Motif ID: Hoxb6

Z-value: 0.230


Transcription factors associated with Hoxb6:

Gene SymbolEntrez IDGene Name
Hoxb6 ENSMUSG00000000690.4 Hoxb6



Activity profile for motif Hoxb6.

activity profile for motif Hoxb6


Sorted Z-values histogram for motif Hoxb6

Sorted Z-values for motif Hoxb6



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb6

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_23248264 2.202 ENSMUST00000031709.5
Fezf1
Fez family zinc finger 1
chr4_+_15881255 0.596 ENSMUST00000029876.1
Calb1
calbindin 1
chr2_+_164769892 0.496 ENSMUST00000088248.6
ENSMUST00000001439.6
Ube2c

ubiquitin-conjugating enzyme E2C

chr10_-_64090265 0.460 ENSMUST00000105439.1
Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr8_-_105471481 0.451 ENSMUST00000014990.6
Tppp3
tubulin polymerization-promoting protein family member 3
chr9_-_70141484 0.351 ENSMUST00000034749.8
Fam81a
family with sequence similarity 81, member A
chr2_-_125859139 0.329 ENSMUST00000110463.1
ENSMUST00000028635.5
Cops2

COP9 (constitutive photomorphogenic) homolog, subunit 2 (Arabidopsis thaliana)

chr2_+_125859134 0.322 ENSMUST00000028636.6
ENSMUST00000125084.1
Galk2

galactokinase 2

chr5_+_88583527 0.320 ENSMUST00000031229.6
Rufy3
RUN and FYVE domain containing 3
chr6_+_142413441 0.307 ENSMUST00000088263.4
B230216G23Rik
RIKEN cDNA B230216G23 gene
chrX_-_143933204 0.295 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
Dcx


doublecortin


chr9_-_35570393 0.294 ENSMUST00000115110.4
Hyls1
hydrolethalus syndrome 1
chr6_-_3494587 0.287 ENSMUST00000049985.8
Hepacam2
HEPACAM family member 2
chr19_+_25406661 0.267 ENSMUST00000146647.1
Kank1
KN motif and ankyrin repeat domains 1
chr19_+_24875679 0.254 ENSMUST00000073080.5
Gm10053
predicted gene 10053
chrX_+_38600626 0.217 ENSMUST00000000365.2
Mcts1
malignant T cell amplified sequence 1
chr11_-_72215592 0.214 ENSMUST00000021157.8
Med31
mediator of RNA polymerase II transcription, subunit 31 homolog (yeast)
chr13_+_93304799 0.214 ENSMUST00000080127.5
Homer1
homer homolog 1 (Drosophila)
chr8_-_77610597 0.203 ENSMUST00000034030.8
Tmem184c
transmembrane protein 184C
chr11_-_74724670 0.200 ENSMUST00000021091.8
Pafah1b1
platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
chr8_-_54724474 0.188 ENSMUST00000175915.1
Wdr17
WD repeat domain 17
chr4_-_134853294 0.181 ENSMUST00000030628.8
Tmem57
transmembrane protein 57
chr2_+_29346803 0.177 ENSMUST00000028139.4
ENSMUST00000113830.4
Med27

mediator complex subunit 27

chr14_+_32599922 0.125 ENSMUST00000068938.5
Prrxl1
paired related homeobox protein-like 1
chr6_+_86371489 0.120 ENSMUST00000089558.5
Snrpg
small nuclear ribonucleoprotein polypeptide G
chr8_+_31111816 0.118 ENSMUST00000046941.7
Rnf122
ring finger protein 122
chr6_-_12109583 0.116 ENSMUST00000080891.5
Gm6578
predicted gene 6578
chr13_-_92030897 0.116 ENSMUST00000149630.1
Rasgrf2
RAS protein-specific guanine nucleotide-releasing factor 2
chrX_-_101222426 0.106 ENSMUST00000120389.1
ENSMUST00000156473.1
ENSMUST00000077876.3
Snx12


sorting nexin 12


chr7_+_51880312 0.106 ENSMUST00000145049.1
Gas2
growth arrest specific 2
chr3_-_119783262 0.101 ENSMUST00000029780.7
Ptbp2
polypyrimidine tract binding protein 2
chr19_-_6925367 0.100 ENSMUST00000057716.4
Tex40
testis expressed 40
chr13_+_93304066 0.097 ENSMUST00000109493.1
Homer1
homer homolog 1 (Drosophila)
chr9_+_92309362 0.095 ENSMUST00000098477.1
ENSMUST00000150594.1
1700057G04Rik

RIKEN cDNA 1700057G04 gene

chr6_-_52012476 0.089 ENSMUST00000078214.5
Skap2
src family associated phosphoprotein 2
chrX_-_8252304 0.084 ENSMUST00000115594.1
Ftsj1
FtsJ homolog 1 (E. coli)
chr3_+_94413244 0.084 ENSMUST00000166032.1
ENSMUST00000045245.5
Tdrkh

tudor and KH domain containing protein

chr12_+_103388656 0.069 ENSMUST00000101094.2
ENSMUST00000021620.6
Otub2

OTU domain, ubiquitin aldehyde binding 2

chr8_-_77610668 0.058 ENSMUST00000141202.1
ENSMUST00000152168.1
Tmem184c

transmembrane protein 184C

chrX_-_143933089 0.042 ENSMUST00000087313.3
Dcx
doublecortin
chr16_+_44347121 0.040 ENSMUST00000050897.6
Spice1
spindle and centriole associated protein 1
chr8_+_13435459 0.038 ENSMUST00000167071.1
ENSMUST00000167505.1
Tmem255b

transmembrane protein 255B

chr13_-_21810190 0.034 ENSMUST00000110469.1
ENSMUST00000091749.2
Hist1h2bq

histone cluster 1, H2bq

chr8_+_111033890 0.029 ENSMUST00000034441.7
Aars
alanyl-tRNA synthetase
chr5_+_31526989 0.029 ENSMUST00000114533.2
ENSMUST00000117262.1
ENSMUST00000117319.1
Slc4a1ap


solute carrier family 4 (anion exchanger), member 1, adaptor protein


chr10_-_39122277 0.025 ENSMUST00000136546.1
Fam229b
family with sequence similarity 229, member B
chr9_+_21955747 0.024 ENSMUST00000053583.5
Swsap1
SWIM type zinc finger 7 associated protein 1
chr13_+_58281183 0.011 ENSMUST00000180882.1
ENSMUST00000180452.1
Gm26555

predicted gene, 26555


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.2 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 0.6 GO:0072235 distal convoluted tubule development(GO:0072025) metanephric distal convoluted tubule development(GO:0072221) metanephric distal tubule development(GO:0072235)
0.1 0.5 GO:0010993 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.1 0.3 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.1 0.2 GO:0002188 translation reinitiation(GO:0002188)
0.0 0.2 GO:0051661 maintenance of centrosome location(GO:0051661)
0.0 0.1 GO:2000642 negative regulation of early endosome to late endosome transport(GO:2000642)
0.0 0.5 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.0 0.3 GO:0006012 galactose metabolic process(GO:0006012)
0.0 0.3 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 0.3 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 0.3 GO:0000338 protein deneddylation(GO:0000338)
0.0 0.3 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 0.1 GO:0034587 piRNA metabolic process(GO:0034587)
0.0 0.1 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 0.1 GO:0021559 trigeminal nerve development(GO:0021559)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0097427 microtubule bundle(GO:0097427)
0.0 0.2 GO:0000235 astral microtubule(GO:0000235)
0.0 0.2 GO:0070847 core mediator complex(GO:0070847)
0.0 0.2 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.0 0.3 GO:0071437 invadopodium(GO:0071437)
0.0 0.5 GO:0005680 anaphase-promoting complex(GO:0005680)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0004335 galactokinase activity(GO:0004335)
0.0 0.3 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 0.1 GO:1990446 U1 snRNP binding(GO:1990446)
0.0 0.1 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 2.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase