Motif ID: Tgif2_Tgif2lx1_Tgif2lx2
Z-value: 0.770



Transcription factors associated with Tgif2_Tgif2lx1_Tgif2lx2:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Tgif2 | ENSMUSG00000062175.7 | Tgif2 |
Tgif2lx1 | ENSMUSG00000061283.4 | Tgif2lx1 |
Tgif2lx2 | ENSMUSG00000063242.6 | Tgif2lx2 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Tgif2 | mm10_v2_chr2_+_156840077_156840141 | -0.31 | 4.6e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 3.1 | GO:1903181 | regulation of dopamine biosynthetic process(GO:1903179) positive regulation of dopamine biosynthetic process(GO:1903181) |
0.4 | 1.3 | GO:0007621 | negative regulation of female receptivity(GO:0007621) |
0.4 | 1.2 | GO:1902630 | regulation of membrane hyperpolarization(GO:1902630) |
0.3 | 0.9 | GO:0003195 | tricuspid valve formation(GO:0003195) right ventricular cardiac muscle tissue morphogenesis(GO:0003221) |
0.3 | 1.2 | GO:2000318 | positive regulation of T-helper 17 type immune response(GO:2000318) |
0.3 | 1.1 | GO:0071596 | ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596) |
0.3 | 3.0 | GO:1901621 | negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621) |
0.3 | 0.5 | GO:2000282 | regulation of cellular amino acid biosynthetic process(GO:2000282) |
0.3 | 1.0 | GO:0090472 | dibasic protein processing(GO:0090472) |
0.3 | 1.5 | GO:1902897 | regulation of postsynaptic density protein 95 clustering(GO:1902897) |
0.3 | 0.8 | GO:0045204 | MAPK export from nucleus(GO:0045204) |
0.2 | 0.7 | GO:1901052 | sarcosine metabolic process(GO:1901052) sarcosine catabolic process(GO:1901053) |
0.2 | 1.7 | GO:0033564 | anterior/posterior axon guidance(GO:0033564) |
0.2 | 1.9 | GO:0098700 | neurotransmitter loading into synaptic vesicle(GO:0098700) |
0.2 | 1.7 | GO:0090073 | positive regulation of protein homodimerization activity(GO:0090073) |
0.2 | 0.5 | GO:0021852 | pyramidal neuron migration(GO:0021852) |
0.2 | 2.8 | GO:0050901 | leukocyte tethering or rolling(GO:0050901) |
0.1 | 8.6 | GO:0030901 | midbrain development(GO:0030901) |
0.1 | 2.0 | GO:2000096 | positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096) |
0.1 | 0.7 | GO:0002317 | plasma cell differentiation(GO:0002317) |
0.1 | 0.6 | GO:0009405 | pathogenesis(GO:0009405) |
0.1 | 0.3 | GO:0048239 | negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695) |
0.1 | 1.0 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
0.1 | 0.4 | GO:0015825 | L-serine transport(GO:0015825) |
0.1 | 0.8 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
0.1 | 0.3 | GO:2001187 | natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187) |
0.1 | 0.4 | GO:0042701 | progesterone secretion(GO:0042701) |
0.1 | 2.2 | GO:0071108 | protein K48-linked deubiquitination(GO:0071108) |
0.1 | 2.7 | GO:0006904 | vesicle docking involved in exocytosis(GO:0006904) |
0.1 | 0.4 | GO:0071955 | recycling endosome to Golgi transport(GO:0071955) |
0.1 | 1.3 | GO:2001014 | regulation of skeletal muscle cell differentiation(GO:2001014) |
0.1 | 2.1 | GO:0071625 | vocalization behavior(GO:0071625) |
0.1 | 0.2 | GO:0042796 | snRNA transcription from RNA polymerase III promoter(GO:0042796) |
0.1 | 0.2 | GO:0006030 | chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032) |
0.1 | 0.4 | GO:0005981 | regulation of glycogen catabolic process(GO:0005981) |
0.1 | 1.3 | GO:0048268 | clathrin coat assembly(GO:0048268) |
0.1 | 0.3 | GO:1902951 | negative regulation of dendritic spine maintenance(GO:1902951) |
0.1 | 0.4 | GO:0046415 | urate metabolic process(GO:0046415) |
0.0 | 0.1 | GO:0097051 | establishment of protein localization to endoplasmic reticulum membrane(GO:0097051) |
0.0 | 0.6 | GO:0072600 | establishment of protein localization to Golgi(GO:0072600) |
0.0 | 0.8 | GO:2000251 | positive regulation of actin cytoskeleton reorganization(GO:2000251) |
0.0 | 0.9 | GO:0045956 | positive regulation of calcium ion-dependent exocytosis(GO:0045956) |
0.0 | 0.1 | GO:0090370 | negative regulation of cholesterol efflux(GO:0090370) |
0.0 | 1.2 | GO:0071480 | cellular response to gamma radiation(GO:0071480) |
0.0 | 1.3 | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I(GO:0002474) |
0.0 | 0.1 | GO:1900368 | regulation of RNA interference(GO:1900368) |
0.0 | 1.3 | GO:0048246 | macrophage chemotaxis(GO:0048246) |
0.0 | 0.4 | GO:0018230 | peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231) |
0.0 | 0.8 | GO:0031365 | N-terminal protein amino acid modification(GO:0031365) |
0.0 | 0.7 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
0.0 | 0.2 | GO:0045836 | positive regulation of meiotic nuclear division(GO:0045836) |
0.0 | 0.8 | GO:0008089 | anterograde axonal transport(GO:0008089) |
0.0 | 0.2 | GO:0070995 | NADPH oxidation(GO:0070995) |
0.0 | 0.1 | GO:0015744 | succinate transport(GO:0015744) |
0.0 | 0.7 | GO:0006376 | mRNA splice site selection(GO:0006376) |
0.0 | 1.2 | GO:0042475 | odontogenesis of dentin-containing tooth(GO:0042475) |
0.0 | 0.4 | GO:0071470 | cellular response to osmotic stress(GO:0071470) |
0.0 | 0.1 | GO:0008300 | isoprenoid catabolic process(GO:0008300) |
0.0 | 0.0 | GO:2000501 | natural killer cell chemotaxis(GO:0035747) regulation of natural killer cell chemotaxis(GO:2000501) |
0.0 | 0.4 | GO:0003333 | amino acid transmembrane transport(GO:0003333) |
0.0 | 0.1 | GO:0042407 | cristae formation(GO:0042407) |
0.0 | 0.1 | GO:0042538 | hyperosmotic salinity response(GO:0042538) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 2.1 | GO:0097513 | myosin II filament(GO:0097513) |
0.2 | 3.0 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
0.2 | 0.9 | GO:0030121 | AP-1 adaptor complex(GO:0030121) |
0.1 | 1.7 | GO:0031464 | Cul4A-RING E3 ubiquitin ligase complex(GO:0031464) |
0.1 | 0.6 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
0.1 | 1.0 | GO:0012510 | trans-Golgi network transport vesicle membrane(GO:0012510) |
0.1 | 2.1 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
0.1 | 1.6 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
0.1 | 0.9 | GO:0031045 | dense core granule(GO:0031045) |
0.0 | 0.1 | GO:0031074 | nucleocytoplasmic shuttling complex(GO:0031074) |
0.0 | 0.9 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
0.0 | 1.8 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
0.0 | 2.0 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
0.0 | 2.7 | GO:0030667 | secretory granule membrane(GO:0030667) |
0.0 | 0.4 | GO:0042587 | glycogen granule(GO:0042587) |
0.0 | 0.3 | GO:0000783 | telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783) |
0.0 | 0.5 | GO:0097228 | sperm principal piece(GO:0097228) |
0.0 | 0.4 | GO:0030008 | TRAPP complex(GO:0030008) |
0.0 | 11.1 | GO:0005667 | transcription factor complex(GO:0005667) |
0.0 | 0.1 | GO:0098536 | deuterosome(GO:0098536) |
0.0 | 1.3 | GO:0005871 | kinesin complex(GO:0005871) |
0.0 | 0.1 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
0.0 | 0.3 | GO:0042101 | T cell receptor complex(GO:0042101) |
0.0 | 0.4 | GO:0030660 | Golgi-associated vesicle membrane(GO:0030660) |
0.0 | 0.2 | GO:0030061 | mitochondrial crista(GO:0030061) |
0.0 | 0.2 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
0.0 | 1.5 | GO:0043198 | dendritic shaft(GO:0043198) |
0.0 | 0.0 | GO:0009328 | phenylalanine-tRNA ligase complex(GO:0009328) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 1.3 | GO:0031752 | D3 dopamine receptor binding(GO:0031750) D5 dopamine receptor binding(GO:0031752) |
0.3 | 3.0 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
0.3 | 1.7 | GO:0005042 | netrin receptor activity(GO:0005042) |
0.3 | 0.8 | GO:0010698 | acetyltransferase activator activity(GO:0010698) |
0.2 | 3.1 | GO:0050897 | cobalt ion binding(GO:0050897) |
0.2 | 0.7 | GO:0046997 | sarcosine dehydrogenase activity(GO:0008480) oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor(GO:0046997) |
0.2 | 1.1 | GO:0070728 | leucine binding(GO:0070728) |
0.2 | 0.7 | GO:0030292 | protein tyrosine kinase inhibitor activity(GO:0030292) |
0.2 | 0.8 | GO:0015440 | peptide-transporting ATPase activity(GO:0015440) |
0.2 | 1.3 | GO:0032051 | clathrin light chain binding(GO:0032051) |
0.1 | 2.1 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
0.1 | 1.2 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
0.1 | 0.4 | GO:0015143 | urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702) |
0.1 | 1.9 | GO:0005313 | L-glutamate transmembrane transporter activity(GO:0005313) |
0.1 | 1.0 | GO:0048406 | nerve growth factor binding(GO:0048406) |
0.1 | 0.7 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
0.1 | 0.1 | GO:0015172 | acidic amino acid transmembrane transporter activity(GO:0015172) |
0.1 | 0.3 | GO:0042610 | CD8 receptor binding(GO:0042610) |
0.1 | 1.3 | GO:0042605 | peptide antigen binding(GO:0042605) |
0.1 | 1.4 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
0.1 | 0.2 | GO:0004568 | chitinase activity(GO:0004568) |
0.1 | 0.4 | GO:0015180 | L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858) |
0.1 | 1.2 | GO:0035613 | RNA stem-loop binding(GO:0035613) |
0.1 | 0.6 | GO:0015643 | toxic substance binding(GO:0015643) |
0.0 | 0.2 | GO:0016151 | nickel cation binding(GO:0016151) |
0.0 | 0.3 | GO:0010521 | telomerase inhibitor activity(GO:0010521) |
0.0 | 0.3 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
0.0 | 0.5 | GO:0030346 | protein phosphatase 2B binding(GO:0030346) |
0.0 | 2.2 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
0.0 | 0.9 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
0.0 | 0.7 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
0.0 | 0.2 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
0.0 | 0.2 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
0.0 | 0.1 | GO:0070883 | pre-miRNA binding(GO:0070883) |
0.0 | 0.1 | GO:0060072 | large conductance calcium-activated potassium channel activity(GO:0060072) |
0.0 | 0.6 | GO:0008009 | chemokine activity(GO:0008009) |
0.0 | 0.9 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
0.0 | 0.1 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
0.0 | 0.8 | GO:0050840 | extracellular matrix binding(GO:0050840) |
0.0 | 0.5 | GO:0004364 | glutathione transferase activity(GO:0004364) |
0.0 | 0.1 | GO:0001162 | RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162) |
0.0 | 0.7 | GO:0036002 | pre-mRNA binding(GO:0036002) |
0.0 | 1.5 | GO:0030165 | PDZ domain binding(GO:0030165) |
0.0 | 0.8 | GO:0008276 | protein methyltransferase activity(GO:0008276) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 3.1 | PID_HIF2PATHWAY | HIF-2-alpha transcription factor network |
0.1 | 2.5 | PID_IL3_PATHWAY | IL3-mediated signaling events |
0.0 | 1.6 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
0.0 | 1.3 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
0.0 | 0.8 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
0.0 | 1.0 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
0.0 | 1.2 | PID_AP1_PATHWAY | AP-1 transcription factor network |
0.0 | 0.7 | PID_BCR_5PATHWAY | BCR signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 3.1 | REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
0.1 | 3.0 | REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB | Genes involved in PKA-mediated phosphorylation of CREB |
0.1 | 1.7 | REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
0.1 | 1.0 | REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
0.1 | 2.1 | REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
0.0 | 1.4 | REACTOME_DARPP_32_EVENTS | Genes involved in DARPP-32 events |
0.0 | 2.3 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
0.0 | 0.4 | REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
0.0 | 1.3 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
0.0 | 0.3 | REACTOME_CD28_DEPENDENT_VAV1_PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
0.0 | 0.3 | REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
0.0 | 0.1 | REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
0.0 | 0.1 | REACTOME_MICRORNA_MIRNA_BIOGENESIS | Genes involved in MicroRNA (miRNA) Biogenesis |
0.0 | 0.4 | REACTOME_ENOS_ACTIVATION_AND_REGULATION | Genes involved in eNOS activation and regulation |
0.0 | 0.5 | REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
0.0 | 0.1 | REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |