Motif ID: Irf4

Z-value: 0.579


Transcription factors associated with Irf4:

Gene SymbolEntrez IDGene Name
Irf4 ENSMUSG00000021356.3 Irf4



Activity profile for motif Irf4.

activity profile for motif Irf4


Sorted Z-values histogram for motif Irf4

Sorted Z-values for motif Irf4



Network of associatons between targets according to the STRING database.



First level regulatory network of Irf4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_163313661 3.020 ENSMUST00000174397.1
ENSMUST00000075805.6
ENSMUST00000027878.7
Prrx1


paired related homeobox 1


chr11_-_77894096 2.865 ENSMUST00000017597.4
Pipox
pipecolic acid oxidase
chr6_-_87335758 2.044 ENSMUST00000042025.9
Antxr1
anthrax toxin receptor 1
chr3_+_90537306 1.955 ENSMUST00000107335.1
S100a16
S100 calcium binding protein A16
chr3_+_90537242 1.887 ENSMUST00000098911.3
S100a16
S100 calcium binding protein A16
chr1_+_16688405 1.840 ENSMUST00000026881.4
Ly96
lymphocyte antigen 96
chrX_-_134161928 1.791 ENSMUST00000033611.4
Xkrx
X Kell blood group precursor related X linked
chr17_-_6782775 1.713 ENSMUST00000064234.6
Ezr
ezrin
chr6_-_39118211 1.627 ENSMUST00000038398.6
Parp12
poly (ADP-ribose) polymerase family, member 12
chr1_-_14310198 1.555 ENSMUST00000168081.2
ENSMUST00000027066.6
Eya1

eyes absent 1 homolog (Drosophila)

chr14_+_60732906 1.408 ENSMUST00000162945.1
Spata13
spermatogenesis associated 13
chr8_+_84723003 1.390 ENSMUST00000098571.4
G430095P16Rik
RIKEN cDNA G430095P16 gene
chr1_-_97977233 1.343 ENSMUST00000161567.1
Pam
peptidylglycine alpha-amidating monooxygenase
chr2_+_128126030 1.282 ENSMUST00000089634.5
ENSMUST00000019281.7
ENSMUST00000110341.2
ENSMUST00000103211.1
ENSMUST00000103210.1
Bcl2l11




BCL2-like 11 (apoptosis facilitator)




chr11_+_119393060 1.249 ENSMUST00000131035.2
ENSMUST00000093902.5
Rnf213

ring finger protein 213

chr9_-_116175318 1.246 ENSMUST00000061101.4
ENSMUST00000035014.6
Tgfbr2

transforming growth factor, beta receptor II

chr9_+_85842852 1.192 ENSMUST00000098500.3
Tpbg
trophoblast glycoprotein
chr16_-_43664145 1.185 ENSMUST00000096065.4
Tigit
T cell immunoreceptor with Ig and ITIM domains
chr8_-_84773381 1.169 ENSMUST00000109764.1
Nfix
nuclear factor I/X
chr16_+_43235856 1.085 ENSMUST00000146708.1
Zbtb20
zinc finger and BTB domain containing 20
chr4_-_136886187 1.074 ENSMUST00000046384.8
C1qb
complement component 1, q subcomponent, beta polypeptide
chr10_-_41490335 1.060 ENSMUST00000019965.6
Smpd2
sphingomyelin phosphodiesterase 2, neutral
chr13_-_113046357 0.998 ENSMUST00000022282.3
Gpx8
glutathione peroxidase 8 (putative)
chr2_-_127788854 0.948 ENSMUST00000028857.7
ENSMUST00000110357.1
Nphp1

nephronophthisis 1 (juvenile) homolog (human)

chr13_-_81570640 0.895 ENSMUST00000109565.2
Gpr98
G protein-coupled receptor 98
chr16_+_35938972 0.862 ENSMUST00000023622.6
ENSMUST00000114877.1
Parp9

poly (ADP-ribose) polymerase family, member 9

chr14_-_66124482 0.822 ENSMUST00000070515.1
Ephx2
epoxide hydrolase 2, cytoplasmic
chr5_-_104021919 0.815 ENSMUST00000031251.9
Hsd17b11
hydroxysteroid (17-beta) dehydrogenase 11
chr5_-_104021799 0.767 ENSMUST00000119025.1
Hsd17b11
hydroxysteroid (17-beta) dehydrogenase 11
chr16_-_5255923 0.748 ENSMUST00000139584.1
ENSMUST00000064635.5
Fam86

family with sequence similarity 86

chr1_-_84935089 0.744 ENSMUST00000027422.5
Slc16a14
solute carrier family 16 (monocarboxylic acid transporters), member 14
chr3_+_138065052 0.737 ENSMUST00000163080.2
1110002E22Rik
RIKEN cDNA 1110002E22 gene
chr7_+_4460687 0.701 ENSMUST00000167298.1
ENSMUST00000171445.1
Eps8l1

EPS8-like 1

chr4_-_89311021 0.653 ENSMUST00000097981.4
Cdkn2b
cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
chr3_+_95526777 0.630 ENSMUST00000015667.2
ENSMUST00000116304.2
Ctss

cathepsin S

chr9_+_45042425 0.621 ENSMUST00000034600.4
Mpzl2
myelin protein zero-like 2
chr15_-_50889691 0.614 ENSMUST00000165201.2
ENSMUST00000184458.1
Trps1

trichorhinophalangeal syndrome I (human)

chr19_-_24225015 0.609 ENSMUST00000099558.4
Tjp2
tight junction protein 2
chr16_-_35939082 0.602 ENSMUST00000081933.7
ENSMUST00000114885.1
Dtx3l

deltex 3-like (Drosophila)

chr2_+_71453276 0.573 ENSMUST00000037210.8
Metap1d
methionyl aminopeptidase type 1D (mitochondrial)
chr7_-_141010759 0.549 ENSMUST00000026565.6
Ifitm3
interferon induced transmembrane protein 3
chr7_-_65370908 0.541 ENSMUST00000032729.6
Tjp1
tight junction protein 1
chr2_-_51934644 0.529 ENSMUST00000165313.1
Rbm43
RNA binding motif protein 43
chr10_+_126978690 0.527 ENSMUST00000105256.2
Ctdsp2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
chr17_+_34564268 0.506 ENSMUST00000015612.7
Notch4
notch 4
chr3_-_67375163 0.504 ENSMUST00000166353.1
Gm17402
predicted gene, 17402
chr16_-_24393588 0.478 ENSMUST00000181640.1
1110054M08Rik
RIKEN cDNA 1110054M08 gene
chr8_+_105170668 0.464 ENSMUST00000109395.1
ENSMUST00000109394.1
ENSMUST00000052209.2
ENSMUST00000109392.1
Cbfb



core binding factor beta



chr5_+_36796228 0.463 ENSMUST00000181278.1
Gm26605
predicted gene, 26605
chrX_+_150547375 0.459 ENSMUST00000066337.6
ENSMUST00000112715.1
Alas2

aminolevulinic acid synthase 2, erythroid

chr16_-_26371828 0.454 ENSMUST00000023154.2
Cldn1
claudin 1
chr1_+_61638819 0.449 ENSMUST00000138768.1
ENSMUST00000075374.3
Pard3b

par-3 partitioning defective 3 homolog B (C. elegans)

chr8_+_128685654 0.440 ENSMUST00000090006.5
Itgb1
integrin beta 1 (fibronectin receptor beta)
chr11_-_101551837 0.425 ENSMUST00000017290.4
Brca1
breast cancer 1
chr6_+_71282280 0.424 ENSMUST00000080949.7
Krcc1
lysine-rich coiled-coil 1
chr10_+_86022189 0.413 ENSMUST00000120344.1
ENSMUST00000117597.1
Fbxo7

F-box protein 7

chr17_+_47410247 0.411 ENSMUST00000177586.1
Gm5814
predicted pseudogene 5814
chr4_-_4138817 0.399 ENSMUST00000133567.1
Penk
preproenkephalin
chr10_-_18234930 0.392 ENSMUST00000052648.8
ENSMUST00000080860.6
ENSMUST00000173243.1
Ccdc28a


coiled-coil domain containing 28A


chr3_+_89421619 0.386 ENSMUST00000094378.3
ENSMUST00000137793.1
Shc1

src homology 2 domain-containing transforming protein C1

chr7_+_35586232 0.385 ENSMUST00000040844.9
Ankrd27
ankyrin repeat domain 27 (VPS9 domain)
chr6_+_82041623 0.371 ENSMUST00000042974.8
Eva1a
eva-1 homolog A (C. elegans)
chr4_-_156200818 0.354 ENSMUST00000085425.4
Isg15
ISG15 ubiquitin-like modifier
chr7_-_16286744 0.352 ENSMUST00000150528.2
ENSMUST00000118976.2
ENSMUST00000146609.2
Ccdc9


coiled-coil domain containing 9


chr17_-_30612613 0.339 ENSMUST00000167624.1
ENSMUST00000024823.6
Glo1

glyoxalase 1

chr9_+_65346066 0.337 ENSMUST00000048184.2
Pdcd7
programmed cell death 7
chrM_+_8600 0.332 ENSMUST00000082409.1
mt-Co3
mitochondrially encoded cytochrome c oxidase III
chr13_-_23710714 0.328 ENSMUST00000091707.6
ENSMUST00000006787.7
ENSMUST00000091706.6
Hfe


hemochromatosis


chr15_+_102977032 0.308 ENSMUST00000001706.6
Hoxc9
homeobox C9
chr10_+_128706251 0.300 ENSMUST00000054125.8
Pmel
premelanosome protein
chr4_-_123139929 0.298 ENSMUST00000030404.4
Ppie
peptidylprolyl isomerase E (cyclophilin E)
chr3_-_142395661 0.283 ENSMUST00000029941.9
ENSMUST00000168967.2
ENSMUST00000090134.5
ENSMUST00000058626.8
Pdlim5



PDZ and LIM domain 5



chr4_-_107178282 0.267 ENSMUST00000058585.7
Tceanc2
transcription elongation factor A (SII) N-terminal and central domain containing 2
chr2_-_52335134 0.266 ENSMUST00000075301.3
Neb
nebulin
chr17_+_34203527 0.262 ENSMUST00000025197.5
Tap2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
chr3_+_142496924 0.259 ENSMUST00000090127.2
Gbp5
guanylate binding protein 5
chr18_+_7869707 0.245 ENSMUST00000166062.1
ENSMUST00000169010.1
Wac

WW domain containing adaptor with coiled-coil

chr13_-_18031616 0.215 ENSMUST00000099736.2
Vdac3-ps1
voltage-dependent anion channel 3, pseudogene 1
chr18_+_37484955 0.212 ENSMUST00000053856.4
Pcdhb17
protocadherin beta 17
chr7_+_58658181 0.208 ENSMUST00000168747.1
Atp10a
ATPase, class V, type 10A
chr5_+_24393640 0.196 ENSMUST00000138168.1
ENSMUST00000115077.1
Abcb8

ATP-binding cassette, sub-family B (MDR/TAP), member 8

chr2_-_131175201 0.183 ENSMUST00000110218.2
Spef1
sperm flagellar 1
chr5_+_28165690 0.181 ENSMUST00000036177.7
En2
engrailed 2
chr11_+_69966896 0.171 ENSMUST00000151515.1
Cldn7
claudin 7
chrM_+_9452 0.168 ENSMUST00000082411.1
mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chrX_+_94367112 0.167 ENSMUST00000113898.1
Apoo
apolipoprotein O
chr16_+_65520503 0.150 ENSMUST00000176330.1
ENSMUST00000004964.8
ENSMUST00000176038.1
Pou1f1


POU domain, class 1, transcription factor 1


chr11_-_3539228 0.141 ENSMUST00000075118.3
ENSMUST00000136243.1
ENSMUST00000170588.1
ENSMUST00000020721.8
Smtn



smoothelin



chr11_+_78245743 0.131 ENSMUST00000002133.8
Sdf2
stromal cell derived factor 2
chr17_+_35424870 0.122 ENSMUST00000113879.3
H2-Q6
histocompatibility 2, Q region locus 6
chr13_+_23555023 0.115 ENSMUST00000045301.6
Hist1h1d
histone cluster 1, H1d
chrX_+_94636066 0.112 ENSMUST00000096368.3
Gspt2
G1 to S phase transition 2
chr1_+_66468364 0.109 ENSMUST00000061620.9
Unc80
unc-80 homolog (C. elegans)
chr19_+_33822908 0.102 ENSMUST00000042061.6
Gm5519
predicted pseudogene 5519
chr16_+_24393350 0.101 ENSMUST00000038053.6
Lpp
LIM domain containing preferred translocation partner in lipoma
chr1_-_93101825 0.099 ENSMUST00000112958.2
Kif1a
kinesin family member 1A
chrX_+_136707976 0.098 ENSMUST00000055104.5
Tceal1
transcription elongation factor A (SII)-like 1
chr2_+_167062934 0.096 ENSMUST00000125674.1
1500012F01Rik
RIKEN cDNA 1500012F01 gene
chr11_+_78343475 0.095 ENSMUST00000002127.7
ENSMUST00000108295.1
Unc119

unc-119 homolog (C. elegans)

chr2_-_131174653 0.093 ENSMUST00000127987.1
Spef1
sperm flagellar 1
chr10_-_78352053 0.090 ENSMUST00000105388.1
Agpat3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr14_-_54409469 0.088 ENSMUST00000000984.4
Slc7a7
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
chr2_-_9878580 0.080 ENSMUST00000102976.3
Gata3
GATA binding protein 3
chr7_-_126396715 0.075 ENSMUST00000075671.4
Nfatc2ip
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 interacting protein
chr11_-_101171302 0.068 ENSMUST00000164474.1
ENSMUST00000043397.7
Plekhh3

pleckstrin homology domain containing, family H (with MyTH4 domain) member 3

chr10_-_111997204 0.066 ENSMUST00000074805.5
Glipr1
GLI pathogenesis-related 1 (glioma)
chr1_+_132008285 0.065 ENSMUST00000146432.1
Elk4
ELK4, member of ETS oncogene family
chr1_-_57406443 0.058 ENSMUST00000160837.1
ENSMUST00000161780.1
Tyw5

tRNA-yW synthesizing protein 5

chr12_-_4477138 0.057 ENSMUST00000085814.3
Ncoa1
nuclear receptor coactivator 1
chr9_+_105053239 0.055 ENSMUST00000035177.8
ENSMUST00000149243.1
Mrpl3

mitochondrial ribosomal protein L3

chr11_+_72689997 0.052 ENSMUST00000155998.1
Ankfy1
ankyrin repeat and FYVE domain containing 1
chr1_-_93101854 0.051 ENSMUST00000171796.1
ENSMUST00000171556.1
Kif1a

kinesin family member 1A

chr10_-_78351711 0.043 ENSMUST00000105390.1
Agpat3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr13_-_100616911 0.043 ENSMUST00000168772.1
ENSMUST00000163163.1
ENSMUST00000022137.7
Marveld2


MARVEL (membrane-associating) domain containing 2


chr11_+_43474276 0.020 ENSMUST00000173002.1
ENSMUST00000057679.3
C1qtnf2

C1q and tumor necrosis factor related protein 2

chr6_+_35177386 0.019 ENSMUST00000043815.9
Nup205
nucleoporin 205
chr1_-_159168642 0.016 ENSMUST00000077309.1
Gm4953
predicted pseudogene 4953
chr8_-_78821136 0.012 ENSMUST00000130325.1
ENSMUST00000051867.6
Lsm6

LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)

chr7_-_62420139 0.012 ENSMUST00000094340.3
Mkrn3
makorin, ring finger protein, 3
chr9_-_108428484 0.011 ENSMUST00000076592.2
Ccdc36
coiled-coil domain containing 36
chr18_-_70530138 0.007 ENSMUST00000161542.1
ENSMUST00000159389.1
Poli

polymerase (DNA directed), iota

chr10_-_78351690 0.007 ENSMUST00000166360.1
Agpat3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr1_+_175632169 0.004 ENSMUST00000097458.3
Kmo
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr7_+_28741968 0.003 ENSMUST00000094632.4
Sars2
seryl-aminoacyl-tRNA synthetase 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 2.9 GO:0006553 lysine metabolic process(GO:0006553)
0.7 2.0 GO:1903054 negative regulation of extracellular matrix organization(GO:1903054)
0.6 1.7 GO:1900041 intestinal D-glucose absorption(GO:0001951) negative regulation of interleukin-2 secretion(GO:1900041) terminal web assembly(GO:1902896)
0.5 1.4 GO:1903348 positive regulation of bicellular tight junction assembly(GO:1903348)
0.4 1.2 GO:0003274 endocardial cushion fusion(GO:0003274)
0.4 1.6 GO:0006710 androgen catabolic process(GO:0006710)
0.4 1.8 GO:0032497 detection of lipopolysaccharide(GO:0032497)
0.3 1.3 GO:0052151 positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation of apoptotic process by virus(GO:0060139) apoptotic process involved in embryonic digit morphogenesis(GO:1902263)
0.3 0.8 GO:0002538 arachidonic acid metabolite production involved in inflammatory response(GO:0002538) olefin metabolic process(GO:1900673)
0.3 0.3 GO:0030832 regulation of actin filament length(GO:0030832)
0.3 1.6 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.2 3.0 GO:0048664 neuron fate determination(GO:0048664)
0.2 0.6 GO:1903011 negative regulation of bone development(GO:1903011)
0.1 0.6 GO:0002589 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589)
0.1 0.4 GO:0007161 calcium-independent cell-matrix adhesion(GO:0007161)
0.1 0.4 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
0.1 1.2 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.1 1.3 GO:0009404 toxin metabolic process(GO:0009404)
0.1 0.7 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.1 0.9 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
0.1 0.5 GO:1903847 regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.1 0.4 GO:2000987 positive regulation of fear response(GO:1903367) positive regulation of behavioral fear response(GO:2000987)
0.1 0.4 GO:1990839 response to endothelin(GO:1990839)
0.1 1.2 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.1 0.3 GO:0032621 interleukin-18 production(GO:0032621)
0.1 0.9 GO:0032695 negative regulation of interleukin-12 production(GO:0032695)
0.1 0.5 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.1 0.4 GO:1903207 neuron death in response to hydrogen peroxide(GO:0036476) regulation of hydrogen peroxide-induced neuron death(GO:1903207) negative regulation of hydrogen peroxide-induced neuron death(GO:1903208)
0.1 1.1 GO:0006958 complement activation, classical pathway(GO:0006958)
0.1 0.7 GO:0060253 negative regulation of glial cell proliferation(GO:0060253)
0.1 0.2 GO:0060126 somatotropin secreting cell differentiation(GO:0060126)
0.0 0.2 GO:0071894 histone H2B conserved C-terminal lysine ubiquitination(GO:0071894)
0.0 0.4 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.0 0.4 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.6 GO:0010447 response to acidic pH(GO:0010447)
0.0 0.1 GO:0002184 cytoplasmic translational termination(GO:0002184)
0.0 0.3 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.0 0.3 GO:0048023 positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.0 3.8 GO:0051592 response to calcium ion(GO:0051592)
0.0 0.1 GO:0000821 regulation of arginine metabolic process(GO:0000821)
0.0 0.5 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.0 0.5 GO:0042541 hemoglobin biosynthetic process(GO:0042541)
0.0 0.3 GO:0070234 positive regulation of T cell apoptotic process(GO:0070234)
0.0 0.1 GO:0035799 ureter maturation(GO:0035799) cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) regulation of ureteric bud formation(GO:0072106) positive regulation of ureteric bud formation(GO:0072107) cell-cell signaling involved in metanephros development(GO:0072204) regulation of DNA demethylation(GO:1901535) negative regulation of DNA demethylation(GO:1901536)
0.0 0.6 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.0 1.1 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 0.1 GO:0031590 wybutosine metabolic process(GO:0031590) wybutosine biosynthetic process(GO:0031591)
0.0 0.1 GO:1904017 response to Thyroglobulin triiodothyronine(GO:1904016) cellular response to Thyroglobulin triiodothyronine(GO:1904017)
0.0 0.1 GO:1900186 negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of caveolin-mediated endocytosis(GO:2001286)
0.0 1.4 GO:0046847 filopodium assembly(GO:0046847)
0.0 0.5 GO:0060216 definitive hemopoiesis(GO:0060216)
0.0 0.1 GO:0016584 nucleosome positioning(GO:0016584)
0.0 1.1 GO:0032755 positive regulation of interleukin-6 production(GO:0032755)
0.0 0.6 GO:0010390 histone monoubiquitination(GO:0010390)
0.0 0.2 GO:1990403 embryonic brain development(GO:1990403)
0.0 0.2 GO:0042407 cristae formation(GO:0042407)
0.0 0.2 GO:0032463 negative regulation of protein homooligomerization(GO:0032463)
0.0 0.3 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.5 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.0 0.1 GO:0034058 endosomal vesicle fusion(GO:0034058)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0098592 cytoplasmic side of apical plasma membrane(GO:0098592)
0.3 1.8 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.2 2.0 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 0.4 GO:0034679 integrin alpha2-beta1 complex(GO:0034666) integrin alpha3-beta1 complex(GO:0034667) integrin alpha9-beta1 complex(GO:0034679)
0.1 0.4 GO:0032280 symmetric synapse(GO:0032280)
0.1 0.4 GO:1990037 Lewy body core(GO:1990037)
0.1 0.4 GO:0070531 BRCA1-A complex(GO:0070531)
0.1 0.5 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 0.3 GO:1990357 terminal web(GO:1990357)
0.1 0.7 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 0.3 GO:0032585 multivesicular body membrane(GO:0032585)
0.1 0.4 GO:0097422 tubular endosome(GO:0097422)
0.0 0.1 GO:0018444 translation release factor complex(GO:0018444)
0.0 0.3 GO:0042825 TAP complex(GO:0042825)
0.0 0.6 GO:0005921 gap junction(GO:0005921)
0.0 0.9 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 1.3 GO:0030667 secretory granule membrane(GO:0030667)
0.0 1.6 GO:0005811 lipid particle(GO:0005811)
0.0 2.0 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.2 GO:0061617 MICOS complex(GO:0061617)
0.0 1.7 GO:0005901 caveola(GO:0005901)
0.0 1.1 GO:0005581 collagen trimer(GO:0005581)
0.0 1.5 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 2.7 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.3 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.6 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.1 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 0.1 GO:0042612 MHC class I protein complex(GO:0042612)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.9 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.6 1.8 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.4 1.3 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.3 1.2 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.2 1.6 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.2 0.8 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.2 0.5 GO:0016748 succinyltransferase activity(GO:0016748)
0.1 1.1 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 1.7 GO:0044548 S100 protein binding(GO:0044548)
0.1 2.4 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 0.4 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.1 0.4 GO:0048408 epidermal growth factor binding(GO:0048408)
0.1 3.0 GO:0071837 HMG box domain binding(GO:0071837)
0.1 2.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 0.3 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
0.1 0.5 GO:0071253 connexin binding(GO:0071253)
0.1 0.5 GO:0008420 CTD phosphatase activity(GO:0008420)
0.1 0.4 GO:0001515 opioid peptide activity(GO:0001515)
0.0 0.7 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 1.0 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.3 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.0 2.7 GO:0005518 collagen binding(GO:0005518)
0.0 1.3 GO:0070840 dynein complex binding(GO:0070840)
0.0 0.3 GO:0039706 co-receptor binding(GO:0039706)
0.0 0.5 GO:0001618 virus receptor activity(GO:0001618)
0.0 0.4 GO:0031386 protein tag(GO:0031386)
0.0 0.1 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 0.3 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 0.7 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 0.5 GO:0005112 Notch binding(GO:0005112)
0.0 0.1 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 1.6 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.1 GO:0046977 TAP binding(GO:0046977)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.1 2.2 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.1 1.8 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 1.2 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 0.7 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.4 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.5 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.7 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.4 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 3.8 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 0.5 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.5 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 0.9 PID_AP1_PATHWAY AP-1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.2 1.1 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.2 1.8 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.2 1.1 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 1.2 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 1.3 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.5 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.4 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 1.4 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.0 1.1 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.6 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 0.4 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.5 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.4 REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING Genes involved in SHC1 events in EGFR signaling
0.0 0.7 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.3 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.4 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.3 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction