Motif ID: Rara

Z-value: 0.667


Transcription factors associated with Rara:

Gene SymbolEntrez IDGene Name
Rara ENSMUSG00000037992.10 Rara

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Raramm10_v2_chr11_+_98927785_989278180.481.5e-03Click!


Activity profile for motif Rara.

activity profile for motif Rara


Sorted Z-values histogram for motif Rara

Sorted Z-values for motif Rara



Network of associatons between targets according to the STRING database.



First level regulatory network of Rara

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_+_94875600 4.662 ENSMUST00000022195.10
Otp
orthopedia homolog (Drosophila)
chr11_+_98960412 3.838 ENSMUST00000107473.2
Rara
retinoic acid receptor, alpha
chr4_-_141599835 3.485 ENSMUST00000141518.1
ENSMUST00000127455.1
ENSMUST00000105784.1
ENSMUST00000147785.1
Fblim1



filamin binding LIM protein 1



chr2_+_169633517 3.079 ENSMUST00000109157.1
Tshz2
teashirt zinc finger family member 2
chr3_-_54915867 2.582 ENSMUST00000070342.3
Sertm1
serine rich and transmembrane domain containing 1
chr12_+_87026564 1.656 ENSMUST00000110187.1
ENSMUST00000156162.1
Tmem63c

transmembrane protein 63c

chr1_-_175692624 1.462 ENSMUST00000027809.7
Opn3
opsin 3
chr17_+_34593388 1.454 ENSMUST00000174532.1
Pbx2
pre B cell leukemia homeobox 2
chr4_+_150853919 1.439 ENSMUST00000073600.2
Errfi1
ERBB receptor feedback inhibitor 1
chr17_-_56133817 1.433 ENSMUST00000167545.1
Sema6b
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
chr4_+_32238950 1.401 ENSMUST00000037416.6
Bach2
BTB and CNC homology 2
chr4_-_46991842 1.279 ENSMUST00000107749.2
Gabbr2
gamma-aminobutyric acid (GABA) B receptor, 2
chr6_+_91157373 1.238 ENSMUST00000155007.1
Hdac11
histone deacetylase 11
chr14_-_16575456 1.131 ENSMUST00000063750.6
Rarb
retinoic acid receptor, beta
chr5_+_135806859 1.048 ENSMUST00000126232.1
Srrm3
serine/arginine repetitive matrix 3
chr4_+_32238713 0.993 ENSMUST00000108180.2
Bach2
BTB and CNC homology 2
chr10_-_89257790 0.958 ENSMUST00000045601.7
Ano4
anoctamin 4
chr6_+_30723541 0.911 ENSMUST00000115127.1
Mest
mesoderm specific transcript
chr12_-_108893197 0.906 ENSMUST00000161154.1
ENSMUST00000161410.1
Wars

tryptophanyl-tRNA synthetase

chr7_-_17056669 0.898 ENSMUST00000037762.4
Hif3a
hypoxia inducible factor 3, alpha subunit
chr10_+_21993890 0.861 ENSMUST00000092673.4
Sgk1
serum/glucocorticoid regulated kinase 1
chr14_+_20674311 0.835 ENSMUST00000048657.8
Sec24c
Sec24 related gene family, member C (S. cerevisiae)
chrX_-_59567348 0.832 ENSMUST00000124402.1
Fgf13
fibroblast growth factor 13
chr14_+_58070547 0.815 ENSMUST00000165526.1
Fgf9
fibroblast growth factor 9
chr14_-_74947865 0.793 ENSMUST00000088970.5
Lrch1
leucine-rich repeats and calponin homology (CH) domain containing 1
chr8_-_94876269 0.764 ENSMUST00000046461.7
Dok4
docking protein 4
chr10_+_4611971 0.745 ENSMUST00000105590.1
ENSMUST00000067086.7
Esr1

estrogen receptor 1 (alpha)

chr11_+_94629741 0.689 ENSMUST00000021239.6
Lrrc59
leucine rich repeat containing 59
chr2_-_34754364 0.632 ENSMUST00000142436.1
ENSMUST00000113099.3
ENSMUST00000028224.8
Gapvd1


GTPase activating protein and VPS9 domains 1


chr7_-_141429351 0.562 ENSMUST00000164387.1
ENSMUST00000137488.1
ENSMUST00000084436.3
Cend1


cell cycle exit and neuronal differentiation 1


chr2_+_26319741 0.537 ENSMUST00000066889.6
Gpsm1
G-protein signalling modulator 1 (AGS3-like, C. elegans)
chr7_-_141429433 0.506 ENSMUST00000124444.1
Cend1
cell cycle exit and neuronal differentiation 1
chr8_+_106150359 0.498 ENSMUST00000034377.6
Pla2g15
phospholipase A2, group XV
chr4_-_128609981 0.450 ENSMUST00000141040.1
ENSMUST00000147876.1
ENSMUST00000097877.2
Zscan20


zinc finger and SCAN domains 20


chrX_+_74254782 0.423 ENSMUST00000119197.1
ENSMUST00000088313.4
Emd

emerin

chr6_+_115601907 0.361 ENSMUST00000000449.7
Mkrn2
makorin, ring finger protein, 2
chr11_+_4986824 0.360 ENSMUST00000009234.9
ENSMUST00000109897.1
Ap1b1

adaptor protein complex AP-1, beta 1 subunit

chr9_-_43105718 0.338 ENSMUST00000165665.1
Arhgef12
Rho guanine nucleotide exchange factor (GEF) 12
chr6_+_18848571 0.323 ENSMUST00000056398.8
Naa38
N(alpha)-acetyltransferase 38, NatC auxiliary subunit
chr8_+_69659263 0.317 ENSMUST00000169125.1
Zfp964
zinc finger protein 964
chr2_+_120977017 0.306 ENSMUST00000067582.7
Tmem62
transmembrane protein 62
chr4_+_41348996 0.273 ENSMUST00000072866.5
ENSMUST00000108060.3
Ubap1

ubiquitin-associated protein 1

chr17_-_32388885 0.269 ENSMUST00000087703.5
ENSMUST00000170603.1
Wiz

widely-interspaced zinc finger motifs

chr10_+_79910856 0.261 ENSMUST00000181321.1
Gm26602
predicted gene, 26602
chrX_+_74254736 0.247 ENSMUST00000096424.4
Emd
emerin
chr3_+_152210458 0.240 ENSMUST00000166984.1
ENSMUST00000106121.1
Fubp1

far upstream element (FUSE) binding protein 1

chr2_+_5845243 0.204 ENSMUST00000127116.1
Nudt5
nudix (nucleoside diphosphate linked moiety X)-type motif 5
chr7_+_120635176 0.166 ENSMUST00000033176.5
Uqcrc2
ubiquinol cytochrome c reductase core protein 2
chr3_+_79884576 0.147 ENSMUST00000145992.1
Fam198b
family with sequence similarity 198, member B
chr8_-_119778380 0.143 ENSMUST00000049156.5
Tldc1
TBC/LysM associated domain containing 1
chr7_+_45873127 0.139 ENSMUST00000107718.1
Kdelr1
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
chr7_+_45872772 0.125 ENSMUST00000002855.5
ENSMUST00000107719.1
Kdelr1

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1

chr13_+_49421229 0.106 ENSMUST00000021817.8
Ippk
inositol 1,3,4,5,6-pentakisphosphate 2-kinase
chr11_-_5915124 0.100 ENSMUST00000109823.2
ENSMUST00000109822.1
Gck

glucokinase

chr5_+_53590215 0.096 ENSMUST00000037618.6
Rbpj
recombination signal binding protein for immunoglobulin kappa J region
chr9_+_54586450 0.085 ENSMUST00000167866.1
Idh3a
isocitrate dehydrogenase 3 (NAD+) alpha
chr3_+_79884496 0.071 ENSMUST00000118853.1
Fam198b
family with sequence similarity 198, member B
chr9_-_109074049 0.066 ENSMUST00000161521.1
ENSMUST00000045011.2
Atrip

ATR interacting protein

chr11_-_97700327 0.059 ENSMUST00000018681.7
Pcgf2
polycomb group ring finger 2
chr14_+_76488436 0.053 ENSMUST00000101618.2
Tsc22d1
TSC22 domain family, member 1
chrX_+_106187100 0.044 ENSMUST00000081593.6
Pgk1
phosphoglycerate kinase 1
chr2_-_5845164 0.037 ENSMUST00000043864.3
Cdc123
cell division cycle 123
chr5_-_105239533 0.034 ENSMUST00000065588.6
Gbp10
guanylate-binding protein 10
chr2_-_5012716 0.030 ENSMUST00000027980.7
Mcm10
minichromosome maintenance deficient 10 (S. cerevisiae)
chr2_+_181365384 0.027 ENSMUST00000108807.2
Zgpat
zinc finger, CCCH-type with G patch domain
chrX_-_75874536 0.019 ENSMUST00000033547.7
Pls3
plastin 3 (T-isoform)
chr5_+_53267103 0.018 ENSMUST00000121042.1
Smim20
small integral membrane protein 20
chr4_-_152318458 0.010 ENSMUST00000170820.1
ENSMUST00000076183.5
Rnf207

ring finger protein 207


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.8 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.5 1.5 GO:0018298 protein-chromophore linkage(GO:0018298)
0.5 1.4 GO:0042536 negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.4 1.1 GO:0021933 radial glia guided migration of cerebellar granule cell(GO:0021933)
0.3 1.0 GO:0061588 calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylserine scrambling(GO:0061589) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591)
0.3 4.4 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.3 0.9 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.2 0.7 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.2 3.5 GO:0033623 regulation of integrin activation(GO:0033623)
0.2 1.1 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.1 0.8 GO:0098909 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200) regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909)
0.1 0.5 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.1 0.9 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.1 0.8 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.1 0.8 GO:0060484 male sex determination(GO:0030238) lung-associated mesenchyme development(GO:0060484)
0.1 0.2 GO:0019323 D-ribose metabolic process(GO:0006014) pentose catabolic process(GO:0019323)
0.0 0.1 GO:0060853 arterial endothelial cell fate commitment(GO:0060844) blood vessel endothelial cell fate commitment(GO:0060846) endothelial cell fate specification(GO:0060847) Notch signaling pathway involved in arterial endothelial cell fate commitment(GO:0060853) blood vessel endothelial cell fate specification(GO:0097101)
0.0 1.3 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.3 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.0 1.5 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.0 0.3 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 0.7 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.0 0.1 GO:0034287 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) negative regulation of epinephrine secretion(GO:0032811) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0 0.9 GO:0010883 regulation of lipid storage(GO:0010883)
0.0 1.2 GO:0014003 oligodendrocyte development(GO:0014003)
0.0 0.2 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 0.3 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 0.1 GO:1903204 negative regulation of oxidative stress-induced neuron death(GO:1903204)
0.0 0.4 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.1 GO:0006102 isocitrate metabolic process(GO:0006102)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.1 0.3 GO:0031417 NatC complex(GO:0031417)
0.1 0.7 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.1 0.7 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 0.8 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 2.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.3 GO:0000813 ESCRT I complex(GO:0000813)
0.0 1.5 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 3.5 GO:0001650 fibrillar center(GO:0001650)
0.0 0.1 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.2 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.0 0.7 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 1.2 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.8 GO:0016328 lateral plasma membrane(GO:0016328)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0009881 photoreceptor activity(GO:0009881)
0.3 3.8 GO:0035014 phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.3 0.9 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.2 3.5 GO:0031005 filamin binding(GO:0031005)
0.2 0.7 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.2 2.1 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.2 1.3 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.1 0.9 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.1 1.0 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.1 1.7 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.1 1.4 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 0.2 GO:0044715 8-oxo-dGDP phosphatase activity(GO:0044715)
0.1 1.1 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.1 0.3 GO:0046923 ER retention sequence binding(GO:0046923)
0.1 1.2 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.5 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.0 0.8 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 1.5 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 0.1 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.0 0.6 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.5 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.8 GO:0005158 insulin receptor binding(GO:0005158)
0.0 0.1 GO:0004340 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396)
0.0 3.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.0 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.0 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.9 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 2.0 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 0.8 PID_FGF_PATHWAY FGF signaling pathway
0.0 0.9 PID_FOXO_PATHWAY FoxO family signaling
0.0 0.8 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.5 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 0.8 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.1 1.3 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 3.6 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.8 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.9 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.9 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.4 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 1.3 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 1.5 REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)