Motif ID: Nr4a3
Z-value: 0.716

Transcription factors associated with Nr4a3:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Nr4a3 | ENSMUSG00000028341.3 | Nr4a3 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Nr4a3 | mm10_v2_chr4_+_48045144_48045160 | 0.08 | 6.3e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.1 | 8.4 | GO:2000974 | negative regulation of pro-B cell differentiation(GO:2000974) |
0.8 | 6.1 | GO:0071557 | histone H3-K27 demethylation(GO:0071557) |
0.3 | 0.8 | GO:0046544 | regulation of natural killer cell proliferation(GO:0032817) positive regulation of natural killer cell proliferation(GO:0032819) development of secondary male sexual characteristics(GO:0046544) |
0.2 | 0.6 | GO:0045204 | MAPK export from nucleus(GO:0045204) |
0.2 | 0.9 | GO:0032237 | activation of store-operated calcium channel activity(GO:0032237) |
0.2 | 1.3 | GO:2000348 | regulation of CD40 signaling pathway(GO:2000348) |
0.2 | 1.2 | GO:0033184 | positive regulation of histone ubiquitination(GO:0033184) |
0.1 | 2.0 | GO:0006388 | tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388) |
0.1 | 0.7 | GO:1902947 | regulation of tau-protein kinase activity(GO:1902947) |
0.1 | 1.0 | GO:0019388 | galactose catabolic process(GO:0019388) |
0.1 | 0.7 | GO:0030644 | cellular chloride ion homeostasis(GO:0030644) |
0.1 | 2.1 | GO:2000060 | positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060) |
0.1 | 0.3 | GO:0015786 | UDP-glucose transport(GO:0015786) |
0.1 | 2.6 | GO:0000038 | very long-chain fatty acid metabolic process(GO:0000038) |
0.1 | 0.2 | GO:2000331 | regulation of terminal button organization(GO:2000331) |
0.1 | 0.3 | GO:0003360 | brainstem development(GO:0003360) |
0.0 | 0.8 | GO:0006264 | mitochondrial DNA replication(GO:0006264) |
0.0 | 1.2 | GO:0051560 | mitochondrial calcium ion homeostasis(GO:0051560) |
0.0 | 0.1 | GO:0098886 | modification of dendritic spine(GO:0098886) |
0.0 | 0.4 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
0.0 | 0.1 | GO:0042776 | mitochondrial ATP synthesis coupled proton transport(GO:0042776) |
0.0 | 0.2 | GO:0034196 | acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197) |
0.0 | 0.2 | GO:0014874 | response to stimulus involved in regulation of muscle adaptation(GO:0014874) |
0.0 | 2.8 | GO:0051489 | regulation of filopodium assembly(GO:0051489) |
0.0 | 1.1 | GO:0006379 | mRNA cleavage(GO:0006379) |
0.0 | 0.9 | GO:0001964 | startle response(GO:0001964) |
0.0 | 0.2 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
0.0 | 0.9 | GO:0032467 | positive regulation of cytokinesis(GO:0032467) |
0.0 | 0.3 | GO:0036158 | outer dynein arm assembly(GO:0036158) |
0.0 | 1.2 | GO:0045600 | positive regulation of fat cell differentiation(GO:0045600) |
0.0 | 0.1 | GO:0050787 | glycolate metabolic process(GO:0009441) enzyme active site formation via L-cysteine sulfinic acid(GO:0018323) primary alcohol biosynthetic process(GO:0034309) cellular response to glyoxal(GO:0036471) glycolate biosynthetic process(GO:0046295) detoxification of mercury ion(GO:0050787) negative regulation of TRAIL-activated apoptotic signaling pathway(GO:1903122) regulation of pyrroline-5-carboxylate reductase activity(GO:1903167) positive regulation of pyrroline-5-carboxylate reductase activity(GO:1903168) regulation of tyrosine 3-monooxygenase activity(GO:1903176) positive regulation of tyrosine 3-monooxygenase activity(GO:1903178) L-dopa metabolic process(GO:1903184) L-dopa biosynthetic process(GO:1903185) glyoxal metabolic process(GO:1903189) regulation of L-dopa biosynthetic process(GO:1903195) positive regulation of L-dopa biosynthetic process(GO:1903197) regulation of L-dopa decarboxylase activity(GO:1903198) positive regulation of L-dopa decarboxylase activity(GO:1903200) positive regulation of cellular amino acid biosynthetic process(GO:2000284) |
0.0 | 0.2 | GO:1903351 | response to dopamine(GO:1903350) cellular response to dopamine(GO:1903351) |
0.0 | 0.3 | GO:0010155 | regulation of proton transport(GO:0010155) |
0.0 | 0.1 | GO:1901097 | negative regulation of autophagosome maturation(GO:1901097) |
0.0 | 2.6 | GO:0031032 | actomyosin structure organization(GO:0031032) |
0.0 | 0.2 | GO:0042753 | positive regulation of circadian rhythm(GO:0042753) |
0.0 | 0.2 | GO:0006491 | N-glycan processing(GO:0006491) |
0.0 | 0.2 | GO:0030150 | protein import into mitochondrial matrix(GO:0030150) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 0.9 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
0.1 | 0.3 | GO:0097059 | CNTFR-CLCF1 complex(GO:0097059) |
0.1 | 0.9 | GO:0030057 | desmosome(GO:0030057) |
0.0 | 0.8 | GO:0042575 | DNA polymerase complex(GO:0042575) |
0.0 | 0.7 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
0.0 | 0.3 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) |
0.0 | 0.4 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
0.0 | 0.6 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
0.0 | 0.1 | GO:0097444 | spine apparatus(GO:0097444) |
0.0 | 0.3 | GO:0072546 | ER membrane protein complex(GO:0072546) |
0.0 | 1.2 | GO:0031902 | late endosome membrane(GO:0031902) |
0.0 | 0.3 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
0.0 | 1.4 | GO:0016459 | myosin complex(GO:0016459) |
0.0 | 0.2 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
0.0 | 1.4 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
0.0 | 0.1 | GO:0016342 | catenin complex(GO:0016342) |
0.0 | 0.2 | GO:0031528 | microvillus membrane(GO:0031528) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.9 | 6.1 | GO:0071558 | histone demethylase activity (H3-K27 specific)(GO:0071558) |
0.3 | 2.0 | GO:0000213 | tRNA-intron endonuclease activity(GO:0000213) endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892) |
0.2 | 2.6 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
0.2 | 1.2 | GO:0045322 | unmethylated CpG binding(GO:0045322) |
0.2 | 0.7 | GO:0004111 | creatine kinase activity(GO:0004111) |
0.1 | 1.0 | GO:0004614 | phosphoglucomutase activity(GO:0004614) |
0.1 | 0.9 | GO:0004972 | NMDA glutamate receptor activity(GO:0004972) |
0.1 | 0.9 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
0.1 | 0.7 | GO:0004576 | oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
0.0 | 2.8 | GO:0030507 | spectrin binding(GO:0030507) |
0.0 | 0.2 | GO:0001847 | opsonin receptor activity(GO:0001847) |
0.0 | 0.3 | GO:0004897 | ciliary neurotrophic factor receptor activity(GO:0004897) |
0.0 | 8.4 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
0.0 | 1.3 | GO:0070182 | DNA polymerase binding(GO:0070182) |
0.0 | 0.4 | GO:0003847 | 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847) |
0.0 | 1.9 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
0.0 | 0.4 | GO:0001055 | RNA polymerase II activity(GO:0001055) |
0.0 | 0.7 | GO:0042056 | chemoattractant activity(GO:0042056) |
0.0 | 0.3 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
0.0 | 0.8 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
0.0 | 0.2 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
0.0 | 0.5 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
0.0 | 0.8 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
0.0 | 1.2 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
0.0 | 0.3 | GO:0008556 | sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556) |
0.0 | 0.2 | GO:0015288 | porin activity(GO:0015288) |
0.0 | 0.3 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
0.0 | 0.1 | GO:0036470 | tyrosine 3-monooxygenase activator activity(GO:0036470) L-dopa decarboxylase activator activity(GO:0036478) |
0.0 | 0.4 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
0.0 | 0.5 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
0.0 | 0.1 | GO:0086006 | voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006) |
0.0 | 0.2 | GO:0042043 | neurexin family protein binding(GO:0042043) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 2.8 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
0.1 | 7.5 | PID_CDC42_PATHWAY | CDC42 signaling events |
0.1 | 0.8 | PID_IL5_PATHWAY | IL5-mediated signaling events |
0.0 | 1.3 | PID_BARD1_PATHWAY | BARD1 signaling events |
0.0 | 0.7 | PID_UPA_UPAR_PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
0.0 | 0.9 | PID_CD8_TCR_PATHWAY | TCR signaling in naïve CD8+ T cells |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 0.9 | REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |
0.1 | 1.6 | REACTOME_IL_7_SIGNALING | Genes involved in Interleukin-7 signaling |
0.1 | 1.3 | REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY | Genes involved in Regulation of the Fanconi anemia pathway |
0.1 | 8.6 | REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
0.1 | 1.1 | REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
0.0 | 2.8 | REACTOME_NETRIN1_SIGNALING | Genes involved in Netrin-1 signaling |
0.0 | 1.0 | REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
0.0 | 0.9 | REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
0.0 | 0.2 | REACTOME_PROLACTIN_RECEPTOR_SIGNALING | Genes involved in Prolactin receptor signaling |
0.0 | 0.3 | REACTOME_ACTIVATION_OF_RAC | Genes involved in Activation of Rac |
0.0 | 0.4 | REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
0.0 | 0.2 | REACTOME_CALNEXIN_CALRETICULIN_CYCLE | Genes involved in Calnexin/calreticulin cycle |
0.0 | 0.2 | REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
0.0 | 0.9 | REACTOME_ASPARAGINE_N_LINKED_GLYCOSYLATION | Genes involved in Asparagine N-linked glycosylation |