Motif ID: Gmeb2
Z-value: 0.739

Transcription factors associated with Gmeb2:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Gmeb2 | ENSMUSG00000038705.7 | Gmeb2 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Gmeb2 | mm10_v2_chr2_-_181288016_181288041 | 0.34 | 3.1e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 2.6 | GO:2001106 | regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106) |
0.6 | 2.5 | GO:0071475 | cellular hyperosmotic salinity response(GO:0071475) |
0.5 | 1.4 | GO:1901079 | positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738) positive regulation of relaxation of muscle(GO:1901079) |
0.4 | 1.3 | GO:0071579 | regulation of zinc ion transport(GO:0071579) |
0.4 | 1.1 | GO:0006592 | ornithine biosynthetic process(GO:0006592) |
0.4 | 1.1 | GO:0031554 | regulation of DNA-templated transcription, termination(GO:0031554) |
0.3 | 0.9 | GO:0042939 | glutathione transport(GO:0034635) oligopeptide transmembrane transport(GO:0035672) xenobiotic transport(GO:0042908) tripeptide transport(GO:0042939) |
0.3 | 0.8 | GO:1904211 | membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211) |
0.2 | 1.8 | GO:2000301 | negative regulation of synaptic vesicle exocytosis(GO:2000301) |
0.2 | 0.8 | GO:0018307 | tRNA wobble position uridine thiolation(GO:0002143) enzyme active site formation(GO:0018307) |
0.2 | 3.6 | GO:0010225 | response to UV-C(GO:0010225) |
0.2 | 0.8 | GO:0033540 | fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540) |
0.2 | 0.6 | GO:1902527 | positive regulation of protein monoubiquitination(GO:1902527) |
0.2 | 3.8 | GO:0046033 | AMP metabolic process(GO:0046033) |
0.2 | 0.9 | GO:0045347 | negative regulation of MHC class II biosynthetic process(GO:0045347) |
0.2 | 1.8 | GO:0071763 | nuclear membrane organization(GO:0071763) |
0.2 | 1.5 | GO:0099590 | neurotransmitter receptor internalization(GO:0099590) |
0.2 | 0.6 | GO:0042796 | snRNA transcription from RNA polymerase III promoter(GO:0042796) |
0.2 | 0.6 | GO:0006014 | D-ribose metabolic process(GO:0006014) |
0.2 | 0.5 | GO:0050975 | sensory perception of touch(GO:0050975) |
0.2 | 0.9 | GO:0097473 | cellular response to light intensity(GO:0071484) cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473) |
0.1 | 0.4 | GO:1904569 | regulation of selenocysteine incorporation(GO:1904569) |
0.1 | 1.0 | GO:0006621 | protein retention in ER lumen(GO:0006621) |
0.1 | 0.5 | GO:0030202 | heparin metabolic process(GO:0030202) |
0.1 | 0.7 | GO:0050861 | positive regulation of B cell receptor signaling pathway(GO:0050861) |
0.1 | 0.8 | GO:0045654 | positive regulation of megakaryocyte differentiation(GO:0045654) |
0.1 | 0.8 | GO:0019348 | dolichol metabolic process(GO:0019348) |
0.1 | 0.4 | GO:1902626 | assembly of large subunit precursor of preribosome(GO:1902626) |
0.1 | 0.4 | GO:1902340 | telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340) |
0.1 | 0.4 | GO:2000987 | positive regulation of fear response(GO:1903367) positive regulation of behavioral fear response(GO:2000987) |
0.1 | 0.3 | GO:0090526 | regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526) |
0.1 | 0.5 | GO:0072396 | response to cell cycle checkpoint signaling(GO:0072396) response to DNA integrity checkpoint signaling(GO:0072402) response to DNA damage checkpoint signaling(GO:0072423) |
0.1 | 0.3 | GO:0061739 | protein lipidation involved in autophagosome assembly(GO:0061739) |
0.1 | 1.3 | GO:0070986 | left/right axis specification(GO:0070986) |
0.1 | 0.8 | GO:0070475 | rRNA base methylation(GO:0070475) |
0.1 | 0.7 | GO:1902570 | protein localization to nucleolus(GO:1902570) |
0.1 | 0.7 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
0.1 | 0.2 | GO:0035574 | histone H4-K20 demethylation(GO:0035574) |
0.1 | 0.3 | GO:1903564 | regulation of protein localization to cilium(GO:1903564) |
0.1 | 0.6 | GO:2000786 | positive regulation of autophagosome assembly(GO:2000786) |
0.1 | 0.3 | GO:0018125 | peptidyl-cysteine methylation(GO:0018125) |
0.1 | 2.3 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
0.1 | 0.9 | GO:0016322 | neuron remodeling(GO:0016322) |
0.1 | 0.1 | GO:0045346 | regulation of MHC class II biosynthetic process(GO:0045346) |
0.1 | 0.1 | GO:1902256 | apoptotic process involved in outflow tract morphogenesis(GO:0003275) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256) |
0.1 | 0.3 | GO:0050847 | progesterone receptor signaling pathway(GO:0050847) |
0.0 | 0.5 | GO:0070234 | positive regulation of T cell apoptotic process(GO:0070234) |
0.0 | 0.2 | GO:0071787 | endoplasmic reticulum tubular network assembly(GO:0071787) |
0.0 | 0.1 | GO:0002447 | eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) eosinophil degranulation(GO:0043308) regulation of eosinophil activation(GO:1902566) |
0.0 | 0.9 | GO:0047497 | establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497) |
0.0 | 0.9 | GO:2000300 | regulation of synaptic vesicle exocytosis(GO:2000300) |
0.0 | 2.6 | GO:0045454 | cell redox homeostasis(GO:0045454) |
0.0 | 0.7 | GO:0043968 | histone H2A acetylation(GO:0043968) |
0.0 | 0.5 | GO:0033234 | negative regulation of protein sumoylation(GO:0033234) |
0.0 | 0.1 | GO:0009106 | lipoate metabolic process(GO:0009106) |
0.0 | 0.6 | GO:0071549 | cellular response to dexamethasone stimulus(GO:0071549) |
0.0 | 0.5 | GO:2001014 | regulation of skeletal muscle cell differentiation(GO:2001014) |
0.0 | 0.2 | GO:0006983 | ER overload response(GO:0006983) |
0.0 | 0.6 | GO:1902043 | positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043) |
0.0 | 0.2 | GO:0030206 | chondroitin sulfate biosynthetic process(GO:0030206) |
0.0 | 0.3 | GO:0090435 | protein localization to nuclear envelope(GO:0090435) |
0.0 | 0.4 | GO:0016558 | protein import into peroxisome matrix(GO:0016558) |
0.0 | 0.5 | GO:0051457 | maintenance of protein location in nucleus(GO:0051457) |
0.0 | 0.6 | GO:0036075 | endochondral ossification(GO:0001958) replacement ossification(GO:0036075) |
0.0 | 0.1 | GO:0032929 | negative regulation of superoxide anion generation(GO:0032929) negative regulation of amyloid precursor protein biosynthetic process(GO:0042985) |
0.0 | 0.1 | GO:0000972 | transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972) |
0.0 | 0.1 | GO:0014842 | regulation of skeletal muscle satellite cell proliferation(GO:0014842) |
0.0 | 0.6 | GO:0046329 | negative regulation of JNK cascade(GO:0046329) |
0.0 | 0.3 | GO:0007205 | protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205) |
0.0 | 0.1 | GO:0015692 | vanadium ion transport(GO:0015676) lead ion transport(GO:0015692) |
0.0 | 0.8 | GO:0051865 | protein autoubiquitination(GO:0051865) |
0.0 | 0.1 | GO:0061734 | parkin-mediated mitophagy in response to mitochondrial depolarization(GO:0061734) |
0.0 | 1.6 | GO:0002244 | hematopoietic progenitor cell differentiation(GO:0002244) |
0.0 | 0.2 | GO:0070816 | phosphorylation of RNA polymerase II C-terminal domain(GO:0070816) |
0.0 | 0.3 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 2.5 | GO:0043564 | Ku70:Ku80 complex(GO:0043564) |
0.3 | 1.4 | GO:0042583 | chromaffin granule(GO:0042583) |
0.2 | 0.8 | GO:0033185 | dolichol-phosphate-mannose synthase complex(GO:0033185) |
0.1 | 0.7 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
0.1 | 1.0 | GO:0000836 | ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836) |
0.1 | 0.4 | GO:0032280 | symmetric synapse(GO:0032280) |
0.1 | 0.8 | GO:0044322 | endoplasmic reticulum quality control compartment(GO:0044322) |
0.1 | 0.4 | GO:1990415 | Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429) |
0.1 | 0.5 | GO:0030893 | meiotic cohesin complex(GO:0030893) |
0.1 | 0.3 | GO:0070381 | endosome to plasma membrane transport vesicle(GO:0070381) |
0.1 | 1.3 | GO:0097228 | sperm principal piece(GO:0097228) |
0.1 | 0.4 | GO:0072357 | PTW/PP1 phosphatase complex(GO:0072357) |
0.1 | 0.9 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
0.1 | 2.4 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
0.0 | 2.3 | GO:0060170 | ciliary membrane(GO:0060170) |
0.0 | 0.7 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
0.0 | 0.6 | GO:0030127 | COPII vesicle coat(GO:0030127) |
0.0 | 0.6 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
0.0 | 1.5 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
0.0 | 1.7 | GO:0031901 | early endosome membrane(GO:0031901) |
0.0 | 0.2 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
0.0 | 0.3 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
0.0 | 0.5 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
0.0 | 0.2 | GO:0008024 | cyclin/CDK positive transcription elongation factor complex(GO:0008024) |
0.0 | 0.5 | GO:0005689 | U12-type spliceosomal complex(GO:0005689) |
0.0 | 0.1 | GO:0000322 | storage vacuole(GO:0000322) |
0.0 | 0.8 | GO:1990391 | DNA repair complex(GO:1990391) |
0.0 | 0.0 | GO:0005584 | collagen type I trimer(GO:0005584) |
0.0 | 0.2 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
0.0 | 0.1 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
0.0 | 0.1 | GO:0070826 | paraferritin complex(GO:0070826) |
0.0 | 0.4 | GO:0000788 | nuclear nucleosome(GO:0000788) |
0.0 | 0.2 | GO:0000124 | SAGA complex(GO:0000124) |
0.0 | 0.8 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.3 | 3.8 | GO:0046899 | nucleoside triphosphate adenylate kinase activity(GO:0046899) |
0.8 | 2.3 | GO:0004994 | somatostatin receptor activity(GO:0004994) |
0.4 | 1.1 | GO:0017084 | glutamate 5-kinase activity(GO:0004349) glutamate-5-semialdehyde dehydrogenase activity(GO:0004350) delta1-pyrroline-5-carboxylate synthetase activity(GO:0017084) amino acid kinase activity(GO:0019202) |
0.3 | 0.9 | GO:0035673 | oligopeptide transmembrane transporter activity(GO:0035673) sphingolipid transporter activity(GO:0046624) |
0.3 | 1.7 | GO:0042731 | PH domain binding(GO:0042731) |
0.3 | 3.1 | GO:0003691 | double-stranded telomeric DNA binding(GO:0003691) |
0.2 | 0.8 | GO:0004582 | dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582) |
0.2 | 0.6 | GO:0016309 | 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309) |
0.2 | 0.8 | GO:0004792 | thiosulfate sulfurtransferase activity(GO:0004792) |
0.2 | 0.8 | GO:0016434 | rRNA (cytosine) methyltransferase activity(GO:0016434) |
0.1 | 3.6 | GO:0097602 | cullin family protein binding(GO:0097602) |
0.1 | 0.8 | GO:0016401 | palmitoyl-CoA oxidase activity(GO:0016401) |
0.1 | 0.5 | GO:0036033 | mediator complex binding(GO:0036033) |
0.1 | 0.3 | GO:1990955 | G-rich single-stranded DNA binding(GO:1990955) |
0.1 | 0.3 | GO:0019153 | protein-disulfide reductase (glutathione) activity(GO:0019153) |
0.1 | 0.2 | GO:0097677 | STAT family protein binding(GO:0097677) |
0.1 | 0.8 | GO:0009008 | DNA-methyltransferase activity(GO:0009008) |
0.1 | 1.3 | GO:1990226 | histone methyltransferase binding(GO:1990226) |
0.1 | 0.5 | GO:0044547 | DNA topoisomerase binding(GO:0044547) |
0.1 | 1.8 | GO:0005521 | lamin binding(GO:0005521) |
0.1 | 0.9 | GO:0070008 | serine-type exopeptidase activity(GO:0070008) |
0.1 | 2.0 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
0.1 | 1.8 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
0.1 | 0.6 | GO:0001162 | RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162) |
0.1 | 0.2 | GO:0050510 | N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510) |
0.1 | 0.2 | GO:0035575 | histone demethylase activity (H4-K20 specific)(GO:0035575) |
0.1 | 0.4 | GO:0035368 | selenocysteine insertion sequence binding(GO:0035368) |
0.1 | 0.4 | GO:0001515 | opioid peptide activity(GO:0001515) |
0.1 | 0.6 | GO:0016861 | intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861) |
0.1 | 0.6 | GO:0008526 | phosphatidylinositol transporter activity(GO:0008526) |
0.0 | 0.6 | GO:0001054 | RNA polymerase I activity(GO:0001054) |
0.0 | 0.7 | GO:0031489 | myosin V binding(GO:0031489) |
0.0 | 0.1 | GO:0016230 | sphingomyelin phosphodiesterase activator activity(GO:0016230) |
0.0 | 0.6 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
0.0 | 0.3 | GO:0010314 | phosphatidylinositol-5-phosphate binding(GO:0010314) |
0.0 | 0.5 | GO:0034483 | heparan sulfate sulfotransferase activity(GO:0034483) |
0.0 | 0.1 | GO:0017150 | tRNA dihydrouridine synthase activity(GO:0017150) |
0.0 | 0.1 | GO:0016979 | lipoate-protein ligase activity(GO:0016979) |
0.0 | 1.3 | GO:0035064 | methylated histone binding(GO:0035064) |
0.0 | 1.2 | GO:0030276 | clathrin binding(GO:0030276) |
0.0 | 0.7 | GO:0016278 | lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279) |
0.0 | 0.1 | GO:0008301 | DNA binding, bending(GO:0008301) |
0.0 | 0.3 | GO:0015035 | protein disulfide oxidoreductase activity(GO:0015035) |
0.0 | 0.5 | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity(GO:0003755) |
0.0 | 0.1 | GO:0015086 | cadmium ion transmembrane transporter activity(GO:0015086) lead ion transmembrane transporter activity(GO:0015094) vanadium ion transmembrane transporter activity(GO:0015100) ferrous iron uptake transmembrane transporter activity(GO:0015639) |
0.0 | 0.9 | GO:0005080 | protein kinase C binding(GO:0005080) |
0.0 | 0.1 | GO:0004652 | polynucleotide adenylyltransferase activity(GO:0004652) |
0.0 | 0.9 | GO:0097110 | scaffold protein binding(GO:0097110) |
0.0 | 0.2 | GO:0034236 | protein kinase A catalytic subunit binding(GO:0034236) |
0.0 | 0.8 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
0.0 | 0.5 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 2.5 | PID_DNA_PK_PATHWAY | DNA-PK pathway in nonhomologous end joining |
0.1 | 1.8 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
0.1 | 1.1 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
0.1 | 0.9 | PID_S1P_S1P1_PATHWAY | S1P1 pathway |
0.0 | 1.7 | PID_EPHA_FWDPATHWAY | EPHA forward signaling |
0.0 | 1.2 | ST_INTERLEUKIN_4_PATHWAY | Interleukin 4 (IL-4) Pathway |
0.0 | 3.4 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
0.0 | 0.5 | PID_HIF1A_PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
0.0 | 0.3 | PID_RANBP2_PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
0.0 | 0.5 | PID_ATM_PATHWAY | ATM pathway |
0.0 | 0.8 | PID_HEDGEHOG_GLI_PATHWAY | Hedgehog signaling events mediated by Gli proteins |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 2.5 | REACTOME_INTEGRATION_OF_PROVIRUS | Genes involved in Integration of provirus |
0.1 | 1.8 | REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING | Genes involved in Spry regulation of FGF signaling |
0.1 | 1.5 | REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
0.1 | 0.9 | REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
0.1 | 0.9 | REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
0.0 | 0.8 | REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
0.0 | 0.5 | REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
0.0 | 1.1 | REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
0.0 | 0.7 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |
0.0 | 0.8 | REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
0.0 | 0.9 | REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT | Genes involved in ABC-family proteins mediated transport |
0.0 | 2.7 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
0.0 | 1.1 | REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
0.0 | 0.6 | REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter |
0.0 | 0.6 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
0.0 | 0.8 | REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
0.0 | 0.3 | REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
0.0 | 0.4 | REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
0.0 | 0.5 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
0.0 | 0.1 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
0.0 | 0.3 | REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING | Genes involved in Growth hormone receptor signaling |