Motif ID: Egr3

Z-value: 0.653


Transcription factors associated with Egr3:

Gene SymbolEntrez IDGene Name
Egr3 ENSMUSG00000033730.3 Egr3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Egr3mm10_v2_chr14_+_70077375_700774450.296.4e-02Click!


Activity profile for motif Egr3.

activity profile for motif Egr3


Sorted Z-values histogram for motif Egr3

Sorted Z-values for motif Egr3



Network of associatons between targets according to the STRING database.



First level regulatory network of Egr3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_119184374 3.314 ENSMUST00000084650.4
Gpr139
G protein-coupled receptor 139
chr7_-_110061319 2.845 ENSMUST00000098110.2
AA474408
expressed sequence AA474408
chr6_-_49214954 2.498 ENSMUST00000031838.7
Igf2bp3
insulin-like growth factor 2 mRNA binding protein 3
chr17_+_87282880 2.195 ENSMUST00000041110.5
ENSMUST00000125875.1
Ttc7

tetratricopeptide repeat domain 7

chr9_-_58204310 2.140 ENSMUST00000114144.2
Islr2
immunoglobulin superfamily containing leucine-rich repeat 2
chr8_+_62951361 2.013 ENSMUST00000119068.1
Spock3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3
chr17_-_87282793 1.964 ENSMUST00000146560.2
4833418N02Rik
RIKEN cDNA 4833418N02 gene
chr4_-_41695935 1.877 ENSMUST00000145379.1
Cntfr
ciliary neurotrophic factor receptor
chr17_-_87282771 1.876 ENSMUST00000161759.1
4833418N02Rik
RIKEN cDNA 4833418N02 gene
chr9_-_55048544 1.793 ENSMUST00000034854.6
Chrnb4
cholinergic receptor, nicotinic, beta polypeptide 4
chr11_+_98937669 1.641 ENSMUST00000107475.2
ENSMUST00000068133.3
Rara

retinoic acid receptor, alpha

chr7_-_144939823 1.612 ENSMUST00000093962.4
Ccnd1
cyclin D1
chr10_+_40883819 1.255 ENSMUST00000105509.1
Wasf1
WAS protein family, member 1
chr4_+_123183456 1.250 ENSMUST00000126995.1
Hpcal4
hippocalcin-like 4
chr4_+_123183722 1.230 ENSMUST00000152194.1
Hpcal4
hippocalcin-like 4
chr10_-_5922341 1.172 ENSMUST00000117676.1
ENSMUST00000019909.7
Rgs17

regulator of G-protein signaling 17

chrX_+_36195968 1.101 ENSMUST00000115256.1
Zcchc12
zinc finger, CCHC domain containing 12
chr1_-_156939387 1.060 ENSMUST00000171292.1
Ralgps2
Ral GEF with PH domain and SH3 binding motif 2
chr12_+_108635743 1.030 ENSMUST00000172409.1
Evl
Ena-vasodilator stimulated phosphoprotein
chrX_+_143664290 1.002 ENSMUST00000112868.1
Pak3
p21 protein (Cdc42/Rac)-activated kinase 3
chr11_-_109722214 0.970 ENSMUST00000020938.7
Fam20a
family with sequence similarity 20, member A
chr1_+_36068371 0.948 ENSMUST00000088174.3
Hs6st1
heparan sulfate 6-O-sulfotransferase 1
chr18_-_84086379 0.938 ENSMUST00000060303.8
Tshz1
teashirt zinc finger family member 1
chr10_+_40883469 0.905 ENSMUST00000019975.7
Wasf1
WAS protein family, member 1
chr2_+_32395896 0.903 ENSMUST00000028162.3
Ptges2
prostaglandin E synthase 2
chr19_+_6975048 0.867 ENSMUST00000070850.6
Ppp1r14b
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr10_-_5922385 0.852 ENSMUST00000131996.1
ENSMUST00000064225.7
Rgs17

regulator of G-protein signaling 17

chr3_+_135438722 0.819 ENSMUST00000166033.1
Ube2d3
ubiquitin-conjugating enzyme E2D 3
chr6_-_144209558 0.819 ENSMUST00000111749.1
ENSMUST00000170367.2
Sox5

SRY-box containing gene 5

chr10_+_69533761 0.802 ENSMUST00000182884.1
Ank3
ankyrin 3, epithelial
chrX_+_143664365 0.774 ENSMUST00000126592.1
ENSMUST00000156449.1
ENSMUST00000155215.1
ENSMUST00000112865.1
Pak3



p21 protein (Cdc42/Rac)-activated kinase 3



chr10_+_83722865 0.744 ENSMUST00000150459.1
1500009L16Rik
RIKEN cDNA 1500009L16 gene
chr5_-_138279960 0.679 ENSMUST00000014089.7
ENSMUST00000161827.1
Gpc2

glypican 2 (cerebroglycan)

chr10_+_69533803 0.669 ENSMUST00000182155.1
ENSMUST00000183169.1
ENSMUST00000183148.1
Ank3


ankyrin 3, epithelial


chrX_-_162159717 0.669 ENSMUST00000087085.3
Nhs
Nance-Horan syndrome (human)
chr10_-_18023229 0.634 ENSMUST00000020002.7
Abracl
ABRA C-terminal like
chr8_+_85026833 0.634 ENSMUST00000047281.8
2310036O22Rik
RIKEN cDNA 2310036O22 gene
chr5_+_77265454 0.608 ENSMUST00000080359.5
Rest
RE1-silencing transcription factor
chr2_+_3114220 0.601 ENSMUST00000072955.5
Fam171a1
family with sequence similarity 171, member A1
chr9_-_78481724 0.588 ENSMUST00000042235.8
Eef1a1
eukaryotic translation elongation factor 1 alpha 1
chr10_-_29144194 0.584 ENSMUST00000070359.2
Gm9996
predicted gene 9996
chr9_+_21616230 0.575 ENSMUST00000174008.1
Smarca4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
chr18_-_12305638 0.553 ENSMUST00000122408.1
ENSMUST00000118525.1
ENSMUST00000142066.1
Ankrd29


ankyrin repeat domain 29


chr7_+_4740111 0.549 ENSMUST00000098853.2
Suv420h2
suppressor of variegation 4-20 homolog 2 (Drosophila)
chr1_+_86526688 0.532 ENSMUST00000045897.8
Ptma
prothymosin alpha
chr7_+_4740178 0.527 ENSMUST00000108583.2
Suv420h2
suppressor of variegation 4-20 homolog 2 (Drosophila)
chr4_-_40948196 0.521 ENSMUST00000030125.4
ENSMUST00000108089.1
Bag1

BCL2-associated athanogene 1

chr9_+_21616166 0.512 ENSMUST00000034707.8
ENSMUST00000098948.3
Smarca4

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4

chr7_+_4740137 0.494 ENSMUST00000130215.1
ENSMUST00000108582.3
Suv420h2

suppressor of variegation 4-20 homolog 2 (Drosophila)

chr2_+_75659253 0.478 ENSMUST00000111964.1
ENSMUST00000111962.1
ENSMUST00000111961.1
ENSMUST00000164947.2
ENSMUST00000090792.4
Hnrnpa3




heterogeneous nuclear ribonucleoprotein A3




chr2_+_121413775 0.451 ENSMUST00000028683.7
Pdia3
protein disulfide isomerase associated 3
chr12_-_67221221 0.445 ENSMUST00000178814.1
ENSMUST00000179345.2
Mdga2
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
MAM domain-containing glycosylphosphatidylinositol anchor protein 2
chr3_+_105452326 0.427 ENSMUST00000098761.3
Kcnd3
potassium voltage-gated channel, Shal-related family, member 3
chr19_-_4615453 0.419 ENSMUST00000053597.2
Lrfn4
leucine rich repeat and fibronectin type III domain containing 4
chr2_-_65529275 0.406 ENSMUST00000126837.1
Scn3a
sodium channel, voltage-gated, type III, alpha
chr4_+_40948401 0.406 ENSMUST00000030128.5
Chmp5
charged multivesicular body protein 5
chr11_-_23895208 0.384 ENSMUST00000102863.2
ENSMUST00000020513.3
Papolg

poly(A) polymerase gamma

chr13_-_41847626 0.384 ENSMUST00000121404.1
Adtrp
androgen dependent TFPI regulating protein
chr10_+_69534208 0.382 ENSMUST00000182439.1
ENSMUST00000092434.5
ENSMUST00000092432.5
ENSMUST00000092431.5
ENSMUST00000054167.8
ENSMUST00000047061.6
Ank3





ankyrin 3, epithelial





chr11_-_98775333 0.376 ENSMUST00000064941.6
Nr1d1
nuclear receptor subfamily 1, group D, member 1
chr2_+_104590453 0.367 ENSMUST00000028599.7
Cstf3
cleavage stimulation factor, 3' pre-RNA, subunit 3
chrX_-_8252304 0.356 ENSMUST00000115594.1
Ftsj1
FtsJ homolog 1 (E. coli)
chr10_-_128645784 0.347 ENSMUST00000065334.3
Ikzf4
IKAROS family zinc finger 4
chr1_+_74236479 0.341 ENSMUST00000113820.2
ENSMUST00000006467.7
ENSMUST00000113819.1
Arpc2


actin related protein 2/3 complex, subunit 2


chr18_+_59062462 0.340 ENSMUST00000058633.2
ENSMUST00000175897.1
ENSMUST00000118510.1
ENSMUST00000175830.1
A730017C20Rik



RIKEN cDNA A730017C20 gene



chr3_-_127162328 0.339 ENSMUST00000182994.1
Ank2
ankyrin 2, brain
chr10_+_69534039 0.330 ENSMUST00000182557.1
Ank3
ankyrin 3, epithelial
chr5_-_149051604 0.330 ENSMUST00000093196.4
Hmgb1
high mobility group box 1
chrX_-_8252334 0.323 ENSMUST00000115595.1
ENSMUST00000033513.3
Ftsj1

FtsJ homolog 1 (E. coli)

chr7_+_126759601 0.319 ENSMUST00000050201.4
ENSMUST00000057669.9
Mapk3

mitogen-activated protein kinase 3

chr3_+_97901190 0.303 ENSMUST00000029476.2
ENSMUST00000122288.1
Sec22b

SEC22 vesicle trafficking protein homolog B (S. cerevisiae)

chr13_-_85288999 0.299 ENSMUST00000109552.2
Rasa1
RAS p21 protein activator 1
chr11_-_69981242 0.299 ENSMUST00000108594.1
Elp5
elongator acetyltransferase complex subunit 5
chr3_-_138131356 0.294 ENSMUST00000029805.8
Mttp
microsomal triglyceride transfer protein
chr4_+_57637816 0.289 ENSMUST00000150412.1
Gm20459
predicted gene 20459
chr13_+_59585259 0.279 ENSMUST00000168367.1
ENSMUST00000022038.7
ENSMUST00000166923.1
Naa35


N(alpha)-acetyltransferase 35, NatC auxiliary subunit


chr1_-_9299238 0.273 ENSMUST00000140295.1
Sntg1
syntrophin, gamma 1
chr7_+_80860909 0.258 ENSMUST00000132163.1
ENSMUST00000147125.1
Zscan2

zinc finger and SCAN domain containing 2

chr19_-_4615647 0.254 ENSMUST00000113822.2
Lrfn4
leucine rich repeat and fibronectin type III domain containing 4
chr13_-_107022027 0.234 ENSMUST00000117539.1
ENSMUST00000122233.1
ENSMUST00000022204.9
ENSMUST00000159772.1
Kif2a



kinesin family member 2A



chr19_+_16956110 0.231 ENSMUST00000087689.4
Prune2
prune homolog 2 (Drosophila)
chr9_-_75409951 0.191 ENSMUST00000049355.10
Mapk6
mitogen-activated protein kinase 6
chr7_-_100371889 0.170 ENSMUST00000032963.8
Ppme1
protein phosphatase methylesterase 1
chr13_-_41847482 0.170 ENSMUST00000072012.3
Adtrp
androgen dependent TFPI regulating protein
chr16_-_94370994 0.166 ENSMUST00000113914.1
ENSMUST00000113905.1
Pigp

phosphatidylinositol glycan anchor biosynthesis, class P

chr19_-_38224096 0.165 ENSMUST00000067167.5
Fra10ac1
FRA10AC1 homolog (human)
chr3_+_129213920 0.160 ENSMUST00000042587.10
Pitx2
paired-like homeodomain transcription factor 2
chr9_+_106203108 0.146 ENSMUST00000024047.5
Twf2
twinfilin, actin-binding protein, homolog 2 (Drosophila)
chr6_-_30896735 0.139 ENSMUST00000048774.6
ENSMUST00000166192.1
ENSMUST00000135230.1
Copg2


coatomer protein complex, subunit gamma 2


chr10_+_59221945 0.130 ENSMUST00000182161.1
Sowahc
sosondowah ankyrin repeat domain family member C
chr1_+_74506044 0.105 ENSMUST00000087215.5
Rqcd1
rcd1 (required for cell differentiation) homolog 1 (S. pombe)
chr19_-_6077183 0.102 ENSMUST00000025711.5
ENSMUST00000160590.1
Vps51

vacuolar protein sorting 51 homolog (S. cerevisiae)

chr7_+_3693602 0.082 ENSMUST00000123088.1
ENSMUST00000038521.7
ENSMUST00000108629.1
ENSMUST00000142713.1
Tsen34



tRNA splicing endonuclease 34 homolog (S. cerevisiae)



chr6_+_91684061 0.078 ENSMUST00000032185.7
Slc6a6
solute carrier family 6 (neurotransmitter transporter, taurine), member 6
chrX_-_48513518 0.073 ENSMUST00000114945.2
ENSMUST00000037349.7
Aifm1

apoptosis-inducing factor, mitochondrion-associated 1

chr11_-_33276334 0.060 ENSMUST00000183831.1
Gm12117
predicted gene 12117
chr5_-_137072254 0.059 ENSMUST00000077523.3
ENSMUST00000041388.4
Serpine1

serine (or cysteine) peptidase inhibitor, clade E, member 1

chr18_-_37935378 0.058 ENSMUST00000025337.7
Diap1
diaphanous homolog 1 (Drosophila)
chr8_+_104170513 0.055 ENSMUST00000171018.1
ENSMUST00000167633.1
ENSMUST00000093245.5
ENSMUST00000164076.1
Bean1



brain expressed, associated with Nedd4, 1



chr3_-_119783262 0.051 ENSMUST00000029780.7
Ptbp2
polypyrimidine tract binding protein 2
chr6_+_113307160 0.050 ENSMUST00000113122.1
ENSMUST00000113119.1
ENSMUST00000113121.1
ENSMUST00000113117.1
Brpf1



bromodomain and PHD finger containing, 1



chr5_+_143403819 0.048 ENSMUST00000110731.2
Kdelr2
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
chr18_-_37935429 0.048 ENSMUST00000115634.1
Diap1
diaphanous homolog 1 (Drosophila)
chr7_+_3645267 0.038 ENSMUST00000038913.9
Cnot3
CCR4-NOT transcription complex, subunit 3
chr2_-_148045891 0.031 ENSMUST00000109964.1
Foxa2
forkhead box A2
chr9_+_21546842 0.025 ENSMUST00000034703.8
ENSMUST00000115395.3
ENSMUST00000115394.1
Carm1


coactivator-associated arginine methyltransferase 1


chr2_-_173119402 0.005 ENSMUST00000094287.3
ENSMUST00000179693.1
Ctcfl

CCCTC-binding factor (zinc finger protein)-like


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0060084 synaptic transmission involved in micturition(GO:0060084)
0.5 1.6 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.5 1.9 GO:0003360 brainstem development(GO:0003360)
0.3 0.9 GO:0060023 soft palate development(GO:0060023)
0.3 2.2 GO:1990416 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.2 1.6 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.2 2.0 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.2 1.1 GO:2000325 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.2 1.1 GO:0007403 glial cell fate determination(GO:0007403)
0.2 1.1 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)
0.2 2.2 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.2 1.0 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.2 1.0 GO:0070166 enamel mineralization(GO:0070166)
0.2 0.9 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.2 0.6 GO:2000705 regulation of dense core granule biogenesis(GO:2000705)
0.2 0.5 GO:1903334 positive regulation of protein folding(GO:1903334)
0.1 0.4 GO:0061763 multivesicular body-lysosome fusion(GO:0061763)
0.1 0.4 GO:0010871 negative regulation of receptor biosynthetic process(GO:0010871)
0.1 0.3 GO:2000812 response to rapamycin(GO:1901355) regulation of barbed-end actin filament capping(GO:2000812)
0.1 0.3 GO:0045819 plasmacytoid dendritic cell activation(GO:0002270) positive regulation of glycogen catabolic process(GO:0045819)
0.1 0.8 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.1 0.5 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.1 0.4 GO:0046684 response to pyrethroid(GO:0046684)
0.1 1.8 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.1 0.3 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.1 0.3 GO:0000189 MAPK import into nucleus(GO:0000189)
0.1 3.3 GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway(GO:0007200)
0.0 2.2 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.0 0.4 GO:0097623 potassium ion export across plasma membrane(GO:0097623)
0.0 0.9 GO:0001516 prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457)
0.0 0.2 GO:0060578 extraocular skeletal muscle development(GO:0002074) subthalamic nucleus development(GO:0021763) left lung morphogenesis(GO:0060460) pulmonary vein morphogenesis(GO:0060577) superior vena cava morphogenesis(GO:0060578)
0.0 0.3 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.0 2.3 GO:0045773 positive regulation of axon extension(GO:0045773)
0.0 0.8 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.9 GO:0071364 response to epidermal growth factor(GO:0070849) cellular response to epidermal growth factor stimulus(GO:0071364)
0.0 0.3 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280) negative regulation of autophagosome assembly(GO:1902902)
0.0 0.5 GO:0043486 histone exchange(GO:0043486)
0.0 3.0 GO:0051028 mRNA transport(GO:0051028)
0.0 0.7 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.1 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.0 0.1 GO:0010757 arachidonic acid metabolite production involved in inflammatory response(GO:0002538) negative regulation of plasminogen activation(GO:0010757) regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.0 0.3 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.0 0.4 GO:0006378 mRNA polyadenylation(GO:0006378)
0.0 0.4 GO:0006379 mRNA cleavage(GO:0006379)
0.0 0.0 GO:0045014 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) detection of glucose(GO:0051594)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.2 2.2 GO:0031209 SCAR complex(GO:0031209)
0.2 1.8 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.2 1.1 GO:0005726 perichromatin fibrils(GO:0005726)
0.1 2.2 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 0.3 GO:0031417 NatC complex(GO:0031417)
0.1 0.5 GO:0042825 TAP complex(GO:0042825)
0.0 0.3 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0 0.3 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.4 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 1.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.5 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.1 GO:1990745 EARP complex(GO:1990745)
0.0 0.3 GO:0031143 pseudopodium(GO:0031143)
0.0 0.3 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.4 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.3 GO:0031430 M band(GO:0031430)
0.0 0.3 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.1 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.0 0.1 GO:0042583 chromaffin granule(GO:0042583)
0.0 0.2 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.2 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.2 GO:0032156 septin cytoskeleton(GO:0032156)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.9 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.2 0.9 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.2 0.9 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.2 1.8 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.2 2.0 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.2 3.3 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.2 0.5 GO:0019153 protein-disulfide reductase (glutathione) activity(GO:0019153)
0.1 4.1 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.1 0.5 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.1 0.3 GO:0000402 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)
0.1 2.1 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 0.4 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250) voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.1 1.0 GO:0005522 profilin binding(GO:0005522)
0.1 0.6 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.1 1.1 GO:0001163 RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.1 0.7 GO:0016427 tRNA (cytosine) methyltransferase activity(GO:0016427)
0.1 1.6 GO:0070064 proline-rich region binding(GO:0070064)
0.1 0.4 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.1 2.5 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 2.5 GO:0030507 spectrin binding(GO:0030507)
0.0 1.0 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 2.2 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 0.7 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.6 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.1 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 0.4 GO:0031402 sodium ion binding(GO:0031402)
0.0 0.9 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 1.1 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.3 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.8 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.4 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 0.3 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.2 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.1 GO:0000213 tRNA-intron endonuclease activity(GO:0000213) endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.0 0.0 GO:0010484 H3 histone acetyltransferase activity(GO:0010484)
0.0 0.0 GO:0046923 ER retention sequence binding(GO:0046923)
0.0 0.2 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.3 GO:0034185 apolipoprotein binding(GO:0034185)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 3.9 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.1 1.1 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.1 2.0 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.6 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.8 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 1.2 PID_IFNG_PATHWAY IFN-gamma pathway
0.0 0.4 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.3 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.9 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 0.3 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.0 1.1 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.8 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 2.2 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 1.6 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 1.0 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.6 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 1.6 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.5 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.8 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 2.0 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.0 0.3 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.4 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 2.5 REACTOME_DIABETES_PATHWAYS Genes involved in Diabetes pathways
0.0 0.4 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 1.0 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway