Motif ID: Hnf1b

Z-value: 0.648


Transcription factors associated with Hnf1b:

Gene SymbolEntrez IDGene Name
Hnf1b ENSMUSG00000020679.5 Hnf1b



Activity profile for motif Hnf1b.

activity profile for motif Hnf1b


Sorted Z-values histogram for motif Hnf1b

Sorted Z-values for motif Hnf1b



Network of associatons between targets according to the STRING database.



First level regulatory network of Hnf1b

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_-_53286052 5.825 ENSMUST00000021918.8
Ror2
receptor tyrosine kinase-like orphan receptor 2
chr4_-_106464167 3.536 ENSMUST00000049507.5
Pcsk9
proprotein convertase subtilisin/kexin type 9
chr10_+_4611971 3.117 ENSMUST00000105590.1
ENSMUST00000067086.7
Esr1

estrogen receptor 1 (alpha)

chr10_-_30842765 2.755 ENSMUST00000019924.8
Hey2
hairy/enhancer-of-split related with YRPW motif 2
chr10_-_7212222 2.751 ENSMUST00000015346.5
Cnksr3
Cnksr family member 3
chr2_+_158768083 2.722 ENSMUST00000029183.2
Fam83d
family with sequence similarity 83, member D
chr3_-_150073620 2.621 ENSMUST00000057740.5
Rpsa-ps10
ribosomal protein SA, pseudogene 10
chr14_+_46882854 2.394 ENSMUST00000022386.8
ENSMUST00000100672.3
Samd4

sterile alpha motif domain containing 4

chr9_+_99629496 2.371 ENSMUST00000131095.1
ENSMUST00000078367.5
ENSMUST00000112885.2
Dzip1l


DAZ interacting protein 1-like


chr9_+_15520830 2.320 ENSMUST00000178999.1
Smco4
single-pass membrane protein with coiled-coil domains 4
chr4_-_134767940 2.229 ENSMUST00000037828.6
Ldlrap1
low density lipoprotein receptor adaptor protein 1
chr9_+_99629823 2.059 ENSMUST00000112886.2
Dzip1l
DAZ interacting protein 1-like
chr13_+_4191163 1.965 ENSMUST00000021634.2
Akr1c13
aldo-keto reductase family 1, member C13
chr7_+_100537192 1.905 ENSMUST00000120454.1
Coa4
cytochrome c oxidase assembly factor 4
chr1_-_4880669 1.876 ENSMUST00000078030.3
Gm6104
predicted gene 6104
chr2_+_167777467 1.829 ENSMUST00000139927.1
ENSMUST00000127441.1
Gm14321

predicted gene 14321

chr9_-_106158109 1.772 ENSMUST00000159809.1
ENSMUST00000162562.1
ENSMUST00000036382.6
ENSMUST00000112543.2
Glyctk



glycerate kinase



chr4_+_43957401 1.695 ENSMUST00000030202.7
Glipr2
GLI pathogenesis-related 2
chr17_-_35132050 1.679 ENSMUST00000025249.6
Apom
apolipoprotein M
chr3_-_138131356 1.603 ENSMUST00000029805.8
Mttp
microsomal triglyceride transfer protein
chr15_-_36598019 1.587 ENSMUST00000155116.1
Pabpc1
poly(A) binding protein, cytoplasmic 1
chr7_-_144751968 1.439 ENSMUST00000155175.1
Ano1
anoctamin 1, calcium activated chloride channel
chr10_-_76110956 1.360 ENSMUST00000120757.1
Slc5a4b
solute carrier family 5 (neutral amino acid transporters, system A), member 4b
chr19_+_23723279 1.342 ENSMUST00000067077.1
Gm9938
predicted gene 9938
chr9_-_61914538 1.339 ENSMUST00000008036.7
Rplp1
ribosomal protein, large, P1
chr16_-_16146771 1.259 ENSMUST00000040248.7
Spidr
scaffolding protein involved i DNA repair
chr6_-_128437653 1.249 ENSMUST00000151796.1
Fkbp4
FK506 binding protein 4
chr17_+_47737030 1.249 ENSMUST00000086932.3
Tfeb
transcription factor EB
chr7_+_141216626 1.212 ENSMUST00000141804.1
ENSMUST00000148975.1
Rassf7

Ras association (RalGDS/AF-6) domain family (N-terminal) member 7

chr18_+_4993795 1.203 ENSMUST00000153016.1
Svil
supervillin
chr12_-_87444017 1.192 ENSMUST00000091090.4
2700073G19Rik
RIKEN cDNA 2700073G19 gene
chr11_-_76027726 1.122 ENSMUST00000021207.6
Fam101b
family with sequence similarity 101, member B
chr15_-_103215285 1.096 ENSMUST00000122182.1
ENSMUST00000108813.3
ENSMUST00000127191.1
Cbx5


chromobox 5


chr7_+_141215852 1.070 ENSMUST00000046890.5
ENSMUST00000133763.1
Rassf7

Ras association (RalGDS/AF-6) domain family (N-terminal) member 7

chr11_+_78178105 1.069 ENSMUST00000147819.1
Tlcd1
TLC domain containing 1
chr1_+_58795371 1.032 ENSMUST00000027189.8
Casp8
caspase 8
chr11_+_3983636 1.016 ENSMUST00000078757.1
Gal3st1
galactose-3-O-sulfotransferase 1
chr8_-_92355764 1.011 ENSMUST00000180102.1
ENSMUST00000179421.1
ENSMUST00000179222.1
ENSMUST00000179029.1
4933436C20Rik



RIKEN cDNA 4933436C20 gene



chr3_+_154597352 0.994 ENSMUST00000140644.1
ENSMUST00000144764.1
ENSMUST00000155232.1
Cryz


crystallin, zeta


chr11_+_3983704 0.953 ENSMUST00000063004.7
Gal3st1
galactose-3-O-sulfotransferase 1
chr12_+_87443896 0.878 ENSMUST00000161023.1
ENSMUST00000160488.1
ENSMUST00000077462.7
ENSMUST00000160880.1
Slirp



SRA stem-loop interacting RNA binding protein



chr5_-_121527186 0.852 ENSMUST00000152270.1
Mapkapk5
MAP kinase-activated protein kinase 5
chr4_-_150909428 0.842 ENSMUST00000128075.1
ENSMUST00000105674.1
ENSMUST00000105673.1
Park7


Parkinson disease (autosomal recessive, early onset) 7


chr9_-_71163224 0.829 ENSMUST00000074465.2
Aqp9
aquaporin 9
chr12_+_108605757 0.814 ENSMUST00000109854.2
Evl
Ena-vasodilator stimulated phosphoprotein
chrX_+_52791179 0.787 ENSMUST00000101588.1
Ccdc160
coiled-coil domain containing 160
chr2_-_86347764 0.735 ENSMUST00000099894.2
Olfr1055
olfactory receptor 1055
chr6_+_73248382 0.734 ENSMUST00000064740.6
Suclg1
succinate-CoA ligase, GDP-forming, alpha subunit
chr13_-_55536504 0.685 ENSMUST00000021956.8
Ddx41
DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
chr11_-_11898044 0.678 ENSMUST00000066237.3
Ddc
dopa decarboxylase
chr1_+_19208914 0.676 ENSMUST00000027059.4
Tfap2b
transcription factor AP-2 beta
chr6_+_38918969 0.668 ENSMUST00000003017.6
Tbxas1
thromboxane A synthase 1, platelet
chr13_+_89540636 0.650 ENSMUST00000022108.7
Hapln1
hyaluronan and proteoglycan link protein 1
chr11_-_11898092 0.586 ENSMUST00000178704.1
Ddc
dopa decarboxylase
chr7_-_45062393 0.584 ENSMUST00000129101.1
Prrg2
proline-rich Gla (G-carboxyglutamic acid) polypeptide 2
chr5_-_123666682 0.583 ENSMUST00000149410.1
Clip1
CAP-GLY domain containing linker protein 1
chr8_+_95715901 0.581 ENSMUST00000034096.4
Setd6
SET domain containing 6
chr10_+_63061582 0.555 ENSMUST00000020266.8
ENSMUST00000178684.1
Pbld1

phenazine biosynthesis-like protein domain containing 1

chr7_-_27166732 0.525 ENSMUST00000080058.4
Egln2
EGL nine homolog 2 (C. elegans)
chr5_-_87490869 0.507 ENSMUST00000147854.1
Ugt2a1
UDP glucuronosyltransferase 2 family, polypeptide A1
chr18_-_66022580 0.501 ENSMUST00000143990.1
Lman1
lectin, mannose-binding, 1
chr2_+_151494274 0.450 ENSMUST00000028949.9
ENSMUST00000103160.4
Nsfl1c

NSFL1 (p97) cofactor (p47)

chr7_+_119561699 0.401 ENSMUST00000167935.2
ENSMUST00000130583.1
Acsm2

acyl-CoA synthetase medium-chain family member 2

chr10_-_116549101 0.395 ENSMUST00000164088.1
Cnot2
CCR4-NOT transcription complex, subunit 2
chr1_+_133309778 0.394 ENSMUST00000094557.4
ENSMUST00000183457.1
ENSMUST00000183738.1
ENSMUST00000185157.1
ENSMUST00000184603.1
Golt1a

Kiss1

GOLT1A
golgi transport 1 homolog A (S. cerevisiae)

KiSS-1 metastasis-suppressor

KISS1 isoform e
chr15_-_79285502 0.391 ENSMUST00000165408.1
Baiap2l2
BAI1-associated protein 2-like 2
chr2_+_151494182 0.390 ENSMUST00000089140.6
Nsfl1c
NSFL1 (p97) cofactor (p47)
chr19_-_14598031 0.381 ENSMUST00000167776.2
Tle4
transducin-like enhancer of split 4, homolog of Drosophila E(spl)
chr14_-_20496780 0.381 ENSMUST00000022353.3
Mss51
MSS51 mitochondrial translational activator
chr7_-_28962265 0.374 ENSMUST00000068045.7
Actn4
actinin alpha 4
chr3_-_130730375 0.361 ENSMUST00000079085.6
Rpl34
ribosomal protein L34
chr11_+_110968056 0.352 ENSMUST00000125692.1
Kcnj16
potassium inwardly-rectifying channel, subfamily J, member 16
chr19_-_30549516 0.347 ENSMUST00000025803.8
Dkk1
dickkopf homolog 1 (Xenopus laevis)
chr2_-_155357392 0.325 ENSMUST00000165234.1
ENSMUST00000077626.6
Pigu

phosphatidylinositol glycan anchor biosynthesis, class U

chr15_-_50890396 0.319 ENSMUST00000185183.1
Trps1
trichorhinophalangeal syndrome I (human)
chr12_-_12940600 0.315 ENSMUST00000130990.1
Mycn
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
chr8_+_95332279 0.301 ENSMUST00000034245.8
Usb1
U6 snRNA biogenesis 1
chr2_+_173737492 0.299 ENSMUST00000067530.4
Vapb
vesicle-associated membrane protein, associated protein B and C
chr11_+_78465697 0.293 ENSMUST00000001126.3
Slc46a1
solute carrier family 46, member 1
chrM_+_2743 0.285 ENSMUST00000082392.1
mt-Nd1
mitochondrially encoded NADH dehydrogenase 1
chr3_+_136670076 0.275 ENSMUST00000070198.7
Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chr13_+_83738874 0.232 ENSMUST00000052354.4
C130071C03Rik
RIKEN cDNA C130071C03 gene
chr19_-_14597983 0.232 ENSMUST00000052011.7
Tle4
transducin-like enhancer of split 4, homolog of Drosophila E(spl)
chr5_-_114444036 0.226 ENSMUST00000031560.7
Mmab
methylmalonic aciduria (cobalamin deficiency) type B homolog (human)
chr4_-_117682233 0.223 ENSMUST00000102687.3
Dmap1
DNA methyltransferase 1-associated protein 1
chr14_+_79515618 0.221 ENSMUST00000110835.1
Elf1
E74-like factor 1
chr5_-_114443993 0.218 ENSMUST00000112245.1
Mmab
methylmalonic aciduria (cobalamin deficiency) type B homolog (human)
chr13_+_4233730 0.214 ENSMUST00000081326.6
Akr1c19
aldo-keto reductase family 1, member C19
chr9_+_53771499 0.180 ENSMUST00000048670.8
Slc35f2
solute carrier family 35, member F2
chr7_+_24862193 0.174 ENSMUST00000052897.4
ENSMUST00000170837.2
Gm9844
Gm9844
predicted pseudogene 9844
predicted pseudogene 9844
chr11_+_110968016 0.147 ENSMUST00000106636.1
ENSMUST00000180023.1
Kcnj16

potassium inwardly-rectifying channel, subfamily J, member 16

chr8_-_8690493 0.146 ENSMUST00000048545.8
Arglu1
arginine and glutamate rich 1
chr8_+_117095854 0.137 ENSMUST00000034308.8
ENSMUST00000167370.1
ENSMUST00000176860.1
Bcmo1


beta-carotene 15,15'-monooxygenase


chr15_+_99393610 0.135 ENSMUST00000159531.1
Tmbim6
transmembrane BAX inhibitor motif containing 6
chr4_-_41045381 0.128 ENSMUST00000054945.7
Aqp7
aquaporin 7
chr5_-_100373484 0.123 ENSMUST00000182433.1
Sec31a
Sec31 homolog A (S. cerevisiae)
chr3_-_130730310 0.122 ENSMUST00000062601.7
Rpl34
ribosomal protein L34
chr18_+_35599219 0.105 ENSMUST00000115734.1
Paip2
polyadenylate-binding protein-interacting protein 2
chr6_-_102464667 0.104 ENSMUST00000032159.6
Cntn3
contactin 3
chr3_-_108226598 0.075 ENSMUST00000029486.7
ENSMUST00000156371.1
ENSMUST00000141387.1
Sypl2


synaptophysin-like 2


chrX_+_101376359 0.064 ENSMUST00000119080.1
Gjb1
gap junction protein, beta 1
chr5_-_38491948 0.056 ENSMUST00000129099.1
Slc2a9
solute carrier family 2 (facilitated glucose transporter), member 9
chr3_-_66296807 0.042 ENSMUST00000029419.7
Veph1
ventricular zone expressed PH domain-containing 1
chr17_+_17374332 0.038 ENSMUST00000024620.6
Riok2
RIO kinase 2 (yeast)
chr11_+_118428203 0.028 ENSMUST00000124861.1
C1qtnf1
C1q and tumor necrosis factor related protein 1
chr15_+_85510812 0.026 ENSMUST00000079690.2
Gm4825
predicted pseudogene 4825
chr9_+_54538984 0.016 ENSMUST00000060242.5
ENSMUST00000118413.1
Sh2d7

SH2 domain containing 7

chr7_+_45062429 0.009 ENSMUST00000107830.1
ENSMUST00000003513.3
ENSMUST00000107829.1
ENSMUST00000150609.1
Nosip



nitric oxide synthase interacting protein



chr17_-_71459300 0.008 ENSMUST00000183937.1
Gm4707
predicted gene 4707
chr11_+_23665615 0.008 ENSMUST00000109525.1
ENSMUST00000020520.4
Pus10

pseudouridylate synthase 10


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 5.8 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223)
0.9 2.8 GO:0003195 tricuspid valve formation(GO:0003195)
0.9 3.5 GO:0001920 negative regulation of receptor recycling(GO:0001920) negative regulation of low-density lipoprotein particle clearance(GO:0010989) positive regulation of low-density lipoprotein particle receptor catabolic process(GO:0032805)
0.8 3.1 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.7 2.2 GO:0090118 receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport(GO:0090118)
0.4 1.7 GO:0050748 negative regulation of lipoprotein metabolic process(GO:0050748)
0.4 1.2 GO:0009814 defense response, incompatible interaction(GO:0009814)
0.3 1.6 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.3 1.6 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.3 1.4 GO:0015705 iodide transport(GO:0015705)
0.3 0.8 GO:0050787 glycolate metabolic process(GO:0009441) enzyme active site formation via L-cysteine sulfinic acid(GO:0018323) primary alcohol biosynthetic process(GO:0034309) cellular response to glyoxal(GO:0036471) glycolate biosynthetic process(GO:0046295) detoxification of mercury ion(GO:0050787) negative regulation of TRAIL-activated apoptotic signaling pathway(GO:1903122) regulation of pyrroline-5-carboxylate reductase activity(GO:1903167) positive regulation of pyrroline-5-carboxylate reductase activity(GO:1903168) regulation of tyrosine 3-monooxygenase activity(GO:1903176) positive regulation of tyrosine 3-monooxygenase activity(GO:1903178) L-dopa metabolic process(GO:1903184) L-dopa biosynthetic process(GO:1903185) glyoxal metabolic process(GO:1903189) regulation of L-dopa biosynthetic process(GO:1903195) positive regulation of L-dopa biosynthetic process(GO:1903197) regulation of L-dopa decarboxylase activity(GO:1903198) positive regulation of L-dopa decarboxylase activity(GO:1903200) positive regulation of cellular amino acid biosynthetic process(GO:2000284)
0.3 1.4 GO:1904659 glucose transmembrane transport(GO:1904659)
0.3 1.3 GO:0072757 cellular response to camptothecin(GO:0072757)
0.2 0.7 GO:0097274 urea homeostasis(GO:0097274)
0.2 0.9 GO:0000957 mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
0.2 2.0 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.2 1.3 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.2 0.6 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
0.1 0.6 GO:0044861 protein transport into plasma membrane raft(GO:0044861)
0.1 0.8 GO:0046689 response to mercury ion(GO:0046689)
0.1 0.8 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.1 1.0 GO:0036462 TRAIL-activated apoptotic signaling pathway(GO:0036462)
0.1 1.9 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.1 0.3 GO:1904956 regulation of endodermal cell fate specification(GO:0042663) Wnt signaling pathway involved in somitogenesis(GO:0090244) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) positive regulation of heart induction(GO:1901321) regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066)
0.1 0.7 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.1 0.9 GO:0090400 stress-induced premature senescence(GO:0090400)
0.1 0.3 GO:1902396 protein localization to bicellular tight junction(GO:1902396)
0.1 2.8 GO:2000651 positive regulation of sodium ion transmembrane transporter activity(GO:2000651)
0.1 0.5 GO:0052695 cellular glucuronidation(GO:0052695)
0.1 0.4 GO:0032275 luteinizing hormone secretion(GO:0032275) positive regulation of gonadotropin secretion(GO:0032278)
0.1 0.3 GO:0015886 heme transport(GO:0015886)
0.1 2.4 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.1 0.3 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244) regulation of connective tissue replacement(GO:1905203)
0.1 0.7 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.1 0.4 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.1 0.3 GO:0044830 modulation by host of viral RNA genome replication(GO:0044830)
0.1 0.4 GO:0009235 cobalamin metabolic process(GO:0009235)
0.1 0.6 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.1 3.0 GO:0006805 xenobiotic metabolic process(GO:0006805)
0.1 0.8 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.1 0.4 GO:0036112 medium-chain fatty-acyl-CoA metabolic process(GO:0036112)
0.1 0.5 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.1 2.7 GO:0072698 protein localization to microtubule cytoskeleton(GO:0072698)
0.1 1.2 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.1 0.3 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.1 GO:0015793 glycerol transport(GO:0015793)
0.0 0.3 GO:0045607 regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.0 1.7 GO:0010718 positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.0 0.7 GO:0007608 sensory perception of smell(GO:0007608)
0.0 1.3 GO:0006414 translational elongation(GO:0006414)
0.0 0.4 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0 0.3 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.0 0.7 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.0 0.3 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.0 0.2 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.3 GO:0033194 response to hydroperoxide(GO:0033194)
0.0 0.2 GO:0043968 histone H2A acetylation(GO:0043968)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.5 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.6 2.2 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.4 3.1 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.4 1.7 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.3 1.0 GO:0030690 Noc1p-Noc2p complex(GO:0030690)
0.3 0.8 GO:1990730 VCP-NSFL1C complex(GO:1990730)
0.1 2.7 GO:0097431 mitotic spindle pole(GO:0097431)
0.1 2.8 GO:0016580 Sin3 complex(GO:0016580)
0.1 0.7 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.1 0.6 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.1 1.6 GO:0031528 microvillus membrane(GO:0031528)
0.1 1.6 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 1.1 GO:0010369 chromocenter(GO:0010369)
0.1 0.3 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.4 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.9 GO:0032156 septin cytoskeleton(GO:0032156)
0.0 0.3 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.4 GO:0071439 clathrin complex(GO:0071439)
0.0 4.4 GO:0005814 centriole(GO:0005814)
0.0 2.7 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 1.4 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.5 GO:0033655 host cell cytoplasm(GO:0030430) host cell cytoplasm part(GO:0033655)
0.0 1.2 GO:0043034 costamere(GO:0043034)
0.0 1.8 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 2.4 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 1.2 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.3 GO:0031143 pseudopodium(GO:0031143)
0.0 5.5 GO:0005874 microtubule(GO:0005874)
0.0 0.9 GO:0036126 sperm flagellum(GO:0036126)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.5 GO:0034190 apolipoprotein receptor binding(GO:0034190)
1.0 3.1 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.9 2.8 GO:0035939 microsatellite binding(GO:0035939)
0.5 2.0 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733)
0.4 1.4 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
0.3 1.3 GO:0036468 aromatic-L-amino-acid decarboxylase activity(GO:0004058) L-dopa decarboxylase activity(GO:0036468)
0.3 0.8 GO:0036470 tyrosine 3-monooxygenase activator activity(GO:0036470) L-dopa decarboxylase activator activity(GO:0036478)
0.3 1.0 GO:0035877 death effector domain binding(GO:0035877)
0.2 1.2 GO:0032767 copper-dependent protein binding(GO:0032767)
0.2 0.7 GO:0004774 succinate-CoA ligase activity(GO:0004774)
0.2 1.0 GO:0015254 glycerol channel activity(GO:0015254)
0.2 5.8 GO:0017147 Wnt-protein binding(GO:0017147)
0.2 2.2 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1 0.4 GO:0003996 acyl-CoA ligase activity(GO:0003996)
0.1 2.0 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.1 0.7 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 0.3 GO:0048019 receptor antagonist activity(GO:0048019)
0.1 0.3 GO:0015232 heme transporter activity(GO:0015232)
0.1 1.4 GO:0005355 glucose transmembrane transporter activity(GO:0005355)
0.1 1.6 GO:0008143 poly(A) binding(GO:0008143) poly(U) RNA binding(GO:0008266)
0.1 2.5 GO:0030371 translation repressor activity(GO:0030371)
0.1 0.9 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 1.0 GO:0070402 NADPH binding(GO:0070402)
0.1 0.3 GO:0034235 GPI anchor binding(GO:0034235)
0.1 1.4 GO:0034185 apolipoprotein binding(GO:0034185)
0.1 0.8 GO:0005522 profilin binding(GO:0005522)
0.1 0.5 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.1 0.4 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.0 0.3 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 2.7 GO:0019894 kinesin binding(GO:0019894)
0.0 0.6 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.5 GO:0005537 mannose binding(GO:0005537)
0.0 0.5 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.7 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0 1.9 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 1.7 GO:0016209 antioxidant activity(GO:0016209)
0.0 0.4 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 1.3 GO:0030295 protein kinase activator activity(GO:0030295)
0.0 0.6 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 0.7 GO:0016860 intramolecular oxidoreductase activity(GO:0016860)
0.0 0.3 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 6.2 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 1.0 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1 4.0 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 2.2 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 0.5 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 2.5 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 1.1 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.3 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.7 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.6 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.4 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.4 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.8 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 1.0 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 1.3 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 1.0 REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.1 3.1 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.1 2.0 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.1 0.5 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.1 2.0 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 0.7 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 3.4 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.8 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.5 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.7 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 1.8 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.0 0.6 REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.3 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions