Motif ID: Stat6

Z-value: 1.050


Transcription factors associated with Stat6:

Gene SymbolEntrez IDGene Name
Stat6 ENSMUSG00000002147.12 Stat6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Stat6mm10_v2_chr10_+_127642975_127643034-0.163.3e-01Click!


Activity profile for motif Stat6.

activity profile for motif Stat6


Sorted Z-values histogram for motif Stat6

Sorted Z-values for motif Stat6



Network of associatons between targets according to the STRING database.



First level regulatory network of Stat6

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_-_23890805 8.569 ENSMUST00000004480.3
Sst
somatostatin
chr14_-_21989475 7.872 ENSMUST00000043409.7
Zfp503
zinc finger protein 503
chr11_-_55419898 6.815 ENSMUST00000108858.1
ENSMUST00000141530.1
Sparc

secreted acidic cysteine rich glycoprotein

chr4_+_136143497 6.072 ENSMUST00000008016.2
Id3
inhibitor of DNA binding 3
chr18_+_50053282 5.962 ENSMUST00000148159.2
Tnfaip8
tumor necrosis factor, alpha-induced protein 8
chr9_-_70421533 5.888 ENSMUST00000034742.6
Ccnb2
cyclin B2
chr2_+_70562854 5.770 ENSMUST00000130998.1
Gad1
glutamate decarboxylase 1
chr2_+_70563435 5.678 ENSMUST00000123330.1
Gad1
glutamate decarboxylase 1
chr10_-_78591945 5.307 ENSMUST00000040580.6
Syde1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr2_+_163225363 5.295 ENSMUST00000099110.3
ENSMUST00000165937.1
Tox2

TOX high mobility group box family member 2

chr3_+_67892189 5.211 ENSMUST00000063263.3
Iqcj
IQ motif containing J
chr15_-_82244716 5.128 ENSMUST00000089155.4
ENSMUST00000089157.3
Cenpm

centromere protein M

chr11_-_102579461 4.861 ENSMUST00000107081.1
Gm11627
predicted gene 11627
chr17_-_89910449 4.649 ENSMUST00000086423.4
Gm10184
predicted pseudogene 10184
chr5_+_139543889 3.917 ENSMUST00000174792.1
ENSMUST00000031523.8
Uncx

UNC homeobox

chr1_-_120121030 3.887 ENSMUST00000027634.6
Dbi
diazepam binding inhibitor
chr2_-_51972990 3.232 ENSMUST00000145481.1
ENSMUST00000112705.2
Nmi

N-myc (and STAT) interactor

chr2_+_30077684 3.171 ENSMUST00000125346.1
Pkn3
protein kinase N3
chr2_-_113848655 2.961 ENSMUST00000102545.1
ENSMUST00000110948.1
Arhgap11a

Rho GTPase activating protein 11A

chr7_-_126800354 2.782 ENSMUST00000106348.1
Aldoa
aldolase A, fructose-bisphosphate
chr1_+_146497614 2.689 ENSMUST00000132847.1
ENSMUST00000166814.1
Brinp3

bone morphogenetic protein/retinoic acid inducible neural specific 3

chr2_-_113848601 2.452 ENSMUST00000110949.2
Arhgap11a
Rho GTPase activating protein 11A
chr4_-_116708312 2.382 ENSMUST00000030453.4
Mmachc
methylmalonic aciduria cblC type, with homocystinuria
chr17_+_29090969 2.362 ENSMUST00000119901.1
Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr2_-_101628930 2.280 ENSMUST00000099682.2
B230118H07Rik
RIKEN cDNA B230118H07 gene
chr9_-_35176039 2.218 ENSMUST00000119847.1
ENSMUST00000034539.5
Dcps

decapping enzyme, scavenger

chr14_-_65425453 2.215 ENSMUST00000059339.5
Pnoc
prepronociceptin
chr15_-_33405976 2.192 ENSMUST00000079057.6
1700084J12Rik
RIKEN cDNA 1700084J12 gene
chr8_-_47990535 2.185 ENSMUST00000057561.7
Wwc2
WW, C2 and coiled-coil domain containing 2
chr8_-_106573461 2.133 ENSMUST00000073722.5
Gm10073
predicted pseudogene 10073
chr7_-_126800036 2.094 ENSMUST00000133514.1
ENSMUST00000151137.1
Aldoa

aldolase A, fructose-bisphosphate

chr4_+_116708467 2.007 ENSMUST00000030452.6
Ccdc163
coiled-coil domain containing 163
chr13_+_99100698 1.967 ENSMUST00000181742.1
Gm807
predicted gene 807
chr2_-_73453918 1.955 ENSMUST00000102679.1
Wipf1
WAS/WASL interacting protein family, member 1
chr2_-_101628958 1.881 ENSMUST00000111231.3
B230118H07Rik
RIKEN cDNA B230118H07 gene
chr4_+_32983008 1.852 ENSMUST00000098190.3
ENSMUST00000029946.7
Rragd

Ras-related GTP binding D

chr11_-_11890394 1.837 ENSMUST00000109659.2
Ddc
dopa decarboxylase
chr7_-_127286385 1.763 ENSMUST00000172206.2
Gm17511
predicted gene, 17511
chr7_-_38227975 1.740 ENSMUST00000098513.4
Plekhf1
pleckstrin homology domain containing, family F (with FYVE domain) member 1
chr19_-_50030735 1.692 ENSMUST00000071866.1
Rpl13a-ps1
ribosomal protein 13A, pseudogene 1
chr14_+_20703027 1.658 ENSMUST00000071215.3
Chchd1
coiled-coil-helix-coiled-coil-helix domain containing 1
chr10_+_97479470 1.591 ENSMUST00000105287.3
Dcn
decorin
chr1_-_126738167 1.547 ENSMUST00000160693.1
Nckap5
NCK-associated protein 5
chr6_+_66896397 1.541 ENSMUST00000043148.6
ENSMUST00000114228.1
ENSMUST00000114227.1
ENSMUST00000114226.1
ENSMUST00000114225.1
ENSMUST00000114224.1
Gng12





guanine nucleotide binding protein (G protein), gamma 12





chr3_-_141931523 1.520 ENSMUST00000106232.1
Bmpr1b
bone morphogenetic protein receptor, type 1B
chr6_-_4086914 1.508 ENSMUST00000049166.4
Bet1
blocked early in transport 1 homolog (S. cerevisiae)
chr3_+_102010138 1.500 ENSMUST00000066187.4
Nhlh2
nescient helix loop helix 2
chr3_-_8923796 1.495 ENSMUST00000042148.5
Mrps28
mitochondrial ribosomal protein S28
chr15_+_32920723 1.443 ENSMUST00000022871.5
Sdc2
syndecan 2
chr1_+_146495621 1.442 ENSMUST00000074622.4
Brinp3
bone morphogenetic protein/retinoic acid inducible neural specific 3
chr1_+_134182404 1.441 ENSMUST00000153856.1
ENSMUST00000082060.3
ENSMUST00000133701.1
ENSMUST00000132873.1
Chi3l1



chitinase 3-like 1



chrX_-_53269786 1.427 ENSMUST00000114841.1
ENSMUST00000071023.5
Fam122b

family with sequence similarity 122, member B

chr7_-_90129339 1.405 ENSMUST00000181189.1
2310010J17Rik
RIKEN cDNA 2310010J17 gene
chr3_+_14641722 1.404 ENSMUST00000029071.8
Car13
carbonic anhydrase 13
chr11_-_11890368 1.403 ENSMUST00000155690.1
Ddc
dopa decarboxylase
chr4_+_116708571 1.398 ENSMUST00000106462.2
ENSMUST00000138305.1
ENSMUST00000125671.1
ENSMUST00000130828.1
Ccdc163



coiled-coil domain containing 163



chr3_-_86548268 1.298 ENSMUST00000077524.3
Mab21l2
mab-21-like 2 (C. elegans)
chr10_+_81070035 1.280 ENSMUST00000005057.6
Thop1
thimet oligopeptidase 1
chr13_-_91388079 1.253 ENSMUST00000181054.1
A830009L08Rik
RIKEN cDNA A830009L08 gene
chr4_+_116708624 1.229 ENSMUST00000106463.1
Ccdc163
coiled-coil domain containing 163
chr10_-_128626464 1.201 ENSMUST00000026420.5
Rps26
ribosomal protein S26
chr7_+_28350652 1.188 ENSMUST00000082134.4
Rps16
ribosomal protein S16
chr1_+_134182150 1.151 ENSMUST00000156873.1
Chi3l1
chitinase 3-like 1
chr4_+_116708687 1.122 ENSMUST00000135499.1
Ccdc163
coiled-coil domain containing 163
chr15_-_81926148 1.084 ENSMUST00000023113.5
Polr3h
polymerase (RNA) III (DNA directed) polypeptide H
chr11_-_78183551 1.057 ENSMUST00000102483.4
Rpl23a
ribosomal protein L23A
chr1_+_88227005 1.056 ENSMUST00000061013.6
ENSMUST00000113130.1
Mroh2a

maestro heat-like repeat family member 2A

chr5_-_106574706 1.023 ENSMUST00000131029.1
ENSMUST00000124394.2
RP24-421H18.1

RP24-421H18.1

chr14_+_75845093 1.015 ENSMUST00000110894.2
Tpt1
tumor protein, translationally-controlled 1
chr18_-_36726730 0.982 ENSMUST00000061829.6
Cd14
CD14 antigen
chr1_-_175625580 0.930 ENSMUST00000027810.7
Fh1
fumarate hydratase 1
chr4_-_117125618 0.925 ENSMUST00000183310.1
Btbd19
BTB (POZ) domain containing 19
chr16_-_56712825 0.924 ENSMUST00000136394.1
Tfg
Trk-fused gene
chr13_-_115090123 0.921 ENSMUST00000109226.3
Pelo
pelota homolog (Drosophila)
chr1_-_125913101 0.895 ENSMUST00000161361.1
Lypd1
Ly6/Plaur domain containing 1
chr1_-_44118757 0.874 ENSMUST00000027213.7
ENSMUST00000065767.2
Kdelc1

KDEL (Lys-Asp-Glu-Leu) containing 1

chr3_+_97032416 0.873 ENSMUST00000132256.1
ENSMUST00000072600.6
Gja5

gap junction protein, alpha 5

chr5_-_24445166 0.865 ENSMUST00000115043.1
ENSMUST00000115041.1
Fastk

Fas-activated serine/threonine kinase

chr2_-_30093642 0.859 ENSMUST00000102865.4
Zdhhc12
zinc finger, DHHC domain containing 12
chr7_-_70366735 0.832 ENSMUST00000089565.5
Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr7_-_44816586 0.816 ENSMUST00000047356.8
Atf5
activating transcription factor 5
chr9_+_109054839 0.815 ENSMUST00000154184.1
Shisa5
shisa homolog 5 (Xenopus laevis)
chr16_-_22265950 0.809 ENSMUST00000161286.1
Tra2b
transformer 2 beta homolog (Drosophila)
chr2_-_125723387 0.797 ENSMUST00000042246.7
Shc4
SHC (Src homology 2 domain containing) family, member 4
chr11_-_3914664 0.791 ENSMUST00000109995.1
ENSMUST00000051207.1
Slc35e4

solute carrier family 35, member E4

chr5_+_31054821 0.771 ENSMUST00000174367.1
ENSMUST00000170329.1
ENSMUST00000031049.6
Cad


carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase


chr11_+_108587077 0.759 ENSMUST00000146912.2
Cep112
centrosomal protein 112
chr18_+_66458587 0.755 ENSMUST00000025399.7
Pmaip1
phorbol-12-myristate-13-acetate-induced protein 1
chr7_+_107567445 0.742 ENSMUST00000120990.1
Olfml1
olfactomedin-like 1
chr15_+_59648350 0.735 ENSMUST00000067543.6
Trib1
tribbles homolog 1 (Drosophila)
chr6_+_66896480 0.732 ENSMUST00000114222.1
Gng12
guanine nucleotide binding protein (G protein), gamma 12
chr5_+_31054766 0.717 ENSMUST00000013773.5
ENSMUST00000114646.1
Cad

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

chr2_-_30093607 0.673 ENSMUST00000081838.6
Zdhhc12
zinc finger, DHHC domain containing 12
chr9_+_75037809 0.668 ENSMUST00000167885.1
Arpp19
cAMP-regulated phosphoprotein 19
chr2_-_14056029 0.665 ENSMUST00000074854.7
Ptpla
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member a
chr9_+_109054903 0.664 ENSMUST00000151141.1
ENSMUST00000152771.1
Shisa5

shisa homolog 5 (Xenopus laevis)

chr1_-_125912160 0.653 ENSMUST00000159417.1
Lypd1
Ly6/Plaur domain containing 1
chrX_-_140956675 0.633 ENSMUST00000033805.8
ENSMUST00000112978.1
Psmd10

proteasome (prosome, macropain) 26S subunit, non-ATPase, 10

chr5_-_24445254 0.605 ENSMUST00000030800.6
Fastk
Fas-activated serine/threonine kinase
chr14_-_55758458 0.583 ENSMUST00000001497.7
Cideb
cell death-inducing DNA fragmentation factor, alpha subunit-like effector B
chr7_+_101348061 0.572 ENSMUST00000107010.2
Arap1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr7_+_140882430 0.571 ENSMUST00000164681.1
ENSMUST00000163610.1
Psmd13

proteasome (prosome, macropain) 26S subunit, non-ATPase, 13

chr19_+_12846773 0.570 ENSMUST00000164001.1
Gm5244
predicted pseudogene 5244
chr11_+_82035569 0.510 ENSMUST00000000193.5
Ccl2
chemokine (C-C motif) ligand 2
chr9_+_75037838 0.502 ENSMUST00000169188.1
Arpp19
cAMP-regulated phosphoprotein 19
chr9_+_44066993 0.495 ENSMUST00000034508.7
Usp2
ubiquitin specific peptidase 2
chr8_-_105758570 0.494 ENSMUST00000155038.2
ENSMUST00000013294.9
Gfod2

glucose-fructose oxidoreductase domain containing 2

chr12_+_37108533 0.489 ENSMUST00000041183.5
Meox2
mesenchyme homeobox 2
chr1_+_156035392 0.487 ENSMUST00000111757.3
Tor1aip2
torsin A interacting protein 2
chr13_-_23683941 0.485 ENSMUST00000171127.1
Hist1h2ac
histone cluster 1, H2ac
chr2_-_14055963 0.479 ENSMUST00000091429.5
ENSMUST00000114753.1
Ptpla

protein tyrosine phosphatase-like (proline instead of catalytic arginine), member a

chr4_-_43454582 0.468 ENSMUST00000107925.1
Cd72
CD72 antigen
chr2_-_147186389 0.450 ENSMUST00000109970.3
ENSMUST00000067075.5
Nkx2-2

NK2 homeobox 2

chr7_+_44816088 0.435 ENSMUST00000057195.9
ENSMUST00000107891.1
Nup62

nucleoporin 62

chr9_+_75037744 0.430 ENSMUST00000168301.1
Arpp19
cAMP-regulated phosphoprotein 19
chr4_-_43454563 0.408 ENSMUST00000107926.1
Cd72
CD72 antigen
chr17_+_28232723 0.391 ENSMUST00000002320.8
Ppard
peroxisome proliferator activator receptor delta
chr18_+_24205937 0.388 ENSMUST00000164998.1
Galnt1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1
chr3_-_96293953 0.363 ENSMUST00000029748.3
Fcgr1
Fc receptor, IgG, high affinity I
chr4_+_120666562 0.329 ENSMUST00000094814.4
Cited4
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
chr3_-_87263703 0.301 ENSMUST00000146512.1
Fcrls
Fc receptor-like S, scavenger receptor
chr12_-_15816762 0.299 ENSMUST00000020922.7
Trib2
tribbles homolog 2 (Drosophila)
chr17_-_34187219 0.269 ENSMUST00000173831.1
Psmb9
proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
chr12_-_59219725 0.265 ENSMUST00000043204.7
Fbxo33
F-box protein 33
chr5_+_21372642 0.258 ENSMUST00000035799.5
Fgl2
fibrinogen-like protein 2
chr11_-_106779483 0.234 ENSMUST00000021060.5
Polg2
polymerase (DNA directed), gamma 2, accessory subunit
chr15_+_25773985 0.226 ENSMUST00000125667.1
Myo10
myosin X
chr10_+_43901782 0.225 ENSMUST00000054418.5
Rtn4ip1
reticulon 4 interacting protein 1
chr9_+_44067072 0.224 ENSMUST00000177054.1
Usp2
ubiquitin specific peptidase 2
chr2_-_125858985 0.177 ENSMUST00000110462.1
Cops2
COP9 (constitutive photomorphogenic) homolog, subunit 2 (Arabidopsis thaliana)
chr15_+_6422240 0.174 ENSMUST00000163082.1
Dab2
disabled 2, mitogen-responsive phosphoprotein
chr1_+_59516264 0.170 ENSMUST00000114243.1
Gm973
predicted gene 973
chrX_+_7841800 0.158 ENSMUST00000033494.9
ENSMUST00000115666.1
Otud5

OTU domain containing 5

chr9_+_75051977 0.152 ENSMUST00000170310.1
ENSMUST00000166549.1
Arpp19

cAMP-regulated phosphoprotein 19

chr9_+_86743641 0.145 ENSMUST00000179574.1
Prss35
protease, serine, 35
chr14_+_79587691 0.127 ENSMUST00000054908.8
Sugt1
SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)
chr1_+_173673651 0.111 ENSMUST00000085876.4
Pydc3
pyrin domain containing 3
chr12_-_57197311 0.106 ENSMUST00000044634.5
Slc25a21
solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21
chr7_+_81213567 0.071 ENSMUST00000026672.7
Pde8a
phosphodiesterase 8A
chrX_+_7842056 0.066 ENSMUST00000115667.3
ENSMUST00000115668.3
ENSMUST00000115665.1
Otud5


OTU domain containing 5


chrX_+_134756563 0.061 ENSMUST00000081834.3
ENSMUST00000086880.4
ENSMUST00000086884.4
Armcx3


armadillo repeat containing, X-linked 3


chr9_+_112234257 0.050 ENSMUST00000149308.3
ENSMUST00000144424.2
ENSMUST00000139552.2
2900079G21Rik


RIKEN cDNA 2900079G21 gene


chr12_-_87233556 0.029 ENSMUST00000021423.7
Noxred1
NADP+ dependent oxidoreductase domain containing 1
chr2_+_79635416 0.014 ENSMUST00000111788.1
Ssfa2
sperm specific antigen 2
chr11_+_78188422 0.010 ENSMUST00000002128.7
ENSMUST00000150941.1
Rab34

RAB34, member of RAS oncogene family


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 7.9 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
1.6 11.4 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
1.1 3.2 GO:1902524 interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of protein K48-linked ubiquitination(GO:1902524)
1.0 4.8 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
0.8 3.9 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
0.5 3.2 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.5 3.9 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.5 4.9 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.5 2.4 GO:0042364 water-soluble vitamin biosynthetic process(GO:0042364)
0.4 1.5 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.4 1.5 GO:0006526 arginine biosynthetic process(GO:0006526)
0.3 2.2 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.3 0.9 GO:0006106 fumarate metabolic process(GO:0006106)
0.3 0.9 GO:0086053 renin secretion into blood stream(GO:0002001) cell communication by chemical coupling(GO:0010643) AV node cell to bundle of His cell communication by electrical coupling(GO:0086053) regulation of renin secretion into blood stream(GO:1900133)
0.3 2.4 GO:0071493 cellular response to UV-B(GO:0071493)
0.3 1.0 GO:2000383 regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384)
0.2 1.0 GO:2000484 response to diacyl bacterial lipopeptide(GO:0071724) cellular response to diacyl bacterial lipopeptide(GO:0071726) positive regulation of interleukin-8 secretion(GO:2000484)
0.2 0.7 GO:0045658 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
0.2 0.5 GO:0001757 somite specification(GO:0001757)
0.2 6.1 GO:0030903 notochord development(GO:0030903)
0.2 1.9 GO:0043201 response to leucine(GO:0043201) cellular response to leucine(GO:0071233)
0.2 1.6 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.2 2.2 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.2 1.1 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.2 0.6 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.2 7.6 GO:0001937 negative regulation of endothelial cell proliferation(GO:0001937)
0.2 0.8 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.2 0.9 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.2 0.5 GO:0072683 T cell extravasation(GO:0072683)
0.2 0.5 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.1 0.4 GO:1903490 regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490)
0.1 0.4 GO:0001803 antibody-dependent cellular cytotoxicity(GO:0001788) type III hypersensitivity(GO:0001802) regulation of type III hypersensitivity(GO:0001803) positive regulation of type III hypersensitivity(GO:0001805)
0.1 1.5 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.1 5.9 GO:0043029 T cell homeostasis(GO:0043029)
0.1 6.0 GO:0050830 defense response to Gram-positive bacterium(GO:0050830)
0.1 0.4 GO:0006776 vitamin A metabolic process(GO:0006776) positive regulation of skeletal muscle tissue regeneration(GO:0043415)
0.1 4.1 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.1 0.4 GO:0018242 protein O-linked glycosylation via serine(GO:0018242)
0.1 2.0 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.1 1.8 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.1 0.8 GO:0021891 olfactory bulb interneuron development(GO:0021891)
0.1 1.5 GO:0007271 synaptic transmission, cholinergic(GO:0007271)
0.1 0.2 GO:1905077 negative regulation of interleukin-17 secretion(GO:1905077)
0.1 1.3 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.1 1.5 GO:0018345 protein palmitoylation(GO:0018345)
0.1 1.5 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.1 2.2 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.1 0.7 GO:0048642 negative regulation of skeletal muscle tissue development(GO:0048642)
0.1 0.8 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.0 0.6 GO:0043248 proteasome assembly(GO:0043248)
0.0 1.4 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 0.5 GO:0090435 protein localization to nuclear envelope(GO:0090435)
0.0 0.6 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.0 0.2 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.0 1.1 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 1.2 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 1.7 GO:0032543 mitochondrial translation(GO:0032543)
0.0 1.7 GO:0046902 regulation of mitochondrial membrane permeability(GO:0046902)
0.0 0.2 GO:0032346 positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349) leading edge cell differentiation(GO:0035026) regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
0.0 1.2 GO:0033119 negative regulation of RNA splicing(GO:0033119)
0.0 1.5 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0 0.1 GO:0052428 modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
0.0 0.6 GO:0001921 positive regulation of receptor recycling(GO:0001921)
0.0 0.3 GO:0019835 cytolysis(GO:0019835)
0.0 0.8 GO:0097120 receptor localization to synapse(GO:0097120)
0.0 0.3 GO:0042036 negative regulation of cytokine biosynthetic process(GO:0042036)
0.0 3.2 GO:0010631 epithelial cell migration(GO:0010631)
0.0 1.4 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)
0.0 5.7 GO:0030334 regulation of cell migration(GO:0030334)
0.0 0.2 GO:0000338 protein deneddylation(GO:0000338)
0.0 0.9 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 6.8 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.8 2.4 GO:0070557 PCNA-p21 complex(GO:0070557)
0.4 1.9 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.3 4.9 GO:0035686 sperm fibrous sheath(GO:0035686)
0.3 5.3 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.2 11.4 GO:0048786 presynaptic active zone(GO:0048786)
0.2 0.5 GO:0044299 C-fiber(GO:0044299)
0.2 1.0 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 3.9 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 1.0 GO:0045298 tubulin complex(GO:0045298)
0.1 1.6 GO:0098644 complex of collagen trimers(GO:0098644)
0.1 0.3 GO:1990111 spermatoproteasome complex(GO:1990111)
0.1 1.1 GO:0031932 TORC2 complex(GO:0031932)
0.1 0.9 GO:0005922 connexon complex(GO:0005922)
0.1 0.9 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.1 0.4 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.1 0.6 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 1.1 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.6 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 2.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 3.9 GO:0015935 small ribosomal subunit(GO:0015935)
0.0 0.2 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.9 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 1.5 GO:0005801 cis-Golgi network(GO:0005801)
0.0 5.1 GO:0000776 kinetochore(GO:0000776)
0.0 1.7 GO:0000313 organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761)
0.0 1.4 GO:0043209 myelin sheath(GO:0043209)
0.0 0.8 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 2.2 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.9 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 1.3 GO:0005758 mitochondrial intermembrane space(GO:0005758)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 11.4 GO:0004351 glutamate decarboxylase activity(GO:0004351)
1.3 3.9 GO:0030156 benzodiazepine receptor binding(GO:0030156)
0.8 4.9 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.8 3.2 GO:0036468 aromatic-L-amino-acid decarboxylase activity(GO:0004058) L-dopa decarboxylase activity(GO:0036468)
0.8 2.4 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.4 1.5 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.3 2.4 GO:0031419 cobalamin binding(GO:0031419)
0.3 1.0 GO:0071723 lipopeptide binding(GO:0071723)
0.3 0.9 GO:0086077 gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling(GO:0086077)
0.2 2.3 GO:0042301 phosphate ion binding(GO:0042301)
0.2 2.2 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.2 1.5 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.2 1.5 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.2 10.8 GO:0005179 hormone activity(GO:0005179)
0.1 8.4 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 6.0 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 1.1 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.1 3.2 GO:0004697 protein kinase C activity(GO:0004697)
0.1 0.4 GO:0016501 prostacyclin receptor activity(GO:0016501)
0.1 0.5 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.1 1.4 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 4.5 GO:0005504 fatty acid binding(GO:0005504)
0.1 0.4 GO:0051425 PTB domain binding(GO:0051425)
0.1 0.4 GO:0019770 IgG receptor activity(GO:0019770)
0.1 1.0 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.1 0.8 GO:0001972 retinoic acid binding(GO:0001972)
0.1 0.9 GO:0046527 glucosyltransferase activity(GO:0046527)
0.1 1.1 GO:0001056 RNA polymerase III activity(GO:0001056)
0.1 1.5 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.6 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 1.5 GO:0050699 WW domain binding(GO:0050699)
0.0 1.8 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 6.7 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 0.8 GO:0070717 poly-purine tract binding(GO:0070717)
0.0 1.9 GO:0019003 GDP binding(GO:0019003)
0.0 0.2 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 2.2 GO:0032947 protein complex scaffold(GO:0032947)
0.0 0.9 GO:0016836 hydro-lyase activity(GO:0016836)
0.0 6.6 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.9 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.2 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.7 GO:0030332 cyclin binding(GO:0030332)
0.0 1.5 GO:0019905 syntaxin binding(GO:0019905)
0.0 0.8 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 2.0 GO:0017124 SH3 domain binding(GO:0017124)
0.0 1.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.3 GO:0070628 proteasome binding(GO:0070628)
0.0 0.9 GO:0043022 ribosome binding(GO:0043022)
0.0 5.3 GO:0045296 cadherin binding(GO:0045296)
0.0 0.5 GO:0001671 ATPase activator activity(GO:0001671)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.4 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 5.9 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 2.1 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 4.9 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.4 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.0 7.1 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.8 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.0 1.0 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 2.0 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 2.2 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.9 PID_BCR_5PATHWAY BCR signaling pathway
0.0 4.1 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 1.0 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.8 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.0 PID_PLK1_PATHWAY PLK1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 11.4 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.3 5.9 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.3 3.2 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.2 2.2 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.1 11.3 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 11.7 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 1.6 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.1 2.4 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.1 1.0 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.1 2.3 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.1 0.9 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.1 1.4 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.1 1.5 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.1 9.4 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 0.8 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 1.1 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 5.1 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 2.4 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.8 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.0 1.0 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.5 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.9 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 1.5 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.4 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 1.1 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation