Motif ID: Klf8

Z-value: 1.279


Transcription factors associated with Klf8:

Gene SymbolEntrez IDGene Name
Klf8 ENSMUSG00000041649.7 Klf8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Klf8mm10_v2_chrX_+_153237748_153237748-0.323.8e-02Click!


Activity profile for motif Klf8.

activity profile for motif Klf8


Sorted Z-values histogram for motif Klf8

Sorted Z-values for motif Klf8



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf8

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_72788952 12.688 ENSMUST00000114053.2
Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
chr17_-_70851189 11.940 ENSMUST00000059775.8
Tgif1
TGFB-induced factor homeobox 1
chr18_-_74961252 10.190 ENSMUST00000066532.4
Lipg
lipase, endothelial
chr13_-_60177357 9.646 ENSMUST00000065086.4
Gas1
growth arrest specific 1
chr2_-_36105271 9.606 ENSMUST00000112960.1
ENSMUST00000112967.5
ENSMUST00000112963.1
Lhx6


LIM homeobox protein 6


chr9_-_8004585 9.410 ENSMUST00000086580.5
ENSMUST00000065353.6
Yap1

yes-associated protein 1

chr14_-_103843685 8.485 ENSMUST00000172237.1
Ednrb
endothelin receptor type B
chr7_+_4119525 8.076 ENSMUST00000119661.1
ENSMUST00000129423.1
Ttyh1

tweety homolog 1 (Drosophila)

chr7_+_4119556 8.027 ENSMUST00000079415.5
Ttyh1
tweety homolog 1 (Drosophila)
chr4_+_46450892 6.953 ENSMUST00000102926.4
Anp32b
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr7_-_127026479 6.671 ENSMUST00000032916.4
Maz
MYC-associated zinc finger protein (purine-binding transcription factor)
chr18_-_78206408 6.511 ENSMUST00000163367.1
Slc14a2
solute carrier family 14 (urea transporter), member 2
chr1_+_172499948 6.152 ENSMUST00000111230.1
Tagln2
transgelin 2
chr10_+_4710119 5.899 ENSMUST00000105588.1
ENSMUST00000105589.1
Esr1

estrogen receptor 1 (alpha)

chr13_+_48261427 5.853 ENSMUST00000021810.1
Id4
inhibitor of DNA binding 4
chr1_-_20820213 5.712 ENSMUST00000053266.9
Mcm3
minichromosome maintenance deficient 3 (S. cerevisiae)
chr7_+_144838590 4.732 ENSMUST00000105898.1
Fgf3
fibroblast growth factor 3
chr7_-_144939823 4.594 ENSMUST00000093962.4
Ccnd1
cyclin D1
chr7_+_126847908 4.537 ENSMUST00000147257.1
ENSMUST00000139174.1
Doc2a

double C2, alpha

chr7_-_30973464 4.047 ENSMUST00000001279.8
Lsr
lipolysis stimulated lipoprotein receptor
chr12_-_69228167 3.846 ENSMUST00000021359.5
Pole2
polymerase (DNA directed), epsilon 2 (p59 subunit)
chr7_+_73391160 3.743 ENSMUST00000128471.1
Rgma
RGM domain family, member A
chr15_+_78926720 3.592 ENSMUST00000089377.5
Lgals1
lectin, galactose binding, soluble 1
chr2_+_172550991 3.567 ENSMUST00000170744.1
Tfap2c
transcription factor AP-2, gamma
chr15_-_75909543 3.486 ENSMUST00000123712.1
ENSMUST00000141475.1
ENSMUST00000144614.1
Eef1d


eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)


chr2_-_156839790 3.330 ENSMUST00000134838.1
ENSMUST00000137463.1
ENSMUST00000149275.2
Gm14230


predicted gene 14230


chr19_+_25610533 3.282 ENSMUST00000048935.4
Dmrt3
doublesex and mab-3 related transcription factor 3
chr15_+_39006272 3.106 ENSMUST00000179165.1
ENSMUST00000022906.7
Fzd6

frizzled homolog 6 (Drosophila)

chr11_-_109473220 3.081 ENSMUST00000070872.6
Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr1_+_191098414 2.926 ENSMUST00000027943.4
Batf3
basic leucine zipper transcription factor, ATF-like 3
chrX_-_51205990 2.874 ENSMUST00000114876.2
Mbnl3
muscleblind-like 3 (Drosophila)
chr18_+_60925612 2.866 ENSMUST00000102888.3
ENSMUST00000025519.4
Camk2a

calcium/calmodulin-dependent protein kinase II alpha

chr17_-_70851710 2.755 ENSMUST00000166395.2
Tgif1
TGFB-induced factor homeobox 1
chr14_+_65358661 2.744 ENSMUST00000066994.6
Zfp395
zinc finger protein 395
chr12_+_53248677 2.722 ENSMUST00000101432.2
Npas3
neuronal PAS domain protein 3
chr3_+_146500071 2.708 ENSMUST00000119130.1
Gng5
guanine nucleotide binding protein (G protein), gamma 5
chr5_-_114690974 2.685 ENSMUST00000012028.7
Gltp
glycolipid transfer protein
chr3_+_146499828 2.640 ENSMUST00000090031.5
Gng5
guanine nucleotide binding protein (G protein), gamma 5
chr3_+_94377432 2.638 ENSMUST00000107292.1
Rorc
RAR-related orphan receptor gamma
chr11_-_32222233 2.600 ENSMUST00000150381.1
ENSMUST00000144902.1
ENSMUST00000020524.8
Rhbdf1


rhomboid family 1 (Drosophila)


chr1_+_92831614 2.584 ENSMUST00000045970.6
Gpc1
glypican 1
chr2_+_27886416 2.558 ENSMUST00000028280.7
Col5a1
collagen, type V, alpha 1
chr11_+_69632927 2.539 ENSMUST00000018909.3
Fxr2
fragile X mental retardation, autosomal homolog 2
chr11_-_82871133 2.527 ENSMUST00000071152.7
ENSMUST00000108173.3
Rffl

ring finger and FYVE like domain containing protein

chr1_-_75505641 2.510 ENSMUST00000155084.1
Obsl1
obscurin-like 1
chr3_+_146499850 2.474 ENSMUST00000118280.1
Gng5
guanine nucleotide binding protein (G protein), gamma 5
chr3_+_121723515 2.418 ENSMUST00000029771.8
F3
coagulation factor III
chr3_+_87948666 2.395 ENSMUST00000005019.5
Crabp2
cellular retinoic acid binding protein II
chr3_+_94377505 2.352 ENSMUST00000098877.2
Rorc
RAR-related orphan receptor gamma
chr10_-_13388753 2.332 ENSMUST00000105546.1
Phactr2
phosphatase and actin regulator 2
chr10_-_80399478 2.322 ENSMUST00000092295.3
ENSMUST00000105349.1
Mbd3

methyl-CpG binding domain protein 3

chr3_-_89393294 2.292 ENSMUST00000142119.1
ENSMUST00000029677.8
ENSMUST00000148361.1
Zbtb7b


zinc finger and BTB domain containing 7B


chr10_-_13388830 2.275 ENSMUST00000079698.5
Phactr2
phosphatase and actin regulator 2
chr2_-_165473187 2.256 ENSMUST00000029208.8
ENSMUST00000109279.2
Slc13a3

solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3

chr16_-_18811615 2.242 ENSMUST00000096990.3
Cdc45
cell division cycle 45
chr13_-_3918157 2.211 ENSMUST00000091853.4
Net1
neuroepithelial cell transforming gene 1
chrX_+_71050160 2.185 ENSMUST00000082088.3
ENSMUST00000114629.3
Mamld1

mastermind-like domain containing 1

chr10_-_58675631 2.172 ENSMUST00000003312.4
Edar
ectodysplasin-A receptor
chr7_-_100656953 2.171 ENSMUST00000107046.1
ENSMUST00000107045.1
ENSMUST00000139708.1
Plekhb1


pleckstrin homology domain containing, family B (evectins) member 1


chr12_+_84009481 2.154 ENSMUST00000168120.1
Acot1
acyl-CoA thioesterase 1
chr2_+_156840077 2.128 ENSMUST00000081335.6
ENSMUST00000073352.3
Tgif2

TGFB-induced factor homeobox 2

chr4_-_97778042 2.127 ENSMUST00000146447.1
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr5_-_52566264 2.105 ENSMUST00000039750.5
Lgi2
leucine-rich repeat LGI family, member 2
chr12_+_8771405 2.101 ENSMUST00000171158.1
Sdc1
syndecan 1
chr1_-_106714217 2.047 ENSMUST00000112751.1
Bcl2
B cell leukemia/lymphoma 2
chr7_-_139582790 1.989 ENSMUST00000106095.2
Nkx6-2
NK6 homeobox 2
chr7_+_112427706 1.989 ENSMUST00000033030.7
Parva
parvin, alpha
chr8_+_114205590 1.946 ENSMUST00000049509.6
ENSMUST00000150963.1
Vat1l

vesicle amine transport protein 1 homolog-like (T. californica)

chr15_-_75909319 1.939 ENSMUST00000089680.3
ENSMUST00000141268.1
ENSMUST00000023235.6
ENSMUST00000109972.2
ENSMUST00000089681.5
ENSMUST00000109975.3
ENSMUST00000154584.1
Eef1d






eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)






chr17_+_34898931 1.938 ENSMUST00000097342.3
ENSMUST00000013931.5
Ehmt2

euchromatic histone lysine N-methyltransferase 2

chr10_-_77089428 1.889 ENSMUST00000156009.1
Col18a1
collagen, type XVIII, alpha 1
chr9_-_110742577 1.884 ENSMUST00000006005.7
Pth1r
parathyroid hormone 1 receptor
chr15_-_75909289 1.875 ENSMUST00000145764.1
ENSMUST00000116440.2
ENSMUST00000151066.1
Eef1d


eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)


chr7_-_93081027 1.845 ENSMUST00000098303.1
Gm9934
predicted gene 9934
chr9_+_66158206 1.825 ENSMUST00000034944.2
Dapk2
death-associated protein kinase 2
chrX_+_96096034 1.810 ENSMUST00000117399.1
Msn
moesin
chr7_-_63938862 1.765 ENSMUST00000063694.8
Klf13
Kruppel-like factor 13
chr12_+_8771317 1.757 ENSMUST00000020911.7
Sdc1
syndecan 1
chr3_+_87906321 1.710 ENSMUST00000005017.8
Hdgf
hepatoma-derived growth factor
chr17_-_24696147 1.686 ENSMUST00000046839.8
Gfer
growth factor, erv1 (S. cerevisiae)-like (augmenter of liver regeneration)
chr11_-_109472611 1.679 ENSMUST00000168740.1
Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr19_-_12765447 1.672 ENSMUST00000112933.1
Cntf
ciliary neurotrophic factor
chr18_+_74442500 1.640 ENSMUST00000074157.6
Myo5b
myosin VB
chr14_-_8666236 1.627 ENSMUST00000102996.3
4930452B06Rik
RIKEN cDNA 4930452B06 gene
chr11_-_67922136 1.610 ENSMUST00000021288.3
ENSMUST00000108677.1
Usp43

ubiquitin specific peptidase 43

chr2_-_54085542 1.607 ENSMUST00000100089.2
Rprm
reprimo, TP53 dependent G2 arrest mediator candidate
chr17_-_25868727 1.605 ENSMUST00000026828.5
Fam195a
family with sequence similarity 195, member A
chr4_-_57956283 1.586 ENSMUST00000030051.5
Txn1
thioredoxin 1
chr11_+_75655873 1.532 ENSMUST00000108431.2
Myo1c
myosin IC
chr15_+_89355730 1.513 ENSMUST00000074552.5
ENSMUST00000088717.6
Ncaph2

non-SMC condensin II complex, subunit H2

chr10_-_13193096 1.496 ENSMUST00000019950.4
Ltv1
LTV1 homolog (S. cerevisiae)
chrM_-_14060 1.479 ENSMUST00000082419.1
mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr17_+_86963077 1.456 ENSMUST00000024956.8
Rhoq
ras homolog gene family, member Q
chr2_+_109280738 1.446 ENSMUST00000028527.7
Kif18a
kinesin family member 18A
chr15_-_64312636 1.443 ENSMUST00000177083.1
ENSMUST00000177371.1
Asap1

ArfGAP with SH3 domain, ankyrin repeat and PH domain1

chr15_+_99702278 1.385 ENSMUST00000023759.4
Smarcd1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
chr10_+_94514825 1.382 ENSMUST00000065060.5
Tmcc3
transmembrane and coiled coil domains 3
chr15_+_89355716 1.380 ENSMUST00000036987.5
Ncaph2
non-SMC condensin II complex, subunit H2
chr10_-_5805412 1.366 ENSMUST00000019907.7
Fbxo5
F-box protein 5
chr13_+_49187485 1.352 ENSMUST00000049022.8
ENSMUST00000120733.1
Ninj1

ninjurin 1

chr19_+_8664005 1.296 ENSMUST00000035444.3
ENSMUST00000163785.1
Chrm1

cholinergic receptor, muscarinic 1, CNS

chrX_-_73921917 1.288 ENSMUST00000114389.3
Naa10
N(alpha)-acetyltransferase 10, NatA catalytic subunit
chr15_-_89355655 1.275 ENSMUST00000023283.5
Lmf2
lipase maturation factor 2
chr18_+_60925644 1.269 ENSMUST00000115297.1
Camk2a
calcium/calmodulin-dependent protein kinase II alpha
chr2_+_30416031 1.254 ENSMUST00000042055.3
Ppp2r4
protein phosphatase 2A, regulatory subunit B (PR 53)
chr11_-_102407455 1.251 ENSMUST00000107098.1
ENSMUST00000018821.2
Slc25a39

solute carrier family 25, member 39

chr2_+_30416096 1.222 ENSMUST00000113601.3
ENSMUST00000113603.3
Ppp2r4

protein phosphatase 2A, regulatory subunit B (PR 53)

chr1_-_75506331 1.220 ENSMUST00000113567.2
ENSMUST00000113565.2
Obsl1

obscurin-like 1

chr17_+_34898463 1.220 ENSMUST00000114033.2
ENSMUST00000078061.6
Ehmt2

euchromatic histone lysine N-methyltransferase 2

chrX_-_51205773 1.214 ENSMUST00000114875.1
Mbnl3
muscleblind-like 3 (Drosophila)
chr2_-_30093642 1.182 ENSMUST00000102865.4
Zdhhc12
zinc finger, DHHC domain containing 12
chr8_-_87959560 1.181 ENSMUST00000109655.2
Zfp423
zinc finger protein 423
chr4_+_148160613 1.161 ENSMUST00000047951.8
Fbxo2
F-box protein 2
chr17_+_46646225 1.155 ENSMUST00000002844.7
ENSMUST00000113429.1
ENSMUST00000113430.1
Mrpl2


mitochondrial ribosomal protein L2


chr5_+_139423151 1.140 ENSMUST00000066211.4
Gper1
G protein-coupled estrogen receptor 1
chr17_-_46705002 1.124 ENSMUST00000002839.8
Ppp2r5d
protein phosphatase 2, regulatory subunit B (B56), delta isoform
chr10_+_96616998 1.117 ENSMUST00000038377.7
Btg1
B cell translocation gene 1, anti-proliferative
chr16_+_64851991 1.112 ENSMUST00000067744.7
Cggbp1
CGG triplet repeat binding protein 1
chr7_+_126695355 1.103 ENSMUST00000130498.1
Bola2
bolA-like 2 (E. coli)
chr19_-_4615453 1.097 ENSMUST00000053597.2
Lrfn4
leucine rich repeat and fibronectin type III domain containing 4
chr11_+_60537978 1.096 ENSMUST00000044250.3
Alkbh5
alkB, alkylation repair homolog 5 (E. coli)
chr8_-_70659645 1.070 ENSMUST00000070173.7
Pgpep1
pyroglutamyl-peptidase I
chr4_-_57143437 1.064 ENSMUST00000095076.3
ENSMUST00000030142.3
Epb4.1l4b

erythrocyte protein band 4.1-like 4b

chr15_-_36608959 1.059 ENSMUST00000001809.8
Pabpc1
poly(A) binding protein, cytoplasmic 1
chr7_-_19399859 1.055 ENSMUST00000047170.3
ENSMUST00000108459.2
Klc3

kinesin light chain 3

chr1_-_182282738 1.032 ENSMUST00000035295.5
Degs1
degenerative spermatocyte homolog 1 (Drosophila)
chr14_+_122534305 1.030 ENSMUST00000154206.1
ENSMUST00000038374.6
ENSMUST00000135578.1
Pcca


propionyl-Coenzyme A carboxylase, alpha polypeptide


chr4_-_135873801 1.026 ENSMUST00000030436.5
Pnrc2
proline-rich nuclear receptor coactivator 2
chr6_+_124931378 1.020 ENSMUST00000032214.7
ENSMUST00000180095.1
Mlf2

myeloid leukemia factor 2

chrX_-_73921828 1.017 ENSMUST00000096316.3
ENSMUST00000114390.1
ENSMUST00000114391.3
ENSMUST00000114387.1
Naa10



N(alpha)-acetyltransferase 10, NatA catalytic subunit



chr11_-_69579320 1.008 ENSMUST00000048139.5
Wrap53
WD repeat containing, antisense to Trp53
chr8_+_105170668 1.005 ENSMUST00000109395.1
ENSMUST00000109394.1
ENSMUST00000052209.2
ENSMUST00000109392.1
Cbfb



core binding factor beta



chr19_+_46305682 0.996 ENSMUST00000111881.2
Nfkb2
nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
chrX_-_73921930 0.974 ENSMUST00000033763.8
Naa10
N(alpha)-acetyltransferase 10, NatA catalytic subunit
chr7_+_110627650 0.957 ENSMUST00000033054.8
Adm
adrenomedullin
chr11_-_102407315 0.944 ENSMUST00000149777.1
ENSMUST00000154001.1
Slc25a39

solute carrier family 25, member 39

chr6_+_43265582 0.920 ENSMUST00000031750.7
Arhgef5
Rho guanine nucleotide exchange factor (GEF) 5
chr2_-_65238625 0.909 ENSMUST00000112429.2
ENSMUST00000102726.1
ENSMUST00000112430.1
Cobll1


Cobl-like 1


chr7_-_31055594 0.907 ENSMUST00000039909.6
Fxyd1
FXYD domain-containing ion transport regulator 1
chr4_+_127169131 0.898 ENSMUST00000046659.7
Dlgap3
discs, large (Drosophila) homolog-associated protein 3
chr2_-_30093607 0.893 ENSMUST00000081838.6
Zdhhc12
zinc finger, DHHC domain containing 12
chr7_+_24884611 0.873 ENSMUST00000108428.1
Rps19
ribosomal protein S19
chr5_-_140649018 0.869 ENSMUST00000042661.3
Ttyh3
tweety homolog 3 (Drosophila)
chr17_-_27820445 0.867 ENSMUST00000114859.1
D17Wsu92e
DNA segment, Chr 17, Wayne State University 92, expressed
chr11_+_108920800 0.860 ENSMUST00000140821.1
Axin2
axin2
chr11_-_5261558 0.847 ENSMUST00000020662.8
Kremen1
kringle containing transmembrane protein 1
chr18_-_38250558 0.846 ENSMUST00000181757.1
1700086O06Rik
RIKEN cDNA 1700086O06 gene
chr9_+_114978507 0.842 ENSMUST00000183104.1
Osbpl10
oxysterol binding protein-like 10
chr8_+_3631109 0.840 ENSMUST00000004745.8
Stxbp2
syntaxin binding protein 2
chr3_+_129213920 0.837 ENSMUST00000042587.10
Pitx2
paired-like homeodomain transcription factor 2
chr10_+_99263224 0.836 ENSMUST00000020118.4
Dusp6
dual specificity phosphatase 6
chrX_+_161162994 0.821 ENSMUST00000077375.4
Scml2
sex comb on midleg-like 2 (Drosophila)
chr3_+_63295815 0.811 ENSMUST00000029400.1
Mme
membrane metallo endopeptidase
chr8_+_123477859 0.809 ENSMUST00000001520.7
Afg3l1
AFG3(ATPase family gene 3)-like 1 (yeast)
chr5_+_119834663 0.803 ENSMUST00000018407.6
Tbx5
T-box 5
chr11_-_69948145 0.783 ENSMUST00000179298.1
ENSMUST00000018710.6
ENSMUST00000135437.1
ENSMUST00000141837.2
ENSMUST00000142500.1
Slc2a4




solute carrier family 2 (facilitated glucose transporter), member 4




chr7_+_16843049 0.768 ENSMUST00000086104.4
Prkd2
protein kinase D2
chr16_+_20673517 0.766 ENSMUST00000115460.1
Eif4g1
eukaryotic translation initiation factor 4, gamma 1
chr5_+_110653444 0.701 ENSMUST00000031478.5
Ddx51
DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
chr1_-_168431695 0.696 ENSMUST00000176790.1
Pbx1
pre B cell leukemia homeobox 1
chr2_-_38644087 0.693 ENSMUST00000028083.5
Psmb7
proteasome (prosome, macropain) subunit, beta type 7
chr11_-_70656467 0.688 ENSMUST00000131642.1
Gm12319
predicted gene 12319
chr15_+_78406695 0.682 ENSMUST00000167140.1
Mpst
mercaptopyruvate sulfurtransferase
chr19_+_5740885 0.682 ENSMUST00000081496.5
Ltbp3
latent transforming growth factor beta binding protein 3
chr6_+_85187438 0.671 ENSMUST00000045942.8
Emx1
empty spiracles homeobox 1
chr7_+_30565410 0.651 ENSMUST00000043850.7
Igflr1
IGF-like family receptor 1
chr10_-_80798476 0.649 ENSMUST00000036805.5
Plekhj1
pleckstrin homology domain containing, family J member 1
chr16_+_93683184 0.643 ENSMUST00000039620.6
Cbr3
carbonyl reductase 3
chr2_+_32535315 0.639 ENSMUST00000133512.1
ENSMUST00000048375.5
Fam102a

family with sequence similarity 102, member A

chr19_-_4615647 0.634 ENSMUST00000113822.2
Lrfn4
leucine rich repeat and fibronectin type III domain containing 4
chr2_-_118703963 0.630 ENSMUST00000104937.1
Ankrd63
ankyrin repeat domain 63
chr2_+_27709247 0.628 ENSMUST00000100251.2
Rxra
retinoid X receptor alpha
chr5_+_143403819 0.620 ENSMUST00000110731.2
Kdelr2
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
chr15_+_78406777 0.618 ENSMUST00000169133.1
Mpst
mercaptopyruvate sulfurtransferase
chr11_+_70657196 0.610 ENSMUST00000157027.1
ENSMUST00000072841.5
ENSMUST00000108548.1
ENSMUST00000126241.1
Eno3



enolase 3, beta muscle



chr1_-_172027269 0.608 ENSMUST00000027837.6
ENSMUST00000111264.1
Vangl2

vang-like 2 (van gogh, Drosophila)

chr10_+_116301374 0.599 ENSMUST00000092167.5
Ptprb
protein tyrosine phosphatase, receptor type, B
chr7_-_31054815 0.577 ENSMUST00000071697.4
ENSMUST00000108110.3
Fxyd1

FXYD domain-containing ion transport regulator 1

chr11_-_62539257 0.572 ENSMUST00000018653.1
Cenpv
centromere protein V
chr7_-_127930066 0.562 ENSMUST00000032988.8
Prss8
protease, serine, 8 (prostasin)
chr9_-_106158109 0.558 ENSMUST00000159809.1
ENSMUST00000162562.1
ENSMUST00000036382.6
ENSMUST00000112543.2
Glyctk



glycerate kinase



chr4_-_150914401 0.553 ENSMUST00000105675.1
Park7
Parkinson disease (autosomal recessive, early onset) 7
chr5_+_74195281 0.552 ENSMUST00000051937.7
Rasl11b
RAS-like, family 11, member B
chr12_-_103242143 0.548 ENSMUST00000074416.3
Prima1
proline rich membrane anchor 1
chr15_-_50890396 0.545 ENSMUST00000185183.1
Trps1
trichorhinophalangeal syndrome I (human)
chr7_-_92874196 0.537 ENSMUST00000032877.9
4632434I11Rik
RIKEN cDNA 4632434I11 gene
chr4_+_123282778 0.533 ENSMUST00000106243.1
ENSMUST00000106241.1
ENSMUST00000080178.6
Pabpc4


poly(A) binding protein, cytoplasmic 4


chr7_+_16842896 0.524 ENSMUST00000168093.2
Prkd2
protein kinase D2
chr9_-_51077064 0.510 ENSMUST00000098782.3
Layn
layilin
chr11_+_98795495 0.500 ENSMUST00000037915.2
Msl1
male-specific lethal 1 homolog (Drosophila)
chrX_+_56963325 0.496 ENSMUST00000096431.3
Gpr112
G protein-coupled receptor 112
chr2_+_179893909 0.494 ENSMUST00000098996.1
Gm10711
predicted gene 10711
chr15_-_97767644 0.480 ENSMUST00000128775.2
ENSMUST00000134885.2
Rapgef3

Rap guanine nucleotide exchange factor (GEF) 3

chr19_-_10240689 0.463 ENSMUST00000088013.5
Myrf
myelin regulatory factor
chr13_-_29984219 0.460 ENSMUST00000146092.1
E2f3
E2F transcription factor 3
chr7_+_29238434 0.456 ENSMUST00000108237.1
Yif1b
Yip1 interacting factor homolog B (S. cerevisiae)
chr17_-_27820534 0.456 ENSMUST00000075076.4
ENSMUST00000114863.2
D17Wsu92e

DNA segment, Chr 17, Wayne State University 92, expressed

chr7_+_24884651 0.454 ENSMUST00000153451.2
ENSMUST00000108429.1
Rps19

ribosomal protein S19

chr10_+_94688739 0.447 ENSMUST00000020212.4
Ccdc41
coiled-coil domain containing 41
chr15_+_103453782 0.443 ENSMUST00000047405.7
Nckap1l
NCK associated protein 1 like

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 12.7 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
2.8 8.5 GO:0014826 vein smooth muscle contraction(GO:0014826)
2.5 10.2 GO:0010986 positive regulation of lipoprotein particle clearance(GO:0010986)
2.2 6.5 GO:0071918 urea transmembrane transport(GO:0071918)
1.6 9.6 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
1.6 6.3 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
1.6 9.4 GO:0060242 contact inhibition(GO:0060242)
1.5 5.9 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
1.4 8.6 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
1.3 4.0 GO:1904274 tricellular tight junction assembly(GO:1904274)
1.2 3.6 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
1.1 3.2 GO:0036166 phenotypic switching(GO:0036166)
1.0 3.1 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
1.0 9.6 GO:0042473 outer ear morphogenesis(GO:0042473)
1.0 6.7 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.9 14.7 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.9 2.6 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
0.9 2.6 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.8 2.4 GO:0010641 positive regulation of platelet-derived growth factor receptor signaling pathway(GO:0010641)
0.8 3.9 GO:1903553 positive regulation of extracellular exosome assembly(GO:1903553)
0.7 2.2 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) DNA replication preinitiation complex assembly(GO:0071163) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.7 3.7 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.7 3.7 GO:0046668 regulation of retinal cell programmed cell death(GO:0046668)
0.7 0.7 GO:1902460 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.7 4.7 GO:0030916 otic vesicle formation(GO:0030916)
0.7 4.6 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.7 3.3 GO:0018002 N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
0.6 3.8 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.6 2.5 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.6 5.0 GO:0072615 interleukin-17 secretion(GO:0072615)
0.6 1.8 GO:2000418 positive regulation of eosinophil migration(GO:2000418)
0.6 3.6 GO:0002317 plasma cell differentiation(GO:0002317) positive regulation of viral entry into host cell(GO:0046598)
0.6 2.9 GO:0051309 female meiosis chromosome separation(GO:0051309)
0.6 2.3 GO:0015744 succinate transport(GO:0015744)
0.4 0.8 GO:1903224 regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.4 2.9 GO:2001185 regulation of CD8-positive, alpha-beta T cell activation(GO:2001185)
0.4 16.1 GO:1902476 chloride transmembrane transport(GO:1902476)
0.3 1.4 GO:0007056 spindle assembly involved in female meiosis(GO:0007056)
0.3 3.7 GO:1900121 negative regulation of receptor binding(GO:1900121)
0.3 2.3 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.3 1.3 GO:0060265 positive regulation of respiratory burst involved in inflammatory response(GO:0060265)
0.3 3.3 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.3 4.1 GO:0099628 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
0.3 7.0 GO:0043486 histone exchange(GO:0043486)
0.3 0.9 GO:0002408 myeloid dendritic cell chemotaxis(GO:0002408)
0.3 1.5 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.3 0.9 GO:0061181 regulation of chondrocyte development(GO:0061181)
0.3 1.1 GO:1904706 regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579) negative regulation of vascular smooth muscle cell proliferation(GO:1904706) positive regulation of vascular smooth muscle cell differentiation(GO:1905065)
0.3 1.4 GO:1903527 positive regulation of membrane tubulation(GO:1903527)
0.3 1.1 GO:0035553 oxidative single-stranded RNA demethylation(GO:0035553)
0.3 1.6 GO:0032439 endosome localization(GO:0032439)
0.3 0.8 GO:0071492 cellular response to UV-A(GO:0071492)
0.3 1.3 GO:0019346 homoserine metabolic process(GO:0009092) transsulfuration(GO:0019346)
0.3 1.3 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.3 1.8 GO:1902965 cellular response to testosterone stimulus(GO:0071394) regulation of protein localization to early endosome(GO:1902965) positive regulation of protein localization to early endosome(GO:1902966)
0.3 1.3 GO:0089700 protein kinase D signaling(GO:0089700)
0.2 1.5 GO:1903275 positive regulation of sodium ion export(GO:1903275) positive regulation of sodium ion export from cell(GO:1903278) regulation of inorganic anion transmembrane transport(GO:1903795)
0.2 2.2 GO:0060662 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.2 1.7 GO:0097421 liver regeneration(GO:0097421)
0.2 2.4 GO:0048385 regulation of retinoic acid receptor signaling pathway(GO:0048385)
0.2 2.1 GO:0046826 negative regulation of protein export from nucleus(GO:0046826)
0.2 0.7 GO:0010725 regulation of primitive erythrocyte differentiation(GO:0010725)
0.2 1.5 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.2 1.1 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.2 0.8 GO:0060578 extraocular skeletal muscle development(GO:0002074) subthalamic nucleus development(GO:0021763) left lung development(GO:0060459) left lung morphogenesis(GO:0060460) pulmonary vein morphogenesis(GO:0060577) superior vena cava morphogenesis(GO:0060578)
0.2 7.3 GO:0009299 mRNA transcription(GO:0009299)
0.2 1.0 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
0.2 1.5 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.2 1.1 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.2 4.1 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.2 0.8 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.2 5.7 GO:0006270 DNA replication initiation(GO:0006270)
0.2 1.0 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.2 2.4 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.2 0.6 GO:0006447 regulation of translational initiation by iron(GO:0006447) positive regulation of translational initiation by iron(GO:0045994)
0.1 1.8 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.1 1.0 GO:0031086 nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.1 2.0 GO:0071670 smooth muscle cell chemotaxis(GO:0071670)
0.1 2.2 GO:0051451 myoblast migration(GO:0051451)
0.1 2.7 GO:0042711 maternal behavior(GO:0042711)
0.1 1.9 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.1 0.4 GO:1902949 positive regulation of tau-protein kinase activity(GO:1902949)
0.1 2.1 GO:0038092 nodal signaling pathway(GO:0038092)
0.1 0.4 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.1 4.4 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1 1.9 GO:0002076 osteoblast development(GO:0002076)
0.1 1.4 GO:0006337 nucleosome disassembly(GO:0006337)
0.1 0.4 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.1 0.7 GO:0031508 chromatin remodeling at centromere(GO:0031055) pericentric heterochromatin assembly(GO:0031508)
0.1 1.4 GO:0060033 anatomical structure regression(GO:0060033)
0.1 2.3 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)
0.1 0.5 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.1 0.6 GO:0006621 protein retention in ER lumen(GO:0006621)
0.1 0.2 GO:0003256 regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation(GO:0003256)
0.1 1.4 GO:0072520 seminiferous tubule development(GO:0072520)
0.1 1.2 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.1 0.7 GO:0060019 radial glial cell differentiation(GO:0060019)
0.1 0.2 GO:0019401 alditol biosynthetic process(GO:0019401)
0.1 2.1 GO:0018345 protein palmitoylation(GO:0018345)
0.1 0.4 GO:0034773 histone H4-K20 trimethylation(GO:0034773) establishment of Sertoli cell barrier(GO:0097368)
0.1 2.2 GO:0006783 heme biosynthetic process(GO:0006783)
0.1 0.8 GO:0033008 positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of mast cell degranulation(GO:0043306)
0.1 0.2 GO:0098974 postsynaptic actin cytoskeleton organization(GO:0098974)
0.1 1.0 GO:0002467 germinal center formation(GO:0002467)
0.1 0.7 GO:2000507 positive regulation of energy homeostasis(GO:2000507)
0.1 0.9 GO:0051639 actin filament network formation(GO:0051639)
0.1 0.4 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.1 0.6 GO:0042135 neurotransmitter catabolic process(GO:0042135)
0.1 0.2 GO:0014005 microglia differentiation(GO:0014004) microglia development(GO:0014005)
0.1 0.5 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.1 0.8 GO:0034982 mitochondrial protein processing(GO:0034982)
0.0 0.6 GO:0042182 ketone catabolic process(GO:0042182)
0.0 0.6 GO:0070633 transepithelial transport(GO:0070633)
0.0 1.0 GO:0060216 definitive hemopoiesis(GO:0060216)
0.0 1.5 GO:1903077 negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.0 1.2 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 0.2 GO:2000210 positive regulation of anoikis(GO:2000210)
0.0 0.8 GO:0044381 glucose import in response to insulin stimulus(GO:0044381)
0.0 0.2 GO:0000019 regulation of mitotic recombination(GO:0000019) telomeric 3' overhang formation(GO:0031860)
0.0 0.4 GO:0046697 decidualization(GO:0046697)
0.0 0.8 GO:0030279 negative regulation of ossification(GO:0030279)
0.0 0.8 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.0 0.2 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 2.6 GO:0050709 negative regulation of protein secretion(GO:0050709)
0.0 0.1 GO:0060903 positive regulation of meiosis I(GO:0060903)
0.0 2.2 GO:0035383 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.0 0.2 GO:0051764 actin crosslink formation(GO:0051764)
0.0 0.5 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 1.0 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 1.2 GO:0032543 mitochondrial translation(GO:0032543)
0.0 0.2 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.0 0.3 GO:0045780 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.0 1.7 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.0 0.2 GO:0046498 S-adenosylhomocysteine metabolic process(GO:0046498)
0.0 0.7 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 0.4 GO:0006073 glycogen metabolic process(GO:0005977) cellular glucan metabolic process(GO:0006073) glucan metabolic process(GO:0044042) cellular polysaccharide metabolic process(GO:0044264)
0.0 0.1 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.0 0.5 GO:0032330 regulation of chondrocyte differentiation(GO:0032330)
0.0 0.4 GO:0000154 rRNA modification(GO:0000154)
0.0 0.8 GO:0006096 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
5.4 16.1 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
3.1 9.4 GO:0071149 TEAD-2-YAP complex(GO:0071149)
2.6 7.8 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
1.4 4.1 GO:0099573 glutamatergic postsynaptic density(GO:0099573)
1.2 7.3 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.9 2.6 GO:0005588 collagen type V trimer(GO:0005588)
0.8 5.9 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.8 3.8 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.7 2.2 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.7 4.0 GO:0061689 tricellular tight junction(GO:0061689)
0.6 3.7 GO:0005859 muscle myosin complex(GO:0005859)
0.6 1.7 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.5 1.5 GO:0045160 myosin I complex(GO:0045160)
0.4 3.3 GO:0031415 NatA complex(GO:0031415)
0.4 5.7 GO:0042555 MCM complex(GO:0042555)
0.3 10.2 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.3 2.9 GO:0000796 condensin complex(GO:0000796)
0.3 0.8 GO:0044194 cytolytic granule(GO:0044194)
0.2 1.5 GO:0034448 EGO complex(GO:0034448)
0.2 1.4 GO:0005828 kinetochore microtubule(GO:0005828)
0.2 0.8 GO:0005745 m-AAA complex(GO:0005745)
0.2 1.8 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.2 2.0 GO:0046930 pore complex(GO:0046930)
0.1 1.0 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.1 3.1 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 0.4 GO:0000814 ESCRT II complex(GO:0000814)
0.1 1.1 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 0.9 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 0.5 GO:0072487 MSL complex(GO:0072487)
0.1 0.8 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 0.4 GO:0060187 cell pole(GO:0060187)
0.1 1.2 GO:0032279 asymmetric synapse(GO:0032279)
0.1 1.4 GO:0071564 npBAF complex(GO:0071564)
0.1 0.8 GO:0031209 SCAR complex(GO:0031209)
0.1 6.6 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 0.4 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.1 1.1 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 1.1 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.5 GO:0034464 BBSome(GO:0034464)
0.0 17.4 GO:0005667 transcription factor complex(GO:0005667)
0.0 2.5 GO:0005844 polysome(GO:0005844)
0.0 1.0 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 1.6 GO:0002102 podosome(GO:0002102)
0.0 0.5 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.8 GO:0001741 XY body(GO:0001741)
0.0 0.7 GO:0005839 proteasome core complex(GO:0005839)
0.0 0.8 GO:0005771 multivesicular body(GO:0005771)
0.0 0.5 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 1.3 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 1.0 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 0.2 GO:0030870 Mre11 complex(GO:0030870)
0.0 1.9 GO:0005581 collagen trimer(GO:0005581)
0.0 6.0 GO:0031965 nuclear membrane(GO:0031965)
0.0 0.1 GO:0070876 SOSS complex(GO:0070876)
0.0 0.4 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 1.2 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.6 GO:0051233 spindle midzone(GO:0051233)
0.0 1.5 GO:0005884 actin filament(GO:0005884)
0.0 1.5 GO:0070469 respiratory chain(GO:0070469)
0.0 0.8 GO:0016459 myosin complex(GO:0016459)
0.0 1.2 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.1 GO:0001740 Barr body(GO:0001740)
0.0 3.9 GO:0005769 early endosome(GO:0005769)
0.0 1.5 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.4 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 1.5 GO:0010008 endosome membrane(GO:0010008)
0.0 5.1 GO:0031012 extracellular matrix(GO:0031012)
0.0 0.6 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.0 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.7 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.2 GO:0032039 integrator complex(GO:0032039)
0.0 0.5 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) integral component of Golgi membrane(GO:0030173)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.0 16.1 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
2.8 8.5 GO:0004962 endothelin receptor activity(GO:0004962)
2.5 10.2 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
2.0 5.9 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
1.2 5.0 GO:0008142 oxysterol binding(GO:0008142)
1.1 6.5 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.9 2.6 GO:0070052 collagen V binding(GO:0070052)
0.8 2.3 GO:0017153 sodium:dicarboxylate symporter activity(GO:0017153)
0.7 3.7 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.7 3.6 GO:0005534 galactose binding(GO:0005534)
0.7 14.7 GO:0070410 co-SMAD binding(GO:0070410)
0.7 3.3 GO:1990190 peptide-glutamate-N-acetyltransferase activity(GO:1990190)
0.5 3.2 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.4 12.4 GO:0070064 proline-rich region binding(GO:0070064)
0.4 1.7 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.4 2.4 GO:0019841 retinol binding(GO:0019841)
0.4 1.1 GO:0030284 estrogen receptor activity(GO:0030284)
0.3 4.1 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.3 1.0 GO:0042284 sphingolipid delta-4 desaturase activity(GO:0042284)
0.3 1.0 GO:0004658 propionyl-CoA carboxylase activity(GO:0004658)
0.3 1.6 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.3 7.3 GO:0003746 translation elongation factor activity(GO:0003746)
0.3 3.7 GO:1990459 transferrin receptor binding(GO:1990459)
0.3 1.1 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.3 1.3 GO:0004792 thiosulfate sulfurtransferase activity(GO:0004792)
0.3 1.3 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.3 4.0 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.2 1.7 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.2 2.0 GO:0051434 BH3 domain binding(GO:0051434)
0.2 0.6 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.2 0.8 GO:0030348 syntaxin-3 binding(GO:0030348)
0.2 0.4 GO:0004921 interleukin-11 receptor activity(GO:0004921) interleukin-11 binding(GO:0019970)
0.2 0.8 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.2 1.4 GO:1990948 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.2 0.6 GO:0036470 tyrosine 3-monooxygenase activator activity(GO:0036470) L-dopa decarboxylase activator activity(GO:0036478)
0.2 2.6 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.2 2.2 GO:0003688 DNA replication origin binding(GO:0003688)
0.2 2.7 GO:0051861 glycolipid binding(GO:0051861)
0.2 0.6 GO:0046923 ER retention sequence binding(GO:0046923)
0.2 1.1 GO:0008242 omega peptidase activity(GO:0008242)
0.1 3.8 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 3.1 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 2.2 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.1 1.4 GO:0005522 profilin binding(GO:0005522)
0.1 0.6 GO:0070644 vitamin D response element binding(GO:0070644)
0.1 0.9 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 2.2 GO:0017049 GTP-Rho binding(GO:0017049)
0.1 4.0 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.1 0.4 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.1 0.4 GO:0034648 histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.1 1.7 GO:0001222 transcription corepressor binding(GO:0001222)
0.1 8.6 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.1 1.4 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 1.8 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 0.9 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.1 5.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 1.6 GO:0008143 poly(A) binding(GO:0008143)
0.1 2.1 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 0.6 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.1 0.8 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.1 1.5 GO:0017160 Ral GTPase binding(GO:0017160)
0.1 0.2 GO:0098973 structural constituent of synapse(GO:0098918) structural constituent of postsynaptic actin cytoskeleton(GO:0098973)
0.1 0.9 GO:0070411 I-SMAD binding(GO:0070411)
0.1 0.4 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.1 0.2 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.1 1.0 GO:0070034 telomerase RNA binding(GO:0070034)
0.1 0.8 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 5.0 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1 0.2 GO:0008967 phosphoglycolate phosphatase activity(GO:0008967)
0.1 1.5 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.5 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.2 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0 5.1 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 1.3 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 0.7 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 0.2 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.0 0.5 GO:0043495 protein anchor(GO:0043495)
0.0 0.8 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 1.6 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 1.4 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 3.1 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.1 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0 0.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.7 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 4.9 GO:0004386 helicase activity(GO:0004386)
0.0 0.9 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 3.5 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.8 GO:0017046 peptide hormone binding(GO:0017046)
0.0 0.1 GO:0051378 serotonin binding(GO:0051378)
0.0 1.5 GO:0002039 p53 binding(GO:0002039)
0.0 0.4 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.3 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 0.4 GO:0001054 RNA polymerase I activity(GO:0001054)
0.0 1.6 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 1.1 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 1.1 GO:0019894 kinesin binding(GO:0019894)
0.0 3.3 GO:0042393 histone binding(GO:0042393)
0.0 6.5 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 0.1 GO:0001165 RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165)
0.0 1.8 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0 1.4 GO:0043130 ubiquitin binding(GO:0043130)
0.0 7.2 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.0 2.9 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 0.6 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.1 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 3.9 GO:0045296 cadherin binding(GO:0045296)
0.0 0.0 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.8 GO:0008238 exopeptidase activity(GO:0008238)
0.0 0.4 GO:0048365 Rac GTPase binding(GO:0048365)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 24.7 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.4 19.8 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.2 2.0 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.2 3.9 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.2 4.1 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.2 15.8 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.2 9.1 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.1 6.5 PID_E2F_PATHWAY E2F transcription factor network
0.1 3.2 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 1.5 PID_INSULIN_PATHWAY Insulin Pathway
0.1 3.7 PID_BMP_PATHWAY BMP receptor signaling
0.1 3.0 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 3.8 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 1.9 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 1.8 ST_GAQ_PATHWAY G alpha q Pathway
0.1 0.9 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.0 5.6 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.9 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 1.2 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 2.5 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 1.1 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 2.2 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.0 2.9 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 2.0 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 0.6 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.7 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.0 PID_PLK1_PATHWAY PLK1 signaling events
0.0 0.9 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling
0.0 0.4 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 1.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.1 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 0.4 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 8.0 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.5 16.8 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.4 4.7 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.4 13.0 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.3 6.4 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.3 5.6 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.3 3.8 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.3 7.8 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.3 2.3 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.2 6.9 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.2 2.4 REACTOME_FORMATION_OF_FIBRIN_CLOT_CLOTTING_CASCADE Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.1 2.0 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes
0.1 2.0 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.1 3.6 REACTOME_RNA_POL_I_TRANSCRIPTION_INITIATION Genes involved in RNA Polymerase I Transcription Initiation
0.1 1.3 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 1.4 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 7.6 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 1.2 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.1 2.5 REACTOME_KINESINS Genes involved in Kinesins
0.1 4.1 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
0.1 2.0 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 1.0 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.1 0.8 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 4.6 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 1.8 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.1 1.0 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 0.4 REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.1 3.0 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 1.6 REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.1 2.7 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.0 REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 7.3 REACTOME_TRANSLATION Genes involved in Translation
0.0 0.8 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 1.5 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.0 1.7 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 1.7 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.9 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 2.0 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 1.0 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.3 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.4 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.3 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.4 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.7 REACTOME_CDK_MEDIATED_PHOSPHORYLATION_AND_REMOVAL_OF_CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.0 0.2 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.2 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks