Motif ID: Clock

Z-value: 0.417


Transcription factors associated with Clock:

Gene SymbolEntrez IDGene Name
Clock ENSMUSG00000029238.8 Clock

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Clockmm10_v2_chr5_-_76304474_76304548-0.163.2e-01Click!


Activity profile for motif Clock.

activity profile for motif Clock


Sorted Z-values histogram for motif Clock

Sorted Z-values for motif Clock



Network of associatons between targets according to the STRING database.



First level regulatory network of Clock

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_139543889 1.655 ENSMUST00000174792.1
ENSMUST00000031523.8
Uncx

UNC homeobox

chr7_-_144939823 1.556 ENSMUST00000093962.4
Ccnd1
cyclin D1
chr5_-_22344690 1.301 ENSMUST00000062372.7
ENSMUST00000161356.1
Reln

reelin

chr6_-_49214954 1.237 ENSMUST00000031838.7
Igf2bp3
insulin-like growth factor 2 mRNA binding protein 3
chr2_+_164769892 1.049 ENSMUST00000088248.6
ENSMUST00000001439.6
Ube2c

ubiquitin-conjugating enzyme E2C

chr1_-_75219245 0.977 ENSMUST00000079464.6
Tuba4a
tubulin, alpha 4A
chr14_-_20181773 0.941 ENSMUST00000024011.8
Kcnk5
potassium channel, subfamily K, member 5
chr5_+_93093428 0.854 ENSMUST00000074733.7
Sept11
septin 11
chr15_+_39076885 0.829 ENSMUST00000067072.3
Cthrc1
collagen triple helix repeat containing 1
chr11_+_101316200 0.825 ENSMUST00000142640.1
ENSMUST00000019470.7
Psme3

proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki)

chr11_+_101316917 0.824 ENSMUST00000151385.1
Psme3
proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki)
chr1_-_12991109 0.803 ENSMUST00000115403.2
ENSMUST00000115402.1
Slco5a1

solute carrier organic anion transporter family, member 5A1

chr4_-_97778042 0.780 ENSMUST00000146447.1
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr16_+_32608973 0.701 ENSMUST00000120680.1
Tfrc
transferrin receptor
chr4_-_133756769 0.689 ENSMUST00000008024.6
Arid1a
AT rich interactive domain 1A (SWI-like)
chr8_+_58912257 0.665 ENSMUST00000160055.1
BC030500
cDNA sequence BC030500
chr6_-_47813512 0.651 ENSMUST00000077290.7
Pdia4
protein disulfide isomerase associated 4
chr11_+_94629741 0.632 ENSMUST00000021239.6
Lrrc59
leucine rich repeat containing 59
chr4_-_57143437 0.623 ENSMUST00000095076.3
ENSMUST00000030142.3
Epb4.1l4b

erythrocyte protein band 4.1-like 4b

chr4_-_97584605 0.623 ENSMUST00000107067.1
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr5_+_146231211 0.622 ENSMUST00000161181.1
ENSMUST00000161652.1
ENSMUST00000031640.8
ENSMUST00000159467.1
Cdk8



cyclin-dependent kinase 8



chr5_-_76951560 0.608 ENSMUST00000140076.1
Ppat
phosphoribosyl pyrophosphate amidotransferase
chr1_-_82291370 0.607 ENSMUST00000069799.2
Irs1
insulin receptor substrate 1
chr12_+_59131473 0.607 ENSMUST00000177162.1
Ctage5
CTAGE family, member 5
chr9_-_106891401 0.602 ENSMUST00000069036.7
Manf
mesencephalic astrocyte-derived neurotrophic factor
chr4_-_97584612 0.585 ENSMUST00000107068.2
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr15_+_72913357 0.583 ENSMUST00000166418.2
Gm3150
predicted gene 3150
chr9_-_110654161 0.548 ENSMUST00000133191.1
ENSMUST00000167320.1
Nbeal2

neurobeachin-like 2

chr12_+_59131286 0.539 ENSMUST00000176464.1
ENSMUST00000170992.2
ENSMUST00000176322.1
Ctage5


CTAGE family, member 5


chr15_-_43170809 0.530 ENSMUST00000063492.6
Rspo2
R-spondin 2 homolog (Xenopus laevis)
chr11_-_100759942 0.528 ENSMUST00000107363.2
Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr2_-_130906338 0.527 ENSMUST00000146975.1
4930402H24Rik
RIKEN cDNA 4930402H24 gene
chr10_+_22158566 0.500 ENSMUST00000181645.1
ENSMUST00000105522.2
Raet1e
H60b
retinoic acid early transcript 1E
histocompatibility 60b
chr11_-_17211504 0.474 ENSMUST00000020317.7
Pno1
partner of NOB1 homolog (S. cerevisiae)
chr10_+_36974558 0.458 ENSMUST00000105510.1
Hdac2
histone deacetylase 2
chr2_+_160645881 0.448 ENSMUST00000109468.2
Top1
topoisomerase (DNA) I
chrX_-_48208566 0.442 ENSMUST00000037960.4
Zdhhc9
zinc finger, DHHC domain containing 9
chr9_-_114781986 0.436 ENSMUST00000035009.8
ENSMUST00000084867.7
Cmtm7

CKLF-like MARVEL transmembrane domain containing 7

chr11_-_100759740 0.430 ENSMUST00000107361.2
Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr16_-_45158453 0.420 ENSMUST00000181750.1
Slc35a5
solute carrier family 35, member A5
chr11_-_76217490 0.420 ENSMUST00000102500.4
Gemin4
gem (nuclear organelle) associated protein 4
chr9_-_48480540 0.420 ENSMUST00000034524.3
Rexo2
REX2, RNA exonuclease 2 homolog (S. cerevisiae)
chr17_-_35000848 0.393 ENSMUST00000166828.3
D17H6S56E-5
DNA segment, Chr 17, human D6S56E 5
chr2_+_18055203 0.377 ENSMUST00000028076.8
Mllt10
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
chr1_-_52499980 0.376 ENSMUST00000164747.1
Nab1
Ngfi-A binding protein 1
chr17_-_35000746 0.369 ENSMUST00000163360.1
D17H6S56E-5
DNA segment, Chr 17, human D6S56E 5
chr4_+_132274385 0.360 ENSMUST00000105963.1
Taf12
TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr2_+_115581667 0.351 ENSMUST00000166472.1
ENSMUST00000110918.2
BC052040

cDNA sequence BC052040

chr14_-_118706180 0.346 ENSMUST00000036554.6
ENSMUST00000166646.1
Abcc4

ATP-binding cassette, sub-family C (CFTR/MRP), member 4

chr4_-_132075250 0.335 ENSMUST00000105970.1
ENSMUST00000105975.1
Epb4.1

erythrocyte protein band 4.1

chr12_+_69372112 0.321 ENSMUST00000050063.7
Arf6
ADP-ribosylation factor 6
chr12_+_71136848 0.320 ENSMUST00000149564.1
ENSMUST00000045907.8
2700049A03Rik

RIKEN cDNA 2700049A03 gene

chr17_-_47611449 0.310 ENSMUST00000024783.8
Bysl
bystin-like
chr11_-_47379405 0.306 ENSMUST00000077221.5
Sgcd
sarcoglycan, delta (dystrophin-associated glycoprotein)
chr7_-_68749170 0.305 ENSMUST00000118110.1
ENSMUST00000048068.7
Arrdc4

arrestin domain containing 4

chr11_+_74830920 0.303 ENSMUST00000000291.2
Mnt
max binding protein
chr7_-_29505447 0.302 ENSMUST00000183096.1
ENSMUST00000085809.4
Sipa1l3

signal-induced proliferation-associated 1 like 3

chr9_+_58134017 0.300 ENSMUST00000134955.1
ENSMUST00000147134.1
ENSMUST00000170397.1
Stra6


stimulated by retinoic acid gene 6


chrX_-_95444789 0.296 ENSMUST00000084535.5
Amer1
APC membrane recruitment 1
chr9_+_44326804 0.296 ENSMUST00000054708.3
Dpagt1
dolichyl-phosphate (UDP-N-acetylglucosamine) acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
chr9_+_40801235 0.295 ENSMUST00000117870.1
ENSMUST00000117557.1
Hspa8

heat shock protein 8

chr17_-_45573253 0.292 ENSMUST00000165127.1
ENSMUST00000166469.1
ENSMUST00000024739.7
Hsp90ab1


heat shock protein 90 alpha (cytosolic), class B member 1


chr10_+_36974536 0.290 ENSMUST00000019911.7
Hdac2
histone deacetylase 2
chr5_+_76951307 0.289 ENSMUST00000031160.9
ENSMUST00000120912.1
ENSMUST00000117536.1
Paics


phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase


chr1_+_59684949 0.280 ENSMUST00000027174.3
Nop58
NOP58 ribonucleoprotein
chr10_-_127522428 0.278 ENSMUST00000026470.4
Shmt2
serine hydroxymethyltransferase 2 (mitochondrial)
chr4_+_132274369 0.270 ENSMUST00000030731.4
Taf12
TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr11_-_51756378 0.269 ENSMUST00000109092.1
ENSMUST00000064297.4
ENSMUST00000109097.2
Sec24a


Sec24 related gene family, member A (S. cerevisiae)


chr16_-_45158566 0.265 ENSMUST00000181177.1
Slc35a5
solute carrier family 35, member A5
chr6_+_125096145 0.258 ENSMUST00000112390.1
Chd4
chromodomain helicase DNA binding protein 4
chr3_+_41564880 0.253 ENSMUST00000168086.1
Phf17
PHD finger protein 17
chr18_+_35553401 0.253 ENSMUST00000181664.1
Snhg4
small nucleolar RNA host gene 4 (non-protein coding)
chrX_+_56786527 0.251 ENSMUST00000144600.1
Fhl1
four and a half LIM domains 1
chr16_-_45158183 0.250 ENSMUST00000114600.1
Slc35a5
solute carrier family 35, member A5
chr19_+_41981709 0.248 ENSMUST00000026170.1
Ubtd1
ubiquitin domain containing 1
chr2_+_83644435 0.241 ENSMUST00000081591.6
Zc3h15
zinc finger CCCH-type containing 15
chr11_-_70982987 0.236 ENSMUST00000078528.6
C1qbp
complement component 1, q subcomponent binding protein
chr16_+_94085226 0.227 ENSMUST00000072182.7
Sim2
single-minded homolog 2 (Drosophila)
chr15_-_10714612 0.227 ENSMUST00000169385.1
Rai14
retinoic acid induced 14
chr4_+_123282778 0.216 ENSMUST00000106243.1
ENSMUST00000106241.1
ENSMUST00000080178.6
Pabpc4


poly(A) binding protein, cytoplasmic 4


chr3_+_88532314 0.212 ENSMUST00000172699.1
Mex3a
mex3 homolog A (C. elegans)
chr10_+_69534039 0.212 ENSMUST00000182557.1
Ank3
ankyrin 3, epithelial
chr19_+_45015168 0.212 ENSMUST00000039016.6
Lzts2
leucine zipper, putative tumor suppressor 2
chr4_+_32657107 0.205 ENSMUST00000071642.4
ENSMUST00000178134.1
Mdn1

midasin homolog (yeast)

chr19_+_46056539 0.205 ENSMUST00000111899.1
ENSMUST00000099392.3
ENSMUST00000062322.4
Pprc1


peroxisome proliferative activated receptor, gamma, coactivator-related 1


chr8_+_90828820 0.204 ENSMUST00000109614.2
ENSMUST00000048665.6
Chd9

chromodomain helicase DNA binding protein 9

chr16_-_45158624 0.197 ENSMUST00000180636.1
Slc35a5
solute carrier family 35, member A5
chr5_+_76951382 0.195 ENSMUST00000141687.1
Paics
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase
chr5_-_137786651 0.194 ENSMUST00000031740.9
Mepce
methylphosphate capping enzyme
chr16_-_45158650 0.190 ENSMUST00000023344.3
Slc35a5
solute carrier family 35, member A5
chr4_-_129742275 0.190 ENSMUST00000066257.5
Khdrbs1
KH domain containing, RNA binding, signal transduction associated 1
chr7_-_98361275 0.186 ENSMUST00000094161.4
ENSMUST00000164726.1
ENSMUST00000167405.1
Tsku


tsukushi


chr17_-_87265866 0.186 ENSMUST00000145895.1
ENSMUST00000129616.1
ENSMUST00000155904.1
ENSMUST00000151155.1
ENSMUST00000144236.1
ENSMUST00000024963.3
Mcfd2





multiple coagulation factor deficiency 2





chrX_+_6047453 0.186 ENSMUST00000103007.3
Nudt11
nudix (nucleoside diphosphate linked moiety X)-type motif 11
chr11_-_70410010 0.184 ENSMUST00000019065.3
ENSMUST00000135148.1
Pelp1

proline, glutamic acid and leucine rich protein 1

chr1_-_166409773 0.182 ENSMUST00000135673.1
ENSMUST00000079972.6
ENSMUST00000169324.1
ENSMUST00000111411.2
ENSMUST00000128861.1
Pogk




pogo transposable element with KRAB domain




chr16_+_43889936 0.181 ENSMUST00000151183.1
2610015P09Rik
RIKEN cDNA 2610015P09 gene
chr4_-_124693568 0.175 ENSMUST00000030738.7
Utp11l
UTP11-like, U3 small nucleolar ribonucleoprotein, (yeast)
chr17_+_71204647 0.174 ENSMUST00000126681.1
Lpin2
lipin 2
chr10_+_44268328 0.172 ENSMUST00000039286.4
Atg5
autophagy related 5
chr18_+_32837225 0.170 ENSMUST00000166214.1
ENSMUST00000053663.9
Wdr36

WD repeat domain 36

chr18_+_76241580 0.167 ENSMUST00000168423.1
ENSMUST00000091831.6
Smad2

SMAD family member 2

chr6_-_23839137 0.165 ENSMUST00000166458.2
ENSMUST00000142913.2
ENSMUST00000115357.1
ENSMUST00000069074.7
ENSMUST00000115361.2
ENSMUST00000018122.7
ENSMUST00000115355.1
ENSMUST00000115356.2
Cadps2







Ca2+-dependent activator protein for secretion 2







chr1_-_55088156 0.163 ENSMUST00000127861.1
ENSMUST00000144077.1
Hspd1

heat shock protein 1 (chaperonin)

chr16_-_35490873 0.161 ENSMUST00000023550.7
Pdia5
protein disulfide isomerase associated 5
chr7_-_98361310 0.159 ENSMUST00000165257.1
Tsku
tsukushi
chr4_+_107968332 0.158 ENSMUST00000106713.3
Slc1a7
solute carrier family 1 (glutamate transporter), member 7
chr9_-_106891870 0.155 ENSMUST00000160503.1
ENSMUST00000159620.2
ENSMUST00000160978.1
Manf


mesencephalic astrocyte-derived neurotrophic factor


chr11_+_17211912 0.154 ENSMUST00000046955.6
Wdr92
WD repeat domain 92
chr9_+_58134535 0.154 ENSMUST00000128378.1
ENSMUST00000150820.1
ENSMUST00000167479.1
ENSMUST00000134450.1
Stra6



stimulated by retinoic acid gene 6



chr1_-_55088024 0.151 ENSMUST00000027123.8
Hspd1
heat shock protein 1 (chaperonin)
chr11_-_106789157 0.148 ENSMUST00000129585.1
Ddx5
DEAD (Asp-Glu-Ala-Asp) box polypeptide 5
chr4_+_44756609 0.140 ENSMUST00000143385.1
Zcchc7
zinc finger, CCHC domain containing 7
chr17_-_28486082 0.139 ENSMUST00000079413.3
Fkbp5
FK506 binding protein 5
chr16_+_43889896 0.127 ENSMUST00000122014.1
ENSMUST00000178400.1
2610015P09Rik

RIKEN cDNA 2610015P09 gene

chr19_-_29812952 0.127 ENSMUST00000099525.3
Ranbp6
RAN binding protein 6
chr14_-_89898466 0.125 ENSMUST00000081204.4
Gm10110
predicted gene 10110
chr13_-_75943812 0.121 ENSMUST00000022078.5
ENSMUST00000109606.1
Rhobtb3

Rho-related BTB domain containing 3

chr16_+_45158725 0.116 ENSMUST00000023343.3
Atg3
autophagy related 3
chr9_-_57606234 0.110 ENSMUST00000045068.8
Cplx3
complexin 3
chr8_+_123186235 0.107 ENSMUST00000019422.4
Dpep1
dipeptidase 1 (renal)
chr19_+_6975048 0.106 ENSMUST00000070850.6
Ppp1r14b
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr3_+_145576196 0.102 ENSMUST00000098534.4
Znhit6
zinc finger, HIT type 6
chr5_+_76974683 0.101 ENSMUST00000101087.3
ENSMUST00000120550.1
Srp72

signal recognition particle 72

chr17_+_43016536 0.100 ENSMUST00000024708.4
Tnfrsf21
tumor necrosis factor receptor superfamily, member 21
chr17_+_35001282 0.100 ENSMUST00000174260.1
Vars
valyl-tRNA synthetase
chr16_+_43889800 0.099 ENSMUST00000132859.1
2610015P09Rik
RIKEN cDNA 2610015P09 gene
chr16_-_43889669 0.098 ENSMUST00000023387.7
Qtrtd1
queuine tRNA-ribosyltransferase domain containing 1
chr4_+_57568144 0.098 ENSMUST00000102904.3
Palm2
paralemmin 2
chr11_-_120348513 0.092 ENSMUST00000071555.6
Actg1
actin, gamma, cytoplasmic 1
chr11_-_106788845 0.091 ENSMUST00000123339.1
Ddx5
DEAD (Asp-Glu-Ala-Asp) box polypeptide 5
chr2_-_38926217 0.088 ENSMUST00000076275.4
ENSMUST00000142130.1
Nr6a1

nuclear receptor subfamily 6, group A, member 1

chr11_-_72215592 0.086 ENSMUST00000021157.8
Med31
mediator of RNA polymerase II transcription, subunit 31 homolog (yeast)
chrX_+_36328353 0.081 ENSMUST00000016383.3
Lonrf3
LON peptidase N-terminal domain and ring finger 3
chr5_+_120116480 0.073 ENSMUST00000031590.8
Rbm19
RNA binding motif protein 19
chr4_-_11386757 0.069 ENSMUST00000108313.1
ENSMUST00000108311.2
Esrp1

epithelial splicing regulatory protein 1

chr11_+_106216926 0.063 ENSMUST00000021046.5
Ddx42
DEAD (Asp-Glu-Ala-Asp) box polypeptide 42
chr11_+_72441341 0.057 ENSMUST00000045633.5
Mybbp1a
MYB binding protein (P160) 1a
chr7_+_127746775 0.052 ENSMUST00000033081.7
Fbxl19
F-box and leucine-rich repeat protein 19
chr12_-_31950170 0.051 ENSMUST00000176520.1
Hbp1
high mobility group box transcription factor 1
chr11_-_52000432 0.048 ENSMUST00000020657.6
Ube2b
ubiquitin-conjugating enzyme E2B
chr8_+_125734203 0.047 ENSMUST00000034313.6
ENSMUST00000065135.5
Ntpcr

nucleoside-triphosphatase, cancer-related

chrX_-_7572843 0.045 ENSMUST00000132788.1
Ppp1r3f
protein phosphatase 1, regulatory (inhibitor) subunit 3F
chr5_+_66676098 0.044 ENSMUST00000031131.9
Uchl1
ubiquitin carboxy-terminal hydrolase L1
chr3_-_95882193 0.040 ENSMUST00000159863.1
ENSMUST00000159739.1
ENSMUST00000036418.3
Gm129


predicted gene 129


chr7_-_46795661 0.038 ENSMUST00000123725.1
Hps5
Hermansky-Pudlak syndrome 5 homolog (human)
chr9_+_95637601 0.036 ENSMUST00000015498.8
Pcolce2
procollagen C-endopeptidase enhancer 2
chr5_+_129941949 0.032 ENSMUST00000051758.7
ENSMUST00000073945.4
Vkorc1l1

vitamin K epoxide reductase complex, subunit 1-like 1

chr4_-_148444744 0.022 ENSMUST00000051633.2
Ubiad1
UbiA prenyltransferase domain containing 1
chr10_+_17723220 0.017 ENSMUST00000038107.7
Cited2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
chr2_+_130906461 0.015 ENSMUST00000028781.8
Atrn
attractin
chr7_-_46795881 0.015 ENSMUST00000107653.1
ENSMUST00000107654.1
ENSMUST00000014562.7
ENSMUST00000152759.1
Hps5



Hermansky-Pudlak syndrome 5 homolog (human)



chr2_-_163419508 0.015 ENSMUST00000046908.3
Oser1
oxidative stress responsive serine rich 1
chr12_+_8674681 0.014 ENSMUST00000168361.1
ENSMUST00000169750.1
ENSMUST00000163730.1
Pum2


pumilio 2 (Drosophila)


chr11_+_78178651 0.013 ENSMUST00000092880.7
ENSMUST00000127587.1
ENSMUST00000108338.1
Tlcd1


TLC domain containing 1


chr11_-_52000748 0.010 ENSMUST00000109086.1
Ube2b
ubiquitin-conjugating enzyme E2B
chr9_+_44067072 0.006 ENSMUST00000177054.1
Usp2
ubiquitin specific peptidase 2
chr13_-_100015562 0.005 ENSMUST00000022148.6
Mccc2
methylcrotonoyl-Coenzyme A carboxylase 2 (beta)
chr11_-_106216318 0.003 ENSMUST00000002043.3
Ccdc47
coiled-coil domain containing 47
chr10_-_14544972 0.002 ENSMUST00000041168.4
Gpr126
G protein-coupled receptor 126
chr5_-_74702891 0.002 ENSMUST00000117388.1
Lnx1
ligand of numb-protein X 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0097477 lateral motor column neuron migration(GO:0097477)
0.3 0.9 GO:1903334 positive regulation of protein folding(GO:1903334)
0.3 0.8 GO:0002014 vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure(GO:0002014)
0.2 1.6 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.2 1.5 GO:0006344 maintenance of chromatin silencing(GO:0006344)
0.2 1.0 GO:0010993 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.2 1.7 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.2 0.5 GO:0070889 platelet alpha granule organization(GO:0070889)
0.1 0.5 GO:0060535 trachea cartilage morphogenesis(GO:0060535)
0.1 0.6 GO:0006543 glutamine catabolic process(GO:0006543)
0.1 0.6 GO:0090273 regulation of somatostatin secretion(GO:0090273)
0.1 0.4 GO:0002337 B-1a B cell differentiation(GO:0002337)
0.1 0.3 GO:0002842 positive regulation of T cell mediated immune response to tumor cell(GO:0002842) protein import into mitochondrial intermembrane space(GO:0045041)
0.1 0.3 GO:0097278 transforming growth factor beta activation(GO:0036363) complement-dependent cytotoxicity(GO:0097278)
0.1 0.5 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.1 0.9 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 0.5 GO:0046864 retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865) alveolar primary septum development(GO:0061143)
0.1 0.2 GO:2000510 regulation of MDA-5 signaling pathway(GO:0039533) positive regulation of dendritic cell chemotaxis(GO:2000510)
0.1 0.3 GO:0006545 glycine biosynthetic process(GO:0006545)
0.1 0.3 GO:0061073 ciliary body morphogenesis(GO:0061073)
0.1 0.8 GO:0033690 positive regulation of osteoblast proliferation(GO:0033690)
0.1 0.4 GO:0048254 snoRNA localization(GO:0048254)
0.1 0.2 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241)
0.1 0.8 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.1 0.2 GO:0035973 aggrephagy(GO:0035973)
0.1 0.4 GO:0006265 DNA topological change(GO:0006265)
0.1 0.3 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.1 0.6 GO:0090209 negative regulation of triglyceride metabolic process(GO:0090209)
0.1 0.7 GO:0033572 transferrin transport(GO:0033572)
0.0 0.3 GO:2001012 mesenchymal cell differentiation involved in kidney development(GO:0072161) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.0 0.3 GO:0019348 dolichol metabolic process(GO:0019348)
0.0 0.2 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352) positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224)
0.0 0.4 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.3 GO:0072553 terminal button organization(GO:0072553)
0.0 0.3 GO:0006855 drug transmembrane transport(GO:0006855)
0.0 0.1 GO:0032696 negative regulation of interleukin-13 production(GO:0032696) negative regulation of interleukin-10 secretion(GO:2001180)
0.0 0.2 GO:1901911 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.0 0.6 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 0.2 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.0 0.2 GO:1990504 dense core granule exocytosis(GO:1990504)
0.0 0.2 GO:0040031 snRNA modification(GO:0040031)
0.0 0.3 GO:0034143 regulation of toll-like receptor 4 signaling pathway(GO:0034143)
0.0 0.0 GO:0007412 axon target recognition(GO:0007412)
0.0 0.2 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.5 GO:0001913 T cell mediated cytotoxicity(GO:0001913)
0.0 0.1 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.0 1.9 GO:2000045 regulation of G1/S transition of mitotic cell cycle(GO:2000045)
0.0 0.2 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 0.1 GO:0042373 vitamin K metabolic process(GO:0042373)
0.0 0.1 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.4 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.0 0.3 GO:0051443 positive regulation of ubiquitin-protein transferase activity(GO:0051443)
0.0 0.3 GO:0001829 trophectodermal cell differentiation(GO:0001829)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.6 GO:0008537 proteasome activator complex(GO:0008537)
0.2 0.6 GO:0005899 insulin receptor complex(GO:0005899)
0.1 0.5 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.1 0.3 GO:0031088 platelet dense granule membrane(GO:0031088)
0.1 0.4 GO:0001651 dense fibrillar component(GO:0001651)
0.1 0.6 GO:0000125 PCAF complex(GO:0000125)
0.1 0.3 GO:0043202 lysosomal lumen(GO:0043202)
0.1 0.7 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.1 0.3 GO:0016012 sarcoglycan complex(GO:0016012)
0.1 0.7 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.1 0.3 GO:0070552 BRISC complex(GO:0070552)
0.1 0.3 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.1 0.2 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
0.1 0.3 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 0.3 GO:0061689 tricellular tight junction(GO:0061689)
0.1 0.7 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.3 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 1.0 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.2 GO:0032444 activin responsive factor complex(GO:0032444)
0.0 0.2 GO:0071141 SMAD protein complex(GO:0071141)
0.0 0.4 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 0.4 GO:0032797 SMN complex(GO:0032797)
0.0 0.3 GO:0090543 Flemming body(GO:0090543)
0.0 0.2 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0 1.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.1 GO:0070761 pre-snoRNP complex(GO:0070761)
0.0 0.1 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.0 0.3 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.3 GO:0071564 npBAF complex(GO:0071564)
0.0 0.6 GO:0016592 mediator complex(GO:0016592)
0.0 0.6 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.1 GO:0031084 BLOC-2 complex(GO:0031084)
0.0 0.1 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.0 0.3 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545) nuclear transcriptional repressor complex(GO:0090568)
0.0 0.8 GO:0005581 collagen trimer(GO:0005581)
0.0 0.2 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0004998 transferrin receptor activity(GO:0004998)
0.2 1.3 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.2 0.7 GO:0035851 histone deacetylase activity (H4-K16 specific)(GO:0034739) Krueppel-associated box domain binding(GO:0035851)
0.2 1.6 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 0.4 GO:0097100 supercoiled DNA binding(GO:0097100)
0.1 0.3 GO:0031686 A1 adenosine receptor binding(GO:0031686)
0.1 0.3 GO:0019776 Atg8 ligase activity(GO:0019776)
0.1 0.3 GO:0008732 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.1 0.9 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 0.2 GO:0035500 MH2 domain binding(GO:0035500)
0.1 0.3 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.1 0.8 GO:0015037 peptide disulfide oxidoreductase activity(GO:0015037)
0.1 0.8 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.1 0.5 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.1 0.6 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.1 0.2 GO:0030984 kininogen binding(GO:0030984)
0.1 0.2 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 1.3 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.1 0.3 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.1 1.5 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.3 GO:0002135 CTP binding(GO:0002135)
0.0 0.4 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.0 1.2 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.3 GO:0015245 fatty acid transporter activity(GO:0015245)
0.0 0.2 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 0.2 GO:0000298 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.0 0.1 GO:0070573 metallodipeptidase activity(GO:0070573)
0.0 0.8 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.3 GO:0031996 thioesterase binding(GO:0031996)
0.0 0.1 GO:0030911 TPR domain binding(GO:0030911)
0.0 0.5 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 1.1 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.4 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.6 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 0.7 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.4 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 1.3 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.4 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.5 GO:0051183 vitamin transporter activity(GO:0051183)
0.0 1.0 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.0 0.6 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.0 0.0 GO:2001069 glycogen binding(GO:2001069)
0.0 0.0 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.8 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.0 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.6 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.0 0.6 PID_MYC_PATHWAY C-MYC pathway
0.0 0.7 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.3 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 1.2 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 0.3 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 1.0 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 1.0 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1 1.6 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.3 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.6 REACTOME_SOS_MEDIATED_SIGNALLING Genes involved in SOS-mediated signalling
0.0 0.7 REACTOME_TRANSFERRIN_ENDOCYTOSIS_AND_RECYCLING Genes involved in Transferrin endocytosis and recycling
0.0 0.2 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 1.0 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.5 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 1.4 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.2 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.0 0.2 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.3 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.3 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.6 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.3 REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein