Motif ID: Runx1

Z-value: 0.856


Transcription factors associated with Runx1:

Gene SymbolEntrez IDGene Name
Runx1 ENSMUSG00000022952.10 Runx1



Activity profile for motif Runx1.

activity profile for motif Runx1


Sorted Z-values histogram for motif Runx1

Sorted Z-values for motif Runx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Runx1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_66801577 9.628 ENSMUST00000168589.1
Sla
src-like adaptor
chr16_+_42907563 8.687 ENSMUST00000151244.1
ENSMUST00000114694.2
Zbtb20

zinc finger and BTB domain containing 20

chr17_+_3397189 6.239 ENSMUST00000072156.6
Tiam2
T cell lymphoma invasion and metastasis 2
chr3_-_107760221 5.392 ENSMUST00000153114.1
ENSMUST00000118593.1
ENSMUST00000120243.1
Csf1


colony stimulating factor 1 (macrophage)


chr8_-_11008458 5.366 ENSMUST00000040514.6
Irs2
insulin receptor substrate 2
chr13_+_76579670 3.698 ENSMUST00000126960.1
ENSMUST00000109583.2
Mctp1

multiple C2 domains, transmembrane 1

chr16_+_43510267 3.449 ENSMUST00000114695.2
Zbtb20
zinc finger and BTB domain containing 20
chrX_+_151344171 3.336 ENSMUST00000073364.5
Fam120c
family with sequence similarity 120, member C
chr13_+_49608030 3.324 ENSMUST00000021822.5
Ogn
osteoglycin
chr12_-_25096080 3.114 ENSMUST00000020974.6
Id2
inhibitor of DNA binding 2
chr15_-_76090013 3.102 ENSMUST00000019516.4
Nrbp2
nuclear receptor binding protein 2
chr12_-_34528844 2.779 ENSMUST00000110819.2
Hdac9
histone deacetylase 9
chrX_+_159697308 2.725 ENSMUST00000123433.1
Sh3kbp1
SH3-domain kinase binding protein 1
chr17_+_75178797 2.499 ENSMUST00000112516.1
ENSMUST00000135447.1
Ltbp1

latent transforming growth factor beta binding protein 1

chr15_-_102722120 2.341 ENSMUST00000171838.1
Calcoco1
calcium binding and coiled coil domain 1
chr2_+_37516618 2.310 ENSMUST00000065441.6
Gpr21
G protein-coupled receptor 21
chr2_-_52335134 2.134 ENSMUST00000075301.3
Neb
nebulin
chr4_-_14621805 2.129 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chr1_-_14310198 2.128 ENSMUST00000168081.2
ENSMUST00000027066.6
Eya1

eyes absent 1 homolog (Drosophila)

chr15_-_102722150 2.121 ENSMUST00000023818.3
Calcoco1
calcium binding and coiled coil domain 1
chr2_-_52558539 2.094 ENSMUST00000102760.3
ENSMUST00000102761.2
Cacnb4

calcium channel, voltage-dependent, beta 4 subunit

chr17_+_75178911 2.090 ENSMUST00000112514.1
Ltbp1
latent transforming growth factor beta binding protein 1
chr15_-_37459327 2.036 ENSMUST00000119730.1
ENSMUST00000120746.1
Ncald

neurocalcin delta

chr1_-_169747634 1.982 ENSMUST00000027991.5
ENSMUST00000111357.1
Rgs4

regulator of G-protein signaling 4

chr4_-_6990774 1.832 ENSMUST00000039987.3
Tox
thymocyte selection-associated high mobility group box
chr2_-_116065798 1.778 ENSMUST00000110907.1
ENSMUST00000110908.2
Meis2

Meis homeobox 2

chr6_+_17491216 1.640 ENSMUST00000080469.5
Met
met proto-oncogene
chr8_+_76902277 1.609 ENSMUST00000109912.1
ENSMUST00000128862.1
ENSMUST00000109911.1
Nr3c2


nuclear receptor subfamily 3, group C, member 2


chr11_+_116030304 1.604 ENSMUST00000021116.5
ENSMUST00000106452.1
Unk

unkempt homolog (Drosophila)

chr11_+_75531690 1.584 ENSMUST00000149727.1
ENSMUST00000042561.7
ENSMUST00000108433.1
ENSMUST00000143035.1
Slc43a2



solute carrier family 43, member 2



chr11_+_75532127 1.531 ENSMUST00000127226.1
Slc43a2
solute carrier family 43, member 2
chr9_+_113812547 1.470 ENSMUST00000166734.2
ENSMUST00000111838.2
ENSMUST00000163895.2
Clasp2


CLIP associating protein 2


chr2_-_20943413 1.463 ENSMUST00000140230.1
Arhgap21
Rho GTPase activating protein 21
chr7_-_25132473 1.421 ENSMUST00000108418.4
ENSMUST00000108415.3
ENSMUST00000098679.3
ENSMUST00000175774.2
ENSMUST00000108417.3
ENSMUST00000108416.3
ENSMUST00000108414.1
ENSMUST00000108413.1
ENSMUST00000176408.1
Pou2f2








POU domain, class 2, transcription factor 2








chr2_+_164948219 1.341 ENSMUST00000017881.2
Mmp9
matrix metallopeptidase 9
chr4_+_102760294 1.257 ENSMUST00000072481.5
ENSMUST00000156596.1
ENSMUST00000080728.6
ENSMUST00000106882.2
Sgip1



SH3-domain GRB2-like (endophilin) interacting protein 1



chr14_+_31641051 1.235 ENSMUST00000090147.6
Btd
biotinidase
chr6_+_17749170 1.204 ENSMUST00000053148.7
ENSMUST00000115417.3
St7

suppression of tumorigenicity 7

chr2_+_32629467 1.203 ENSMUST00000068271.4
Ak1
adenylate kinase 1
chr16_-_85901118 1.174 ENSMUST00000023611.5
Adamts5
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)
chr17_-_90455872 1.142 ENSMUST00000174337.1
ENSMUST00000172466.1
Nrxn1

neurexin I

chr3_-_88296838 1.120 ENSMUST00000010682.3
Tsacc
TSSK6 activating co-chaperone
chr4_-_70410422 1.117 ENSMUST00000144099.1
Cdk5rap2
CDK5 regulatory subunit associated protein 2
chr15_+_62037986 1.013 ENSMUST00000182956.1
ENSMUST00000182075.1
ENSMUST00000180432.2
ENSMUST00000181416.2
ENSMUST00000181657.2
Pvt1




plasmacytoma variant translocation 1




chr1_+_152399824 1.011 ENSMUST00000044311.8
Colgalt2
collagen beta(1-O)galactosyltransferase 2
chr8_+_105690906 1.008 ENSMUST00000062574.6
Rltpr
RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
chr4_+_133176336 0.971 ENSMUST00000105912.1
Wasf2
WAS protein family, member 2
chr5_+_104435112 0.962 ENSMUST00000031243.8
ENSMUST00000086833.6
ENSMUST00000112748.1
ENSMUST00000112746.1
ENSMUST00000145084.1
ENSMUST00000132457.1
Spp1





secreted phosphoprotein 1





chrX_-_57338598 0.954 ENSMUST00000033468.4
ENSMUST00000114736.1
Arhgef6

Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6

chr10_+_69925954 0.918 ENSMUST00000181974.1
ENSMUST00000182795.1
ENSMUST00000182437.1
Ank3


ankyrin 3, epithelial


chr15_+_80711292 0.911 ENSMUST00000067689.7
Tnrc6b
trinucleotide repeat containing 6b
chr11_+_75532099 0.874 ENSMUST00000169547.2
Slc43a2
solute carrier family 43, member 2
chr10_+_19934472 0.869 ENSMUST00000095806.3
ENSMUST00000120259.1
Map3k5

mitogen-activated protein kinase kinase kinase 5

chr1_-_140183404 0.822 ENSMUST00000066859.6
ENSMUST00000111976.2
Cfh

complement component factor h

chr18_+_37411674 0.821 ENSMUST00000051126.2
Pcdhb10
protocadherin beta 10
chr15_+_9436028 0.812 ENSMUST00000042360.3
Capsl
calcyphosine-like
chr3_-_88296979 0.803 ENSMUST00000107556.3
Tsacc
TSSK6 activating co-chaperone
chrX_-_20950597 0.802 ENSMUST00000009550.7
Elk1
ELK1, member of ETS oncogene family
chr6_+_136954521 0.790 ENSMUST00000137768.1
Pde6h
phosphodiesterase 6H, cGMP-specific, cone, gamma
chr2_+_32721055 0.789 ENSMUST00000074248.4
Sh2d3c
SH2 domain containing 3C
chr1_+_36307745 0.784 ENSMUST00000142319.1
ENSMUST00000097778.2
ENSMUST00000115031.1
ENSMUST00000115032.1
ENSMUST00000137906.1
ENSMUST00000115029.1
Arid5a





AT rich interactive domain 5A (MRF1-like)





chr1_+_34160253 0.751 ENSMUST00000183302.1
Dst
dystonin
chr11_-_52282564 0.740 ENSMUST00000086844.3
Tcf7
transcription factor 7, T cell specific
chr14_-_124677089 0.722 ENSMUST00000095529.3
Fgf14
fibroblast growth factor 14
chr16_+_91391721 0.716 ENSMUST00000160764.1
Gm21970
predicted gene 21970
chr2_+_79707780 0.696 ENSMUST00000090760.2
ENSMUST00000040863.4
ENSMUST00000111780.2
Ppp1r1c


protein phosphatase 1, regulatory (inhibitor) subunit 1C


chr17_+_35236556 0.658 ENSMUST00000068261.8
Atp6v1g2
ATPase, H+ transporting, lysosomal V1 subunit G2
chr6_+_136518820 0.655 ENSMUST00000032335.6
Atf7ip
activating transcription factor 7 interacting protein
chr17_+_33638056 0.646 ENSMUST00000052079.7
Pram1
PML-RAR alpha-regulated adaptor molecule 1
chr1_-_168431896 0.638 ENSMUST00000176540.1
Pbx1
pre B cell leukemia homeobox 1
chr12_+_95692212 0.627 ENSMUST00000057324.3
Flrt2
fibronectin leucine rich transmembrane protein 2
chr10_-_14718191 0.626 ENSMUST00000020016.4
Gje1
gap junction protein, epsilon 1
chr4_-_14621494 0.615 ENSMUST00000149633.1
Slc26a7
solute carrier family 26, member 7
chr1_-_140183283 0.609 ENSMUST00000111977.1
Cfh
complement component factor h
chr15_-_98607611 0.595 ENSMUST00000096224.4
Adcy6
adenylate cyclase 6
chr3_+_95282897 0.594 ENSMUST00000039537.7
ENSMUST00000107187.2
Fam63a

family with sequence similarity 63, member A

chrX_-_8090442 0.529 ENSMUST00000033505.6
Was
Wiskott-Aldrich syndrome homolog (human)
chr2_+_172393794 0.517 ENSMUST00000099061.2
ENSMUST00000103073.2
Cass4

Cas scaffolding protein family member 4

chr5_-_98030727 0.480 ENSMUST00000031281.9
Antxr2
anthrax toxin receptor 2
chr7_-_90129339 0.474 ENSMUST00000181189.1
2310010J17Rik
RIKEN cDNA 2310010J17 gene
chr19_-_10880370 0.465 ENSMUST00000133303.1
Tmem109
transmembrane protein 109
chr2_+_18672384 0.457 ENSMUST00000171845.1
ENSMUST00000061158.4
Commd3

COMM domain containing 3

chr2_-_32741016 0.438 ENSMUST00000009695.2
6330409D20Rik
RIKEN cDNA 6330409D20 gene
chr7_+_30565410 0.411 ENSMUST00000043850.7
Igflr1
IGF-like family receptor 1
chr15_-_97844254 0.408 ENSMUST00000119670.1
ENSMUST00000116409.2
Hdac7

histone deacetylase 7

chr1_+_160044374 0.387 ENSMUST00000163892.1
4930523C07Rik
RIKEN cDNA 4930523C07 gene
chr7_+_44572370 0.383 ENSMUST00000002274.8
Napsa
napsin A aspartic peptidase
chr4_-_46404224 0.369 ENSMUST00000107764.2
Hemgn
hemogen
chr7_-_43533171 0.343 ENSMUST00000004728.5
ENSMUST00000039861.5
Cd33

CD33 antigen

chr14_-_31640878 0.343 ENSMUST00000167066.1
ENSMUST00000127204.2
ENSMUST00000022437.8
Hacl1


2-hydroxyacyl-CoA lyase 1


chrX_+_107255878 0.338 ENSMUST00000101294.2
ENSMUST00000118820.1
ENSMUST00000120971.1
Gpr174


G protein-coupled receptor 174


chr11_-_110168073 0.337 ENSMUST00000044850.3
Abca9
ATP-binding cassette, sub-family A (ABC1), member 9
chr5_-_75044562 0.333 ENSMUST00000075452.5
Chic2
cysteine-rich hydrophobic domain 2
chr15_-_97844164 0.333 ENSMUST00000120683.1
Hdac7
histone deacetylase 7
chr11_-_116198701 0.311 ENSMUST00000072948.4
Acox1
acyl-Coenzyme A oxidase 1, palmitoyl
chr14_-_66280949 0.292 ENSMUST00000111121.1
ENSMUST00000022622.7
ENSMUST00000089250.2
Ptk2b


PTK2 protein tyrosine kinase 2 beta


chr5_-_92328068 0.246 ENSMUST00000113093.3
Cxcl9
chemokine (C-X-C motif) ligand 9
chrX_+_48623737 0.237 ENSMUST00000114936.1
Slc25a14
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr16_+_32271468 0.236 ENSMUST00000093183.3
Smco1
single-pass membrane protein with coiled-coil domains 1
chr7_-_133709051 0.225 ENSMUST00000124759.1
ENSMUST00000106144.1
Uros

uroporphyrinogen III synthase

chr9_-_107770945 0.220 ENSMUST00000183248.1
ENSMUST00000182022.1
ENSMUST00000035199.6
ENSMUST00000182659.1
Rbm5



RNA binding motif protein 5



chr1_+_160044564 0.212 ENSMUST00000168359.1
4930523C07Rik
RIKEN cDNA 4930523C07 gene
chr11_-_77078404 0.200 ENSMUST00000102494.1
Ccdc55
coiled-coil domain containing 55
chr3_+_96181151 0.185 ENSMUST00000035371.8
Sv2a
synaptic vesicle glycoprotein 2 a
chr1_-_168432270 0.172 ENSMUST00000072863.4
Pbx1
pre B cell leukemia homeobox 1
chr8_+_94386438 0.170 ENSMUST00000161576.1
Herpud1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr4_-_14621669 0.166 ENSMUST00000143105.1
Slc26a7
solute carrier family 26, member 7
chr7_+_24370255 0.159 ENSMUST00000171904.1
Kcnn4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr7_-_133708958 0.143 ENSMUST00000106146.1
Uros
uroporphyrinogen III synthase
chr7_-_133709069 0.116 ENSMUST00000106145.3
Uros
uroporphyrinogen III synthase
chr2_+_164460945 0.115 ENSMUST00000072452.4
Sys1
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)
chr19_+_8839298 0.087 ENSMUST00000160556.1
Bscl2
Bernardinelli-Seip congenital lipodystrophy 2 homolog (human)
chr2_+_21367532 0.084 ENSMUST00000055946.7
Gpr158
G protein-coupled receptor 158
chr17_+_4994904 0.071 ENSMUST00000092723.4
ENSMUST00000115797.2
Arid1b

AT rich interactive domain 1B (SWI-like)

chr3_-_89093358 0.054 ENSMUST00000090929.5
ENSMUST00000052539.6
Rusc1

RUN and SH3 domain containing 1

chr2_-_26021532 0.046 ENSMUST00000136750.1
Ubac1
ubiquitin associated domain containing 1
chr10_-_127288999 0.044 ENSMUST00000119078.1
Mbd6
methyl-CpG binding domain protein 6
chr11_-_79530569 0.043 ENSMUST00000103236.3
ENSMUST00000170799.1
ENSMUST00000170422.2
Evi2a

Evi2b
ecotropic viral integration site 2a

ecotropic viral integration site 2b
chr10_-_127288851 0.038 ENSMUST00000156208.1
ENSMUST00000026476.6
Mbd6

methyl-CpG binding domain protein 6

chr8_+_94386486 0.038 ENSMUST00000034220.7
Herpud1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr19_+_5568002 0.035 ENSMUST00000096318.3
Ap5b1
adaptor-related protein complex 5, beta 1 subunit
chr11_-_102218923 0.031 ENSMUST00000131254.1
Hdac5
histone deacetylase 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.4 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.6 3.1 GO:0045578 negative regulation of B cell differentiation(GO:0045578) epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.5 5.4 GO:0002903 negative regulation of B cell apoptotic process(GO:0002903)
0.4 2.9 GO:0019532 oxalate transport(GO:0019532)
0.4 2.1 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.3 3.5 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.3 12.1 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.3 1.5 GO:0051684 maintenance of Golgi location(GO:0051684)
0.3 1.1 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.3 1.3 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.2 1.0 GO:0035937 androgen catabolic process(GO:0006710) estrogen secretion(GO:0035937) estradiol secretion(GO:0035938) regulation of estrogen secretion(GO:2000861) regulation of estradiol secretion(GO:2000864)
0.2 1.4 GO:0045919 complement activation, alternative pathway(GO:0006957) positive regulation of cytolysis(GO:0045919)
0.2 1.6 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.2 2.1 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.2 1.5 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091) negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.2 1.2 GO:0046103 ADP biosynthetic process(GO:0006172) inosine biosynthetic process(GO:0046103)
0.2 0.8 GO:2000318 positive regulation of T-helper 17 type immune response(GO:2000318)
0.2 1.1 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.2 4.6 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.1 0.6 GO:0035811 negative regulation of urine volume(GO:0035811)
0.1 1.6 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.1 0.7 GO:1901843 positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.1 1.3 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.1 0.5 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.1 0.5 GO:0006780 uroporphyrinogen III biosynthetic process(GO:0006780)
0.1 8.1 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.1 0.6 GO:0043313 regulation of neutrophil degranulation(GO:0043313)
0.1 1.6 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.1 0.7 GO:0002681 somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153)
0.1 0.9 GO:0072658 positive regulation of cell communication by electrical coupling(GO:0010650) maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 0.6 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.1 0.3 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.1 0.4 GO:0043129 surfactant homeostasis(GO:0043129)
0.1 0.9 GO:0060213 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
0.1 0.3 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.1 1.4 GO:0048305 immunoglobulin secretion(GO:0048305)
0.1 0.9 GO:1902170 cellular response to reactive nitrogen species(GO:1902170)
0.1 1.2 GO:0006767 water-soluble vitamin metabolic process(GO:0006767)
0.1 2.3 GO:0040018 positive regulation of multicellular organism growth(GO:0040018)
0.1 3.3 GO:0015807 L-amino acid transport(GO:0015807)
0.0 1.0 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592)
0.0 0.7 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.8 GO:0008090 retrograde axonal transport(GO:0008090)
0.0 0.8 GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742) positive regulation of ERBB signaling pathway(GO:1901186)
0.0 0.8 GO:0030325 adrenal gland development(GO:0030325)
0.0 4.5 GO:0030518 intracellular steroid hormone receptor signaling pathway(GO:0030518)
0.0 0.2 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.0 5.5 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 1.3 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.0 1.4 GO:0045214 sarcomere organization(GO:0045214)
0.0 1.2 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0 2.0 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.0 1.4 GO:0008542 visual learning(GO:0008542)
0.0 2.8 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 0.1 GO:0097026 dendritic cell dendrite assembly(GO:0097026)
0.0 0.2 GO:0046541 saliva secretion(GO:0046541)
0.0 0.2 GO:0010818 T cell chemotaxis(GO:0010818)
0.0 0.7 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.0 0.2 GO:0014052 regulation of gamma-aminobutyric acid secretion(GO:0014052)
0.0 2.2 GO:0008360 regulation of cell shape(GO:0008360)
0.0 0.1 GO:0000042 protein targeting to Golgi(GO:0000042)
0.0 0.5 GO:1901998 toxin transport(GO:1901998)
0.0 0.8 GO:0007254 JNK cascade(GO:0007254)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.4 GO:1990682 CSF1-CSF1R complex(GO:1990682)
1.5 4.6 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.4 1.5 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.2 0.8 GO:0031673 H zone(GO:0031673)
0.2 0.9 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.2 1.2 GO:0001520 outer dense fiber(GO:0001520)
0.1 1.1 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 1.3 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 2.1 GO:0005865 striated muscle thin filament(GO:0005865)
0.1 1.0 GO:0031209 SCAR complex(GO:0031209)
0.1 1.1 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 2.1 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.4 GO:0097208 alveolar lamellar body(GO:0097208)
0.0 7.0 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 0.9 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.6 GO:0005922 connexon complex(GO:0005922)
0.0 0.2 GO:1990037 Lewy body core(GO:1990037)
0.0 0.7 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0 0.6 GO:0031528 microvillus membrane(GO:0031528)
0.0 3.6 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 1.6 GO:0009925 basal plasma membrane(GO:0009925)
0.0 2.1 GO:0032993 protein-DNA complex(GO:0032993)
0.0 0.1 GO:0016514 SWI/SNF complex(GO:0016514)
0.0 1.0 GO:0045177 apical part of cell(GO:0045177)
0.0 0.6 GO:0043234 protein complex(GO:0043234)
0.0 5.2 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.7 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 2.1 GO:0030139 endocytic vesicle(GO:0030139)
0.0 1.3 GO:0072562 blood microparticle(GO:0072562)
0.0 7.5 GO:0000785 chromatin(GO:0000785)
0.0 2.4 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.1 GO:0010369 chromocenter(GO:0010369)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.6 GO:0050436 microfibril binding(GO:0050436)
0.6 2.3 GO:0004952 dopamine neurotransmitter receptor activity(GO:0004952)
0.4 1.6 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.4 1.4 GO:0001851 complement component C3b binding(GO:0001851)
0.3 2.9 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.2 9.5 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.2 4.5 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.2 1.6 GO:1990715 mRNA CDS binding(GO:1990715)
0.2 3.6 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1 2.1 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 4.7 GO:0071889 14-3-3 protein binding(GO:0071889)
0.1 0.7 GO:0004920 interleukin-10 receptor activity(GO:0004920)
0.1 1.2 GO:0004017 adenylate kinase activity(GO:0004017)
0.1 1.5 GO:0002162 dystroglycan binding(GO:0002162)
0.1 0.6 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.1 1.1 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 4.0 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.1 9.4 GO:0008083 growth factor activity(GO:0008083)
0.1 0.7 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.1 0.5 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.1 0.6 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 2.0 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 7.2 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 1.3 GO:0001968 fibronectin binding(GO:0001968)
0.1 0.7 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 10.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 2.0 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 0.3 GO:0016401 palmitoyl-CoA oxidase activity(GO:0016401)
0.0 0.2 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.0 0.8 GO:0030553 cGMP binding(GO:0030553)
0.0 0.2 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 1.9 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 1.0 GO:0035250 UDP-galactosyltransferase activity(GO:0035250)
0.0 0.3 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.0 0.3 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0 0.9 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.8 GO:0035613 RNA stem-loop binding(GO:0035613)
0.0 0.5 GO:0043274 phospholipase binding(GO:0043274)
0.0 0.3 GO:0045125 bioactive lipid receptor activity(GO:0045125)
0.0 1.3 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 1.6 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0 1.2 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0 0.4 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 2.8 GO:0017124 SH3 domain binding(GO:0017124)
0.0 2.9 GO:0044325 ion channel binding(GO:0044325)
0.0 4.6 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 1.3 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 5.4 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 5.4 PID_EPO_PATHWAY EPO signaling pathway
0.1 7.2 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 3.3 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 0.5 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.1 2.6 PID_AVB3_OPN_PATHWAY Osteopontin-mediated events
0.1 2.7 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 0.8 PID_CONE_PATHWAY Visual signal transduction: Cones
0.1 1.6 PID_TCPTP_PATHWAY Signaling events mediated by TCPTP
0.1 8.4 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.1 4.5 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 3.9 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.4 PID_BCR_5PATHWAY BCR signaling pathway
0.0 0.6 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 2.1 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 0.9 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.0 0.2 PID_IL23_PATHWAY IL23-mediated signaling events
0.0 0.8 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.5 PID_TCR_PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.8 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.3 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.3 1.4 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.3 5.4 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.1 2.0 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 4.0 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 2.7 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 7.2 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 1.3 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.1 2.1 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 0.9 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.6 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 1.2 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 3.6 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 1.6 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 2.9 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 2.1 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.7 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 0.9 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.6 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.3 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.5 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.7 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.3 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 1.0 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.0 1.1 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes