Motif ID: Hnf1a

Z-value: 0.462


Transcription factors associated with Hnf1a:

Gene SymbolEntrez IDGene Name
Hnf1a ENSMUSG00000029556.6 Hnf1a



Activity profile for motif Hnf1a.

activity profile for motif Hnf1a


Sorted Z-values histogram for motif Hnf1a

Sorted Z-values for motif Hnf1a



Network of associatons between targets according to the STRING database.



First level regulatory network of Hnf1a

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_-_53286052 2.475 ENSMUST00000021918.8
Ror2
receptor tyrosine kinase-like orphan receptor 2
chr10_-_30842765 1.422 ENSMUST00000019924.8
Hey2
hairy/enhancer-of-split related with YRPW motif 2
chr17_-_35132050 1.371 ENSMUST00000025249.6
Apom
apolipoprotein M
chr19_-_14598031 1.353 ENSMUST00000167776.2
Tle4
transducin-like enhancer of split 4, homolog of Drosophila E(spl)
chr19_-_14597983 1.253 ENSMUST00000052011.7
Tle4
transducin-like enhancer of split 4, homolog of Drosophila E(spl)
chr9_-_106158109 1.221 ENSMUST00000159809.1
ENSMUST00000162562.1
ENSMUST00000036382.6
ENSMUST00000112543.2
Glyctk



glycerate kinase



chr7_+_141216626 1.091 ENSMUST00000141804.1
ENSMUST00000148975.1
Rassf7

Ras association (RalGDS/AF-6) domain family (N-terminal) member 7

chr7_+_141215852 1.021 ENSMUST00000046890.5
ENSMUST00000133763.1
Rassf7

Ras association (RalGDS/AF-6) domain family (N-terminal) member 7

chr7_-_144751968 1.006 ENSMUST00000155175.1
Ano1
anoctamin 1, calcium activated chloride channel
chr9_+_99629496 1.001 ENSMUST00000131095.1
ENSMUST00000078367.5
ENSMUST00000112885.2
Dzip1l


DAZ interacting protein 1-like


chr5_+_8046077 0.919 ENSMUST00000088786.4
Sri
sorcin
chr2_-_68472138 0.824 ENSMUST00000102715.3
Stk39
serine/threonine kinase 39
chr14_-_70630149 0.813 ENSMUST00000022694.9
Dmtn
dematin actin binding protein
chr9_+_53771499 0.799 ENSMUST00000048670.8
Slc35f2
solute carrier family 35, member F2
chr9_+_99629823 0.755 ENSMUST00000112886.2
Dzip1l
DAZ interacting protein 1-like
chr11_+_78178105 0.686 ENSMUST00000147819.1
Tlcd1
TLC domain containing 1
chr11_-_11898044 0.669 ENSMUST00000066237.3
Ddc
dopa decarboxylase
chr18_+_33464163 0.636 ENSMUST00000097634.3
Gm10549
predicted gene 10549
chr11_-_11898092 0.621 ENSMUST00000178704.1
Ddc
dopa decarboxylase
chr4_-_97778042 0.609 ENSMUST00000146447.1
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr19_+_6105774 0.506 ENSMUST00000044451.3
Naaladl1
N-acetylated alpha-linked acidic dipeptidase-like 1
chr16_+_20651652 0.488 ENSMUST00000007212.8
Psmd2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
chr8_-_95142477 0.462 ENSMUST00000034240.7
ENSMUST00000169748.1
Kifc3

kinesin family member C3

chr9_-_71163224 0.459 ENSMUST00000074465.2
Aqp9
aquaporin 9
chr11_+_3983704 0.455 ENSMUST00000063004.7
Gal3st1
galactose-3-O-sulfotransferase 1
chr11_+_3983636 0.449 ENSMUST00000078757.1
Gal3st1
galactose-3-O-sulfotransferase 1
chr17_+_71204647 0.391 ENSMUST00000126681.1
Lpin2
lipin 2
chr11_+_118428203 0.376 ENSMUST00000124861.1
C1qtnf1
C1q and tumor necrosis factor related protein 1
chr5_+_24428208 0.365 ENSMUST00000115049.2
Slc4a2
solute carrier family 4 (anion exchanger), member 2
chr6_+_38918969 0.351 ENSMUST00000003017.6
Tbxas1
thromboxane A synthase 1, platelet
chr10_+_63061582 0.314 ENSMUST00000020266.8
ENSMUST00000178684.1
Pbld1

phenazine biosynthesis-like protein domain containing 1

chr1_+_125676969 0.310 ENSMUST00000027581.6
Gpr39
G protein-coupled receptor 39
chr1_+_133309778 0.304 ENSMUST00000094557.4
ENSMUST00000183457.1
ENSMUST00000183738.1
ENSMUST00000185157.1
ENSMUST00000184603.1
Golt1a

Kiss1

GOLT1A
golgi transport 1 homolog A (S. cerevisiae)

KiSS-1 metastasis-suppressor

KISS1 isoform e
chr7_+_140763739 0.297 ENSMUST00000026552.7
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
chr15_-_79285502 0.295 ENSMUST00000165408.1
Baiap2l2
BAI1-associated protein 2-like 2
chr2_+_110597298 0.283 ENSMUST00000045972.6
ENSMUST00000111026.2
Slc5a12

solute carrier family 5 (sodium/glucose cotransporter), member 12

chr1_+_172698046 0.261 ENSMUST00000038495.3
Crp
C-reactive protein, pentraxin-related
chr7_-_45062393 0.245 ENSMUST00000129101.1
Prrg2
proline-rich Gla (G-carboxyglutamic acid) polypeptide 2
chr10_+_87859255 0.241 ENSMUST00000105300.2
Igf1
insulin-like growth factor 1
chr5_+_122391878 0.229 ENSMUST00000102525.4
Arpc3
actin related protein 2/3 complex, subunit 3
chr2_-_86347764 0.221 ENSMUST00000099894.2
Olfr1055
olfactory receptor 1055
chr19_-_47919269 0.205 ENSMUST00000095998.5
Itprip
inositol 1,4,5-triphosphate receptor interacting protein
chr13_+_55152640 0.198 ENSMUST00000005452.5
Fgfr4
fibroblast growth factor receptor 4
chr10_+_87859062 0.157 ENSMUST00000095360.4
Igf1
insulin-like growth factor 1
chr2_-_155357392 0.148 ENSMUST00000165234.1
ENSMUST00000077626.6
Pigu

phosphatidylinositol glycan anchor biosynthesis, class U

chr11_-_98022594 0.146 ENSMUST00000103144.3
ENSMUST00000017552.6
ENSMUST00000092736.4
ENSMUST00000107562.1
Cacnb1



calcium channel, voltage-dependent, beta 1 subunit



chrX_-_43167817 0.141 ENSMUST00000115058.1
ENSMUST00000115059.1
Tenm1

teneurin transmembrane protein 1

chrX_+_101377267 0.133 ENSMUST00000052130.7
Gjb1
gap junction protein, beta 1
chr10_-_76110956 0.129 ENSMUST00000120757.1
Slc5a4b
solute carrier family 5 (neutral amino acid transporters, system A), member 4b
chr7_-_79842287 0.121 ENSMUST00000049004.6
Anpep
alanyl (membrane) aminopeptidase
chr3_+_136670076 0.120 ENSMUST00000070198.7
Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chr16_-_52296924 0.091 ENSMUST00000167115.1
Alcam
activated leukocyte cell adhesion molecule
chr7_+_45062429 0.067 ENSMUST00000107830.1
ENSMUST00000003513.3
ENSMUST00000107829.1
ENSMUST00000150609.1
Nosip



nitric oxide synthase interacting protein



chr19_-_30549516 0.037 ENSMUST00000025803.8
Dkk1
dickkopf homolog 1 (Xenopus laevis)
chr6_+_29859374 0.024 ENSMUST00000115238.3
Ahcyl2
S-adenosylhomocysteine hydrolase-like 2
chrX_+_101376359 0.008 ENSMUST00000119080.1
Gjb1
gap junction protein, beta 1
chr3_+_90537242 0.002 ENSMUST00000098911.3
S100a16
S100 calcium binding protein A16
chr14_+_79515618 0.000 ENSMUST00000110835.1
Elf1
E74-like factor 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.5 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223)
0.5 1.4 GO:0003195 tricuspid valve formation(GO:0003195)
0.3 1.4 GO:0050748 negative regulation of lipoprotein metabolic process(GO:0050748)
0.3 0.8 GO:0023016 signal transduction by trans-phosphorylation(GO:0023016) regulation of rubidium ion transmembrane transporter activity(GO:2000686)
0.3 0.8 GO:0035585 calcium-mediated signaling using extracellular calcium source(GO:0035585)
0.2 1.3 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.2 1.0 GO:0015705 iodide transport(GO:0015705)
0.2 0.9 GO:0055118 negative regulation of cardiac muscle contraction(GO:0055118)
0.1 0.4 GO:1904192 regulation of oligodendrocyte apoptotic process(GO:1900141) negative regulation of oligodendrocyte apoptotic process(GO:1900142) cholangiocyte apoptotic process(GO:1902488) regulation of cholangiocyte apoptotic process(GO:1904192) negative regulation of cholangiocyte apoptotic process(GO:1904193)
0.1 0.3 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
0.1 0.3 GO:0035482 gastric motility(GO:0035482) gastric emptying(GO:0035483) negative regulation of gastric acid secretion(GO:0060455)
0.1 0.9 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.1 0.5 GO:0045218 zonula adherens maintenance(GO:0045218)
0.1 0.3 GO:0032275 luteinizing hormone secretion(GO:0032275) positive regulation of gonadotropin secretion(GO:0032278)
0.1 0.2 GO:0061144 alveolar secondary septum development(GO:0061144)
0.1 0.5 GO:0032782 bile acid secretion(GO:0032782)
0.1 0.4 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.0 0.4 GO:2000857 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.0 0.3 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.0 0.1 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244) regulation of connective tissue replacement(GO:1905203)
0.0 0.1 GO:1904659 glucose transmembrane transport(GO:1904659)
0.0 0.1 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.3 GO:0019369 drug metabolic process(GO:0017144) arachidonic acid metabolic process(GO:0019369)
0.0 0.3 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0 0.1 GO:0015868 purine ribonucleotide transport(GO:0015868)
0.0 0.0 GO:1904956 regulation of endodermal cell fate specification(GO:0042663) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) positive regulation of heart induction(GO:1901321) regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066)
0.0 2.0 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.0 0.4 GO:0019432 triglyceride biosynthetic process(GO:0019432)
0.0 0.1 GO:0035814 negative regulation of renal sodium excretion(GO:0035814)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.3 0.9 GO:0042584 chromaffin granule membrane(GO:0042584)
0.2 0.8 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.1 0.4 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.1 1.4 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.5 GO:0005915 zonula adherens(GO:0005915)
0.0 0.5 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540) cytosolic proteasome complex(GO:0031597)
0.0 0.1 GO:0031983 vesicle lumen(GO:0031983)
0.0 0.3 GO:0071439 clathrin complex(GO:0071439)
0.0 0.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 1.0 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.1 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.2 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 1.8 GO:0005814 centriole(GO:0005814)
0.0 0.1 GO:0005922 connexon complex(GO:0005922)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0035939 microsatellite binding(GO:0035939)
0.3 1.3 GO:0036468 aromatic-L-amino-acid decarboxylase activity(GO:0004058) L-dopa decarboxylase activity(GO:0036468)
0.3 1.0 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
0.2 0.9 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733)
0.1 0.4 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 0.5 GO:0015254 glycerol channel activity(GO:0015254)
0.1 0.3 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.1 2.5 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.9 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.3 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.3 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.2 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.5 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.5 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 2.6 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 0.1 GO:0034235 GPI anchor binding(GO:0034235)
0.0 0.2 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.4 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.1 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 1.4 GO:0016209 antioxidant activity(GO:0016209)
0.0 0.4 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 0.3 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.8 GO:0030507 spectrin binding(GO:0030507)
0.0 0.1 GO:0005243 gap junction channel activity(GO:0005243)
0.0 0.0 GO:0048019 receptor antagonist activity(GO:0048019)
0.0 0.1 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.5 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 2.6 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 1.4 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 0.4 PID_IGF1_PATHWAY IGF1 pathway
0.0 0.8 PID_TCR_PATHWAY TCR signaling in naïve CD4+ T cells

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 0.5 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 4.0 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.6 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.3 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.4 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.0 0.9 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.2 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 0.1 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 0.5 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis