Motif ID: Rfx3_Rfx1_Rfx4
Z-value: 2.661



Transcription factors associated with Rfx3_Rfx1_Rfx4:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Rfx1 | ENSMUSG00000031706.6 | Rfx1 |
Rfx3 | ENSMUSG00000040929.10 | Rfx3 |
Rfx4 | ENSMUSG00000020037.9 | Rfx4 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Rfx1 | mm10_v2_chr8_+_84066824_84066882 | -0.32 | 4.1e-02 | Click! |
Rfx4 | mm10_v2_chr10_+_84838143_84838153 | -0.31 | 4.6e-02 | Click! |
Rfx3 | mm10_v2_chr19_-_28010995_28011054 | 0.04 | 8.2e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
4.1 | 52.7 | GO:0099628 | receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628) |
3.0 | 14.8 | GO:2000325 | regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327) |
1.7 | 7.0 | GO:0002924 | negative regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002924) negative regulation of interleukin-6 biosynthetic process(GO:0045409) |
1.6 | 12.9 | GO:0021937 | cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation(GO:0021937) |
1.6 | 4.8 | GO:2000836 | negative regulation of glucagon secretion(GO:0070093) positive regulation of androgen secretion(GO:2000836) positive regulation of testosterone secretion(GO:2000845) |
1.5 | 6.1 | GO:0030860 | regulation of polarized epithelial cell differentiation(GO:0030860) |
1.4 | 4.2 | GO:1990523 | negative regulation of SMAD protein import into nucleus(GO:0060392) endothelial cell-cell adhesion(GO:0071603) bone regeneration(GO:1990523) |
1.4 | 12.5 | GO:0048170 | positive regulation of long-term neuronal synaptic plasticity(GO:0048170) |
1.2 | 4.8 | GO:0032914 | positive regulation of transforming growth factor beta1 production(GO:0032914) |
1.2 | 4.7 | GO:1903031 | regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033) |
1.0 | 6.8 | GO:0035093 | spermatogenesis, exchange of chromosomal proteins(GO:0035093) |
0.9 | 3.7 | GO:0042360 | vitamin E metabolic process(GO:0042360) |
0.9 | 2.6 | GO:0016598 | protein arginylation(GO:0016598) |
0.9 | 1.7 | GO:0009826 | unidimensional cell growth(GO:0009826) |
0.8 | 3.4 | GO:0060316 | positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316) |
0.8 | 4.9 | GO:0045218 | zonula adherens maintenance(GO:0045218) |
0.8 | 2.3 | GO:0006532 | aspartate biosynthetic process(GO:0006532) |
0.8 | 21.8 | GO:0048268 | clathrin coat assembly(GO:0048268) |
0.7 | 2.2 | GO:0090285 | negative regulation of protein glycosylation in Golgi(GO:0090285) |
0.7 | 12.8 | GO:0016486 | peptide hormone processing(GO:0016486) |
0.7 | 2.0 | GO:0071963 | establishment or maintenance of cell polarity regulating cell shape(GO:0071963) |
0.6 | 3.8 | GO:0007258 | JUN phosphorylation(GO:0007258) |
0.6 | 13.0 | GO:0045063 | T-helper 1 cell differentiation(GO:0045063) |
0.5 | 2.4 | GO:1902412 | regulation of mitotic cytokinesis(GO:1902412) |
0.5 | 5.3 | GO:2000580 | positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582) |
0.5 | 2.9 | GO:2000210 | positive regulation of anoikis(GO:2000210) |
0.4 | 1.8 | GO:1904457 | positive regulation of neuronal action potential(GO:1904457) |
0.4 | 2.2 | GO:0043314 | negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313) |
0.4 | 3.1 | GO:0061002 | negative regulation of dendritic spine morphogenesis(GO:0061002) |
0.4 | 9.2 | GO:0071625 | vocalization behavior(GO:0071625) |
0.4 | 1.7 | GO:2001137 | positive regulation of endocytic recycling(GO:2001137) |
0.4 | 9.7 | GO:0099517 | anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517) |
0.4 | 1.6 | GO:0070317 | negative regulation of G0 to G1 transition(GO:0070317) |
0.4 | 6.1 | GO:2000042 | negative regulation of double-strand break repair via homologous recombination(GO:2000042) |
0.4 | 4.7 | GO:0051823 | radial glia guided migration of Purkinje cell(GO:0021942) regulation of synapse structural plasticity(GO:0051823) |
0.4 | 3.0 | GO:0003356 | regulation of cilium movement(GO:0003352) regulation of cilium beat frequency(GO:0003356) |
0.4 | 0.7 | GO:1900126 | negative regulation of hyaluronan biosynthetic process(GO:1900126) |
0.4 | 2.2 | GO:2000304 | positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304) |
0.3 | 15.4 | GO:0007026 | negative regulation of microtubule depolymerization(GO:0007026) |
0.3 | 4.8 | GO:0021684 | cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707) |
0.3 | 5.1 | GO:0007220 | Notch receptor processing(GO:0007220) |
0.3 | 3.8 | GO:2001269 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269) |
0.3 | 1.3 | GO:1902202 | regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202) negative regulation of PERK-mediated unfolded protein response(GO:1903898) |
0.3 | 1.5 | GO:0032423 | regulation of mismatch repair(GO:0032423) |
0.3 | 4.8 | GO:0035414 | negative regulation of catenin import into nucleus(GO:0035414) |
0.3 | 0.9 | GO:1903070 | negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070) |
0.3 | 2.7 | GO:0036371 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
0.3 | 1.7 | GO:0035435 | phosphate ion transmembrane transport(GO:0035435) |
0.3 | 0.6 | GO:1903527 | regulation of membrane tubulation(GO:1903525) positive regulation of membrane tubulation(GO:1903527) |
0.3 | 1.4 | GO:0090038 | negative regulation of protein kinase C signaling(GO:0090038) |
0.3 | 0.8 | GO:1903984 | positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984) negative regulation of metalloendopeptidase activity(GO:1904684) |
0.3 | 1.9 | GO:0034145 | positive regulation of toll-like receptor 4 signaling pathway(GO:0034145) |
0.3 | 6.9 | GO:0032011 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
0.3 | 1.0 | GO:1901475 | pyruvate transmembrane transport(GO:1901475) |
0.3 | 0.8 | GO:0008626 | granzyme-mediated apoptotic signaling pathway(GO:0008626) |
0.3 | 2.5 | GO:0021678 | third ventricle development(GO:0021678) |
0.3 | 6.3 | GO:0060074 | synapse maturation(GO:0060074) |
0.3 | 14.5 | GO:2000649 | regulation of sodium ion transmembrane transporter activity(GO:2000649) |
0.2 | 1.7 | GO:0002318 | myeloid progenitor cell differentiation(GO:0002318) |
0.2 | 2.8 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
0.2 | 1.1 | GO:0090063 | positive regulation of microtubule nucleation(GO:0090063) |
0.2 | 0.9 | GO:1902237 | positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902237) |
0.2 | 0.2 | GO:2000331 | regulation of terminal button organization(GO:2000331) |
0.2 | 18.7 | GO:0022900 | electron transport chain(GO:0022900) |
0.2 | 0.7 | GO:0070649 | formin-nucleated actin cable assembly(GO:0070649) |
0.2 | 3.7 | GO:0000338 | protein deneddylation(GO:0000338) |
0.2 | 6.3 | GO:2000171 | negative regulation of dendrite development(GO:2000171) |
0.2 | 3.2 | GO:0071801 | regulation of podosome assembly(GO:0071801) |
0.2 | 1.7 | GO:0060294 | cilium movement involved in cell motility(GO:0060294) |
0.2 | 1.7 | GO:0000395 | mRNA 5'-splice site recognition(GO:0000395) |
0.2 | 1.0 | GO:0031914 | negative regulation of synaptic plasticity(GO:0031914) |
0.2 | 0.6 | GO:0018094 | protein polyglycylation(GO:0018094) |
0.2 | 2.8 | GO:0007340 | acrosome reaction(GO:0007340) |
0.2 | 6.8 | GO:0007189 | adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189) |
0.2 | 1.1 | GO:0006172 | ADP biosynthetic process(GO:0006172) |
0.2 | 0.7 | GO:0010288 | response to lead ion(GO:0010288) |
0.2 | 4.2 | GO:0097320 | membrane tubulation(GO:0097320) |
0.2 | 10.2 | GO:0032418 | lysosome localization(GO:0032418) |
0.2 | 0.5 | GO:0031660 | regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662) |
0.2 | 2.0 | GO:0090503 | RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503) |
0.2 | 1.4 | GO:0071557 | histone H3-K27 demethylation(GO:0071557) |
0.2 | 1.2 | GO:0099590 | neurotransmitter receptor internalization(GO:0099590) |
0.2 | 2.4 | GO:0071712 | ER-associated misfolded protein catabolic process(GO:0071712) |
0.2 | 0.6 | GO:1902260 | negative regulation of delayed rectifier potassium channel activity(GO:1902260) |
0.2 | 4.2 | GO:0010107 | potassium ion import(GO:0010107) |
0.2 | 2.0 | GO:0006654 | phosphatidic acid biosynthetic process(GO:0006654) |
0.2 | 0.3 | GO:1902953 | positive regulation of ER to Golgi vesicle-mediated transport(GO:1902953) |
0.2 | 1.5 | GO:0007288 | sperm axoneme assembly(GO:0007288) |
0.2 | 1.8 | GO:0043508 | negative regulation of JUN kinase activity(GO:0043508) |
0.2 | 0.9 | GO:0048102 | autophagic cell death(GO:0048102) |
0.2 | 2.0 | GO:0035881 | amacrine cell differentiation(GO:0035881) retinal rod cell development(GO:0046548) |
0.2 | 0.8 | GO:0051684 | maintenance of Golgi location(GO:0051684) |
0.2 | 0.3 | GO:0075136 | response to defenses of other organism involved in symbiotic interaction(GO:0052173) response to host defenses(GO:0052200) response to host(GO:0075136) |
0.2 | 0.5 | GO:0045041 | protein import into mitochondrial intermembrane space(GO:0045041) |
0.1 | 1.6 | GO:0048672 | positive regulation of collateral sprouting(GO:0048672) |
0.1 | 1.7 | GO:0099500 | synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500) |
0.1 | 5.1 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
0.1 | 2.5 | GO:0002115 | store-operated calcium entry(GO:0002115) |
0.1 | 1.3 | GO:0000042 | protein targeting to Golgi(GO:0000042) |
0.1 | 3.8 | GO:0002437 | inflammatory response to antigenic stimulus(GO:0002437) |
0.1 | 0.6 | GO:1904425 | regulation of microvillus assembly(GO:0032534) negative regulation of GTP binding(GO:1904425) |
0.1 | 0.8 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
0.1 | 1.3 | GO:1900017 | positive regulation of cytokine production involved in inflammatory response(GO:1900017) |
0.1 | 2.5 | GO:0034308 | primary alcohol metabolic process(GO:0034308) |
0.1 | 0.8 | GO:0060267 | positive regulation of respiratory burst(GO:0060267) |
0.1 | 0.9 | GO:0032790 | ribosome disassembly(GO:0032790) |
0.1 | 6.3 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
0.1 | 0.9 | GO:1990845 | adaptive thermogenesis(GO:1990845) |
0.1 | 0.7 | GO:0032782 | bile acid secretion(GO:0032782) |
0.1 | 4.4 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
0.1 | 0.7 | GO:0034983 | peptidyl-lysine deacetylation(GO:0034983) |
0.1 | 0.2 | GO:0072553 | terminal button organization(GO:0072553) |
0.1 | 0.4 | GO:0030277 | maintenance of gastrointestinal epithelium(GO:0030277) |
0.1 | 0.5 | GO:1903553 | positive regulation of extracellular exosome assembly(GO:1903553) |
0.1 | 9.5 | GO:0007286 | spermatid development(GO:0007286) |
0.1 | 1.3 | GO:0051639 | actin filament network formation(GO:0051639) |
0.1 | 1.3 | GO:2000300 | regulation of synaptic vesicle exocytosis(GO:2000300) |
0.1 | 0.8 | GO:0090148 | membrane fission(GO:0090148) |
0.1 | 0.6 | GO:0035735 | intraciliary transport involved in cilium morphogenesis(GO:0035735) |
0.1 | 1.2 | GO:0070389 | chaperone cofactor-dependent protein refolding(GO:0070389) |
0.1 | 0.3 | GO:0052490 | suppression by virus of host apoptotic process(GO:0019050) negative regulation by symbiont of host apoptotic process(GO:0033668) modulation by virus of host apoptotic process(GO:0039526) negative regulation by symbiont of host programmed cell death(GO:0052041) negative regulation by organism of programmed cell death in other organism involved in symbiotic interaction(GO:0052490) positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902220) |
0.1 | 1.2 | GO:0021869 | forebrain ventricular zone progenitor cell division(GO:0021869) |
0.1 | 2.7 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
0.1 | 0.4 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
0.1 | 0.5 | GO:0030913 | paranodal junction assembly(GO:0030913) |
0.1 | 2.4 | GO:0071158 | positive regulation of cell cycle arrest(GO:0071158) |
0.1 | 3.3 | GO:0031122 | cytoplasmic microtubule organization(GO:0031122) |
0.1 | 0.6 | GO:0001539 | cilium or flagellum-dependent cell motility(GO:0001539) cilium-dependent cell motility(GO:0060285) |
0.1 | 0.6 | GO:0018026 | peptidyl-lysine monomethylation(GO:0018026) |
0.1 | 1.8 | GO:0071480 | cellular response to gamma radiation(GO:0071480) |
0.1 | 5.2 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
0.1 | 2.0 | GO:0045648 | positive regulation of erythrocyte differentiation(GO:0045648) |
0.1 | 3.9 | GO:0019226 | transmission of nerve impulse(GO:0019226) |
0.1 | 0.5 | GO:0070933 | histone H4 deacetylation(GO:0070933) |
0.1 | 1.7 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
0.1 | 0.3 | GO:0030382 | sperm mitochondrion organization(GO:0030382) |
0.1 | 2.3 | GO:1903078 | positive regulation of protein localization to plasma membrane(GO:1903078) |
0.1 | 0.4 | GO:1903441 | protein localization to ciliary membrane(GO:1903441) |
0.1 | 2.6 | GO:0007338 | single fertilization(GO:0007338) |
0.1 | 0.2 | GO:0045014 | carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) |
0.1 | 0.3 | GO:0061092 | detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962) regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092) |
0.1 | 1.2 | GO:0051457 | maintenance of protein location in nucleus(GO:0051457) |
0.1 | 0.3 | GO:0006616 | SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616) |
0.1 | 0.2 | GO:0006788 | heme oxidation(GO:0006788) |
0.1 | 1.2 | GO:0097120 | receptor localization to synapse(GO:0097120) |
0.1 | 7.0 | GO:0006626 | protein targeting to mitochondrion(GO:0006626) |
0.0 | 2.7 | GO:0060113 | inner ear receptor cell differentiation(GO:0060113) |
0.0 | 0.6 | GO:1904294 | positive regulation of ERAD pathway(GO:1904294) |
0.0 | 0.2 | GO:0007197 | adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207) |
0.0 | 0.5 | GO:0090110 | cargo loading into COPII-coated vesicle(GO:0090110) |
0.0 | 0.1 | GO:0043312 | neutrophil degranulation(GO:0043312) |
0.0 | 2.0 | GO:0034766 | negative regulation of ion transmembrane transport(GO:0034766) |
0.0 | 0.6 | GO:0009143 | nucleoside triphosphate catabolic process(GO:0009143) ribonucleoside diphosphate catabolic process(GO:0009191) |
0.0 | 0.4 | GO:0006398 | mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398) |
0.0 | 0.2 | GO:0033540 | fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540) |
0.0 | 0.4 | GO:0010793 | regulation of mRNA export from nucleus(GO:0010793) |
0.0 | 1.4 | GO:0048013 | ephrin receptor signaling pathway(GO:0048013) |
0.0 | 0.7 | GO:0002495 | antigen processing and presentation of peptide antigen via MHC class II(GO:0002495) antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504) |
0.0 | 0.4 | GO:0006465 | signal peptide processing(GO:0006465) |
0.0 | 1.4 | GO:0036075 | endochondral ossification(GO:0001958) replacement ossification(GO:0036075) |
0.0 | 0.7 | GO:0007608 | sensory perception of smell(GO:0007608) |
0.0 | 0.8 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
0.0 | 1.3 | GO:0007193 | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193) |
0.0 | 0.5 | GO:0070131 | positive regulation of mitochondrial translation(GO:0070131) |
0.0 | 0.5 | GO:0034389 | lipid particle organization(GO:0034389) |
0.0 | 0.2 | GO:0048793 | pronephros development(GO:0048793) |
0.0 | 0.6 | GO:0031573 | intra-S DNA damage checkpoint(GO:0031573) |
0.0 | 0.4 | GO:0070995 | NADPH oxidation(GO:0070995) |
0.0 | 0.1 | GO:0001193 | maintenance of transcriptional fidelity during DNA-templated transcription elongation(GO:0001192) maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter(GO:0001193) |
0.0 | 0.1 | GO:0090400 | stress-induced premature senescence(GO:0090400) |
0.0 | 1.5 | GO:0006284 | base-excision repair(GO:0006284) |
0.0 | 0.8 | GO:0035067 | negative regulation of histone acetylation(GO:0035067) |
0.0 | 0.1 | GO:0071930 | negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930) |
0.0 | 0.1 | GO:0006420 | arginyl-tRNA aminoacylation(GO:0006420) |
0.0 | 0.3 | GO:0009249 | protein lipoylation(GO:0009249) |
0.0 | 0.3 | GO:0061469 | regulation of type B pancreatic cell proliferation(GO:0061469) |
0.0 | 0.1 | GO:0051490 | negative regulation of filopodium assembly(GO:0051490) |
0.0 | 0.7 | GO:0045662 | negative regulation of myoblast differentiation(GO:0045662) |
0.0 | 0.1 | GO:0046947 | hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947) |
0.0 | 0.8 | GO:0000132 | establishment of mitotic spindle orientation(GO:0000132) |
0.0 | 0.5 | GO:0009566 | fertilization(GO:0009566) |
0.0 | 0.4 | GO:0043248 | proteasome assembly(GO:0043248) |
0.0 | 1.6 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
0.0 | 0.2 | GO:0071494 | cellular response to UV-C(GO:0071494) |
0.0 | 0.2 | GO:0006283 | transcription-coupled nucleotide-excision repair(GO:0006283) |
0.0 | 0.4 | GO:0007097 | nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023) |
0.0 | 1.1 | GO:0033209 | tumor necrosis factor-mediated signaling pathway(GO:0033209) |
0.0 | 1.0 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
0.0 | 1.8 | GO:0034446 | substrate adhesion-dependent cell spreading(GO:0034446) |
0.0 | 0.2 | GO:0039532 | negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway(GO:0039532) |
0.0 | 0.2 | GO:0046051 | UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051) |
0.0 | 0.2 | GO:2000786 | positive regulation of autophagosome assembly(GO:2000786) |
0.0 | 1.3 | GO:0045454 | cell redox homeostasis(GO:0045454) |
0.0 | 0.5 | GO:0051443 | positive regulation of ubiquitin-protein transferase activity(GO:0051443) |
0.0 | 0.1 | GO:1990022 | RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022) |
0.0 | 0.0 | GO:0060018 | astrocyte fate commitment(GO:0060018) |
0.0 | 0.4 | GO:0060716 | labyrinthine layer blood vessel development(GO:0060716) |
0.0 | 0.2 | GO:0090178 | establishment of planar polarity involved in neural tube closure(GO:0090177) regulation of establishment of planar polarity involved in neural tube closure(GO:0090178) planar cell polarity pathway involved in neural tube closure(GO:0090179) |
0.0 | 0.0 | GO:0009814 | defense response, incompatible interaction(GO:0009814) |
0.0 | 0.1 | GO:0046321 | positive regulation of fatty acid oxidation(GO:0046321) |
0.0 | 0.9 | GO:0030500 | regulation of bone mineralization(GO:0030500) |
0.0 | 0.1 | GO:0006685 | sphingomyelin catabolic process(GO:0006685) |
0.0 | 0.3 | GO:0006891 | intra-Golgi vesicle-mediated transport(GO:0006891) |
0.0 | 0.5 | GO:0045494 | photoreceptor cell maintenance(GO:0045494) |
0.0 | 0.3 | GO:0051447 | negative regulation of meiotic cell cycle(GO:0051447) |
0.0 | 0.1 | GO:0098700 | neurotransmitter loading into synaptic vesicle(GO:0098700) |
0.0 | 1.2 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
0.0 | 0.1 | GO:0006002 | fructose 6-phosphate metabolic process(GO:0006002) |
0.0 | 0.1 | GO:0071763 | nuclear membrane organization(GO:0071763) |
0.0 | 0.2 | GO:1903541 | regulation of exosomal secretion(GO:1903541) positive regulation of exosomal secretion(GO:1903543) |
0.0 | 1.1 | GO:0043149 | contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149) |
0.0 | 0.5 | GO:0006906 | vesicle fusion(GO:0006906) |
0.0 | 1.2 | GO:0010977 | negative regulation of neuron projection development(GO:0010977) |
0.0 | 0.4 | GO:0048168 | regulation of neuronal synaptic plasticity(GO:0048168) |
0.0 | 0.1 | GO:1904262 | negative regulation of TORC1 signaling(GO:1904262) |
0.0 | 0.5 | GO:0030032 | lamellipodium assembly(GO:0030032) |
0.0 | 0.7 | GO:0051453 | regulation of intracellular pH(GO:0051453) |
0.0 | 1.6 | GO:0008654 | phospholipid biosynthetic process(GO:0008654) |
0.0 | 0.1 | GO:0006020 | inositol metabolic process(GO:0006020) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
15.9 | 47.8 | GO:0099573 | glutamatergic postsynaptic density(GO:0099573) |
3.1 | 12.2 | GO:1990769 | proximal neuron projection(GO:1990769) |
1.6 | 6.2 | GO:0089717 | spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717) |
1.2 | 9.3 | GO:0001520 | outer dense fiber(GO:0001520) |
0.8 | 7.0 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
0.7 | 2.0 | GO:0016939 | kinesin II complex(GO:0016939) |
0.6 | 1.7 | GO:0020018 | ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018) |
0.5 | 2.2 | GO:0030121 | AP-1 adaptor complex(GO:0030121) |
0.5 | 7.6 | GO:1904115 | axon cytoplasm(GO:1904115) |
0.5 | 8.2 | GO:0005640 | nuclear outer membrane(GO:0005640) |
0.4 | 4.9 | GO:0005915 | zonula adherens(GO:0005915) |
0.4 | 4.8 | GO:0031258 | lamellipodium membrane(GO:0031258) |
0.4 | 2.4 | GO:0000235 | astral microtubule(GO:0000235) |
0.4 | 1.8 | GO:0044316 | cone cell pedicle(GO:0044316) |
0.3 | 4.8 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
0.3 | 0.3 | GO:0030981 | cortical microtubule cytoskeleton(GO:0030981) |
0.3 | 5.9 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
0.3 | 9.0 | GO:0035371 | microtubule plus-end(GO:0035371) |
0.3 | 0.3 | GO:0098830 | presynaptic endosome(GO:0098830) |
0.2 | 3.4 | GO:0030122 | AP-2 adaptor complex(GO:0030122) |
0.2 | 6.6 | GO:0034451 | centriolar satellite(GO:0034451) |
0.2 | 5.2 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
0.2 | 1.3 | GO:0097443 | sorting endosome(GO:0097443) |
0.2 | 8.4 | GO:0097546 | ciliary base(GO:0097546) |
0.2 | 2.2 | GO:0000137 | Golgi cis cisterna(GO:0000137) |
0.2 | 0.7 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
0.2 | 6.5 | GO:0035861 | site of double-strand break(GO:0035861) |
0.2 | 6.8 | GO:0097440 | apical dendrite(GO:0097440) |
0.2 | 1.7 | GO:0070852 | cell body fiber(GO:0070852) |
0.2 | 4.4 | GO:0030137 | COPI-coated vesicle(GO:0030137) |
0.2 | 2.3 | GO:0036513 | Derlin-1 retrotranslocation complex(GO:0036513) |
0.2 | 4.2 | GO:0005921 | gap junction(GO:0005921) |
0.2 | 3.1 | GO:0060170 | ciliary membrane(GO:0060170) |
0.2 | 1.1 | GO:0002177 | manchette(GO:0002177) |
0.2 | 2.0 | GO:0000177 | cytoplasmic exosome (RNase complex)(GO:0000177) |
0.1 | 1.6 | GO:0000812 | Swr1 complex(GO:0000812) |
0.1 | 11.7 | GO:0001669 | acrosomal vesicle(GO:0001669) |
0.1 | 7.0 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
0.1 | 0.8 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
0.1 | 0.7 | GO:0046581 | intercellular canaliculus(GO:0046581) |
0.1 | 1.3 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
0.1 | 3.9 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
0.1 | 6.1 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
0.1 | 23.8 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
0.1 | 0.5 | GO:0005683 | U7 snRNP(GO:0005683) |
0.1 | 1.5 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
0.1 | 4.4 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
0.1 | 0.6 | GO:0031314 | extrinsic component of mitochondrial inner membrane(GO:0031314) |
0.1 | 2.7 | GO:0031430 | M band(GO:0031430) |
0.1 | 0.7 | GO:0044613 | nuclear pore central transport channel(GO:0044613) |
0.1 | 1.6 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
0.1 | 13.7 | GO:0030141 | secretory granule(GO:0030141) |
0.1 | 2.8 | GO:0016235 | aggresome(GO:0016235) |
0.1 | 2.3 | GO:0030286 | dynein complex(GO:0030286) |
0.1 | 1.9 | GO:0001741 | XY body(GO:0001741) |
0.1 | 3.2 | GO:0002102 | podosome(GO:0002102) |
0.1 | 0.2 | GO:0031084 | BLOC-2 complex(GO:0031084) |
0.1 | 1.1 | GO:0043189 | NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562) |
0.1 | 0.9 | GO:0005688 | U6 snRNP(GO:0005688) |
0.1 | 0.5 | GO:0005638 | lamin filament(GO:0005638) |
0.1 | 0.2 | GO:0071001 | U4/U6 snRNP(GO:0071001) |
0.1 | 2.4 | GO:0060077 | inhibitory synapse(GO:0060077) |
0.1 | 3.1 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
0.1 | 1.3 | GO:0070822 | Sin3-type complex(GO:0070822) |
0.1 | 0.7 | GO:0005869 | dynactin complex(GO:0005869) |
0.1 | 0.9 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
0.1 | 0.3 | GO:0042719 | mitochondrial intermembrane space protein transporter complex(GO:0042719) |
0.1 | 0.5 | GO:0042382 | paraspeckles(GO:0042382) |
0.1 | 2.5 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
0.1 | 0.3 | GO:0032426 | stereocilium tip(GO:0032426) |
0.1 | 1.3 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
0.1 | 0.2 | GO:0005673 | transcription factor TFIIE complex(GO:0005673) |
0.1 | 3.6 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
0.1 | 2.0 | GO:0031201 | SNARE complex(GO:0031201) |
0.1 | 0.4 | GO:0097413 | Lewy body(GO:0097413) |
0.1 | 2.2 | GO:0005801 | cis-Golgi network(GO:0005801) |
0.1 | 19.1 | GO:0016607 | nuclear speck(GO:0016607) |
0.1 | 17.5 | GO:0005874 | microtubule(GO:0005874) |
0.1 | 5.9 | GO:0031514 | motile cilium(GO:0031514) |
0.1 | 1.3 | GO:0005930 | axoneme(GO:0005930) |
0.0 | 0.6 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
0.0 | 0.5 | GO:0000421 | autophagosome membrane(GO:0000421) |
0.0 | 0.4 | GO:0005787 | signal peptidase complex(GO:0005787) |
0.0 | 0.7 | GO:0030008 | TRAPP complex(GO:0030008) |
0.0 | 1.4 | GO:0031226 | intrinsic component of plasma membrane(GO:0031226) |
0.0 | 6.7 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
0.0 | 1.3 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
0.0 | 0.3 | GO:0005786 | signal recognition particle, endoplasmic reticulum targeting(GO:0005786) |
0.0 | 30.6 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
0.0 | 2.1 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
0.0 | 2.4 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
0.0 | 0.7 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
0.0 | 0.3 | GO:0032797 | SMN complex(GO:0032797) |
0.0 | 0.4 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
0.0 | 2.2 | GO:0000922 | spindle pole(GO:0000922) |
0.0 | 0.1 | GO:0031417 | NatC complex(GO:0031417) |
0.0 | 2.5 | GO:0043679 | axon terminus(GO:0043679) |
0.0 | 0.8 | GO:0045335 | phagocytic vesicle(GO:0045335) |
0.0 | 0.5 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
0.0 | 1.3 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
0.0 | 0.4 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
0.0 | 2.7 | GO:0031225 | anchored component of membrane(GO:0031225) |
0.0 | 0.2 | GO:0005851 | eukaryotic translation initiation factor 2B complex(GO:0005851) |
0.0 | 0.5 | GO:0035102 | PRC1 complex(GO:0035102) |
0.0 | 1.8 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
0.0 | 0.1 | GO:0032156 | septin cytoskeleton(GO:0032156) |
0.0 | 0.7 | GO:0005905 | clathrin-coated pit(GO:0005905) |
0.0 | 3.4 | GO:0032993 | protein-DNA complex(GO:0032993) |
0.0 | 0.7 | GO:0031304 | intrinsic component of mitochondrial inner membrane(GO:0031304) |
0.0 | 6.5 | GO:0009986 | cell surface(GO:0009986) |
0.0 | 0.1 | GO:0017109 | glutamate-cysteine ligase complex(GO:0017109) |
0.0 | 0.2 | GO:0000815 | ESCRT III complex(GO:0000815) |
0.0 | 0.2 | GO:0031464 | Cul4A-RING E3 ubiquitin ligase complex(GO:0031464) |
0.0 | 0.1 | GO:0061700 | Seh1-associated complex(GO:0035859) GATOR2 complex(GO:0061700) |
0.0 | 0.2 | GO:0010369 | chromocenter(GO:0010369) |
0.0 | 0.6 | GO:0005776 | autophagosome(GO:0005776) |
0.0 | 0.7 | GO:0005923 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
0.0 | 0.1 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453) |
0.0 | 0.1 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
0.0 | 1.0 | GO:0042641 | actomyosin(GO:0042641) |
0.0 | 1.6 | GO:0005769 | early endosome(GO:0005769) |
0.0 | 0.4 | GO:0015030 | Cajal body(GO:0015030) |
0.0 | 0.2 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
6.1 | 18.3 | GO:0022865 | transmembrane electron transfer carrier(GO:0022865) |
4.1 | 49.5 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
2.5 | 20.3 | GO:0032051 | clathrin light chain binding(GO:0032051) |
1.7 | 6.8 | GO:0061628 | H3K27me3 modified histone binding(GO:0061628) |
1.3 | 5.4 | GO:0030160 | GKAP/Homer scaffold activity(GO:0030160) |
1.1 | 2.1 | GO:0008568 | microtubule-severing ATPase activity(GO:0008568) |
1.0 | 6.1 | GO:0061649 | ubiquitinated histone binding(GO:0061649) |
0.9 | 3.8 | GO:0016909 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
0.9 | 7.2 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
0.9 | 3.5 | GO:0004844 | uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506) |
0.9 | 7.0 | GO:0005519 | cytoskeletal regulatory protein binding(GO:0005519) |
0.9 | 4.3 | GO:0032027 | myosin light chain binding(GO:0032027) |
0.8 | 4.2 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
0.8 | 2.3 | GO:0004069 | L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069) |
0.7 | 2.2 | GO:0071633 | dihydroceramidase activity(GO:0071633) |
0.6 | 2.5 | GO:0031800 | type 3 metabotropic glutamate receptor binding(GO:0031800) |
0.6 | 4.8 | GO:0031811 | G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812) |
0.5 | 14.8 | GO:0032183 | SUMO binding(GO:0032183) |
0.5 | 1.5 | GO:0034597 | phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597) |
0.5 | 5.3 | GO:0030235 | nitric-oxide synthase regulator activity(GO:0030235) |
0.5 | 1.4 | GO:0000822 | inositol hexakisphosphate binding(GO:0000822) |
0.4 | 2.8 | GO:0055131 | C3HC4-type RING finger domain binding(GO:0055131) |
0.4 | 15.2 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
0.3 | 2.5 | GO:0008889 | glycerophosphodiester phosphodiesterase activity(GO:0008889) |
0.3 | 0.9 | GO:0050816 | phosphothreonine binding(GO:0050816) |
0.3 | 6.4 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
0.3 | 12.2 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
0.3 | 9.3 | GO:0005112 | Notch binding(GO:0005112) |
0.3 | 1.0 | GO:0050833 | pyruvate transmembrane transporter activity(GO:0050833) |
0.3 | 1.5 | GO:0044547 | DNA topoisomerase binding(GO:0044547) |
0.2 | 3.5 | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) |
0.2 | 6.8 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
0.2 | 0.9 | GO:0017077 | oxidative phosphorylation uncoupler activity(GO:0017077) |
0.2 | 0.7 | GO:0003963 | RNA-3'-phosphate cyclase activity(GO:0003963) |
0.2 | 1.1 | GO:0047134 | protein-disulfide reductase activity(GO:0047134) |
0.2 | 1.4 | GO:0071558 | histone demethylase activity (H3-K27 specific)(GO:0071558) |
0.2 | 0.6 | GO:0070736 | protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) |
0.2 | 4.5 | GO:0042171 | lysophosphatidic acid acyltransferase activity(GO:0042171) |
0.2 | 2.3 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
0.2 | 4.8 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
0.2 | 1.3 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) |
0.2 | 2.8 | GO:0004862 | cAMP-dependent protein kinase inhibitor activity(GO:0004862) |
0.2 | 1.6 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
0.2 | 1.6 | GO:0042609 | CD4 receptor binding(GO:0042609) |
0.2 | 0.9 | GO:1904288 | BAT3 complex binding(GO:1904288) |
0.2 | 1.0 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
0.2 | 0.5 | GO:0071208 | histone pre-mRNA DCP binding(GO:0071208) U7 snRNA binding(GO:0071209) |
0.2 | 4.8 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
0.2 | 1.5 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
0.2 | 2.4 | GO:1904264 | ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264) |
0.1 | 2.3 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
0.1 | 6.0 | GO:0045182 | translation regulator activity(GO:0045182) |
0.1 | 2.5 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
0.1 | 37.2 | GO:0008017 | microtubule binding(GO:0008017) |
0.1 | 3.6 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
0.1 | 5.7 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
0.1 | 6.2 | GO:0046875 | ephrin receptor binding(GO:0046875) |
0.1 | 0.4 | GO:0005119 | smoothened binding(GO:0005119) |
0.1 | 2.4 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
0.1 | 1.3 | GO:0070008 | serine-type exopeptidase activity(GO:0070008) |
0.1 | 4.4 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
0.1 | 3.9 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
0.1 | 0.7 | GO:0019869 | chloride channel inhibitor activity(GO:0019869) |
0.1 | 1.1 | GO:0004017 | adenylate kinase activity(GO:0004017) |
0.1 | 0.6 | GO:0003854 | 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854) |
0.1 | 2.1 | GO:0016864 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
0.1 | 0.2 | GO:0047192 | 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192) |
0.1 | 0.8 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
0.1 | 0.3 | GO:0016309 | 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309) |
0.1 | 0.4 | GO:0004723 | calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) |
0.1 | 3.8 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
0.1 | 0.4 | GO:0004809 | tRNA (guanine-N2-)-methyltransferase activity(GO:0004809) |
0.1 | 0.8 | GO:0034450 | ubiquitin-ubiquitin ligase activity(GO:0034450) |
0.1 | 1.3 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
0.1 | 2.5 | GO:0051059 | NF-kappaB binding(GO:0051059) |
0.1 | 0.5 | GO:0016413 | O-acetyltransferase activity(GO:0016413) |
0.1 | 0.6 | GO:0030346 | protein phosphatase 2B binding(GO:0030346) |
0.1 | 0.7 | GO:0008474 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
0.1 | 1.2 | GO:0098632 | protein binding involved in cell-cell adhesion(GO:0098632) |
0.1 | 1.1 | GO:0004033 | aldo-keto reductase (NADP) activity(GO:0004033) |
0.1 | 2.0 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
0.1 | 1.8 | GO:0030552 | cAMP binding(GO:0030552) |
0.1 | 1.3 | GO:0008307 | structural constituent of muscle(GO:0008307) |
0.1 | 0.9 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
0.1 | 0.5 | GO:0008556 | sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556) |
0.1 | 0.7 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
0.1 | 0.8 | GO:0008484 | sulfuric ester hydrolase activity(GO:0008484) |
0.1 | 0.5 | GO:0003777 | microtubule motor activity(GO:0003777) |
0.1 | 0.9 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
0.1 | 1.5 | GO:0000175 | 3'-5'-exoribonuclease activity(GO:0000175) |
0.1 | 2.7 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
0.0 | 0.6 | GO:0004576 | oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
0.0 | 0.2 | GO:0030621 | U4 snRNA binding(GO:0030621) |
0.0 | 0.3 | GO:0005047 | signal recognition particle binding(GO:0005047) 7S RNA binding(GO:0008312) |
0.0 | 0.2 | GO:0030292 | protein tyrosine kinase inhibitor activity(GO:0030292) |
0.0 | 1.3 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
0.0 | 1.7 | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity(GO:0003755) |
0.0 | 0.4 | GO:0001055 | RNA polymerase II activity(GO:0001055) |
0.0 | 3.9 | GO:0008013 | beta-catenin binding(GO:0008013) |
0.0 | 0.6 | GO:0022889 | L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889) |
0.0 | 3.2 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
0.0 | 0.8 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
0.0 | 2.3 | GO:0048365 | Rac GTPase binding(GO:0048365) |
0.0 | 0.6 | GO:0031005 | filamin binding(GO:0031005) |
0.0 | 0.3 | GO:0015114 | phosphate ion transmembrane transporter activity(GO:0015114) |
0.0 | 0.2 | GO:0004392 | heme oxygenase (decyclizing) activity(GO:0004392) |
0.0 | 0.7 | GO:0042287 | MHC protein binding(GO:0042287) |
0.0 | 0.2 | GO:0016907 | G-protein coupled acetylcholine receptor activity(GO:0016907) |
0.0 | 0.6 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
0.0 | 1.5 | GO:0005484 | SNAP receptor activity(GO:0005484) |
0.0 | 0.3 | GO:0043023 | ribosomal large subunit binding(GO:0043023) |
0.0 | 0.2 | GO:0031748 | D1 dopamine receptor binding(GO:0031748) |
0.0 | 0.1 | GO:0004814 | arginine-tRNA ligase activity(GO:0004814) |
0.0 | 0.5 | GO:0043274 | phospholipase binding(GO:0043274) |
0.0 | 1.1 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
0.0 | 0.8 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
0.0 | 0.8 | GO:0003785 | actin monomer binding(GO:0003785) |
0.0 | 0.3 | GO:0034711 | inhibin binding(GO:0034711) |
0.0 | 0.7 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
0.0 | 0.3 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
0.0 | 0.1 | GO:0008475 | procollagen-lysine 5-dioxygenase activity(GO:0008475) |
0.0 | 1.5 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
0.0 | 0.5 | GO:0008483 | transaminase activity(GO:0008483) |
0.0 | 0.4 | GO:0070840 | dynein complex binding(GO:0070840) |
0.0 | 1.1 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
0.0 | 0.6 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
0.0 | 0.2 | GO:0003997 | acyl-CoA oxidase activity(GO:0003997) |
0.0 | 0.8 | GO:0050699 | WW domain binding(GO:0050699) |
0.0 | 4.7 | GO:0004930 | G-protein coupled receptor activity(GO:0004930) |
0.0 | 0.3 | GO:0051400 | BH domain binding(GO:0051400) |
0.0 | 0.2 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
0.0 | 4.5 | GO:0005096 | GTPase activator activity(GO:0005096) |
0.0 | 0.4 | GO:0070412 | R-SMAD binding(GO:0070412) |
0.0 | 0.0 | GO:0032795 | heterotrimeric G-protein binding(GO:0032795) |
0.0 | 0.1 | GO:0004357 | glutamate-cysteine ligase activity(GO:0004357) |
0.0 | 0.4 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
0.0 | 1.9 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
0.0 | 1.7 | GO:0030165 | PDZ domain binding(GO:0030165) |
0.0 | 0.1 | GO:0000832 | inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724) |
0.0 | 0.5 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
0.0 | 0.4 | GO:0050750 | low-density lipoprotein particle receptor binding(GO:0050750) |
0.0 | 1.6 | GO:0047485 | protein N-terminus binding(GO:0047485) |
0.0 | 0.1 | GO:0050897 | cobalt ion binding(GO:0050897) |
0.0 | 0.3 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
0.0 | 0.1 | GO:0015266 | protein channel activity(GO:0015266) |
0.0 | 0.8 | GO:0017137 | Rab GTPase binding(GO:0017137) |
0.0 | 0.1 | GO:0003917 | DNA topoisomerase type I activity(GO:0003917) |
0.0 | 0.2 | GO:0003746 | translation elongation factor activity(GO:0003746) |
0.0 | 0.3 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
0.0 | 0.3 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.1 | 47.8 | ST_WNT_CA2_CYCLIC_GMP_PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
0.3 | 9.1 | ST_MYOCYTE_AD_PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
0.2 | 4.0 | PID_RET_PATHWAY | Signaling events regulated by Ret tyrosine kinase |
0.1 | 1.8 | SA_G1_AND_S_PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
0.1 | 8.3 | PID_LKB1_PATHWAY | LKB1 signaling events |
0.1 | 1.3 | PID_S1P_S1P4_PATHWAY | S1P4 pathway |
0.1 | 6.7 | PID_RAC1_REG_PATHWAY | Regulation of RAC1 activity |
0.1 | 7.8 | PID_NOTCH_PATHWAY | Notch signaling pathway |
0.1 | 4.9 | PID_ECADHERIN_STABILIZATION_PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
0.1 | 3.9 | PID_FOXO_PATHWAY | FoxO family signaling |
0.1 | 2.2 | PID_NCADHERIN_PATHWAY | N-cadherin signaling events |
0.1 | 9.1 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
0.1 | 1.7 | PID_ARF6_PATHWAY | Arf6 signaling events |
0.1 | 0.7 | PID_FAK_PATHWAY | Signaling events mediated by focal adhesion kinase |
0.1 | 1.5 | PID_IL8_CXCR1_PATHWAY | IL8- and CXCR1-mediated signaling events |
0.1 | 2.2 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
0.1 | 0.5 | PID_IL5_PATHWAY | IL5-mediated signaling events |
0.1 | 10.7 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
0.0 | 2.5 | PID_CERAMIDE_PATHWAY | Ceramide signaling pathway |
0.0 | 1.5 | PID_RAS_PATHWAY | Regulation of Ras family activation |
0.0 | 3.7 | PID_P73PATHWAY | p73 transcription factor network |
0.0 | 1.5 | PID_HEDGEHOG_GLI_PATHWAY | Hedgehog signaling events mediated by Gli proteins |
0.0 | 0.7 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
0.0 | 0.8 | PID_INTEGRIN_A4B1_PATHWAY | Alpha4 beta1 integrin signaling events |
0.0 | 1.5 | PID_AR_TF_PATHWAY | Regulation of Androgen receptor activity |
0.0 | 0.3 | PID_IL3_PATHWAY | IL3-mediated signaling events |
0.0 | 0.4 | PID_P38_GAMMA_DELTA_PATHWAY | Signaling mediated by p38-gamma and p38-delta |
0.0 | 0.7 | PID_ARF_3PATHWAY | Arf1 pathway |
0.0 | 0.9 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
0.0 | 0.9 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
0.0 | 3.2 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
0.0 | 0.6 | PID_RB_1PATHWAY | Regulation of retinoblastoma protein |
0.0 | 0.8 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.0 | 50.4 | REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
0.5 | 13.0 | REACTOME_OTHER_SEMAPHORIN_INTERACTIONS | Genes involved in Other semaphorin interactions |
0.3 | 1.3 | REACTOME_G_PROTEIN_ACTIVATION | Genes involved in G-protein activation |
0.3 | 2.4 | REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION | Genes involved in FGFR4 ligand binding and activation |
0.3 | 3.7 | REACTOME_HDL_MEDIATED_LIPID_TRANSPORT | Genes involved in HDL-mediated lipid transport |
0.3 | 1.9 | REACTOME_IRAK1_RECRUITS_IKK_COMPLEX | Genes involved in IRAK1 recruits IKK complex |
0.3 | 6.5 | REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS | Genes involved in Activation of BH3-only proteins |
0.2 | 8.8 | REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS | Genes involved in Trafficking of AMPA receptors |
0.2 | 3.0 | REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
0.2 | 4.4 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
0.2 | 3.8 | REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 | Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
0.2 | 6.7 | REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
0.2 | 2.2 | REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
0.1 | 4.7 | REACTOME_SYNTHESIS_OF_PA | Genes involved in Synthesis of PA |
0.1 | 1.7 | REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
0.1 | 9.5 | REACTOME_REGULATION_OF_INSULIN_SECRETION | Genes involved in Regulation of Insulin Secretion |
0.1 | 5.0 | REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
0.1 | 1.3 | REACTOME_REGULATION_OF_IFNG_SIGNALING | Genes involved in Regulation of IFNG signaling |
0.1 | 2.6 | REACTOME_KINESINS | Genes involved in Kinesins |
0.1 | 3.3 | REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
0.1 | 6.4 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
0.1 | 1.4 | REACTOME_ACTIVATION_OF_RAC | Genes involved in Activation of Rac |
0.1 | 1.3 | REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS | Genes involved in Regulation of Water Balance by Renal Aquaporins |
0.1 | 0.8 | REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
0.1 | 0.9 | REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
0.1 | 1.1 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
0.1 | 2.9 | REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT | Genes involved in Mitochondrial Protein Import |
0.1 | 1.7 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
0.1 | 1.3 | REACTOME_STRIATED_MUSCLE_CONTRACTION | Genes involved in Striated Muscle Contraction |
0.1 | 0.9 | REACTOME_RAP1_SIGNALLING | Genes involved in Rap1 signalling |
0.0 | 0.5 | REACTOME_COPI_MEDIATED_TRANSPORT | Genes involved in COPI Mediated Transport |
0.0 | 0.8 | REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP | Genes involved in Destabilization of mRNA by Tristetraprolin (TTP) |
0.0 | 0.6 | REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
0.0 | 1.2 | REACTOME_SIGNALING_BY_ROBO_RECEPTOR | Genes involved in Signaling by Robo receptor |
0.0 | 1.1 | REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
0.0 | 0.5 | REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
0.0 | 1.2 | REACTOME_EGFR_DOWNREGULATION | Genes involved in EGFR downregulation |
0.0 | 1.5 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
0.0 | 0.6 | REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
0.0 | 0.8 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
0.0 | 2.2 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
0.0 | 0.6 | REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING | Genes involved in DCC mediated attractive signaling |
0.0 | 0.5 | REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
0.0 | 1.1 | REACTOME_MRNA_SPLICING_MINOR_PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
0.0 | 1.1 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
0.0 | 0.6 | REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
0.0 | 0.9 | REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
0.0 | 0.9 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
0.0 | 1.9 | REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
0.0 | 2.3 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
0.0 | 1.1 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
0.0 | 0.7 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
0.0 | 1.6 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
0.0 | 0.2 | REACTOME_FORMATION_OF_TRANSCRIPTION_COUPLED_NER_TC_NER_REPAIR_COMPLEX | Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex |
0.0 | 0.4 | REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
0.0 | 0.5 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |