Motif ID: Irf2_Irf1_Irf8_Irf9_Irf7
Z-value: 3.727





Transcription factors associated with Irf2_Irf1_Irf8_Irf9_Irf7:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Irf1 | ENSMUSG00000018899.10 | Irf1 |
Irf2 | ENSMUSG00000031627.7 | Irf2 |
Irf7 | ENSMUSG00000025498.8 | Irf7 |
Irf8 | ENSMUSG00000041515.3 | Irf8 |
Irf9 | ENSMUSG00000002325.8 | Irf9 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Irf1 | mm10_v2_chr11_+_53770458_53770509 | 0.64 | 7.7e-06 | Click! |
Irf8 | mm10_v2_chr8_+_120736352_120736385 | 0.33 | 3.3e-02 | Click! |
Irf2 | mm10_v2_chr8_+_46739745_46739791 | 0.32 | 4.1e-02 | Click! |
Irf9 | mm10_v2_chr14_+_55604550_55604579 | -0.26 | 1.0e-01 | Click! |
Irf7 | mm10_v2_chr7_-_141266415_141266481 | -0.07 | 6.7e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
7.4 | 22.3 | GO:0045349 | interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) |
4.6 | 45.6 | GO:0060330 | regulation of response to interferon-gamma(GO:0060330) |
3.6 | 14.4 | GO:0034759 | regulation of iron ion transport(GO:0034756) regulation of iron ion transmembrane transport(GO:0034759) |
2.3 | 9.2 | GO:0009597 | detection of virus(GO:0009597) |
2.1 | 10.5 | GO:1900170 | negative regulation of glucocorticoid mediated signaling pathway(GO:1900170) |
2.1 | 6.3 | GO:0014809 | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809) |
1.9 | 1.9 | GO:0002481 | antigen processing and presentation of exogenous peptide antigen via MHC class Ib(GO:0002477) antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent(GO:0002481) |
1.9 | 5.6 | GO:1904139 | microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139) |
1.8 | 5.4 | GO:0006059 | hexitol metabolic process(GO:0006059) alditol biosynthetic process(GO:0019401) |
1.8 | 7.1 | GO:1902990 | leading strand elongation(GO:0006272) mitotic telomere maintenance via semi-conservative replication(GO:1902990) |
1.7 | 7.0 | GO:0002484 | antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway(GO:0002484) antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent(GO:0002485) |
1.5 | 16.6 | GO:2000051 | negative regulation of non-canonical Wnt signaling pathway(GO:2000051) |
1.5 | 11.8 | GO:0048625 | myoblast fate commitment(GO:0048625) |
1.5 | 4.4 | GO:0042097 | interleukin-4 biosynthetic process(GO:0042097) regulation of interleukin-4 biosynthetic process(GO:0045402) |
1.5 | 10.3 | GO:0043569 | negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569) |
1.5 | 7.3 | GO:0019885 | antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885) |
1.5 | 8.7 | GO:0046598 | positive regulation of viral entry into host cell(GO:0046598) |
1.4 | 4.1 | GO:0097350 | neutrophil clearance(GO:0097350) |
1.3 | 4.0 | GO:0060364 | frontal suture morphogenesis(GO:0060364) |
1.3 | 5.3 | GO:1904565 | response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566) |
1.3 | 10.0 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
1.1 | 3.3 | GO:0097026 | dendritic cell dendrite assembly(GO:0097026) |
1.1 | 8.6 | GO:0090336 | positive regulation of brown fat cell differentiation(GO:0090336) |
1.0 | 2.9 | GO:0051754 | meiotic sister chromatid cohesion, centromeric(GO:0051754) |
0.9 | 3.6 | GO:0030091 | protein repair(GO:0030091) |
0.9 | 4.4 | GO:0080184 | response to stilbenoid(GO:0035634) response to phenylpropanoid(GO:0080184) |
0.8 | 8.5 | GO:1900225 | NLRP3 inflammasome complex assembly(GO:0044546) regulation of NLRP3 inflammasome complex assembly(GO:1900225) |
0.8 | 3.3 | GO:1903416 | negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137) regulation of calcidiol 1-monooxygenase activity(GO:0060558) response to glycoside(GO:1903416) |
0.8 | 4.1 | GO:0045918 | negative regulation of cytolysis(GO:0045918) |
0.8 | 3.9 | GO:0034421 | post-translational protein acetylation(GO:0034421) |
0.8 | 3.0 | GO:0072592 | regulation of integrin biosynthetic process(GO:0045113) oxygen metabolic process(GO:0072592) |
0.7 | 2.2 | GO:0019441 | tryptophan catabolic process(GO:0006569) tryptophan catabolic process to kynurenine(GO:0019441) quinolinate biosynthetic process(GO:0019805) indole-containing compound catabolic process(GO:0042436) indolalkylamine catabolic process(GO:0046218) kynurenine metabolic process(GO:0070189) |
0.7 | 2.1 | GO:0048687 | positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) |
0.7 | 1.3 | GO:0009814 | defense response, incompatible interaction(GO:0009814) |
0.7 | 2.7 | GO:2000313 | fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313) |
0.7 | 2.0 | GO:0006553 | lysine metabolic process(GO:0006553) |
0.6 | 1.9 | GO:1903225 | negative regulation of endodermal cell differentiation(GO:1903225) |
0.6 | 2.5 | GO:0046947 | hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947) |
0.6 | 3.1 | GO:0090669 | snoRNA guided rRNA pseudouridine synthesis(GO:0000454) telomerase RNA stabilization(GO:0090669) |
0.6 | 3.6 | GO:0032196 | regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196) |
0.6 | 1.8 | GO:0060745 | mammary gland branching involved in pregnancy(GO:0060745) |
0.6 | 9.2 | GO:1902187 | negative regulation of viral release from host cell(GO:1902187) |
0.5 | 0.5 | GO:0071336 | regulation of hair follicle cell proliferation(GO:0071336) positive regulation of hair follicle cell proliferation(GO:0071338) |
0.5 | 4.3 | GO:1900262 | regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264) |
0.5 | 1.6 | GO:1905203 | regulation of connective tissue replacement(GO:1905203) |
0.5 | 1.5 | GO:0035441 | cell migration involved in vasculogenesis(GO:0035441) metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262) |
0.5 | 1.4 | GO:1904879 | positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879) |
0.5 | 1.4 | GO:0090289 | regulation of osteoclast proliferation(GO:0090289) |
0.5 | 1.4 | GO:0033566 | gamma-tubulin complex localization(GO:0033566) |
0.5 | 1.8 | GO:0006447 | regulation of translational initiation by iron(GO:0006447) positive regulation of translational initiation by iron(GO:0045994) |
0.5 | 3.2 | GO:0060762 | regulation of branching involved in mammary gland duct morphogenesis(GO:0060762) |
0.4 | 1.3 | GO:0044778 | meiotic DNA integrity checkpoint(GO:0044778) |
0.4 | 1.6 | GO:0006982 | response to lipid hydroperoxide(GO:0006982) cellular response to lipid hydroperoxide(GO:0071449) |
0.4 | 1.2 | GO:1902202 | regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202) |
0.4 | 1.9 | GO:1904721 | regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721) |
0.4 | 3.8 | GO:0032488 | Cdc42 protein signal transduction(GO:0032488) |
0.4 | 0.7 | GO:0003274 | endocardial cushion fusion(GO:0003274) |
0.4 | 0.7 | GO:0060700 | regulation of ribonuclease activity(GO:0060700) |
0.4 | 3.3 | GO:0046826 | negative regulation of protein export from nucleus(GO:0046826) |
0.4 | 1.1 | GO:0014891 | striated muscle atrophy(GO:0014891) |
0.4 | 2.5 | GO:1990504 | dense core granule exocytosis(GO:1990504) |
0.3 | 1.0 | GO:0072092 | ureteric bud invasion(GO:0072092) |
0.3 | 1.7 | GO:0042758 | long-chain fatty acid catabolic process(GO:0042758) |
0.3 | 1.0 | GO:0061537 | glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537) |
0.3 | 1.0 | GO:0045014 | detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) detection of glucose(GO:0051594) |
0.3 | 3.4 | GO:0032876 | negative regulation of DNA endoreduplication(GO:0032876) |
0.3 | 1.3 | GO:1903463 | regulation of mitotic cell cycle DNA replication(GO:1903463) |
0.3 | 4.9 | GO:0051639 | actin filament network formation(GO:0051639) |
0.3 | 0.6 | GO:1903719 | regulation of I-kappaB phosphorylation(GO:1903719) positive regulation of I-kappaB phosphorylation(GO:1903721) |
0.3 | 2.4 | GO:0051151 | negative regulation of smooth muscle cell differentiation(GO:0051151) |
0.3 | 1.2 | GO:0006420 | arginyl-tRNA aminoacylation(GO:0006420) |
0.3 | 6.5 | GO:0044458 | motile cilium assembly(GO:0044458) |
0.3 | 5.3 | GO:0021684 | cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707) |
0.3 | 1.2 | GO:0015889 | cobalamin transport(GO:0015889) |
0.3 | 2.0 | GO:0019532 | oxalate transport(GO:0019532) |
0.3 | 1.4 | GO:0007089 | traversing start control point of mitotic cell cycle(GO:0007089) |
0.3 | 2.0 | GO:0044838 | cell quiescence(GO:0044838) |
0.3 | 1.1 | GO:1903237 | negative regulation of leukocyte tethering or rolling(GO:1903237) |
0.3 | 1.4 | GO:0032497 | detection of lipopolysaccharide(GO:0032497) |
0.3 | 2.1 | GO:0010032 | meiotic chromosome condensation(GO:0010032) |
0.3 | 1.0 | GO:0097211 | prolactin secretion(GO:0070459) response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211) |
0.3 | 2.1 | GO:0070141 | response to UV-A(GO:0070141) |
0.3 | 3.3 | GO:0034219 | carbohydrate transmembrane transport(GO:0034219) |
0.3 | 11.0 | GO:0010390 | histone monoubiquitination(GO:0010390) |
0.2 | 7.1 | GO:0006379 | mRNA cleavage(GO:0006379) |
0.2 | 2.0 | GO:0060842 | arterial endothelial cell differentiation(GO:0060842) |
0.2 | 1.2 | GO:0010701 | positive regulation of norepinephrine secretion(GO:0010701) |
0.2 | 1.7 | GO:0042095 | interferon-gamma biosynthetic process(GO:0042095) |
0.2 | 0.7 | GO:1902071 | regulation of hypoxia-inducible factor-1alpha signaling pathway(GO:1902071) |
0.2 | 0.9 | GO:0006244 | pyrimidine nucleotide catabolic process(GO:0006244) pyrimidine deoxyribonucleotide catabolic process(GO:0009223) |
0.2 | 0.7 | GO:2000383 | regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384) |
0.2 | 4.9 | GO:0038092 | nodal signaling pathway(GO:0038092) |
0.2 | 1.1 | GO:0048852 | diencephalon morphogenesis(GO:0048852) |
0.2 | 0.7 | GO:0048698 | negative regulation of collateral sprouting in absence of injury(GO:0048698) |
0.2 | 0.9 | GO:2000676 | positive regulation of type B pancreatic cell apoptotic process(GO:2000676) |
0.2 | 1.1 | GO:0010940 | positive regulation of necrotic cell death(GO:0010940) |
0.2 | 0.6 | GO:0038018 | Wnt receptor catabolic process(GO:0038018) |
0.2 | 5.4 | GO:0097150 | neuronal stem cell population maintenance(GO:0097150) |
0.2 | 0.8 | GO:0032901 | positive regulation of neurotrophin production(GO:0032901) |
0.2 | 1.2 | GO:0042795 | snRNA transcription from RNA polymerase II promoter(GO:0042795) |
0.2 | 0.8 | GO:1903377 | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377) |
0.2 | 1.0 | GO:0070460 | thyroid-stimulating hormone secretion(GO:0070460) |
0.2 | 0.2 | GO:1904959 | regulation of electron carrier activity(GO:1904732) regulation of cytochrome-c oxidase activity(GO:1904959) |
0.2 | 0.8 | GO:1902626 | assembly of large subunit precursor of preribosome(GO:1902626) |
0.2 | 1.4 | GO:0036265 | RNA (guanine-N7)-methylation(GO:0036265) |
0.2 | 0.5 | GO:2000659 | regulation of interleukin-1-mediated signaling pathway(GO:2000659) |
0.2 | 0.9 | GO:0051026 | chiasma assembly(GO:0051026) |
0.2 | 0.9 | GO:0002121 | inter-male aggressive behavior(GO:0002121) |
0.2 | 0.5 | GO:0000966 | RNA 5'-end processing(GO:0000966) |
0.2 | 1.1 | GO:0003383 | apical constriction(GO:0003383) |
0.2 | 0.7 | GO:0051490 | negative regulation of filopodium assembly(GO:0051490) |
0.2 | 1.0 | GO:0006108 | malate metabolic process(GO:0006108) |
0.2 | 2.2 | GO:1904667 | negative regulation of ubiquitin protein ligase activity(GO:1904667) |
0.2 | 0.8 | GO:2000623 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623) |
0.2 | 0.3 | GO:0045359 | positive regulation of interferon-beta biosynthetic process(GO:0045359) |
0.2 | 0.7 | GO:0072602 | interleukin-4 secretion(GO:0072602) |
0.2 | 0.8 | GO:0060665 | regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665) |
0.2 | 0.5 | GO:1902498 | regulation of protein autoubiquitination(GO:1902498) |
0.2 | 0.5 | GO:0032687 | negative regulation of interferon-alpha production(GO:0032687) |
0.2 | 0.8 | GO:0035989 | tendon development(GO:0035989) |
0.2 | 0.3 | GO:0002765 | immune response-inhibiting signal transduction(GO:0002765) |
0.2 | 1.3 | GO:0036462 | TRAIL-activated apoptotic signaling pathway(GO:0036462) |
0.2 | 1.1 | GO:0010992 | ubiquitin homeostasis(GO:0010992) |
0.2 | 5.0 | GO:0034723 | DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723) |
0.2 | 0.5 | GO:2001180 | negative regulation of interleukin-10 secretion(GO:2001180) |
0.2 | 1.0 | GO:0044375 | regulation of peroxisome size(GO:0044375) |
0.2 | 1.6 | GO:2000781 | positive regulation of double-strand break repair(GO:2000781) |
0.2 | 1.5 | GO:0006271 | DNA strand elongation involved in DNA replication(GO:0006271) |
0.2 | 1.1 | GO:0005981 | regulation of glycogen catabolic process(GO:0005981) |
0.1 | 0.4 | GO:0007290 | spermatid nucleus elongation(GO:0007290) |
0.1 | 0.6 | GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590) |
0.1 | 0.6 | GO:1990481 | mRNA pseudouridine synthesis(GO:1990481) |
0.1 | 0.7 | GO:0046501 | protoporphyrinogen IX metabolic process(GO:0046501) |
0.1 | 1.0 | GO:0032534 | regulation of microvillus assembly(GO:0032534) |
0.1 | 1.6 | GO:2000741 | positive regulation of mesenchymal stem cell differentiation(GO:2000741) |
0.1 | 0.6 | GO:0090235 | regulation of metaphase plate congression(GO:0090235) |
0.1 | 2.7 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
0.1 | 5.0 | GO:0046825 | regulation of protein export from nucleus(GO:0046825) |
0.1 | 0.4 | GO:0002302 | CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302) |
0.1 | 0.4 | GO:0071918 | urea transmembrane transport(GO:0071918) |
0.1 | 1.0 | GO:0046851 | negative regulation of bone resorption(GO:0045779) negative regulation of bone remodeling(GO:0046851) |
0.1 | 0.6 | GO:0060594 | mammary gland specification(GO:0060594) |
0.1 | 0.5 | GO:0043328 | protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328) |
0.1 | 1.3 | GO:0046597 | negative regulation of viral entry into host cell(GO:0046597) |
0.1 | 2.6 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
0.1 | 1.2 | GO:0006450 | regulation of translational fidelity(GO:0006450) |
0.1 | 1.1 | GO:0071360 | cellular response to exogenous dsRNA(GO:0071360) |
0.1 | 0.4 | GO:0071211 | protein targeting to vacuole involved in autophagy(GO:0071211) |
0.1 | 0.4 | GO:1901098 | positive regulation of autophagosome maturation(GO:1901098) |
0.1 | 0.9 | GO:0032836 | glomerular basement membrane development(GO:0032836) |
0.1 | 0.7 | GO:0051096 | regulation of helicase activity(GO:0051095) positive regulation of helicase activity(GO:0051096) |
0.1 | 0.7 | GO:0072086 | specification of loop of Henle identity(GO:0072086) |
0.1 | 0.1 | GO:0002489 | antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) |
0.1 | 12.9 | GO:0010811 | positive regulation of cell-substrate adhesion(GO:0010811) |
0.1 | 0.5 | GO:0046654 | 'de novo' IMP biosynthetic process(GO:0006189) tetrahydrofolate biosynthetic process(GO:0046654) |
0.1 | 1.6 | GO:0045292 | mRNA cis splicing, via spliceosome(GO:0045292) |
0.1 | 1.3 | GO:0000212 | meiotic spindle organization(GO:0000212) meiotic chromosome separation(GO:0051307) |
0.1 | 1.5 | GO:0042759 | long-chain fatty acid biosynthetic process(GO:0042759) |
0.1 | 1.8 | GO:0035458 | cellular response to interferon-beta(GO:0035458) |
0.1 | 0.2 | GO:0051771 | negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771) |
0.1 | 0.6 | GO:0048304 | positive regulation of isotype switching to IgG isotypes(GO:0048304) |
0.1 | 1.0 | GO:0070932 | histone H3 deacetylation(GO:0070932) |
0.1 | 1.1 | GO:0046784 | viral mRNA export from host cell nucleus(GO:0046784) |
0.1 | 1.2 | GO:0072112 | renal filtration cell differentiation(GO:0061318) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311) |
0.1 | 0.3 | GO:0017185 | peptidyl-lysine hydroxylation(GO:0017185) |
0.1 | 0.3 | GO:1902031 | regulation of pentose-phosphate shunt(GO:0043456) regulation of NADP metabolic process(GO:1902031) |
0.1 | 1.2 | GO:0090435 | protein localization to nuclear envelope(GO:0090435) |
0.1 | 1.1 | GO:0006388 | tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388) |
0.1 | 0.5 | GO:0006048 | glucosamine metabolic process(GO:0006041) UDP-N-acetylglucosamine biosynthetic process(GO:0006048) |
0.1 | 0.3 | GO:1904742 | regulation of telomeric DNA binding(GO:1904742) |
0.1 | 1.4 | GO:1904293 | negative regulation of ERAD pathway(GO:1904293) |
0.1 | 3.2 | GO:0046677 | response to antibiotic(GO:0046677) |
0.1 | 1.5 | GO:1902857 | positive regulation of nonmotile primary cilium assembly(GO:1902857) |
0.1 | 0.2 | GO:0090365 | regulation of mRNA modification(GO:0090365) |
0.1 | 0.4 | GO:1902965 | regulation of protein localization to early endosome(GO:1902965) positive regulation of protein localization to early endosome(GO:1902966) |
0.1 | 0.6 | GO:0017196 | N-terminal peptidyl-methionine acetylation(GO:0017196) |
0.1 | 0.3 | GO:0002036 | regulation of L-glutamate transport(GO:0002036) |
0.1 | 1.2 | GO:0042407 | cristae formation(GO:0042407) |
0.1 | 0.2 | GO:0060333 | interferon-gamma-mediated signaling pathway(GO:0060333) |
0.1 | 0.2 | GO:0090272 | negative regulation of fibroblast growth factor production(GO:0090272) |
0.1 | 0.4 | GO:0045213 | neurotransmitter receptor metabolic process(GO:0045213) |
0.1 | 1.0 | GO:0031274 | positive regulation of pseudopodium assembly(GO:0031274) |
0.1 | 2.8 | GO:0071346 | cellular response to interferon-gamma(GO:0071346) |
0.1 | 0.2 | GO:1903588 | negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588) |
0.1 | 0.5 | GO:1990928 | response to amino acid starvation(GO:1990928) |
0.1 | 0.3 | GO:0035878 | nail development(GO:0035878) |
0.1 | 0.5 | GO:0032782 | bile acid secretion(GO:0032782) |
0.1 | 0.9 | GO:0033234 | negative regulation of protein sumoylation(GO:0033234) |
0.1 | 0.9 | GO:0043984 | histone H4-K16 acetylation(GO:0043984) |
0.1 | 0.2 | GO:0018298 | protein-chromophore linkage(GO:0018298) |
0.1 | 2.5 | GO:0035082 | axoneme assembly(GO:0035082) |
0.1 | 2.9 | GO:0042733 | embryonic digit morphogenesis(GO:0042733) |
0.1 | 0.4 | GO:0021796 | cerebral cortex regionalization(GO:0021796) |
0.1 | 0.4 | GO:0019240 | citrulline biosynthetic process(GO:0019240) |
0.1 | 1.3 | GO:0016180 | snRNA processing(GO:0016180) |
0.1 | 3.1 | GO:0005978 | glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250) |
0.1 | 0.9 | GO:0038063 | collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) |
0.1 | 0.1 | GO:0071169 | establishment of protein localization to chromatin(GO:0071169) |
0.1 | 0.4 | GO:0019348 | dolichol metabolic process(GO:0019348) |
0.1 | 0.6 | GO:0045899 | positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899) |
0.1 | 0.4 | GO:0048251 | elastic fiber assembly(GO:0048251) |
0.1 | 0.2 | GO:0016554 | cytidine to uridine editing(GO:0016554) |
0.1 | 0.4 | GO:0018026 | peptidyl-lysine monomethylation(GO:0018026) |
0.1 | 0.1 | GO:0090202 | transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579) |
0.1 | 2.0 | GO:0006270 | DNA replication initiation(GO:0006270) |
0.1 | 0.2 | GO:0000821 | regulation of arginine metabolic process(GO:0000821) |
0.0 | 0.8 | GO:0009083 | branched-chain amino acid catabolic process(GO:0009083) |
0.0 | 0.9 | GO:0030575 | nuclear body organization(GO:0030575) |
0.0 | 1.1 | GO:0035067 | negative regulation of histone acetylation(GO:0035067) |
0.0 | 0.1 | GO:0032474 | otolith morphogenesis(GO:0032474) |
0.0 | 0.1 | GO:0061357 | Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) positive regulation of Wnt protein secretion(GO:0061357) |
0.0 | 0.4 | GO:0030539 | male genitalia development(GO:0030539) |
0.0 | 0.7 | GO:0051984 | positive regulation of chromosome segregation(GO:0051984) |
0.0 | 3.6 | GO:0061077 | chaperone-mediated protein folding(GO:0061077) |
0.0 | 1.0 | GO:0006491 | N-glycan processing(GO:0006491) |
0.0 | 0.4 | GO:1903608 | protein localization to cytoplasmic stress granule(GO:1903608) |
0.0 | 0.9 | GO:0030225 | macrophage differentiation(GO:0030225) |
0.0 | 1.6 | GO:0035019 | somatic stem cell population maintenance(GO:0035019) |
0.0 | 0.7 | GO:0000271 | polysaccharide biosynthetic process(GO:0000271) |
0.0 | 0.2 | GO:0031666 | positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666) |
0.0 | 0.2 | GO:0021678 | third ventricle development(GO:0021678) |
0.0 | 1.9 | GO:0015914 | phospholipid transport(GO:0015914) |
0.0 | 0.1 | GO:0036151 | phosphatidylcholine acyl-chain remodeling(GO:0036151) |
0.0 | 0.4 | GO:0032486 | Rap protein signal transduction(GO:0032486) |
0.0 | 0.3 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
0.0 | 1.0 | GO:0048662 | negative regulation of smooth muscle cell proliferation(GO:0048662) |
0.0 | 0.5 | GO:0010592 | positive regulation of lamellipodium assembly(GO:0010592) |
0.0 | 3.1 | GO:0019395 | fatty acid oxidation(GO:0019395) |
0.0 | 0.4 | GO:0034497 | protein localization to pre-autophagosomal structure(GO:0034497) |
0.0 | 0.5 | GO:0050774 | negative regulation of dendrite morphogenesis(GO:0050774) |
0.0 | 0.2 | GO:0000492 | box C/D snoRNP assembly(GO:0000492) |
0.0 | 0.2 | GO:0043011 | myeloid dendritic cell differentiation(GO:0043011) |
0.0 | 0.5 | GO:0030150 | protein import into mitochondrial matrix(GO:0030150) |
0.0 | 0.3 | GO:0009062 | fatty acid catabolic process(GO:0009062) |
0.0 | 0.9 | GO:0050829 | defense response to Gram-negative bacterium(GO:0050829) |
0.0 | 0.1 | GO:0051342 | regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051342) negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344) |
0.0 | 0.2 | GO:0070914 | UV-damage excision repair(GO:0070914) |
0.0 | 0.2 | GO:1901162 | serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162) |
0.0 | 0.1 | GO:0000957 | mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960) mitochondrial RNA 3'-end processing(GO:0000965) |
0.0 | 0.2 | GO:1901837 | negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837) |
0.0 | 0.1 | GO:0060576 | intestinal epithelial cell development(GO:0060576) |
0.0 | 0.2 | GO:0006390 | transcription from mitochondrial promoter(GO:0006390) |
0.0 | 0.6 | GO:0090200 | positive regulation of release of cytochrome c from mitochondria(GO:0090200) |
0.0 | 3.2 | GO:0048814 | regulation of dendrite morphogenesis(GO:0048814) |
0.0 | 2.1 | GO:0032092 | positive regulation of protein binding(GO:0032092) |
0.0 | 0.2 | GO:2000194 | regulation of female gonad development(GO:2000194) |
0.0 | 0.3 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
0.0 | 0.1 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
0.0 | 0.1 | GO:0030502 | negative regulation of bone mineralization(GO:0030502) |
0.0 | 0.2 | GO:0060124 | positive regulation of growth hormone secretion(GO:0060124) |
0.0 | 0.4 | GO:1903963 | arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963) |
0.0 | 0.5 | GO:0044783 | mitotic G1 DNA damage checkpoint(GO:0031571) G1 DNA damage checkpoint(GO:0044783) |
0.0 | 0.3 | GO:0007096 | regulation of exit from mitosis(GO:0007096) uterus development(GO:0060065) |
0.0 | 0.1 | GO:0006207 | 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856) |
0.0 | 0.1 | GO:0033030 | negative regulation of neutrophil apoptotic process(GO:0033030) |
0.0 | 0.4 | GO:0055012 | ventricular cardiac muscle cell differentiation(GO:0055012) |
0.0 | 0.2 | GO:0016926 | protein desumoylation(GO:0016926) |
0.0 | 0.0 | GO:0032380 | regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383) |
0.0 | 0.1 | GO:0046098 | guanine metabolic process(GO:0046098) |
0.0 | 5.1 | GO:0043010 | camera-type eye development(GO:0043010) |
0.0 | 0.2 | GO:0001682 | tRNA 5'-leader removal(GO:0001682) |
0.0 | 0.1 | GO:0002314 | germinal center B cell differentiation(GO:0002314) |
0.0 | 0.2 | GO:0000291 | nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291) |
0.0 | 0.9 | GO:0001654 | eye development(GO:0001654) |
0.0 | 0.6 | GO:0048025 | negative regulation of mRNA splicing, via spliceosome(GO:0048025) |
0.0 | 0.4 | GO:0046718 | viral entry into host cell(GO:0046718) |
0.0 | 0.1 | GO:1990403 | embryonic brain development(GO:1990403) |
0.0 | 1.7 | GO:0048706 | embryonic skeletal system development(GO:0048706) |
0.0 | 0.6 | GO:0000462 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462) |
0.0 | 0.1 | GO:0042574 | isoprenoid catabolic process(GO:0008300) retinal metabolic process(GO:0042574) |
0.0 | 0.2 | GO:0071578 | zinc II ion transmembrane import(GO:0071578) |
0.0 | 0.1 | GO:0006624 | vacuolar protein processing(GO:0006624) |
0.0 | 0.5 | GO:0010107 | potassium ion import(GO:0010107) |
0.0 | 1.7 | GO:0002244 | hematopoietic progenitor cell differentiation(GO:0002244) |
0.0 | 0.4 | GO:0031365 | N-terminal protein amino acid modification(GO:0031365) |
0.0 | 0.8 | GO:0006278 | RNA-dependent DNA biosynthetic process(GO:0006278) telomere maintenance via telomerase(GO:0007004) |
0.0 | 0.0 | GO:0015867 | ATP transport(GO:0015867) |
0.0 | 0.3 | GO:0007094 | mitotic spindle assembly checkpoint(GO:0007094) spindle assembly checkpoint(GO:0071173) |
0.0 | 0.2 | GO:0035090 | maintenance of apical/basal cell polarity(GO:0035090) |
0.0 | 0.1 | GO:0097428 | protein maturation by iron-sulfur cluster transfer(GO:0097428) |
0.0 | 1.9 | GO:0008360 | regulation of cell shape(GO:0008360) |
0.0 | 0.1 | GO:0090003 | regulation of Golgi to plasma membrane protein transport(GO:0042996) regulation of establishment of protein localization to plasma membrane(GO:0090003) |
0.0 | 0.5 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
0.0 | 0.9 | GO:0051453 | regulation of intracellular pH(GO:0051453) |
0.0 | 0.8 | GO:0001843 | neural tube closure(GO:0001843) tube closure(GO:0060606) |
0.0 | 0.1 | GO:0042572 | retinol metabolic process(GO:0042572) |
0.0 | 169.4 | GO:0008150 | biological_process(GO:0008150) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.4 | 7.1 | GO:0070557 | PCNA-p21 complex(GO:0070557) |
2.3 | 27.1 | GO:0042612 | MHC class I protein complex(GO:0042612) |
1.8 | 5.3 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
1.4 | 5.4 | GO:0097454 | Schwann cell microvillus(GO:0097454) |
1.3 | 11.8 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) |
1.0 | 4.0 | GO:0032127 | dense core granule membrane(GO:0032127) |
0.9 | 14.7 | GO:0005614 | interstitial matrix(GO:0005614) |
0.9 | 13.0 | GO:0044754 | secondary lysosome(GO:0005767) autolysosome(GO:0044754) |
0.8 | 4.2 | GO:1990462 | omegasome(GO:1990462) |
0.8 | 3.1 | GO:0090661 | box H/ACA telomerase RNP complex(GO:0090661) |
0.8 | 3.0 | GO:0071438 | invadopodium membrane(GO:0071438) |
0.7 | 4.3 | GO:0005663 | DNA replication factor C complex(GO:0005663) |
0.6 | 1.9 | GO:0005588 | collagen type V trimer(GO:0005588) |
0.6 | 2.8 | GO:1990357 | terminal web(GO:1990357) |
0.5 | 3.3 | GO:0070531 | BRCA1-A complex(GO:0070531) |
0.5 | 1.6 | GO:0097058 | CRLF-CLCF1 complex(GO:0097058) |
0.5 | 1.6 | GO:0030690 | Noc1p-Noc2p complex(GO:0030690) |
0.5 | 1.5 | GO:0043625 | delta DNA polymerase complex(GO:0043625) |
0.5 | 3.3 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
0.4 | 2.9 | GO:0042825 | TAP complex(GO:0042825) |
0.4 | 1.6 | GO:0031084 | BLOC-2 complex(GO:0031084) |
0.4 | 2.8 | GO:0030915 | Smc5-Smc6 complex(GO:0030915) |
0.4 | 6.0 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
0.4 | 4.1 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
0.4 | 1.4 | GO:0031233 | intrinsic component of external side of plasma membrane(GO:0031233) |
0.3 | 4.8 | GO:0035631 | CD40 receptor complex(GO:0035631) |
0.3 | 4.0 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
0.3 | 3.9 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
0.3 | 4.7 | GO:0065010 | extracellular membrane-bounded organelle(GO:0065010) |
0.3 | 20.4 | GO:0031519 | PcG protein complex(GO:0031519) |
0.3 | 1.4 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
0.3 | 1.4 | GO:0043527 | tRNA methyltransferase complex(GO:0043527) |
0.3 | 2.1 | GO:0042611 | MHC protein complex(GO:0042611) |
0.3 | 1.8 | GO:0097550 | transcriptional preinitiation complex(GO:0097550) |
0.3 | 2.0 | GO:0001520 | outer dense fiber(GO:0001520) |
0.2 | 0.9 | GO:0002111 | BRCA2-BRAF35 complex(GO:0002111) |
0.2 | 2.1 | GO:0000796 | condensin complex(GO:0000796) |
0.2 | 2.1 | GO:0030478 | actin cap(GO:0030478) |
0.2 | 0.9 | GO:0031265 | CD95 death-inducing signaling complex(GO:0031265) |
0.2 | 0.9 | GO:0097450 | astrocyte end-foot(GO:0097450) |
0.2 | 1.3 | GO:0030896 | checkpoint clamp complex(GO:0030896) |
0.2 | 0.8 | GO:0005947 | mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) |
0.2 | 1.5 | GO:0031105 | septin complex(GO:0031105) |
0.2 | 9.7 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
0.2 | 0.9 | GO:0072487 | MSL complex(GO:0072487) |
0.2 | 0.9 | GO:0005587 | collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651) |
0.2 | 0.5 | GO:0000814 | ESCRT II complex(GO:0000814) |
0.2 | 2.4 | GO:0042555 | MCM complex(GO:0042555) |
0.2 | 0.8 | GO:0042406 | extrinsic component of endoplasmic reticulum membrane(GO:0042406) |
0.2 | 1.1 | GO:0072357 | PTW/PP1 phosphatase complex(GO:0072357) |
0.2 | 6.8 | GO:0016235 | aggresome(GO:0016235) |
0.1 | 1.4 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
0.1 | 1.7 | GO:0043657 | host(GO:0018995) host cell part(GO:0033643) host cell(GO:0043657) |
0.1 | 1.2 | GO:0061617 | MICOS complex(GO:0061617) |
0.1 | 1.1 | GO:0033269 | internode region of axon(GO:0033269) |
0.1 | 1.7 | GO:0031597 | cytosolic proteasome complex(GO:0031597) |
0.1 | 0.7 | GO:0045179 | apical cortex(GO:0045179) |
0.1 | 11.6 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
0.1 | 0.8 | GO:0005638 | lamin filament(GO:0005638) |
0.1 | 1.1 | GO:0000347 | THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) |
0.1 | 0.5 | GO:0044327 | dendritic spine head(GO:0044327) |
0.1 | 1.1 | GO:0072669 | tRNA-splicing ligase complex(GO:0072669) |
0.1 | 0.8 | GO:0042382 | paraspeckles(GO:0042382) |
0.1 | 0.4 | GO:0033185 | dolichol-phosphate-mannose synthase complex(GO:0033185) |
0.1 | 1.2 | GO:1990635 | proximal dendrite(GO:1990635) |
0.1 | 0.8 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
0.1 | 0.3 | GO:0005577 | fibrinogen complex(GO:0005577) |
0.1 | 3.5 | GO:0016592 | mediator complex(GO:0016592) |
0.1 | 1.3 | GO:0032039 | integrator complex(GO:0032039) |
0.1 | 0.8 | GO:0043240 | Fanconi anaemia nuclear complex(GO:0043240) |
0.1 | 1.5 | GO:0031616 | spindle pole centrosome(GO:0031616) |
0.1 | 0.4 | GO:0034388 | Pwp2p-containing subcomplex of 90S preribosome(GO:0034388) |
0.1 | 0.7 | GO:0045298 | tubulin complex(GO:0045298) |
0.1 | 1.0 | GO:0005922 | connexon complex(GO:0005922) |
0.1 | 0.3 | GO:0005784 | Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256) |
0.1 | 5.8 | GO:0036126 | sperm flagellum(GO:0036126) |
0.1 | 5.2 | GO:0005604 | basement membrane(GO:0005604) |
0.1 | 9.1 | GO:0005923 | bicellular tight junction(GO:0005923) |
0.1 | 0.4 | GO:0097165 | nuclear stress granule(GO:0097165) |
0.1 | 1.8 | GO:0034451 | centriolar satellite(GO:0034451) |
0.1 | 0.8 | GO:0045120 | pronucleus(GO:0045120) |
0.1 | 0.5 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
0.1 | 0.5 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
0.1 | 0.5 | GO:0005850 | eukaryotic translation initiation factor 2 complex(GO:0005850) |
0.1 | 0.8 | GO:0030126 | COPI vesicle coat(GO:0030126) |
0.1 | 1.8 | GO:0000788 | nuclear nucleosome(GO:0000788) |
0.1 | 0.7 | GO:0031462 | Cul2-RING ubiquitin ligase complex(GO:0031462) |
0.1 | 2.0 | GO:0032590 | dendrite membrane(GO:0032590) |
0.1 | 0.7 | GO:0010369 | chromocenter(GO:0010369) |
0.1 | 1.7 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
0.0 | 0.6 | GO:0000177 | cytoplasmic exosome (RNase complex)(GO:0000177) |
0.0 | 0.7 | GO:0042405 | nuclear inclusion body(GO:0042405) |
0.0 | 0.6 | GO:0031414 | N-terminal protein acetyltransferase complex(GO:0031414) |
0.0 | 0.4 | GO:0051286 | cell tip(GO:0051286) |
0.0 | 0.5 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
0.0 | 0.5 | GO:0031209 | SCAR complex(GO:0031209) |
0.0 | 1.3 | GO:0097546 | ciliary base(GO:0097546) |
0.0 | 1.0 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) |
0.0 | 0.4 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
0.0 | 0.4 | GO:0031011 | Ino80 complex(GO:0031011) |
0.0 | 0.2 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
0.0 | 0.5 | GO:0033276 | transcription factor TFTC complex(GO:0033276) |
0.0 | 1.7 | GO:0031985 | Golgi cisterna(GO:0031985) |
0.0 | 0.3 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) |
0.0 | 0.5 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
0.0 | 0.2 | GO:0005726 | perichromatin fibrils(GO:0005726) |
0.0 | 2.3 | GO:0030175 | filopodium(GO:0030175) |
0.0 | 461.0 | GO:0005575 | cellular_component(GO:0005575) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.6 | 10.5 | GO:0038049 | glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051) |
2.4 | 7.3 | GO:0030337 | DNA polymerase processivity factor activity(GO:0030337) |
2.1 | 6.2 | GO:0070052 | collagen V binding(GO:0070052) |
1.7 | 6.7 | GO:0004694 | eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694) |
1.2 | 6.1 | GO:0032027 | myosin light chain binding(GO:0032027) |
1.2 | 5.8 | GO:0004032 | alditol:NADP+ 1-oxidoreductase activity(GO:0004032) |
1.1 | 14.7 | GO:0030881 | beta-2-microglobulin binding(GO:0030881) |
1.0 | 1.0 | GO:0003953 | NAD+ nucleosidase activity(GO:0003953) |
1.0 | 3.0 | GO:0030171 | voltage-gated proton channel activity(GO:0030171) |
1.0 | 3.9 | GO:0003844 | 1,4-alpha-glucan branching enzyme activity(GO:0003844) |
0.9 | 3.6 | GO:0047844 | deoxycytidine deaminase activity(GO:0047844) |
0.8 | 3.3 | GO:0046920 | alpha-(1->3)-fucosyltransferase activity(GO:0046920) |
0.8 | 3.2 | GO:0004035 | alkaline phosphatase activity(GO:0004035) |
0.8 | 5.3 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915) |
0.7 | 5.9 | GO:0005138 | interleukin-6 receptor binding(GO:0005138) |
0.7 | 2.2 | GO:0016174 | NAD(P)H oxidase activity(GO:0016174) |
0.7 | 6.1 | GO:0008329 | signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187) |
0.7 | 8.8 | GO:0031386 | protein tag(GO:0031386) |
0.7 | 11.4 | GO:0017166 | vinculin binding(GO:0017166) |
0.7 | 2.0 | GO:0098770 | FBXO family protein binding(GO:0098770) |
0.6 | 3.9 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
0.6 | 2.5 | GO:0008475 | procollagen-lysine 5-dioxygenase activity(GO:0008475) |
0.6 | 3.6 | GO:0033743 | peptide-methionine (R)-S-oxide reductase activity(GO:0033743) |
0.6 | 1.8 | GO:0031798 | type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052) |
0.6 | 11.8 | GO:0045295 | gamma-catenin binding(GO:0045295) |
0.6 | 12.0 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
0.5 | 2.1 | GO:0004999 | vasoactive intestinal polypeptide receptor activity(GO:0004999) |
0.5 | 2.0 | GO:0016647 | oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647) |
0.5 | 2.9 | GO:0046977 | TAP binding(GO:0046977) |
0.5 | 4.3 | GO:0051434 | BH3 domain binding(GO:0051434) |
0.5 | 1.4 | GO:0008176 | tRNA (guanine-N7-)-methyltransferase activity(GO:0008176) |
0.4 | 3.1 | GO:0034513 | box H/ACA snoRNA binding(GO:0034513) |
0.4 | 1.7 | GO:0004466 | long-chain-acyl-CoA dehydrogenase activity(GO:0004466) |
0.4 | 1.2 | GO:0004658 | propionyl-CoA carboxylase activity(GO:0004658) |
0.4 | 1.2 | GO:0005171 | hepatocyte growth factor receptor binding(GO:0005171) |
0.4 | 1.6 | GO:0034618 | arginine binding(GO:0034618) |
0.4 | 1.6 | GO:0035877 | death effector domain binding(GO:0035877) |
0.4 | 4.3 | GO:0003689 | DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) |
0.4 | 4.1 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
0.3 | 4.2 | GO:0031996 | thioesterase binding(GO:0031996) |
0.3 | 1.0 | GO:0004473 | malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473) |
0.3 | 1.9 | GO:0060698 | endoribonuclease inhibitor activity(GO:0060698) |
0.3 | 1.8 | GO:0070644 | vitamin D response element binding(GO:0070644) |
0.3 | 1.5 | GO:0038085 | vascular endothelial growth factor binding(GO:0038085) |
0.3 | 1.4 | GO:0086056 | voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056) |
0.3 | 0.3 | GO:0070815 | peptidyl-lysine 5-dioxygenase activity(GO:0070815) |
0.3 | 8.1 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
0.2 | 4.9 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
0.2 | 0.9 | GO:0045131 | pre-mRNA branch point binding(GO:0045131) |
0.2 | 0.9 | GO:0072345 | NAADP-sensitive calcium-release channel activity(GO:0072345) |
0.2 | 0.7 | GO:0004022 | alcohol dehydrogenase (NAD) activity(GO:0004022) |
0.2 | 6.4 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
0.2 | 4.3 | GO:0001848 | complement binding(GO:0001848) |
0.2 | 0.6 | GO:0005110 | frizzled-2 binding(GO:0005110) |
0.2 | 0.8 | GO:0005008 | hepatocyte growth factor-activated receptor activity(GO:0005008) |
0.2 | 1.5 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
0.2 | 0.7 | GO:0034714 | type III transforming growth factor beta receptor binding(GO:0034714) |
0.2 | 2.0 | GO:0019531 | secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531) |
0.2 | 0.9 | GO:0043891 | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891) |
0.2 | 0.5 | GO:0004637 | phosphoribosylamine-glycine ligase activity(GO:0004637) |
0.2 | 8.1 | GO:0030332 | cyclin binding(GO:0030332) |
0.2 | 1.2 | GO:0031419 | cobalamin binding(GO:0031419) |
0.2 | 0.5 | GO:0034211 | GTP-dependent protein kinase activity(GO:0034211) |
0.2 | 0.8 | GO:0031852 | mu-type opioid receptor binding(GO:0031852) |
0.2 | 4.1 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
0.2 | 2.7 | GO:1904264 | ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264) |
0.2 | 0.8 | GO:0004839 | ubiquitin activating enzyme activity(GO:0004839) |
0.2 | 0.5 | GO:0005030 | neurotrophin receptor activity(GO:0005030) |
0.1 | 3.2 | GO:0070410 | co-SMAD binding(GO:0070410) |
0.1 | 0.5 | GO:0005111 | type 2 fibroblast growth factor receptor binding(GO:0005111) |
0.1 | 10.5 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
0.1 | 3.6 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
0.1 | 3.5 | GO:0070064 | proline-rich region binding(GO:0070064) |
0.1 | 1.0 | GO:0070290 | N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290) |
0.1 | 0.9 | GO:0047429 | nucleoside-triphosphate diphosphatase activity(GO:0047429) |
0.1 | 4.5 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
0.1 | 1.6 | GO:0044548 | S100 protein binding(GO:0044548) |
0.1 | 2.0 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
0.1 | 3.3 | GO:0042805 | actinin binding(GO:0042805) |
0.1 | 0.8 | GO:0048403 | brain-derived neurotrophic factor binding(GO:0048403) |
0.1 | 0.7 | GO:0000403 | Y-form DNA binding(GO:0000403) |
0.1 | 0.6 | GO:1990715 | mRNA CDS binding(GO:1990715) |
0.1 | 0.5 | GO:0031489 | myosin V binding(GO:0031489) |
0.1 | 0.9 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
0.1 | 1.2 | GO:0015271 | outward rectifier potassium channel activity(GO:0015271) |
0.1 | 0.6 | GO:0042296 | ISG15 transferase activity(GO:0042296) |
0.1 | 0.7 | GO:0046703 | natural killer cell lectin-like receptor binding(GO:0046703) |
0.1 | 0.4 | GO:0004582 | dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582) |
0.1 | 0.3 | GO:0008195 | phosphatidate phosphatase activity(GO:0008195) |
0.1 | 0.4 | GO:0034711 | inhibin binding(GO:0034711) |
0.1 | 0.3 | GO:0043559 | insulin binding(GO:0043559) |
0.1 | 5.2 | GO:0016836 | hydro-lyase activity(GO:0016836) |
0.1 | 0.7 | GO:0090599 | alpha-glucosidase activity(GO:0090599) |
0.1 | 0.3 | GO:0046538 | bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538) |
0.1 | 4.1 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
0.1 | 0.5 | GO:0034046 | poly(G) binding(GO:0034046) |
0.1 | 0.7 | GO:0019871 | sodium channel inhibitor activity(GO:0019871) |
0.1 | 0.5 | GO:0015288 | porin activity(GO:0015288) |
0.1 | 1.1 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
0.1 | 0.6 | GO:0036402 | proteasome-activating ATPase activity(GO:0036402) |
0.1 | 1.2 | GO:0008484 | sulfuric ester hydrolase activity(GO:0008484) |
0.1 | 1.2 | GO:0002161 | aminoacyl-tRNA editing activity(GO:0002161) |
0.1 | 0.2 | GO:0004510 | tryptophan 5-monooxygenase activity(GO:0004510) |
0.1 | 1.5 | GO:0071837 | HMG box domain binding(GO:0071837) |
0.1 | 0.3 | GO:0004920 | interleukin-10 receptor activity(GO:0004920) |
0.1 | 2.0 | GO:0070182 | DNA polymerase binding(GO:0070182) |
0.1 | 0.7 | GO:0016634 | oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634) |
0.1 | 6.7 | GO:0046332 | SMAD binding(GO:0046332) |
0.1 | 0.5 | GO:0005372 | water transmembrane transporter activity(GO:0005372) |
0.1 | 3.3 | GO:0015144 | carbohydrate transmembrane transporter activity(GO:0015144) carbohydrate transporter activity(GO:1901476) |
0.1 | 0.4 | GO:0015265 | urea channel activity(GO:0015265) |
0.1 | 1.4 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
0.1 | 1.1 | GO:0005123 | death receptor binding(GO:0005123) |
0.1 | 1.2 | GO:0005328 | neurotransmitter:sodium symporter activity(GO:0005328) |
0.1 | 0.8 | GO:0032813 | tumor necrosis factor receptor superfamily binding(GO:0032813) |
0.1 | 36.5 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
0.1 | 0.9 | GO:0000400 | four-way junction DNA binding(GO:0000400) |
0.1 | 0.4 | GO:0030375 | thyroid hormone receptor coactivator activity(GO:0030375) |
0.1 | 0.4 | GO:1990948 | ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948) |
0.1 | 1.0 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
0.1 | 0.8 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
0.1 | 1.6 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
0.1 | 1.3 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
0.1 | 1.2 | GO:0008266 | poly(U) RNA binding(GO:0008266) |
0.1 | 5.7 | GO:0008083 | growth factor activity(GO:0008083) |
0.1 | 0.2 | GO:0009881 | photoreceptor activity(GO:0009881) |
0.1 | 6.2 | GO:0036459 | thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005) |
0.1 | 3.2 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
0.1 | 3.0 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
0.1 | 2.7 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
0.1 | 1.5 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
0.1 | 3.4 | GO:0046906 | tetrapyrrole binding(GO:0046906) |
0.1 | 1.0 | GO:0017049 | GTP-Rho binding(GO:0017049) |
0.1 | 2.6 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
0.1 | 0.4 | GO:0050681 | androgen receptor binding(GO:0050681) |
0.1 | 0.2 | GO:0005166 | neurotrophin p75 receptor binding(GO:0005166) |
0.0 | 0.4 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
0.0 | 0.3 | GO:0010521 | telomerase inhibitor activity(GO:0010521) |
0.0 | 1.6 | GO:0001671 | ATPase activator activity(GO:0001671) |
0.0 | 0.6 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
0.0 | 12.0 | GO:0003924 | GTPase activity(GO:0003924) |
0.0 | 0.3 | GO:0001609 | G-protein coupled adenosine receptor activity(GO:0001609) |
0.0 | 0.2 | GO:0004126 | cytidine deaminase activity(GO:0004126) |
0.0 | 0.2 | GO:0004661 | protein geranylgeranyltransferase activity(GO:0004661) |
0.0 | 0.3 | GO:0043023 | ribosomal large subunit binding(GO:0043023) |
0.0 | 1.1 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
0.0 | 0.2 | GO:0016531 | copper chaperone activity(GO:0016531) |
0.0 | 0.6 | GO:0009982 | pseudouridine synthase activity(GO:0009982) |
0.0 | 0.6 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
0.0 | 0.1 | GO:0016635 | oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635) |
0.0 | 0.4 | GO:0016624 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624) |
0.0 | 0.3 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
0.0 | 1.5 | GO:0008080 | N-acetyltransferase activity(GO:0008080) |
0.0 | 1.5 | GO:0050840 | extracellular matrix binding(GO:0050840) |
0.0 | 0.4 | GO:0045499 | chemorepellent activity(GO:0045499) |
0.0 | 0.8 | GO:0016891 | endoribonuclease activity, producing 5'-phosphomonoesters(GO:0016891) |
0.0 | 0.3 | GO:0070181 | small ribosomal subunit rRNA binding(GO:0070181) |
0.0 | 0.5 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
0.0 | 0.1 | GO:0036004 | GAF domain binding(GO:0036004) |
0.0 | 3.5 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
0.0 | 0.1 | GO:0033691 | sialic acid binding(GO:0033691) |
0.0 | 0.9 | GO:0051539 | 4 iron, 4 sulfur cluster binding(GO:0051539) |
0.0 | 12.2 | GO:0003712 | transcription cofactor activity(GO:0003712) |
0.0 | 0.3 | GO:0004679 | AMP-activated protein kinase activity(GO:0004679) |
0.0 | 10.3 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
0.0 | 0.6 | GO:0030515 | snoRNA binding(GO:0030515) |
0.0 | 0.6 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
0.0 | 1.2 | GO:0005484 | SNAP receptor activity(GO:0005484) |
0.0 | 0.1 | GO:0047192 | 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192) |
0.0 | 1.3 | GO:0019955 | cytokine binding(GO:0019955) |
0.0 | 1.1 | GO:0030594 | neurotransmitter receptor activity(GO:0030594) |
0.0 | 0.8 | GO:0008028 | monocarboxylic acid transmembrane transporter activity(GO:0008028) |
0.0 | 0.5 | GO:0005242 | inward rectifier potassium channel activity(GO:0005242) |
0.0 | 0.4 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
0.0 | 2.5 | GO:0030165 | PDZ domain binding(GO:0030165) |
0.0 | 0.4 | GO:0004623 | phospholipase A2 activity(GO:0004623) |
0.0 | 0.5 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
0.0 | 303.1 | GO:0003674 | molecular_function(GO:0003674) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 27.3 | PID_IL12_2PATHWAY | IL12-mediated signaling events |
0.4 | 3.2 | ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY | PI3K Pathway |
0.3 | 12.8 | PID_BARD1_PATHWAY | BARD1 signaling events |
0.3 | 22.2 | PID_AP1_PATHWAY | AP-1 transcription factor network |
0.3 | 2.6 | PID_IL12_STAT4_PATHWAY | IL12 signaling mediated by STAT4 |
0.3 | 14.9 | PID_TCPTP_PATHWAY | Signaling events mediated by TCPTP |
0.2 | 2.1 | SA_FAS_SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
0.2 | 6.4 | PID_FANCONI_PATHWAY | Fanconi anemia pathway |
0.2 | 25.1 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
0.1 | 4.0 | PID_SYNDECAN_4_PATHWAY | Syndecan-4-mediated signaling events |
0.1 | 8.4 | PID_PLK1_PATHWAY | PLK1 signaling events |
0.1 | 2.9 | PID_FOXM1_PATHWAY | FOXM1 transcription factor network |
0.1 | 2.2 | PID_SYNDECAN_2_PATHWAY | Syndecan-2-mediated signaling events |
0.1 | 4.6 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
0.1 | 2.4 | PID_PI3KCI_AKT_PATHWAY | Class I PI3K signaling events mediated by Akt |
0.1 | 2.0 | PID_IL2_STAT5_PATHWAY | IL2 signaling events mediated by STAT5 |
0.1 | 4.5 | NABA_COLLAGENS | Genes encoding collagen proteins |
0.1 | 1.4 | PID_TRAIL_PATHWAY | TRAIL signaling pathway |
0.1 | 1.9 | PID_AMB2_NEUTROPHILS_PATHWAY | amb2 Integrin signaling |
0.1 | 1.9 | PID_P38_ALPHA_BETA_PATHWAY | Regulation of p38-alpha and p38-beta |
0.1 | 6.4 | SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
0.1 | 2.7 | NABA_CORE_MATRISOME | Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans |
0.1 | 1.8 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
0.1 | 2.6 | PID_FCER1_PATHWAY | Fc-epsilon receptor I signaling in mast cells |
0.1 | 1.3 | PID_MYC_PATHWAY | C-MYC pathway |
0.1 | 1.0 | PID_IL8_CXCR1_PATHWAY | IL8- and CXCR1-mediated signaling events |
0.1 | 3.7 | PID_HEDGEHOG_GLI_PATHWAY | Hedgehog signaling events mediated by Gli proteins |
0.1 | 1.6 | SIG_CD40PATHWAYMAP | Genes related to CD40 signaling |
0.1 | 3.3 | PID_LYSOPHOSPHOLIPID_PATHWAY | LPA receptor mediated events |
0.1 | 0.7 | PID_INTEGRIN3_PATHWAY | Beta3 integrin cell surface interactions |
0.1 | 0.6 | PID_IL1_PATHWAY | IL1-mediated signaling events |
0.1 | 0.8 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
0.1 | 4.5 | WNT_SIGNALING | Genes related to Wnt-mediated signal transduction |
0.1 | 1.8 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
0.0 | 1.2 | PID_NFAT_TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
0.0 | 2.3 | PID_BMP_PATHWAY | BMP receptor signaling |
0.0 | 0.9 | PID_RHOA_PATHWAY | RhoA signaling pathway |
0.0 | 1.0 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
0.0 | 2.1 | PID_E2F_PATHWAY | E2F transcription factor network |
0.0 | 2.5 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
0.0 | 4.8 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
0.0 | 0.3 | PID_IL3_PATHWAY | IL3-mediated signaling events |
0.0 | 0.7 | PID_AURORA_B_PATHWAY | Aurora B signaling |
0.0 | 0.6 | PID_RB_1PATHWAY | Regulation of retinoblastoma protein |
0.0 | 0.9 | PID_P73PATHWAY | p73 transcription factor network |
0.0 | 0.1 | PID_TCR_JNK_PATHWAY | JNK signaling in the CD4+ TCR pathway |
0.0 | 0.5 | ST_FAS_SIGNALING_PATHWAY | Fas Signaling Pathway |
0.0 | 0.7 | PID_ECADHERIN_STABILIZATION_PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
0.0 | 0.5 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
0.0 | 0.1 | ST_PAC1_RECEPTOR_PATHWAY | PAC1 Receptor Pathway |
0.0 | 0.8 | PID_MYC_ACTIV_PATHWAY | Validated targets of C-MYC transcriptional activation |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
4.1 | 12.3 | REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
1.1 | 17.0 | REACTOME_NFKB_ACTIVATION_THROUGH_FADD_RIP1_PATHWAY_MEDIATED_BY_CASPASE_8_AND10 | Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 |
1.0 | 12.9 | REACTOME_POL_SWITCHING | Genes involved in Polymerase switching |
0.7 | 9.2 | REACTOME_REGULATION_OF_IFNA_SIGNALING | Genes involved in Regulation of IFNA signaling |
0.5 | 1.9 | REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |
0.3 | 3.4 | REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING | Genes involved in Role of second messengers in netrin-1 signaling |
0.3 | 9.2 | REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
0.3 | 9.1 | REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
0.3 | 11.3 | REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
0.3 | 2.4 | REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
0.2 | 2.2 | REACTOME_TRYPTOPHAN_CATABOLISM | Genes involved in Tryptophan catabolism |
0.2 | 5.7 | REACTOME_STRIATED_MUSCLE_CONTRACTION | Genes involved in Striated Muscle Contraction |
0.2 | 3.8 | REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
0.2 | 3.4 | REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
0.2 | 1.3 | REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
0.2 | 4.9 | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
0.2 | 1.3 | REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY | Genes involved in Regulation of the Fanconi anemia pathway |
0.2 | 3.1 | REACTOME_EXTENSION_OF_TELOMERES | Genes involved in Extension of Telomeres |
0.2 | 1.8 | REACTOME_KERATAN_SULFATE_DEGRADATION | Genes involved in Keratan sulfate degradation |
0.2 | 2.9 | REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
0.2 | 0.9 | REACTOME_INFLAMMASOMES | Genes involved in Inflammasomes |
0.2 | 2.1 | REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS | Genes involved in Glucagon-type ligand receptors |
0.2 | 4.0 | REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
0.2 | 1.2 | REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
0.1 | 2.4 | REACTOME_DNA_STRAND_ELONGATION | Genes involved in DNA strand elongation |
0.1 | 1.4 | REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
0.1 | 2.7 | REACTOME_HS_GAG_DEGRADATION | Genes involved in HS-GAG degradation |
0.1 | 1.6 | REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION | Genes involved in TRAF6 mediated NF-kB activation |
0.1 | 1.2 | REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
0.1 | 4.2 | REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
0.1 | 7.0 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
0.1 | 1.2 | REACTOME_AMINE_DERIVED_HORMONES | Genes involved in Amine-derived hormones |
0.1 | 1.0 | REACTOME_CALNEXIN_CALRETICULIN_CYCLE | Genes involved in Calnexin/calreticulin cycle |
0.1 | 4.1 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
0.1 | 6.5 | REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
0.1 | 1.7 | REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
0.1 | 1.8 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
0.1 | 0.9 | REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
0.1 | 4.2 | REACTOME_AMYLOIDS | Genes involved in Amyloids |
0.1 | 1.3 | REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS | Genes involved in Activation of ATR in response to replication stress |
0.1 | 0.8 | REACTOME_FANCONI_ANEMIA_PATHWAY | Genes involved in Fanconi Anemia pathway |
0.1 | 1.1 | REACTOME_METABOLISM_OF_STEROID_HORMONES_AND_VITAMINS_A_AND_D | Genes involved in Metabolism of steroid hormones and vitamins A and D |
0.1 | 0.1 | REACTOME_THROMBOXANE_SIGNALLING_THROUGH_TP_RECEPTOR | Genes involved in Thromboxane signalling through TP receptor |
0.1 | 1.6 | REACTOME_GLUTATHIONE_CONJUGATION | Genes involved in Glutathione conjugation |
0.1 | 0.6 | REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS | Genes involved in Amine compound SLC transporters |
0.1 | 0.5 | REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
0.1 | 0.4 | REACTOME_AQUAPORIN_MEDIATED_TRANSPORT | Genes involved in Aquaporin-mediated transport |
0.1 | 1.3 | REACTOME_SIGNALING_BY_BMP | Genes involved in Signaling by BMP |
0.1 | 0.9 | REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
0.1 | 0.4 | REACTOME_ACYL_CHAIN_REMODELLING_OF_PI | Genes involved in Acyl chain remodelling of PI |
0.0 | 1.6 | REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT | Genes involved in Regulation of beta-cell development |
0.0 | 1.1 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
0.0 | 0.6 | REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
0.0 | 2.3 | REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S | Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
0.0 | 0.8 | REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
0.0 | 0.5 | REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
0.0 | 2.8 | REACTOME_GLUCOSE_METABOLISM | Genes involved in Glucose metabolism |
0.0 | 2.3 | REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION | Genes involved in 3' -UTR-mediated translational regulation |
0.0 | 3.2 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
0.0 | 7.2 | REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
0.0 | 0.7 | REACTOME_METABOLISM_OF_PORPHYRINS | Genes involved in Metabolism of porphyrins |
0.0 | 1.3 | REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
0.0 | 0.6 | REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
0.0 | 0.8 | REACTOME_PIP3_ACTIVATES_AKT_SIGNALING | Genes involved in PIP3 activates AKT signaling |
0.0 | 0.3 | REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
0.0 | 0.3 | REACTOME_SYNTHESIS_OF_PE | Genes involved in Synthesis of PE |
0.0 | 1.0 | REACTOME_NETRIN1_SIGNALING | Genes involved in Netrin-1 signaling |
0.0 | 0.2 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
0.0 | 0.2 | REACTOME_ERKS_ARE_INACTIVATED | Genes involved in ERKs are inactivated |
0.0 | 0.2 | REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
0.0 | 0.5 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
0.0 | 0.4 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
0.0 | 0.4 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
0.0 | 0.2 | REACTOME_INTERFERON_GAMMA_SIGNALING | Genes involved in Interferon gamma signaling |
0.0 | 1.8 | REACTOME_MRNA_SPLICING | Genes involved in mRNA Splicing |
0.0 | 0.5 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
0.0 | 1.0 | REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION | Genes involved in PPARA Activates Gene Expression |
0.0 | 0.3 | REACTOME_IL_RECEPTOR_SHC_SIGNALING | Genes involved in Interleukin receptor SHC signaling |
0.0 | 0.1 | REACTOME_ACYL_CHAIN_REMODELLING_OF_PG | Genes involved in Acyl chain remodelling of PG |
0.0 | 0.5 | REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |