Motif ID: Tead3_Tead4

Z-value: 2.789

Transcription factors associated with Tead3_Tead4:

Gene SymbolEntrez IDGene Name
Tead3 ENSMUSG00000002249.11 Tead3
Tead4 ENSMUSG00000030353.9 Tead4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tead3mm10_v2_chr17_-_28350600_283506810.695.5e-07Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Tead3_Tead4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_24595623 37.880 ENSMUST00000176228.1
ENSMUST00000129142.1
Ctgf

connective tissue growth factor

chr14_-_54577578 35.159 ENSMUST00000054487.8
Ajuba
ajuba LIM protein
chr10_+_24595434 30.859 ENSMUST00000020171.5
Ctgf
connective tissue growth factor
chr12_-_80112998 29.455 ENSMUST00000165114.1
ENSMUST00000021552.1
Zfp36l1

zinc finger protein 36, C3H type-like 1

chr5_-_137314175 27.834 ENSMUST00000024119.9
Trip6
thyroid hormone receptor interactor 6
chr11_+_98412461 26.341 ENSMUST00000058295.5
Erbb2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
chr3_-_145649970 24.081 ENSMUST00000029846.3
Cyr61
cysteine rich protein 61
chr4_-_43558386 23.343 ENSMUST00000130353.1
Tln1
talin 1
chr10_-_78591945 23.258 ENSMUST00000040580.6
Syde1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr11_+_112782182 22.870 ENSMUST00000000579.2
Sox9
SRY-box containing gene 9
chr18_-_78206408 22.237 ENSMUST00000163367.1
Slc14a2
solute carrier family 14 (urea transporter), member 2
chr2_+_20519776 21.311 ENSMUST00000114604.2
ENSMUST00000066509.3
Etl4

enhancer trap locus 4

chr3_-_57575760 21.009 ENSMUST00000029380.7
Wwtr1
WW domain containing transcription regulator 1
chr15_+_6386598 16.180 ENSMUST00000080880.5
ENSMUST00000110664.2
ENSMUST00000110663.2
ENSMUST00000161812.1
ENSMUST00000160134.1
Dab2




disabled 2, mitogen-responsive phosphoprotein




chr9_+_69454066 15.442 ENSMUST00000134907.1
Anxa2
annexin A2
chr17_+_78508063 14.866 ENSMUST00000024880.9
Vit
vitrin
chr1_-_72874877 14.194 ENSMUST00000027377.8
Igfbp5
insulin-like growth factor binding protein 5
chr6_+_17306335 14.162 ENSMUST00000007799.6
ENSMUST00000115456.1
ENSMUST00000115455.2
ENSMUST00000130505.1
Cav1



caveolin 1, caveolae protein



chr13_-_113046357 14.037 ENSMUST00000022282.3
Gpx8
glutathione peroxidase 8 (putative)
chr3_-_57575907 13.102 ENSMUST00000120977.1
Wwtr1
WW domain containing transcription regulator 1
chr18_+_60911757 12.698 ENSMUST00000040359.5
Arsi
arylsulfatase i
chr8_-_94918012 12.290 ENSMUST00000077955.5
Ccdc102a
coiled-coil domain containing 102A
chr7_-_109616548 11.652 ENSMUST00000077909.1
ENSMUST00000084738.3
St5

suppression of tumorigenicity 5

chr2_+_91457501 11.349 ENSMUST00000028689.3
Lrp4
low density lipoprotein receptor-related protein 4
chr10_+_4710119 10.687 ENSMUST00000105588.1
ENSMUST00000105589.1
Esr1

estrogen receptor 1 (alpha)

chr9_+_69453620 10.309 ENSMUST00000034756.8
ENSMUST00000123470.1
Anxa2

annexin A2

chr8_-_61760067 10.162 ENSMUST00000121493.1
Palld
palladin, cytoskeletal associated protein
chr14_+_46882854 10.137 ENSMUST00000022386.8
ENSMUST00000100672.3
Samd4

sterile alpha motif domain containing 4

chr15_-_103366763 9.257 ENSMUST00000023128.6
Itga5
integrin alpha 5 (fibronectin receptor alpha)
chr9_+_35421541 8.517 ENSMUST00000119129.2
Cdon
cell adhesion molecule-related/down-regulated by oncogenes
chr11_-_115813621 8.495 ENSMUST00000041684.4
ENSMUST00000156812.1
Caskin2

CASK-interacting protein 2

chr1_+_43730593 8.344 ENSMUST00000027217.8
1500015O10Rik
RIKEN cDNA 1500015O10 gene
chr10_+_93641041 8.325 ENSMUST00000020204.4
Ntn4
netrin 4
chr3_-_101110278 8.229 ENSMUST00000102694.3
Ptgfrn
prostaglandin F2 receptor negative regulator
chr11_-_5381734 7.865 ENSMUST00000172492.1
Znrf3
zinc and ring finger 3
chr11_+_70700473 7.448 ENSMUST00000152618.2
ENSMUST00000102554.1
ENSMUST00000094499.4
ENSMUST00000072187.5
Kif1c



kinesin family member 1C



chr2_-_26092149 7.115 ENSMUST00000114159.2
Nacc2
nucleus accumbens associated 2, BEN and BTB (POZ) domain containing
chr5_+_63812447 7.059 ENSMUST00000081747.3
0610040J01Rik
RIKEN cDNA 0610040J01 gene
chr7_+_128523576 6.881 ENSMUST00000033136.7
Bag3
BCL2-associated athanogene 3
chr1_-_120120138 6.859 ENSMUST00000112648.1
ENSMUST00000128408.1
Dbi

diazepam binding inhibitor

chr6_+_17307040 6.587 ENSMUST00000123439.1
Cav1
caveolin 1, caveolae protein
chr18_+_50030977 6.580 ENSMUST00000145726.1
ENSMUST00000128377.1
Tnfaip8

tumor necrosis factor, alpha-induced protein 8

chr18_-_60501983 6.450 ENSMUST00000042710.6
Smim3
small integral membrane protein 3
chr17_+_88626569 6.300 ENSMUST00000150023.1
Ston1
stonin 1
chr10_-_13324250 6.221 ENSMUST00000105543.1
Phactr2
phosphatase and actin regulator 2
chr19_-_4439388 6.172 ENSMUST00000117462.1
ENSMUST00000048197.3
Rhod

ras homolog gene family, member D

chr10_+_126978690 6.169 ENSMUST00000105256.2
Ctdsp2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
chr15_+_78842632 6.122 ENSMUST00000059619.1
Cdc42ep1
CDC42 effector protein (Rho GTPase binding) 1
chr11_+_70700606 5.968 ENSMUST00000137119.2
Kif1c
kinesin family member 1C
chr8_-_47990535 5.923 ENSMUST00000057561.7
Wwc2
WW, C2 and coiled-coil domain containing 2
chr1_+_74391479 5.762 ENSMUST00000027367.7
Ctdsp1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr2_-_156839790 5.724 ENSMUST00000134838.1
ENSMUST00000137463.1
ENSMUST00000149275.2
Gm14230


predicted gene 14230


chr11_-_32222233 5.642 ENSMUST00000150381.1
ENSMUST00000144902.1
ENSMUST00000020524.8
Rhbdf1


rhomboid family 1 (Drosophila)


chr17_+_47593444 5.637 ENSMUST00000182209.1
Ccnd3
cyclin D3
chr15_+_25773985 5.627 ENSMUST00000125667.1
Myo10
myosin X
chr10_-_128704978 5.608 ENSMUST00000026416.7
ENSMUST00000026415.7
Cdk2

cyclin-dependent kinase 2

chr17_+_88626549 5.416 ENSMUST00000163588.1
ENSMUST00000064035.6
Ston1

stonin 1

chr13_-_81570640 5.395 ENSMUST00000109565.2
Gpr98
G protein-coupled receptor 98
chr5_+_77265454 5.388 ENSMUST00000080359.5
Rest
RE1-silencing transcription factor
chr7_-_38107490 5.386 ENSMUST00000108023.3
Ccne1
cyclin E1
chr5_+_77266196 5.349 ENSMUST00000113449.1
Rest
RE1-silencing transcription factor
chr10_-_58675631 5.325 ENSMUST00000003312.4
Edar
ectodysplasin-A receptor
chr4_+_98546710 5.272 ENSMUST00000102792.3
Inadl
InaD-like (Drosophila)
chr6_-_138426735 5.271 ENSMUST00000162932.1
Lmo3
LIM domain only 3
chr6_+_17306415 5.194 ENSMUST00000150901.1
Cav1
caveolin 1, caveolae protein
chr17_+_47593516 5.117 ENSMUST00000182874.1
Ccnd3
cyclin D3
chr4_+_98546919 5.088 ENSMUST00000030290.7
Inadl
InaD-like (Drosophila)
chr14_-_69284982 5.077 ENSMUST00000183882.1
ENSMUST00000037064.4
Slc25a37

solute carrier family 25, member 37

chr6_+_29433248 5.069 ENSMUST00000101617.2
ENSMUST00000065090.5
Flnc

filamin C, gamma

chr15_-_37458523 4.807 ENSMUST00000116445.2
Ncald
neurocalcin delta
chr5_+_66968416 4.712 ENSMUST00000038188.7
Limch1
LIM and calponin homology domains 1
chr18_+_50053282 4.668 ENSMUST00000148159.2
Tnfaip8
tumor necrosis factor, alpha-induced protein 8
chr4_-_154636831 4.485 ENSMUST00000030902.6
ENSMUST00000105637.1
ENSMUST00000070313.7
ENSMUST00000105636.1
ENSMUST00000105638.2
ENSMUST00000097759.2
ENSMUST00000124771.1
Prdm16






PR domain containing 16






chr11_+_100415697 4.469 ENSMUST00000001595.3
Fkbp10
FK506 binding protein 10
chr7_-_115824699 4.425 ENSMUST00000169129.1
Sox6
SRY-box containing gene 6
chr2_+_19658055 4.416 ENSMUST00000052168.4
Otud1
OTU domain containing 1
chr12_-_98737405 4.250 ENSMUST00000170188.1
Ptpn21
protein tyrosine phosphatase, non-receptor type 21
chr6_-_23839137 4.140 ENSMUST00000166458.2
ENSMUST00000142913.2
ENSMUST00000115357.1
ENSMUST00000069074.7
ENSMUST00000115361.2
ENSMUST00000018122.7
ENSMUST00000115355.1
ENSMUST00000115356.2
Cadps2







Ca2+-dependent activator protein for secretion 2







chr9_-_96437434 4.109 ENSMUST00000070500.2
BC043934
cDNA sequence BC043934
chr7_-_34133215 4.102 ENSMUST00000038537.8
Wtip
WT1-interacting protein
chrX_+_10717451 4.094 ENSMUST00000156321.1
Mid1ip1
Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish))
chr2_+_52038005 3.981 ENSMUST00000065927.5
Tnfaip6
tumor necrosis factor alpha induced protein 6
chr19_-_42129043 3.973 ENSMUST00000018965.3
Avpi1
arginine vasopressin-induced 1
chrX_+_10717390 3.875 ENSMUST00000115524.1
ENSMUST00000008179.6
Mid1ip1

Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish))

chr6_+_29433131 3.858 ENSMUST00000090474.4
Flnc
filamin C, gamma
chr6_+_29694204 3.763 ENSMUST00000046750.7
ENSMUST00000115250.3
Tspan33

tetraspanin 33

chr6_+_29735667 3.748 ENSMUST00000001812.4
Smo
smoothened homolog (Drosophila)
chr13_-_74807913 3.736 ENSMUST00000065629.4
Cast
calpastatin
chr17_-_28350747 3.704 ENSMUST00000080572.7
ENSMUST00000156862.1
Tead3

TEA domain family member 3

chr8_+_57511833 3.702 ENSMUST00000067925.6
Hmgb2
high mobility group box 2
chr5_+_66968559 3.700 ENSMUST00000127184.1
Limch1
LIM and calponin homology domains 1
chr12_+_75308308 3.695 ENSMUST00000118602.1
ENSMUST00000118966.1
ENSMUST00000055390.5
Rhoj


ras homolog gene family, member J


chr7_-_19698206 3.679 ENSMUST00000172808.1
ENSMUST00000174191.1
Apoe

apolipoprotein E

chr16_-_46155077 3.625 ENSMUST00000059524.5
Gm4737
predicted gene 4737
chr19_-_12765447 3.599 ENSMUST00000112933.1
Cntf
ciliary neurotrophic factor
chr11_+_100415722 3.576 ENSMUST00000107400.2
Fkbp10
FK506 binding protein 10
chr17_+_3397189 3.572 ENSMUST00000072156.6
Tiam2
T cell lymphoma invasion and metastasis 2
chr6_-_99520949 3.550 ENSMUST00000176565.1
Foxp1
forkhead box P1
chr13_-_3893556 3.542 ENSMUST00000099946.4
Net1
neuroepithelial cell transforming gene 1
chrX_+_96456362 3.503 ENSMUST00000079322.5
ENSMUST00000113838.1
Heph

hephaestin

chr19_+_8989277 3.493 ENSMUST00000092955.3
ENSMUST00000092956.2
Ahnak

AHNAK nucleoprotein (desmoyokin)

chr5_+_24426831 3.457 ENSMUST00000155598.1
Slc4a2
solute carrier family 4 (anion exchanger), member 2
chr4_+_133176336 3.447 ENSMUST00000105912.1
Wasf2
WAS protein family, member 2
chr7_-_65370908 3.425 ENSMUST00000032729.6
Tjp1
tight junction protein 1
chr19_+_46305682 3.410 ENSMUST00000111881.2
Nfkb2
nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
chr8_+_14911663 3.394 ENSMUST00000084207.5
ENSMUST00000161162.1
ENSMUST00000110800.2
Arhgef10


Rho guanine nucleotide exchange factor (GEF) 10


chrX_+_139217166 3.354 ENSMUST00000166444.1
ENSMUST00000170671.1
ENSMUST00000113041.2
ENSMUST00000113042.2
Mum1l1



melanoma associated antigen (mutated) 1-like 1



chr17_-_28350600 3.330 ENSMUST00000114799.1
Tead3
TEA domain family member 3
chr17_-_71002488 3.267 ENSMUST00000148960.1
Myl12a
myosin, light chain 12A, regulatory, non-sarcomeric
chr11_-_115808068 2.985 ENSMUST00000132780.1
Caskin2
CASK-interacting protein 2
chr6_+_82041623 2.975 ENSMUST00000042974.8
Eva1a
eva-1 homolog A (C. elegans)
chr7_-_90129339 2.943 ENSMUST00000181189.1
2310010J17Rik
RIKEN cDNA 2310010J17 gene
chr14_-_69503220 2.926 ENSMUST00000180059.2
Gm21464
predicted gene, 21464
chr9_-_95815389 2.859 ENSMUST00000119760.1
Pls1
plastin 1 (I-isoform)
chrX_-_142306170 2.809 ENSMUST00000134825.2
Kcne1l
potassium voltage-gated channel, Isk-related family, member 1-like, pseudogene
chr3_-_135691512 2.797 ENSMUST00000029812.7
Nfkb1
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
chr2_-_73485733 2.784 ENSMUST00000102680.1
Wipf1
WAS/WASL interacting protein family, member 1
chr4_+_141301228 2.774 ENSMUST00000006614.2
Epha2
Eph receptor A2
chr4_+_102254739 2.743 ENSMUST00000106907.2
Pde4b
phosphodiesterase 4B, cAMP specific
chr2_+_156840077 2.739 ENSMUST00000081335.6
ENSMUST00000073352.3
Tgif2

TGFB-induced factor homeobox 2

chr19_-_42128982 2.724 ENSMUST00000161873.1
Avpi1
arginine vasopressin-induced 1
chr1_+_12692430 2.632 ENSMUST00000180062.1
ENSMUST00000177608.1
Sulf1

sulfatase 1

chr3_-_103737995 2.617 ENSMUST00000029440.8
Olfml3
olfactomedin-like 3
chr3_-_142169196 2.615 ENSMUST00000098568.1
Bmpr1b
bone morphogenetic protein receptor, type 1B
chr19_-_57197556 2.608 ENSMUST00000099294.2
Ablim1
actin-binding LIM protein 1
chr14_-_48662740 2.570 ENSMUST00000122009.1
Otx2
orthodenticle homolog 2 (Drosophila)
chr9_-_67539392 2.535 ENSMUST00000039662.8
Tln2
talin 2
chr17_-_15375969 2.527 ENSMUST00000014917.7
Dll1
delta-like 1 (Drosophila)
chr1_-_136234113 2.511 ENSMUST00000120339.1
ENSMUST00000048668.8
5730559C18Rik

RIKEN cDNA 5730559C18 gene

chr3_-_116424007 2.426 ENSMUST00000090464.4
Cdc14a
CDC14 cell division cycle 14A
chr3_-_116423930 2.420 ENSMUST00000106491.2
Cdc14a
CDC14 cell division cycle 14A
chr16_-_36784924 2.403 ENSMUST00000168279.1
ENSMUST00000164579.1
ENSMUST00000023616.2
Slc15a2


solute carrier family 15 (H+/peptide transporter), member 2


chr1_+_104768510 2.400 ENSMUST00000062528.8
Cdh20
cadherin 20
chrX_+_82948861 2.343 ENSMUST00000114000.1
Dmd
dystrophin, muscular dystrophy
chr6_+_83034173 2.336 ENSMUST00000000707.2
ENSMUST00000101257.3
Loxl3

lysyl oxidase-like 3

chr1_+_169928648 2.274 ENSMUST00000094348.3
1700084C01Rik
RIKEN cDNA 1700084C01 gene
chr15_-_33405976 2.227 ENSMUST00000079057.6
1700084J12Rik
RIKEN cDNA 1700084J12 gene
chrX_-_74246364 2.226 ENSMUST00000130007.1
Flna
filamin, alpha
chr8_-_105966038 2.203 ENSMUST00000116429.2
ENSMUST00000034370.9
Slc12a4

solute carrier family 12, member 4

chr13_-_83729544 2.195 ENSMUST00000181705.1
Gm26803
predicted gene, 26803
chr4_+_89137122 2.177 ENSMUST00000058030.7
Mtap
methylthioadenosine phosphorylase
chr6_+_48593927 2.167 ENSMUST00000135151.1
Repin1
replication initiator 1
chrX_+_101254528 2.138 ENSMUST00000062000.4
Foxo4
forkhead box O4
chr4_+_118429701 2.092 ENSMUST00000067896.3
Elovl1
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1
chr3_+_37639945 2.066 ENSMUST00000108109.1
ENSMUST00000038569.1
Spry1

sprouty homolog 1 (Drosophila)

chr3_+_54156039 2.064 ENSMUST00000029311.6
Trpc4
transient receptor potential cation channel, subfamily C, member 4
chr17_-_71002017 2.053 ENSMUST00000128179.1
ENSMUST00000150456.1
Myl12a

myosin, light chain 12A, regulatory, non-sarcomeric

chr9_-_35176039 1.997 ENSMUST00000119847.1
ENSMUST00000034539.5
Dcps

decapping enzyme, scavenger

chr16_+_20674111 1.966 ENSMUST00000151679.1
Eif4g1
eukaryotic translation initiation factor 4, gamma 1
chr19_+_45018114 1.965 ENSMUST00000178087.1
Lzts2
leucine zipper, putative tumor suppressor 2
chr10_-_89443888 1.960 ENSMUST00000099374.2
ENSMUST00000105298.1
Gas2l3

growth arrest-specific 2 like 3

chr7_-_19698383 1.894 ENSMUST00000173739.1
Apoe
apolipoprotein E
chr1_+_42229726 1.885 ENSMUST00000066196.1
Gm9915
predicted gene 9915
chr5_+_136991624 1.848 ENSMUST00000127100.1
Plod3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr10_-_128176568 1.817 ENSMUST00000092033.2
Rbms2
RNA binding motif, single stranded interacting protein 2
chr3_+_37639985 1.808 ENSMUST00000108107.1
Spry1
sprouty homolog 1 (Drosophila)
chrX_-_74246534 1.760 ENSMUST00000101454.2
ENSMUST00000033699.6
Flna

filamin, alpha

chr19_-_57197496 1.752 ENSMUST00000111544.1
Ablim1
actin-binding LIM protein 1
chr11_-_69880971 1.730 ENSMUST00000050555.3
Kctd11
potassium channel tetramerisation domain containing 11
chr13_+_112464070 1.701 ENSMUST00000183663.1
ENSMUST00000184311.1
ENSMUST00000183886.1
Il6st


interleukin 6 signal transducer


chr17_-_47834682 1.693 ENSMUST00000066368.6
Mdfi
MyoD family inhibitor
chr13_+_119606650 1.683 ENSMUST00000178948.1
Gm21967
predicted gene, 21967
chr1_+_165769392 1.676 ENSMUST00000040298.4
Creg1
cellular repressor of E1A-stimulated genes 1
chr14_-_57746044 1.673 ENSMUST00000173990.1
ENSMUST00000022531.7
Lats2

large tumor suppressor 2

chr2_+_72285637 1.672 ENSMUST00000090824.5
ENSMUST00000135469.1
Zak

sterile alpha motif and leucine zipper containing kinase AZK

chr4_+_107879745 1.653 ENSMUST00000030348.5
Magoh
mago-nashi homolog, proliferation-associated (Drosophila)
chr14_+_30879257 1.616 ENSMUST00000040715.6
Mustn1
musculoskeletal, embryonic nuclear protein 1
chr15_-_36598019 1.591 ENSMUST00000155116.1
Pabpc1
poly(A) binding protein, cytoplasmic 1
chr12_-_55014329 1.589 ENSMUST00000172875.1
Baz1a
bromodomain adjacent to zinc finger domain 1A
chr12_-_73113407 1.581 ENSMUST00000175693.1
Six4
sine oculis-related homeobox 4
chr4_-_4138432 1.581 ENSMUST00000070375.7
Penk
preproenkephalin
chr11_+_72441341 1.580 ENSMUST00000045633.5
Mybbp1a
MYB binding protein (P160) 1a
chr17_-_57000018 1.567 ENSMUST00000002740.2
Pspn
persephin
chr3_-_152266320 1.564 ENSMUST00000046045.8
Nexn
nexilin
chr2_+_31572651 1.545 ENSMUST00000113482.1
Fubp3
far upstream element (FUSE) binding protein 3
chr13_-_102906046 1.533 ENSMUST00000171791.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr14_-_48667508 1.479 ENSMUST00000144465.1
ENSMUST00000133479.1
ENSMUST00000119070.1
ENSMUST00000152018.1
Otx2



orthodenticle homolog 2 (Drosophila)



chr2_+_32775769 1.464 ENSMUST00000066352.5
Ptrh1
peptidyl-tRNA hydrolase 1 homolog (S. cerevisiae)
chr2_-_73486456 1.421 ENSMUST00000141264.1
Wipf1
WAS/WASL interacting protein family, member 1
chr10_+_80805233 1.403 ENSMUST00000036016.4
Amh
anti-Mullerian hormone
chr7_-_132813799 1.383 ENSMUST00000097998.2
Fam53b
family with sequence similarity 53, member B
chr10_+_128790903 1.375 ENSMUST00000026411.6
Mmp19
matrix metallopeptidase 19
chr6_+_135065651 1.366 ENSMUST00000050104.7
Gprc5a
G protein-coupled receptor, family C, group 5, member A
chr5_+_76951382 1.356 ENSMUST00000141687.1
Paics
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase
chr9_-_79718631 1.343 ENSMUST00000180083.1
Col12a1
collagen, type XII, alpha 1
chr2_+_121295437 1.343 ENSMUST00000110639.1
Map1a
microtubule-associated protein 1 A
chr19_-_23448322 1.332 ENSMUST00000036069.6
Mamdc2
MAM domain containing 2
chr13_-_102905740 1.330 ENSMUST00000167462.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr2_-_92370999 1.316 ENSMUST00000176810.1
ENSMUST00000090582.4
Gyltl1b

glycosyltransferase-like 1B

chr2_-_149798701 1.302 ENSMUST00000148202.1
ENSMUST00000139471.1
Gm14133

predicted gene 14133

chr10_-_127288999 1.297 ENSMUST00000119078.1
Mbd6
methyl-CpG binding domain protein 6
chr19_-_57197435 1.286 ENSMUST00000111550.1
Ablim1
actin-binding LIM protein 1
chr4_-_97778042 1.286 ENSMUST00000146447.1
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr17_-_35697971 1.264 ENSMUST00000146472.1
Ddr1
discoidin domain receptor family, member 1
chr9_+_44101722 1.254 ENSMUST00000161703.1
ENSMUST00000161381.1
ENSMUST00000034654.7
Mfrp


membrane-type frizzled-related protein


chr19_-_57197377 1.253 ENSMUST00000111546.1
Ablim1
actin-binding LIM protein 1
chr15_+_81744848 1.219 ENSMUST00000109554.1
Zc3h7b
zinc finger CCCH type containing 7B
chr4_-_132398199 1.194 ENSMUST00000136711.1
ENSMUST00000084249.4
Phactr4

phosphatase and actin regulator 4

chr18_-_35722330 1.192 ENSMUST00000133064.1
Ecscr
endothelial cell surface expressed chemotaxis and apoptosis regulator
chr6_-_90716489 1.173 ENSMUST00000101153.3
Iqsec1
IQ motif and Sec7 domain 1

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
17.2 68.7 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
11.4 22.9 GO:0072190 ureter urothelium development(GO:0072190) ureter morphogenesis(GO:0072197)
9.8 29.5 GO:1904580 regulation of intracellular mRNA localization(GO:1904580)
8.8 26.3 GO:0033088 negative regulation of immature T cell proliferation in thymus(GO:0033088)
7.4 22.2 GO:0071918 urea transmembrane transport(GO:0071918)
6.5 45.2 GO:0035331 negative regulation of hippo signaling(GO:0035331)
6.0 24.1 GO:0003278 apoptotic process involved in heart morphogenesis(GO:0003278)
5.2 25.9 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
5.2 25.8 GO:0052428 modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
4.9 34.1 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
4.7 23.3 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
4.6 27.8 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
3.8 11.3 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
3.6 10.7 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
3.2 16.2 GO:0032346 positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349)
3.2 25.9 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
2.7 10.7 GO:2000705 regulation of dense core granule biogenesis(GO:2000705)
2.1 8.3 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
2.1 14.4 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
1.9 5.6 GO:1903002 regulation of lipid transport across blood brain barrier(GO:1903000) positive regulation of lipid transport across blood brain barrier(GO:1903002)
1.7 8.4 GO:0038018 Wnt receptor catabolic process(GO:0038018)
1.4 6.9 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
1.3 4.0 GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
1.3 2.5 GO:0045168 cell-cell signaling involved in cell fate commitment(GO:0045168)
1.3 10.1 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
1.2 3.6 GO:0048687 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
1.1 5.6 GO:0032298 positive regulation of DNA-dependent DNA replication initiation(GO:0032298)
1.0 8.3 GO:0070314 G1 to G0 transition(GO:0070314)
1.0 4.0 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
1.0 2.9 GO:0001951 intestinal D-glucose absorption(GO:0001951) terminal web assembly(GO:1902896)
0.9 3.7 GO:0007228 positive regulation of hh target transcription factor activity(GO:0007228) pancreas morphogenesis(GO:0061113) metanephric renal vesicle formation(GO:0072093)
0.9 2.8 GO:0070309 notochord formation(GO:0014028) lens fiber cell morphogenesis(GO:0070309) negative regulation of lymphangiogenesis(GO:1901491)
0.9 4.4 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.8 2.3 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.8 3.9 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.7 2.8 GO:0060372 regulation of atrial cardiac muscle cell membrane repolarization(GO:0060372)
0.7 2.8 GO:1903416 negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137) regulation of calcidiol 1-monooxygenase activity(GO:0060558) response to glycoside(GO:1903416)
0.7 5.3 GO:0060662 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.7 6.6 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.7 2.6 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.7 2.6 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.6 1.9 GO:1902396 protein localization to bicellular tight junction(GO:1902396)
0.6 7.4 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.6 4.1 GO:1990504 dense core granule exocytosis(GO:1990504)
0.6 2.3 GO:2000319 negative regulation of T-helper 17 type immune response(GO:2000317) regulation of T-helper 17 cell differentiation(GO:2000319) negative regulation of T-helper 17 cell differentiation(GO:2000320)
0.6 1.7 GO:0038165 oncostatin-M-mediated signaling pathway(GO:0038165) regulation of interleukin-6-mediated signaling pathway(GO:0070103) negative regulation of interleukin-6-mediated signaling pathway(GO:0070104)
0.6 10.2 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.6 4.5 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.6 1.7 GO:0001827 inner cell mass cell fate commitment(GO:0001827)
0.5 7.1 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.5 2.2 GO:0006166 purine ribonucleoside salvage(GO:0006166)
0.5 3.7 GO:0007343 egg activation(GO:0007343)
0.5 8.0 GO:0045723 positive regulation of fatty acid biosynthetic process(GO:0045723)
0.5 3.7 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.5 7.0 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.5 2.0 GO:0042360 vitamin E metabolic process(GO:0042360)
0.5 4.8 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.5 2.4 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.5 2.4 GO:0042891 antibiotic transport(GO:0042891) dipeptide transport(GO:0042938)
0.5 1.4 GO:0048162 preantral ovarian follicle growth(GO:0001546) multi-layer follicle stage(GO:0048162)
0.5 1.8 GO:0046947 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.5 8.2 GO:0034389 lipid particle organization(GO:0034389)
0.5 11.7 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.4 1.6 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.4 1.5 GO:1900220 semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220)
0.4 6.9 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.4 3.7 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.4 1.1 GO:0016095 polyprenol catabolic process(GO:0016095)
0.4 5.8 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.4 2.5 GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway(GO:0070423) nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070431)
0.4 3.6 GO:0061470 interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619)
0.3 1.7 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406)
0.3 2.0 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.3 1.6 GO:1902732 positive regulation of chondrocyte proliferation(GO:1902732)
0.3 1.6 GO:2000987 positive regulation of fear response(GO:1903367) positive regulation of behavioral fear response(GO:2000987)
0.3 2.1 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.3 1.2 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.3 8.0 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.3 3.4 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.3 3.4 GO:0002467 germinal center formation(GO:0002467)
0.3 0.8 GO:0003219 cardiac right ventricle formation(GO:0003219)
0.3 3.5 GO:0051451 myoblast migration(GO:0051451)
0.3 12.2 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.3 1.3 GO:1905169 protein localization to phagocytic vesicle(GO:1905161) regulation of protein localization to phagocytic vesicle(GO:1905169) positive regulation of protein localization to phagocytic vesicle(GO:1905171)
0.3 1.6 GO:2000210 positive regulation of anoikis(GO:2000210)
0.3 2.1 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.2 0.9 GO:0002667 lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911)
0.2 0.9 GO:0033580 protein glycosylation at cell surface(GO:0033575) protein galactosylation at cell surface(GO:0033580) protein galactosylation(GO:0042125)
0.2 11.9 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.2 2.7 GO:0038092 nodal signaling pathway(GO:0038092)
0.2 0.7 GO:1904207 chemokine (C-C motif) ligand 2 secretion(GO:0035926) regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.2 1.3 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.2 11.2 GO:0032611 interleukin-1 beta production(GO:0032611)
0.2 8.6 GO:0006826 iron ion transport(GO:0006826)
0.2 6.4 GO:2000249 regulation of actin cytoskeleton reorganization(GO:2000249)
0.2 3.4 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592)
0.2 1.1 GO:0070094 positive regulation of glucagon secretion(GO:0070094)
0.2 23.0 GO:0048706 embryonic skeletal system development(GO:0048706)
0.2 0.8 GO:0044828 negative regulation by host of viral process(GO:0044793) negative regulation by host of viral genome replication(GO:0044828)
0.2 2.7 GO:1901841 regulation of high voltage-gated calcium channel activity(GO:1901841)
0.2 0.5 GO:2000850 cortisol secretion(GO:0043400) regulation of cortisol secretion(GO:0051462) negative regulation of corticosteroid hormone secretion(GO:2000847) negative regulation of glucocorticoid secretion(GO:2000850)
0.2 1.0 GO:0097264 self proteolysis(GO:0097264)
0.2 5.4 GO:0006270 DNA replication initiation(GO:0006270)
0.2 14.7 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.1 1.3 GO:0018095 protein polyglutamylation(GO:0018095)
0.1 1.0 GO:0031642 negative regulation of myelination(GO:0031642)
0.1 0.7 GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195) histone H4-R3 methylation(GO:0043985)
0.1 1.1 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.1 6.8 GO:0048747 muscle fiber development(GO:0048747)
0.1 7.0 GO:0042058 regulation of epidermal growth factor receptor signaling pathway(GO:0042058)
0.1 0.5 GO:0032836 glomerular basement membrane development(GO:0032836)
0.1 0.7 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.1 5.3 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.1 0.7 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.1 2.2 GO:2001273 regulation of glucose import in response to insulin stimulus(GO:2001273)
0.1 1.4 GO:0030574 collagen catabolic process(GO:0030574)
0.1 2.0 GO:0010801 negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
0.1 0.4 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.1 4.7 GO:0030032 lamellipodium assembly(GO:0030032)
0.1 1.0 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.1 0.5 GO:1903275 positive regulation of sodium ion export(GO:1903275) positive regulation of sodium ion export from cell(GO:1903278)
0.1 1.0 GO:0045199 maintenance of epithelial cell apical/basal polarity(GO:0045199)
0.1 1.1 GO:0048642 negative regulation of skeletal muscle tissue development(GO:0048642)
0.1 2.0 GO:1900181 negative regulation of protein localization to nucleus(GO:1900181)
0.1 1.1 GO:0003215 cardiac right ventricle morphogenesis(GO:0003215)
0.1 2.6 GO:0051496 positive regulation of stress fiber assembly(GO:0051496)
0.1 1.0 GO:1904293 negative regulation of ERAD pathway(GO:1904293)
0.1 4.0 GO:0050728 negative regulation of inflammatory response(GO:0050728)
0.1 2.2 GO:0006813 potassium ion transport(GO:0006813)
0.1 4.5 GO:0000187 activation of MAPK activity(GO:0000187)
0.1 1.4 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 0.4 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.3 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 1.0 GO:0035411 catenin import into nucleus(GO:0035411)
0.0 1.3 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.0 2.2 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.0 2.8 GO:0051453 regulation of intracellular pH(GO:0051453)
0.0 0.9 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 0.7 GO:0010107 potassium ion import(GO:0010107)
0.0 2.4 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 2.1 GO:0048709 oligodendrocyte differentiation(GO:0048709)
0.0 0.3 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)
0.0 0.1 GO:0046487 glyoxylate metabolic process(GO:0046487)
0.0 0.3 GO:0060441 epithelial tube branching involved in lung morphogenesis(GO:0060441)
0.0 0.1 GO:0035562 negative regulation of chromatin binding(GO:0035562)
0.0 0.1 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.0 1.6 GO:0006261 DNA-dependent DNA replication(GO:0006261)
0.0 0.2 GO:0035767 endothelial cell chemotaxis(GO:0035767)
0.0 0.9 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.0 1.7 GO:0051028 mRNA transport(GO:0051028)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
8.6 25.8 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
4.0 16.2 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
3.5 14.2 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
2.0 26.3 GO:0043219 lateral loop(GO:0043219)
1.9 5.6 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
1.9 5.6 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
1.9 24.1 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
1.5 10.7 GO:0097550 transcriptional preinitiation complex(GO:0097550)
1.2 64.1 GO:0005801 cis-Golgi network(GO:0005801)
1.2 3.6 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
1.2 16.2 GO:0005614 interstitial matrix(GO:0005614)
1.1 3.4 GO:0030934 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)
1.1 23.3 GO:0044300 cerebellar mossy fiber(GO:0044300)
1.0 11.3 GO:0016600 flotillin complex(GO:0016600)
0.9 6.2 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.8 4.0 GO:0031523 Myb complex(GO:0031523)
0.7 74.9 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.6 1.1 GO:0005899 insulin receptor complex(GO:0005899)
0.6 2.9 GO:1990357 terminal web(GO:1990357)
0.6 1.7 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.5 1.6 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.4 3.4 GO:0046581 intercellular canaliculus(GO:0046581)
0.4 3.7 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.4 9.3 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.4 1.6 GO:0008623 CHRAC(GO:0008623)
0.4 1.6 GO:0032280 symmetric synapse(GO:0032280)
0.3 22.0 GO:0016459 myosin complex(GO:0016459)
0.3 3.7 GO:0044294 dendritic growth cone(GO:0044294)
0.3 7.1 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.3 4.4 GO:0031045 dense core granule(GO:0031045)
0.3 3.4 GO:0031209 SCAR complex(GO:0031209)
0.3 2.5 GO:0005916 fascia adherens(GO:0005916)
0.3 2.0 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.3 15.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 10.2 GO:0002102 podosome(GO:0002102)
0.2 13.4 GO:0005871 kinesin complex(GO:0005871)
0.2 4.8 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.2 79.8 GO:0030055 cell-substrate junction(GO:0030055)
0.2 14.6 GO:0017053 transcriptional repressor complex(GO:0017053)
0.2 0.7 GO:0033269 internode region of axon(GO:0033269)
0.1 56.7 GO:0005667 transcription factor complex(GO:0005667)
0.1 0.7 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.1 0.5 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 0.9 GO:0034518 mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.1 2.7 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 8.3 GO:0005604 basement membrane(GO:0005604)
0.1 17.2 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 0.3 GO:0097512 cardiac myofibril(GO:0097512)
0.1 0.7 GO:0034709 methylosome(GO:0034709)
0.1 6.9 GO:0030018 Z disc(GO:0030018)
0.1 1.7 GO:0035145 exon-exon junction complex(GO:0035145)
0.1 2.8 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 1.1 GO:0045171 intercellular bridge(GO:0045171)
0.0 0.4 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.4 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 2.3 GO:0031985 Golgi cisterna(GO:0031985)
0.0 0.7 GO:0010369 chromocenter(GO:0010369)
0.0 4.7 GO:0000922 spindle pole(GO:0000922)
0.0 0.8 GO:0035102 PRC1 complex(GO:0035102)
0.0 2.7 GO:0042734 presynaptic membrane(GO:0042734)
0.0 6.4 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 2.5 GO:0005912 adherens junction(GO:0005912)
0.0 2.2 GO:0022626 cytosolic ribosome(GO:0022626)
0.0 0.5 GO:0014704 intercalated disc(GO:0014704)
0.0 2.8 GO:0000793 condensed chromosome(GO:0000793)
0.0 0.7 GO:0005884 actin filament(GO:0005884)
0.0 6.5 GO:0005874 microtubule(GO:0005874)
0.0 0.8 GO:0005882 intermediate filament(GO:0005882)
0.0 1.8 GO:0030027 lamellipodium(GO:0030027)
0.0 0.5 GO:0016235 aggresome(GO:0016235)
0.0 0.3 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 11.1 GO:0005730 nucleolus(GO:0005730)
0.0 4.9 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 0.1 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.9 GO:0031012 extracellular matrix(GO:0031012)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
8.8 26.3 GO:0001042 RNA polymerase I core binding(GO:0001042)
6.4 25.8 GO:0004859 phospholipase inhibitor activity(GO:0004859) phospholipase A2 inhibitor activity(GO:0019834)
5.2 25.9 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
4.9 107.7 GO:0005520 insulin-like growth factor binding(GO:0005520)
3.7 22.2 GO:0015204 urea transmembrane transporter activity(GO:0015204)
3.6 10.7 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
2.7 35.2 GO:0045294 alpha-catenin binding(GO:0045294)
2.6 23.3 GO:0030274 LIM domain binding(GO:0030274)
2.3 6.9 GO:0030156 benzodiazepine receptor binding(GO:0030156)
2.1 27.8 GO:0005149 interleukin-1 receptor binding(GO:0005149)
2.1 29.5 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
2.1 22.9 GO:0097157 pre-mRNA intronic binding(GO:0097157)
1.9 5.6 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
1.3 11.9 GO:0008420 CTD phosphatase activity(GO:0008420)
1.2 16.2 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
1.1 15.3 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
1.0 4.0 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.9 3.7 GO:0005113 patched binding(GO:0005113)
0.9 8.3 GO:0043237 laminin-1 binding(GO:0043237)
0.8 2.4 GO:0042936 dipeptide transporter activity(GO:0042936)
0.8 6.9 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.8 5.3 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.7 2.2 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.7 3.5 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.7 8.7 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.6 14.0 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.6 2.3 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.6 3.5 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.6 1.1 GO:0038132 neuregulin binding(GO:0038132)
0.5 11.0 GO:0017049 GTP-Rho binding(GO:0017049)
0.5 5.6 GO:0035173 histone kinase activity(GO:0035173)
0.5 1.8 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.5 5.1 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
0.4 8.9 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.4 10.1 GO:0030371 translation repressor activity(GO:0030371)
0.4 2.4 GO:0050786 RAGE receptor binding(GO:0050786)
0.4 2.8 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.4 3.4 GO:0071253 connexin binding(GO:0071253)
0.4 9.4 GO:0034185 apolipoprotein binding(GO:0034185)
0.4 8.9 GO:0030506 ankyrin binding(GO:0030506)
0.4 1.1 GO:0047751 3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765) enone reductase activity(GO:0035671) cholestenone 5-alpha-reductase activity(GO:0047751)
0.4 1.5 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.3 2.2 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.3 1.8 GO:0001515 opioid peptide activity(GO:0001515)
0.3 1.2 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.3 2.6 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.3 2.0 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.3 13.8 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.3 11.6 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.2 4.0 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 29.1 GO:0003774 motor activity(GO:0003774)
0.2 5.4 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.2 2.0 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.2 2.1 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.2 7.2 GO:0005109 frizzled binding(GO:0005109)
0.2 2.5 GO:0030957 Tat protein binding(GO:0030957)
0.2 2.3 GO:0017166 vinculin binding(GO:0017166)
0.2 0.7 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.2 4.8 GO:0043014 alpha-tubulin binding(GO:0043014)
0.2 2.8 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.2 1.3 GO:0070739 protein-glutamic acid ligase activity(GO:0070739)
0.2 7.1 GO:0004407 histone deacetylase activity(GO:0004407)
0.2 0.9 GO:0047276 N-acetyllactosaminide 3-alpha-galactosyltransferase activity(GO:0047276)
0.1 2.8 GO:0005003 ephrin receptor activity(GO:0005003)
0.1 1.0 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.1 1.5 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 2.4 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.1 4.3 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 24.7 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 2.8 GO:0042805 actinin binding(GO:0042805)
0.1 0.7 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.1 16.1 GO:0005539 glycosaminoglycan binding(GO:0005539)
0.1 5.4 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 1.1 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.1 1.0 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 4.8 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 0.5 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.1 3.4 GO:0019894 kinesin binding(GO:0019894)
0.1 0.4 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.1 0.5 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 0.7 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 1.3 GO:0017160 Ral GTPase binding(GO:0017160)
0.1 4.4 GO:0035254 glutamate receptor binding(GO:0035254)
0.1 5.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 2.7 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 0.5 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.1 23.8 GO:0003779 actin binding(GO:0003779)
0.1 18.4 GO:0005096 GTPase activator activity(GO:0005096)
0.1 5.2 GO:0032947 protein complex scaffold(GO:0032947)
0.1 4.4 GO:0033613 activating transcription factor binding(GO:0033613)
0.1 1.6 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.1 0.7 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 1.1 GO:0030332 cyclin binding(GO:0030332)
0.0 2.8 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.1 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0 3.4 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 7.7 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 0.3 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.8 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.1 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.0 0.3 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 4.7 GO:0003924 GTPase activity(GO:0003924)
0.0 0.5 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 1.5 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.3 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 24.1 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
2.1 94.9 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
1.1 16.4 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.8 24.0 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.8 11.0 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.5 9.3 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.5 38.5 PID_AP1_PATHWAY AP-1 transcription factor network
0.4 12.3 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.4 11.9 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.4 24.2 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.4 11.2 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.3 12.9 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.3 16.2 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.2 2.8 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.2 5.6 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.2 28.2 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 1.4 PID_ALK2_PATHWAY ALK2 signaling events
0.2 6.9 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.1 2.6 PID_BMP_PATHWAY BMP receptor signaling
0.1 3.8 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.1 6.9 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.1 12.3 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 3.4 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.1 1.7 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 1.9 PID_SHP2_PATHWAY SHP2 signaling
0.1 2.5 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.1 4.9 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 3.9 PID_AVB3_INTEGRIN_PATHWAY Integrins in angiogenesis
0.1 2.4 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 2.5 ST_INTEGRIN_SIGNALING_PATHWAY Integrin Signaling Pathway
0.1 8.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.4 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.0 1.2 PID_ARF6_PATHWAY Arf6 signaling events
0.0 1.3 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 1.8 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 2.9 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.9 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 1.0 PID_AR_PATHWAY Coregulation of Androgen receptor activity

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 110.7 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
2.0 2.0 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
1.7 27.4 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
1.7 23.3 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
1.6 12.7 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
1.5 29.5 REACTOME_DESTABILIZATION_OF_MRNA_BY_BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
1.1 22.2 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.9 14.9 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.9 25.2 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.8 14.0 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.6 7.6 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.5 3.4 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.4 11.0 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.4 2.5 REACTOME_SIGNALING_BY_NOTCH2 Genes involved in Signaling by NOTCH2
0.3 18.8 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.3 8.7 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.3 10.0 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.3 0.9 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.3 10.7 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.3 10.8 REACTOME_G1_PHASE Genes involved in G1 Phase
0.3 3.9 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.3 4.8 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.2 3.7 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.2 1.1 REACTOME_ANDROGEN_BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.2 35.0 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.2 9.3 REACTOME_SIGNAL_TRANSDUCTION_BY_L1 Genes involved in Signal transduction by L1
0.2 2.4 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 2.2 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.1 4.3 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 3.6 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.1 2.6 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.1 2.9 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.1 2.7 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 5.2 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 1.9 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.1 1.6 REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI Genes involved in RIP-mediated NFkB activation via DAI
0.1 1.1 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.1 2.1 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 4.6 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 7.4 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 1.5 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 1.5 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 3.7 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.7 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.0 1.6 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.0 0.7 REACTOME_METABOLISM_OF_NON_CODING_RNA Genes involved in Metabolism of non-coding RNA
0.0 0.4 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis