Motif ID: Nkx6-2
Z-value: 0.498

Transcription factors associated with Nkx6-2:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Nkx6-2 | ENSMUSG00000041309.11 | Nkx6-2 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Nkx6-2 | mm10_v2_chr7_-_139582790_139582808 | -0.13 | 4.1e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 5.0 | GO:0060164 | regulation of timing of neuron differentiation(GO:0060164) |
0.6 | 1.8 | GO:0016554 | cytidine to uridine editing(GO:0016554) |
0.2 | 0.5 | GO:0060478 | acrosomal vesicle exocytosis(GO:0060478) |
0.2 | 0.8 | GO:0060690 | epithelial cell differentiation involved in salivary gland development(GO:0060690) |
0.1 | 0.4 | GO:0042536 | negative regulation of tumor necrosis factor biosynthetic process(GO:0042536) |
0.1 | 0.3 | GO:0044313 | protein K6-linked deubiquitination(GO:0044313) |
0.1 | 0.4 | GO:0010735 | positive regulation of transcription via serum response element binding(GO:0010735) |
0.1 | 0.7 | GO:0021785 | branchiomotor neuron axon guidance(GO:0021785) |
0.1 | 0.2 | GO:0044837 | assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837) |
0.1 | 0.2 | GO:0006428 | isoleucyl-tRNA aminoacylation(GO:0006428) |
0.1 | 0.3 | GO:0021631 | optic nerve morphogenesis(GO:0021631) |
0.1 | 1.2 | GO:0071803 | keratinocyte development(GO:0003334) positive regulation of podosome assembly(GO:0071803) |
0.1 | 0.3 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
0.1 | 0.4 | GO:0043654 | skeletal muscle satellite cell activation(GO:0014719) recognition of apoptotic cell(GO:0043654) |
0.1 | 0.4 | GO:0018243 | protein O-linked glycosylation via threonine(GO:0018243) |
0.1 | 0.3 | GO:0051987 | positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987) |
0.1 | 0.4 | GO:0006344 | maintenance of chromatin silencing(GO:0006344) |
0.0 | 0.2 | GO:0075525 | viral translational termination-reinitiation(GO:0075525) |
0.0 | 0.2 | GO:0007412 | axon target recognition(GO:0007412) |
0.0 | 0.2 | GO:0098909 | establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200) regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909) |
0.0 | 1.2 | GO:0007026 | negative regulation of microtubule depolymerization(GO:0007026) |
0.0 | 0.2 | GO:0060266 | negative regulation of respiratory burst involved in inflammatory response(GO:0060266) |
0.0 | 0.3 | GO:0097475 | motor neuron migration(GO:0097475) |
0.0 | 0.6 | GO:0008090 | retrograde axonal transport(GO:0008090) |
0.0 | 0.2 | GO:0010804 | negative regulation of tumor necrosis factor-mediated signaling pathway(GO:0010804) |
0.0 | 0.3 | GO:0043653 | mitochondrial fragmentation involved in apoptotic process(GO:0043653) |
0.0 | 1.4 | GO:0002066 | columnar/cuboidal epithelial cell development(GO:0002066) |
0.0 | 0.4 | GO:0051764 | actin crosslink formation(GO:0051764) |
0.0 | 2.5 | GO:0051028 | mRNA transport(GO:0051028) |
0.0 | 0.6 | GO:0097352 | autophagosome maturation(GO:0097352) |
0.0 | 0.3 | GO:0006851 | mitochondrial calcium ion transport(GO:0006851) |
0.0 | 0.1 | GO:0032596 | protein transport into membrane raft(GO:0032596) |
0.0 | 0.1 | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) |
0.0 | 0.1 | GO:0038018 | Wnt receptor catabolic process(GO:0038018) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 0.6 | GO:0031673 | H zone(GO:0031673) |
0.1 | 0.4 | GO:0042585 | germinal vesicle(GO:0042585) |
0.1 | 1.2 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
0.1 | 0.8 | GO:0005915 | zonula adherens(GO:0005915) |
0.0 | 0.3 | GO:0033391 | chromatoid body(GO:0033391) |
0.0 | 0.3 | GO:0030015 | CCR4-NOT core complex(GO:0030015) |
0.0 | 1.2 | GO:0002102 | podosome(GO:0002102) |
0.0 | 5.7 | GO:0044798 | nuclear transcription factor complex(GO:0044798) |
0.0 | 0.3 | GO:1990023 | mitotic spindle midzone(GO:1990023) |
0.0 | 0.2 | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541) |
0.0 | 0.5 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
0.0 | 0.2 | GO:0090543 | Flemming body(GO:0090543) |
0.0 | 0.3 | GO:0046930 | pore complex(GO:0046930) |
0.0 | 0.3 | GO:0030008 | TRAPP complex(GO:0030008) |
0.0 | 0.4 | GO:0071564 | npBAF complex(GO:0071564) |
0.0 | 0.4 | GO:0001891 | phagocytic cup(GO:0001891) |
0.0 | 0.4 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
0.0 | 0.1 | GO:0005642 | annulate lamellae(GO:0005642) |
0.0 | 0.1 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
0.0 | 0.2 | GO:0005652 | nuclear lamina(GO:0005652) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 1.8 | GO:0004126 | cytidine deaminase activity(GO:0004126) |
0.2 | 0.7 | GO:0033883 | pyridoxal phosphatase activity(GO:0033883) |
0.2 | 1.2 | GO:0005519 | cytoskeletal regulatory protein binding(GO:0005519) |
0.1 | 0.5 | GO:0004792 | thiosulfate sulfurtransferase activity(GO:0004792) |
0.1 | 1.0 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
0.1 | 2.1 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
0.1 | 0.2 | GO:0031871 | proteinase activated receptor binding(GO:0031871) |
0.1 | 0.2 | GO:0004822 | isoleucine-tRNA ligase activity(GO:0004822) |
0.1 | 0.3 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
0.1 | 0.4 | GO:0001849 | complement component C1q binding(GO:0001849) |
0.0 | 0.7 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
0.0 | 0.2 | GO:0031694 | alpha-2A adrenergic receptor binding(GO:0031694) |
0.0 | 0.3 | GO:0015288 | porin activity(GO:0015288) |
0.0 | 0.4 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
0.0 | 0.3 | GO:0008526 | phosphatidylinositol transporter activity(GO:0008526) |
0.0 | 0.1 | GO:0017057 | 6-phosphogluconolactonase activity(GO:0017057) |
0.0 | 0.4 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
0.0 | 0.3 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
0.0 | 0.7 | GO:0018024 | histone-lysine N-methyltransferase activity(GO:0018024) |
0.0 | 0.2 | GO:0001530 | lipopolysaccharide binding(GO:0001530) |
0.0 | 0.5 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
0.0 | 0.1 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
0.0 | 0.1 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
0.0 | 0.2 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) mitogen-activated protein kinase p38 binding(GO:0048273) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 0.8 | PID_ECADHERIN_KERATINOCYTE_PATHWAY | E-cadherin signaling in keratinocytes |
0.0 | 1.2 | PID_LKB1_PATHWAY | LKB1 signaling events |
0.0 | 0.3 | PID_SYNDECAN_2_PATHWAY | Syndecan-2-mediated signaling events |
0.0 | 0.5 | PID_NFAT_TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 0.4 | REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
0.0 | 0.7 | REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
0.0 | 1.0 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
0.0 | 0.6 | REACTOME_PACKAGING_OF_TELOMERE_ENDS | Genes involved in Packaging Of Telomere Ends |
0.0 | 2.2 | REACTOME_DIABETES_PATHWAYS | Genes involved in Diabetes pathways |
0.0 | 0.3 | REACTOME_KINESINS | Genes involved in Kinesins |
0.0 | 0.2 | REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |