Motif ID: Tbx2

Z-value: 0.461


Transcription factors associated with Tbx2:

Gene SymbolEntrez IDGene Name
Tbx2 ENSMUSG00000000093.6 Tbx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tbx2mm10_v2_chr11_+_85832551_85832551-0.241.3e-01Click!


Activity profile for motif Tbx2.

activity profile for motif Tbx2


Sorted Z-values histogram for motif Tbx2

Sorted Z-values for motif Tbx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_26229707 4.066 ENSMUST00000060716.5
ENSMUST00000164660.1
Samd3

sterile alpha motif domain containing 3

chr1_-_138847579 3.474 ENSMUST00000093486.3
ENSMUST00000046870.6
Lhx9

LIM homeobox protein 9

chr7_-_137314394 1.424 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
Ebf3



early B cell factor 3



chr14_+_68083853 1.312 ENSMUST00000022639.7
Nefl
neurofilament, light polypeptide
chr15_+_61987034 1.160 ENSMUST00000159338.1
Myc
myelocytomatosis oncogene
chr1_-_105356658 1.060 ENSMUST00000058688.5
ENSMUST00000172299.1
Rnf152

ring finger protein 152

chr1_+_132316112 0.988 ENSMUST00000082125.5
ENSMUST00000072177.7
Nuak2

NUAK family, SNF1-like kinase, 2

chr2_+_124089961 0.967 ENSMUST00000103241.1
Sema6d
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr1_-_172329261 0.905 ENSMUST00000062387.2
Kcnj9
potassium inwardly-rectifying channel, subfamily J, member 9
chr18_-_62741387 0.881 ENSMUST00000097557.3
Spink13
serine peptidase inhibitor, Kazal type 13
chr5_+_108065742 0.787 ENSMUST00000081567.4
ENSMUST00000170319.1
ENSMUST00000112626.1
Mtf2


metal response element binding transcription factor 2


chr1_-_52500679 0.771 ENSMUST00000069792.7
Nab1
Ngfi-A binding protein 1
chr3_-_158562199 0.752 ENSMUST00000106044.1
Lrrc7
leucine rich repeat containing 7
chr3_+_102734496 0.733 ENSMUST00000029451.5
Tspan2
tetraspanin 2
chr4_+_116221633 0.675 ENSMUST00000030464.7
Pik3r3
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
chr11_-_84068766 0.626 ENSMUST00000018792.5
Dusp14
dual specificity phosphatase 14
chr5_+_108065696 0.613 ENSMUST00000172045.1
Mtf2
metal response element binding transcription factor 2
chr3_-_127499095 0.603 ENSMUST00000182594.1
Ank2
ankyrin 2, brain
chr10_+_96136603 0.599 ENSMUST00000074615.6
Gm5426
predicted pseudogene 5426
chr6_+_15196949 0.589 ENSMUST00000151301.1
ENSMUST00000131414.1
ENSMUST00000140557.1
ENSMUST00000115469.1
Foxp2



forkhead box P2



chr4_+_116221689 0.585 ENSMUST00000106490.2
Pik3r3
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
chr11_-_84068357 0.565 ENSMUST00000100705.4
Dusp14
dual specificity phosphatase 14
chr4_+_94614483 0.558 ENSMUST00000030311.4
ENSMUST00000107104.2
Ift74

intraflagellar transport 74

chr1_+_170214826 0.540 ENSMUST00000159201.1
ENSMUST00000055830.1
4930500M09Rik

RIKEN cDNA 4930500M09 gene

chr4_+_116221590 0.532 ENSMUST00000147292.1
Pik3r3
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
chr2_-_114052804 0.532 ENSMUST00000090269.6
Actc1
actin, alpha, cardiac muscle 1
chr2_+_68861433 0.526 ENSMUST00000028426.2
Cers6
ceramide synthase 6
chr2_+_103970115 0.522 ENSMUST00000111143.1
ENSMUST00000138815.1
Lmo2

LIM domain only 2

chr7_+_29309429 0.475 ENSMUST00000137848.1
Dpf1
D4, zinc and double PHD fingers family 1
chr13_-_43304153 0.474 ENSMUST00000055341.5
Gfod1
glucose-fructose oxidoreductase domain containing 1
chr2_-_103797617 0.455 ENSMUST00000028607.6
Caprin1
cell cycle associated protein 1
chr2_+_52857844 0.452 ENSMUST00000090952.4
ENSMUST00000049483.6
ENSMUST00000050719.6
Fmnl2


formin-like 2


chrX_-_95444789 0.442 ENSMUST00000084535.5
Amer1
APC membrane recruitment 1
chr2_+_68861564 0.440 ENSMUST00000176018.1
Cers6
ceramide synthase 6
chr12_-_41485751 0.421 ENSMUST00000043884.4
Lrrn3
leucine rich repeat protein 3, neuronal
chr3_+_32436376 0.418 ENSMUST00000108242.1
Pik3ca
phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
chr7_-_141443989 0.400 ENSMUST00000026580.5
Lrdd
leucine-rich and death domain containing
chr13_+_93308006 0.397 ENSMUST00000079086.6
Homer1
homer homolog 1 (Drosophila)
chr6_+_50110837 0.396 ENSMUST00000167628.1
Mpp6
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
chr11_-_23895208 0.377 ENSMUST00000102863.2
ENSMUST00000020513.3
Papolg

poly(A) polymerase gamma

chr7_-_28302238 0.370 ENSMUST00000108315.3
Dll3
delta-like 3 (Drosophila)
chr5_-_108132541 0.368 ENSMUST00000119437.1
ENSMUST00000118036.1
Tmed5

transmembrane emp24 protein transport domain containing 5

chr2_+_152081529 0.354 ENSMUST00000064061.3
Scrt2
scratch homolog 2, zinc finger protein (Drosophila)
chr2_-_91182848 0.317 ENSMUST00000111370.2
ENSMUST00000111376.1
ENSMUST00000099723.2
Madd


MAP-kinase activating death domain


chr1_+_63273261 0.313 ENSMUST00000114132.1
ENSMUST00000126932.1
Zdbf2

zinc finger, DBF-type containing 2

chr9_-_48495321 0.310 ENSMUST00000170000.2
Rbm7
RNA binding motif protein 7
chr16_+_19028232 0.308 ENSMUST00000074116.4
Gm10088
predicted gene 10088
chr2_-_91183017 0.302 ENSMUST00000066420.5
Madd
MAP-kinase activating death domain
chr10_+_106470281 0.293 ENSMUST00000029404.9
ENSMUST00000169303.1
Ppfia2

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2

chr1_-_51915968 0.292 ENSMUST00000046390.7
Myo1b
myosin IB
chr9_-_85749308 0.283 ENSMUST00000039213.8
Ibtk
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chrX_+_159840463 0.268 ENSMUST00000112451.1
ENSMUST00000112453.2
Sh3kbp1

SH3-domain kinase binding protein 1

chr15_-_95528228 0.263 ENSMUST00000075275.2
Nell2
NEL-like 2
chr4_+_148000722 0.257 ENSMUST00000103230.4
Nppa
natriuretic peptide type A
chr1_+_152954966 0.252 ENSMUST00000043313.8
Nmnat2
nicotinamide nucleotide adenylyltransferase 2
chr4_-_132510493 0.248 ENSMUST00000030724.8
Sesn2
sestrin 2
chr1_+_131970589 0.244 ENSMUST00000027695.6
Slc45a3
solute carrier family 45, member 3
chr19_-_45046614 0.241 ENSMUST00000145391.1
Pdzd7
PDZ domain containing 7
chr5_+_111733924 0.230 ENSMUST00000180627.1
Gm26897
predicted gene, 26897
chr16_+_23107413 0.225 ENSMUST00000023599.6
ENSMUST00000168891.1
Eif4a2

eukaryotic translation initiation factor 4A2

chr9_+_19641224 0.225 ENSMUST00000079042.6
Zfp317
zinc finger protein 317
chr15_-_81360739 0.219 ENSMUST00000023040.7
Slc25a17
solute carrier family 25 (mitochondrial carrier, peroxisomal membrane protein), member 17
chr17_+_3397189 0.216 ENSMUST00000072156.6
Tiam2
T cell lymphoma invasion and metastasis 2
chr13_+_13590402 0.209 ENSMUST00000110559.1
Lyst
lysosomal trafficking regulator
chr11_-_87826023 0.207 ENSMUST00000103177.3
Lpo
lactoperoxidase
chr7_+_133637686 0.205 ENSMUST00000128901.2
2700050L05Rik
RIKEN cDNA 2700050L05 gene
chr3_-_107943705 0.195 ENSMUST00000106680.1
ENSMUST00000106684.1
ENSMUST00000106685.2
Gstm6


glutathione S-transferase, mu 6


chr15_-_95528702 0.187 ENSMUST00000166170.1
Nell2
NEL-like 2
chr4_+_42950369 0.177 ENSMUST00000084662.5
Dnajb5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr2_+_54436317 0.173 ENSMUST00000112636.1
ENSMUST00000112635.1
ENSMUST00000112634.1
Galnt13


UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13


chr9_+_54980880 0.163 ENSMUST00000093844.3
Chrna5
cholinergic receptor, nicotinic, alpha polypeptide 5
chr19_-_37207293 0.161 ENSMUST00000132580.1
ENSMUST00000079754.4
ENSMUST00000136286.1
ENSMUST00000126188.1
ENSMUST00000126781.1
Cpeb3




cytoplasmic polyadenylation element binding protein 3




chr8_+_106870827 0.160 ENSMUST00000176144.1
ENSMUST00000175987.1
Has3

hyaluronan synthase 3

chrX_+_139210031 0.159 ENSMUST00000113043.1
ENSMUST00000169886.1
ENSMUST00000113045.2
Mum1l1


melanoma associated antigen (mutated) 1-like 1


chr6_+_115134899 0.158 ENSMUST00000009538.5
ENSMUST00000169345.1
Syn2

synapsin II

chr19_+_4003334 0.155 ENSMUST00000025806.3
Doc2g
double C2, gamma
chr13_+_80886095 0.149 ENSMUST00000161441.1
Arrdc3
arrestin domain containing 3
chr13_+_54503779 0.145 ENSMUST00000121401.1
ENSMUST00000118072.1
ENSMUST00000159721.1
Simc1


SUMO-interacting motifs containing 1


chr2_+_164823001 0.132 ENSMUST00000132282.1
Zswim1
zinc finger SWIM-type containing 1
chr4_+_84884366 0.131 ENSMUST00000102819.3
Cntln
centlein, centrosomal protein
chr4_-_129573637 0.129 ENSMUST00000102596.1
Lck
lymphocyte protein tyrosine kinase
chr6_+_116264186 0.127 ENSMUST00000036503.7
ENSMUST00000112900.3
Zfand4

zinc finger, AN1-type domain 4

chr3_+_95499273 0.127 ENSMUST00000015664.3
Ctsk
cathepsin K
chr12_-_31634592 0.118 ENSMUST00000020979.7
ENSMUST00000177962.1
Bcap29

B cell receptor associated protein 29

chr5_-_5514730 0.118 ENSMUST00000115445.1
ENSMUST00000179804.1
ENSMUST00000125110.1
ENSMUST00000115446.1
Cldn12



claudin 12



chr5_-_151190154 0.118 ENSMUST00000062015.8
ENSMUST00000110483.2
Stard13

StAR-related lipid transfer (START) domain containing 13

chr9_+_48495345 0.117 ENSMUST00000048824.7
Gm5617
predicted gene 5617
chr5_-_5514873 0.103 ENSMUST00000060947.7
Cldn12
claudin 12
chr9_-_31464238 0.099 ENSMUST00000048050.7
Tmem45b
transmembrane protein 45b
chrX_-_53269020 0.097 ENSMUST00000114838.1
Fam122b
family with sequence similarity 122, member B
chr1_-_172082757 0.089 ENSMUST00000003550.4
Ncstn
nicastrin
chr14_+_51893610 0.089 ENSMUST00000047726.5
ENSMUST00000161888.1
Slc39a2

solute carrier family 39 (zinc transporter), member 2

chr4_+_84884418 0.083 ENSMUST00000169371.2
Cntln
centlein, centrosomal protein
chr5_-_137533170 0.081 ENSMUST00000168746.1
ENSMUST00000170293.1
Gnb2

guanine nucleotide binding protein (G protein), beta 2

chr1_+_164115264 0.074 ENSMUST00000162746.1
Selp
selectin, platelet
chr7_-_30563184 0.073 ENSMUST00000043898.6
Psenen
presenilin enhancer 2 homolog (C. elegans)
chr19_+_8840519 0.072 ENSMUST00000086058.6
Bscl2
Bernardinelli-Seip congenital lipodystrophy 2 homolog (human)
chr9_-_22131801 0.070 ENSMUST00000069330.6
Acp5
acid phosphatase 5, tartrate resistant
chr9_-_49798729 0.069 ENSMUST00000166811.2
Ncam1
neural cell adhesion molecule 1
chr5_-_137533212 0.061 ENSMUST00000111038.1
ENSMUST00000143495.1
Epo
Gnb2
erythropoietin
guanine nucleotide binding protein (G protein), beta 2
chr7_+_3645267 0.057 ENSMUST00000038913.9
Cnot3
CCR4-NOT transcription complex, subunit 3
chr11_+_58104229 0.056 ENSMUST00000108843.1
ENSMUST00000134896.1
Cnot8

CCR4-NOT transcription complex, subunit 8

chr1_-_10038106 0.054 ENSMUST00000027050.3
Cops5
COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana)
chr9_-_49798905 0.054 ENSMUST00000114476.2
Ncam1
neural cell adhesion molecule 1
chr4_+_42035113 0.045 ENSMUST00000098127.1
Gm10597
predicted gene 10597
chr6_+_42286709 0.037 ENSMUST00000163936.1
Clcn1
chloride channel 1
chr7_+_111028951 0.034 ENSMUST00000005749.5
Ctr9
Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr5_+_32136458 0.034 ENSMUST00000031017.9
Fosl2
fos-like antigen 2
chr4_+_41465134 0.026 ENSMUST00000030154.6
Nudt2
nudix (nucleoside diphosphate linked moiety X)-type motif 2
chr5_+_96209463 0.025 ENSMUST00000117766.1
Mrpl1
mitochondrial ribosomal protein L1
chr11_+_83662579 0.023 ENSMUST00000019074.3
Ccl4
chemokine (C-C motif) ligand 4
chr8_-_105933832 0.021 ENSMUST00000034368.6
Ctrl
chymotrypsin-like
chr19_-_46327121 0.021 ENSMUST00000041391.4
ENSMUST00000096029.5
Psd

pleckstrin and Sec7 domain containing

chr11_+_23306910 0.018 ENSMUST00000137823.1
Usp34
ubiquitin specific peptidase 34
chr18_+_55057557 0.016 ENSMUST00000181765.1
Gm4221
predicted gene 4221
chr11_-_101551837 0.012 ENSMUST00000017290.4
Brca1
breast cancer 1
chr2_+_175469985 0.006 ENSMUST00000109042.3
ENSMUST00000109002.2
ENSMUST00000109043.2
ENSMUST00000143490.1
Gm8923



predicted gene 8923



chr12_-_87775755 0.005 ENSMUST00000164517.2
Gm21319
predicted gene, 21319
chr5_-_108132577 0.002 ENSMUST00000061203.6
ENSMUST00000002837.4
Tmed5

transmembrane emp24 protein transport domain containing 5

chr11_+_23306884 0.001 ENSMUST00000180046.1
Usp34
ubiquitin specific peptidase 34

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 3.5 GO:0035262 gonad morphogenesis(GO:0035262)
0.4 1.3 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.3 1.2 GO:0044330 canonical Wnt signaling pathway involved in positive regulation of wound healing(GO:0044330) lactic acid secretion(GO:0046722) regulation of metanephric cap mesenchymal cell proliferation(GO:0090095) positive regulation of metanephric cap mesenchymal cell proliferation(GO:0090096)
0.3 1.4 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.2 0.6 GO:1902277 negative regulation of pancreatic amylase secretion(GO:1902277)
0.2 0.7 GO:0014005 microglia differentiation(GO:0014004) microglia development(GO:0014005)
0.2 0.9 GO:0060467 negative regulation of fertilization(GO:0060467)
0.1 0.4 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.1 0.5 GO:0030240 skeletal muscle thin filament assembly(GO:0030240)
0.1 0.2 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.1 0.2 GO:0015772 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.1 0.6 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.1 0.4 GO:0007386 compartment pattern specification(GO:0007386)
0.1 0.4 GO:2001012 mesenchymal cell differentiation involved in kidney development(GO:0072161) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.1 1.1 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.1 0.2 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.1 0.2 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 0.6 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.1 0.3 GO:1903764 regulation of potassium ion export across plasma membrane(GO:1903764)
0.1 0.3 GO:0019355 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process(GO:0034627) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.1 0.2 GO:0002182 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.1 0.2 GO:0036118 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.0 0.1 GO:0090327 negative regulation of locomotion involved in locomotory behavior(GO:0090327)
0.0 0.6 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.0 0.2 GO:0015867 ATP transport(GO:0015867)
0.0 0.5 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.0 0.1 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.0 0.5 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.0 0.1 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0 1.4 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.0 1.2 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.9 GO:0010107 potassium ion import(GO:0010107)
0.0 1.0 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.0 0.9 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.4 GO:0048875 chemical homeostasis within a tissue(GO:0048875)
0.0 0.2 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.0 0.1 GO:0046645 positive regulation of gamma-delta T cell differentiation(GO:0045588) positive regulation of gamma-delta T cell activation(GO:0046645)
0.0 0.1 GO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.0 0.8 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 0.2 GO:0035095 behavioral response to nicotine(GO:0035095)
0.0 0.2 GO:0090161 Golgi ribbon formation(GO:0090161)
0.0 0.2 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.0 0.1 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.0 0.0 GO:2001160 regulation of histone H3-K79 methylation(GO:2001160)
0.0 0.2 GO:0007220 Notch receptor processing(GO:0007220)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.1 0.4 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.1 1.8 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 0.2 GO:0002141 stereocilia ankle link(GO:0002141)
0.1 1.4 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.3 GO:0042629 mast cell granule(GO:0042629)
0.0 1.0 GO:0043034 costamere(GO:0043034)
0.0 0.2 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 1.2 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 0.8 GO:0043194 axon initial segment(GO:0043194)
0.0 0.5 GO:0071565 nBAF complex(GO:0071565)
0.0 0.2 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 0.6 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.2 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.1 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.2 GO:0070382 exocytic vesicle(GO:0070382)
0.0 0.2 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.4 GO:0030131 clathrin adaptor complex(GO:0030131)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.8 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.2 0.9 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 1.0 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.1 0.2 GO:0008515 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.1 1.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 0.2 GO:0015228 coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122)
0.1 0.3 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.1 0.3 GO:0004515 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.1 0.4 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.1 0.2 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 0.4 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.1 1.3 GO:0043274 phospholipase binding(GO:0043274)
0.0 1.0 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.1 GO:0042610 CD8 receptor binding(GO:0042610)
0.0 0.2 GO:0070728 leucine binding(GO:0070728)
0.0 0.4 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 1.7 GO:0070888 E-box binding(GO:0070888)
0.0 0.1 GO:0032184 SUMO polymer binding(GO:0032184)
0.0 0.1 GO:0005128 erythropoietin receptor binding(GO:0005128)
0.0 0.3 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 0.3 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.1 GO:0042806 fucose binding(GO:0042806)
0.0 1.4 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.4 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.2 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.6 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.2 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.2 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.6 GO:0030507 spectrin binding(GO:0030507)
0.0 0.6 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 0.4 GO:0005112 Notch binding(GO:0005112)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.2 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.0 1.2 PID_MYC_PATHWAY C-MYC pathway
0.0 0.9 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.3 PID_BCR_5PATHWAY BCR signaling pathway
0.0 0.6 PID_CERAMIDE_PATHWAY Ceramide signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.1 1.3 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 1.0 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 1.2 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 1.0 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 1.0 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.1 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.4 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.2 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.1 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.3 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 0.2 REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 0.2 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.2 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle