanconi anemia, complementation group B


chr2_-_73453918 0.301 ENSMUST00000102679.1
Wipf1
WAS/WASL interacting protein family, member 1
chr3_+_65528404 0.297 ENSMUST00000047906.3
Tiparp
TCDD-inducible poly(ADP-ribose) polymerase
chr18_+_37513652 0.262 ENSMUST00000061405.4
Pcdhb21
protocadherin beta 21
chr17_+_79051906 0.252 ENSMUST00000040789.4
Qpct
glutaminyl-peptide cyclotransferase (glutaminyl cyclase)
chr4_+_125029992 0.245 ENSMUST00000030684.7
Gnl2
guanine nucleotide binding protein-like 2 (nucleolar)
chr17_-_83631892 0.244 ENSMUST00000051482.1
Kcng3
potassium voltage-gated channel, subfamily G, member 3
chr19_+_6241668 0.222 ENSMUST00000045351.6
Atg2a
autophagy related 2A
chr19_+_8819401 0.185 ENSMUST00000096753.3
Hnrnpul2
heterogeneous nuclear ribonucleoprotein U-like 2
chr2_-_25575224 0.184 ENSMUST00000039156.6
Phpt1
phosphohistidine phosphatase 1
chr7_+_44836286 0.177 ENSMUST00000033015.7
Il4i1
interleukin 4 induced 1
chr3_+_76075583 0.174 ENSMUST00000160261.1
Fstl5
follistatin-like 5
chr10_-_13388830 0.167 ENSMUST00000079698.5
Phactr2
phosphatase and actin regulator 2
chr13_+_21478907 0.151 ENSMUST00000062609.5
Zkscan4
zinc finger with KRAB and SCAN domains 4
chr2_+_71873224 0.142 ENSMUST00000006669.5
Pdk1
pyruvate dehydrogenase kinase, isoenzyme 1
chr6_+_145953429 0.138 ENSMUST00000111701.1
Sspn
sarcospan
chr11_-_110251736 0.133 ENSMUST00000044003.7
Abca6
ATP-binding cassette, sub-family A (ABC1), member 6
chr5_+_66968961 0.117 ENSMUST00000132991.1
Limch1
LIM and calponin homology domains 1
chr11_+_3649759 0.115 ENSMUST00000140242.1
Morc2a
microrchidia 2A
chr12_-_91849081 0.107 ENSMUST00000167466.1
ENSMUST00000021347.5
ENSMUST00000178462.1
Sel1l


sel-1 suppressor of lin-12-like (C. elegans)


chr8_+_105880875 0.088 ENSMUST00000040254.9
ENSMUST00000119261.1
Edc4

enhancer of mRNA decapping 4

chrX_-_101420206 0.077 ENSMUST00000118092.1
Zmym3
zinc finger, MYM-type 3
chr18_+_4993795 0.069 ENSMUST00000153016.1
Svil
supervillin
chr9_+_14860210 0.052 ENSMUST00000034408.5
ENSMUST00000115624.2
Gpr83

G protein-coupled receptor 83

chr18_+_37504264 0.041 ENSMUST00000052179.6
Pcdhb20
protocadherin beta 20
chr6_+_94500313 0.038 ENSMUST00000061118.8
Slc25a26
solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26
chr11_+_57518657 0.008 ENSMUST00000108849.1
ENSMUST00000020830.7
Mfap3

microfibrillar-associated protein 3

chr6_+_82041623 0.007 ENSMUST00000042974.8
Eva1a
eva-1 homolog A (C. elegans)
chr6_-_85451248 0.001 ENSMUST00000113770.1
ENSMUST00000032080.2
Pradc1

protease-associated domain containing 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.4 GO:1904959 elastin biosynthetic process(GO:0051542) copper ion export(GO:0060003) regulation of electron carrier activity(GO:1904732) regulation of cytochrome-c oxidase activity(GO:1904959)
0.8 3.8 GO:0035063 nuclear speck organization(GO:0035063)
0.7 2.6 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.6 1.8 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.6 3.9 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.5 2.7 GO:0034441 plasma lipoprotein particle oxidation(GO:0034441)
0.5 2.6 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.5 1.4 GO:1901420 negative regulation of response to alcohol(GO:1901420)
0.4 1.2 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.4 1.8 GO:2001032 regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.3 1.0 GO:0010845 positive regulation of reciprocal meiotic recombination(GO:0010845)
0.3 4.7 GO:0070986 left/right axis specification(GO:0070986)
0.3 0.9 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.3 3.8 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.3 1.9 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.3 1.1 GO:0090472 dibasic protein processing(GO:0090472)
0.3 1.0 GO:1903463 regulation of mitotic cell cycle DNA replication(GO:1903463)
0.2 0.7 GO:2000686 regulation of rubidium ion transmembrane transporter activity(GO:2000686)
0.2 1.1 GO:0035617 stress granule disassembly(GO:0035617) plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386) regulation of voltage-gated sodium channel activity(GO:1905150)
0.2 0.9 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.2 0.4 GO:0000720 pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)
0.2 0.8 GO:0046073 dTMP biosynthetic process(GO:0006231) dTMP metabolic process(GO:0046073)
0.2 1.0 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.2 1.7 GO:0030035 microspike assembly(GO:0030035)
0.2 1.1 GO:0090070 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
0.2 1.1 GO:1990481 mRNA pseudouridine synthesis(GO:1990481)
0.2 0.5 GO:0007525 somatic muscle development(GO:0007525)
0.2 5.0 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.2 1.1 GO:0030242 pexophagy(GO:0030242)
0.2 2.5 GO:1902170 cellular response to reactive nitrogen species(GO:1902170)
0.2 3.5 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.2 0.8 GO:0060242 contact inhibition(GO:0060242)
0.1 0.4 GO:0032058 positive regulation of translational initiation in response to stress(GO:0032058)
0.1 0.6 GO:0042796 snRNA transcription from RNA polymerase III promoter(GO:0042796)
0.1 0.6 GO:0006014 D-ribose metabolic process(GO:0006014)
0.1 0.5 GO:0035087 siRNA loading onto RISC involved in RNA interference(GO:0035087)
0.1 0.3 GO:0009174 UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.1 2.2 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.1 0.5 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.1 2.0 GO:0090161 Golgi ribbon formation(GO:0090161)
0.1 0.7 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.1 0.8 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.1 0.6 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.1 0.4 GO:0090245 axis elongation involved in somitogenesis(GO:0090245)
0.1 0.4 GO:0090168 Golgi reassembly(GO:0090168)
0.1 0.3 GO:0018199 peptidyl-glutamine modification(GO:0018199)
0.1 0.3 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.1 1.3 GO:1904707 positive regulation of vascular smooth muscle cell proliferation(GO:1904707)
0.1 2.6 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1 1.4 GO:0006491 N-glycan processing(GO:0006491)
0.1 0.3 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.1 1.4 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.1 0.8 GO:0007602 phototransduction(GO:0007602)
0.0 0.4 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
0.0 0.6 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 1.2 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.0 1.1 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.0 0.1 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.0 1.6 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.7 GO:0060009 Sertoli cell development(GO:0060009)
0.0 0.7 GO:0072337 modified amino acid transport(GO:0072337)
0.0 2.7 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 0.9 GO:0045725 positive regulation of glycogen biosynthetic process(GO:0045725)
0.0 1.5 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.0 1.3 GO:0007606 sensory perception of chemical stimulus(GO:0007606)
0.0 1.3 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 0.4 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 3.8 GO:0006275 regulation of DNA replication(GO:0006275)
0.0 0.4 GO:0045943 positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.0 1.2 GO:0017156 calcium ion regulated exocytosis(GO:0017156)
0.0 2.2 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.0 0.2 GO:0044804 nucleophagy(GO:0044804)
0.0 0.2 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.2 GO:0009072 aromatic amino acid family metabolic process(GO:0009072)
0.0 1.0 GO:0007601 visual perception(GO:0007601)
0.0 0.1 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.3 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.3 1.5 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.3 0.9 GO:0005899 insulin receptor complex(GO:0005899)
0.3 1.8 GO:0001940 male pronucleus(GO:0001940)
0.3 0.8 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.2 2.7 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.2 5.5 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.1 0.4 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.1 1.5 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 2.6 GO:0005865 striated muscle thin filament(GO:0005865)
0.1 2.7 GO:0043194 axon initial segment(GO:0043194)
0.1 0.6 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.1 0.7 GO:0061574 ASAP complex(GO:0061574)
0.1 1.0 GO:0005922 connexon complex(GO:0005922)
0.1 1.9 GO:0000242 pericentriolar material(GO:0000242)
0.1 4.7 GO:0005882 intermediate filament(GO:0005882)
0.1 6.4 GO:0072562 blood microparticle(GO:0072562)
0.1 0.6 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.1 1.4 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 1.1 GO:0016460 myosin II complex(GO:0016460)
0.1 1.1 GO:0035253 ciliary rootlet(GO:0035253)
0.1 0.5 GO:0070578 RISC-loading complex(GO:0070578)
0.0 0.1 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.0 0.7 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 1.5 GO:0031201 SNARE complex(GO:0031201)
0.0 1.0 GO:0030673 axolemma(GO:0030673)
0.0 3.1 GO:0000922 spindle pole(GO:0000922)
0.0 0.8 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 3.7 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 1.4 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 0.7 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.6 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 1.9 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.6 GO:1990391 DNA repair complex(GO:1990391)
0.0 0.4 GO:0016592 mediator complex(GO:0016592)
0.0 3.8 GO:0016607 nuclear speck(GO:0016607)
0.0 1.0 GO:0016605 PML body(GO:0016605)
0.0 3.3 GO:0015629 actin cytoskeleton(GO:0015629)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.4 GO:0043682 copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682)
0.7 2.0 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.6 3.8 GO:0000213 tRNA-intron endonuclease activity(GO:0000213) endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.6 5.0 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.6 3.6 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.4 2.2 GO:0004342 glucosamine-6-phosphate deaminase activity(GO:0004342)
0.3 2.7 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.3 2.6 GO:0005523 tropomyosin binding(GO:0005523)
0.2 1.3 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.2 4.6 GO:0008327 methyl-CpG binding(GO:0008327)
0.2 3.5 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.2 0.7 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.2 0.7 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.2 1.1 GO:0099609 microtubule lateral binding(GO:0099609)
0.2 1.4 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.1 3.6 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 3.9 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.1 1.1 GO:0048406 nerve growth factor binding(GO:0048406)
0.1 0.6 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.1 0.5 GO:0035197 siRNA binding(GO:0035197)
0.1 1.8 GO:0001848 complement binding(GO:0001848)
0.1 0.6 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 0.4 GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599)
0.1 0.2 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.1 2.6 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 0.8 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.1 0.4 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.4 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.1 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 0.5 GO:0017166 vinculin binding(GO:0017166)
0.0 0.6 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 1.1 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 2.2 GO:0017022 myosin binding(GO:0017022)
0.0 0.7 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.4 GO:0000182 rDNA binding(GO:0000182)
0.0 0.9 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.8 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.7 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 1.1 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 1.0 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.4 GO:0043022 ribosome binding(GO:0043022)
0.0 1.7 GO:0019894 kinesin binding(GO:0019894)
0.0 1.1 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.3 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.0 0.5 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.3 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.0 0.8 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.2 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.6 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.3 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 0.2 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 0.3 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 1.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.4 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.0 0.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 8.3 GO:0008270 zinc ion binding(GO:0008270)
0.0 1.2 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.4 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 0.5 GO:0004896 cytokine receptor activity(GO:0004896)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.9 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 0.8 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.1 3.6 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.1 2.7 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.9 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 1.1 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 1.4 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.0 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 0.9 PID_INSULIN_PATHWAY Insulin Pathway
0.0 0.4 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.8 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 0.6 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.8 PID_PLK1_PATHWAY PLK1 signaling events
0.0 2.0 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.1 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 0.8 PID_E2F_PATHWAY E2F transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.8 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.2 2.7 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.2 0.8 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.1 4.4 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.1 1.1 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 1.1 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 4.4 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 1.0 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 2.6 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 1.0 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.1 1.1 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 3.6 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 1.1 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 1.2 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.9 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.9 REACTOME_MUSCLE_CONTRACTION Genes involved in Muscle contraction
0.0 0.8 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 1.9 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.4 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 1.7 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 0.4 REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER Genes involved in Formation of incision complex in GG-NER
0.0 0.7 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 1.1 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.1 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex