Motif ID: Hoxa4

Z-value: 0.864


Transcription factors associated with Hoxa4:

Gene SymbolEntrez IDGene Name
Hoxa4 ENSMUSG00000000942.10 Hoxa4



Activity profile for motif Hoxa4.

activity profile for motif Hoxa4


Sorted Z-values histogram for motif Hoxa4

Sorted Z-values for motif Hoxa4



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_71528657 12.830 ENSMUST00000126400.1
Dlx1
distal-less homeobox 1
chr4_+_144892813 4.101 ENSMUST00000105744.1
ENSMUST00000171001.1
Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr2_+_70563435 3.750 ENSMUST00000123330.1
Gad1
glutamate decarboxylase 1
chr7_-_19699008 3.732 ENSMUST00000174355.1
ENSMUST00000172983.1
ENSMUST00000174710.1
ENSMUST00000167646.2
ENSMUST00000003066.9
ENSMUST00000174064.1
Apoe





apolipoprotein E





chr4_+_144893077 3.289 ENSMUST00000154208.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr4_+_144893127 2.968 ENSMUST00000142808.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr18_-_31949571 2.863 ENSMUST00000064016.5
Gpr17
G protein-coupled receptor 17
chr12_+_38780284 2.555 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
Etv1


ets variant gene 1


chr2_-_77519565 2.415 ENSMUST00000111830.2
Zfp385b
zinc finger protein 385B
chr6_+_8949670 2.393 ENSMUST00000060369.3
Nxph1
neurexophilin 1
chr1_-_190170671 2.178 ENSMUST00000175916.1
Prox1
prospero-related homeobox 1
chr17_+_39846958 2.123 ENSMUST00000182010.1
Gm26924
predicted gene, 26924
chr3_-_80802789 2.084 ENSMUST00000107745.1
ENSMUST00000075316.4
Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr12_+_38780817 2.062 ENSMUST00000160856.1
Etv1
ets variant gene 1
chr3_+_5218546 2.060 ENSMUST00000026284.6
Zfhx4
zinc finger homeodomain 4
chr2_+_170731807 1.774 ENSMUST00000029075.4
Dok5
docking protein 5
chr3_+_86070915 1.772 ENSMUST00000182666.1
Sh3d19
SH3 domain protein D19
chr3_+_5218516 1.662 ENSMUST00000175866.1
Zfhx4
zinc finger homeodomain 4
chr19_-_28967794 1.637 ENSMUST00000162110.1
4430402I18Rik
RIKEN cDNA 4430402I18 gene
chr3_+_5218589 1.429 ENSMUST00000177488.1
Zfhx4
zinc finger homeodomain 4
chr12_+_38781093 1.341 ENSMUST00000161513.1
Etv1
ets variant gene 1
chrX_+_136822781 1.338 ENSMUST00000113085.1
Plp1
proteolipid protein (myelin) 1
chr12_-_56535047 1.334 ENSMUST00000178477.2
Nkx2-1
NK2 homeobox 1
chr15_-_99820072 1.322 ENSMUST00000109024.2
Lima1
LIM domain and actin binding 1
chr1_+_165788681 1.270 ENSMUST00000161971.1
ENSMUST00000178336.1
ENSMUST00000005907.5
ENSMUST00000027849.4
Cd247



CD247 antigen



chrX_+_56454871 1.186 ENSMUST00000039374.2
ENSMUST00000101553.2
Ddx26b

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B

chrX_+_136822671 1.178 ENSMUST00000033800.6
Plp1
proteolipid protein (myelin) 1
chr17_-_84187939 1.154 ENSMUST00000060366.6
Zfp36l2
zinc finger protein 36, C3H type-like 2
chr10_+_84756055 1.153 ENSMUST00000060397.6
Rfx4
regulatory factor X, 4 (influences HLA class II expression)
chr1_+_165788746 1.138 ENSMUST00000161559.2
Cd247
CD247 antigen
chr7_+_144838590 1.137 ENSMUST00000105898.1
Fgf3
fibroblast growth factor 3
chr15_+_32920723 1.086 ENSMUST00000022871.5
Sdc2
syndecan 2
chr5_-_111761697 1.085 ENSMUST00000129146.1
ENSMUST00000137398.1
ENSMUST00000129065.1
E130006D01Rik


RIKEN cDNA E130006D01 gene


chr18_+_76059458 1.082 ENSMUST00000167921.1
Zbtb7c
zinc finger and BTB domain containing 7C
chr5_+_64812336 1.080 ENSMUST00000166409.1
Klf3
Kruppel-like factor 3 (basic)
chr16_-_64786321 1.052 ENSMUST00000052588.4
Zfp654
zinc finger protein 654
chr11_+_29463735 1.037 ENSMUST00000155854.1
Ccdc88a
coiled coil domain containing 88A
chr10_-_93311073 1.008 ENSMUST00000008542.5
Elk3
ELK3, member of ETS oncogene family
chr1_-_158356258 0.996 ENSMUST00000004133.8
Brinp2
bone morphogenic protein/retinoic acid inducible neural-specific 2
chr3_-_146682410 0.989 ENSMUST00000124931.1
ENSMUST00000147113.1
Samd13

sterile alpha motif domain containing 13

chr5_+_115908644 0.972 ENSMUST00000141101.1
Cit
citron
chr2_+_109917639 0.948 ENSMUST00000046548.7
ENSMUST00000111037.2
Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr15_-_56694525 0.923 ENSMUST00000050544.7
Has2
hyaluronan synthase 2
chr2_-_72986716 0.913 ENSMUST00000112062.1
Gm11084
predicted gene 11084
chr17_-_26886175 0.887 ENSMUST00000108741.2
Gm17382
predicted gene, 17382
chr9_-_42399915 0.880 ENSMUST00000042190.7
Tecta
tectorin alpha
chr5_-_146220901 0.877 ENSMUST00000169407.2
ENSMUST00000161331.1
ENSMUST00000159074.2
ENSMUST00000067837.3
Rnf6



ring finger protein (C3H2C3 type) 6



chr12_+_38783503 0.854 ENSMUST00000159334.1
Etv1
ets variant gene 1
chr1_-_165934900 0.844 ENSMUST00000069609.5
ENSMUST00000111427.2
ENSMUST00000111426.4
Pou2f1


POU domain, class 2, transcription factor 1


chr15_+_62037986 0.841 ENSMUST00000182956.1
ENSMUST00000182075.1
ENSMUST00000180432.2
ENSMUST00000181416.2
ENSMUST00000181657.2
Pvt1




plasmacytoma variant translocation 1




chr9_-_50555170 0.838 ENSMUST00000119103.1
Bco2
beta-carotene oxygenase 2
chr12_-_99883429 0.824 ENSMUST00000046485.3
Efcab11
EF-hand calcium binding domain 11
chrX_-_38252398 0.807 ENSMUST00000089056.3
ENSMUST00000089054.4
ENSMUST00000066498.7
Tmem255a


transmembrane protein 255A


chr16_-_76373827 0.802 ENSMUST00000121927.1
Nrip1
nuclear receptor interacting protein 1
chr12_+_38783455 0.790 ENSMUST00000161980.1
ENSMUST00000160701.1
Etv1

ets variant gene 1

chr14_-_79771305 0.788 ENSMUST00000039568.5
Pcdh8
protocadherin 8
chr13_-_107890059 0.780 ENSMUST00000105097.2
Zswim6
zinc finger SWIM-type containing 6
chr12_+_52516077 0.775 ENSMUST00000110725.1
Arhgap5
Rho GTPase activating protein 5
chr10_-_128525859 0.760 ENSMUST00000026427.6
Esyt1
extended synaptotagmin-like protein 1
chr13_+_94875600 0.752 ENSMUST00000022195.10
Otp
orthopedia homolog (Drosophila)
chr3_+_88965812 0.709 ENSMUST00000090933.4
Ash1l
ash1 (absent, small, or homeotic)-like (Drosophila)
chr1_-_163313661 0.699 ENSMUST00000174397.1
ENSMUST00000075805.6
ENSMUST00000027878.7
Prrx1


paired related homeobox 1


chr6_+_56832059 0.694 ENSMUST00000031795.7
Fkbp9
FK506 binding protein 9
chr5_+_137030275 0.685 ENSMUST00000041543.8
Vgf
VGF nerve growth factor inducible
chr17_+_45734506 0.677 ENSMUST00000180558.1
F630040K05Rik
RIKEN cDNA F630040K05 gene
chr1_-_152766281 0.676 ENSMUST00000111859.1
ENSMUST00000148865.1
Rgl1

ral guanine nucleotide dissociation stimulator,-like 1

chr2_+_4400958 0.665 ENSMUST00000075767.7
Frmd4a
FERM domain containing 4A
chr7_+_30121915 0.661 ENSMUST00000098596.3
ENSMUST00000153792.1
Zfp382

zinc finger protein 382

chr7_+_112742025 0.638 ENSMUST00000164363.1
Tead1
TEA domain family member 1
chr13_-_117025505 0.638 ENSMUST00000022239.6
Parp8
poly (ADP-ribose) polymerase family, member 8
chrX_+_66653003 0.637 ENSMUST00000036043.4
Slitrk2
SLIT and NTRK-like family, member 2
chr5_-_137314175 0.634 ENSMUST00000024119.9
Trip6
thyroid hormone receptor interactor 6
chr14_-_30353468 0.632 ENSMUST00000112249.1
Cacna1d
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr11_-_30986326 0.621 ENSMUST00000020553.4
ENSMUST00000101394.4
Chac2

ChaC, cation transport regulator 2

chr2_-_116065798 0.621 ENSMUST00000110907.1
ENSMUST00000110908.2
Meis2

Meis homeobox 2

chr1_-_180193475 0.614 ENSMUST00000160482.1
ENSMUST00000170472.1
Adck3

aarF domain containing kinase 3

chr4_+_11579647 0.604 ENSMUST00000180239.1
Fsbp
fibrinogen silencer binding protein
chr5_+_17574726 0.603 ENSMUST00000169603.1
Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr1_-_5070281 0.602 ENSMUST00000147158.1
ENSMUST00000118000.1
Rgs20

regulator of G-protein signaling 20

chr12_+_65075582 0.602 ENSMUST00000058889.4
Fancm
Fanconi anemia, complementation group M
chr12_+_109546409 0.582 ENSMUST00000143847.1
Meg3
maternally expressed 3
chr5_-_122002340 0.563 ENSMUST00000134326.1
Cux2
cut-like homeobox 2
chr9_+_75775355 0.557 ENSMUST00000012281.7
Bmp5
bone morphogenetic protein 5
chr2_-_65529275 0.545 ENSMUST00000126837.1
Scn3a
sodium channel, voltage-gated, type III, alpha
chr7_+_34251038 0.544 ENSMUST00000105172.1
Gm6096
predicted gene 6096
chr3_+_116562965 0.537 ENSMUST00000029573.5
Lrrc39
leucine rich repeat containing 39
chr13_+_23555023 0.519 ENSMUST00000045301.6
Hist1h1d
histone cluster 1, H1d
chr9_+_72274966 0.519 ENSMUST00000183410.1
Zfp280d
zinc finger protein 280D
chr6_+_5390387 0.514 ENSMUST00000183358.1
Asb4
ankyrin repeat and SOCS box-containing 4
chr12_-_86079019 0.513 ENSMUST00000003687.6
Tgfb3
transforming growth factor, beta 3
chr1_-_152766323 0.511 ENSMUST00000111857.1
Rgl1
ral guanine nucleotide dissociation stimulator,-like 1
chr12_+_109546333 0.506 ENSMUST00000166636.2
Meg3
maternally expressed 3
chr14_+_46832127 0.499 ENSMUST00000068532.8
Cgrrf1
cell growth regulator with ring finger domain 1
chr2_-_116065047 0.495 ENSMUST00000028639.6
ENSMUST00000102538.4
Meis2

Meis homeobox 2

chr11_+_57011945 0.494 ENSMUST00000094179.4
Gria1
glutamate receptor, ionotropic, AMPA1 (alpha 1)
chr5_+_76809964 0.482 ENSMUST00000120818.1
C530008M17Rik
RIKEN cDNA C530008M17 gene
chr19_+_55894508 0.467 ENSMUST00000142291.1
Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr15_-_77956658 0.452 ENSMUST00000117725.1
ENSMUST00000016696.6
Foxred2

FAD-dependent oxidoreductase domain containing 2

chr12_+_29528382 0.449 ENSMUST00000049784.9
Myt1l
myelin transcription factor 1-like
chr6_+_124916863 0.433 ENSMUST00000069553.2
A230083G16Rik
RIKEN cDNA A230083G16 gene
chr12_+_91400990 0.432 ENSMUST00000021346.7
ENSMUST00000021343.6
Tshr

thyroid stimulating hormone receptor

chr18_-_37178493 0.432 ENSMUST00000181887.1
ENSMUST00000180516.1
Gm10544

predicted gene 10544

chr19_-_42752710 0.427 ENSMUST00000076505.3
Pyroxd2
pyridine nucleotide-disulphide oxidoreductase domain 2
chr11_+_57011798 0.418 ENSMUST00000036315.9
Gria1
glutamate receptor, ionotropic, AMPA1 (alpha 1)
chr1_+_93478964 0.413 ENSMUST00000027495.8
ENSMUST00000136182.1
ENSMUST00000131175.2
ENSMUST00000179353.1
ENSMUST00000172165.1
ENSMUST00000153826.1
ENSMUST00000129211.1
ENSMUST00000168776.1
ENSMUST00000112912.1
Sept2








septin 2








chr1_-_130729249 0.404 ENSMUST00000171479.1
Pfkfb2
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
chr15_+_18818895 0.402 ENSMUST00000166873.2
Cdh10
cadherin 10
chr7_+_64185459 0.399 ENSMUST00000177102.2
ENSMUST00000107519.1
ENSMUST00000137650.1
ENSMUST00000032737.5
ENSMUST00000107515.1
ENSMUST00000144996.1
Trpm1





transient receptor potential cation channel, subfamily M, member 1





chr13_+_38204928 0.392 ENSMUST00000091641.5
ENSMUST00000178564.1
Snrnp48

small nuclear ribonucleoprotein 48 (U11/U12)

chr10_+_53337686 0.386 ENSMUST00000046221.6
ENSMUST00000163319.1
Pln

phospholamban

chr15_-_37458523 0.386 ENSMUST00000116445.2
Ncald
neurocalcin delta
chr6_+_86527312 0.385 ENSMUST00000181928.1
1600020E01Rik
RIKEN cDNA 1600020E01 gene
chr17_-_43667015 0.383 ENSMUST00000024705.4
Slc25a27
solute carrier family 25, member 27
chr9_-_32541589 0.375 ENSMUST00000016231.7
Fli1
Friend leukemia integration 1
chr14_+_79515618 0.374 ENSMUST00000110835.1
Elf1
E74-like factor 1
chr18_-_79109391 0.369 ENSMUST00000025430.8
ENSMUST00000161465.2
Setbp1

SET binding protein 1

chr18_-_42579652 0.364 ENSMUST00000054738.3
Gpr151
G protein-coupled receptor 151
chr12_-_84361802 0.359 ENSMUST00000021659.1
ENSMUST00000065536.2
Fam161b

family with sequence similarity 161, member B

chr6_+_134981998 0.347 ENSMUST00000167323.1
Apold1
apolipoprotein L domain containing 1
chr3_-_122619442 0.343 ENSMUST00000162947.1
Fnbp1l
formin binding protein 1-like
chr17_-_71459300 0.337 ENSMUST00000183937.1
Gm4707
predicted gene 4707
chr9_-_29412204 0.337 ENSMUST00000115237.1
Ntm
neurotrimin
chr13_+_58807884 0.325 ENSMUST00000079828.5
Ntrk2
neurotrophic tyrosine kinase, receptor, type 2
chr15_-_37459327 0.324 ENSMUST00000119730.1
ENSMUST00000120746.1
Ncald

neurocalcin delta

chr1_+_132298606 0.321 ENSMUST00000046071.4
Klhdc8a
kelch domain containing 8A
chr16_+_4639941 0.320 ENSMUST00000038770.3
Vasn
vasorin
chr18_+_37489465 0.311 ENSMUST00000055949.2
Pcdhb18
protocadherin beta 18
chr2_+_83644435 0.309 ENSMUST00000081591.6
Zc3h15
zinc finger CCCH-type containing 15
chr4_+_138775735 0.305 ENSMUST00000030528.2
Pla2g2d
phospholipase A2, group IID
chr18_-_15063560 0.296 ENSMUST00000168989.1
Kctd1
potassium channel tetramerisation domain containing 1
chr8_+_4238733 0.285 ENSMUST00000110998.2
ENSMUST00000062686.4
Map2k7

mitogen-activated protein kinase kinase 7

chr9_-_110624361 0.274 ENSMUST00000035069.9
Nradd
neurotrophin receptor associated death domain
chr7_-_116031047 0.271 ENSMUST00000106612.1
Sox6
SRY-box containing gene 6
chr1_+_19208914 0.264 ENSMUST00000027059.4
Tfap2b
transcription factor AP-2 beta
chr5_-_122614445 0.256 ENSMUST00000127220.1
ENSMUST00000031426.7
Ift81

intraflagellar transport 81

chr1_+_178529113 0.244 ENSMUST00000161017.1
Kif26b
kinesin family member 26B
chr9_-_65885024 0.239 ENSMUST00000122410.1
ENSMUST00000117083.1
Trip4

thyroid hormone receptor interactor 4

chr3_-_88177671 0.236 ENSMUST00000181837.1
1700113A16Rik
RIKEN cDNA 1700113A16 gene
chr8_-_84937347 0.236 ENSMUST00000109741.2
ENSMUST00000119820.1
Mast1

microtubule associated serine/threonine kinase 1

chr10_+_128238034 0.233 ENSMUST00000105245.2
Timeless
timeless circadian clock 1
chr1_+_180101144 0.233 ENSMUST00000133890.1
Cdc42bpa
CDC42 binding protein kinase alpha
chr10_+_39612934 0.229 ENSMUST00000019987.6
Traf3ip2
TRAF3 interacting protein 2
chr8_+_4238815 0.219 ENSMUST00000003027.7
ENSMUST00000110999.1
Map2k7

mitogen-activated protein kinase kinase 7

chr4_+_130107556 0.210 ENSMUST00000030563.5
Pef1
penta-EF hand domain containing 1
chr9_-_49798729 0.207 ENSMUST00000166811.2
Ncam1
neural cell adhesion molecule 1
chr14_-_70642268 0.202 ENSMUST00000022697.5
Fgf17
fibroblast growth factor 17
chr12_+_84362029 0.201 ENSMUST00000110278.1
ENSMUST00000145522.1
Coq6

coenzyme Q6 homolog (yeast)

chr3_+_41564880 0.195 ENSMUST00000168086.1
Phf17
PHD finger protein 17
chr6_+_106769120 0.195 ENSMUST00000113247.1
ENSMUST00000113249.1
ENSMUST00000057578.9
ENSMUST00000113248.1
Trnt1



tRNA nucleotidyl transferase, CCA-adding, 1



chrX_+_140956892 0.193 ENSMUST00000112971.1
Atg4a
autophagy related 4A, cysteine peptidase
chr10_-_70655934 0.190 ENSMUST00000162144.1
ENSMUST00000162793.1
Phyhipl

phytanoyl-CoA hydroxylase interacting protein-like

chr4_+_119814495 0.188 ENSMUST00000106307.2
Hivep3
human immunodeficiency virus type I enhancer binding protein 3
chr3_-_103791537 0.177 ENSMUST00000118317.1
Hipk1
homeodomain interacting protein kinase 1
chr2_-_93849679 0.166 ENSMUST00000068513.4
ENSMUST00000041593.8
ENSMUST00000130077.1
Accs


1-aminocyclopropane-1-carboxylate synthase (non-functional)


chr14_+_116925379 0.155 ENSMUST00000088483.3
Gpc6
glypican 6
chr18_+_60963517 0.153 ENSMUST00000115295.2
ENSMUST00000039904.6
Camk2a

calcium/calmodulin-dependent protein kinase II alpha

chr9_-_49798905 0.150 ENSMUST00000114476.2
Ncam1
neural cell adhesion molecule 1
chr3_-_146781351 0.137 ENSMUST00000005164.7
Prkacb
protein kinase, cAMP dependent, catalytic, beta
chr4_-_62519885 0.136 ENSMUST00000107444.1
ENSMUST00000030090.3
Alad

aminolevulinate, delta-, dehydratase

chr3_+_95164306 0.130 ENSMUST00000107217.1
ENSMUST00000168321.1
Sema6c

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C

chr4_-_83486453 0.129 ENSMUST00000107214.2
ENSMUST00000107215.2
ENSMUST00000030207.8
Psip1


PC4 and SFRS1 interacting protein 1


chr10_-_127030789 0.128 ENSMUST00000120547.1
ENSMUST00000152054.1
Tsfm

Ts translation elongation factor, mitochondrial

chr10_+_87859062 0.117 ENSMUST00000095360.4
Igf1
insulin-like growth factor 1
chr9_-_55919605 0.116 ENSMUST00000037408.8
Scaper
S phase cyclin A-associated protein in the ER
chr3_+_134236483 0.112 ENSMUST00000181904.1
ENSMUST00000053048.9
Cxxc4

CXXC finger 4

chr19_-_38224096 0.110 ENSMUST00000067167.5
Fra10ac1
FRA10AC1 homolog (human)
chr18_+_37307445 0.104 ENSMUST00000056712.2
Pcdhb4
protocadherin beta 4
chr12_+_84361968 0.097 ENSMUST00000021661.6
Coq6
coenzyme Q6 homolog (yeast)
chr5_+_30814722 0.097 ENSMUST00000114724.1
Mapre3
microtubule-associated protein, RP/EB family, member 3
chr19_+_11965817 0.096 ENSMUST00000025590.9
Osbp
oxysterol binding protein
chr12_+_84996309 0.090 ENSMUST00000168977.1
ENSMUST00000021670.8
Ylpm1

YLP motif containing 1

chr1_-_74601345 0.086 ENSMUST00000136078.1
ENSMUST00000132081.1
ENSMUST00000113721.1
ENSMUST00000027357.5
Rnf25



ring finger protein 25



chr4_-_129378116 0.080 ENSMUST00000030610.2
Zbtb8a
zinc finger and BTB domain containing 8a
chr6_+_124304646 0.078 ENSMUST00000112541.2
ENSMUST00000032234.2
Cd163

CD163 antigen

chr12_+_84361636 0.075 ENSMUST00000110276.1
Coq6
coenzyme Q6 homolog (yeast)
chr8_+_106059562 0.075 ENSMUST00000109308.1
Nfatc3
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3
chr8_+_46986913 0.063 ENSMUST00000039840.7
ENSMUST00000119686.1
Enpp6

ectonucleotide pyrophosphatase/phosphodiesterase 6

chr8_+_47713266 0.056 ENSMUST00000180928.1
E030037K01Rik
RIKEN cDNA E030037K01 gene
chr2_-_163417092 0.051 ENSMUST00000127038.1
Oser1
oxidative stress responsive serine rich 1
chr7_-_45052865 0.051 ENSMUST00000057293.6
Prr12
proline rich 12
chr13_+_63015167 0.045 ENSMUST00000021911.8
2010111I01Rik
RIKEN cDNA 2010111I01 gene
chr3_+_68572245 0.044 ENSMUST00000170788.2
Schip1
schwannomin interacting protein 1
chr3_+_94837702 0.039 ENSMUST00000107266.1
ENSMUST00000042402.5
ENSMUST00000107269.1
Pogz


pogo transposable element with ZNF domain


chr8_-_67974567 0.032 ENSMUST00000098696.3
ENSMUST00000038959.9
ENSMUST00000093469.4
Psd3


pleckstrin and Sec7 domain containing 3


chr17_+_43667389 0.026 ENSMUST00000170988.1
Cyp39a1
cytochrome P450, family 39, subfamily a, polypeptide 1
chr18_+_37819543 0.024 ENSMUST00000055935.5
Pcdhga9
protocadherin gamma subfamily A, 9
chr10_-_127121125 0.024 ENSMUST00000164259.1
ENSMUST00000080975.4
Os9

amplified in osteosarcoma

chr3_+_94837533 0.020 ENSMUST00000107270.2
Pogz
pogo transposable element with ZNF domain
chr10_-_92162753 0.020 ENSMUST00000182197.1
Rmst
rhabdomyosarcoma 2 associated transcript (non-coding RNA)
chr13_+_63014934 0.017 ENSMUST00000091560.4
2010111I01Rik
RIKEN cDNA 2010111I01 gene
chr11_-_121673103 0.015 ENSMUST00000067399.7
ENSMUST00000062654.7
B3gntl1

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1

chr2_-_13271268 0.015 ENSMUST00000137670.1
ENSMUST00000114791.2
Rsu1

Ras suppressor protein 1

chr3_+_89459118 0.008 ENSMUST00000029564.5
Pmvk
phosphomevalonate kinase
chr17_+_91236787 0.004 ENSMUST00000057074.8
Gm6741
predicted gene 6741

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.3 12.8 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
1.2 3.7 GO:1903002 regulation of lipid transport across blood brain barrier(GO:1903000) positive regulation of lipid transport across blood brain barrier(GO:1903002)
0.9 10.0 GO:0042572 retinol metabolic process(GO:0042572)
0.7 2.2 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.7 7.9 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.5 3.8 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.4 1.3 GO:0021759 globus pallidus development(GO:0021759)
0.4 2.9 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.3 0.9 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.3 0.8 GO:0001543 ovarian follicle rupture(GO:0001543)
0.2 0.9 GO:1900623 positive regulation of keratinocyte proliferation(GO:0010838) regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.2 1.2 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.2 1.0 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.2 1.1 GO:0030916 otic vesicle formation(GO:0030916) semicircular canal morphogenesis(GO:0048752)
0.2 0.4 GO:0010288 response to lead ion(GO:0010288)
0.2 0.7 GO:0002674 negative regulation of acute inflammatory response(GO:0002674)
0.2 0.9 GO:0044314 protein K27-linked ubiquitination(GO:0044314)
0.2 0.5 GO:0003032 detection of oxygen(GO:0003032)
0.2 2.5 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.2 0.6 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.2 0.6 GO:0006751 glutathione catabolic process(GO:0006751)
0.1 1.2 GO:1904627 response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)
0.1 0.6 GO:0021502 neural fold elevation formation(GO:0021502)
0.1 0.8 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.1 0.8 GO:0042574 isoprenoid catabolic process(GO:0008300) retinal metabolic process(GO:0042574)
0.1 1.8 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.1 0.5 GO:0046684 response to pyrethroid(GO:0046684)
0.1 1.1 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.1 0.6 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.1 0.6 GO:0003350 pulmonary myocardium development(GO:0003350)
0.1 0.4 GO:0051562 negative regulation of mitochondrial calcium ion concentration(GO:0051562)
0.1 0.3 GO:0097274 urea homeostasis(GO:0097274)
0.1 1.8 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 0.2 GO:0072092 ureteric bud invasion(GO:0072092)
0.1 2.4 GO:0070207 protein homotrimerization(GO:0070207)
0.1 0.2 GO:1904975 response to bleomycin(GO:1904975) cellular response to bleomycin(GO:1904976)
0.1 0.5 GO:0016584 nucleosome positioning(GO:0016584)
0.1 2.2 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.1 0.4 GO:1904587 response to glycoprotein(GO:1904587)
0.1 0.2 GO:1902527 positive regulation of protein monoubiquitination(GO:1902527)
0.1 0.2 GO:0090646 mitochondrial RNA 3'-end processing(GO:0000965) mitochondrial tRNA processing(GO:0090646)
0.1 0.5 GO:0048625 myoblast fate commitment(GO:0048625)
0.1 0.7 GO:0048664 neuron fate determination(GO:0048664)
0.1 0.6 GO:0014883 transition between fast and slow fiber(GO:0014883)
0.1 0.6 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.1 1.0 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.1 0.8 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.1 0.7 GO:0043084 penile erection(GO:0043084)
0.1 0.5 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.0 0.5 GO:2000671 regulation of motor neuron apoptotic process(GO:2000671)
0.0 0.3 GO:0051775 response to redox state(GO:0051775)
0.0 1.1 GO:0008340 determination of adult lifespan(GO:0008340)
0.0 0.4 GO:0086023 adrenergic receptor signaling pathway involved in heart process(GO:0086023)
0.0 0.2 GO:0051697 protein delipidation(GO:0051697)
0.0 0.3 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.0 0.1 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.0 0.4 GO:0046548 retinal rod cell development(GO:0046548)
0.0 0.3 GO:1903301 positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301)
0.0 0.3 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0 0.9 GO:0007616 long-term memory(GO:0007616)
0.0 0.6 GO:0007614 short-term memory(GO:0007614)
0.0 0.2 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.0 0.1 GO:1903031 regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033)
0.0 2.6 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.0 0.4 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.4 GO:0006744 ubiquinone biosynthetic process(GO:0006744)
0.0 1.1 GO:0008542 visual learning(GO:0008542)
0.0 0.4 GO:0035855 megakaryocyte development(GO:0035855)
0.0 0.2 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.0 0.5 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 0.1 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.7 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.8 GO:0002053 positive regulation of mesenchymal cell proliferation(GO:0002053)
0.0 0.8 GO:2001222 regulation of neuron migration(GO:2001222)
0.0 0.1 GO:0071285 cellular response to lithium ion(GO:0071285)
0.0 0.1 GO:0019695 choline metabolic process(GO:0019695)
0.0 0.8 GO:0001756 somitogenesis(GO:0001756)
0.0 0.6 GO:0031529 ruffle organization(GO:0031529)
0.0 1.1 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)
0.0 0.7 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.0 1.3 GO:0007050 cell cycle arrest(GO:0007050)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.7 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.6 2.4 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.2 0.6 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.2 0.9 GO:0044308 axonal spine(GO:0044308)
0.1 2.1 GO:0032279 asymmetric synapse(GO:0032279)
0.1 0.5 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.1 3.5 GO:0060077 inhibitory synapse(GO:0060077)
0.1 0.4 GO:0005826 actomyosin contractile ring(GO:0005826)
0.1 0.6 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 0.6 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.1 0.5 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 0.2 GO:0099573 glutamatergic postsynaptic density(GO:0099573)
0.0 0.8 GO:0044232 organelle membrane contact site(GO:0044232)
0.0 0.5 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 1.8 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.4 GO:0051286 cell tip(GO:0051286)
0.0 0.3 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.4 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.8 GO:0032420 stereocilium(GO:0032420)
0.0 0.3 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.4 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.5 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 0.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.5 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.7 GO:0030667 secretory granule membrane(GO:0030667)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 10.4 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
1.2 3.7 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.5 3.8 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.4 3.0 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.3 2.5 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.3 0.9 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.3 1.0 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.2 1.2 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.2 2.0 GO:0050693 LBD domain binding(GO:0050693)
0.1 0.5 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 0.6 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.1 0.7 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.1 1.4 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 1.3 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.1 0.5 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.1 1.2 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 0.6 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.1 0.8 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.1 0.2 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.1 0.3 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.1 0.4 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.1 0.7 GO:0071837 HMG box domain binding(GO:0071837)
0.1 1.7 GO:0070064 proline-rich region binding(GO:0070064)
0.1 1.1 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 0.3 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.0 1.3 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.6 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.6 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.4 GO:0070700 BMP receptor binding(GO:0070700)
0.0 1.1 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0 1.0 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.0 0.3 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.0 0.7 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.4 GO:0050897 cobalt ion binding(GO:0050897)
0.0 0.7 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.6 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.0 0.4 GO:0030275 LRR domain binding(GO:0030275)
0.0 0.1 GO:0097100 supercoiled DNA binding(GO:0097100)
0.0 2.4 GO:1990782 protein tyrosine kinase binding(GO:1990782)
0.0 0.6 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.8 GO:0046965 retinoid X receptor binding(GO:0046965)
0.0 2.4 GO:0002039 p53 binding(GO:0002039)
0.0 0.5 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.9 GO:0050681 androgen receptor binding(GO:0050681)
0.0 0.5 GO:0031402 sodium ion binding(GO:0031402)
0.0 8.8 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 0.8 GO:0005158 insulin receptor binding(GO:0005158)
0.0 13.4 GO:0003682 chromatin binding(GO:0003682)
0.0 0.2 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.8 GO:0042169 SH2 domain binding(GO:0042169)
0.0 0.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.4 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 0.3 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 0.3 GO:0004623 phospholipase A2 activity(GO:0004623)
0.0 0.2 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.1 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.2 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 7.6 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.2 10.3 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 12.4 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 2.4 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 1.8 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 2.1 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 1.1 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.0 0.9 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.5 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 1.5 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 1.0 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.9 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.0 0.8 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 1.2 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.0 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 0.8 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.5 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 0.7 PID_FGF_PATHWAY FGF signaling pathway
0.0 0.4 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.6 PID_CDC42_PATHWAY CDC42 signaling events
0.0 0.6 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.0 0.4 PID_ARF6_PATHWAY Arf6 signaling events
0.0 2.1 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.3 PID_SHP2_PATHWAY SHP2 signaling
0.0 0.6 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 0.2 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 2.9 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.4 2.4 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.3 3.7 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.2 3.8 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 0.4 REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS Genes involved in Hormone ligand-binding receptors
0.1 3.0 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 1.3 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.1 0.9 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.1 1.2 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.0 0.7 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.3 REACTOME_ACYL_CHAIN_REMODELLING_OF_PI Genes involved in Acyl chain remodelling of PI
0.0 0.5 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.8 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 0.6 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
0.0 0.5 REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 0.6 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.7 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.1 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.5 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling