Motif ID: Lhx3

Z-value: 0.523


Transcription factors associated with Lhx3:

Gene SymbolEntrez IDGene Name
Lhx3 ENSMUSG00000026934.9 Lhx3



Activity profile for motif Lhx3.

activity profile for motif Lhx3


Sorted Z-values histogram for motif Lhx3

Sorted Z-values for motif Lhx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_103827922 3.573 ENSMUST00000023934.6
ENSMUST00000153218.1
Hbb-bs

hemoglobin, beta adult s chain

chr7_-_45103747 3.568 ENSMUST00000003512.7
Fcgrt
Fc receptor, IgG, alpha chain transporter
chr18_+_57468478 2.879 ENSMUST00000091892.2
Ctxn3
cortexin 3
chr4_+_118961578 2.543 ENSMUST00000058651.4
Lao1
L-amino acid oxidase 1
chr14_+_80000292 2.510 ENSMUST00000088735.3
Olfm4
olfactomedin 4
chr13_+_49608030 2.204 ENSMUST00000021822.5
Ogn
osteoglycin
chr3_+_151437887 2.167 ENSMUST00000046977.7
Eltd1
EGF, latrophilin seven transmembrane domain containing 1
chr1_+_177444653 1.701 ENSMUST00000094276.3
Zbtb18
zinc finger and BTB domain containing 18
chr13_-_101692624 1.670 ENSMUST00000035532.6
Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr8_-_21906412 1.477 ENSMUST00000051965.4
Defb11
defensin beta 11
chr1_-_158356258 1.460 ENSMUST00000004133.8
Brinp2
bone morphogenic protein/retinoic acid inducible neural-specific 2
chr10_+_36506814 1.430 ENSMUST00000167191.1
ENSMUST00000058738.4
Hs3st5

heparan sulfate (glucosamine) 3-O-sulfotransferase 5

chr2_-_33086366 1.249 ENSMUST00000049618.2
Garnl3
GTPase activating RANGAP domain-like 3
chr2_-_160619971 1.241 ENSMUST00000109473.1
Gm14221
predicted gene 14221
chr2_-_33087169 1.239 ENSMUST00000102810.3
Garnl3
GTPase activating RANGAP domain-like 3
chr5_-_62766153 1.198 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr2_+_125136692 1.179 ENSMUST00000099452.2
Ctxn2
cortexin 2
chr5_-_70842617 1.094 ENSMUST00000031119.1
Gabrg1
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1
chr11_+_109543694 1.029 ENSMUST00000106696.1
Arsg
arylsulfatase G
chr14_-_108914237 0.980 ENSMUST00000100322.2
Slitrk1
SLIT and NTRK-like family, member 1
chr10_-_62507737 0.972 ENSMUST00000020271.6
Srgn
serglycin
chr17_-_36032682 0.918 ENSMUST00000102678.4
H2-T23
histocompatibility 2, T region locus 23
chr18_+_37477768 0.914 ENSMUST00000051442.5
Pcdhb16
protocadherin beta 16
chr17_-_67950908 0.914 ENSMUST00000164647.1
Arhgap28
Rho GTPase activating protein 28
chr4_+_102589687 0.816 ENSMUST00000097949.4
ENSMUST00000106901.1
Pde4b

phosphodiesterase 4B, cAMP specific

chr6_+_34780412 0.732 ENSMUST00000115016.1
ENSMUST00000115017.1
Agbl3

ATP/GTP binding protein-like 3

chr2_+_82053222 0.706 ENSMUST00000047527.7
Zfp804a
zinc finger protein 804A
chrX_+_166344692 0.668 ENSMUST00000112223.1
ENSMUST00000112224.1
ENSMUST00000112229.2
ENSMUST00000112228.1
ENSMUST00000112227.2
ENSMUST00000112226.2
Gpm6b





glycoprotein m6b





chr19_+_26623419 0.612 ENSMUST00000176584.1
Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr10_-_53647080 0.581 ENSMUST00000169866.1
Fam184a
family with sequence similarity 184, member A
chr3_-_57294880 0.579 ENSMUST00000171384.1
Tm4sf1
transmembrane 4 superfamily member 1
chr3_+_66985680 0.569 ENSMUST00000065047.6
Rsrc1
arginine/serine-rich coiled-coil 1
chrX_-_143933204 0.564 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
Dcx


doublecortin


chr2_+_36230426 0.533 ENSMUST00000062069.5
Ptgs1
prostaglandin-endoperoxide synthase 1
chr4_+_136143497 0.504 ENSMUST00000008016.2
Id3
inhibitor of DNA binding 3
chr5_+_66968961 0.501 ENSMUST00000132991.1
Limch1
LIM and calponin homology domains 1
chr5_-_118244861 0.461 ENSMUST00000117177.1
ENSMUST00000133372.1
ENSMUST00000154786.1
ENSMUST00000121369.1
Rnft2



ring finger protein, transmembrane 2



chrX_+_66653003 0.454 ENSMUST00000036043.4
Slitrk2
SLIT and NTRK-like family, member 2
chr1_-_38821215 0.452 ENSMUST00000039612.4
Lonrf2
LON peptidase N-terminal domain and ring finger 2
chr3_-_116712644 0.434 ENSMUST00000029569.2
Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr9_+_113812547 0.430 ENSMUST00000166734.2
ENSMUST00000111838.2
ENSMUST00000163895.2
Clasp2


CLIP associating protein 2


chr6_+_124304646 0.429 ENSMUST00000112541.2
ENSMUST00000032234.2
Cd163

CD163 antigen

chr11_-_84069179 0.406 ENSMUST00000138208.1
Dusp14
dual specificity phosphatase 14
chr3_+_53845086 0.374 ENSMUST00000108014.1
Gm10985
predicted gene 10985
chr10_+_23797052 0.370 ENSMUST00000133289.1
Slc18b1
solute carrier family 18, subfamily B, member 1
chr4_+_147132038 0.368 ENSMUST00000084149.3
Gm13139
predicted gene 13139
chr3_+_136670076 0.368 ENSMUST00000070198.7
Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chr10_+_75037066 0.356 ENSMUST00000147802.1
ENSMUST00000020391.5
Rab36

RAB36, member RAS oncogene family

chrM_+_9870 0.350 ENSMUST00000084013.1
mt-Nd4l
mitochondrially encoded NADH dehydrogenase 4L
chr16_+_11406618 0.346 ENSMUST00000122168.1
Snx29
sorting nexin 29
chr2_-_164171113 0.343 ENSMUST00000045196.3
Kcns1
K+ voltage-gated channel, subfamily S, 1
chrM_-_14060 0.299 ENSMUST00000082419.1
mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr10_-_33624587 0.289 ENSMUST00000160299.1
ENSMUST00000019920.6
Clvs2

clavesin 2

chrM_+_9452 0.276 ENSMUST00000082411.1
mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chr3_+_66985647 0.271 ENSMUST00000162362.1
ENSMUST00000065074.7
Rsrc1

arginine/serine-rich coiled-coil 1

chr13_-_74482943 0.259 ENSMUST00000074369.6
Zfp825
zinc finger protein 825
chr10_+_75037291 0.259 ENSMUST00000139384.1
Rab36
RAB36, member RAS oncogene family
chr10_+_116143881 0.244 ENSMUST00000105271.2
Ptprr
protein tyrosine phosphatase, receptor type, R
chr2_+_23069210 0.242 ENSMUST00000155602.1
Acbd5
acyl-Coenzyme A binding domain containing 5
chrM_+_14138 0.240 ENSMUST00000082421.1
mt-Cytb
mitochondrially encoded cytochrome b
chr1_-_24612700 0.234 ENSMUST00000088336.1
Gm10222
predicted gene 10222
chrX_-_143933089 0.230 ENSMUST00000087313.3
Dcx
doublecortin
chr3_-_41742471 0.220 ENSMUST00000026866.8
Sclt1
sodium channel and clathrin linker 1
chr6_+_96115249 0.216 ENSMUST00000075080.5
Fam19a1
family with sequence similarity 19, member A1
chr3_+_142620596 0.214 ENSMUST00000165774.1
Gbp2
guanylate binding protein 2
chr18_+_60774675 0.214 ENSMUST00000118551.1
Rps14
ribosomal protein S14
chr10_+_5593718 0.205 ENSMUST00000051809.8
Myct1
myc target 1
chr10_+_102158858 0.196 ENSMUST00000138522.1
ENSMUST00000163753.1
ENSMUST00000138016.1
Mgat4c


mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)


chr16_-_55934797 0.187 ENSMUST00000122280.1
ENSMUST00000121703.2
Cep97

centrosomal protein 97

chr16_-_55934845 0.180 ENSMUST00000121129.1
ENSMUST00000023270.7
Cep97

centrosomal protein 97

chr18_+_60774510 0.175 ENSMUST00000025511.3
Rps14
ribosomal protein S14
chr4_-_147809788 0.156 ENSMUST00000105734.3
ENSMUST00000176201.1
Gm13157
Gm20707
predicted gene 13157
predicted gene 20707
chr14_+_69347587 0.147 ENSMUST00000064831.5
Entpd4
ectonucleoside triphosphate diphosphohydrolase 4
chr1_-_36273425 0.133 ENSMUST00000056946.6
Neurl3
neuralized homolog 3 homolog (Drosophila)
chr4_+_146610961 0.122 ENSMUST00000130825.1
Gm13248
predicted gene 13248
chr3_+_41742615 0.121 ENSMUST00000146165.1
ENSMUST00000119572.1
ENSMUST00000108065.2
ENSMUST00000120167.1
ENSMUST00000026867.7
ENSMUST00000026868.7
D3Ertd751e





DNA segment, Chr 3, ERATO Doi 751, expressed





chr19_+_3768112 0.115 ENSMUST00000005518.9
ENSMUST00000113967.1
ENSMUST00000152935.1
ENSMUST00000176262.1
ENSMUST00000176407.1
ENSMUST00000176926.1
ENSMUST00000176512.1
Suv420h1






suppressor of variegation 4-20 homolog 1 (Drosophila)






chr9_+_96258697 0.110 ENSMUST00000179416.1
Tfdp2
transcription factor Dp 2
chrX_-_94123087 0.064 ENSMUST00000113925.1
Zfx
zinc finger protein X-linked
chr3_+_95318782 0.063 ENSMUST00000139866.1
Cers2
ceramide synthase 2
chr19_+_46397009 0.054 ENSMUST00000118440.1
Sufu
suppressor of fused homolog (Drosophila)
chr2_-_84425258 0.048 ENSMUST00000074262.2
Calcrl
calcitonin receptor-like
chr8_-_109251698 0.040 ENSMUST00000079189.3
4922502B01Rik
RIKEN cDNA 4922502B01 gene
chr4_+_145585166 0.037 ENSMUST00000105739.1
ENSMUST00000119718.1
Gm13212

predicted gene 13212

chr6_+_37870786 0.027 ENSMUST00000120428.1
ENSMUST00000031859.7
Trim24

tripartite motif-containing 24

chr12_+_71170589 0.026 ENSMUST00000129376.1
2700049A03Rik
RIKEN cDNA 2700049A03 gene
chr4_+_147492417 0.012 ENSMUST00000105721.2
Gm13152
predicted gene 13152
chr5_-_62765618 0.009 ENSMUST00000159470.1
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr4_-_14621805 0.001 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.3 0.9 GO:2000564 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.2 1.4 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.2 0.9 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.2 1.7 GO:0010459 negative regulation of heart rate(GO:0010459)
0.1 0.5 GO:0010700 negative regulation of norepinephrine secretion(GO:0010700)
0.1 0.4 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244) regulation of connective tissue replacement(GO:1905203)
0.1 0.7 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.1 0.7 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.1 0.4 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.1 0.6 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.1 0.8 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 0.4 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.1 0.2 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.1 0.2 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.1 0.8 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 2.5 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 0.2 GO:0033762 response to glucagon(GO:0033762)
0.0 0.9 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 1.1 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 2.5 GO:0009063 cellular amino acid catabolic process(GO:0009063)
0.0 0.2 GO:0030242 pexophagy(GO:0030242)
0.0 0.4 GO:1902018 negative regulation of cilium assembly(GO:1902018)
0.0 1.5 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 0.5 GO:0030903 notochord development(GO:0030903)
0.0 0.4 GO:0006953 acute-phase response(GO:0006953)
0.0 0.8 GO:0046677 response to antibiotic(GO:0046677)
0.0 0.1 GO:1903976 negative regulation of glial cell migration(GO:1903976)
0.0 0.4 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.3 GO:1902259 regulation of delayed rectifier potassium channel activity(GO:1902259)
0.0 0.1 GO:0021775 smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
0.0 0.2 GO:0044406 adhesion of symbiont to host(GO:0044406)
0.0 0.0 GO:0034285 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.0 0.4 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 1.5 GO:0042742 defense response to bacterium(GO:0042742)
0.0 1.0 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 1.3 GO:0021549 cerebellum development(GO:0021549)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.6 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.2 2.5 GO:0042581 specific granule(GO:0042581)
0.1 1.0 GO:0042629 mast cell granule(GO:0042629)
0.1 0.4 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.1 0.9 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 1.7 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 0.4 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.1 GO:0097637 intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637)
0.0 0.6 GO:0071564 npBAF complex(GO:0071564)
0.0 0.8 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 1.1 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.9 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.2 GO:0071439 clathrin complex(GO:0071439)
0.0 0.2 GO:0045275 respiratory chain complex III(GO:0045275)
0.0 0.2 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
0.0 0.6 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.3 GO:0070469 respiratory chain(GO:0070469)
0.0 0.5 GO:0001750 photoreceptor outer segment(GO:0001750)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.6 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.8 2.5 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.7 3.6 GO:0019770 IgG receptor activity(GO:0019770)
0.4 1.7 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.2 1.4 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.1 0.9 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.1 1.0 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.1 0.4 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 1.1 GO:0050811 GABA-A receptor activity(GO:0004890) GABA receptor binding(GO:0050811)
0.0 0.7 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.2 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.4 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.9 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.4 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.2 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.8 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 1.2 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.1 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.0 2.2 GO:0008083 growth factor activity(GO:0008083)
0.0 0.4 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.3 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.4 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.0 0.3 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 1.0 GO:0005518 collagen binding(GO:0005518)
0.0 0.5 GO:0004601 peroxidase activity(GO:0004601)
0.0 0.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.6 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.2 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 1.7 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.8 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.4 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.2 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.1 1.7 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.1 1.0 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 1.4 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 1.2 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 2.1 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.0 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.2 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.4 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules