Motif ID: Six3_Six1_Six2

Z-value: 0.880

Transcription factors associated with Six3_Six1_Six2:

Gene SymbolEntrez IDGene Name
Six1 ENSMUSG00000051367.8 Six1
Six2 ENSMUSG00000024134.10 Six2
Six3 ENSMUSG00000038805.9 Six3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Six2mm10_v2_chr17_-_85688252_856882750.471.9e-03Click!
Six3mm10_v2_chr17_+_85620816_856208430.391.2e-02Click!
Six1mm10_v2_chr12_-_73047179_730471790.305.6e-02Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Six3_Six1_Six2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_98422961 6.316 ENSMUST00000052068.9
Rbp1
retinol binding protein 1, cellular
chrX_-_142966709 6.121 ENSMUST00000041317.2
Ammecr1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr5_+_140607334 4.949 ENSMUST00000031555.1
Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr15_+_98571004 4.937 ENSMUST00000023728.6
4930415O20Rik
RIKEN cDNA 4930415O20 gene
chr18_+_56432116 4.900 ENSMUST00000070166.5
Gramd3
GRAM domain containing 3
chr15_-_75894474 4.685 ENSMUST00000023237.6
Naprt1
nicotinate phosphoribosyltransferase domain containing 1
chr2_+_106693185 4.445 ENSMUST00000111063.1
Mpped2
metallophosphoesterase domain containing 2
chr15_-_82244716 4.032 ENSMUST00000089155.4
ENSMUST00000089157.3
Cenpm

centromere protein M

chr1_+_139454747 3.456 ENSMUST00000053364.8
ENSMUST00000097554.3
Aspm

asp (abnormal spindle)-like, microcephaly associated (Drosophila)

chr3_+_130068390 2.916 ENSMUST00000076703.6
Gm9396
predicted gene 9396
chr7_-_80115294 2.740 ENSMUST00000107384.3
Idh2
isocitrate dehydrogenase 2 (NADP+), mitochondrial
chr5_+_139423151 2.485 ENSMUST00000066211.4
Gper1
G protein-coupled estrogen receptor 1
chr3_-_85722474 2.215 ENSMUST00000119077.1
Fam160a1
family with sequence similarity 160, member A1
chr7_+_30231884 2.074 ENSMUST00000019882.9
Polr2i
polymerase (RNA) II (DNA directed) polypeptide I
chr13_+_94083490 2.056 ENSMUST00000156071.1
Lhfpl2
lipoma HMGIC fusion partner-like 2
chr8_-_4275886 1.897 ENSMUST00000003029.7
Timm44
translocase of inner mitochondrial membrane 44
chr10_+_24595623 1.691 ENSMUST00000176228.1
ENSMUST00000129142.1
Ctgf

connective tissue growth factor

chr8_+_57455898 1.548 ENSMUST00000034023.3
Scrg1
scrapie responsive gene 1
chr7_+_30232310 1.509 ENSMUST00000108193.1
ENSMUST00000108192.1
Polr2i

polymerase (RNA) II (DNA directed) polypeptide I

chr7_-_126676357 1.394 ENSMUST00000106371.1
ENSMUST00000106372.3
ENSMUST00000155419.1
Sult1a1


sulfotransferase family 1A, phenol-preferring, member 1


chr3_-_37724321 1.337 ENSMUST00000108105.1
ENSMUST00000079755.4
ENSMUST00000099128.1
Gm5148


predicted gene 5148


chr14_+_57798182 1.317 ENSMUST00000111269.1
Sap18
Sin3-associated polypeptide 18
chr17_+_35241838 1.291 ENSMUST00000173731.1
Ddx39b
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chrX_-_74373260 1.288 ENSMUST00000073067.4
ENSMUST00000037967.5
Slc10a3

solute carrier family 10 (sodium/bile acid cotransporter family), member 3

chr3_+_94398517 1.233 ENSMUST00000050975.3
Lingo4
leucine rich repeat and Ig domain containing 4
chr7_-_126676428 1.206 ENSMUST00000106373.1
Sult1a1
sulfotransferase family 1A, phenol-preferring, member 1
chr17_+_35241746 1.069 ENSMUST00000068056.5
ENSMUST00000174757.1
Ddx39b

DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B

chr10_+_100488289 1.037 ENSMUST00000164751.1
Cep290
centrosomal protein 290
chrX_+_169685191 1.012 ENSMUST00000112104.1
ENSMUST00000112107.1
Mid1

midline 1

chr8_-_106573461 0.989 ENSMUST00000073722.5
Gm10073
predicted pseudogene 10073
chr13_+_104229366 0.955 ENSMUST00000022227.6
Cenpk
centromere protein K
chr9_+_104002546 0.949 ENSMUST00000035167.8
ENSMUST00000117054.1
Nphp3

nephronophthisis 3 (adolescent)

chr6_+_38534823 0.779 ENSMUST00000019833.4
1110001J03Rik
RIKEN cDNA 1110001J03 gene
chr3_+_88207308 0.758 ENSMUST00000180582.1
Gm3764
predicted gene 3764
chr9_+_72958785 0.696 ENSMUST00000098567.2
ENSMUST00000034734.8
Dyx1c1

dyslexia susceptibility 1 candidate 1 homolog (human)

chr4_-_43030440 0.627 ENSMUST00000135660.1
Stoml2
stomatin (Epb7.2)-like 2
chrX_-_74373218 0.601 ENSMUST00000178691.1
ENSMUST00000114146.1
Ubl4
Slc10a3
ubiquitin-like 4
solute carrier family 10 (sodium/bile acid cotransporter family), member 3
chr2_+_127336152 0.576 ENSMUST00000028846.6
Dusp2
dual specificity phosphatase 2
chr7_-_141168671 0.536 ENSMUST00000106033.3
Rnh1
ribonuclease/angiogenin inhibitor 1
chr13_+_43785107 0.513 ENSMUST00000015540.2
Cd83
CD83 antigen
chr5_+_21543525 0.489 ENSMUST00000035651.4
Lrrc17
leucine rich repeat containing 17
chr4_-_32950813 0.483 ENSMUST00000084750.1
ENSMUST00000084748.2
Ankrd6

ankyrin repeat domain 6

chr8_+_69832633 0.482 ENSMUST00000131637.2
ENSMUST00000081503.6
Pbx4

pre B cell leukemia homeobox 4

chr2_+_131491764 0.460 ENSMUST00000028806.5
ENSMUST00000110179.2
ENSMUST00000110189.2
ENSMUST00000110182.2
ENSMUST00000110183.2
ENSMUST00000110186.2
ENSMUST00000110188.1
Smox






spermine oxidase






chr14_+_57798156 0.459 ENSMUST00000128764.1
Sap18
Sin3-associated polypeptide 18
chr11_-_69695521 0.451 ENSMUST00000181261.1
Tnfsf12
tumor necrosis factor (ligand) superfamily, member 12
chr1_+_136467958 0.419 ENSMUST00000047817.6
Kif14
kinesin family member 14
chr9_+_65141154 0.394 ENSMUST00000034961.4
Igdcc3
immunoglobulin superfamily, DCC subclass, member 3
chr15_-_76206309 0.389 ENSMUST00000073418.6
ENSMUST00000171634.1
ENSMUST00000076442.5
Plec


plectin


chr7_+_43690418 0.375 ENSMUST00000056329.6
Klk14
kallikrein related-peptidase 14
chr12_+_30584429 0.360 ENSMUST00000057151.8
Tmem18
transmembrane protein 18
chr19_-_55315980 0.355 ENSMUST00000076891.5
Zdhhc6
zinc finger, DHHC domain containing 6
chr12_+_84773262 0.332 ENSMUST00000021667.5
Isca2
iron-sulfur cluster assembly 2 homolog (S. cerevisiae)
chr4_+_11758147 0.300 ENSMUST00000029871.5
ENSMUST00000108303.1
Cdh17

cadherin 17

chr5_+_104046869 0.279 ENSMUST00000031250.7
Nudt9
nudix (nucleoside diphosphate linked moiety X)-type motif 9
chr17_-_56716788 0.256 ENSMUST00000067931.5
Vmac
vimentin-type intermediate filament associated coiled-coil protein
chr17_+_40811089 0.252 ENSMUST00000024721.7
Rhag
Rhesus blood group-associated A glycoprotein
chr11_-_101987004 0.240 ENSMUST00000107173.2
ENSMUST00000107172.1
Dusp3

dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)

chr16_-_11203259 0.186 ENSMUST00000119953.1
Rsl1d1
ribosomal L1 domain containing 1
chr10_-_128180265 0.182 ENSMUST00000099139.1
Rbms2
RNA binding motif, single stranded interacting protein 2
chr2_-_13271419 0.147 ENSMUST00000028059.2
Rsu1
Ras suppressor protein 1
chr14_+_58893465 0.132 ENSMUST00000079960.1
Rpl13-ps3
ribosomal protein L13, pseudogene 3
chr17_-_53539411 0.130 ENSMUST00000056198.3
Pp2d1
protein phosphatase 2C-like domain containing 1
chr7_-_101903783 0.130 ENSMUST00000106969.1
Tomt
transmembrane O-methyltransferase
chr5_-_62765618 0.114 ENSMUST00000159470.1
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr4_+_133176336 0.108 ENSMUST00000105912.1
Wasf2
WAS protein family, member 2
chrY_-_6237995 0.107 ENSMUST00000177612.1
Gm21746
predicted gene, 21746
chr2_-_13271268 0.103 ENSMUST00000137670.1
ENSMUST00000114791.2
Rsu1

Ras suppressor protein 1

chr3_+_146220955 0.098 ENSMUST00000039164.2
Lpar3
lysophosphatidic acid receptor 3
chr17_+_56717759 0.098 ENSMUST00000002452.6
Ndufa11
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 11
chr8_+_84831522 0.082 ENSMUST00000036734.5
Gadd45gip1
growth arrest and DNA-damage-inducible, gamma interacting protein 1
chr16_+_11203375 0.082 ENSMUST00000181526.1
2610020C07Rik
RIKEN cDNA 2610020C07 gene
chr16_-_18235074 0.079 ENSMUST00000076957.5
Zdhhc8
zinc finger, DHHC domain containing 8
chr2_+_158028481 0.076 ENSMUST00000103123.3
Rprd1b
regulation of nuclear pre-mRNA domain containing 1B
chr5_-_106926245 0.073 ENSMUST00000117588.1
Hfm1
HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)
chr9_+_119341487 0.051 ENSMUST00000175743.1
ENSMUST00000176397.1
Acaa1a

acetyl-Coenzyme A acyltransferase 1A

chr13_-_74292297 0.044 ENSMUST00000109640.1
ENSMUST00000022059.7
Ahrr

aryl-hydrocarbon receptor repressor

chr17_-_36951636 0.038 ENSMUST00000040402.7
ENSMUST00000174711.1
Ppp1r11

protein phosphatase 1, regulatory (inhibitor) subunit 11


Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 6.3 GO:0006776 vitamin A metabolic process(GO:0006776)
1.2 3.6 GO:0001193 maintenance of transcriptional fidelity during DNA-templated transcription elongation(GO:0001192) maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter(GO:0001193)
1.0 4.9 GO:0007386 compartment pattern specification(GO:0007386)
0.9 2.7 GO:0006097 glyoxylate cycle(GO:0006097) negative regulation of glial cell migration(GO:1903976)
0.7 3.5 GO:0051661 maintenance of centrosome location(GO:0051661)
0.6 2.5 GO:1904706 regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579) negative regulation of vascular smooth muscle cell proliferation(GO:1904706) positive regulation of vascular smooth muscle cell differentiation(GO:1905065)
0.4 1.7 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.3 2.4 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.3 0.9 GO:0048496 maintenance of organ identity(GO:0048496)
0.2 2.6 GO:0051923 sulfation(GO:0051923)
0.2 0.6 GO:1990046 positive regulation of mitochondrial DNA replication(GO:0090297) regulation of cardiolipin metabolic process(GO:1900208) positive regulation of cardiolipin metabolic process(GO:1900210) stress-induced mitochondrial fusion(GO:1990046)
0.1 0.4 GO:0021698 cerebellar cortex structural organization(GO:0021698)
0.1 1.9 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 1.0 GO:0035372 protein localization to microtubule(GO:0035372)
0.1 0.3 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.1 0.5 GO:0048539 bone marrow development(GO:0048539)
0.1 0.4 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 0.3 GO:0046032 ADP catabolic process(GO:0046032)
0.1 0.5 GO:0046208 spermine catabolic process(GO:0046208)
0.1 0.5 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)
0.1 0.7 GO:0036159 outer dynein arm assembly(GO:0036158) inner dynein arm assembly(GO:0036159)
0.1 0.4 GO:0007320 insemination(GO:0007320)
0.0 0.3 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.3 GO:0015670 carbon dioxide transport(GO:0015670)
0.0 0.5 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 0.1 GO:0019614 catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
0.0 1.9 GO:0032526 response to retinoic acid(GO:0032526)
0.0 0.6 GO:0001706 endoderm formation(GO:0001706)
0.0 0.6 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.0 0.2 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.4 GO:0018345 protein palmitoylation(GO:0018345)
0.0 1.2 GO:0051965 positive regulation of synapse assembly(GO:0051965)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 3.5 GO:0036449 microtubule minus-end(GO:0036449)
0.3 0.9 GO:0097543 ciliary inversin compartment(GO:0097543)
0.2 2.5 GO:0032591 dendritic spine membrane(GO:0032591)
0.2 2.4 GO:0005688 U6 snRNP(GO:0005688)
0.2 1.8 GO:0061574 ASAP complex(GO:0061574)
0.2 3.6 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.2 0.5 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.1 4.9 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 5.9 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 1.0 GO:0036038 MKS complex(GO:0036038)
0.0 0.6 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.4 GO:0030056 hemidesmosome(GO:0030056)
0.0 1.7 GO:0005801 cis-Golgi network(GO:0005801)
0.0 5.0 GO:0000776 kinetochore(GO:0000776)
0.0 0.5 GO:0001741 XY body(GO:0001741)
0.0 0.4 GO:0051233 spindle midzone(GO:0051233)
0.0 2.8 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 1.5 GO:0044306 neuron projection terminus(GO:0044306)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.9 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
1.1 6.3 GO:0019841 retinol binding(GO:0019841)
0.9 2.7 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.9 2.6 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.5 2.4 GO:0030621 U4 snRNA binding(GO:0030621)
0.5 1.9 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.4 2.5 GO:0030284 estrogen receptor activity(GO:0030284)
0.2 0.5 GO:0046592 polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)
0.1 0.3 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.1 0.6 GO:1901612 phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)
0.1 3.6 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.1 1.7 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 0.5 GO:0008428 ribonuclease inhibitor activity(GO:0008428)
0.0 0.8 GO:0033549 MAP kinase phosphatase activity(GO:0033549)
0.0 0.1 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.0 0.3 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.0 0.6 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.5 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 1.9 GO:0051087 chaperone binding(GO:0051087)
0.0 3.5 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.4 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.1 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.7 GO:0030331 estrogen receptor binding(GO:0030331)
0.0 0.4 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.1 GO:0008410 CoA-transferase activity(GO:0008410)
0.0 0.3 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 6.3 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 1.7 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.0 1.7 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.5 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.6 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.2 4.9 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.2 3.6 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.1 2.7 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 1.7 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 5.0 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 1.9 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.5 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.2 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.0 0.4 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 1.0 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.3 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters