Motif ID: Foxc2

Z-value: 0.519


Transcription factors associated with Foxc2:

Gene SymbolEntrez IDGene Name
Foxc2 ENSMUSG00000046714.6 Foxc2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxc2mm10_v2_chr8_+_121116163_1211161770.153.6e-01Click!


Activity profile for motif Foxc2.

activity profile for motif Foxc2


Sorted Z-values histogram for motif Foxc2

Sorted Z-values for motif Foxc2



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxc2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_84773381 4.148 ENSMUST00000109764.1
Nfix
nuclear factor I/X
chr9_+_53850243 3.942 ENSMUST00000048485.5
Sln
sarcolipin
chr4_+_48049080 3.240 ENSMUST00000153369.1
Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr4_-_87806296 2.435 ENSMUST00000126353.1
ENSMUST00000149357.1
Mllt3

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

chr17_+_3532554 1.811 ENSMUST00000168560.1
Cldn20
claudin 20
chr2_-_62483637 1.693 ENSMUST00000136686.1
ENSMUST00000102733.3
Gcg

glucagon

chr1_+_177444653 1.642 ENSMUST00000094276.3
Zbtb18
zinc finger and BTB domain containing 18
chr1_-_97977233 1.429 ENSMUST00000161567.1
Pam
peptidylglycine alpha-amidating monooxygenase
chr16_+_43363855 1.365 ENSMUST00000156367.1
Zbtb20
zinc finger and BTB domain containing 20
chr16_+_43364145 1.165 ENSMUST00000148775.1
Zbtb20
zinc finger and BTB domain containing 20
chr2_-_77519565 1.083 ENSMUST00000111830.2
Zfp385b
zinc finger protein 385B
chr12_-_31950170 1.057 ENSMUST00000176520.1
Hbp1
high mobility group box transcription factor 1
chr6_+_17491216 1.052 ENSMUST00000080469.5
Met
met proto-oncogene
chr12_-_31950210 1.046 ENSMUST00000176084.1
ENSMUST00000176103.1
ENSMUST00000167458.2
Hbp1


high mobility group box transcription factor 1


chr16_-_74411292 0.990 ENSMUST00000117200.1
Robo2
roundabout homolog 2 (Drosophila)
chr16_-_22439719 0.982 ENSMUST00000079601.6
Etv5
ets variant gene 5
chr6_+_8520008 0.970 ENSMUST00000162567.1
ENSMUST00000161217.1
Glcci1

glucocorticoid induced transcript 1

chr5_-_111761697 0.931 ENSMUST00000129146.1
ENSMUST00000137398.1
ENSMUST00000129065.1
E130006D01Rik


RIKEN cDNA E130006D01 gene


chr13_+_40859768 0.925 ENSMUST00000110191.2
Gcnt2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr4_-_87806276 0.866 ENSMUST00000148059.1
Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr11_+_32000452 0.865 ENSMUST00000020537.2
ENSMUST00000109409.1
Nsg2

neuron specific gene family member 2

chr1_+_179546303 0.836 ENSMUST00000040706.8
Cnst
consortin, connexin sorting protein
chr3_+_53488677 0.832 ENSMUST00000029307.3
Stoml3
stomatin (Epb7.2)-like 3
chr2_-_45110336 0.784 ENSMUST00000028229.6
ENSMUST00000152232.1
Zeb2

zinc finger E-box binding homeobox 2

chr7_+_27591513 0.768 ENSMUST00000108344.2
Akt2
thymoma viral proto-oncogene 2
chr4_+_97777606 0.746 ENSMUST00000075448.6
ENSMUST00000092532.6
Nfia

nuclear factor I/A

chr8_-_64205970 0.715 ENSMUST00000066166.4
Tll1
tolloid-like
chr12_-_31950535 0.703 ENSMUST00000172314.2
Hbp1
high mobility group box transcription factor 1
chr9_+_70207342 0.689 ENSMUST00000034745.7
Myo1e
myosin IE
chr7_+_24271568 0.668 ENSMUST00000032696.6
Zfp93
zinc finger protein 93
chr13_-_83729544 0.650 ENSMUST00000181705.1
Gm26803
predicted gene, 26803
chr3_-_123672321 0.620 ENSMUST00000172537.1
ENSMUST00000029602.6
Ndst3

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3

chr17_+_70522083 0.614 ENSMUST00000148486.1
ENSMUST00000133717.1
Dlgap1

discs, large (Drosophila) homolog-associated protein 1

chr10_+_60106452 0.609 ENSMUST00000165024.2
Spock2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
chr8_+_66386292 0.590 ENSMUST00000039540.5
ENSMUST00000110253.2
March1

membrane-associated ring finger (C3HC4) 1

chr3_-_146781351 0.586 ENSMUST00000005164.7
Prkacb
protein kinase, cAMP dependent, catalytic, beta
chr2_-_73312701 0.549 ENSMUST00000058615.9
Cir1
corepressor interacting with RBPJ, 1
chr2_+_25180737 0.547 ENSMUST00000104999.2
Nrarp
Notch-regulated ankyrin repeat protein
chr1_+_9848375 0.522 ENSMUST00000097826.4
Sgk3
serum/glucocorticoid regulated kinase 3
chr11_+_32000496 0.513 ENSMUST00000093219.3
Nsg2
neuron specific gene family member 2
chr17_+_70522149 0.513 ENSMUST00000140728.1
Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr1_-_179546261 0.506 ENSMUST00000027769.5
Tfb2m
transcription factor B2, mitochondrial
chr2_-_65529275 0.495 ENSMUST00000126837.1
Scn3a
sodium channel, voltage-gated, type III, alpha
chr13_+_42681513 0.492 ENSMUST00000149235.1
Phactr1
phosphatase and actin regulator 1
chr2_-_177267036 0.486 ENSMUST00000108963.1
Gm14409
predicted gene 14409
chr10_-_68278713 0.483 ENSMUST00000020106.7
Arid5b
AT rich interactive domain 5B (MRF1-like)
chr13_-_12464925 0.481 ENSMUST00000124888.1
Lgals8
lectin, galactose binding, soluble 8
chrX_+_163911401 0.474 ENSMUST00000140845.1
Ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr3_+_135825648 0.458 ENSMUST00000180196.1
Slc39a8
solute carrier family 39 (metal ion transporter), member 8
chr18_-_54990124 0.453 ENSMUST00000064763.5
Zfp608
zinc finger protein 608
chr6_+_92940572 0.452 ENSMUST00000181145.1
ENSMUST00000181840.1
9530026P05Rik

RIKEN cDNA 9530026P05 gene

chr7_-_44849075 0.448 ENSMUST00000047085.8
Tbc1d17
TBC1 domain family, member 17
chr1_+_51289106 0.441 ENSMUST00000051572.6
Sdpr
serum deprivation response
chr14_-_24486994 0.432 ENSMUST00000026322.7
Polr3a
polymerase (RNA) III (DNA directed) polypeptide A
chr2_-_7395879 0.429 ENSMUST00000182404.1
Celf2
CUGBP, Elav-like family member 2
chrX_+_71663665 0.421 ENSMUST00000070449.5
Gpr50
G-protein-coupled receptor 50
chr7_+_82175156 0.410 ENSMUST00000180243.1
Sh3gl3
SH3-domain GRB2-like 3
chr3_+_94837702 0.396 ENSMUST00000107266.1
ENSMUST00000042402.5
ENSMUST00000107269.1
Pogz


pogo transposable element with ZNF domain


chr3_+_63295815 0.395 ENSMUST00000029400.1
Mme
membrane metallo endopeptidase
chr4_-_118409219 0.383 ENSMUST00000075406.5
Szt2
seizure threshold 2
chr19_-_42086338 0.382 ENSMUST00000051772.8
Morn4
MORN repeat containing 4
chr1_+_9848270 0.374 ENSMUST00000171265.1
Sgk3
serum/glucocorticoid regulated kinase 3
chr12_+_71016658 0.369 ENSMUST00000125125.1
Arid4a
AT rich interactive domain 4A (RBP1-like)
chr1_-_156035891 0.366 ENSMUST00000126448.1
Tor1aip1
torsin A interacting protein 1
chr10_-_41303171 0.365 ENSMUST00000043814.3
Fig4
FIG4 homolog (S. cerevisiae)
chr1_-_156034826 0.361 ENSMUST00000141878.1
ENSMUST00000123705.1
Tor1aip1

torsin A interacting protein 1

chr6_+_34709610 0.352 ENSMUST00000031775.6
Cald1
caldesmon 1
chr4_+_102741287 0.340 ENSMUST00000097948.2
Sgip1
SH3-domain GRB2-like (endophilin) interacting protein 1
chr4_-_34882919 0.336 ENSMUST00000098163.2
ENSMUST00000047950.5
Zfp292

zinc finger protein 292

chr1_-_156036473 0.329 ENSMUST00000097527.3
ENSMUST00000027738.7
Tor1aip1

torsin A interacting protein 1

chr16_-_22657165 0.314 ENSMUST00000089925.3
Dgkg
diacylglycerol kinase, gamma
chr2_-_51972990 0.308 ENSMUST00000145481.1
ENSMUST00000112705.2
Nmi

N-myc (and STAT) interactor

chr16_-_34263179 0.303 ENSMUST00000114949.1
ENSMUST00000114954.1
Kalrn

kalirin, RhoGEF kinase

chr5_+_25247344 0.295 ENSMUST00000114950.1
Galnt11
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11
chr3_+_68584154 0.292 ENSMUST00000182997.1
Schip1
schwannomin interacting protein 1
chr3_+_94837533 0.284 ENSMUST00000107270.2
Pogz
pogo transposable element with ZNF domain
chr4_-_127970951 0.282 ENSMUST00000030614.2
CK137956
cDNA sequence CK137956
chr10_+_38965515 0.281 ENSMUST00000019992.5
Lama4
laminin, alpha 4
chr10_-_93310963 0.275 ENSMUST00000151153.1
Elk3
ELK3, member of ETS oncogene family
chr2_+_4718145 0.264 ENSMUST00000056914.6
Bend7
BEN domain containing 7
chr17_+_7925990 0.254 ENSMUST00000036370.7
Tagap
T cell activation Rho GTPase activating protein
chr4_+_148591482 0.251 ENSMUST00000006611.8
Srm
spermidine synthase
chr5_-_122988533 0.245 ENSMUST00000086200.4
ENSMUST00000156474.1
Kdm2b

lysine (K)-specific demethylase 2B

chr7_+_44849581 0.238 ENSMUST00000150335.1
ENSMUST00000107882.1
Akt1s1

AKT1 substrate 1 (proline-rich)

chr2_-_51973219 0.229 ENSMUST00000028314.2
Nmi
N-myc (and STAT) interactor
chr5_-_122989260 0.225 ENSMUST00000118027.1
Kdm2b
lysine (K)-specific demethylase 2B
chr12_-_101958148 0.197 ENSMUST00000159883.1
ENSMUST00000160251.1
ENSMUST00000161011.1
ENSMUST00000021606.5
Atxn3



ataxin 3



chr2_+_91730127 0.190 ENSMUST00000099712.3
ENSMUST00000111317.2
ENSMUST00000111316.2
ENSMUST00000045705.7
Ambra1



autophagy/beclin 1 regulator 1



chr5_-_122989086 0.186 ENSMUST00000046073.9
Kdm2b
lysine (K)-specific demethylase 2B
chr16_-_34262945 0.183 ENSMUST00000114953.1
Kalrn
kalirin, RhoGEF kinase
chr10_-_93311073 0.172 ENSMUST00000008542.5
Elk3
ELK3, member of ETS oncogene family
chr1_-_156034800 0.170 ENSMUST00000169241.1
Tor1aip1
torsin A interacting protein 1
chr9_+_70679016 0.166 ENSMUST00000144537.1
Adam10
a disintegrin and metallopeptidase domain 10
chr11_-_69662564 0.156 ENSMUST00000129224.1
ENSMUST00000155200.1
Mpdu1

mannose-P-dolichol utilization defect 1

chr13_-_30974023 0.152 ENSMUST00000021785.6
Exoc2
exocyst complex component 2
chr14_-_55643251 0.149 ENSMUST00000120041.1
ENSMUST00000121937.1
ENSMUST00000133707.1
ENSMUST00000002391.8
ENSMUST00000121791.1
Tm9sf1




transmembrane 9 superfamily member 1




chr7_+_44849216 0.135 ENSMUST00000054343.8
Akt1s1
AKT1 substrate 1 (proline-rich)
chr4_+_114680769 0.129 ENSMUST00000146346.1
Gm12829
predicted gene 12829
chr1_+_43445736 0.129 ENSMUST00000086421.5
ENSMUST00000114744.1
Nck2

non-catalytic region of tyrosine kinase adaptor protein 2

chr14_-_70766598 0.120 ENSMUST00000167242.1
ENSMUST00000022696.6
Xpo7

exportin 7

chr16_-_4880284 0.115 ENSMUST00000037843.6
Ubald1
UBA-like domain containing 1
chr6_+_30541582 0.115 ENSMUST00000096066.4
Cpa2
carboxypeptidase A2, pancreatic
chr7_+_27195781 0.112 ENSMUST00000108379.1
ENSMUST00000179391.1
BC024978

cDNA sequence BC024978

chr9_+_55326913 0.112 ENSMUST00000085754.3
ENSMUST00000034862.4
AI118078

expressed sequence AI118078

chr11_-_107348130 0.110 ENSMUST00000134763.1
Pitpnc1
phosphatidylinositol transfer protein, cytoplasmic 1
chr11_+_87699897 0.106 ENSMUST00000040089.4
Rnf43
ring finger protein 43
chrX_-_94123087 0.105 ENSMUST00000113925.1
Zfx
zinc finger protein X-linked
chr4_+_102430047 0.096 ENSMUST00000172616.1
Pde4b
phosphodiesterase 4B, cAMP specific
chr1_+_156035705 0.089 ENSMUST00000111754.2
ENSMUST00000133152.1
Tor1aip2

torsin A interacting protein 2

chr10_-_61979073 0.085 ENSMUST00000105453.1
ENSMUST00000105452.2
ENSMUST00000105454.2
Col13a1


collagen, type XIII, alpha 1


chr9_+_13619990 0.073 ENSMUST00000159294.1
Maml2
mastermind like 2 (Drosophila)
chr8_+_68276567 0.059 ENSMUST00000066594.3
Sh2d4a
SH2 domain containing 4A
chr6_+_15185203 0.046 ENSMUST00000154448.1
Foxp2
forkhead box P2
chr11_+_78465697 0.044 ENSMUST00000001126.3
Slc46a1
solute carrier family 46, member 1
chr14_+_61607455 0.039 ENSMUST00000051184.8
Kcnrg
potassium channel regulator
chr18_+_61105561 0.027 ENSMUST00000025523.6
Csf1r
colony stimulating factor 1 receptor
chr17_-_79896028 0.018 ENSMUST00000068282.5
ENSMUST00000112437.1
Atl2

atlastin GTPase 2

chr6_-_137571007 0.015 ENSMUST00000100841.2
Eps8
epidermal growth factor receptor pathway substrate 8
chr1_+_156036133 0.013 ENSMUST00000128941.1
Tor1aip2
torsin A interacting protein 2
chr19_+_44992127 0.010 ENSMUST00000179305.1
Sema4g
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr7_+_44848991 0.004 ENSMUST00000107885.1
Akt1s1
AKT1 substrate 1 (proline-rich)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.2 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
1.0 3.9 GO:1901894 regulation of calcium-transporting ATPase activity(GO:1901894)
0.3 1.0 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.3 2.8 GO:0010745 negative regulation of macrophage derived foam cell differentiation(GO:0010745)
0.3 0.8 GO:0090004 positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.2 1.7 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072366)
0.2 4.1 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.2 3.3 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.2 1.0 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.2 0.5 GO:1902524 interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.2 0.9 GO:0036438 maintenance of lens transparency(GO:0036438)
0.2 1.1 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.1 0.4 GO:0071492 cellular response to UV-A(GO:0071492)
0.1 0.7 GO:0021993 initiation of neural tube closure(GO:0021993)
0.1 0.8 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.1 0.8 GO:0097473 cellular response to light intensity(GO:0071484) cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473)
0.1 1.2 GO:0071763 nuclear membrane organization(GO:0071763)
0.1 1.4 GO:0009404 toxin metabolic process(GO:0009404)
0.1 0.6 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.1 0.5 GO:0046684 response to pyrethroid(GO:0046684)
0.1 1.1 GO:0070842 aggresome assembly(GO:0070842)
0.1 0.5 GO:0002317 plasma cell differentiation(GO:0002317)
0.1 0.4 GO:1901668 regulation of superoxide dismutase activity(GO:1901668)
0.1 0.7 GO:0072015 glomerular basement membrane development(GO:0032836) glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.1 3.0 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 0.6 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 0.5 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.1 0.3 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.1 0.4 GO:0034773 histone H4-K20 trimethylation(GO:0034773) establishment of Sertoli cell barrier(GO:0097368)
0.1 0.5 GO:0061368 maternal process involved in parturition(GO:0060137) behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.1 1.4 GO:0048268 clathrin coat assembly(GO:0048268)
0.1 0.5 GO:0060613 fat pad development(GO:0060613)
0.1 0.7 GO:0072189 ureter development(GO:0072189)
0.1 0.6 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.0 0.3 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 0.5 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.0 0.4 GO:0031642 negative regulation of myelination(GO:0031642)
0.0 0.7 GO:0051382 kinetochore assembly(GO:0051382)
0.0 0.5 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0 0.3 GO:0018243 protein O-linked glycosylation via threonine(GO:0018243)
0.0 0.6 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0 0.1 GO:1903898 positive regulation of translation in response to endoplasmic reticulum stress(GO:0036493) negative regulation of PERK-mediated unfolded protein response(GO:1903898)
0.0 0.4 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.0 0.2 GO:0042117 monocyte activation(GO:0042117)
0.0 0.2 GO:0001927 exocyst assembly(GO:0001927)
0.0 0.9 GO:2001240 negative regulation of signal transduction in absence of ligand(GO:1901099) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.0 0.4 GO:0045792 negative regulation of cell size(GO:0045792)
0.0 0.1 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.0 1.6 GO:0021766 hippocampus development(GO:0021766)
0.0 0.2 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.0 0.3 GO:0001553 luteinization(GO:0001553)
0.0 0.0 GO:0015886 heme transport(GO:0015886)
0.0 0.2 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 0.3 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.4 GO:0006376 mRNA splice site selection(GO:0006376)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.9 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 0.7 GO:0032437 cuticular plate(GO:0032437)
0.1 0.4 GO:1990130 Iml1 complex(GO:1990130)
0.1 3.3 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.8 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.6 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.4 GO:0030478 actin cap(GO:0030478)
0.0 0.4 GO:0032426 stereocilium tip(GO:0032426)
0.0 0.4 GO:0031931 TORC1 complex(GO:0031931)
0.0 1.6 GO:0045171 intercellular bridge(GO:0045171)
0.0 0.5 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 1.0 GO:0030673 axolemma(GO:0030673)
0.0 0.3 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 1.4 GO:0030667 secretory granule membrane(GO:0030667)
0.0 0.4 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.6 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.1 GO:0012506 vesicle membrane(GO:0012506)
0.0 1.1 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.2 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.3 GO:0005605 basal lamina(GO:0005605)
0.0 0.2 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 0.5 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.3 0.9 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.3 1.1 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.2 1.4 GO:0032051 clathrin light chain binding(GO:0032051)
0.2 0.6 GO:0042328 heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328)
0.1 0.4 GO:0008502 melatonin receptor activity(GO:0008502)
0.1 0.5 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.1 0.4 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.1 1.0 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 3.2 GO:0001223 transcription coactivator binding(GO:0001223)
0.1 0.8 GO:0071253 connexin binding(GO:0071253)
0.1 0.4 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.1 0.9 GO:0017081 chloride channel regulator activity(GO:0017081)
0.1 0.6 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 1.2 GO:0005521 lamin binding(GO:0005521)
0.0 0.7 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.3 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.2 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 1.7 GO:0005179 hormone activity(GO:0005179)
0.0 0.5 GO:0031402 sodium ion binding(GO:0031402)
0.0 0.6 GO:0042287 MHC protein binding(GO:0042287)
0.0 0.4 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 0.8 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.5 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.5 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.3 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.0 GO:0015232 heme transporter activity(GO:0015232)
0.0 1.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 2.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.1 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.6 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 1.0 GO:0002039 p53 binding(GO:0002039)
0.0 0.1 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.2 ST_GA12_PATHWAY G alpha 12 Pathway
0.1 2.8 PID_MYC_PATHWAY C-MYC pathway
0.0 2.2 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.3 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 1.1 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.0 0.5 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.6 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 0.8 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.0 0.6 NABA_PROTEOGLYCANS Genes encoding proteoglycans

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.1 1.8 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 0.8 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 2.9 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.5 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 1.1 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 0.5 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 1.1 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.6 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.4 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.4 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.3 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.8 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.2 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.4 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction