Motif ID: Smad3

Z-value: 0.742


Transcription factors associated with Smad3:

Gene SymbolEntrez IDGene Name
Smad3 ENSMUSG00000032402.6 Smad3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad3mm10_v2_chr9_-_63757933_637579940.662.2e-06Click!


Activity profile for motif Smad3.

activity profile for motif Smad3


Sorted Z-values histogram for motif Smad3

Sorted Z-values for motif Smad3



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_53707532 7.698 ENSMUST00000031093.3
Cckar
cholecystokinin A receptor
chr13_+_23533869 3.818 ENSMUST00000073261.2
Hist1h2af
histone cluster 1, H2af
chr13_-_21750505 3.674 ENSMUST00000102983.1
Hist1h4k
histone cluster 1, H4k
chr13_-_21832194 3.658 ENSMUST00000102979.1
Hist1h4n
histone cluster 1, H4n
chr13_-_23551648 3.520 ENSMUST00000102971.1
Hist1h4f
histone cluster 1, H4f
chr18_-_77047243 3.333 ENSMUST00000137354.1
ENSMUST00000137498.1
Katnal2

katanin p60 subunit A-like 2

chr13_+_23531044 3.231 ENSMUST00000102972.3
Hist1h4h
histone cluster 1, H4h
chr18_-_74207771 2.775 ENSMUST00000040188.8
ENSMUST00000177604.1
Ska1

spindle and kinetochore associated complex subunit 1

chr6_-_72235559 2.748 ENSMUST00000042646.7
Atoh8
atonal homolog 8 (Drosophila)
chr13_-_22042949 2.634 ENSMUST00000091741.4
Hist1h2ag
histone cluster 1, H2ag
chr13_+_23581563 2.604 ENSMUST00000102968.1
Hist1h4d
histone cluster 1, H4d
chr18_-_77047282 2.539 ENSMUST00000154665.1
ENSMUST00000026486.6
ENSMUST00000123650.1
ENSMUST00000126153.1
Katnal2



katanin p60 subunit A-like 2



chr13_-_21833575 2.458 ENSMUST00000081342.5
Hist1h2ap
histone cluster 1, H2ap
chr13_+_22043189 2.387 ENSMUST00000110452.1
Hist1h2bj
histone cluster 1, H2bj
chr2_-_163750169 2.291 ENSMUST00000017841.3
Ada
adenosine deaminase
chr13_-_23571151 2.247 ENSMUST00000102969.3
Hist1h2ae
histone cluster 1, H2ae
chr13_+_22035821 2.046 ENSMUST00000110455.2
Hist1h2bk
histone cluster 1, H2bk
chr13_+_21735055 1.867 ENSMUST00000087714.4
Hist1h4j
histone cluster 1, H4j
chr13_+_21810428 1.790 ENSMUST00000091745.5
Hist1h2ao
histone cluster 1, H2ao
chr13_+_92354783 1.782 ENSMUST00000022218.4
Dhfr
dihydrofolate reductase
chr9_-_66514567 1.740 ENSMUST00000056890.8
Fbxl22
F-box and leucine-rich repeat protein 22
chr13_-_22035589 1.713 ENSMUST00000091742.4
Hist1h2ah
histone cluster 1, H2ah
chr17_-_31277327 1.606 ENSMUST00000024832.7
Rsph1
radial spoke head 1 homolog (Chlamydomonas)
chr13_+_21833736 1.399 ENSMUST00000180288.1
ENSMUST00000110467.1
Hist1h2br

histone cluster 1 H2br

chr11_-_26591729 1.396 ENSMUST00000109504.1
Vrk2
vaccinia related kinase 2
chr9_+_69454066 1.390 ENSMUST00000134907.1
Anxa2
annexin A2
chr13_+_23746734 1.315 ENSMUST00000099703.2
Hist1h2bb
histone cluster 1, H2bb
chr12_+_12911986 1.310 ENSMUST00000085720.1
Rpl36-ps3
ribosomal protein L36, pseudogene 3
chr9_+_109038565 1.297 ENSMUST00000112059.3
ENSMUST00000026737.5
Shisa5

shisa homolog 5 (Xenopus laevis)

chr2_-_127143410 1.242 ENSMUST00000132773.1
Itpripl1
inositol 1,4,5-triphosphate receptor interacting protein-like 1
chr9_+_53771499 1.176 ENSMUST00000048670.8
Slc35f2
solute carrier family 35, member F2
chr1_+_146497614 1.173 ENSMUST00000132847.1
ENSMUST00000166814.1
Brinp3

bone morphogenetic protein/retinoic acid inducible neural specific 3

chr3_+_102734496 1.156 ENSMUST00000029451.5
Tspan2
tetraspanin 2
chr13_-_21787218 1.155 ENSMUST00000091751.2
Hist1h2an
histone cluster 1, H2an
chrX_+_105079761 1.141 ENSMUST00000119477.1
Pbdc1
polysaccharide biosynthesis domain containing 1
chr13_+_23571382 1.093 ENSMUST00000079251.5
Hist1h2bg
histone cluster 1, H2bg
chr13_+_23684192 1.076 ENSMUST00000018246.4
Hist1h2bc
histone cluster 1, H2bc
chr13_-_21810190 1.039 ENSMUST00000110469.1
ENSMUST00000091749.2
Hist1h2bq

histone cluster 1, H2bq

chr14_-_62456286 1.022 ENSMUST00000165651.1
ENSMUST00000022501.3
Gucy1b2

guanylate cyclase 1, soluble, beta 2

chr7_+_137437591 0.976 ENSMUST00000064404.6
Glrx3
glutaredoxin 3
chr7_-_45052865 0.900 ENSMUST00000057293.6
Prr12
proline rich 12
chr13_+_21787461 0.873 ENSMUST00000110473.2
ENSMUST00000102982.1
Hist1h2bp

histone cluster 1, H2bp

chr1_-_21079162 0.859 ENSMUST00000037998.4
Tram2
translocating chain-associating membrane protein 2
chr19_-_47919269 0.753 ENSMUST00000095998.5
Itprip
inositol 1,4,5-triphosphate receptor interacting protein
chr1_-_126492683 0.694 ENSMUST00000162877.1
Nckap5
NCK-associated protein 5
chr6_+_136808248 0.684 ENSMUST00000074556.4
H2afj
H2A histone family, member J
chr3_+_107631322 0.671 ENSMUST00000106703.1
Gm10961
predicted gene 10961
chr4_+_45018583 0.664 ENSMUST00000133157.1
ENSMUST00000029999.8
ENSMUST00000107814.3
Polr1e


polymerase (RNA) I polypeptide E


chr14_-_49783327 0.656 ENSMUST00000118129.1
ENSMUST00000036972.6
3632451O06Rik

RIKEN cDNA 3632451O06 gene

chrX_+_143664290 0.612 ENSMUST00000112868.1
Pak3
p21 protein (Cdc42/Rac)-activated kinase 3
chrX_+_153832225 0.608 ENSMUST00000148708.1
ENSMUST00000123264.1
ENSMUST00000049999.8
Spin2c


spindlin family, member 2C


chr1_+_75210832 0.573 ENSMUST00000027401.4
ENSMUST00000144355.1
ENSMUST00000123825.1
Stk16


serine/threonine kinase 16


chr4_+_130055010 0.552 ENSMUST00000123617.1
Col16a1
collagen, type XVI, alpha 1
chr11_-_87828289 0.547 ENSMUST00000136446.1
Lpo
lactoperoxidase
chr13_-_23683941 0.520 ENSMUST00000171127.1
Hist1h2ac
histone cluster 1, H2ac
chr4_+_95557494 0.512 ENSMUST00000079223.4
ENSMUST00000177394.1
Fggy

FGGY carbohydrate kinase domain containing

chr7_+_82867327 0.483 ENSMUST00000082237.5
Mex3b
mex3 homolog B (C. elegans)
chr10_+_33905015 0.462 ENSMUST00000169670.1
Rsph4a
radial spoke head 4 homolog A (Chlamydomonas)
chr1_-_143702832 0.428 ENSMUST00000018337.7
Cdc73
cell division cycle 73, Paf1/RNA polymerase II complex component
chr9_+_21196705 0.410 ENSMUST00000003395.9
Pde4a
phosphodiesterase 4A, cAMP specific
chr19_-_23448322 0.286 ENSMUST00000036069.6
Mamdc2
MAM domain containing 2
chr12_+_100779074 0.271 ENSMUST00000110073.1
ENSMUST00000110070.1
9030617O03Rik

RIKEN cDNA 9030617O03 gene

chrX_+_143664365 0.242 ENSMUST00000126592.1
ENSMUST00000156449.1
ENSMUST00000155215.1
ENSMUST00000112865.1
Pak3



p21 protein (Cdc42/Rac)-activated kinase 3



chr9_+_44072196 0.230 ENSMUST00000176671.1
Usp2
ubiquitin specific peptidase 2
chr15_-_58823530 0.217 ENSMUST00000072113.5
Tmem65
transmembrane protein 65
chr5_-_116422858 0.217 ENSMUST00000036991.4
Hspb8
heat shock protein 8
chr15_-_76209056 0.161 ENSMUST00000071869.5
ENSMUST00000170915.1
Plec

plectin

chr19_+_55898553 0.132 ENSMUST00000148666.1
Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr7_-_44236098 0.126 ENSMUST00000037220.4
1700028J19Rik
RIKEN cDNA 1700028J19 gene
chr1_-_126492900 0.101 ENSMUST00000161954.1
Nckap5
NCK-associated protein 5
chr6_-_129533267 0.099 ENSMUST00000181594.1
1700101I11Rik
RIKEN cDNA 1700101I11 gene
chr11_+_46436925 0.089 ENSMUST00000152119.1
ENSMUST00000140027.1
ENSMUST00000020665.6
ENSMUST00000170928.1
ENSMUST00000109231.1
ENSMUST00000109232.3
ENSMUST00000128940.1
Med7






mediator complex subunit 7






chr9_-_66593106 0.085 ENSMUST00000127569.1
Usp3
ubiquitin specific peptidase 3
chr14_+_20348159 0.048 ENSMUST00000090503.4
ENSMUST00000090499.5
ENSMUST00000037698.5
ENSMUST00000051915.6
Fam149b



family with sequence similarity 149, member B



chr7_-_127588595 0.044 ENSMUST00000072155.3
Gm166
predicted gene 166
chr2_+_29869484 0.021 ENSMUST00000047521.6
ENSMUST00000134152.1
Cercam

cerebral endothelial cell adhesion molecule

chrX_-_95026671 0.019 ENSMUST00000096367.3
Spin4
spindlin family, member 4
chrX_-_144688180 0.015 ENSMUST00000040184.3
Trpc5
transient receptor potential cation channel, subfamily C, member 5
chr12_-_12941827 0.013 ENSMUST00000043396.7
Mycn
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 7.7 GO:0090274 positive regulation of somatostatin secretion(GO:0090274)
1.0 18.6 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.8 2.3 GO:0002314 germinal center B cell differentiation(GO:0002314) positive regulation of germinal center formation(GO:0002636) adenosine catabolic process(GO:0006154) purine nucleobase salvage(GO:0043096) hypoxanthine metabolic process(GO:0046100) hypoxanthine biosynthetic process(GO:0046101) xanthine metabolic process(GO:0046110) purine deoxyribonucleoside metabolic process(GO:0046122) regulation of adenosine receptor signaling pathway(GO:0060167)
0.5 1.4 GO:2000659 regulation of interleukin-1-mediated signaling pathway(GO:2000659)
0.4 1.8 GO:0046655 glycine biosynthetic process(GO:0006545) folic acid metabolic process(GO:0046655)
0.4 4.2 GO:0002227 innate immune response in mucosa(GO:0002227)
0.3 1.2 GO:0014005 microglia differentiation(GO:0014004) microglia development(GO:0014005)
0.3 1.4 GO:0052428 modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
0.2 0.7 GO:0001180 transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript(GO:0001180)
0.2 0.5 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.2 2.7 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.1 1.0 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.1 13.8 GO:0006342 chromatin silencing(GO:0006342)
0.1 0.9 GO:0045048 protein insertion into ER membrane(GO:0045048)
0.1 0.5 GO:0072697 protein localization to cell cortex(GO:0072697)
0.0 4.6 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.5 GO:0019321 pentose metabolic process(GO:0019321)
0.0 0.2 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.3 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.9 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.0 0.4 GO:0001711 endodermal cell fate commitment(GO:0001711)
0.0 1.4 GO:0035082 axoneme assembly(GO:0035082)
0.0 1.0 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.0 1.2 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 2.8 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.0 0.6 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894)
0.0 0.1 GO:0010908 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334)
0.0 0.4 GO:0043949 regulation of cAMP-mediated signaling(GO:0043949)
0.0 0.2 GO:0048643 locomotor rhythm(GO:0045475) positive regulation of skeletal muscle tissue development(GO:0048643)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.4 14.1 GO:0000788 nuclear nucleosome(GO:0000788)
0.4 14.1 GO:0000786 nucleosome(GO:0000786)
0.2 2.8 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.2 1.6 GO:0001520 outer dense fiber(GO:0001520)
0.1 1.0 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 1.9 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 6.6 GO:0043195 terminal bouton(GO:0043195)
0.0 0.4 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.7 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 1.7 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.3 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.2 GO:0030056 hemidesmosome(GO:0030056)
0.0 6.6 GO:0000790 nuclear chromatin(GO:0000790)
0.0 5.4 GO:0005874 microtubule(GO:0005874)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 5.9 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.6 1.8 GO:0051870 methotrexate binding(GO:0051870)
0.3 1.4 GO:0004859 phospholipase inhibitor activity(GO:0004859) phospholipase A2 inhibitor activity(GO:0019834)
0.2 2.3 GO:0004000 adenosine deaminase activity(GO:0004000)
0.1 7.7 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.1 0.7 GO:0001179 RNA polymerase I transcription factor binding(GO:0001179)
0.1 17.5 GO:0042393 histone binding(GO:0042393)
0.1 2.7 GO:0070888 E-box binding(GO:0070888)
0.1 1.0 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 1.0 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.0 0.9 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.5 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.5 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.0 0.4 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.6 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.5 GO:0004601 peroxidase activity(GO:0004601)
0.0 7.2 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 0.1 GO:0045295 gamma-catenin binding(GO:0045295)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.3 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.8 PID_E2F_PATHWAY E2F transcription factor network
0.0 0.9 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.6 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 25.6 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.1 2.3 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.1 1.8 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.1 7.7 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 2.8 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase