Motif ID: E2f8
Z-value: 1.875

Transcription factors associated with E2f8:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
E2f8 | ENSMUSG00000046179.11 | E2f8 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
E2f8 | mm10_v2_chr7_-_48881596_48881619 | 0.95 | 1.3e-20 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
5.8 | 17.3 | GO:0032877 | positive regulation of DNA endoreduplication(GO:0032877) |
5.5 | 22.0 | GO:2000313 | fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313) |
3.0 | 9.1 | GO:0032474 | otolith morphogenesis(GO:0032474) |
2.8 | 8.3 | GO:0036388 | pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) DNA replication preinitiation complex assembly(GO:0071163) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299) |
2.3 | 23.4 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
2.3 | 34.3 | GO:0010216 | maintenance of DNA methylation(GO:0010216) |
2.2 | 6.6 | GO:0045004 | DNA replication proofreading(GO:0045004) |
2.2 | 6.6 | GO:1902174 | positive regulation of keratinocyte apoptotic process(GO:1902174) |
1.7 | 7.0 | GO:0006269 | DNA replication, synthesis of RNA primer(GO:0006269) |
1.4 | 10.1 | GO:0061087 | positive regulation of histone H3-K27 methylation(GO:0061087) |
1.3 | 4.0 | GO:0071930 | negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930) |
1.3 | 13.0 | GO:0046602 | regulation of mitotic centrosome separation(GO:0046602) |
1.2 | 3.6 | GO:0019046 | release from viral latency(GO:0019046) regulation of DNA strand elongation(GO:0060382) |
1.1 | 6.8 | GO:0033600 | negative regulation of mammary gland epithelial cell proliferation(GO:0033600) |
1.1 | 29.1 | GO:0006270 | DNA replication initiation(GO:0006270) |
1.1 | 8.6 | GO:0006398 | mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398) |
1.0 | 17.2 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
0.9 | 5.5 | GO:0002317 | plasma cell differentiation(GO:0002317) positive regulation of viral entry into host cell(GO:0046598) |
0.7 | 8.2 | GO:2000741 | positive regulation of mesenchymal stem cell differentiation(GO:2000741) |
0.7 | 3.5 | GO:0002121 | inter-male aggressive behavior(GO:0002121) response to pheromone(GO:0019236) |
0.5 | 7.9 | GO:0051571 | positive regulation of histone H3-K4 methylation(GO:0051571) |
0.5 | 2.0 | GO:0072737 | response to diamide(GO:0072737) cellular response to diamide(GO:0072738) |
0.5 | 1.8 | GO:0007064 | sister chromatid cohesion(GO:0007062) mitotic sister chromatid cohesion(GO:0007064) |
0.4 | 3.5 | GO:0000056 | ribosomal small subunit export from nucleus(GO:0000056) |
0.4 | 12.4 | GO:0034723 | DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723) |
0.4 | 1.6 | GO:1902626 | assembly of large subunit precursor of preribosome(GO:1902626) |
0.4 | 1.9 | GO:0007089 | traversing start control point of mitotic cell cycle(GO:0007089) |
0.4 | 2.6 | GO:0046549 | phenol-containing compound catabolic process(GO:0019336) retinal cone cell development(GO:0046549) |
0.3 | 7.6 | GO:2000001 | regulation of DNA damage checkpoint(GO:2000001) |
0.3 | 1.0 | GO:1904154 | protein localization to endoplasmic reticulum exit site(GO:0070973) positive regulation of retrograde protein transport, ER to cytosol(GO:1904154) |
0.2 | 1.1 | GO:0006108 | malate metabolic process(GO:0006108) |
0.1 | 7.5 | GO:0090307 | mitotic spindle assembly(GO:0090307) |
0.1 | 5.1 | GO:0043550 | regulation of lipid kinase activity(GO:0043550) |
0.1 | 1.0 | GO:0035562 | negative regulation of chromatin binding(GO:0035562) |
0.1 | 0.6 | GO:0031665 | negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665) |
0.1 | 4.7 | GO:0033045 | regulation of sister chromatid segregation(GO:0033045) |
0.1 | 0.3 | GO:0090521 | glomerular visceral epithelial cell migration(GO:0090521) |
0.1 | 4.4 | GO:0007093 | mitotic cell cycle checkpoint(GO:0007093) |
0.0 | 1.1 | GO:0010971 | positive regulation of G2/M transition of mitotic cell cycle(GO:0010971) |
0.0 | 8.7 | GO:0007179 | transforming growth factor beta receptor signaling pathway(GO:0007179) |
0.0 | 1.8 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
0.0 | 5.1 | GO:0030010 | establishment of cell polarity(GO:0030010) |
0.0 | 0.4 | GO:0006491 | N-glycan processing(GO:0006491) |
0.0 | 10.4 | GO:0007276 | gamete generation(GO:0007276) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
4.1 | 12.4 | GO:0033186 | CAF-1 complex(GO:0033186) |
3.4 | 17.2 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
2.8 | 8.3 | GO:0036387 | nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387) |
2.5 | 37.7 | GO:0042555 | MCM complex(GO:0042555) |
2.4 | 7.2 | GO:1990423 | RZZ complex(GO:1990423) |
2.2 | 6.6 | GO:0043625 | delta DNA polymerase complex(GO:0043625) |
1.5 | 7.5 | GO:0031523 | Myb complex(GO:0031523) |
1.4 | 7.0 | GO:0005658 | alpha DNA polymerase:primase complex(GO:0005658) |
1.3 | 7.6 | GO:0005663 | DNA replication factor C complex(GO:0005663) |
1.2 | 8.6 | GO:0071204 | histone pre-mRNA 3'end processing complex(GO:0071204) |
1.2 | 3.5 | GO:0031074 | nucleocytoplasmic shuttling complex(GO:0031074) |
1.0 | 11.0 | GO:0043240 | Fanconi anaemia nuclear complex(GO:0043240) |
0.8 | 4.0 | GO:0035189 | Rb-E2F complex(GO:0035189) |
0.6 | 39.4 | GO:0005657 | replication fork(GO:0005657) |
0.4 | 12.1 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
0.3 | 3.8 | GO:0001673 | male germ cell nucleus(GO:0001673) |
0.3 | 6.1 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
0.2 | 7.1 | GO:0051233 | spindle midzone(GO:0051233) |
0.2 | 1.0 | GO:0005784 | Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256) |
0.2 | 2.8 | GO:1904115 | axon cytoplasm(GO:1904115) |
0.1 | 2.0 | GO:0001741 | XY body(GO:0001741) |
0.1 | 3.5 | GO:0032590 | dendrite membrane(GO:0032590) |
0.1 | 7.4 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
0.1 | 28.9 | GO:0005667 | transcription factor complex(GO:0005667) |
0.1 | 1.9 | GO:0000776 | kinetochore(GO:0000776) |
0.0 | 14.2 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
0.0 | 18.8 | GO:0030424 | axon(GO:0030424) |
0.0 | 6.8 | GO:0016607 | nuclear speck(GO:0016607) |
0.0 | 1.6 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
0.0 | 0.3 | GO:0044447 | axoneme part(GO:0044447) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
5.5 | 22.2 | GO:0044729 | hemi-methylated DNA-binding(GO:0044729) |
3.4 | 17.2 | GO:0061731 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
3.4 | 10.2 | GO:0035402 | histone kinase activity (H3-T11 specific)(GO:0035402) |
2.9 | 8.6 | GO:0071207 | histone pre-mRNA stem-loop binding(GO:0071207) |
2.3 | 32.3 | GO:0003688 | DNA replication origin binding(GO:0003688) |
2.0 | 7.9 | GO:0071987 | WD40-repeat domain binding(GO:0071987) |
1.6 | 12.4 | GO:0070087 | chromo shadow domain binding(GO:0070087) |
1.2 | 7.5 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
1.1 | 5.5 | GO:0005534 | galactose binding(GO:0005534) |
0.7 | 6.6 | GO:0008296 | 3'-5'-exodeoxyribonuclease activity(GO:0008296) |
0.7 | 7.6 | GO:0003689 | DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) |
0.6 | 3.5 | GO:0070883 | pre-miRNA binding(GO:0070883) |
0.6 | 7.6 | GO:0098505 | G-rich strand telomeric DNA binding(GO:0098505) |
0.5 | 1.8 | GO:0003836 | beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836) |
0.4 | 15.4 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
0.4 | 8.7 | GO:0050431 | transforming growth factor beta binding(GO:0050431) |
0.4 | 21.0 | GO:0019955 | cytokine binding(GO:0019955) |
0.3 | 3.5 | GO:0019992 | diacylglycerol binding(GO:0019992) |
0.3 | 6.6 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
0.3 | 10.7 | GO:0017025 | TBP-class protein binding(GO:0017025) |
0.2 | 1.1 | GO:0016615 | malate dehydrogenase activity(GO:0016615) |
0.2 | 7.0 | GO:0003899 | DNA-directed RNA polymerase activity(GO:0003899) |
0.2 | 5.0 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
0.1 | 25.5 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
0.1 | 2.8 | GO:0005092 | GDP-dissociation inhibitor activity(GO:0005092) |
0.1 | 8.5 | GO:0035064 | methylated histone binding(GO:0035064) |
0.1 | 9.1 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
0.1 | 12.1 | GO:0004386 | helicase activity(GO:0004386) |
0.1 | 2.0 | GO:0008432 | JUN kinase binding(GO:0008432) |
0.1 | 4.5 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
0.1 | 1.0 | GO:0042288 | MHC class I protein binding(GO:0042288) |
0.1 | 4.3 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
0.0 | 11.0 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
0.0 | 4.0 | GO:0001047 | core promoter binding(GO:0001047) |
0.0 | 3.6 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.7 | 15.3 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
0.6 | 28.6 | PID_ATR_PATHWAY | ATR signaling pathway |
0.5 | 19.7 | PID_NECTIN_PATHWAY | Nectin adhesion pathway |
0.4 | 11.0 | PID_FANCONI_PATHWAY | Fanconi anemia pathway |
0.4 | 33.3 | PID_E2F_PATHWAY | E2F transcription factor network |
0.4 | 18.5 | PID_BMP_PATHWAY | BMP receptor signaling |
0.3 | 12.1 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
0.2 | 3.5 | PID_RANBP2_PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
0.2 | 9.1 | PID_ERBB4_PATHWAY | ErbB4 signaling events |
0.2 | 14.0 | PID_CMYB_PATHWAY | C-MYB transcription factor network |
0.2 | 7.6 | PID_FAS_PATHWAY | FAS (CD95) signaling pathway |
0.1 | 5.5 | PID_RAS_PATHWAY | Regulation of Ras family activation |
0.1 | 2.0 | PID_HIV_NEF_PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
0.1 | 4.2 | PID_AJDISS_2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
0.1 | 6.6 | WNT_SIGNALING | Genes related to Wnt-mediated signal transduction |
0.1 | 8.7 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
0.0 | 0.6 | ST_TUMOR_NECROSIS_FACTOR_PATHWAY | Tumor Necrosis Factor Pathway. |
0.0 | 1.1 | PID_REG_GR_PATHWAY | Glucocorticoid receptor regulatory network |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
3.0 | 47.8 | REACTOME_UNWINDING_OF_DNA | Genes involved in Unwinding of DNA |
1.7 | 15.3 | REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
1.7 | 30.4 | REACTOME_G1_S_SPECIFIC_TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
1.6 | 21.2 | REACTOME_PROCESSIVE_SYNTHESIS_ON_THE_LAGGING_STRAND | Genes involved in Processive synthesis on the lagging strand |
0.7 | 22.0 | REACTOME_SIGNALING_BY_BMP | Genes involved in Signaling by BMP |
0.7 | 8.6 | REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
0.7 | 11.8 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
0.6 | 19.7 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
0.5 | 11.0 | REACTOME_FANCONI_ANEMIA_PATHWAY | Genes involved in Fanconi Anemia pathway |
0.2 | 2.6 | REACTOME_AMINE_DERIVED_HORMONES | Genes involved in Amine-derived hormones |
0.2 | 3.5 | REACTOME_MICRORNA_MIRNA_BIOGENESIS | Genes involved in MicroRNA (miRNA) Biogenesis |
0.1 | 7.9 | REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
0.1 | 9.1 | REACTOME_SIGNALING_BY_EGFR_IN_CANCER | Genes involved in Signaling by EGFR in Cancer |
0.0 | 0.4 | REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
0.0 | 3.7 | REACTOME_MRNA_SPLICING | Genes involved in mRNA Splicing |
0.0 | 1.1 | REACTOME_GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
0.0 | 2.5 | REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE | Genes involved in Late Phase of HIV Life Cycle |
0.0 | 1.0 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |