Motif ID: Irx6_Irx2_Irx3
Z-value: 0.825



Transcription factors associated with Irx6_Irx2_Irx3:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Irx2 | ENSMUSG00000001504.9 | Irx2 |
Irx3 | ENSMUSG00000031734.11 | Irx3 |
Irx6 | ENSMUSG00000031738.8 | Irx6 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Irx2 | mm10_v2_chr13_+_72628831_72628971 | -0.16 | 3.1e-01 | Click! |
Irx3 | mm10_v2_chr8_-_91801948_91802067 | 0.12 | 4.7e-01 | Click! |
Irx6 | mm10_v2_chr8_+_92674826_92674826 | 0.04 | 7.8e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.6 | 7.8 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
0.3 | 1.0 | GO:2000659 | regulation of interleukin-1-mediated signaling pathway(GO:2000659) |
0.3 | 0.9 | GO:1900041 | negative regulation of interleukin-2 secretion(GO:1900041) |
0.3 | 0.8 | GO:0060785 | regulation of apoptosis involved in tissue homeostasis(GO:0060785) |
0.2 | 0.7 | GO:0060129 | BMP signaling pathway involved in heart induction(GO:0003130) endodermal-mesodermal cell signaling(GO:0003133) endodermal-mesodermal cell signaling involved in heart induction(GO:0003134) thyroid-stimulating hormone-secreting cell differentiation(GO:0060129) |
0.2 | 1.0 | GO:0032382 | positive regulation of intracellular lipid transport(GO:0032379) positive regulation of intracellular sterol transport(GO:0032382) positive regulation of intracellular cholesterol transport(GO:0032385) lipid hydroperoxide transport(GO:1901373) |
0.2 | 2.4 | GO:0019243 | methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727) |
0.2 | 0.7 | GO:0048687 | positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) |
0.2 | 0.9 | GO:1901164 | negative regulation of trophoblast cell migration(GO:1901164) |
0.1 | 0.4 | GO:0043379 | memory T cell differentiation(GO:0043379) |
0.1 | 2.5 | GO:0007130 | synaptonemal complex assembly(GO:0007130) |
0.1 | 0.4 | GO:0006030 | chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032) |
0.1 | 0.4 | GO:0070103 | regulation of interleukin-6-mediated signaling pathway(GO:0070103) negative regulation of interleukin-6-mediated signaling pathway(GO:0070104) |
0.1 | 0.7 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
0.1 | 2.0 | GO:0019369 | arachidonic acid metabolic process(GO:0019369) |
0.1 | 0.6 | GO:0042891 | antibiotic transport(GO:0042891) dipeptide transport(GO:0042938) |
0.1 | 0.3 | GO:2001180 | negative regulation of interleukin-18 production(GO:0032701) negative regulation of interleukin-10 secretion(GO:2001180) |
0.1 | 0.3 | GO:0070543 | response to linoleic acid(GO:0070543) |
0.1 | 0.6 | GO:0009235 | cobalamin metabolic process(GO:0009235) |
0.1 | 0.3 | GO:0072488 | ammonium transmembrane transport(GO:0072488) |
0.1 | 0.5 | GO:0072008 | glomerular mesangial cell differentiation(GO:0072008) glomerular mesangial cell development(GO:0072144) |
0.1 | 1.9 | GO:0045947 | negative regulation of translational initiation(GO:0045947) |
0.1 | 0.8 | GO:0030035 | microspike assembly(GO:0030035) |
0.1 | 0.9 | GO:0046085 | adenosine metabolic process(GO:0046085) |
0.1 | 0.3 | GO:0051771 | negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771) |
0.1 | 0.3 | GO:0006420 | arginyl-tRNA aminoacylation(GO:0006420) |
0.1 | 0.3 | GO:0006982 | response to lipid hydroperoxide(GO:0006982) cellular response to lipid hydroperoxide(GO:0071449) |
0.1 | 0.2 | GO:0006106 | fumarate metabolic process(GO:0006106) |
0.1 | 0.7 | GO:0009162 | deoxyribonucleoside monophosphate metabolic process(GO:0009162) |
0.1 | 0.2 | GO:0009794 | regulation of mitotic cell cycle, embryonic(GO:0009794) mitotic cell cycle, embryonic(GO:0045448) |
0.1 | 1.3 | GO:0006465 | signal peptide processing(GO:0006465) |
0.1 | 0.4 | GO:0042276 | error-prone translesion synthesis(GO:0042276) |
0.1 | 0.3 | GO:0042138 | meiotic DNA double-strand break formation(GO:0042138) |
0.1 | 0.2 | GO:0006507 | GPI anchor release(GO:0006507) |
0.1 | 0.2 | GO:0051030 | snRNA transport(GO:0051030) |
0.1 | 0.2 | GO:0010700 | negative regulation of norepinephrine secretion(GO:0010700) microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139) |
0.1 | 0.7 | GO:0090073 | positive regulation of protein homodimerization activity(GO:0090073) |
0.1 | 0.4 | GO:0006390 | transcription from mitochondrial promoter(GO:0006390) |
0.1 | 0.7 | GO:0034551 | respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033) |
0.1 | 0.5 | GO:0042435 | indole-containing compound biosynthetic process(GO:0042435) |
0.1 | 0.2 | GO:0030043 | actin filament fragmentation(GO:0030043) |
0.1 | 0.3 | GO:0035745 | T-helper 2 cell cytokine production(GO:0035745) |
0.1 | 0.4 | GO:0045743 | positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743) |
0.1 | 0.6 | GO:1901409 | positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
0.1 | 0.5 | GO:0006071 | glycerol metabolic process(GO:0006071) |
0.1 | 0.8 | GO:0009048 | dosage compensation by inactivation of X chromosome(GO:0009048) |
0.1 | 0.4 | GO:0006620 | posttranslational protein targeting to membrane(GO:0006620) |
0.0 | 1.1 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
0.0 | 0.1 | GO:0014809 | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809) |
0.0 | 0.3 | GO:0010624 | regulation of Schwann cell proliferation(GO:0010624) |
0.0 | 0.3 | GO:0015014 | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014) |
0.0 | 0.9 | GO:1901629 | regulation of presynaptic membrane organization(GO:1901629) |
0.0 | 0.1 | GO:0002904 | positive regulation of B cell apoptotic process(GO:0002904) |
0.0 | 0.9 | GO:0051482 | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482) |
0.0 | 0.3 | GO:0006616 | SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616) |
0.0 | 0.6 | GO:0006388 | tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388) |
0.0 | 0.2 | GO:0050651 | dermatan sulfate proteoglycan biosynthetic process(GO:0050651) |
0.0 | 0.2 | GO:0070171 | negative regulation of tooth mineralization(GO:0070171) |
0.0 | 0.3 | GO:0035726 | common myeloid progenitor cell proliferation(GO:0035726) |
0.0 | 0.4 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
0.0 | 0.2 | GO:1900272 | negative regulation of long-term synaptic potentiation(GO:1900272) |
0.0 | 0.2 | GO:0018344 | protein geranylgeranylation(GO:0018344) |
0.0 | 0.2 | GO:0071955 | recycling endosome to Golgi transport(GO:0071955) |
0.0 | 0.3 | GO:0006560 | proline metabolic process(GO:0006560) |
0.0 | 0.3 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
0.0 | 0.6 | GO:0046321 | positive regulation of fatty acid oxidation(GO:0046321) |
0.0 | 0.5 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
0.0 | 0.3 | GO:0006228 | UTP biosynthetic process(GO:0006228) |
0.0 | 0.4 | GO:0006488 | dolichol-linked oligosaccharide biosynthetic process(GO:0006488) |
0.0 | 1.3 | GO:0021591 | ventricular system development(GO:0021591) |
0.0 | 0.2 | GO:0048254 | snoRNA localization(GO:0048254) |
0.0 | 0.9 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
0.0 | 0.2 | GO:0097343 | ripoptosome assembly(GO:0097343) ripoptosome assembly involved in necroptotic process(GO:1901026) |
0.0 | 0.2 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
0.0 | 0.4 | GO:0006517 | protein deglycosylation(GO:0006517) |
0.0 | 0.2 | GO:0002606 | positive regulation of dendritic cell antigen processing and presentation(GO:0002606) detection of bacterium(GO:0016045) detection of other organism(GO:0098543) |
0.0 | 0.1 | GO:1900533 | medium-chain fatty-acyl-CoA catabolic process(GO:0036114) fatty-acyl-CoA catabolic process(GO:0036115) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535) |
0.0 | 0.2 | GO:0002377 | immunoglobulin production(GO:0002377) |
0.0 | 0.4 | GO:0006309 | apoptotic DNA fragmentation(GO:0006309) |
0.0 | 0.2 | GO:0006682 | galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375) |
0.0 | 0.1 | GO:0019389 | glucuronoside metabolic process(GO:0019389) |
0.0 | 0.3 | GO:0032611 | interleukin-1 beta production(GO:0032611) |
0.0 | 0.1 | GO:1904352 | positive regulation of protein catabolic process in the vacuole(GO:1904352) |
0.0 | 0.2 | GO:0000972 | transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972) |
0.0 | 0.0 | GO:0002578 | negative regulation of antigen processing and presentation(GO:0002578) |
0.0 | 0.1 | GO:0042636 | negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279) |
0.0 | 0.1 | GO:1903847 | regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849) |
0.0 | 0.2 | GO:0018065 | protein-cofactor linkage(GO:0018065) |
0.0 | 0.1 | GO:0071211 | protein targeting to vacuole involved in autophagy(GO:0071211) |
0.0 | 0.8 | GO:0035456 | response to interferon-beta(GO:0035456) |
0.0 | 2.4 | GO:0048515 | spermatid differentiation(GO:0048515) |
0.0 | 0.1 | GO:0045650 | negative regulation of macrophage differentiation(GO:0045650) |
0.0 | 0.2 | GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977) |
0.0 | 0.3 | GO:0097034 | mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034) |
0.0 | 0.5 | GO:1902857 | positive regulation of nonmotile primary cilium assembly(GO:1902857) |
0.0 | 0.1 | GO:0006624 | vacuolar protein processing(GO:0006624) |
0.0 | 0.1 | GO:0043983 | histone H4-K12 acetylation(GO:0043983) |
0.0 | 0.1 | GO:0090666 | scaRNA localization to Cajal body(GO:0090666) |
0.0 | 2.1 | GO:0006334 | nucleosome assembly(GO:0006334) |
0.0 | 0.7 | GO:0000462 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462) |
0.0 | 0.1 | GO:0032687 | negative regulation of interferon-alpha production(GO:0032687) |
0.0 | 1.0 | GO:0045773 | positive regulation of axon extension(GO:0045773) |
0.0 | 0.2 | GO:0033683 | nucleotide-excision repair, DNA incision(GO:0033683) |
0.0 | 0.5 | GO:0050853 | B cell receptor signaling pathway(GO:0050853) |
0.0 | 1.8 | GO:0010811 | positive regulation of cell-substrate adhesion(GO:0010811) |
0.0 | 0.2 | GO:0070234 | positive regulation of T cell apoptotic process(GO:0070234) |
0.0 | 0.1 | GO:1904153 | negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153) |
0.0 | 0.2 | GO:0035455 | response to interferon-alpha(GO:0035455) |
0.0 | 0.4 | GO:0032011 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
0.0 | 0.7 | GO:0022904 | respiratory electron transport chain(GO:0022904) |
0.0 | 0.3 | GO:0018126 | protein hydroxylation(GO:0018126) |
0.0 | 0.1 | GO:0008611 | ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503) |
0.0 | 0.1 | GO:0006177 | GMP biosynthetic process(GO:0006177) |
0.0 | 0.2 | GO:0032088 | negative regulation of NF-kappaB transcription factor activity(GO:0032088) |
0.0 | 0.2 | GO:0016226 | iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163) |
0.0 | 0.0 | GO:0046022 | regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022) |
0.0 | 0.6 | GO:0045454 | cell redox homeostasis(GO:0045454) |
0.0 | 0.1 | GO:0090110 | cargo loading into COPII-coated vesicle(GO:0090110) |
0.0 | 0.1 | GO:0047484 | regulation of response to osmotic stress(GO:0047484) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.8 | 2.5 | GO:0000801 | central element(GO:0000801) |
0.7 | 7.8 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
0.2 | 0.7 | GO:0097058 | CRLF-CLCF1 complex(GO:0097058) |
0.2 | 0.8 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
0.2 | 1.3 | GO:0005787 | signal peptidase complex(GO:0005787) |
0.1 | 0.7 | GO:0042719 | mitochondrial intermembrane space protein transporter complex(GO:0042719) |
0.1 | 1.0 | GO:0031315 | extrinsic component of mitochondrial outer membrane(GO:0031315) |
0.1 | 1.8 | GO:0005614 | interstitial matrix(GO:0005614) |
0.1 | 0.7 | GO:0005964 | phosphorylase kinase complex(GO:0005964) |
0.1 | 1.2 | GO:0005687 | U4 snRNP(GO:0005687) |
0.1 | 0.3 | GO:0005965 | protein farnesyltransferase complex(GO:0005965) |
0.1 | 0.3 | GO:0070985 | TFIIK complex(GO:0070985) |
0.1 | 0.3 | GO:0097450 | astrocyte end-foot(GO:0097450) |
0.1 | 0.6 | GO:0030915 | Smc5-Smc6 complex(GO:0030915) |
0.1 | 0.8 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
0.1 | 0.2 | GO:0097233 | lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233) |
0.1 | 0.7 | GO:0061574 | ASAP complex(GO:0061574) |
0.1 | 0.4 | GO:0016035 | zeta DNA polymerase complex(GO:0016035) |
0.1 | 0.3 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
0.1 | 0.9 | GO:0046930 | pore complex(GO:0046930) |
0.1 | 0.9 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
0.1 | 0.6 | GO:0072669 | tRNA-splicing ligase complex(GO:0072669) |
0.1 | 0.3 | GO:0097361 | CIA complex(GO:0097361) |
0.1 | 0.3 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
0.0 | 0.4 | GO:0001520 | outer dense fiber(GO:0001520) |
0.0 | 0.2 | GO:0031021 | interphase microtubule organizing center(GO:0031021) |
0.0 | 0.2 | GO:0005968 | Rab-protein geranylgeranyltransferase complex(GO:0005968) |
0.0 | 0.1 | GO:0033186 | CAF-1 complex(GO:0033186) |
0.0 | 0.3 | GO:0070847 | core mediator complex(GO:0070847) |
0.0 | 0.9 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
0.0 | 0.1 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
0.0 | 0.4 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) |
0.0 | 0.4 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
0.0 | 0.9 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
0.0 | 0.1 | GO:0043512 | inhibin A complex(GO:0043512) |
0.0 | 0.5 | GO:0031464 | Cul4A-RING E3 ubiquitin ligase complex(GO:0031464) |
0.0 | 1.6 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
0.0 | 0.2 | GO:0031428 | box C/D snoRNP complex(GO:0031428) |
0.0 | 1.8 | GO:0000786 | nucleosome(GO:0000786) |
0.0 | 1.1 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
0.0 | 0.4 | GO:0002080 | acrosomal membrane(GO:0002080) |
0.0 | 1.5 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
0.0 | 0.1 | GO:0031088 | platelet dense granule membrane(GO:0031088) intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637) |
0.0 | 0.1 | GO:0097422 | tubular endosome(GO:0097422) |
0.0 | 0.2 | GO:0072546 | ER membrane protein complex(GO:0072546) |
0.0 | 6.4 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
0.0 | 0.9 | GO:0005581 | collagen trimer(GO:0005581) |
0.0 | 0.1 | GO:0042613 | MHC class II protein complex(GO:0042613) |
0.0 | 0.1 | GO:0000836 | ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836) |
0.0 | 0.2 | GO:0097542 | ciliary tip(GO:0097542) |
0.0 | 1.7 | GO:0031227 | intrinsic component of endoplasmic reticulum membrane(GO:0031227) |
0.0 | 0.3 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
0.0 | 0.2 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
0.0 | 0.2 | GO:0045239 | tricarboxylic acid cycle enzyme complex(GO:0045239) |
0.0 | 0.2 | GO:0031083 | BLOC-1 complex(GO:0031083) |
0.0 | 0.1 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.7 | 2.0 | GO:0008392 | arachidonic acid epoxygenase activity(GO:0008392) |
0.6 | 1.8 | GO:0070052 | collagen V binding(GO:0070052) |
0.5 | 7.1 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
0.3 | 2.4 | GO:0004416 | hydroxyacylglutathione hydrolase activity(GO:0004416) |
0.3 | 0.8 | GO:0072541 | peroxynitrite reductase activity(GO:0072541) |
0.2 | 1.0 | GO:0050632 | propanoyl-CoA C-acyltransferase activity(GO:0033814) propionyl-CoA C2-trimethyltridecanoyltransferase activity(GO:0050632) phosphatidylethanolamine transporter activity(GO:1904121) |
0.2 | 0.8 | GO:0031720 | haptoglobin binding(GO:0031720) |
0.2 | 0.6 | GO:0042936 | dipeptide transporter activity(GO:0042936) |
0.2 | 1.9 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
0.2 | 0.8 | GO:0047134 | protein-disulfide reductase activity(GO:0047134) |
0.1 | 0.4 | GO:0051870 | methotrexate binding(GO:0051870) |
0.1 | 3.0 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
0.1 | 0.4 | GO:0004568 | chitinase activity(GO:0004568) |
0.1 | 0.4 | GO:0016160 | alpha-amylase activity(GO:0004556) amylase activity(GO:0016160) |
0.1 | 0.4 | GO:0097677 | STAT family protein binding(GO:0097677) |
0.1 | 0.9 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915) |
0.1 | 0.9 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
0.1 | 0.8 | GO:0043199 | sulfate binding(GO:0043199) |
0.1 | 0.4 | GO:0004531 | deoxyribonuclease II activity(GO:0004531) |
0.1 | 0.4 | GO:0004510 | tryptophan 5-monooxygenase activity(GO:0004510) |
0.1 | 0.3 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
0.1 | 0.7 | GO:0019211 | phosphatase activator activity(GO:0019211) |
0.1 | 0.6 | GO:1990932 | 5.8S rRNA binding(GO:1990932) |
0.1 | 0.7 | GO:0004689 | phosphorylase kinase activity(GO:0004689) |
0.1 | 0.8 | GO:0005138 | interleukin-6 receptor binding(GO:0005138) |
0.1 | 0.3 | GO:0004660 | protein farnesyltransferase activity(GO:0004660) |
0.1 | 0.3 | GO:0004492 | methylmalonyl-CoA decarboxylase activity(GO:0004492) |
0.1 | 0.3 | GO:0004814 | arginine-tRNA ligase activity(GO:0004814) |
0.1 | 1.3 | GO:0015269 | calcium-activated potassium channel activity(GO:0015269) |
0.1 | 0.3 | GO:0000179 | rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) |
0.1 | 0.3 | GO:0042328 | heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328) |
0.1 | 0.4 | GO:0004984 | olfactory receptor activity(GO:0004984) |
0.1 | 0.9 | GO:0008097 | 5S rRNA binding(GO:0008097) |
0.1 | 0.2 | GO:0047275 | glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275) |
0.1 | 0.4 | GO:0019841 | retinol binding(GO:0019841) |
0.1 | 0.2 | GO:0004769 | steroid delta-isomerase activity(GO:0004769) |
0.1 | 0.9 | GO:0008253 | 5'-nucleotidase activity(GO:0008253) |
0.1 | 1.1 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
0.1 | 0.2 | GO:0008534 | oxidized purine nucleobase lesion DNA N-glycosylase activity(GO:0008534) |
0.1 | 0.8 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
0.1 | 0.2 | GO:0047237 | glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047237) |
0.1 | 0.5 | GO:1990446 | U1 snRNP binding(GO:1990446) |
0.0 | 0.3 | GO:0008479 | queuine tRNA-ribosyltransferase activity(GO:0008479) |
0.0 | 0.4 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
0.0 | 0.5 | GO:0004659 | prenyltransferase activity(GO:0004659) |
0.0 | 1.8 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
0.0 | 0.7 | GO:0016799 | hydrolase activity, hydrolyzing N-glycosyl compounds(GO:0016799) |
0.0 | 0.3 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
0.0 | 0.2 | GO:0019960 | C-X3-C chemokine binding(GO:0019960) |
0.0 | 0.2 | GO:0050700 | CARD domain binding(GO:0050700) |
0.0 | 0.1 | GO:0033883 | pyridoxal phosphatase activity(GO:0033883) |
0.0 | 0.7 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
0.0 | 0.3 | GO:0015114 | phosphate ion transmembrane transporter activity(GO:0015114) |
0.0 | 0.4 | GO:0001848 | complement binding(GO:0001848) |
0.0 | 0.2 | GO:0043176 | amine binding(GO:0043176) |
0.0 | 0.2 | GO:0001094 | TFIID-class transcription factor binding(GO:0001094) |
0.0 | 0.2 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
0.0 | 0.2 | GO:0015643 | toxic substance binding(GO:0015643) |
0.0 | 0.3 | GO:0022842 | leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842) |
0.0 | 0.3 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
0.0 | 0.2 | GO:0070513 | death domain binding(GO:0070513) |
0.0 | 0.1 | GO:0034452 | dynactin binding(GO:0034452) |
0.0 | 0.1 | GO:0070699 | type II activin receptor binding(GO:0070699) |
0.0 | 1.3 | GO:0043022 | ribosome binding(GO:0043022) |
0.0 | 0.1 | GO:0042030 | ATPase inhibitor activity(GO:0042030) |
0.0 | 0.4 | GO:0017134 | fibroblast growth factor binding(GO:0017134) |
0.0 | 0.3 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
0.0 | 0.1 | GO:0036042 | long-chain fatty acyl-CoA binding(GO:0036042) |
0.0 | 0.5 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
0.0 | 0.3 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
0.0 | 2.5 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
0.0 | 0.8 | GO:0003743 | translation initiation factor activity(GO:0003743) |
0.0 | 0.9 | GO:0015078 | hydrogen ion transmembrane transporter activity(GO:0015078) |
0.0 | 0.0 | GO:0015140 | malate transmembrane transporter activity(GO:0015140) |
0.0 | 0.3 | GO:0071949 | FAD binding(GO:0071949) |
0.0 | 0.5 | GO:0050699 | WW domain binding(GO:0050699) |
0.0 | 0.3 | GO:1900750 | glutathione peroxidase activity(GO:0004602) glutathione binding(GO:0043295) oligopeptide binding(GO:1900750) |
0.0 | 0.2 | GO:0023026 | MHC class II protein complex binding(GO:0023026) |
0.0 | 0.4 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
0.0 | 0.6 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
0.0 | 0.1 | GO:0000268 | peroxisome targeting sequence binding(GO:0000268) |
0.0 | 0.1 | GO:0004745 | retinol dehydrogenase activity(GO:0004745) |
0.0 | 0.2 | GO:0035497 | cAMP response element binding(GO:0035497) |
0.0 | 0.3 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
0.0 | 0.0 | GO:1903135 | cupric ion binding(GO:1903135) |
0.0 | 0.5 | GO:0042169 | SH2 domain binding(GO:0042169) |
0.0 | 0.1 | GO:0008301 | DNA binding, bending(GO:0008301) |
0.0 | 0.0 | GO:0004301 | epoxide hydrolase activity(GO:0004301) |
0.0 | 0.2 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 7.8 | NABA_COLLAGENS | Genes encoding collagen proteins |
0.1 | 0.9 | PID_LPA4_PATHWAY | LPA4-mediated signaling events |
0.0 | 2.4 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
0.0 | 1.1 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
0.0 | 0.7 | PID_BMP_PATHWAY | BMP receptor signaling |
0.0 | 0.2 | PID_INTEGRIN2_PATHWAY | Beta2 integrin cell surface interactions |
0.0 | 0.2 | PID_NFKAPPAB_CANONICAL_PATHWAY | Canonical NF-kappaB pathway |
0.0 | 0.8 | PID_HEDGEHOG_GLI_PATHWAY | Hedgehog signaling events mediated by Gli proteins |
0.0 | 0.1 | ST_STAT3_PATHWAY | STAT3 Pathway |
0.0 | 0.3 | PID_TRAIL_PATHWAY | TRAIL signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 7.9 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
0.1 | 1.2 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
0.1 | 1.7 | REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
0.1 | 0.9 | REACTOME_PYRIMIDINE_CATABOLISM | Genes involved in Pyrimidine catabolism |
0.1 | 1.3 | REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
0.1 | 0.4 | REACTOME_REGULATION_OF_COMPLEMENT_CASCADE | Genes involved in Regulation of Complement cascade |
0.1 | 1.0 | REACTOME_BILE_ACID_AND_BILE_SALT_METABOLISM | Genes involved in Bile acid and bile salt metabolism |
0.0 | 1.1 | REACTOME_OTHER_SEMAPHORIN_INTERACTIONS | Genes involved in Other semaphorin interactions |
0.0 | 1.0 | REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
0.0 | 0.2 | REACTOME_COMMON_PATHWAY | Genes involved in Common Pathway |
0.0 | 0.3 | REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
0.0 | 0.5 | REACTOME_AMINE_DERIVED_HORMONES | Genes involved in Amine-derived hormones |
0.0 | 2.7 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT | Genes involved in Respiratory electron transport |
0.0 | 2.0 | REACTOME_RNA_POL_I_PROMOTER_OPENING | Genes involved in RNA Polymerase I Promoter Opening |
0.0 | 0.5 | REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
0.0 | 0.7 | REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
0.0 | 0.4 | REACTOME_REGULATION_OF_IFNG_SIGNALING | Genes involved in Regulation of IFNG signaling |
0.0 | 0.1 | REACTOME_GLYCOPROTEIN_HORMONES | Genes involved in Glycoprotein hormones |
0.0 | 0.7 | REACTOME_SIGNALING_BY_BMP | Genes involved in Signaling by BMP |
0.0 | 2.6 | REACTOME_PEPTIDE_CHAIN_ELONGATION | Genes involved in Peptide chain elongation |
0.0 | 0.2 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
0.0 | 1.1 | REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT | Genes involved in Mitochondrial Protein Import |
0.0 | 0.3 | REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX | Genes involved in Degradation of the extracellular matrix |
0.0 | 0.5 | REACTOME_FORMATION_OF_TRANSCRIPTION_COUPLED_NER_TC_NER_REPAIR_COMPLEX | Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex |
0.0 | 0.1 | REACTOME_IL_6_SIGNALING | Genes involved in Interleukin-6 signaling |
0.0 | 0.2 | REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
0.0 | 0.3 | REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS | Genes involved in Amine compound SLC transporters |
0.0 | 0.1 | REACTOME_TRYPTOPHAN_CATABOLISM | Genes involved in Tryptophan catabolism |
0.0 | 0.3 | REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
0.0 | 0.3 | REACTOME_GLUTATHIONE_CONJUGATION | Genes involved in Glutathione conjugation |
0.0 | 0.4 | REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
0.0 | 0.1 | REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
0.0 | 0.1 | REACTOME_CDT1_ASSOCIATION_WITH_THE_CDC6_ORC_ORIGIN_COMPLEX | Genes involved in CDT1 association with the CDC6:ORC:origin complex |
0.0 | 0.1 | REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
0.0 | 0.2 | REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
0.0 | 0.8 | REACTOME_ANTIGEN_PROCESSING_CROSS_PRESENTATION | Genes involved in Antigen processing-Cross presentation |
0.0 | 1.8 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
0.0 | 0.2 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |