Motif ID: Hoxd12

Z-value: 1.379


Transcription factors associated with Hoxd12:

Gene SymbolEntrez IDGene Name
Hoxd12 ENSMUSG00000001823.4 Hoxd12



Activity profile for motif Hoxd12.

activity profile for motif Hoxd12


Sorted Z-values histogram for motif Hoxd12

Sorted Z-values for motif Hoxd12



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxd12

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_8710734 17.991 ENSMUST00000005493.7
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr15_-_8710409 15.211 ENSMUST00000157065.1
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr13_-_84064772 13.826 ENSMUST00000182477.1
Gm17750
predicted gene, 17750
chr4_-_154636831 12.835 ENSMUST00000030902.6
ENSMUST00000105637.1
ENSMUST00000070313.7
ENSMUST00000105636.1
ENSMUST00000105638.2
ENSMUST00000097759.2
ENSMUST00000124771.1
Prdm16






PR domain containing 16






chr4_+_144893127 12.244 ENSMUST00000142808.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr4_+_144892813 11.833 ENSMUST00000105744.1
ENSMUST00000171001.1
Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr1_-_56969864 11.602 ENSMUST00000177424.1
Satb2
special AT-rich sequence binding protein 2
chr4_+_144893077 9.139 ENSMUST00000154208.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr16_+_42907563 8.851 ENSMUST00000151244.1
ENSMUST00000114694.2
Zbtb20

zinc finger and BTB domain containing 20

chr1_-_56969827 8.665 ENSMUST00000176759.1
Satb2
special AT-rich sequence binding protein 2
chr2_+_73271925 7.921 ENSMUST00000090813.5
Sp9
trans-acting transcription factor 9
chr1_+_19103022 6.151 ENSMUST00000037294.7
Tfap2d
transcription factor AP-2, delta
chr2_-_36104060 6.021 ENSMUST00000112961.3
ENSMUST00000112966.3
Lhx6

LIM homeobox protein 6

chr10_-_42583628 5.830 ENSMUST00000019938.4
Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr1_-_45503282 5.694 ENSMUST00000086430.4
Col5a2
collagen, type V, alpha 2
chr14_-_118052235 5.448 ENSMUST00000022725.2
Dct
dopachrome tautomerase
chr19_+_55741810 5.212 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr1_+_159737510 5.186 ENSMUST00000111669.3
Tnr
tenascin R
chr5_-_62766153 4.791 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr3_+_122419772 4.562 ENSMUST00000029766.4
Bcar3
breast cancer anti-estrogen resistance 3
chr3_+_9403049 4.199 ENSMUST00000180874.1
ENSMUST00000181331.1
ENSMUST00000181930.1
C030034L19Rik


RIKEN cDNA C030034L19 gene


chr13_-_97747373 4.099 ENSMUST00000123535.1
5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr13_-_97747399 4.032 ENSMUST00000144993.1
5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr1_-_165934900 4.013 ENSMUST00000069609.5
ENSMUST00000111427.2
ENSMUST00000111426.4
Pou2f1


POU domain, class 2, transcription factor 1


chr6_+_125215551 3.962 ENSMUST00000032487.7
ENSMUST00000100942.2
ENSMUST00000063588.8
Vamp1


vesicle-associated membrane protein 1


chr1_-_163313661 3.794 ENSMUST00000174397.1
ENSMUST00000075805.6
ENSMUST00000027878.7
Prrx1


paired related homeobox 1


chr17_+_3397189 3.469 ENSMUST00000072156.6
Tiam2
T cell lymphoma invasion and metastasis 2
chr15_+_25773985 2.980 ENSMUST00000125667.1
Myo10
myosin X
chr1_-_152625212 2.950 ENSMUST00000027760.7
Rgl1
ral guanine nucleotide dissociation stimulator,-like 1
chr11_-_109473220 2.925 ENSMUST00000070872.6
Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr2_+_105682463 2.924 ENSMUST00000140173.1
ENSMUST00000135412.1
ENSMUST00000138365.1
ENSMUST00000145744.1
Pax6



paired box gene 6



chr3_+_66985680 2.851 ENSMUST00000065047.6
Rsrc1
arginine/serine-rich coiled-coil 1
chr13_-_101692624 2.533 ENSMUST00000035532.6
Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr19_-_6987621 2.522 ENSMUST00000130048.1
ENSMUST00000025914.6
Vegfb

vascular endothelial growth factor B

chr4_-_88033328 2.467 ENSMUST00000078090.5
Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr18_-_35215008 2.344 ENSMUST00000091636.3
Lrrtm2
leucine rich repeat transmembrane neuronal 2
chr5_+_107497762 2.290 ENSMUST00000152474.1
ENSMUST00000060553.7
A830010M20Rik

RIKEN cDNA A830010M20 gene

chr4_-_82505707 2.290 ENSMUST00000107248.1
ENSMUST00000107247.1
Nfib

nuclear factor I/B

chr7_-_37772868 2.289 ENSMUST00000176205.1
Zfp536
zinc finger protein 536
chr4_-_82850721 2.216 ENSMUST00000139401.1
Zdhhc21
zinc finger, DHHC domain containing 21
chr1_-_69108039 2.141 ENSMUST00000121473.1
Erbb4
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
chr17_-_51826562 2.033 ENSMUST00000024720.4
ENSMUST00000129667.1
ENSMUST00000156051.1
ENSMUST00000169480.1
ENSMUST00000148559.1
Satb1




special AT-rich sequence binding protein 1




chr10_-_13324160 2.014 ENSMUST00000105545.4
Phactr2
phosphatase and actin regulator 2
chr5_+_107497718 1.907 ENSMUST00000112671.2
A830010M20Rik
RIKEN cDNA A830010M20 gene
chr11_-_109472611 1.894 ENSMUST00000168740.1
Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr4_-_82505749 1.819 ENSMUST00000107245.2
ENSMUST00000107246.1
Nfib

nuclear factor I/B

chr10_+_90071095 1.734 ENSMUST00000183109.1
Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr5_-_62765618 1.599 ENSMUST00000159470.1
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr1_+_81077274 1.528 ENSMUST00000068275.5
ENSMUST00000113494.2
Nyap2

neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2

chr6_+_15185203 1.517 ENSMUST00000154448.1
Foxp2
forkhead box P2
chr1_+_81077204 1.456 ENSMUST00000123720.1
Nyap2
neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2
chr8_-_47352348 1.401 ENSMUST00000110367.2
Stox2
storkhead box 2
chr4_-_11981265 1.363 ENSMUST00000098260.2
Gm10604
predicted gene 10604
chr14_+_66868850 1.272 ENSMUST00000100453.1
Gm5464
predicted gene 5464
chr10_-_30655859 1.264 ENSMUST00000092610.4
Ncoa7
nuclear receptor coactivator 7
chr16_+_11405648 1.229 ENSMUST00000096273.2
Snx29
sorting nexin 29
chr17_+_91236787 1.214 ENSMUST00000057074.8
Gm6741
predicted gene 6741
chr3_+_66985647 1.205 ENSMUST00000162362.1
ENSMUST00000065074.7
Rsrc1

arginine/serine-rich coiled-coil 1

chr9_+_62858085 1.198 ENSMUST00000034777.6
ENSMUST00000163820.1
Calml4

calmodulin-like 4

chr4_+_136284658 1.195 ENSMUST00000144217.1
Zfp46
zinc finger protein 46
chr9_-_13245741 1.195 ENSMUST00000110582.2
Jrkl
jerky homolog-like (mouse)
chr10_+_4611971 1.191 ENSMUST00000105590.1
ENSMUST00000067086.7
Esr1

estrogen receptor 1 (alpha)

chr9_+_120929216 1.188 ENSMUST00000130466.1
Ctnnb1
catenin (cadherin associated protein), beta 1
chr7_-_100583072 1.185 ENSMUST00000152876.1
ENSMUST00000150042.1
Mrpl48

mitochondrial ribosomal protein L48

chr17_-_35897073 1.114 ENSMUST00000150056.1
ENSMUST00000156817.1
ENSMUST00000146451.1
ENSMUST00000148482.1
2310061I04Rik



RIKEN cDNA 2310061I04 gene



chr4_+_136284708 1.096 ENSMUST00000130223.1
Zfp46
zinc finger protein 46
chr5_+_19907502 1.053 ENSMUST00000101558.3
Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr6_-_119388671 0.977 ENSMUST00000169744.1
Adipor2
adiponectin receptor 2
chr2_-_45117349 0.947 ENSMUST00000176438.2
Zeb2
zinc finger E-box binding homeobox 2
chr11_+_29463735 0.927 ENSMUST00000155854.1
Ccdc88a
coiled coil domain containing 88A
chr1_-_44118757 0.923 ENSMUST00000027213.7
ENSMUST00000065767.2
Kdelc1

KDEL (Lys-Asp-Glu-Leu) containing 1

chr3_+_66985700 0.910 ENSMUST00000046542.6
ENSMUST00000162693.1
Rsrc1

arginine/serine-rich coiled-coil 1

chr3_+_66985947 0.902 ENSMUST00000161726.1
ENSMUST00000160504.1
Rsrc1

arginine/serine-rich coiled-coil 1

chr5_+_31054821 0.875 ENSMUST00000174367.1
ENSMUST00000170329.1
ENSMUST00000031049.6
Cad


carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase


chr5_+_31054766 0.871 ENSMUST00000013773.5
ENSMUST00000114646.1
Cad

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

chr1_-_128102412 0.857 ENSMUST00000112538.1
ENSMUST00000086614.5
Zranb3

zinc finger, RAN-binding domain containing 3

chr15_+_81936753 0.747 ENSMUST00000038757.7
Csdc2
cold shock domain containing C2, RNA binding
chr1_+_153874335 0.725 ENSMUST00000055314.3
Gm5531
predicted gene 5531
chr15_+_81936911 0.704 ENSMUST00000135663.1
Csdc2
cold shock domain containing C2, RNA binding
chr9_-_77347816 0.693 ENSMUST00000184138.1
ENSMUST00000184006.1
ENSMUST00000185144.1
ENSMUST00000034910.9
Mlip



muscular LMNA-interacting protein



chr3_-_126998408 0.689 ENSMUST00000182764.1
ENSMUST00000044443.8
Ank2

ankyrin 2, brain

chr2_+_71786923 0.666 ENSMUST00000112101.1
ENSMUST00000028522.3
Itga6

integrin alpha 6

chr12_+_33147754 0.650 ENSMUST00000146040.1
ENSMUST00000125192.1
Atxn7l1

ataxin 7-like 1

chr16_-_50432340 0.650 ENSMUST00000066037.6
ENSMUST00000089399.4
ENSMUST00000089404.3
ENSMUST00000114477.1
ENSMUST00000138166.1
Bbx




bobby sox homolog (Drosophila)




chr13_+_80883403 0.594 ENSMUST00000099356.2
Arrdc3
arrestin domain containing 3
chr16_+_65520503 0.592 ENSMUST00000176330.1
ENSMUST00000004964.8
ENSMUST00000176038.1
Pou1f1


POU domain, class 1, transcription factor 1


chr5_-_73256555 0.560 ENSMUST00000101127.5
ENSMUST00000171179.1
Fryl
Fryl
furry homolog-like (Drosophila)
furry homolog-like (Drosophila)
chr2_+_116900152 0.526 ENSMUST00000126467.1
ENSMUST00000128305.1
ENSMUST00000155323.1
D330050G23Rik


RIKEN cDNA D330050G23 gene


chr4_-_133968611 0.485 ENSMUST00000102552.1
Hmgn2
high mobility group nucleosomal binding domain 2
chr7_+_30565410 0.481 ENSMUST00000043850.7
Igflr1
IGF-like family receptor 1
chr1_+_137928100 0.478 ENSMUST00000054333.2
A130050O07Rik
RIKEN cDNA A130050O07 gene
chr5_-_24030649 0.474 ENSMUST00000030849.6
Fam126a
family with sequence similarity 126, member A
chr9_-_77347787 0.470 ENSMUST00000184848.1
ENSMUST00000184415.1
Mlip

muscular LMNA-interacting protein

chr2_-_66410064 0.453 ENSMUST00000112366.1
Scn1a
sodium channel, voltage-gated, type I, alpha
chr1_+_63176818 0.385 ENSMUST00000129339.1
Eef1b2
eukaryotic translation elongation factor 1 beta 2
chr10_+_119992916 0.384 ENSMUST00000105261.2
Grip1
glutamate receptor interacting protein 1
chr17_+_34263209 0.378 ENSMUST00000040828.5
H2-Ab1
histocompatibility 2, class II antigen A, beta 1
chr2_-_180824596 0.350 ENSMUST00000148700.1
Gm14340
predicted gene 14340
chr3_-_87768932 0.340 ENSMUST00000173184.1
ENSMUST00000172621.1
ENSMUST00000174759.1
ENSMUST00000172590.1
ENSMUST00000079083.5
Pear1




platelet endothelial aggregation receptor 1




chr9_-_8042785 0.328 ENSMUST00000065291.1
9230110C19Rik
RIKEN cDNA 9230110C19 gene
chr8_+_69902178 0.306 ENSMUST00000050373.5
Tssk6
testis-specific serine kinase 6
chr15_+_81744848 0.274 ENSMUST00000109554.1
Zc3h7b
zinc finger CCCH type containing 7B
chr10_+_42583787 0.270 ENSMUST00000105497.1
ENSMUST00000144806.1
Ostm1

osteopetrosis associated transmembrane protein 1

chr3_+_41024369 0.262 ENSMUST00000099121.3
Larp1b
La ribonucleoprotein domain family, member 1B
chr11_-_118355496 0.260 ENSMUST00000017610.3
Timp2
tissue inhibitor of metalloproteinase 2
chr19_-_47464406 0.248 ENSMUST00000111800.2
ENSMUST00000081619.2
Sh3pxd2a

SH3 and PX domains 2A

chr14_+_32085804 0.235 ENSMUST00000170600.1
ENSMUST00000168986.1
ENSMUST00000169649.1
Oxnad1


oxidoreductase NAD-binding domain containing 1


chr14_-_36919513 0.224 ENSMUST00000182042.1
Ccser2
coiled-coil serine rich 2
chr3_+_103575275 0.222 ENSMUST00000090697.4
Syt6
synaptotagmin VI
chr4_+_31964081 0.195 ENSMUST00000037607.4
ENSMUST00000080933.6
ENSMUST00000108183.1
ENSMUST00000108184.2
Map3k7



mitogen-activated protein kinase kinase kinase 7



chr5_-_74531619 0.191 ENSMUST00000113542.2
ENSMUST00000072857.6
ENSMUST00000121330.1
ENSMUST00000151474.1
Scfd2



Sec1 family domain containing 2



chr12_+_55836365 0.181 ENSMUST00000059250.6
Brms1l
breast cancer metastasis-suppressor 1-like
chr7_+_81213567 0.133 ENSMUST00000026672.7
Pde8a
phosphodiesterase 8A
chr1_-_63176653 0.119 ENSMUST00000027111.8
ENSMUST00000168099.2
Ndufs1

NADH dehydrogenase (ubiquinone) Fe-S protein 1

chr13_-_18382041 0.118 ENSMUST00000139064.2
ENSMUST00000175703.2
Pou6f2

POU domain, class 6, transcription factor 2

chrX_-_143933089 0.110 ENSMUST00000087313.3
Dcx
doublecortin
chrX_+_56779437 0.081 ENSMUST00000114773.3
Fhl1
four and a half LIM domains 1
chrX_+_140456613 0.076 ENSMUST00000033809.3
Prps1
phosphoribosyl pyrophosphate synthetase 1
chr18_-_15063560 0.068 ENSMUST00000168989.1
Kctd1
potassium channel tetramerisation domain containing 1
chr4_-_92191749 0.033 ENSMUST00000123179.1
Gm12666
predicted gene 12666
chr18_-_20002093 0.022 ENSMUST00000115848.3
Dsc3
desmocollin 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
8.3 33.2 GO:0043490 malate-aspartate shuttle(GO:0043490)
3.0 33.2 GO:0042572 retinol metabolic process(GO:0042572)
1.9 5.7 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
1.6 12.8 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
1.5 5.8 GO:0021764 amygdala development(GO:0021764)
1.4 23.2 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
1.3 5.2 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
1.2 6.0 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
1.0 4.1 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.9 5.4 GO:0006570 tyrosine metabolic process(GO:0006570)
0.7 6.4 GO:0010908 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334)
0.6 2.5 GO:0035470 positive regulation of vascular wound healing(GO:0035470)
0.6 4.0 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.4 1.7 GO:0006526 arginine biosynthetic process(GO:0006526)
0.4 2.1 GO:0007262 STAT protein import into nucleus(GO:0007262)
0.3 1.2 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.3 0.6 GO:0060126 somatotropin secreting cell differentiation(GO:0060126)
0.3 0.9 GO:0036292 DNA rewinding(GO:0036292)
0.3 2.5 GO:0010459 negative regulation of heart rate(GO:0010459)
0.2 0.7 GO:0035878 nail development(GO:0035878)
0.2 8.9 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.2 4.0 GO:0035493 SNARE complex assembly(GO:0035493)
0.2 2.2 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.2 0.6 GO:0090327 negative regulation of locomotion involved in locomotory behavior(GO:0090327)
0.2 1.0 GO:0061042 vascular wound healing(GO:0061042)
0.2 0.9 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.2 2.3 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.2 5.9 GO:0046677 response to antibiotic(GO:0046677)
0.2 0.9 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.2 2.5 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.2 4.6 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.2 3.8 GO:0097150 neuronal stem cell population maintenance(GO:0097150)
0.1 1.7 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.1 2.0 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.1 1.3 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.1 1.1 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.1 2.3 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.1 0.7 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.1 0.4 GO:0002339 B cell selection(GO:0002339)
0.1 0.3 GO:0043654 recognition of apoptotic cell(GO:0043654)
0.1 0.6 GO:0090527 actin filament reorganization(GO:0090527)
0.1 0.5 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.2 GO:0072675 osteoclast fusion(GO:0072675)
0.0 0.3 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0 0.2 GO:0097343 ripoptosome assembly(GO:0097343) ripoptosome assembly involved in necroptotic process(GO:1901026)
0.0 0.3 GO:0035092 sperm chromatin condensation(GO:0035092)
0.0 4.8 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.0 0.5 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.0 4.3 GO:0030326 embryonic limb morphogenesis(GO:0030326) embryonic appendage morphogenesis(GO:0035113)
0.0 6.2 GO:0043524 negative regulation of neuron apoptotic process(GO:0043524)
0.0 3.0 GO:0014065 phosphatidylinositol 3-kinase signaling(GO:0014065)
0.0 0.1 GO:0046101 hypoxanthine metabolic process(GO:0046100) hypoxanthine biosynthetic process(GO:0046101)
0.0 0.5 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.1 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.0 3.4 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 2.8 GO:0022409 positive regulation of cell-cell adhesion(GO:0022409)
0.0 0.6 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.0 1.5 GO:0043488 regulation of mRNA stability(GO:0043488)
0.0 0.4 GO:0045471 response to ethanol(GO:0045471)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.7 GO:0005588 collagen type V trimer(GO:0005588)
1.7 5.2 GO:0072534 perineuronal net(GO:0072534)
0.8 4.0 GO:0070820 tertiary granule(GO:0070820)
0.7 6.4 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.3 12.8 GO:0016235 aggresome(GO:0016235)
0.2 5.4 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.2 20.4 GO:0000118 histone deacetylase complex(GO:0000118)
0.2 4.1 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.2 1.2 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.1 33.2 GO:0043197 dendritic spine(GO:0043197)
0.1 2.5 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 0.7 GO:0030056 hemidesmosome(GO:0030056)
0.1 0.4 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 0.4 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 2.5 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 3.8 GO:0016363 nuclear matrix(GO:0016363)
0.0 1.7 GO:0016459 myosin complex(GO:0016459)
0.0 0.5 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.7 GO:0031430 M band(GO:0031430)
0.0 3.8 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.9 GO:0043596 nuclear replication fork(GO:0043596)
0.0 1.2 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.9 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.1 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.0 0.3 GO:0001891 phagocytic cup(GO:0001891)
0.0 4.3 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 4.1 GO:0005667 transcription factor complex(GO:0005667)
0.0 1.4 GO:0005901 caveola(GO:0005901)
0.0 0.2 GO:0002102 podosome(GO:0002102)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
5.5 33.2 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
4.7 33.2 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.8 2.5 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.6 2.5 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.6 2.8 GO:0038132 neuregulin binding(GO:0038132)
0.5 3.0 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.4 1.7 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.4 5.4 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.4 1.2 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.3 5.2 GO:0046625 sphingolipid binding(GO:0046625)
0.2 5.2 GO:0045295 gamma-catenin binding(GO:0045295)
0.2 1.0 GO:0097003 adipokinetic hormone receptor activity(GO:0097003)
0.2 6.7 GO:0071837 HMG box domain binding(GO:0071837)
0.2 21.3 GO:0046332 SMAD binding(GO:0046332)
0.2 4.0 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.2 2.3 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 2.3 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 6.4 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 4.8 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.1 4.6 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 5.8 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.1 4.0 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 2.2 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 0.9 GO:0036310 annealing helicase activity(GO:0036310)
0.1 3.5 GO:0030507 spectrin binding(GO:0030507)
0.1 0.9 GO:0046527 glucosyltransferase activity(GO:0046527)
0.0 0.9 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.4 GO:1990405 protein antigen binding(GO:1990405)
0.0 0.2 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 6.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 1.7 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 3.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.4 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 18.5 GO:0003682 chromatin binding(GO:0003682)
0.0 0.6 GO:0031690 adrenergic receptor binding(GO:0031690)
0.0 0.5 GO:0031402 sodium ion binding(GO:0031402)
0.0 0.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 8.6 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0 1.5 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.1 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.0 1.3 GO:0035257 nuclear hormone receptor binding(GO:0035257)
0.0 0.4 GO:0003746 translation elongation factor activity(GO:0003746)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 30.5 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.2 2.5 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.2 9.3 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.2 2.1 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 6.4 PID_ARF6_PATHWAY Arf6 signaling events
0.1 5.7 NABA_COLLAGENS Genes encoding collagen proteins
0.1 2.5 PID_IL5_PATHWAY IL5-mediated signaling events
0.1 4.6 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 6.3 PID_AP1_PATHWAY AP-1 transcription factor network
0.1 0.7 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 3.0 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 3.5 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 2.9 PID_CDC42_PATHWAY CDC42 signaling events
0.0 5.2 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.0 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 1.7 ST_FAS_SIGNALING_PATHWAY Fas Signaling Pathway
0.0 1.3 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.2 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 33.2 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.3 4.0 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.2 4.1 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.2 2.5 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.2 2.5 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.2 8.1 REACTOME_RNA_POL_III_TRANSCRIPTION Genes involved in RNA Polymerase III Transcription
0.1 5.7 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 7.0 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 2.1 REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.1 1.7 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.1 2.2 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.1 9.5 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 2.0 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 1.1 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 2.0 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 0.2 REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.3 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix