Motif ID: Hoxb1

Z-value: 0.610


Transcription factors associated with Hoxb1:

Gene SymbolEntrez IDGene Name
Hoxb1 ENSMUSG00000018973.2 Hoxb1



Activity profile for motif Hoxb1.

activity profile for motif Hoxb1


Sorted Z-values histogram for motif Hoxb1

Sorted Z-values for motif Hoxb1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_119053339 3.853 ENSMUST00000161301.1
ENSMUST00000161451.1
ENSMUST00000162607.1
Gli2


GLI-Kruppel family member GLI2


chr1_+_127306706 2.701 ENSMUST00000171405.1
Mgat5
mannoside acetylglucosaminyltransferase 5
chr5_+_139543889 2.053 ENSMUST00000174792.1
ENSMUST00000031523.8
Uncx

UNC homeobox

chr3_+_127633134 1.996 ENSMUST00000029587.7
Neurog2
neurogenin 2
chr1_+_153665274 1.879 ENSMUST00000152114.1
ENSMUST00000111812.1
Rgs8

regulator of G-protein signaling 8

chr1_-_135688094 1.720 ENSMUST00000112103.1
Nav1
neuron navigator 1
chr2_+_124610573 1.603 ENSMUST00000103239.3
ENSMUST00000103240.2
Sema6d

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D

chr19_-_41743665 1.553 ENSMUST00000025993.3
Slit1
slit homolog 1 (Drosophila)
chr2_+_124610278 1.528 ENSMUST00000051419.8
ENSMUST00000077847.5
ENSMUST00000078621.5
ENSMUST00000076335.5
Sema6d



sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D



chr8_-_8639363 1.467 ENSMUST00000152698.1
Efnb2
ephrin B2
chr2_+_65845833 1.456 ENSMUST00000053910.3
Csrnp3
cysteine-serine-rich nuclear protein 3
chrX_+_143518671 1.367 ENSMUST00000134402.1
Pak3
p21 protein (Cdc42/Rac)-activated kinase 3
chr1_-_119053619 1.267 ENSMUST00000062483.8
Gli2
GLI-Kruppel family member GLI2
chr10_-_92162753 1.249 ENSMUST00000182197.1
Rmst
rhabdomyosarcoma 2 associated transcript (non-coding RNA)
chr8_-_87959560 1.184 ENSMUST00000109655.2
Zfp423
zinc finger protein 423
chr7_+_73391160 0.955 ENSMUST00000128471.1
Rgma
RGM domain family, member A
chr4_-_91399984 0.858 ENSMUST00000102799.3
Elavl2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr9_-_91365778 0.825 ENSMUST00000065360.3
Zic1
zinc finger protein of the cerebellum 1
chr12_-_15816762 0.808 ENSMUST00000020922.7
Trib2
tribbles homolog 2 (Drosophila)
chr3_-_88762244 0.738 ENSMUST00000183267.1
Syt11
synaptotagmin XI
chr9_-_91365756 0.675 ENSMUST00000034927.6
Zic1
zinc finger protein of the cerebellum 1
chr2_+_119972699 0.652 ENSMUST00000066058.7
Mapkbp1
mitogen-activated protein kinase binding protein 1
chr10_-_33624587 0.640 ENSMUST00000160299.1
ENSMUST00000019920.6
Clvs2

clavesin 2

chr11_+_75486813 0.628 ENSMUST00000018449.4
ENSMUST00000102510.1
ENSMUST00000131283.1
Prpf8


pre-mRNA processing factor 8


chr4_-_35845204 0.604 ENSMUST00000164772.1
ENSMUST00000065173.2
Lingo2

leucine rich repeat and Ig domain containing 2

chr14_-_69503316 0.596 ENSMUST00000179116.2
Gm21464
predicted gene, 21464
chr1_-_157412576 0.595 ENSMUST00000078308.6
ENSMUST00000139470.1
Rasal2

RAS protein activator like 2

chr17_+_26941420 0.590 ENSMUST00000081285.3
ENSMUST00000177932.1
Syngap1

synaptic Ras GTPase activating protein 1 homolog (rat)

chr5_-_24527276 0.569 ENSMUST00000088311.4
Gbx1
gastrulation brain homeobox 1
chr6_-_136875794 0.550 ENSMUST00000032342.1
Mgp
matrix Gla protein
chr8_+_84901928 0.541 ENSMUST00000067060.7
Klf1
Kruppel-like factor 1 (erythroid)
chr14_-_69503220 0.532 ENSMUST00000180059.2
Gm21464
predicted gene, 21464
chr18_-_56562187 0.529 ENSMUST00000171844.2
Aldh7a1
aldehyde dehydrogenase family 7, member A1
chr18_-_56562215 0.513 ENSMUST00000170309.1
Aldh7a1
aldehyde dehydrogenase family 7, member A1
chr2_+_84840612 0.504 ENSMUST00000111625.1
Slc43a1
solute carrier family 43, member 1
chr1_+_178798438 0.493 ENSMUST00000160789.1
Kif26b
kinesin family member 26B
chr5_-_107289561 0.481 ENSMUST00000031224.8
Tgfbr3
transforming growth factor, beta receptor III
chr10_+_4266323 0.453 ENSMUST00000045730.5
Akap12
A kinase (PRKA) anchor protein (gravin) 12
chr2_-_153529941 0.436 ENSMUST00000035346.7
8430427H17Rik
RIKEN cDNA 8430427H17 gene
chr4_+_43669610 0.412 ENSMUST00000107866.1
Tmem8b
transmembrane protein 8B
chr1_-_45503282 0.400 ENSMUST00000086430.4
Col5a2
collagen, type V, alpha 2
chr10_+_127677064 0.389 ENSMUST00000118612.1
ENSMUST00000048099.4
Tmem194

transmembrane protein 194

chr7_+_119690026 0.387 ENSMUST00000047045.8
Acsm4
acyl-CoA synthetase medium-chain family member 4
chr5_+_19907774 0.378 ENSMUST00000115267.2
Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr7_+_48789003 0.343 ENSMUST00000118927.1
ENSMUST00000125280.1
Zdhhc13

zinc finger, DHHC domain containing 13

chr4_-_63662910 0.329 ENSMUST00000184252.1
Gm11214
predicted gene 11214
chr11_+_85353156 0.324 ENSMUST00000108061.1
ENSMUST00000108062.1
ENSMUST00000108056.1
ENSMUST00000138423.1
ENSMUST00000074875.4
ENSMUST00000092821.3
Bcas3





breast carcinoma amplified sequence 3





chr11_-_40755201 0.324 ENSMUST00000020576.7
Ccng1
cyclin G1
chr4_+_103114712 0.298 ENSMUST00000143417.1
Mier1
mesoderm induction early response 1 homolog (Xenopus laevis
chr12_+_38780284 0.283 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
Etv1


ets variant gene 1


chr3_-_58525867 0.269 ENSMUST00000029385.7
Serp1
stress-associated endoplasmic reticulum protein 1
chr17_+_29490812 0.260 ENSMUST00000024811.6
Pim1
proviral integration site 1
chr8_+_25808474 0.243 ENSMUST00000033979.4
Star
steroidogenic acute regulatory protein
chr11_-_83298873 0.243 ENSMUST00000175741.1
ENSMUST00000176518.1
Pex12

peroxisomal biogenesis factor 12

chr2_+_65845767 0.225 ENSMUST00000122912.1
Csrnp3
cysteine-serine-rich nuclear protein 3
chr18_-_56562261 0.221 ENSMUST00000066208.6
ENSMUST00000172734.1
Aldh7a1

aldehyde dehydrogenase family 7, member A1

chrX_+_110814390 0.201 ENSMUST00000078229.3
Pou3f4
POU domain, class 3, transcription factor 4
chr16_-_56024628 0.173 ENSMUST00000119981.1
ENSMUST00000096021.3
Pcnp

PEST proteolytic signal containing nuclear protein

chr15_+_89253035 0.166 ENSMUST00000088788.3
Ppp6r2
protein phosphatase 6, regulatory subunit 2
chr6_-_124464772 0.153 ENSMUST00000008297.4
Clstn3
calsyntenin 3
chr9_-_108083330 0.135 ENSMUST00000159372.1
ENSMUST00000160249.1
Rnf123

ring finger protein 123

chr17_+_34647128 0.135 ENSMUST00000015605.8
ENSMUST00000182587.1
Atf6b

activating transcription factor 6 beta

chr2_+_147012996 0.128 ENSMUST00000028921.5
Xrn2
5'-3' exoribonuclease 2
chr4_+_118428078 0.110 ENSMUST00000006557.6
ENSMUST00000167636.1
ENSMUST00000102673.4
Elovl1


elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1


chr17_+_34647187 0.106 ENSMUST00000173984.1
Atf6b
activating transcription factor 6 beta
chr3_+_58526303 0.092 ENSMUST00000138848.1
Eif2a
eukaryotic translation initiation factor 2A
chr5_+_37735519 0.062 ENSMUST00000073554.3
Cytl1
cytokine-like 1
chr1_+_39535747 0.058 ENSMUST00000003219.8
Cnot11
CCR4-NOT transcription complex, subunit 11
chrX_+_20617503 0.050 ENSMUST00000115375.1
ENSMUST00000115374.1
ENSMUST00000084383.3
Rbm10


RNA binding motif protein 10


chr15_-_95528702 0.039 ENSMUST00000166170.1
Nell2
NEL-like 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 5.1 GO:0060032 notochord regression(GO:0060032)
0.3 2.1 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.2 0.7 GO:1990927 negative regulation of membrane invagination(GO:1905154) calcium ion regulated lysosome exocytosis(GO:1990927)
0.2 1.6 GO:0033563 dorsal/ventral axon guidance(GO:0033563)
0.2 1.5 GO:1903847 regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.2 0.5 GO:0072092 ureteric bud invasion(GO:0072092)
0.2 0.5 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
0.1 0.6 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.1 1.9 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.1 0.4 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.1 0.7 GO:0007256 activation of JNKK activity(GO:0007256)
0.1 3.1 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.1 1.0 GO:1900121 negative regulation of receptor binding(GO:1900121)
0.1 0.8 GO:0032693 negative regulation of interleukin-10 production(GO:0032693)
0.1 0.2 GO:0070859 positive regulation of bile acid biosynthetic process(GO:0070859) positive regulation of bile acid metabolic process(GO:1904253)
0.1 0.5 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.1 1.4 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.1 0.6 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 0.3 GO:2000138 positive regulation of cell proliferation involved in heart morphogenesis(GO:2000138)
0.0 0.5 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 1.2 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 2.7 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 0.3 GO:0060124 positive regulation of growth hormone secretion(GO:0060124)
0.0 0.3 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 0.2 GO:1902474 positive regulation of protein localization to synapse(GO:1902474)
0.0 0.2 GO:2001053 regulation of mesenchymal cell apoptotic process(GO:2001053) negative regulation of mesenchymal cell apoptotic process(GO:2001054)
0.0 1.5 GO:0007628 adult walking behavior(GO:0007628)
0.0 1.7 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 1.2 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.0 0.3 GO:0051895 negative regulation of focal adhesion assembly(GO:0051895)
0.0 0.2 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.0 2.0 GO:0021954 central nervous system neuron development(GO:0021954)
0.0 1.6 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 0.3 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.5 GO:0015804 neutral amino acid transport(GO:0015804)
0.0 0.2 GO:0016558 protein import into peroxisome matrix(GO:0016558)
0.0 0.2 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.0 0.1 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 5.1 GO:0097542 ciliary tip(GO:0097542)
0.2 0.5 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.1 0.4 GO:0005588 collagen type V trimer(GO:0005588)
0.1 1.2 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 0.7 GO:0032009 early phagosome(GO:0032009)
0.1 0.2 GO:1990415 Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429)
0.1 1.3 GO:0005682 U5 snRNP(GO:0005682)
0.1 1.9 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 1.7 GO:0043194 axon initial segment(GO:0043194)
0.0 0.2 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.3 GO:0035327 transcriptionally active chromatin(GO:0035327)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.7 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.3 1.3 GO:0008802 betaine-aldehyde dehydrogenase activity(GO:0008802)
0.2 0.6 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.2 1.6 GO:0048495 Roundabout binding(GO:0048495)
0.2 3.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 5.0 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 0.4 GO:0003996 acyl-CoA ligase activity(GO:0003996)
0.1 0.3 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.1 1.0 GO:1990459 transferrin receptor binding(GO:1990459)
0.1 1.4 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 0.8 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.1 0.5 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.0 1.9 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.1 GO:0004534 transcription termination site sequence-specific DNA binding(GO:0001147) transcription termination site DNA binding(GO:0001160) 5'-3' exoribonuclease activity(GO:0004534)
0.0 2.0 GO:0070888 E-box binding(GO:0070888)
0.0 1.0 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 1.5 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.5 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.6 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.3 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.0 0.3 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.2 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.7 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 0.2 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.2 GO:0017127 cholesterol transporter activity(GO:0017127)
0.0 0.5 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 0.1 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.1 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.4 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.0 1.5 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 1.6 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 3.1 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.3 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 1.0 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.6 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.6 PID_RAS_PATHWAY Regulation of Ras family activation

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.7 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.1 3.1 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 2.5 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 0.2 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.0 0.5 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 1.9 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.0 0.6 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway