Motif ID: Pbx2
Z-value: 0.639

Transcription factors associated with Pbx2:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Pbx2 | ENSMUSG00000034673.8 | Pbx2 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Pbx2 | mm10_v2_chr17_+_34593388_34593417 | -0.55 | 2.0e-04 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 2.3 | GO:0043553 | negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) |
0.2 | 1.2 | GO:1902998 | macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
0.1 | 0.6 | GO:0006547 | histidine metabolic process(GO:0006547) |
0.1 | 2.3 | GO:0021902 | commitment of neuronal cell to specific neuron type in forebrain(GO:0021902) |
0.1 | 1.0 | GO:0045743 | positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743) |
0.1 | 0.3 | GO:1903225 | negative regulation of endodermal cell differentiation(GO:1903225) |
0.1 | 4.1 | GO:0000038 | very long-chain fatty acid metabolic process(GO:0000038) |
0.1 | 1.0 | GO:0016127 | cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127) |
0.1 | 1.3 | GO:0009312 | oligosaccharide biosynthetic process(GO:0009312) |
0.1 | 1.7 | GO:0032291 | central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291) |
0.1 | 0.3 | GO:0002188 | translation reinitiation(GO:0002188) |
0.1 | 0.5 | GO:0006561 | proline biosynthetic process(GO:0006561) |
0.1 | 0.4 | GO:0060164 | regulation of timing of neuron differentiation(GO:0060164) |
0.1 | 0.2 | GO:0006049 | UDP-N-acetylglucosamine catabolic process(GO:0006049) |
0.1 | 1.0 | GO:0001553 | luteinization(GO:0001553) |
0.1 | 1.4 | GO:0006298 | mismatch repair(GO:0006298) |
0.1 | 3.8 | GO:0038083 | peptidyl-tyrosine autophosphorylation(GO:0038083) |
0.0 | 0.2 | GO:0072235 | distal convoluted tubule development(GO:0072025) metanephric distal convoluted tubule development(GO:0072221) metanephric distal tubule development(GO:0072235) |
0.0 | 0.2 | GO:0016340 | calcium-dependent cell-matrix adhesion(GO:0016340) |
0.0 | 0.1 | GO:0046618 | drug export(GO:0046618) |
0.0 | 0.2 | GO:0017121 | phospholipid scrambling(GO:0017121) |
0.0 | 0.3 | GO:1901096 | regulation of autophagosome maturation(GO:1901096) |
0.0 | 0.1 | GO:0002678 | positive regulation of chronic inflammatory response(GO:0002678) |
0.0 | 0.1 | GO:0042780 | tRNA 3'-end processing(GO:0042780) |
0.0 | 0.3 | GO:0033689 | negative regulation of osteoblast proliferation(GO:0033689) |
0.0 | 0.2 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
0.0 | 0.1 | GO:0046013 | regulation of T cell homeostatic proliferation(GO:0046013) negative regulation of T-helper 17 type immune response(GO:2000317) regulation of T-helper 17 cell differentiation(GO:2000319) negative regulation of T-helper 17 cell differentiation(GO:2000320) |
0.0 | 0.0 | GO:0035963 | response to interleukin-13(GO:0035962) cellular response to interleukin-13(GO:0035963) |
0.0 | 0.1 | GO:0034773 | histone H4-K20 trimethylation(GO:0034773) establishment of Sertoli cell barrier(GO:0097368) |
0.0 | 2.1 | GO:0010811 | positive regulation of cell-substrate adhesion(GO:0010811) |
0.0 | 0.2 | GO:0006098 | pentose-phosphate shunt(GO:0006098) |
0.0 | 0.1 | GO:0014816 | skeletal muscle satellite cell differentiation(GO:0014816) |
0.0 | 0.6 | GO:0007212 | dopamine receptor signaling pathway(GO:0007212) |
0.0 | 1.1 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
0.0 | 0.2 | GO:0046069 | cGMP catabolic process(GO:0046069) |
0.0 | 0.5 | GO:0010972 | negative regulation of G2/M transition of mitotic cell cycle(GO:0010972) |
0.0 | 0.1 | GO:0001731 | formation of translation preinitiation complex(GO:0001731) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 1.2 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
0.1 | 2.2 | GO:0005614 | interstitial matrix(GO:0005614) |
0.1 | 2.9 | GO:0005682 | U5 snRNP(GO:0005682) |
0.1 | 0.3 | GO:0005588 | collagen type V trimer(GO:0005588) |
0.1 | 0.9 | GO:0033269 | internode region of axon(GO:0033269) |
0.1 | 1.6 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
0.0 | 0.7 | GO:0030126 | COPI vesicle coat(GO:0030126) |
0.0 | 4.4 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
0.0 | 0.2 | GO:0016011 | dystroglycan complex(GO:0016011) |
0.0 | 4.1 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
0.0 | 2.1 | GO:0000118 | histone deacetylase complex(GO:0000118) |
0.0 | 2.3 | GO:0031225 | anchored component of membrane(GO:0031225) |
0.0 | 0.1 | GO:0046581 | intercellular canaliculus(GO:0046581) |
0.0 | 0.1 | GO:0002177 | manchette(GO:0002177) |
0.0 | 0.1 | GO:0045298 | tubulin complex(GO:0045298) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.8 | 2.3 | GO:0036313 | phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313) |
0.4 | 4.0 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
0.2 | 0.6 | GO:0004487 | methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487) |
0.2 | 1.3 | GO:0001665 | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665) |
0.1 | 0.5 | GO:0004735 | pyrroline-5-carboxylate reductase activity(GO:0004735) |
0.1 | 0.6 | GO:0051429 | corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430) |
0.1 | 3.2 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
0.1 | 0.2 | GO:0017057 | 6-phosphogluconolactonase activity(GO:0017057) |
0.1 | 0.2 | GO:0003996 | acyl-CoA ligase activity(GO:0003996) fatty-acyl-CoA synthase activity(GO:0004321) |
0.1 | 0.2 | GO:0003827 | alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827) |
0.1 | 1.2 | GO:0051787 | misfolded protein binding(GO:0051787) |
0.0 | 1.0 | GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) |
0.0 | 0.3 | GO:0017040 | ceramidase activity(GO:0017040) |
0.0 | 1.1 | GO:0017134 | fibroblast growth factor binding(GO:0017134) |
0.0 | 0.2 | GO:0004984 | olfactory receptor activity(GO:0004984) |
0.0 | 0.4 | GO:0098505 | G-rich strand telomeric DNA binding(GO:0098505) |
0.0 | 0.2 | GO:0004118 | cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) |
0.0 | 0.1 | GO:0008559 | xenobiotic-transporting ATPase activity(GO:0008559) phosphatidylcholine-translocating ATPase activity(GO:0090554) |
0.0 | 0.8 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
0.0 | 0.1 | GO:0004322 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
0.0 | 0.9 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
0.0 | 0.1 | GO:0043208 | glycosphingolipid binding(GO:0043208) |
0.0 | 0.1 | GO:0008410 | CoA-transferase activity(GO:0008410) |
0.0 | 0.3 | GO:0008484 | sulfuric ester hydrolase activity(GO:0008484) |
0.0 | 0.2 | GO:0043237 | laminin-1 binding(GO:0043237) |
0.0 | 1.1 | GO:0003684 | damaged DNA binding(GO:0003684) |
0.0 | 2.4 | GO:0005539 | glycosaminoglycan binding(GO:0005539) |
0.0 | 0.2 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
0.0 | 0.0 | GO:0047389 | glycerophosphocholine phosphodiesterase activity(GO:0047389) |
0.0 | 1.6 | GO:0030165 | PDZ domain binding(GO:0030165) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 0.6 | PID_S1P_S1P4_PATHWAY | S1P4 pathway |
0.0 | 0.2 | ST_PAC1_RECEPTOR_PATHWAY | PAC1 Receptor Pathway |
0.0 | 2.9 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
0.0 | 3.2 | PID_PDGFRB_PATHWAY | PDGFR-beta signaling pathway |
0.0 | 1.3 | PID_P75_NTR_PATHWAY | p75(NTR)-mediated signaling |
0.0 | 3.3 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 1.6 | REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
0.1 | 1.0 | REACTOME_ENDOGENOUS_STEROLS | Genes involved in Endogenous sterols |
0.0 | 1.0 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
0.0 | 1.1 | REACTOME_CELL_CELL_JUNCTION_ORGANIZATION | Genes involved in Cell-cell junction organization |
0.0 | 1.3 | REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
0.0 | 0.5 | REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
0.0 | 0.3 | REACTOME_CS_DS_DEGRADATION | Genes involved in CS/DS degradation |
0.0 | 0.6 | REACTOME_G_PROTEIN_ACTIVATION | Genes involved in G-protein activation |
0.0 | 2.5 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
0.0 | 1.2 | REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ | Genes involved in Response to elevated platelet cytosolic Ca2+ |
0.0 | 0.3 | REACTOME_CGMP_EFFECTS | Genes involved in cGMP effects |