Motif ID: Nanog
Z-value: 0.554

Transcription factors associated with Nanog:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Nanog | ENSMUSG00000012396.6 | Nanog |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Nanog | mm10_v2_chr6_+_122707489_122707608 | 0.18 | 2.6e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.9 | 3.5 | GO:2000974 | negative regulation of pro-B cell differentiation(GO:2000974) |
0.5 | 1.6 | GO:0071918 | urea transmembrane transport(GO:0071918) |
0.3 | 1.6 | GO:2000346 | negative regulation of hepatocyte proliferation(GO:2000346) |
0.2 | 1.5 | GO:1902998 | macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
0.2 | 1.9 | GO:0071557 | histone H3-K27 demethylation(GO:0071557) |
0.2 | 0.7 | GO:0072092 | ureteric bud invasion(GO:0072092) |
0.2 | 0.5 | GO:0006553 | lysine metabolic process(GO:0006553) |
0.2 | 0.8 | GO:0021764 | amygdala development(GO:0021764) |
0.1 | 0.8 | GO:0043654 | skeletal muscle satellite cell activation(GO:0014719) recognition of apoptotic cell(GO:0043654) |
0.1 | 0.5 | GO:1904565 | response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566) |
0.1 | 0.5 | GO:2001032 | regulation of double-strand break repair via nonhomologous end joining(GO:2001032) |
0.1 | 0.3 | GO:0030862 | neuroblast division in subventricular zone(GO:0021849) positive regulation of polarized epithelial cell differentiation(GO:0030862) |
0.1 | 0.3 | GO:0002678 | positive regulation of chronic inflammatory response(GO:0002678) |
0.1 | 0.6 | GO:0021780 | oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780) |
0.1 | 0.4 | GO:0071596 | ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596) |
0.1 | 0.3 | GO:0070671 | monocyte extravasation(GO:0035696) activation of meiosis involved in egg activation(GO:0060466) response to interleukin-12(GO:0070671) positive regulation of acrosome reaction(GO:2000344) regulation of monocyte extravasation(GO:2000437) |
0.1 | 0.4 | GO:0010025 | wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166) |
0.1 | 1.4 | GO:0022027 | interkinetic nuclear migration(GO:0022027) |
0.1 | 0.6 | GO:1904177 | regulation of adipose tissue development(GO:1904177) |
0.1 | 0.6 | GO:0016127 | cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127) |
0.1 | 0.4 | GO:0006361 | transcription initiation from RNA polymerase I promoter(GO:0006361) termination of RNA polymerase I transcription(GO:0006363) |
0.1 | 0.3 | GO:0021564 | glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564) |
0.1 | 0.3 | GO:1900122 | positive regulation of receptor binding(GO:1900122) |
0.1 | 0.2 | GO:0034384 | complement receptor mediated signaling pathway(GO:0002430) GPI anchor release(GO:0006507) high-density lipoprotein particle clearance(GO:0034384) |
0.1 | 0.3 | GO:0098735 | cellular response to caffeine(GO:0071313) positive regulation of the force of heart contraction(GO:0098735) |
0.1 | 0.2 | GO:0006742 | NADP catabolic process(GO:0006742) pyridine nucleotide catabolic process(GO:0019364) |
0.1 | 0.3 | GO:0035989 | tendon development(GO:0035989) |
0.1 | 0.4 | GO:0030174 | regulation of DNA-dependent DNA replication initiation(GO:0030174) |
0.1 | 0.6 | GO:0035520 | monoubiquitinated protein deubiquitination(GO:0035520) |
0.0 | 0.5 | GO:0033601 | positive regulation of mammary gland epithelial cell proliferation(GO:0033601) |
0.0 | 0.5 | GO:0014883 | transition between fast and slow fiber(GO:0014883) |
0.0 | 0.3 | GO:0000707 | meiotic DNA recombinase assembly(GO:0000707) |
0.0 | 0.2 | GO:1905150 | regulation of voltage-gated sodium channel activity(GO:1905150) |
0.0 | 0.3 | GO:0061038 | negative regulation of acute inflammatory response(GO:0002674) uterus morphogenesis(GO:0061038) |
0.0 | 0.3 | GO:2000301 | negative regulation of synaptic vesicle exocytosis(GO:2000301) |
0.0 | 0.1 | GO:0001978 | regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback(GO:0001978) |
0.0 | 0.2 | GO:0042360 | vitamin E metabolic process(GO:0042360) |
0.0 | 0.1 | GO:1904742 | regulation of telomeric DNA binding(GO:1904742) |
0.0 | 0.3 | GO:0006686 | sphingomyelin biosynthetic process(GO:0006686) |
0.0 | 0.2 | GO:0010991 | negative regulation of SMAD protein complex assembly(GO:0010991) |
0.0 | 0.3 | GO:1900262 | regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264) |
0.0 | 0.2 | GO:1903056 | positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056) |
0.0 | 0.1 | GO:0045113 | integrin biosynthetic process(GO:0045112) regulation of integrin biosynthetic process(GO:0045113) |
0.0 | 0.3 | GO:0061002 | negative regulation of dendritic spine morphogenesis(GO:0061002) |
0.0 | 0.1 | GO:0070649 | meiotic chromosome movement towards spindle pole(GO:0016344) formin-nucleated actin cable assembly(GO:0070649) |
0.0 | 0.1 | GO:1902260 | negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817) |
0.0 | 0.4 | GO:0002230 | positive regulation of defense response to virus by host(GO:0002230) |
0.0 | 0.1 | GO:1902261 | positive regulation of delayed rectifier potassium channel activity(GO:1902261) |
0.0 | 0.1 | GO:1904749 | regulation of protein localization to nucleolus(GO:1904749) |
0.0 | 0.5 | GO:0060009 | Sertoli cell development(GO:0060009) |
0.0 | 0.2 | GO:0018243 | protein O-linked glycosylation via threonine(GO:0018243) |
0.0 | 0.2 | GO:0019065 | receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509) |
0.0 | 0.2 | GO:0097118 | neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118) |
0.0 | 0.1 | GO:1904207 | chemokine (C-C motif) ligand 2 secretion(GO:0035926) regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209) |
0.0 | 0.1 | GO:0097646 | calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647) |
0.0 | 0.5 | GO:0002091 | negative regulation of receptor internalization(GO:0002091) |
0.0 | 0.4 | GO:0051131 | chaperone-mediated protein complex assembly(GO:0051131) |
0.0 | 0.1 | GO:0044027 | hypermethylation of CpG island(GO:0044027) |
0.0 | 0.8 | GO:0007212 | dopamine receptor signaling pathway(GO:0007212) |
0.0 | 0.4 | GO:2000651 | positive regulation of sodium ion transmembrane transporter activity(GO:2000651) |
0.0 | 0.2 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
0.0 | 0.2 | GO:0034242 | negative regulation of syncytium formation by plasma membrane fusion(GO:0034242) |
0.0 | 0.4 | GO:0001886 | endothelial cell morphogenesis(GO:0001886) |
0.0 | 0.4 | GO:1902043 | positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043) |
0.0 | 0.3 | GO:0035721 | intraciliary retrograde transport(GO:0035721) |
0.0 | 0.2 | GO:0071732 | cellular response to nitric oxide(GO:0071732) |
0.0 | 0.4 | GO:0007608 | sensory perception of smell(GO:0007608) |
0.0 | 0.3 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
0.0 | 0.0 | GO:2000642 | negative regulation of early endosome to late endosome transport(GO:2000642) |
0.0 | 0.1 | GO:1900220 | semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220) |
0.0 | 0.3 | GO:0008340 | determination of adult lifespan(GO:0008340) |
0.0 | 0.1 | GO:0017196 | N-terminal peptidyl-methionine acetylation(GO:0017196) |
0.0 | 0.3 | GO:0045736 | negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030) |
0.0 | 0.6 | GO:0046329 | negative regulation of JNK cascade(GO:0046329) |
0.0 | 0.0 | GO:0042713 | negative regulation of urine volume(GO:0035811) sperm ejaculation(GO:0042713) negative regulation of gastric acid secretion(GO:0060455) |
0.0 | 0.1 | GO:0045876 | positive regulation of sister chromatid cohesion(GO:0045876) |
0.0 | 0.7 | GO:0038083 | peptidyl-tyrosine autophosphorylation(GO:0038083) |
0.0 | 0.0 | GO:0061300 | cerebellum vasculature development(GO:0061300) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 1.5 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
0.1 | 0.5 | GO:0071148 | TEAD-1-YAP complex(GO:0071148) |
0.1 | 0.2 | GO:0000801 | central element(GO:0000801) |
0.1 | 0.6 | GO:0042587 | glycogen granule(GO:0042587) |
0.1 | 0.3 | GO:0033063 | Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063) |
0.0 | 1.0 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
0.0 | 0.8 | GO:0001891 | phagocytic cup(GO:0001891) |
0.0 | 0.3 | GO:0000138 | Golgi trans cisterna(GO:0000138) |
0.0 | 0.3 | GO:0031390 | Ctf18 RFC-like complex(GO:0031390) |
0.0 | 0.4 | GO:0042405 | nuclear inclusion body(GO:0042405) |
0.0 | 0.6 | GO:0071004 | U2-type prespliceosome(GO:0071004) |
0.0 | 0.3 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
0.0 | 0.3 | GO:0005832 | chaperonin-containing T-complex(GO:0005832) |
0.0 | 0.8 | GO:0001917 | photoreceptor inner segment(GO:0001917) |
0.0 | 0.2 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
0.0 | 0.2 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
0.0 | 0.8 | GO:0016235 | aggresome(GO:0016235) |
0.0 | 0.3 | GO:0005614 | interstitial matrix(GO:0005614) |
0.0 | 0.2 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
0.0 | 0.1 | GO:0000798 | nuclear cohesin complex(GO:0000798) |
0.0 | 0.4 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) |
0.0 | 0.1 | GO:0045298 | tubulin complex(GO:0045298) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 1.9 | GO:0071558 | histone demethylase activity (H3-K27 specific)(GO:0071558) |
0.3 | 1.6 | GO:0015204 | urea transmembrane transporter activity(GO:0015204) |
0.2 | 0.6 | GO:0052740 | phosphatidylserine 1-acylhydrolase activity(GO:0052739) 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740) |
0.1 | 0.8 | GO:0001849 | complement component C1q binding(GO:0001849) |
0.1 | 0.3 | GO:0047256 | beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256) |
0.1 | 0.4 | GO:0032027 | myosin light chain binding(GO:0032027) |
0.1 | 0.6 | GO:0070915 | lysophosphatidic acid receptor activity(GO:0070915) |
0.1 | 0.4 | GO:0080019 | fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019) |
0.1 | 0.3 | GO:0086038 | calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038) |
0.1 | 0.4 | GO:0003828 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828) |
0.1 | 1.5 | GO:0051787 | misfolded protein binding(GO:0051787) |
0.1 | 0.3 | GO:0033188 | sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493) |
0.1 | 0.4 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
0.1 | 0.2 | GO:0035529 | NADH pyrophosphatase activity(GO:0035529) |
0.1 | 0.3 | GO:0046975 | histone methyltransferase activity (H3-K36 specific)(GO:0046975) |
0.1 | 0.4 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
0.1 | 0.4 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
0.0 | 0.5 | GO:0001134 | transcription factor activity, transcription factor recruiting(GO:0001134) |
0.0 | 0.3 | GO:0004984 | olfactory receptor activity(GO:0004984) |
0.0 | 0.3 | GO:0000150 | recombinase activity(GO:0000150) |
0.0 | 0.3 | GO:0001609 | G-protein coupled adenosine receptor activity(GO:0001609) |
0.0 | 6.2 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
0.0 | 0.2 | GO:0070699 | type II activin receptor binding(GO:0070699) |
0.0 | 0.1 | GO:0008172 | S-methyltransferase activity(GO:0008172) |
0.0 | 0.5 | GO:0042043 | neurexin family protein binding(GO:0042043) |
0.0 | 0.6 | GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) |
0.0 | 0.3 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
0.0 | 0.3 | GO:0003689 | DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) |
0.0 | 0.3 | GO:0045294 | alpha-catenin binding(GO:0045294) |
0.0 | 0.1 | GO:0004118 | cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) |
0.0 | 0.5 | GO:0016646 | oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646) |
0.0 | 0.3 | GO:0008484 | sulfuric ester hydrolase activity(GO:0008484) |
0.0 | 0.2 | GO:0004630 | phospholipase D activity(GO:0004630) |
0.0 | 0.1 | GO:0005432 | calcium:sodium antiporter activity(GO:0005432) calcium, potassium:sodium antiporter activity(GO:0008273) |
0.0 | 0.3 | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) |
0.0 | 0.7 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
0.0 | 0.7 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
0.0 | 0.3 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
0.0 | 0.0 | GO:0043758 | acetate-CoA ligase (ADP-forming) activity(GO:0043758) |
0.0 | 0.1 | GO:0003886 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) |
0.0 | 0.3 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
0.0 | 0.1 | GO:0015643 | toxic substance binding(GO:0015643) |
0.0 | 0.3 | GO:0043422 | protein kinase B binding(GO:0043422) |
0.0 | 0.3 | GO:0005521 | lamin binding(GO:0005521) |
0.0 | 0.3 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
0.0 | 1.0 | GO:0002039 | p53 binding(GO:0002039) |
0.0 | 0.3 | GO:0001968 | fibronectin binding(GO:0001968) |
0.0 | 0.0 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
0.0 | 0.2 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 0.8 | PID_RHODOPSIN_PATHWAY | Visual signal transduction: Rods |
0.0 | 2.8 | PID_ILK_PATHWAY | Integrin-linked kinase signaling |
0.0 | 4.3 | PID_CDC42_PATHWAY | CDC42 signaling events |
0.0 | 1.3 | NABA_COLLAGENS | Genes encoding collagen proteins |
0.0 | 0.4 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
0.0 | 0.2 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
0.0 | 0.3 | PID_AR_NONGENOMIC_PATHWAY | Nongenotropic Androgen signaling |
0.0 | 0.4 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
0.0 | 0.3 | PID_SYNDECAN_1_PATHWAY | Syndecan-1-mediated signaling events |
0.0 | 1.2 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
0.0 | 0.8 | PID_TRKR_PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
0.0 | 0.7 | PID_FAK_PATHWAY | Signaling events mediated by focal adhesion kinase |
0.0 | 0.3 | PID_IL2_PI3K_PATHWAY | IL2 signaling events mediated by PI3K |
0.0 | 0.5 | PID_AURORA_B_PATHWAY | Aurora B signaling |
0.0 | 0.2 | PID_UPA_UPAR_PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
0.0 | 0.5 | PID_LYSOPHOSPHOLIPID_PATHWAY | LPA receptor mediated events |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 0.6 | REACTOME_ENDOGENOUS_STEROLS | Genes involved in Endogenous sterols |
0.1 | 1.5 | REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS | Genes involved in Amine compound SLC transporters |
0.1 | 0.6 | REACTOME_ACYL_CHAIN_REMODELLING_OF_PI | Genes involved in Acyl chain remodelling of PI |
0.1 | 1.6 | REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
0.0 | 0.4 | REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
0.0 | 3.5 | REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
0.0 | 0.4 | REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
0.0 | 0.8 | REACTOME_SIGNAL_ATTENUATION | Genes involved in Signal attenuation |
0.0 | 0.3 | REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
0.0 | 0.3 | REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS | Genes involved in Nucleotide-like (purinergic) receptors |
0.0 | 1.3 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
0.0 | 0.3 | REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION | Genes involved in Extracellular matrix organization |
0.0 | 0.5 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
0.0 | 0.3 | REACTOME_PLATELET_CALCIUM_HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
0.0 | 0.2 | REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING | Genes involved in Spry regulation of FGF signaling |
0.0 | 0.3 | REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
0.0 | 0.2 | REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
0.0 | 0.1 | REACTOME_ACETYLCHOLINE_BINDING_AND_DOWNSTREAM_EVENTS | Genes involved in Acetylcholine Binding And Downstream Events |
0.0 | 0.4 | REACTOME_PEROXISOMAL_LIPID_METABOLISM | Genes involved in Peroxisomal lipid metabolism |
0.0 | 0.4 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
0.0 | 1.0 | REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ | Genes involved in Response to elevated platelet cytosolic Ca2+ |
0.0 | 0.4 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |