Motif ID: Nfatc3
Z-value: 1.183

Transcription factors associated with Nfatc3:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Nfatc3 | ENSMUSG00000031902.9 | Nfatc3 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Nfatc3 | mm10_v2_chr8_+_106059562_106059623 | -0.28 | 7.2e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.1 | 3.3 | GO:0060854 | patterning of lymph vessels(GO:0060854) |
0.8 | 3.3 | GO:0060745 | mammary gland branching involved in pregnancy(GO:0060745) |
0.8 | 4.9 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
0.7 | 5.0 | GO:2001199 | negative regulation of dendritic cell differentiation(GO:2001199) |
0.6 | 1.7 | GO:0002302 | CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302) |
0.5 | 2.6 | GO:0003406 | retinal pigment epithelium development(GO:0003406) |
0.5 | 1.5 | GO:1902256 | apoptotic process involved in outflow tract morphogenesis(GO:0003275) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256) response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869) |
0.5 | 2.4 | GO:0060849 | regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849) |
0.5 | 1.4 | GO:1903903 | striated muscle atrophy(GO:0014891) positive regulation of keratinocyte apoptotic process(GO:1902174) regulation of establishment of T cell polarity(GO:1903903) |
0.5 | 1.8 | GO:2000319 | negative regulation of T-helper 17 type immune response(GO:2000317) regulation of T-helper 17 cell differentiation(GO:2000319) negative regulation of T-helper 17 cell differentiation(GO:2000320) |
0.4 | 1.1 | GO:0031117 | positive regulation of microtubule depolymerization(GO:0031117) |
0.4 | 1.1 | GO:0032918 | polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918) |
0.3 | 1.3 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) |
0.3 | 1.3 | GO:0010749 | regulation of nitric oxide mediated signal transduction(GO:0010749) |
0.3 | 2.8 | GO:1990845 | adaptive thermogenesis(GO:1990845) |
0.3 | 0.9 | GO:1903976 | negative regulation of glial cell migration(GO:1903976) |
0.3 | 3.8 | GO:0046643 | regulation of gamma-delta T cell differentiation(GO:0045586) regulation of gamma-delta T cell activation(GO:0046643) |
0.3 | 1.4 | GO:0045163 | clustering of voltage-gated potassium channels(GO:0045163) |
0.3 | 0.8 | GO:0033092 | positive regulation of immature T cell proliferation in thymus(GO:0033092) |
0.2 | 1.2 | GO:0019659 | fermentation(GO:0006113) lactate biosynthetic process from pyruvate(GO:0019244) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661) |
0.2 | 1.3 | GO:0042699 | follicle-stimulating hormone signaling pathway(GO:0042699) |
0.2 | 0.8 | GO:2000182 | regulation of progesterone biosynthetic process(GO:2000182) |
0.2 | 0.5 | GO:0003032 | detection of oxygen(GO:0003032) negative regulation of macrophage cytokine production(GO:0010936) |
0.2 | 0.7 | GO:0044330 | canonical Wnt signaling pathway involved in positive regulation of wound healing(GO:0044330) lactic acid secretion(GO:0046722) regulation of metanephric cap mesenchymal cell proliferation(GO:0090095) positive regulation of metanephric cap mesenchymal cell proliferation(GO:0090096) |
0.2 | 1.1 | GO:1901552 | positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142) |
0.2 | 0.7 | GO:0007412 | axon target recognition(GO:0007412) |
0.2 | 1.2 | GO:0051461 | protein import into peroxisome matrix, docking(GO:0016560) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461) |
0.2 | 1.0 | GO:0006363 | termination of RNA polymerase I transcription(GO:0006363) |
0.2 | 3.1 | GO:0032060 | bleb assembly(GO:0032060) |
0.1 | 0.4 | GO:0072554 | arterial endothelial cell fate commitment(GO:0060844) blood vessel endothelial cell fate commitment(GO:0060846) endothelial cell fate specification(GO:0060847) Notch signaling pathway involved in arterial endothelial cell fate commitment(GO:0060853) blood vessel lumenization(GO:0072554) blood vessel endothelial cell fate specification(GO:0097101) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) positive regulation of heart induction(GO:1901321) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066) |
0.1 | 0.6 | GO:0030091 | protein repair(GO:0030091) |
0.1 | 0.4 | GO:0003278 | apoptotic process involved in heart morphogenesis(GO:0003278) |
0.1 | 0.6 | GO:0035021 | negative regulation of Rac protein signal transduction(GO:0035021) |
0.1 | 0.4 | GO:1902220 | positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902220) |
0.1 | 1.4 | GO:0002536 | respiratory burst involved in inflammatory response(GO:0002536) negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665) |
0.1 | 1.0 | GO:0043569 | negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569) |
0.1 | 0.8 | GO:1901837 | negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837) |
0.1 | 0.8 | GO:0048739 | cardiac muscle fiber development(GO:0048739) |
0.1 | 0.7 | GO:0045578 | negative regulation of B cell differentiation(GO:0045578) |
0.1 | 0.6 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
0.1 | 0.6 | GO:0036438 | maintenance of lens transparency(GO:0036438) |
0.1 | 0.5 | GO:0010626 | negative regulation of Schwann cell proliferation(GO:0010626) |
0.1 | 0.3 | GO:1903538 | meiotic cell cycle process involved in oocyte maturation(GO:1903537) regulation of meiotic cell cycle process involved in oocyte maturation(GO:1903538) |
0.1 | 2.3 | GO:0060579 | ventral spinal cord interneuron fate commitment(GO:0060579) cell fate commitment involved in pattern specification(GO:0060581) |
0.1 | 0.4 | GO:1903936 | response to diamide(GO:0072737) cellular response to diamide(GO:0072738) cellular response to sodium arsenite(GO:1903936) |
0.1 | 0.4 | GO:1903031 | regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033) |
0.1 | 0.3 | GO:0016554 | cytidine to uridine editing(GO:0016554) |
0.1 | 0.2 | GO:0007290 | spermatid nucleus elongation(GO:0007290) |
0.1 | 0.5 | GO:0040032 | post-embryonic body morphogenesis(GO:0040032) |
0.1 | 0.3 | GO:1902527 | positive regulation of protein monoubiquitination(GO:1902527) |
0.1 | 0.3 | GO:0070543 | response to linoleic acid(GO:0070543) |
0.1 | 0.9 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
0.1 | 1.6 | GO:0051451 | myoblast migration(GO:0051451) |
0.1 | 1.1 | GO:0046485 | ether lipid metabolic process(GO:0046485) |
0.1 | 0.8 | GO:0043568 | positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568) |
0.1 | 0.3 | GO:0048539 | bone marrow development(GO:0048539) |
0.1 | 0.5 | GO:1901164 | negative regulation of trophoblast cell migration(GO:1901164) |
0.1 | 0.3 | GO:0030043 | actin filament fragmentation(GO:0030043) |
0.1 | 0.4 | GO:0002121 | inter-male aggressive behavior(GO:0002121) |
0.1 | 0.7 | GO:0048102 | autophagic cell death(GO:0048102) |
0.1 | 0.1 | GO:0045168 | cell-cell signaling involved in cell fate commitment(GO:0045168) |
0.1 | 0.4 | GO:0035063 | nuclear speck organization(GO:0035063) |
0.1 | 1.2 | GO:0060159 | regulation of dopamine receptor signaling pathway(GO:0060159) |
0.1 | 0.3 | GO:0042905 | 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
0.1 | 1.1 | GO:0022027 | interkinetic nuclear migration(GO:0022027) |
0.1 | 1.2 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
0.1 | 0.2 | GO:0042823 | pyridoxal phosphate biosynthetic process(GO:0042823) |
0.1 | 1.0 | GO:0099628 | receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628) |
0.1 | 0.3 | GO:1901301 | regulation of cargo loading into COPII-coated vesicle(GO:1901301) |
0.1 | 0.4 | GO:0002922 | positive regulation of humoral immune response(GO:0002922) progesterone receptor signaling pathway(GO:0050847) |
0.1 | 1.0 | GO:0043402 | glucocorticoid mediated signaling pathway(GO:0043402) |
0.1 | 0.4 | GO:0043137 | DNA replication, removal of RNA primer(GO:0043137) |
0.1 | 0.2 | GO:0003345 | proepicardium cell migration involved in pericardium morphogenesis(GO:0003345) |
0.1 | 0.6 | GO:0006027 | glycosaminoglycan catabolic process(GO:0006027) |
0.1 | 0.3 | GO:1902626 | assembly of large subunit precursor of preribosome(GO:1902626) |
0.1 | 0.2 | GO:2000297 | negative regulation of synapse maturation(GO:2000297) |
0.1 | 0.7 | GO:0043586 | tongue development(GO:0043586) |
0.1 | 0.4 | GO:0070836 | caveola assembly(GO:0070836) |
0.1 | 0.4 | GO:1904217 | regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) regulation of serine C-palmitoyltransferase activity(GO:1904220) positive regulation of serine C-palmitoyltransferase activity(GO:1904222) |
0.1 | 0.9 | GO:0044406 | adhesion of symbiont to host(GO:0044406) |
0.1 | 0.7 | GO:0051574 | positive regulation of histone H3-K9 methylation(GO:0051574) |
0.1 | 0.4 | GO:0019254 | carnitine metabolic process, CoA-linked(GO:0019254) |
0.1 | 0.5 | GO:0043922 | negative regulation by host of viral transcription(GO:0043922) |
0.0 | 0.2 | GO:0071638 | negative regulation of monocyte chemotactic protein-1 production(GO:0071638) |
0.0 | 0.4 | GO:2000491 | positive regulation of hepatic stellate cell activation(GO:2000491) |
0.0 | 0.3 | GO:0030579 | ubiquitin-dependent SMAD protein catabolic process(GO:0030579) |
0.0 | 0.6 | GO:0060394 | negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394) |
0.0 | 0.2 | GO:0060591 | chondroblast differentiation(GO:0060591) |
0.0 | 0.1 | GO:0071918 | urea transmembrane transport(GO:0071918) |
0.0 | 0.7 | GO:2000353 | positive regulation of endothelial cell apoptotic process(GO:2000353) |
0.0 | 0.3 | GO:1903003 | positive regulation of protein deubiquitination(GO:1903003) |
0.0 | 0.4 | GO:0035520 | monoubiquitinated protein deubiquitination(GO:0035520) |
0.0 | 0.1 | GO:0090400 | stress-induced premature senescence(GO:0090400) |
0.0 | 0.4 | GO:1904263 | positive regulation of TORC1 signaling(GO:1904263) |
0.0 | 0.4 | GO:0010566 | regulation of ketone biosynthetic process(GO:0010566) |
0.0 | 0.4 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
0.0 | 0.1 | GO:0009838 | abscission(GO:0009838) |
0.0 | 0.2 | GO:0007256 | activation of JNKK activity(GO:0007256) |
0.0 | 0.4 | GO:2000580 | positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582) |
0.0 | 0.8 | GO:0040015 | negative regulation of multicellular organism growth(GO:0040015) |
0.0 | 1.4 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
0.0 | 0.2 | GO:0090091 | positive regulation of extracellular matrix disassembly(GO:0090091) |
0.0 | 0.2 | GO:0006621 | protein retention in ER lumen(GO:0006621) |
0.0 | 0.3 | GO:0000963 | mitochondrial RNA processing(GO:0000963) |
0.0 | 0.2 | GO:0019348 | dolichol metabolic process(GO:0019348) |
0.0 | 0.7 | GO:0060009 | Sertoli cell development(GO:0060009) |
0.0 | 0.4 | GO:0010447 | response to acidic pH(GO:0010447) |
0.0 | 0.4 | GO:0032000 | positive regulation of fatty acid beta-oxidation(GO:0032000) |
0.0 | 0.8 | GO:0010172 | embryonic body morphogenesis(GO:0010172) |
0.0 | 0.5 | GO:0050892 | intestinal absorption(GO:0050892) |
0.0 | 0.6 | GO:0070536 | protein K63-linked deubiquitination(GO:0070536) |
0.0 | 0.1 | GO:0010724 | regulation of definitive erythrocyte differentiation(GO:0010724) |
0.0 | 0.9 | GO:0050819 | negative regulation of coagulation(GO:0050819) |
0.0 | 0.4 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
0.0 | 0.7 | GO:0021904 | dorsal/ventral neural tube patterning(GO:0021904) |
0.0 | 0.1 | GO:0006083 | acetate metabolic process(GO:0006083) |
0.0 | 0.1 | GO:0097298 | regulation of nucleus size(GO:0097298) |
0.0 | 0.8 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
0.0 | 0.3 | GO:0006415 | translational termination(GO:0006415) |
0.0 | 0.1 | GO:0014889 | muscle atrophy(GO:0014889) |
0.0 | 0.1 | GO:1904751 | positive regulation of protein localization to nucleolus(GO:1904751) |
0.0 | 0.7 | GO:0045214 | sarcomere organization(GO:0045214) |
0.0 | 0.4 | GO:0045063 | T-helper 1 cell differentiation(GO:0045063) |
0.0 | 0.8 | GO:0060325 | face morphogenesis(GO:0060325) |
0.0 | 2.8 | GO:0051028 | mRNA transport(GO:0051028) |
0.0 | 0.3 | GO:0030575 | nuclear body organization(GO:0030575) |
0.0 | 0.2 | GO:0005513 | detection of calcium ion(GO:0005513) |
0.0 | 0.2 | GO:2001256 | regulation of store-operated calcium entry(GO:2001256) |
0.0 | 0.1 | GO:0006742 | NADP catabolic process(GO:0006742) pyridine nucleotide catabolic process(GO:0019364) |
0.0 | 0.6 | GO:0015804 | neutral amino acid transport(GO:0015804) |
0.0 | 0.2 | GO:0097119 | postsynaptic density protein 95 clustering(GO:0097119) |
0.0 | 0.3 | GO:0051894 | positive regulation of focal adhesion assembly(GO:0051894) |
0.0 | 1.3 | GO:0032024 | positive regulation of insulin secretion(GO:0032024) |
0.0 | 0.2 | GO:2001214 | positive regulation of vasculogenesis(GO:2001214) |
0.0 | 0.1 | GO:0019087 | transformation of host cell by virus(GO:0019087) |
0.0 | 0.4 | GO:0010758 | regulation of macrophage chemotaxis(GO:0010758) |
0.0 | 0.4 | GO:0045116 | protein neddylation(GO:0045116) |
0.0 | 0.0 | GO:0006662 | glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904) |
0.0 | 0.1 | GO:0072318 | clathrin coat disassembly(GO:0072318) |
0.0 | 0.7 | GO:0030500 | regulation of bone mineralization(GO:0030500) |
0.0 | 0.4 | GO:0030488 | tRNA methylation(GO:0030488) |
0.0 | 0.4 | GO:0003016 | respiratory system process(GO:0003016) |
0.0 | 0.4 | GO:0097120 | receptor localization to synapse(GO:0097120) |
0.0 | 1.0 | GO:0072164 | ureteric bud development(GO:0001657) mesonephric epithelium development(GO:0072163) mesonephric tubule development(GO:0072164) |
0.0 | 0.2 | GO:0030212 | hyaluronan metabolic process(GO:0030212) |
0.0 | 0.3 | GO:0046470 | phosphatidylcholine metabolic process(GO:0046470) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 3.3 | GO:0097550 | transcriptional preinitiation complex(GO:0097550) |
0.3 | 1.2 | GO:0017071 | intracellular cyclic nucleotide activated cation channel complex(GO:0017071) |
0.2 | 1.6 | GO:0036195 | muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195) |
0.2 | 1.0 | GO:0090498 | extrinsic component of Golgi membrane(GO:0090498) |
0.2 | 0.7 | GO:0032021 | NELF complex(GO:0032021) |
0.2 | 0.5 | GO:0031417 | NatC complex(GO:0031417) |
0.2 | 1.4 | GO:0030478 | actin cap(GO:0030478) |
0.1 | 0.6 | GO:0042719 | mitochondrial intermembrane space protein transporter complex(GO:0042719) |
0.1 | 3.1 | GO:0043218 | compact myelin(GO:0043218) |
0.1 | 2.3 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
0.1 | 1.4 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
0.1 | 0.8 | GO:0031315 | extrinsic component of mitochondrial outer membrane(GO:0031315) |
0.1 | 0.4 | GO:1990131 | Iml1 complex(GO:1990130) Gtr1-Gtr2 GTPase complex(GO:1990131) |
0.1 | 0.4 | GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex(GO:0002193) |
0.1 | 1.2 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
0.1 | 1.3 | GO:0031143 | pseudopodium(GO:0031143) |
0.1 | 0.2 | GO:0031466 | Cul5-RING ubiquitin ligase complex(GO:0031466) |
0.1 | 0.9 | GO:0020005 | symbiont-containing vacuole membrane(GO:0020005) |
0.1 | 0.4 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
0.1 | 0.7 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
0.1 | 1.7 | GO:0000242 | pericentriolar material(GO:0000242) |
0.1 | 1.0 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
0.1 | 0.7 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
0.1 | 0.6 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
0.0 | 0.4 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
0.0 | 0.6 | GO:0030127 | COPII vesicle coat(GO:0030127) |
0.0 | 0.3 | GO:0042382 | paraspeckles(GO:0042382) |
0.0 | 2.2 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
0.0 | 1.3 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
0.0 | 1.4 | GO:0005719 | nuclear euchromatin(GO:0005719) |
0.0 | 1.4 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
0.0 | 1.1 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
0.0 | 0.4 | GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506) |
0.0 | 0.8 | GO:0060077 | inhibitory synapse(GO:0060077) |
0.0 | 0.5 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
0.0 | 0.2 | GO:0031012 | extracellular matrix(GO:0031012) |
0.0 | 0.1 | GO:0031982 | vesicle(GO:0031982) |
0.0 | 0.3 | GO:0044292 | dendrite terminus(GO:0044292) |
0.0 | 0.8 | GO:0032420 | stereocilium(GO:0032420) |
0.0 | 0.7 | GO:0031941 | filamentous actin(GO:0031941) |
0.0 | 0.4 | GO:0001741 | XY body(GO:0001741) |
0.0 | 0.8 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
0.0 | 0.1 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
0.0 | 0.5 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
0.0 | 0.1 | GO:0090543 | Flemming body(GO:0090543) |
0.0 | 0.2 | GO:0032587 | ruffle membrane(GO:0032587) |
0.0 | 0.3 | GO:0005581 | collagen trimer(GO:0005581) |
0.0 | 0.4 | GO:0035371 | microtubule plus-end(GO:0035371) |
0.0 | 0.5 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
0.0 | 0.8 | GO:0005643 | nuclear pore(GO:0005643) |
0.0 | 0.4 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
0.0 | 1.0 | GO:0001669 | acrosomal vesicle(GO:0001669) |
0.0 | 2.0 | GO:0043209 | myelin sheath(GO:0043209) |
0.0 | 0.3 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
0.0 | 0.3 | GO:0055038 | recycling endosome membrane(GO:0055038) |
0.0 | 3.8 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
0.0 | 0.2 | GO:0005685 | U1 snRNP(GO:0005685) |
0.0 | 0.6 | GO:0000792 | heterochromatin(GO:0000792) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.1 | 3.3 | GO:0001225 | RNA polymerase II transcription coactivator binding(GO:0001225) |
1.1 | 3.3 | GO:0031798 | type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052) |
0.7 | 2.8 | GO:0017077 | oxidative phosphorylation uncoupler activity(GO:0017077) |
0.5 | 2.0 | GO:0008142 | oxysterol binding(GO:0008142) |
0.4 | 1.3 | GO:0031896 | V2 vasopressin receptor binding(GO:0031896) |
0.4 | 1.8 | GO:0042610 | CD8 receptor binding(GO:0042610) |
0.4 | 1.1 | GO:0004145 | diamine N-acetyltransferase activity(GO:0004145) |
0.3 | 1.6 | GO:0005134 | interleukin-2 receptor binding(GO:0005134) |
0.3 | 1.2 | GO:0004459 | L-lactate dehydrogenase activity(GO:0004459) |
0.3 | 1.3 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
0.2 | 1.2 | GO:0005052 | peroxisome matrix targeting signal-1 binding(GO:0005052) |
0.2 | 0.6 | GO:0008109 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109) |
0.2 | 2.6 | GO:0003708 | retinoic acid receptor activity(GO:0003708) |
0.2 | 2.4 | GO:0001972 | retinoic acid binding(GO:0001972) |
0.2 | 0.7 | GO:0031694 | alpha-2A adrenergic receptor binding(GO:0031694) |
0.2 | 0.7 | GO:0004096 | catalase activity(GO:0004096) |
0.2 | 1.1 | GO:0016714 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714) |
0.1 | 0.5 | GO:0034714 | type III transforming growth factor beta receptor binding(GO:0034714) |
0.1 | 1.4 | GO:0008379 | thioredoxin peroxidase activity(GO:0008379) |
0.1 | 0.8 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
0.1 | 1.0 | GO:0043423 | 3-phosphoinositide-dependent protein kinase binding(GO:0043423) |
0.1 | 1.0 | GO:0031811 | G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812) |
0.1 | 0.4 | GO:0031871 | proteinase activated receptor binding(GO:0031871) |
0.1 | 0.5 | GO:0004784 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
0.1 | 1.5 | GO:0008301 | DNA binding, bending(GO:0008301) |
0.1 | 0.4 | GO:0071987 | WD40-repeat domain binding(GO:0071987) |
0.1 | 0.6 | GO:0033743 | peptide-methionine (R)-S-oxide reductase activity(GO:0033743) |
0.1 | 0.3 | GO:0004769 | steroid delta-isomerase activity(GO:0004769) |
0.1 | 0.3 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
0.1 | 0.4 | GO:0004741 | [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741) |
0.1 | 0.4 | GO:0004466 | long-chain-acyl-CoA dehydrogenase activity(GO:0004466) |
0.1 | 0.4 | GO:0008269 | JAK pathway signal transduction adaptor activity(GO:0008269) |
0.1 | 0.5 | GO:0051429 | corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430) |
0.1 | 0.3 | GO:0004126 | cytidine deaminase activity(GO:0004126) |
0.1 | 0.3 | GO:0003998 | acylphosphatase activity(GO:0003998) |
0.1 | 0.5 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
0.1 | 0.9 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
0.1 | 0.6 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
0.1 | 1.0 | GO:0001054 | RNA polymerase I activity(GO:0001054) |
0.1 | 1.7 | GO:0008432 | JUN kinase binding(GO:0008432) |
0.1 | 2.2 | GO:0008307 | structural constituent of muscle(GO:0008307) |
0.1 | 0.6 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
0.1 | 0.4 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
0.1 | 0.2 | GO:0004706 | JUN kinase kinase kinase activity(GO:0004706) |
0.1 | 2.1 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
0.1 | 0.2 | GO:0046923 | ER retention sequence binding(GO:0046923) |
0.1 | 1.5 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
0.1 | 2.1 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
0.1 | 0.2 | GO:0003976 | UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976) |
0.1 | 2.0 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
0.1 | 0.6 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
0.1 | 1.6 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
0.1 | 0.3 | GO:0001758 | retinal dehydrogenase activity(GO:0001758) |
0.1 | 0.7 | GO:0005314 | high-affinity glutamate transmembrane transporter activity(GO:0005314) |
0.0 | 0.4 | GO:0009019 | tRNA (guanine-N1-)-methyltransferase activity(GO:0009019) |
0.0 | 0.9 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
0.0 | 0.6 | GO:0016505 | peptidase activator activity involved in apoptotic process(GO:0016505) |
0.0 | 0.7 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
0.0 | 0.3 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
0.0 | 0.3 | GO:0048495 | Roundabout binding(GO:0048495) |
0.0 | 0.2 | GO:0051525 | NFAT protein binding(GO:0051525) |
0.0 | 0.2 | GO:0035614 | snRNA stem-loop binding(GO:0035614) |
0.0 | 0.2 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
0.0 | 0.0 | GO:0097016 | L27 domain binding(GO:0097016) |
0.0 | 0.7 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
0.0 | 0.6 | GO:0005328 | neurotransmitter:sodium symporter activity(GO:0005328) |
0.0 | 0.4 | GO:0017176 | phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176) |
0.0 | 0.2 | GO:0004887 | thyroid hormone receptor activity(GO:0004887) |
0.0 | 0.4 | GO:0034713 | type I transforming growth factor beta receptor binding(GO:0034713) |
0.0 | 0.3 | GO:0003747 | translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079) |
0.0 | 0.1 | GO:0003836 | beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836) |
0.0 | 0.7 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
0.0 | 0.2 | GO:0036122 | BMP binding(GO:0036122) |
0.0 | 0.2 | GO:0031802 | type 5 metabotropic glutamate receptor binding(GO:0031802) |
0.0 | 1.8 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
0.0 | 0.4 | GO:0070403 | NAD+ binding(GO:0070403) |
0.0 | 0.3 | GO:0004622 | lysophospholipase activity(GO:0004622) |
0.0 | 0.4 | GO:0022889 | L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889) |
0.0 | 0.1 | GO:0003987 | acetate-CoA ligase activity(GO:0003987) |
0.0 | 0.8 | GO:0070182 | DNA polymerase binding(GO:0070182) |
0.0 | 0.1 | GO:0001179 | RNA polymerase I transcription factor binding(GO:0001179) inward rectifier potassium channel inhibitor activity(GO:0070320) |
0.0 | 1.1 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
0.0 | 0.1 | GO:0001537 | N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537) |
0.0 | 0.7 | GO:0043394 | proteoglycan binding(GO:0043394) |
0.0 | 0.9 | GO:0070888 | E-box binding(GO:0070888) |
0.0 | 0.3 | GO:0034450 | ubiquitin-ubiquitin ligase activity(GO:0034450) |
0.0 | 1.4 | GO:0017022 | myosin binding(GO:0017022) |
0.0 | 0.3 | GO:0035612 | AP-2 adaptor complex binding(GO:0035612) |
0.0 | 0.9 | GO:0032452 | histone demethylase activity(GO:0032452) |
0.0 | 0.1 | GO:0035243 | protein-arginine omega-N symmetric methyltransferase activity(GO:0035243) |
0.0 | 0.1 | GO:0017150 | tRNA dihydrouridine synthase activity(GO:0017150) |
0.0 | 0.1 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
0.0 | 0.1 | GO:0034046 | poly(G) binding(GO:0034046) |
0.0 | 0.2 | GO:0010181 | FMN binding(GO:0010181) |
0.0 | 0.2 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
0.0 | 0.3 | GO:0070300 | phosphatidic acid binding(GO:0070300) |
0.0 | 0.4 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
0.0 | 0.2 | GO:0045499 | chemorepellent activity(GO:0045499) |
0.0 | 0.3 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
0.0 | 1.1 | GO:0035257 | nuclear hormone receptor binding(GO:0035257) |
0.0 | 0.2 | GO:0070412 | R-SMAD binding(GO:0070412) |
0.0 | 1.1 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
0.0 | 0.9 | GO:0004872 | receptor activity(GO:0004872) molecular transducer activity(GO:0060089) |
0.0 | 0.1 | GO:0004768 | stearoyl-CoA 9-desaturase activity(GO:0004768) |
0.0 | 0.4 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
0.0 | 1.0 | GO:0035326 | enhancer binding(GO:0035326) |
0.0 | 0.4 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
0.0 | 0.7 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
0.0 | 0.2 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
0.0 | 0.4 | GO:0050840 | extracellular matrix binding(GO:0050840) |
0.0 | 2.1 | GO:0030246 | carbohydrate binding(GO:0030246) |
0.0 | 0.9 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
0.0 | 0.6 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 5.3 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
0.1 | 4.0 | PID_FOXM1_PATHWAY | FOXM1 transcription factor network |
0.1 | 2.4 | PID_INTEGRIN_A9B1_PATHWAY | Alpha9 beta1 integrin signaling events |
0.1 | 2.3 | PID_GLYPICAN_1PATHWAY | Glypican 1 network |
0.1 | 1.6 | PID_IL27_PATHWAY | IL27-mediated signaling events |
0.1 | 0.8 | PID_INTEGRIN2_PATHWAY | Beta2 integrin cell surface interactions |
0.1 | 2.5 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
0.1 | 3.1 | PID_A6B1_A6B4_INTEGRIN_PATHWAY | a6b1 and a6b4 Integrin signaling |
0.1 | 2.8 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
0.1 | 1.1 | PID_S1P_S1P2_PATHWAY | S1P2 pathway |
0.0 | 1.4 | PID_AVB3_OPN_PATHWAY | Osteopontin-mediated events |
0.0 | 1.1 | PID_ALPHA_SYNUCLEIN_PATHWAY | Alpha-synuclein signaling |
0.0 | 1.2 | PID_CD8_TCR_DOWNSTREAM_PATHWAY | Downstream signaling in naïve CD8+ T cells |
0.0 | 0.9 | PID_IL8_CXCR1_PATHWAY | IL8- and CXCR1-mediated signaling events |
0.0 | 2.7 | PID_MTOR_4PATHWAY | mTOR signaling pathway |
0.0 | 2.4 | PID_TELOMERASE_PATHWAY | Regulation of Telomerase |
0.0 | 1.0 | ST_MYOCYTE_AD_PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
0.0 | 2.0 | ST_FAS_SIGNALING_PATHWAY | Fas Signaling Pathway |
0.0 | 1.0 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
0.0 | 0.8 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
0.0 | 1.0 | PID_AURORA_B_PATHWAY | Aurora B signaling |
0.0 | 1.9 | PID_MYC_ACTIV_PATHWAY | Validated targets of C-MYC transcriptional activation |
0.0 | 0.2 | PID_ERBB2_ERBB3_PATHWAY | ErbB2/ErbB3 signaling events |
0.0 | 0.3 | PID_ERB_GENOMIC_PATHWAY | Validated nuclear estrogen receptor beta network |
0.0 | 1.2 | PID_SMAD2_3NUCLEAR_PATHWAY | Regulation of nuclear SMAD2/3 signaling |
0.0 | 0.5 | PID_NFAT_3PATHWAY | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
0.0 | 0.4 | PID_ANGIOPOIETIN_RECEPTOR_PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
0.0 | 0.6 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
0.0 | 0.4 | PID_IL2_1PATHWAY | IL2-mediated signaling events |
0.0 | 0.4 | PID_PS1_PATHWAY | Presenilin action in Notch and Wnt signaling |
0.0 | 1.8 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
0.0 | 1.9 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
0.0 | 0.1 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
0.0 | 0.5 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
0.0 | 0.2 | SIG_CD40PATHWAYMAP | Genes related to CD40 signaling |
0.0 | 0.2 | PID_NFAT_TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 1.8 | REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
0.1 | 0.4 | REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
0.1 | 3.3 | REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
0.1 | 1.5 | REACTOME_PYRUVATE_METABOLISM | Genes involved in Pyruvate metabolism |
0.1 | 1.1 | REACTOME_METABOLISM_OF_POLYAMINES | Genes involved in Metabolism of polyamines |
0.1 | 1.4 | REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
0.1 | 0.6 | REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
0.1 | 0.6 | REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
0.1 | 1.4 | REACTOME_STRIATED_MUSCLE_CONTRACTION | Genes involved in Striated Muscle Contraction |
0.1 | 1.9 | REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
0.0 | 0.8 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
0.0 | 1.3 | REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
0.0 | 4.3 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
0.0 | 3.6 | REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
0.0 | 0.8 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
0.0 | 1.1 | REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS | Genes involved in Activation of BH3-only proteins |
0.0 | 1.3 | REACTOME_IL_RECEPTOR_SHC_SIGNALING | Genes involved in Interleukin receptor SHC signaling |
0.0 | 0.3 | REACTOME_TIE2_SIGNALING | Genes involved in Tie2 Signaling |
0.0 | 1.8 | REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
0.0 | 1.1 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
0.0 | 0.4 | REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY | Genes involved in Notch-HLH transcription pathway |
0.0 | 0.4 | REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING | Genes involved in Growth hormone receptor signaling |
0.0 | 0.9 | REACTOME_INTERFERON_ALPHA_BETA_SIGNALING | Genes involved in Interferon alpha/beta signaling |
0.0 | 0.4 | REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
0.0 | 0.4 | REACTOME_NEPHRIN_INTERACTIONS | Genes involved in Nephrin interactions |
0.0 | 0.4 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
0.0 | 0.1 | REACTOME_ETHANOL_OXIDATION | Genes involved in Ethanol oxidation |
0.0 | 0.5 | REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
0.0 | 0.2 | REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
0.0 | 0.4 | REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
0.0 | 0.4 | REACTOME_OTHER_SEMAPHORIN_INTERACTIONS | Genes involved in Other semaphorin interactions |
0.0 | 0.3 | REACTOME_HS_GAG_DEGRADATION | Genes involved in HS-GAG degradation |
0.0 | 0.5 | REACTOME_PROSTACYCLIN_SIGNALLING_THROUGH_PROSTACYCLIN_RECEPTOR | Genes involved in Prostacyclin signalling through prostacyclin receptor |
0.0 | 0.4 | REACTOME_RECYCLING_PATHWAY_OF_L1 | Genes involved in Recycling pathway of L1 |
0.0 | 0.6 | REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT | Genes involved in Mitochondrial Protein Import |
0.0 | 0.2 | REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
0.0 | 2.6 | REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
0.0 | 0.1 | REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS | Genes involved in Amine compound SLC transporters |
0.0 | 0.3 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
0.0 | 1.2 | REACTOME_G_ALPHA_I_SIGNALLING_EVENTS | Genes involved in G alpha (i) signalling events |
0.0 | 1.4 | REACTOME_SIGNALING_BY_EGFR_IN_CANCER | Genes involved in Signaling by EGFR in Cancer |