Motif ID: Irf3

Z-value: 0.906


Transcription factors associated with Irf3:

Gene SymbolEntrez IDGene Name
Irf3 ENSMUSG00000003184.8 Irf3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irf3mm10_v2_chr7_+_44997648_449977000.342.9e-02Click!


Activity profile for motif Irf3.

activity profile for motif Irf3


Sorted Z-values histogram for motif Irf3

Sorted Z-values for motif Irf3



Network of associatons between targets according to the STRING database.



First level regulatory network of Irf3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_36409719 4.159 ENSMUST00000062389.5
Pcgf5
polycomb group ring finger 5
chr8_-_71537402 3.788 ENSMUST00000051672.7
Bst2
bone marrow stromal cell antigen 2
chr18_-_32559914 3.481 ENSMUST00000174000.1
ENSMUST00000174459.1
Gypc

glycophorin C

chr2_-_105399286 3.001 ENSMUST00000006128.6
Rcn1
reticulocalbin 1
chr15_+_32920723 2.657 ENSMUST00000022871.5
Sdc2
syndecan 2
chr17_+_75178797 2.420 ENSMUST00000112516.1
ENSMUST00000135447.1
Ltbp1

latent transforming growth factor beta binding protein 1

chr2_+_122147680 2.350 ENSMUST00000102476.4
B2m
beta-2 microglobulin
chr17_+_75178911 2.329 ENSMUST00000112514.1
Ltbp1
latent transforming growth factor beta binding protein 1
chr16_+_35938470 2.314 ENSMUST00000114878.1
Parp9
poly (ADP-ribose) polymerase family, member 9
chr6_-_39118211 2.203 ENSMUST00000038398.6
Parp12
poly (ADP-ribose) polymerase family, member 12
chr16_+_35938972 2.181 ENSMUST00000023622.6
ENSMUST00000114877.1
Parp9

poly (ADP-ribose) polymerase family, member 9

chr2_-_51934644 1.931 ENSMUST00000165313.1
Rbm43
RNA binding motif protein 43
chr5_+_114896936 1.923 ENSMUST00000031542.9
ENSMUST00000146072.1
ENSMUST00000150361.1
Oasl2


2'-5' oligoadenylate synthetase-like 2


chr16_-_10785525 1.674 ENSMUST00000038099.4
Socs1
suppressor of cytokine signaling 1
chr4_-_40239779 1.596 ENSMUST00000037907.6
Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr10_-_87493651 1.588 ENSMUST00000020243.7
Ascl1
achaete-scute complex homolog 1 (Drosophila)
chr13_+_74639866 1.530 ENSMUST00000169114.1
Erap1
endoplasmic reticulum aminopeptidase 1
chr6_-_34317442 1.521 ENSMUST00000154655.1
ENSMUST00000102980.4
Akr1b3

aldo-keto reductase family 1, member B3 (aldose reductase)

chr3_+_142560052 1.418 ENSMUST00000106222.2
Gbp3
guanylate binding protein 3
chr3_+_142560108 1.415 ENSMUST00000128609.1
ENSMUST00000029935.7
Gbp3

guanylate binding protein 3

chr3_+_81932601 1.413 ENSMUST00000029649.2
Ctso
cathepsin O
chr2_-_51934943 1.360 ENSMUST00000102767.1
ENSMUST00000102768.1
Rbm43

RNA binding motif protein 43

chr11_-_48871408 1.319 ENSMUST00000097271.2
Irgm1
immunity-related GTPase family M member 1
chr7_-_116198487 1.286 ENSMUST00000181981.1
Plekha7
pleckstrin homology domain containing, family A member 7
chr13_-_23710714 1.276 ENSMUST00000091707.6
ENSMUST00000006787.7
ENSMUST00000091706.6
Hfe


hemochromatosis


chr2_+_167062934 1.075 ENSMUST00000125674.1
1500012F01Rik
RIKEN cDNA 1500012F01 gene
chr3_+_142560351 1.053 ENSMUST00000106221.1
Gbp3
guanylate binding protein 3
chr4_-_40239700 1.053 ENSMUST00000142055.1
Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr19_+_43752996 1.052 ENSMUST00000026199.7
ENSMUST00000112047.3
ENSMUST00000153295.1
Cutc


cutC copper transporter homolog (E.coli)


chr7_-_104315455 1.048 ENSMUST00000106837.1
ENSMUST00000106839.2
ENSMUST00000070943.6
Trim12a


tripartite motif-containing 12A


chr7_-_45136231 1.026 ENSMUST00000124300.1
ENSMUST00000085377.5
Rpl13a
Flt3l
ribosomal protein L13A
FMS-like tyrosine kinase 3 ligand
chr14_-_65833963 1.018 ENSMUST00000022613.9
Esco2
establishment of cohesion 1 homolog 2 (S. cerevisiae)
chr7_-_102565425 0.992 ENSMUST00000106913.1
ENSMUST00000033264.4
Trim21

tripartite motif-containing 21

chr6_-_23839137 0.983 ENSMUST00000166458.2
ENSMUST00000142913.2
ENSMUST00000115357.1
ENSMUST00000069074.7
ENSMUST00000115361.2
ENSMUST00000018122.7
ENSMUST00000115355.1
ENSMUST00000115356.2
Cadps2







Ca2+-dependent activator protein for secretion 2







chr9_-_35176039 0.982 ENSMUST00000119847.1
ENSMUST00000034539.5
Dcps

decapping enzyme, scavenger

chr14_+_14012491 0.902 ENSMUST00000022257.2
Atxn7
ataxin 7
chr11_+_119393060 0.890 ENSMUST00000131035.2
ENSMUST00000093902.5
Rnf213

ring finger protein 213

chr7_-_100514800 0.821 ENSMUST00000054923.7
Dnajb13
DnaJ (Hsp40) related, subfamily B, member 13
chr5_-_137116177 0.796 ENSMUST00000054384.5
ENSMUST00000152207.1
Trim56

tripartite motif-containing 56

chr16_-_35939082 0.748 ENSMUST00000081933.7
ENSMUST00000114885.1
Dtx3l

deltex 3-like (Drosophila)

chr2_-_173276144 0.735 ENSMUST00000139306.1
Pmepa1
prostate transmembrane protein, androgen induced 1
chr6_-_54972603 0.671 ENSMUST00000060655.8
Nod1
nucleotide-binding oligomerization domain containing 1
chr3_-_50443603 0.649 ENSMUST00000029297.4
Slc7a11
solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
chr3_+_142530329 0.636 ENSMUST00000171263.1
ENSMUST00000045097.9
Gbp7

guanylate binding protein 7

chr13_+_40859768 0.602 ENSMUST00000110191.2
Gcnt2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr8_-_70766654 0.595 ENSMUST00000034299.5
Ifi30
interferon gamma inducible protein 30
chr11_+_58199556 0.575 ENSMUST00000058704.8
ENSMUST00000035266.4
ENSMUST00000094169.4
ENSMUST00000168280.1
Irgm2
Igtp


immunity-related GTPase family M member 2
interferon gamma induced GTPase


chr2_-_155826647 0.533 ENSMUST00000109638.1
ENSMUST00000134278.1
Eif6

eukaryotic translation initiation factor 6

chr11_-_48871344 0.527 ENSMUST00000049519.3
Irgm1
immunity-related GTPase family M member 1
chr1_+_37890477 0.493 ENSMUST00000027256.5
Mrpl30
mitochondrial ribosomal protein L30
chrX_+_101429555 0.485 ENSMUST00000033673.6
Nono
non-POU-domain-containing, octamer binding protein
chr2_+_180589245 0.483 ENSMUST00000029087.3
Ogfr
opioid growth factor receptor
chr14_+_55578123 0.453 ENSMUST00000174484.1
Psme1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr7_-_104353328 0.452 ENSMUST00000130139.1
ENSMUST00000059037.8
Trim12c

tripartite motif-containing 12C

chr15_+_79892397 0.449 ENSMUST00000175714.1
ENSMUST00000109620.3
ENSMUST00000165537.1
Apobec3


apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3


chr14_+_55578360 0.443 ENSMUST00000174259.1
ENSMUST00000174563.1
ENSMUST00000089619.6
ENSMUST00000172738.1
Psme1



proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)



chr14_-_55591077 0.404 ENSMUST00000161807.1
ENSMUST00000111378.3
ENSMUST00000159687.1
Psme2


proteasome (prosome, macropain) activator subunit 2 (PA28 beta)


chrX_+_68678712 0.398 ENSMUST00000114654.1
ENSMUST00000114655.1
ENSMUST00000114657.2
ENSMUST00000114653.1
Fmr1



fragile X mental retardation syndrome 1



chr11_+_72301613 0.343 ENSMUST00000151440.1
ENSMUST00000146233.1
ENSMUST00000140842.2
Xaf1


XIAP associated factor 1


chr15_+_79892436 0.334 ENSMUST00000175752.1
ENSMUST00000176325.1
Apobec3

apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3

chr10_-_81496313 0.312 ENSMUST00000118498.1
Ncln
nicalin homolog (zebrafish)
chr7_-_15922361 0.302 ENSMUST00000044355.7
Sepw1
selenoprotein W, muscle 1
chr10_-_81496329 0.291 ENSMUST00000020463.7
Ncln
nicalin homolog (zebrafish)
chrX_+_68678541 0.272 ENSMUST00000088546.5
Fmr1
fragile X mental retardation syndrome 1
chr16_-_19706365 0.225 ENSMUST00000081880.5
Lamp3
lysosomal-associated membrane protein 3
chr17_+_57358682 0.209 ENSMUST00000086763.5
ENSMUST00000004850.7
Emr1

EGF-like module containing, mucin-like, hormone receptor-like sequence 1

chr19_-_44146433 0.188 ENSMUST00000079033.4
Bloc1s2
biogenesis of lysosome-related organelles complex-1, subunit 2
chr2_+_152962485 0.182 ENSMUST00000099197.2
ENSMUST00000103155.3
Ttll9

tubulin tyrosine ligase-like family, member 9

chr11_-_49064202 0.174 ENSMUST00000046745.6
Tgtp2
T cell specific GTPase 2
chr1_+_61638819 0.166 ENSMUST00000138768.1
ENSMUST00000075374.3
Pard3b

par-3 partitioning defective 3 homolog B (C. elegans)

chr2_-_62646146 0.163 ENSMUST00000112459.3
ENSMUST00000028259.5
Ifih1

interferon induced with helicase C domain 1

chr17_+_34187789 0.157 ENSMUST00000041633.8
Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr12_+_70974621 0.139 ENSMUST00000160027.1
ENSMUST00000160864.1
Psma3

proteasome (prosome, macropain) subunit, alpha type 3

chr17_+_34187545 0.130 ENSMUST00000170086.1
Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr9_+_108508005 0.090 ENSMUST00000006838.8
ENSMUST00000134939.1
Qars

glutaminyl-tRNA synthetase

chrX_+_68678624 0.067 ENSMUST00000114656.1
Fmr1
fragile X mental retardation syndrome 1
chr2_-_145935014 0.046 ENSMUST00000001818.4
Crnkl1
Crn, crooked neck-like 1 (Drosophila)
chr16_-_35871544 0.023 ENSMUST00000042665.8
Parp14
poly (ADP-ribose) polymerase family, member 14
chr15_+_39112868 0.022 ENSMUST00000022909.8
Dcaf13
DDB1 and CUL4 associated factor 13
chr16_+_23609895 0.015 ENSMUST00000038423.5
Rtp4
receptor transporter protein 4
chr16_+_38346986 0.011 ENSMUST00000050273.8
ENSMUST00000120495.1
ENSMUST00000119704.1
Cox17

Gm21987
cytochrome c oxidase assembly protein 17

predicted gene 21987

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.5 GO:1901252 regulation of intracellular transport of viral material(GO:1901252)
0.9 3.6 GO:0034759 regulation of iron ion transport(GO:0034756) regulation of iron ion transmembrane transport(GO:0034759)
0.9 8.6 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
0.7 2.6 GO:0009597 detection of virus(GO:0009597)
0.5 1.6 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) musculoskeletal movement, spinal reflex action(GO:0050883) olfactory pit development(GO:0060166)
0.5 1.5 GO:0006059 hexitol metabolic process(GO:0006059) alditol biosynthetic process(GO:0019401)
0.3 1.0 GO:0090289 regulation of osteoclast proliferation(GO:0090289)
0.3 4.5 GO:0044406 adhesion of symbiont to host(GO:0044406)
0.2 1.3 GO:0045218 zonula adherens maintenance(GO:0045218)
0.2 1.0 GO:0034421 post-translational protein acetylation(GO:0034421)
0.2 1.8 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.2 4.7 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.2 1.0 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
0.1 0.6 GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
0.1 0.7 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.1 1.0 GO:1990504 dense core granule exocytosis(GO:1990504)
0.1 0.7 GO:0042228 interleukin-8 biosynthetic process(GO:0042228)
0.1 0.5 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.1 0.8 GO:0032196 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196)
0.1 0.9 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.1 0.6 GO:0036438 maintenance of lens transparency(GO:0036438)
0.1 1.0 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.1 1.3 GO:0019884 antigen processing and presentation of exogenous antigen(GO:0019884)
0.1 0.9 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.1 0.5 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.1 3.5 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.1 0.6 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.1 1.1 GO:0055070 copper ion homeostasis(GO:0055070)
0.1 0.2 GO:0035547 interferon-beta secretion(GO:0035546) regulation of interferon-beta secretion(GO:0035547) positive regulation of interferon-beta secretion(GO:0035549)
0.0 0.2 GO:0035455 response to interferon-alpha(GO:0035455)
0.0 2.7 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)
0.0 0.8 GO:0035082 axoneme assembly(GO:0035082)
0.0 0.6 GO:0031648 protein destabilization(GO:0031648)
0.0 0.0 GO:1904959 regulation of electron carrier activity(GO:1904732) regulation of cytochrome-c oxidase activity(GO:1904959)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.7 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.4 5.1 GO:0020003 symbiont-containing vacuole(GO:0020003)
0.4 1.5 GO:0097454 Schwann cell microvillus(GO:0097454)
0.4 3.6 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.2 0.9 GO:0008537 proteasome activator complex(GO:0008537)
0.2 0.7 GO:1902737 viral replication complex(GO:0019034) dendritic filopodium(GO:1902737)
0.1 1.0 GO:0097452 GAIT complex(GO:0097452)
0.1 1.8 GO:0044754 autolysosome(GO:0044754)
0.1 1.3 GO:0005915 zonula adherens(GO:0005915)
0.1 0.5 GO:1990462 omegasome(GO:1990462)
0.1 1.0 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.1 0.5 GO:0005638 lamin filament(GO:0005638)
0.1 0.2 GO:0097233 lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
0.1 0.5 GO:0042382 paraspeckles(GO:0042382)
0.1 4.2 GO:0031519 PcG protein complex(GO:0031519)
0.0 0.3 GO:0042825 TAP complex(GO:0042825)
0.0 0.1 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 3.5 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 1.5 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 3.8 GO:0031225 anchored component of membrane(GO:0031225)
0.0 2.6 GO:0032587 ruffle membrane(GO:0032587)
0.0 2.7 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 1.0 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.7 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.2 GO:0031083 BLOC-1 complex(GO:0031083)
0.0 1.0 GO:0042734 presynaptic membrane(GO:0042734)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.7 GO:0050436 microfibril binding(GO:0050436)
0.3 6.7 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.3 3.8 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.3 1.5 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.2 0.6 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.2 0.8 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.2 1.5 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.2 1.7 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.2 1.0 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.2 0.6 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.1 1.3 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 1.3 GO:0039706 co-receptor binding(GO:0039706)
0.1 1.3 GO:0070097 delta-catenin binding(GO:0070097)
0.1 1.9 GO:0070566 adenylyltransferase activity(GO:0070566)
0.1 0.3 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
0.1 0.6 GO:0051434 BH3 domain binding(GO:0051434)
0.1 0.5 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.1 1.7 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.1 0.5 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 2.8 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 1.6 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 0.7 GO:0050699 WW domain binding(GO:0050699)
0.0 1.1 GO:0005507 copper ion binding(GO:0005507)
0.0 1.4 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 1.0 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 2.7 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.6 GO:0015036 disulfide oxidoreductase activity(GO:0015036)
0.0 5.0 GO:0003924 GTPase activity(GO:0003924)
0.0 0.8 GO:0051082 unfolded protein binding(GO:0051082)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.7 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.1 3.9 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 4.0 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 4.7 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.6 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 0.5 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 1.3 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.2 2.8 REACTOME_NFKB_ACTIVATION_THROUGH_FADD_RIP1_PATHWAY_MEDIATED_BY_CASPASE_8_AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.1 1.7 REACTOME_REGULATION_OF_IFNG_SIGNALING Genes involved in Regulation of IFNG signaling
0.1 2.7 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.1 1.8 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 1.0 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 1.4 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.7 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.6 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions