Motif ID: Bbx

Z-value: 0.317


Transcription factors associated with Bbx:

Gene SymbolEntrez IDGene Name
Bbx ENSMUSG00000022641.9 Bbx

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Bbxmm10_v2_chr16_-_50432340_50432409-0.143.7e-01Click!


Activity profile for motif Bbx.

activity profile for motif Bbx


Sorted Z-values histogram for motif Bbx

Sorted Z-values for motif Bbx



Network of associatons between targets according to the STRING database.



First level regulatory network of Bbx

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_+_21111452 1.940 ENSMUST00000075132.6
Cdh12
cadherin 12
chr5_-_146585239 1.176 ENSMUST00000036211.6
Gpr12
G-protein coupled receptor 12
chr18_+_37421418 1.041 ENSMUST00000053073.4
Pcdhb11
protocadherin beta 11
chrX_+_159708593 0.844 ENSMUST00000080394.6
Sh3kbp1
SH3-domain kinase binding protein 1
chr10_+_86021961 0.664 ENSMUST00000130320.1
Fbxo7
F-box protein 7
chr13_+_49608030 0.631 ENSMUST00000021822.5
Ogn
osteoglycin
chr2_+_136892168 0.610 ENSMUST00000099311.2
Slx4ip
SLX4 interacting protein
chrX_+_140367494 0.547 ENSMUST00000141660.1
Frmpd3
FERM and PDZ domain containing 3
chr1_+_180111339 0.542 ENSMUST00000145181.1
Cdc42bpa
CDC42 binding protein kinase alpha
chr13_-_52530827 0.519 ENSMUST00000057442.6
Diras2
DIRAS family, GTP-binding RAS-like 2
chr8_-_41054771 0.499 ENSMUST00000093534.4
Mtus1
mitochondrial tumor suppressor 1
chr11_+_105146893 0.476 ENSMUST00000100338.1
Gm10842
predicted gene 10842
chr16_+_20693263 0.384 ENSMUST00000149543.1
ENSMUST00000118919.1
Fam131a

family with sequence similarity 131, member A

chrX_-_107816238 0.371 ENSMUST00000120722.1
2610002M06Rik
RIKEN cDNA 2610002M06 gene
chrX_-_150814265 0.353 ENSMUST00000026302.6
ENSMUST00000129768.1
ENSMUST00000112699.2
Maged2


melanoma antigen, family D, 2


chr10_+_84622365 0.326 ENSMUST00000077175.5
Polr3b
polymerase (RNA) III (DNA directed) polypeptide B
chr12_+_103388656 0.264 ENSMUST00000101094.2
ENSMUST00000021620.6
Otub2

OTU domain, ubiquitin aldehyde binding 2

chr8_+_45658273 0.249 ENSMUST00000153798.1
Sorbs2
sorbin and SH3 domain containing 2
chr1_-_163725123 0.216 ENSMUST00000159679.1
Mettl11b
methyltransferase like 11B
chr8_+_45658731 0.166 ENSMUST00000143820.1
ENSMUST00000132139.1
Sorbs2

sorbin and SH3 domain containing 2

chr8_+_45658666 0.150 ENSMUST00000134675.1
ENSMUST00000139869.1
ENSMUST00000126067.1
Sorbs2


sorbin and SH3 domain containing 2


chr4_+_80910646 0.145 ENSMUST00000055922.3
Lurap1l
leucine rich adaptor protein 1-like
chr6_+_124304646 0.140 ENSMUST00000112541.2
ENSMUST00000032234.2
Cd163

CD163 antigen

chr17_+_57358682 0.128 ENSMUST00000086763.5
ENSMUST00000004850.7
Emr1

EGF-like module containing, mucin-like, hormone receptor-like sequence 1

chr5_-_108675569 0.125 ENSMUST00000051757.7
Slc26a1
solute carrier family 26 (sulfate transporter), member 1
chr2_-_152830615 0.097 ENSMUST00000146380.1
ENSMUST00000134902.1
ENSMUST00000134357.1
ENSMUST00000109820.3
Bcl2l1



BCL2-like 1



chr8_+_70616816 0.062 ENSMUST00000052437.3
Lrrc25
leucine rich repeat containing 25
chr3_+_16183177 0.058 ENSMUST00000108345.2
ENSMUST00000108346.2
Ythdf3

YTH domain family 3

chr2_-_152830266 0.049 ENSMUST00000140436.1
Bcl2l1
BCL2-like 1
chr17_+_40811089 0.024 ENSMUST00000024721.7
Rhag
Rhesus blood group-associated A glycoprotein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:1903207 neuron death in response to hydrogen peroxide(GO:0036476) regulation of hydrogen peroxide-induced neuron death(GO:1903207) negative regulation of hydrogen peroxide-induced neuron death(GO:1903208)
0.1 0.4 GO:0070294 renal sodium ion absorption(GO:0070294)
0.0 0.1 GO:0046898 response to cycloheximide(GO:0046898)
0.0 0.3 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.0 1.9 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.5 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.0 0.5 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.0 0.1 GO:0019532 oxalate transport(GO:0019532)
0.0 0.6 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:1990037 Lewy body core(GO:1990037)
0.0 0.3 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.1 GO:0097136 Bcl-2 family protein complex(GO:0097136)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.0 0.3 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.3 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 0.1 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.1 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.8 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.1 1.9 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.8 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.3 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.1 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes