Motif ID: Nkx2-5

Z-value: 0.868


Transcription factors associated with Nkx2-5:

Gene SymbolEntrez IDGene Name
Nkx2-5 ENSMUSG00000015579.4 Nkx2-5



Activity profile for motif Nkx2-5.

activity profile for motif Nkx2-5


Sorted Z-values histogram for motif Nkx2-5

Sorted Z-values for motif Nkx2-5



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-5

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_88978958 15.517 ENSMUST00000042594.6
ENSMUST00000109368.1
Mlc1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

chr8_-_46294592 6.701 ENSMUST00000058636.7
Helt
helt bHLH transcription factor
chr18_-_31949571 5.654 ENSMUST00000064016.5
Gpr17
G protein-coupled receptor 17
chr1_+_172341197 5.223 ENSMUST00000056136.3
Kcnj10
potassium inwardly-rectifying channel, subfamily J, member 10
chr14_+_80000292 3.480 ENSMUST00000088735.3
Olfm4
olfactomedin 4
chr4_+_103619580 3.260 ENSMUST00000106827.1
Dab1
disabled 1
chr12_+_74297474 2.682 ENSMUST00000072100.3
Dbpht2
DNA binding protein with his-thr domain
chr6_-_101377342 2.366 ENSMUST00000151175.1
Pdzrn3
PDZ domain containing RING finger 3
chr8_+_124793061 2.255 ENSMUST00000041106.7
Trim67
tripartite motif-containing 67
chr15_-_10470490 2.046 ENSMUST00000136591.1
Dnajc21
DnaJ (Hsp40) homolog, subfamily C, member 21
chr12_+_37880700 2.029 ENSMUST00000040500.7
Dgkb
diacylglycerol kinase, beta
chr12_+_91400990 1.880 ENSMUST00000021346.7
ENSMUST00000021343.6
Tshr

thyroid stimulating hormone receptor

chr2_+_131234043 1.799 ENSMUST00000041362.5
ENSMUST00000110199.2
Mavs

mitochondrial antiviral signaling protein

chr9_-_53536608 1.693 ENSMUST00000150244.1
Atm
ataxia telangiectasia mutated homolog (human)
chr15_-_33405976 1.670 ENSMUST00000079057.6
1700084J12Rik
RIKEN cDNA 1700084J12 gene
chr2_+_52038005 1.500 ENSMUST00000065927.5
Tnfaip6
tumor necrosis factor alpha induced protein 6
chr19_-_57360668 1.478 ENSMUST00000181921.1
B230217O12Rik
RIKEN cDNA B230217O12 gene
chr13_+_30136498 1.358 ENSMUST00000047311.8
Mboat1
membrane bound O-acyltransferase domain containing 1
chr9_+_98422961 1.337 ENSMUST00000052068.9
Rbp1
retinol binding protein 1, cellular
chr19_+_26753588 1.333 ENSMUST00000177116.1
Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr5_+_138085083 1.222 ENSMUST00000019660.4
ENSMUST00000066617.5
ENSMUST00000110963.1
Zkscan1


zinc finger with KRAB and SCAN domains 1


chrX_-_75416533 1.201 ENSMUST00000033542.4
Mtcp1
mature T cell proliferation 1
chr11_-_78550777 1.184 ENSMUST00000103242.4
Tmem97
transmembrane protein 97
chr2_-_173276144 1.114 ENSMUST00000139306.1
Pmepa1
prostate transmembrane protein, androgen induced 1
chr5_-_124327812 1.007 ENSMUST00000184951.1
Mphosph9
M-phase phosphoprotein 9
chr4_+_42714926 0.901 ENSMUST00000178454.1
Gm21955
predicted gene, 21955
chr12_+_103314944 0.892 ENSMUST00000179363.1
Fam181a
family with sequence similarity 181, member A
chr15_-_82224330 0.879 ENSMUST00000089161.2
ENSMUST00000109535.2
Tnfrsf13c

tumor necrosis factor receptor superfamily, member 13c

chr18_-_79109391 0.871 ENSMUST00000025430.8
ENSMUST00000161465.2
Setbp1

SET binding protein 1

chr2_+_174076296 0.834 ENSMUST00000155000.1
ENSMUST00000134876.1
ENSMUST00000147038.1
Stx16


syntaxin 16


chr1_-_66817536 0.830 ENSMUST00000068168.3
ENSMUST00000113987.1
Kansl1l

KAT8 regulatory NSL complex subunit 1-like

chr11_-_101987004 0.817 ENSMUST00000107173.2
ENSMUST00000107172.1
Dusp3

dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)

chr6_-_115853346 0.787 ENSMUST00000032469.6
Mbd4
methyl-CpG binding domain protein 4
chr4_-_87806276 0.763 ENSMUST00000148059.1
Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr19_-_40271506 0.762 ENSMUST00000068439.6
Pdlim1
PDZ and LIM domain 1 (elfin)
chr17_+_35379608 0.745 ENSMUST00000081435.4
H2-Q4
histocompatibility 2, Q region locus 4
chr4_-_87806296 0.719 ENSMUST00000126353.1
ENSMUST00000149357.1
Mllt3

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

chr14_+_47001336 0.714 ENSMUST00000125113.1
Samd4
sterile alpha motif domain containing 4
chr7_-_126897424 0.684 ENSMUST00000120007.1
Tmem219
transmembrane protein 219
chr17_+_88440711 0.651 ENSMUST00000112238.2
ENSMUST00000155640.1
Foxn2

forkhead box N2

chr16_+_44139821 0.629 ENSMUST00000159514.1
ENSMUST00000161326.1
ENSMUST00000063520.8
ENSMUST00000063542.7
Naa50



N(alpha)-acetyltransferase 50, NatE catalytic subunit



chr5_-_124327883 0.597 ENSMUST00000031344.6
Mphosph9
M-phase phosphoprotein 9
chr16_+_44943737 0.566 ENSMUST00000114622.3
ENSMUST00000166731.1
Cd200r3

CD200 receptor 3

chr4_-_108625216 0.561 ENSMUST00000166069.1
Gm20731
predicted gene, 20731
chr12_+_4082596 0.558 ENSMUST00000049584.5
Dnajc27
DnaJ (Hsp40) homolog, subfamily C, member 27
chr11_+_4620067 0.552 ENSMUST00000109941.1
Gm11032
predicted gene 11032
chr14_+_51893610 0.545 ENSMUST00000047726.5
ENSMUST00000161888.1
Slc39a2

solute carrier family 39 (zinc transporter), member 2

chr17_-_29716969 0.536 ENSMUST00000129091.1
ENSMUST00000128751.1
Ccdc167

coiled-coil domain containing 167

chr4_-_140323302 0.518 ENSMUST00000063789.2
Gm9867
predicted gene 9867
chr7_+_128246812 0.516 ENSMUST00000164710.1
ENSMUST00000070656.5
Tgfb1i1

transforming growth factor beta 1 induced transcript 1

chr15_-_54919961 0.502 ENSMUST00000167541.2
ENSMUST00000041591.9
ENSMUST00000173516.1
Enpp2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr1_-_86359455 0.497 ENSMUST00000027438.6
Ncl
nucleolin
chr18_+_49832622 0.496 ENSMUST00000180611.1
Dmxl1
Dmx-like 1
chr4_+_137594140 0.491 ENSMUST00000105840.1
ENSMUST00000055131.6
ENSMUST00000105839.1
ENSMUST00000105838.1
Usp48



ubiquitin specific peptidase 48



chrX_-_75416562 0.473 ENSMUST00000114081.1
ENSMUST00000033543.7
ENSMUST00000149863.2
Mtcp1
Mtcp1

mature T cell proliferation 1
mature T cell proliferation 1

chr5_-_8997324 0.472 ENSMUST00000003720.4
Crot
carnitine O-octanoyltransferase
chr12_+_4082574 0.469 ENSMUST00000020986.7
Dnajc27
DnaJ (Hsp40) homolog, subfamily C, member 27
chr4_+_62619515 0.466 ENSMUST00000084521.4
ENSMUST00000107424.1
Rgs3

regulator of G-protein signaling 3

chr2_-_127792467 0.453 ENSMUST00000135091.1
1500011K16Rik
RIKEN cDNA 1500011K16 gene
chr2_-_5942740 0.436 ENSMUST00000026924.5
ENSMUST00000095147.2
ENSMUST00000169865.1
Dhtkd1


dehydrogenase E1 and transketolase domain containing 1


chr6_+_42286709 0.396 ENSMUST00000163936.1
Clcn1
chloride channel 1
chr9_+_57940104 0.392 ENSMUST00000043059.7
Sema7a
sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
chr1_+_128103297 0.388 ENSMUST00000036288.4
R3hdm1
R3H domain containing 1
chr1_-_163725123 0.362 ENSMUST00000159679.1
Mettl11b
methyltransferase like 11B
chr4_+_148000722 0.358 ENSMUST00000103230.4
Nppa
natriuretic peptide type A
chr13_+_30136529 0.353 ENSMUST00000152798.1
Mboat1
membrane bound O-acyltransferase domain containing 1
chr17_-_56609689 0.348 ENSMUST00000052832.5
2410015M20Rik
RIKEN cDNA 2410015M20 gene
chr8_+_113643206 0.314 ENSMUST00000034219.4
ENSMUST00000095173.1
Syce1l

synaptonemal complex central element protein 1 like

chr3_-_89160155 0.313 ENSMUST00000029686.3
Hcn3
hyperpolarization-activated, cyclic nucleotide-gated K+ 3
chr8_+_3631109 0.300 ENSMUST00000004745.8
Stxbp2
syntaxin binding protein 2
chr4_-_126968124 0.297 ENSMUST00000106108.2
Zmym4
zinc finger, MYM-type 4
chr16_-_44139630 0.291 ENSMUST00000137557.1
ENSMUST00000147025.1
Atp6v1a

ATPase, H+ transporting, lysosomal V1 subunit A

chr7_+_128246953 0.272 ENSMUST00000167965.1
Tgfb1i1
transforming growth factor beta 1 induced transcript 1
chr9_+_44772951 0.271 ENSMUST00000128150.1
Ift46
intraflagellar transport 46
chr10_-_42018363 0.251 ENSMUST00000162405.1
ENSMUST00000095729.4
ENSMUST00000161081.1
ENSMUST00000160262.2
Armc2



armadillo repeat containing 2



chr15_-_54920115 0.247 ENSMUST00000171545.1
Enpp2
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr19_+_8819401 0.247 ENSMUST00000096753.3
Hnrnpul2
heterogeneous nuclear ribonucleoprotein U-like 2
chr16_+_44173271 0.244 ENSMUST00000088356.4
ENSMUST00000169582.1
Gm608

predicted gene 608

chr2_+_23069210 0.234 ENSMUST00000155602.1
Acbd5
acyl-Coenzyme A binding domain containing 5
chr6_+_14901440 0.229 ENSMUST00000128567.1
Foxp2
forkhead box P2
chr3_-_153725062 0.226 ENSMUST00000064460.5
St6galnac3
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
chr15_-_99457712 0.202 ENSMUST00000161948.1
Nckap5l
NCK-associated protein 5-like
chr6_+_115853470 0.198 ENSMUST00000112925.1
ENSMUST00000112923.1
ENSMUST00000038234.6
Ift122


intraflagellar transport 122


chr7_+_29071597 0.190 ENSMUST00000180926.1
Gm26604
predicted gene, 26604
chr7_+_43690418 0.160 ENSMUST00000056329.6
Klk14
kallikrein related-peptidase 14
chr9_+_44773027 0.156 ENSMUST00000125877.1
Ift46
intraflagellar transport 46
chr10_-_127311740 0.128 ENSMUST00000037290.5
ENSMUST00000171564.1
Mars

methionine-tRNA synthetase

chr15_-_99457742 0.123 ENSMUST00000023747.7
Nckap5l
NCK-associated protein 5-like
chr11_-_115603866 0.108 ENSMUST00000125097.1
ENSMUST00000106508.3
ENSMUST00000019135.7
Gga3


golgi associated, gamma adaptin ear containing, ARF binding protein 3


chr7_+_18991245 0.105 ENSMUST00000130268.1
ENSMUST00000059331.8
ENSMUST00000131087.1
Mypop


Myb-related transcription factor, partner of profilin


chr2_+_32288317 0.091 ENSMUST00000131712.1
ENSMUST00000133113.1
ENSMUST00000081670.6
ENSMUST00000147707.1
ENSMUST00000129193.1
Golga2




golgi autoantigen, golgin subfamily a, 2




chr3_+_52268337 0.076 ENSMUST00000053764.5
Foxo1
forkhead box O1
chr2_+_120609383 0.074 ENSMUST00000124187.1
Haus2
HAUS augmin-like complex, subunit 2
chr5_-_106624390 0.051 ENSMUST00000112694.1
Zfp644
zinc finger protein 644
chr2_+_69897220 0.043 ENSMUST00000055758.9
ENSMUST00000112251.2
Ubr3

ubiquitin protein ligase E3 component n-recognin 3

chr8_-_95113334 0.010 ENSMUST00000169353.1
Kifc3
kinesin family member C3
chr11_+_101155884 0.010 ENSMUST00000043654.9
Tubg2
tubulin, gamma 2
chr11_-_3976778 0.006 ENSMUST00000042344.1
4930556J24Rik
RIKEN cDNA 4930556J24 gene
chr14_+_20674311 0.004 ENSMUST00000048657.8
Sec24c
Sec24 related gene family, member C (S. cerevisiae)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 15.5 GO:0047484 regulation of response to osmotic stress(GO:0047484) cellular response to cholesterol(GO:0071397)
1.3 5.2 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
1.1 3.3 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.9 1.8 GO:0071649 regulation of chemokine (C-C motif) ligand 5 production(GO:0071649)
0.7 5.7 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.6 1.7 GO:0002331 pre-B cell allelic exclusion(GO:0002331) signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434) regulation of microglial cell activation(GO:1903978) telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
0.4 6.7 GO:0097154 GABAergic neuron differentiation(GO:0097154)
0.3 1.0 GO:0045204 MAPK export from nucleus(GO:0045204)
0.3 1.3 GO:0006776 vitamin A metabolic process(GO:0006776)
0.3 1.9 GO:1904587 response to glycoprotein(GO:1904587)
0.3 0.9 GO:0002636 positive regulation of germinal center formation(GO:0002636)
0.2 1.1 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.1 1.3 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.1 0.7 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.1 0.8 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.1 1.5 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1 2.3 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.1 0.4 GO:1903764 regulation of potassium ion export across plasma membrane(GO:1903764)
0.1 3.5 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1 2.0 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.1 0.6 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.1 0.6 GO:1901838 positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838)
0.1 0.5 GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.1 0.3 GO:0007128 meiotic prophase I(GO:0007128) prophase(GO:0051324)
0.1 0.8 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.2 GO:0007227 signal transduction downstream of smoothened(GO:0007227) ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830) embryonic heart tube left/right pattern formation(GO:0060971)
0.0 0.9 GO:0090161 Golgi ribbon formation(GO:0090161)
0.0 0.5 GO:0051791 medium-chain fatty acid metabolic process(GO:0051791)
0.0 0.4 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.0 0.4 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.2 GO:0030242 pexophagy(GO:0030242)
0.0 0.6 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.7 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.2 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.0 0.2 GO:0007320 insemination(GO:0007320)
0.0 0.3 GO:0042407 cristae formation(GO:0042407)
0.0 0.3 GO:0033008 positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of mast cell degranulation(GO:0043306)
0.0 1.2 GO:0007528 neuromuscular junction development(GO:0007528)
0.0 1.2 GO:0042632 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.0 0.7 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.0 0.4 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.0 1.5 GO:0050728 negative regulation of inflammatory response(GO:0050728)
0.0 0.5 GO:0006829 zinc II ion transport(GO:0006829)
0.0 0.4 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 0.0 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.5 GO:0097449 astrocyte projection(GO:0097449)
0.3 3.8 GO:0042581 specific granule(GO:0042581)
0.1 15.5 GO:0005901 caveola(GO:0005901)
0.1 0.5 GO:0001651 dense fibrillar component(GO:0001651)
0.1 0.6 GO:0031415 NatA complex(GO:0031415)
0.1 1.3 GO:0071564 npBAF complex(GO:0071564)
0.1 0.3 GO:0044316 cone cell pedicle(GO:0044316)
0.1 0.7 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.4 GO:0042629 mast cell granule(GO:0042629)
0.0 0.4 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.3 GO:0061617 MICOS complex(GO:0061617)
0.0 1.7 GO:1990391 DNA repair complex(GO:1990391)
0.0 0.3 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 1.5 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 2.4 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.8 GO:0001772 immunological synapse(GO:0001772)
0.0 3.3 GO:0005903 brush border(GO:0005903)
0.0 0.2 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 1.1 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.8 GO:0031201 SNARE complex(GO:0031201)
0.0 7.4 GO:0005667 transcription factor complex(GO:0005667)
0.0 1.2 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 1.6 GO:0005814 centriole(GO:0005814)
0.0 0.1 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.8 GO:0000123 histone acetyltransferase complex(GO:0000123)
0.0 2.4 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 0.3 GO:0000795 synaptonemal complex(GO:0000795)
0.0 1.8 GO:0009897 external side of plasma membrane(GO:0009897)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.2 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.6 1.7 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.4 1.8 GO:0050700 CARD domain binding(GO:0050700)
0.2 1.3 GO:0019841 retinol binding(GO:0019841)
0.2 0.8 GO:0000700 mismatch base pair DNA N-glycosylase activity(GO:0000700)
0.2 0.7 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.2 2.0 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.2 1.9 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 15.5 GO:0008565 protein transporter activity(GO:0008565)
0.1 0.5 GO:0042134 rRNA primary transcript binding(GO:0042134)
0.1 0.8 GO:0048495 Roundabout binding(GO:0048495)
0.1 1.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 0.3 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.1 0.3 GO:0030348 syntaxin-3 binding(GO:0030348)
0.1 3.3 GO:0042169 SH2 domain binding(GO:0042169)
0.1 0.4 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1 0.7 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.0 0.8 GO:0033549 MAP kinase phosphatase activity(GO:0033549)
0.0 0.5 GO:0016406 carnitine O-acyltransferase activity(GO:0016406)
0.0 0.8 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 0.6 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 6.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.2 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 1.1 GO:0050699 WW domain binding(GO:0050699)
0.0 0.4 GO:0038191 neuropilin binding(GO:0038191)
0.0 1.3 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.4 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.4 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 0.7 GO:0030371 translation repressor activity(GO:0030371)
0.0 0.5 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.8 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 2.8 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.0 0.3 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.1 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 0.1 GO:0061676 importin-alpha family protein binding(GO:0061676)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.3 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 1.7 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 1.9 PID_ARF6_PATHWAY Arf6 signaling events
0.0 1.3 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 1.4 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 0.5 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.5 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.7 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.6 1.9 REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS Genes involved in Hormone ligand-binding receptors
0.2 1.7 REACTOME_ACYL_CHAIN_REMODELLING_OF_PS Genes involved in Acyl chain remodelling of PS
0.2 1.7 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 5.2 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 1.8 REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.1 0.8 REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.1 0.8 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 2.0 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 0.8 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.0 1.1 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.5 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.2 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.4 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.5 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.3 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 0.4 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression