Motif ID: Atf4

Z-value: 0.707


Transcription factors associated with Atf4:

Gene SymbolEntrez IDGene Name
Atf4 ENSMUSG00000042406.7 Atf4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Atf4mm10_v2_chr15_+_80255184_802552630.491.3e-03Click!


Activity profile for motif Atf4.

activity profile for motif Atf4


Sorted Z-values histogram for motif Atf4

Sorted Z-values for motif Atf4



Network of associatons between targets according to the STRING database.



First level regulatory network of Atf4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_23248264 7.373 ENSMUST00000031709.5
Fezf1
Fez family zinc finger 1
chr7_+_144896523 4.779 ENSMUST00000033389.5
Fgf15
fibroblast growth factor 15
chr1_-_71653162 4.184 ENSMUST00000055226.6
Fn1
fibronectin 1
chr4_+_43957678 3.336 ENSMUST00000107855.1
Glipr2
GLI pathogenesis-related 2
chrX_+_103422010 3.316 ENSMUST00000182089.1
Gm26992
predicted gene, 26992
chr2_+_119351222 2.941 ENSMUST00000028780.3
Chac1
ChaC, cation transport regulator 1
chr13_+_49682191 2.201 ENSMUST00000172254.1
Iars
isoleucine-tRNA synthetase
chr4_+_46450892 1.881 ENSMUST00000102926.4
Anp32b
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr5_+_93093428 1.757 ENSMUST00000074733.7
Sept11
septin 11
chr4_-_129189600 1.692 ENSMUST00000117497.1
ENSMUST00000117350.1
S100pbp

S100P binding protein

chr19_-_12501996 1.624 ENSMUST00000045521.7
Dtx4
deltex 4 homolog (Drosophila)
chr8_+_75093591 1.520 ENSMUST00000005548.6
Hmox1
heme oxygenase (decycling) 1
chr19_+_53140430 1.511 ENSMUST00000111741.2
Add3
adducin 3 (gamma)
chr13_+_49682100 1.436 ENSMUST00000165316.1
ENSMUST00000047363.7
Iars

isoleucine-tRNA synthetase

chr4_-_129189512 1.419 ENSMUST00000117965.1
ENSMUST00000106061.2
ENSMUST00000072431.6
S100pbp


S100P binding protein


chr11_+_100320596 1.394 ENSMUST00000152521.1
Eif1
eukaryotic translation initiation factor 1
chr4_-_129189646 1.387 ENSMUST00000106059.1
S100pbp
S100P binding protein
chrX_+_106187100 1.386 ENSMUST00000081593.6
Pgk1
phosphoglycerate kinase 1
chr3_-_138143352 1.338 ENSMUST00000098580.2
Mttp
microsomal triglyceride transfer protein
chr14_+_63436394 1.298 ENSMUST00000121288.1
Fam167a
family with sequence similarity 167, member A
chr6_-_83317589 1.065 ENSMUST00000005810.6
Mthfd2
methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase
chr19_-_15924928 1.051 ENSMUST00000025542.3
Psat1
phosphoserine aminotransferase 1
chr4_+_117835387 1.036 ENSMUST00000169885.1
Slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr12_-_108893197 1.020 ENSMUST00000161154.1
ENSMUST00000161410.1
Wars

tryptophanyl-tRNA synthetase

chr13_-_53473074 1.015 ENSMUST00000021922.8
Msx2
msh homeobox 2
chr19_+_44203265 0.976 ENSMUST00000026220.5
Scd3
stearoyl-coenzyme A desaturase 3
chr2_-_18048784 0.945 ENSMUST00000142856.1
Skida1
SKI/DACH domain containing 1
chr8_+_111033890 0.783 ENSMUST00000034441.7
Aars
alanyl-tRNA synthetase
chr13_-_30545254 0.779 ENSMUST00000042834.3
Uqcrfs1
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
chr10_-_127522428 0.754 ENSMUST00000026470.4
Shmt2
serine hydroxymethyltransferase 2 (mitochondrial)
chr2_-_18048347 0.736 ENSMUST00000066885.5
Skida1
SKI/DACH domain containing 1
chr6_+_55037988 0.727 ENSMUST00000003572.8
Gars
glycyl-tRNA synthetase
chr5_-_145140238 0.723 ENSMUST00000031627.8
Pdap1
PDGFA associated protein 1
chr11_-_98400393 0.683 ENSMUST00000128897.1
Pgap3
post-GPI attachment to proteins 3
chr10_-_121626316 0.666 ENSMUST00000039810.7
Xpot
exportin, tRNA (nuclear export receptor for tRNAs)
chr5_-_31179901 0.645 ENSMUST00000101411.2
ENSMUST00000140793.1
Gtf3c2

general transcription factor IIIC, polypeptide 2, beta

chr11_-_98400453 0.633 ENSMUST00000090827.5
Pgap3
post-GPI attachment to proteins 3
chr14_-_54870913 0.622 ENSMUST00000146642.1
Homez
homeodomain leucine zipper-encoding gene
chr15_+_99393610 0.597 ENSMUST00000159531.1
Tmbim6
transmembrane BAX inhibitor motif containing 6
chr19_-_43524462 0.597 ENSMUST00000026196.7
Got1
glutamate oxaloacetate transaminase 1, soluble
chr18_-_42262053 0.568 ENSMUST00000097590.3
Lars
leucyl-tRNA synthetase
chr7_+_126565919 0.534 ENSMUST00000180459.1
G730046D07Rik
RIKEN cDNA G730046D07 gene
chr7_-_126566364 0.512 ENSMUST00000032992.5
Eif3c
eukaryotic translation initiation factor 3, subunit C
chr8_+_117157972 0.505 ENSMUST00000064488.4
ENSMUST00000162997.1
Gan

giant axonal neuropathy

chr15_+_99393574 0.496 ENSMUST00000162624.1
Tmbim6
transmembrane BAX inhibitor motif containing 6
chr3_+_138143429 0.493 ENSMUST00000040321.6
Trmt10a
tRNA methyltransferase 10A
chr12_+_85599047 0.486 ENSMUST00000177587.1
Jdp2
Jun dimerization protein 2
chr5_-_148399901 0.470 ENSMUST00000048116.8
Slc7a1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr2_+_163995503 0.453 ENSMUST00000131288.1
Ywhab
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
chr1_+_133131143 0.442 ENSMUST00000052529.3
Ppp1r15b
protein phosphatase 1, regulatory (inhibitor) subunit 15b
chr3_-_89998656 0.437 ENSMUST00000079724.4
Hax1
HCLS1 associated X-1
chr3_+_138143888 0.436 ENSMUST00000161141.1
Trmt10a
tRNA methyltransferase 10A
chr5_-_31180110 0.407 ENSMUST00000043161.6
ENSMUST00000088010.5
Gtf3c2

general transcription factor IIIC, polypeptide 2, beta

chr15_+_99393219 0.394 ENSMUST00000159209.1
Tmbim6
transmembrane BAX inhibitor motif containing 6
chr12_+_85599388 0.370 ENSMUST00000050687.6
Jdp2
Jun dimerization protein 2
chr19_-_40588374 0.367 ENSMUST00000175932.1
ENSMUST00000176955.1
ENSMUST00000149476.2
Aldh18a1


aldehyde dehydrogenase 18 family, member A1


chr11_-_101171302 0.350 ENSMUST00000164474.1
ENSMUST00000043397.7
Plekhh3

pleckstrin homology domain containing, family H (with MyTH4 domain) member 3

chr11_-_53430417 0.347 ENSMUST00000109019.1
Uqcrq
ubiquinol-cytochrome c reductase, complex III subunit VII
chr10_+_102158858 0.341 ENSMUST00000138522.1
ENSMUST00000163753.1
ENSMUST00000138016.1
Mgat4c


mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)


chr3_+_138143483 0.338 ENSMUST00000162864.1
Trmt10a
tRNA methyltransferase 10A
chr5_+_145140362 0.327 ENSMUST00000162594.1
ENSMUST00000162308.1
ENSMUST00000159018.1
ENSMUST00000160075.1
Bud31



BUD31 homolog (yeast)



chr1_-_78488846 0.326 ENSMUST00000068333.7
ENSMUST00000170217.1
Farsb

phenylalanyl-tRNA synthetase, beta subunit

chr2_-_3512746 0.317 ENSMUST00000027961.5
ENSMUST00000056700.7
Hspa14
Hspa14
heat shock protein 14
heat shock protein 14
chr2_+_119047116 0.312 ENSMUST00000152380.1
ENSMUST00000099542.2
Casc5

cancer susceptibility candidate 5

chr19_-_4793851 0.308 ENSMUST00000178615.1
ENSMUST00000179189.1
ENSMUST00000164376.2
ENSMUST00000164209.2
ENSMUST00000180248.1
Rbm4




RNA binding motif protein 4




chr2_+_119047129 0.301 ENSMUST00000153300.1
ENSMUST00000028799.5
Casc5

cancer susceptibility candidate 5

chr13_-_118387224 0.299 ENSMUST00000022245.8
Mrps30
mitochondrial ribosomal protein S30
chr7_-_126502094 0.294 ENSMUST00000179818.1
Atxn2l
ataxin 2-like
chr17_-_34187219 0.282 ENSMUST00000173831.1
Psmb9
proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
chr19_-_50678642 0.281 ENSMUST00000072685.6
ENSMUST00000164039.2
Sorcs1

VPS10 domain receptor protein SORCS 1

chr10_-_127311740 0.264 ENSMUST00000037290.5
ENSMUST00000171564.1
Mars

methionine-tRNA synthetase

chr9_+_109931774 0.259 ENSMUST00000169851.2
Map4
microtubule-associated protein 4
chr14_-_69284982 0.207 ENSMUST00000183882.1
ENSMUST00000037064.4
Slc25a37

solute carrier family 25, member 37

chr15_-_83510793 0.206 ENSMUST00000154401.1
Ttll1
tubulin tyrosine ligase-like 1
chr10_+_96616998 0.201 ENSMUST00000038377.7
Btg1
B cell translocation gene 1, anti-proliferative
chr8_-_92356103 0.186 ENSMUST00000034183.3
4933436C20Rik
RIKEN cDNA 4933436C20 gene
chr15_-_83510861 0.183 ENSMUST00000109479.1
ENSMUST00000109480.1
ENSMUST00000016897.4
Ttll1


tubulin tyrosine ligase-like 1


chr15_-_98953541 0.176 ENSMUST00000097014.5
Tuba1a
tubulin, alpha 1A
chr4_+_42735545 0.175 ENSMUST00000068158.3
4930578G10Rik
RIKEN cDNA 4930578G10 gene
chr8_+_123477859 0.156 ENSMUST00000001520.7
Afg3l1
AFG3(ATPase family gene 3)-like 1 (yeast)
chr4_+_129189760 0.134 ENSMUST00000106054.2
ENSMUST00000001365.2
Yars

tyrosyl-tRNA synthetase

chr19_-_40588338 0.131 ENSMUST00000176939.1
Aldh18a1
aldehyde dehydrogenase 18 family, member A1
chr11_-_53430779 0.118 ENSMUST00000061326.4
ENSMUST00000109021.3
Uqcrq

ubiquinol-cytochrome c reductase, complex III subunit VII

chr8_+_85492568 0.117 ENSMUST00000034136.5
Gpt2
glutamic pyruvate transaminase (alanine aminotransferase) 2
chr19_-_40588453 0.116 ENSMUST00000025979.6
Aldh18a1
aldehyde dehydrogenase 18 family, member A1
chr5_-_90223923 0.101 ENSMUST00000118816.1
ENSMUST00000048363.7
Cox18

cytochrome c oxidase assembly protein 18

chr1_-_191183244 0.099 ENSMUST00000027941.8
Atf3
activating transcription factor 3
chr4_+_127021311 0.087 ENSMUST00000030623.7
Sfpq
splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)
chr11_-_118290167 0.072 ENSMUST00000144153.1
Usp36
ubiquitin specific peptidase 36
chr15_+_82147238 0.067 ENSMUST00000023100.6
Srebf2
sterol regulatory element binding factor 2
chr18_-_64516547 0.061 ENSMUST00000025483.9
Nars
asparaginyl-tRNA synthetase
chr10_+_80141457 0.054 ENSMUST00000105367.1
Atp5d
ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
chr14_-_37135126 0.051 ENSMUST00000042564.9
Ghitm
growth hormone inducible transmembrane protein
chr7_-_126502312 0.046 ENSMUST00000166682.2
Atxn2l
ataxin 2-like
chr3_+_88616133 0.039 ENSMUST00000176500.1
ENSMUST00000177498.1
Arhgef2

rho/rac guanine nucleotide exchange factor (GEF) 2

chr4_-_108833608 0.027 ENSMUST00000102742.4
Btf3l4
basic transcription factor 3-like 4
chr17_+_34187545 0.019 ENSMUST00000170086.1
Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr1_-_36709904 0.018 ENSMUST00000043951.3
Actr1b
ARP1 actin-related protein 1B, centractin beta
chr11_-_75422524 0.012 ENSMUST00000125982.1
ENSMUST00000137103.1
Serpinf1

serine (or cysteine) peptidase inhibitor, clade F, member 1

chr3_+_138143846 0.012 ENSMUST00000159481.1
Trmt10a
tRNA methyltransferase 10A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.2 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931) calcium-independent cell-matrix adhesion(GO:0007161) transforming growth factor-beta secretion(GO:0038044)
1.2 7.4 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.2 3.6 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
1.2 4.8 GO:0070858 negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252)
0.7 2.9 GO:0006751 glutathione catabolic process(GO:0006751)
0.4 1.5 GO:1904706 heme oxidation(GO:0006788) negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
0.4 1.8 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.3 1.0 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.3 1.0 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.3 1.0 GO:0035880 embryonic nail plate morphogenesis(GO:0035880) positive regulation of catagen(GO:0051795) frontal suture morphogenesis(GO:0060364)
0.3 1.5 GO:1904721 regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.3 1.3 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.3 0.8 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.2 1.0 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.2 0.6 GO:0006592 ornithine biosynthetic process(GO:0006592)
0.2 0.6 GO:0006106 fumarate metabolic process(GO:0006106) aspartate biosynthetic process(GO:0006532) aspartate catabolic process(GO:0006533) alditol biosynthetic process(GO:0019401)
0.2 0.7 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.1 0.7 GO:0015960 diadenosine polyphosphate biosynthetic process(GO:0015960) diadenosine tetraphosphate metabolic process(GO:0015965) diadenosine tetraphosphate biosynthetic process(GO:0015966)
0.1 0.6 GO:0006438 valyl-tRNA aminoacylation(GO:0006438)
0.1 1.4 GO:0031639 plasminogen activation(GO:0031639)
0.1 1.4 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.1 1.9 GO:0043486 histone exchange(GO:0043486)
0.1 0.3 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.1 0.5 GO:0021539 subthalamus development(GO:0021539)
0.1 0.4 GO:1903912 negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:1903912)
0.1 0.1 GO:0072368 regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter(GO:0072368)
0.1 0.4 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.1 0.3 GO:0097167 circadian regulation of translation(GO:0097167)
0.1 3.3 GO:0010718 positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.1 0.5 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.0 0.4 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 1.0 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.0 0.2 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.0 0.5 GO:0015809 arginine transport(GO:0015809)
0.0 0.9 GO:0031065 positive regulation of histone deacetylation(GO:0031065)
0.0 1.3 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 1.1 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.0 0.3 GO:1901838 positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838)
0.0 0.1 GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.0 0.1 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.0 0.3 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.0 0.1 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.0 0.1 GO:0051204 protein insertion into mitochondrial membrane(GO:0051204)
0.0 0.2 GO:0034982 mitochondrial protein processing(GO:0034982)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.2 GO:0005577 fibrinogen complex(GO:0005577)
0.3 4.2 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.2 0.8 GO:0070552 BRISC complex(GO:0070552)
0.1 1.1 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.1 1.2 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.1 0.3 GO:0009328 phenylalanine-tRNA ligase complex(GO:0009328)
0.1 1.3 GO:0031528 microvillus membrane(GO:0031528)
0.1 0.3 GO:1990111 spermatoproteasome complex(GO:1990111)
0.1 0.5 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0 0.2 GO:0005745 m-AAA complex(GO:0005745)
0.0 0.4 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 1.5 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 1.8 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 5.8 GO:0016607 nuclear speck(GO:0016607)
0.0 0.1 GO:0042382 paraspeckles(GO:0042382)
0.0 1.5 GO:0005901 caveola(GO:0005901)
0.0 3.3 GO:0000139 Golgi membrane(GO:0000139)
0.0 2.9 GO:0005802 trans-Golgi network(GO:0005802)
0.0 1.4 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.6 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.7 4.2 GO:0045340 mercury ion binding(GO:0045340)
0.6 2.9 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.5 2.0 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.4 1.5 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.4 1.1 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.3 1.0 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.3 0.8 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.3 0.8 GO:0008732 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.2 1.5 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.2 1.0 GO:0032896 palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.2 4.8 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.2 0.6 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.2 1.2 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 0.4 GO:0019966 interleukin-1 binding(GO:0019966)
0.1 0.6 GO:0004832 valine-tRNA ligase activity(GO:0004832)
0.1 1.0 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.1 1.0 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.1 0.4 GO:0070740 tubulin-glutamic acid ligase activity(GO:0070740)
0.1 1.2 GO:0008483 transaminase activity(GO:0008483)
0.1 0.3 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1 0.3 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.1 0.5 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.1 1.3 GO:0034185 apolipoprotein binding(GO:0034185)
0.1 4.5 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.7 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 8.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.5 GO:0050815 phosphoserine binding(GO:0050815)
0.0 0.7 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.0 1.9 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.3 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.0 1.0 GO:0000049 tRNA binding(GO:0000049)
0.0 0.1 GO:0004816 asparagine-tRNA ligase activity(GO:0004816)
0.0 0.2 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
0.0 0.3 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) proteasome binding(GO:0070628)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.2 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 3.6 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.0 1.5 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.4 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.5 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.2 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.2 7.0 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 1.0 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 1.3 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 1.7 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 1.4 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 1.6 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 1.1 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_2_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.0 1.4 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.0 0.5 REACTOME_RAF_MAP_KINASE_CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.3 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 1.2 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 0.2 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.6 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere