Motif ID: Nkx2-9

Z-value: 0.912


Transcription factors associated with Nkx2-9:

Gene SymbolEntrez IDGene Name
Nkx2-9 ENSMUSG00000058669.7 Nkx2-9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-9mm10_v2_chr12_-_56613270_566132910.144.0e-01Click!


Activity profile for motif Nkx2-9.

activity profile for motif Nkx2-9


Sorted Z-values histogram for motif Nkx2-9

Sorted Z-values for motif Nkx2-9



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-9

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_+_30065333 10.147 ENSMUST00000023171.7
Hes1
hairy and enhancer of split 1 (Drosophila)
chr9_+_57504012 8.214 ENSMUST00000080514.7
Rpp25
ribonuclease P/MRP 25 subunit
chr15_-_88978958 7.002 ENSMUST00000042594.6
ENSMUST00000109368.1
Mlc1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

chr6_+_135362931 6.199 ENSMUST00000032330.9
Emp1
epithelial membrane protein 1
chr8_-_46294592 5.835 ENSMUST00000058636.7
Helt
helt bHLH transcription factor
chr12_-_56536895 5.558 ENSMUST00000001536.8
Nkx2-1
NK2 homeobox 1
chr2_+_20737306 5.079 ENSMUST00000114606.1
ENSMUST00000114608.1
Etl4

enhancer trap locus 4

chr11_+_117849223 4.879 ENSMUST00000081387.4
Birc5
baculoviral IAP repeat-containing 5
chr10_+_88091070 4.479 ENSMUST00000048621.7
Pmch
pro-melanin-concentrating hormone
chr11_+_117849286 3.969 ENSMUST00000093906.4
Birc5
baculoviral IAP repeat-containing 5
chr7_-_142576492 3.423 ENSMUST00000140716.1
H19
H19 fetal liver mRNA
chr18_+_77185815 3.343 ENSMUST00000079618.4
St8sia5
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
chr11_+_88718442 3.262 ENSMUST00000138007.1
C030037D09Rik
RIKEN cDNA C030037D09 gene
chr3_+_122419772 3.220 ENSMUST00000029766.4
Bcar3
breast cancer anti-estrogen resistance 3
chr2_+_173022360 3.167 ENSMUST00000173997.1
Rbm38
RNA binding motif protein 38
chr16_-_33380717 3.044 ENSMUST00000180923.1
1700007L15Rik
RIKEN cDNA 1700007L15 gene
chr6_-_6217023 2.821 ENSMUST00000015256.8
Slc25a13
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13
chr8_+_95633500 2.817 ENSMUST00000034094.9
Gins3
GINS complex subunit 3 (Psf3 homolog)
chr6_+_66896397 2.571 ENSMUST00000043148.6
ENSMUST00000114228.1
ENSMUST00000114227.1
ENSMUST00000114226.1
ENSMUST00000114225.1
ENSMUST00000114224.1
Gng12





guanine nucleotide binding protein (G protein), gamma 12





chrX_+_56779437 2.489 ENSMUST00000114773.3
Fhl1
four and a half LIM domains 1
chr5_-_45639501 2.459 ENSMUST00000016023.7
Fam184b
family with sequence similarity 184, member B
chr10_+_94198955 2.249 ENSMUST00000020209.9
ENSMUST00000179990.1
Ndufa12

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12

chr16_-_35490873 2.236 ENSMUST00000023550.7
Pdia5
protein disulfide isomerase associated 5
chr1_-_128103016 2.193 ENSMUST00000097597.2
Zranb3
zinc finger, RAN-binding domain containing 3
chr17_+_46496753 2.169 ENSMUST00000046497.6
Dnph1
2'-deoxynucleoside 5'-phosphate N-hydrolase 1
chr14_+_75455957 2.166 ENSMUST00000164848.1
Siah3
seven in absentia homolog 3 (Drosophila)
chr1_-_181842334 2.149 ENSMUST00000005003.6
Lbr
lamin B receptor
chr9_-_54647199 2.098 ENSMUST00000128163.1
Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr16_-_46155077 1.723 ENSMUST00000059524.5
Gm4737
predicted gene 4737
chr17_-_25861456 1.692 ENSMUST00000079461.8
ENSMUST00000176923.1
Wdr90

WD repeat domain 90

chr3_-_95411176 1.678 ENSMUST00000177599.1
Gm5070
predicted gene 5070
chrX_-_102189371 1.545 ENSMUST00000033683.7
Rps4x
ribosomal protein S4, X-linked
chr6_-_101377342 1.543 ENSMUST00000151175.1
Pdzrn3
PDZ domain containing RING finger 3
chr10_-_59221757 1.536 ENSMUST00000165971.1
Sept10
septin 10
chr1_+_87264345 1.511 ENSMUST00000118687.1
ENSMUST00000027472.6
Efhd1

EF hand domain containing 1

chr13_-_51567084 1.471 ENSMUST00000021898.5
Shc3
src homology 2 domain-containing transforming protein C3
chr13_-_71963713 1.378 ENSMUST00000077337.8
Irx1
Iroquois related homeobox 1 (Drosophila)
chr16_-_76403673 1.375 ENSMUST00000052867.7
Gm9843
predicted gene 9843
chr6_+_66896480 1.365 ENSMUST00000114222.1
Gng12
guanine nucleotide binding protein (G protein), gamma 12
chr4_-_72852622 1.349 ENSMUST00000179234.1
ENSMUST00000078617.4
Aldoart1

aldolase 1 A, retrogene 1

chr7_+_30280094 1.306 ENSMUST00000108187.1
ENSMUST00000014072.5
Thap8

THAP domain containing 8

chr4_-_21685782 1.272 ENSMUST00000076206.4
Prdm13
PR domain containing 13
chr3_-_34351685 1.224 ENSMUST00000174114.1
Gm20514
predicted gene 20514
chr5_+_30105161 1.206 ENSMUST00000058045.4
Gareml
GRB2 associated, regulator of MAPK1-like
chr11_-_22982090 1.203 ENSMUST00000093270.5
ENSMUST00000071068.8
ENSMUST00000159081.1
ENSMUST00000160826.1
Commd1


RP23-242C19.7
COMM domain containing 1


UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 (B3gnt2), transcript variant 2, mRNA
chr18_-_35662180 1.195 ENSMUST00000025209.4
ENSMUST00000096573.2
Spata24

spermatogenesis associated 24

chr7_+_4925802 1.167 ENSMUST00000057612.7
Ssc5d
scavenger receptor cysteine rich domain containing (5 domains)
chr10_+_14523062 1.132 ENSMUST00000096020.5
Gm10335
predicted gene 10335
chr9_-_60522017 1.112 ENSMUST00000140824.1
Thsd4
thrombospondin, type I, domain containing 4
chr1_+_9545397 1.050 ENSMUST00000072079.7
Rrs1
RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
chr3_-_153912966 1.047 ENSMUST00000089950.4
Rabggtb
RAB geranylgeranyl transferase, b subunit
chr4_+_44981389 0.998 ENSMUST00000045078.6
ENSMUST00000128973.1
ENSMUST00000151148.1
Grhpr


glyoxylate reductase/hydroxypyruvate reductase


chr9_+_75775355 0.957 ENSMUST00000012281.7
Bmp5
bone morphogenetic protein 5
chr2_-_152398046 0.956 ENSMUST00000063332.8
ENSMUST00000182625.1
Sox12

SRY-box containing gene 12

chr2_-_25575224 0.955 ENSMUST00000039156.6
Phpt1
phosphohistidine phosphatase 1
chr12_-_71136611 0.933 ENSMUST00000021486.8
ENSMUST00000166120.1
Timm9

translocase of inner mitochondrial membrane 9

chr16_+_70313949 0.902 ENSMUST00000163832.1
Gbe1
glucan (1,4-alpha-), branching enzyme 1
chr15_-_10470490 0.858 ENSMUST00000136591.1
Dnajc21
DnaJ (Hsp40) homolog, subfamily C, member 21
chr17_+_34263209 0.833 ENSMUST00000040828.5
H2-Ab1
histocompatibility 2, class II antigen A, beta 1
chrX_+_42149534 0.832 ENSMUST00000127618.1
Stag2
stromal antigen 2
chr11_+_114668524 0.831 ENSMUST00000106602.3
ENSMUST00000077915.3
ENSMUST00000106599.1
ENSMUST00000082092.4
Rpl38



ribosomal protein L38



chr1_-_131097535 0.768 ENSMUST00000016672.4
Mapkapk2
MAP kinase-activated protein kinase 2
chr19_+_43752996 0.756 ENSMUST00000026199.7
ENSMUST00000112047.3
ENSMUST00000153295.1
Cutc


cutC copper transporter homolog (E.coli)


chr17_-_35897371 0.749 ENSMUST00000148721.1
2310061I04Rik
RIKEN cDNA 2310061I04 gene
chr15_-_79285502 0.729 ENSMUST00000165408.1
Baiap2l2
BAI1-associated protein 2-like 2
chrX_+_152001845 0.725 ENSMUST00000026289.3
ENSMUST00000112617.3
Hsd17b10

hydroxysteroid (17-beta) dehydrogenase 10

chr18_+_73859366 0.706 ENSMUST00000120033.1
ENSMUST00000179472.1
ENSMUST00000119239.1
Mro


maestro


chrX_+_7899350 0.697 ENSMUST00000033498.3
Timm17b
translocase of inner mitochondrial membrane 17b
chr2_-_129699833 0.639 ENSMUST00000028883.5
Pdyn
prodynorphin
chr10_+_63061582 0.581 ENSMUST00000020266.8
ENSMUST00000178684.1
Pbld1

phenazine biosynthesis-like protein domain containing 1

chr15_+_58933774 0.551 ENSMUST00000022980.3
Ndufb9
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9
chrX_+_13632769 0.549 ENSMUST00000096492.3
Gpr34
G protein-coupled receptor 34
chr11_+_108920342 0.525 ENSMUST00000052915.7
Axin2
axin2
chr17_-_83631892 0.524 ENSMUST00000051482.1
Kcng3
potassium voltage-gated channel, subfamily G, member 3
chr7_-_101921186 0.522 ENSMUST00000106965.1
ENSMUST00000106968.1
ENSMUST00000106967.1
Lrrc51


leucine rich repeat containing 51


chr10_+_82378593 0.512 ENSMUST00000165906.1
Gm4924
predicted gene 4924
chrX_+_42149288 0.497 ENSMUST00000115073.2
ENSMUST00000115072.1
Stag2

stromal antigen 2

chr13_+_72632597 0.467 ENSMUST00000172353.1
Irx2
Iroquois related homeobox 2 (Drosophila)
chr5_-_24445254 0.435 ENSMUST00000030800.6
Fastk
Fas-activated serine/threonine kinase
chrX_-_165004829 0.431 ENSMUST00000114890.2
Gm17604
predicted gene, 17604
chr4_-_41275091 0.431 ENSMUST00000030143.6
ENSMUST00000108068.1
Ubap2

ubiquitin-associated protein 2

chr13_-_92131494 0.407 ENSMUST00000099326.3
ENSMUST00000146492.1
Rasgrf2

RAS protein-specific guanine nucleotide-releasing factor 2

chr11_-_100759740 0.404 ENSMUST00000107361.2
Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chrX_-_49788204 0.402 ENSMUST00000114893.1
Igsf1
immunoglobulin superfamily, member 1
chr2_-_6130117 0.377 ENSMUST00000126551.1
ENSMUST00000054254.5
ENSMUST00000114942.2
Proser2


proline and serine rich 2


chr9_-_106887000 0.366 ENSMUST00000055843.7
Rbm15b
RNA binding motif protein 15B
chr1_+_63176818 0.333 ENSMUST00000129339.1
Eef1b2
eukaryotic translation elongation factor 1 beta 2
chrX_-_7899220 0.317 ENSMUST00000033497.2
Pqbp1
polyglutamine binding protein 1
chr11_-_109363654 0.316 ENSMUST00000070956.3
Gm11696
predicted gene 11696
chrX_+_135993820 0.314 ENSMUST00000058119.7
Arxes2
adipocyte-related X-chromosome expressed sequence 2
chr4_+_8690399 0.278 ENSMUST00000127476.1
Chd7
chromodomain helicase DNA binding protein 7
chrX_-_7899196 0.262 ENSMUST00000115654.1
Pqbp1
polyglutamine binding protein 1
chr14_+_53665912 0.235 ENSMUST00000181768.1
Trav3-3
T cell receptor alpha variable 3-3
chr11_+_113684412 0.233 ENSMUST00000042227.8
ENSMUST00000123466.1
ENSMUST00000106621.3
D11Wsu47e


DNA segment, Chr 11, Wayne State University 47, expressed


chr7_+_44848991 0.221 ENSMUST00000107885.1
Akt1s1
AKT1 substrate 1 (proline-rich)
chr3_-_37125943 0.216 ENSMUST00000029275.5
Il2
interleukin 2
chr13_-_107890059 0.214 ENSMUST00000105097.2
Zswim6
zinc finger SWIM-type containing 6
chr7_-_101921175 0.208 ENSMUST00000098236.2
Lrrc51
leucine rich repeat containing 51
chr7_-_126475082 0.199 ENSMUST00000032978.6
Sh2b1
SH2B adaptor protein 1
chr6_-_87851011 0.158 ENSMUST00000113617.1
Cnbp
cellular nucleic acid binding protein
chr9_-_56161051 0.155 ENSMUST00000034876.8
Tspan3
tetraspanin 3
chr19_-_43752924 0.151 ENSMUST00000045562.5
Cox15
cytochrome c oxidase assembly protein 15
chr14_-_46831984 0.121 ENSMUST00000181311.1
ENSMUST00000074862.2
Gm10101

predicted gene 10101

chr6_+_122707489 0.117 ENSMUST00000112581.1
ENSMUST00000112580.1
ENSMUST00000012540.4
Nanog


Nanog homeobox


chr15_-_98918131 0.113 ENSMUST00000023736.8
Lmbr1l
limb region 1 like
chr1_+_171329015 0.102 ENSMUST00000111300.1
Dedd
death effector domain-containing
chr2_+_80638798 0.051 ENSMUST00000028382.6
ENSMUST00000124377.1
Nup35

nucleoporin 35

chr2_-_165283599 0.051 ENSMUST00000155289.1
Slc35c2
solute carrier family 35, member C2
chr11_+_87699897 0.043 ENSMUST00000040089.4
Rnf43
ring finger protein 43
chr4_+_36952930 0.027 ENSMUST00000144029.1
Gm12371
predicted gene 12371
chr17_+_34644764 0.019 ENSMUST00000036720.8
Fkbpl
FK506 binding protein-like
chr2_+_181767040 0.015 ENSMUST00000108756.1
Myt1
myelin transcription factor 1
chr7_+_35186370 0.004 ENSMUST00000135452.1
ENSMUST00000001854.5
Slc7a10

solute carrier family 7 (cationic amino acid transporter, y+ system), member 10

chr1_+_74153981 0.000 ENSMUST00000027372.7
ENSMUST00000106899.2
Cxcr2

chemokine (C-X-C motif) receptor 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.4 10.1 GO:0021557 oculomotor nerve development(GO:0021557)
1.9 5.6 GO:0021759 globus pallidus development(GO:0021759)
1.5 4.5 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
1.3 8.8 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.7 2.2 GO:0036292 DNA rewinding(GO:0036292)
0.7 2.8 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.7 7.0 GO:0047484 regulation of response to osmotic stress(GO:0047484) cellular response to cholesterol(GO:0071397)
0.7 8.2 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.5 1.8 GO:0072272 proximal/distal pattern formation involved in metanephric nephron development(GO:0072272)
0.4 5.8 GO:0097154 GABAergic neuron differentiation(GO:0097154)
0.4 2.2 GO:1903215 negative regulation of protein targeting to mitochondrion(GO:1903215)
0.4 1.2 GO:1902071 regulation of hypoxia-inducible factor-1alpha signaling pathway(GO:1902071)
0.3 3.4 GO:2000653 regulation of genetic imprinting(GO:2000653)
0.3 6.2 GO:0032060 bleb assembly(GO:0032060)
0.2 3.9 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.2 2.2 GO:0009162 deoxyribonucleoside monophosphate metabolic process(GO:0009162)
0.2 1.0 GO:0021502 neural fold elevation formation(GO:0021502)
0.2 1.2 GO:2000483 response to bacterial lipoprotein(GO:0032493) negative regulation of interleukin-8 secretion(GO:2000483)
0.2 0.6 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
0.2 0.9 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.2 0.5 GO:0035590 purinergic nucleotide receptor signaling pathway(GO:0035590)
0.2 0.5 GO:0061181 regulation of chondrocyte development(GO:0061181)
0.2 0.8 GO:0002339 B cell selection(GO:0002339)
0.1 1.0 GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447)
0.1 1.3 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.1 1.0 GO:0018344 protein geranylgeranylation(GO:0018344)
0.1 1.1 GO:0048251 elastic fiber assembly(GO:0048251)
0.1 0.8 GO:0048318 axial mesoderm development(GO:0048318)
0.1 3.2 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.1 0.3 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.1 2.5 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.1 1.0 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.1 2.1 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.1 0.2 GO:0046013 T cell homeostatic proliferation(GO:0001777) regulation of T cell homeostatic proliferation(GO:0046013) negative regulation of T-helper 17 type immune response(GO:2000317) regulation of T-helper 17 cell differentiation(GO:2000319) negative regulation of T-helper 17 cell differentiation(GO:2000320)
0.0 2.8 GO:0042775 mitochondrial ATP synthesis coupled electron transport(GO:0042775)
0.0 0.8 GO:0055070 copper ion homeostasis(GO:0055070)
0.0 0.7 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.7 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0 0.1 GO:1903225 regulation of endodermal cell fate specification(GO:0042663) negative regulation of endodermal cell differentiation(GO:1903225)
0.0 5.1 GO:0048706 embryonic skeletal system development(GO:0048706)
0.0 2.1 GO:0016126 sterol biosynthetic process(GO:0016126)
0.0 1.0 GO:0007588 excretion(GO:0007588)
0.0 0.6 GO:0034063 stress granule assembly(GO:0034063) positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0 0.2 GO:0045792 negative regulation of cell size(GO:0045792)
0.0 0.1 GO:1901837 negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837)
0.0 1.5 GO:0035249 synaptic transmission, glutamatergic(GO:0035249)
0.0 0.6 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 0.9 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0 0.1 GO:0015786 UDP-glucose transport(GO:0015786)
0.0 1.0 GO:0021510 spinal cord development(GO:0021510)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 8.8 GO:0032133 interphase microtubule organizing center(GO:0031021) chromosome passenger complex(GO:0032133)
1.4 8.2 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.2 1.0 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.2 0.9 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.1 2.2 GO:0005652 nuclear lamina(GO:0005652)
0.1 0.8 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 1.3 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 1.2 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.1 0.7 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.1 1.1 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.1 9.0 GO:0016363 nuclear matrix(GO:0016363)
0.1 0.6 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.1 3.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 0.7 GO:0071439 clathrin complex(GO:0071439)
0.1 5.0 GO:0005844 polysome(GO:0005844)
0.1 7.0 GO:0005901 caveola(GO:0005901)
0.1 0.3 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 2.7 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 2.2 GO:0043596 nuclear replication fork(GO:0043596)
0.0 1.0 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 11.0 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.2 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.7 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.8 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 2.1 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 8.2 GO:0004526 ribonuclease P activity(GO:0004526)
0.7 2.8 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.6 3.3 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.5 5.6 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.4 3.9 GO:0042301 phosphate ion binding(GO:0042301)
0.4 10.1 GO:0008432 JUN kinase binding(GO:0008432)
0.3 2.1 GO:0070087 chromo shadow domain binding(GO:0070087)
0.3 1.0 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.2 0.9 GO:0003844 1,4-alpha-glucan branching enzyme activity(GO:0003844)
0.2 4.5 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.2 8.8 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.2 2.1 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.2 2.2 GO:0036310 annealing helicase activity(GO:0036310)
0.1 1.3 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 1.0 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.1 1.2 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.1 2.2 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.1 0.7 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.1 0.7 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.1 2.2 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds(GO:0016799)
0.1 1.0 GO:0070700 BMP receptor binding(GO:0070700)
0.1 0.9 GO:0031628 opioid receptor binding(GO:0031628)
0.1 3.2 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 1.0 GO:0008097 5S rRNA binding(GO:0008097)
0.1 0.5 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 0.8 GO:1990405 protein antigen binding(GO:1990405)
0.1 1.0 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.1 2.1 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 7.9 GO:0008565 protein transporter activity(GO:0008565)
0.1 0.8 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 1.2 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.4 GO:0034711 inhibin binding(GO:0034711)
0.0 1.5 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.5 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 1.5 GO:0019843 rRNA binding(GO:0019843)
0.0 0.4 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.1 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.0 1.3 GO:0042054 histone methyltransferase activity(GO:0042054)
0.0 1.0 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.8 GO:0005507 copper ion binding(GO:0005507)
0.0 0.3 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.3 GO:1990841 promoter-specific chromatin binding(GO:1990841)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 10.1 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 8.8 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 5.6 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 3.2 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 1.5 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.0 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.0 1.3 PID_PLK1_PATHWAY PLK1 signaling events
0.0 0.4 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.8 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.5 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.0 1.4 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.2 PID_IL23_PATHWAY IL23-mediated signaling events
0.0 0.3 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 9.8 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.1 4.6 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.1 10.2 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 2.1 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 4.5 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.1 1.5 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.1 4.5 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.8 REACTOME_DESTABILIZATION_OF_MRNA_BY_BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0 2.2 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 2.7 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 0.7 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 1.5 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.9 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.2 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.2 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 0.4 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.9 REACTOME_GLUCOSE_METABOLISM Genes involved in Glucose metabolism
0.0 0.8 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation