Motif ID: Mtf1

Z-value: 1.289


Transcription factors associated with Mtf1:

Gene SymbolEntrez IDGene Name
Mtf1 ENSMUSG00000028890.7 Mtf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mtf1mm10_v2_chr4_+_124802543_124802678-0.038.7e-01Click!


Activity profile for motif Mtf1.

activity profile for motif Mtf1


Sorted Z-values histogram for motif Mtf1

Sorted Z-values for motif Mtf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Mtf1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_+_94172618 45.426 ENSMUST00000034214.6
Mt2
metallothionein 2
chr8_+_94179089 29.275 ENSMUST00000034215.6
Mt1
metallothionein 1
chr11_-_32222233 11.192 ENSMUST00000150381.1
ENSMUST00000144902.1
ENSMUST00000020524.8
Rhbdf1


rhomboid family 1 (Drosophila)


chr17_+_85620816 6.358 ENSMUST00000175898.2
Six3
sine oculis-related homeobox 3
chr11_+_63133068 5.555 ENSMUST00000108700.1
Pmp22
peripheral myelin protein 22
chr11_+_63132569 5.126 ENSMUST00000108701.1
Pmp22
peripheral myelin protein 22
chr13_+_23934434 3.988 ENSMUST00000072391.1
Hist1h2aa
histone cluster 1, H2aa
chr1_+_157412352 3.842 ENSMUST00000061537.5
2810025M15Rik
RIKEN cDNA 2810025M15 gene
chr14_-_26170283 3.709 ENSMUST00000100809.4
Plac9b
placenta specific 9b
chr1_+_135729147 2.811 ENSMUST00000027677.7
Csrp1
cysteine and glycine-rich protein 1
chr2_+_119112793 2.716 ENSMUST00000140939.1
ENSMUST00000028795.3
Rad51

RAD51 homolog

chr4_+_129985098 2.692 ENSMUST00000106017.1
ENSMUST00000121049.1
Bai2

brain-specific angiogenesis inhibitor 2

chr4_+_129984833 2.651 ENSMUST00000120204.1
Bai2
brain-specific angiogenesis inhibitor 2
chr1_-_169531343 2.640 ENSMUST00000028000.7
Nuf2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr1_+_131867224 2.326 ENSMUST00000112386.1
ENSMUST00000027693.7
Rab7l1

RAB7, member RAS oncogene family-like 1

chr1_-_169531447 2.318 ENSMUST00000111368.1
Nuf2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr5_-_125341043 2.143 ENSMUST00000111390.1
ENSMUST00000086075.6
Scarb1

scavenger receptor class B, member 1

chr12_-_4592927 1.919 ENSMUST00000170816.1
Gm3625
predicted gene 3625
chr19_-_4201591 1.845 ENSMUST00000025740.6
Rad9a
RAD9 homolog A
chr9_-_112187898 1.782 ENSMUST00000178410.1
ENSMUST00000172380.3
Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr6_-_39118211 1.730 ENSMUST00000038398.6
Parp12
poly (ADP-ribose) polymerase family, member 12
chr7_+_119793987 1.688 ENSMUST00000033218.8
ENSMUST00000106520.1
2610020H08Rik

RIKEN cDNA 2610020H08 gene

chr4_+_103619580 1.534 ENSMUST00000106827.1
Dab1
disabled 1
chr7_+_119794102 1.515 ENSMUST00000084644.2
2610020H08Rik
RIKEN cDNA 2610020H08 gene
chr1_+_167618246 1.487 ENSMUST00000111380.1
Rxrg
retinoid X receptor gamma
chr7_+_5056856 1.348 ENSMUST00000131368.1
ENSMUST00000123956.1
Ccdc106

coiled-coil domain containing 106

chr18_+_14424821 1.314 ENSMUST00000069552.5
Gm5160
predicted gene 5160
chr6_+_145746739 1.230 ENSMUST00000111704.1
Rassf8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr1_+_75400070 1.217 ENSMUST00000113589.1
Speg
SPEG complex locus
chr3_+_107895821 1.146 ENSMUST00000004134.4
Gstm5
glutathione S-transferase, mu 5
chr17_-_56626872 1.080 ENSMUST00000047226.8
Lonp1
lon peptidase 1, mitochondrial
chr3_+_107895916 1.044 ENSMUST00000172247.1
ENSMUST00000167387.1
Gstm5

glutathione S-transferase, mu 5

chr2_-_130664565 1.032 ENSMUST00000089559.4
Ddrgk1
DDRGK domain containing 1
chr3_-_94412883 0.951 ENSMUST00000181305.1
1700040D17Rik
RIKEN cDNA 1700040D17 gene
chr19_-_4839286 0.904 ENSMUST00000037246.5
Ccs
copper chaperone for superoxide dismutase
chr12_+_103532435 0.814 ENSMUST00000021631.5
Ppp4r4
protein phosphatase 4, regulatory subunit 4
chr1_-_166309585 0.710 ENSMUST00000168347.1
5330438I03Rik
RIKEN cDNA 5330438I03 gene
chr7_+_132610620 0.699 ENSMUST00000033241.5
Lhpp
phospholysine phosphohistidine inorganic pyrophosphate phosphatase
chr8_-_70776650 0.635 ENSMUST00000034296.8
Pik3r2
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta)
chr9_-_14381242 0.626 ENSMUST00000167549.1
Endod1
endonuclease domain containing 1
chr9_+_78175898 0.619 ENSMUST00000180974.1
C920006O11Rik
RIKEN cDNA C920006O11 gene
chr8_+_106210936 0.605 ENSMUST00000071592.5
Prmt7
protein arginine N-methyltransferase 7
chr9_+_109832998 0.605 ENSMUST00000119376.1
ENSMUST00000122343.1
Nme6

NME/NM23 nucleoside diphosphate kinase 6

chr10_+_77606217 0.601 ENSMUST00000129492.1
ENSMUST00000141228.2
Sumo3

SMT3 suppressor of mif two 3 homolog 3 (yeast)

chr3_+_107896247 0.574 ENSMUST00000169365.1
Gstm5
glutathione S-transferase, mu 5
chr16_+_18348181 0.515 ENSMUST00000115614.2
ENSMUST00000115613.1
ENSMUST00000090103.3
Arvcf


armadillo repeat gene deleted in velo-cardio-facial syndrome


chr17_-_83631892 0.500 ENSMUST00000051482.1
Kcng3
potassium voltage-gated channel, subfamily G, member 3
chr5_-_99978914 0.492 ENSMUST00000112939.3
ENSMUST00000171786.1
ENSMUST00000072750.6
ENSMUST00000019128.8
ENSMUST00000172361.1
Hnrnpd




heterogeneous nuclear ribonucleoprotein D




chr19_-_4615647 0.413 ENSMUST00000113822.2
Lrfn4
leucine rich repeat and fibronectin type III domain containing 4
chr11_+_99047311 0.412 ENSMUST00000140772.1
Igfbp4
insulin-like growth factor binding protein 4
chr4_+_134496996 0.387 ENSMUST00000095074.3
Paqr7
progestin and adipoQ receptor family member VII
chr19_-_4615453 0.378 ENSMUST00000053597.2
Lrfn4
leucine rich repeat and fibronectin type III domain containing 4
chr2_+_31759932 0.374 ENSMUST00000028190.6
Abl1
c-abl oncogene 1, non-receptor tyrosine kinase
chr4_+_133574728 0.371 ENSMUST00000030662.2
Gpatch3
G patch domain containing 3
chr12_+_33957645 0.368 ENSMUST00000049089.5
Twist1
twist basic helix-loop-helix transcription factor 1
chr10_-_39899238 0.348 ENSMUST00000178563.1
AA474331
expressed sequence AA474331
chr10_+_77606044 0.343 ENSMUST00000020501.8
Sumo3
SMT3 suppressor of mif two 3 homolog 3 (yeast)
chr5_-_34637203 0.337 ENSMUST00000114331.3
Mfsd10
major facilitator superfamily domain containing 10
chr13_-_45964964 0.336 ENSMUST00000180110.1
ENSMUST00000091628.3
ENSMUST00000167708.2
Atxn1


ataxin 1


chr8_+_106211016 0.328 ENSMUST00000109297.1
Prmt7
protein arginine N-methyltransferase 7
chr17_-_56716788 0.314 ENSMUST00000067931.5
Vmac
vimentin-type intermediate filament associated coiled-coil protein
chr10_+_70245083 0.292 ENSMUST00000046807.6
Slc16a9
solute carrier family 16 (monocarboxylic acid transporters), member 9
chr2_-_119787504 0.283 ENSMUST00000110793.1
ENSMUST00000099529.2
ENSMUST00000048493.5
Rpap1


RNA polymerase II associated protein 1


chr8_+_13159135 0.281 ENSMUST00000033824.6
Lamp1
lysosomal-associated membrane protein 1
chr5_+_115506668 0.265 ENSMUST00000067268.8
ENSMUST00000086523.3
Pxn

paxillin

chr3_-_121815212 0.263 ENSMUST00000029770.5
Abcd3
ATP-binding cassette, sub-family D (ALD), member 3
chr8_-_106210924 0.179 ENSMUST00000035925.5
Slc7a6os
solute carrier family 7, member 6 opposite strand
chr2_+_150323702 0.179 ENSMUST00000133235.2
Gm10130
predicted gene 10130
chr5_-_34637107 0.161 ENSMUST00000124668.1
ENSMUST00000001109.4
ENSMUST00000155577.1
ENSMUST00000114329.1
Mfsd10



major facilitator superfamily domain containing 10



chr2_+_29889720 0.147 ENSMUST00000113767.1
Odf2
outer dense fiber of sperm tails 2
chr1_-_166002591 0.145 ENSMUST00000111429.4
ENSMUST00000176800.1
Pou2f1

POU domain, class 2, transcription factor 1

chr1_-_166002613 0.080 ENSMUST00000177358.1
ENSMUST00000160908.1
ENSMUST00000027850.8
ENSMUST00000160260.2
Pou2f1



POU domain, class 2, transcription factor 1



chr8_+_70905970 0.054 ENSMUST00000019405.2
Map1s
microtubule-associated protein 1S
chr15_-_83149307 0.052 ENSMUST00000100375.4
Poldip3
polymerase (DNA-directed), delta interacting protein 3
chr2_+_29889785 0.045 ENSMUST00000113763.1
ENSMUST00000113757.1
ENSMUST00000113756.1
ENSMUST00000133233.1
ENSMUST00000113759.2
ENSMUST00000113755.1
ENSMUST00000137558.1
ENSMUST00000046571.7
Odf2







outer dense fiber of sperm tails 2







chr5_+_30869579 0.029 ENSMUST00000046349.7
Tmem214
transmembrane protein 214
chr5_+_30869623 0.012 ENSMUST00000114716.1
Tmem214
transmembrane protein 214

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
10.7 74.7 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
2.1 6.4 GO:0097402 neuroblast migration(GO:0097402)
0.9 2.7 GO:0051105 regulation of DNA ligation(GO:0051105) positive regulation of DNA ligation(GO:0051106)
0.7 2.1 GO:0015920 regulation of phosphatidylcholine catabolic process(GO:0010899) lipopolysaccharide transport(GO:0015920)
0.5 10.7 GO:0032060 bleb assembly(GO:0032060)
0.5 1.5 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.4 1.2 GO:0034334 adherens junction maintenance(GO:0034334)
0.4 2.8 GO:0070458 detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458)
0.2 0.9 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.2 1.0 GO:1990564 regulation of I-kappaB phosphorylation(GO:1903719) positive regulation of I-kappaB phosphorylation(GO:1903721) protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.2 0.5 GO:1901355 response to rapamycin(GO:1901355)
0.2 11.2 GO:0042058 regulation of epidermal growth factor receptor signaling pathway(GO:0042058)
0.1 1.8 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.1 5.0 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.1 0.4 GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359) regulation of oxidative phosphorylation uncoupler activity(GO:2000275) cell proliferation involved in heart valve development(GO:2000793)
0.1 0.5 GO:0042891 antibiotic transport(GO:0042891)
0.1 0.3 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626) positive regulation of natural killer cell degranulation(GO:0043323)
0.1 0.3 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.1 0.6 GO:0006228 UTP biosynthetic process(GO:0006228)
0.0 0.3 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 0.4 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.0 0.8 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0 1.5 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 2.8 GO:0070527 platelet aggregation(GO:0070527)
0.0 0.3 GO:0046415 urate metabolic process(GO:0046415)
0.0 4.0 GO:0006342 chromatin silencing(GO:0006342)
0.0 1.8 GO:0034605 cellular response to heat(GO:0034605)
0.0 1.1 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.0 0.2 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.0 1.0 GO:0051353 positive regulation of oxidoreductase activity(GO:0051353)
0.0 0.5 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.5 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.0 0.6 GO:0042993 positive regulation of transcription factor import into nucleus(GO:0042993)
0.0 0.3 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.0 1.2 GO:0055013 cardiac muscle cell development(GO:0055013)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 5.0 GO:0031262 Ndc80 complex(GO:0031262)
0.4 10.7 GO:0043218 compact myelin(GO:0043218)
0.3 1.8 GO:0030896 checkpoint clamp complex(GO:0030896)
0.2 2.8 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 2.7 GO:0000800 lateral element(GO:0000800)
0.1 2.1 GO:0031528 microvillus membrane(GO:0031528)
0.1 0.3 GO:0044194 cytolytic granule(GO:0044194)
0.1 0.3 GO:0045098 type III intermediate filament(GO:0045098)
0.1 27.8 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 10.4 GO:0000139 Golgi membrane(GO:0000139)
0.0 0.6 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.3 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 1.1 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 2.0 GO:0005903 brush border(GO:0005903)
0.0 0.8 GO:0008287 protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293)
0.0 0.2 GO:0097539 ciliary transition fiber(GO:0097539)
0.0 0.3 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.6 30.2 GO:0005507 copper ion binding(GO:0005507)
0.5 1.8 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.4 2.7 GO:0000150 recombinase activity(GO:0000150)
0.3 1.1 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.3 6.4 GO:0001222 transcription corepressor binding(GO:0001222)
0.2 0.9 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.2 0.7 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.1 1.5 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 11.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 2.8 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.1 0.5 GO:0042895 antibiotic transporter activity(GO:0042895)
0.1 0.6 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1 1.7 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 0.5 GO:0031386 protein tag(GO:0031386)
0.1 41.2 GO:0008270 zinc ion binding(GO:0008270)
0.1 0.3 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 0.3 GO:0034046 poly(G) binding(GO:0034046)
0.0 1.6 GO:0042169 SH2 domain binding(GO:0042169)
0.0 0.4 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 0.5 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.6 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.3 GO:0019215 intermediate filament binding(GO:0019215)
0.0 0.5 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 1.0 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.3 GO:0017166 vinculin binding(GO:0017166)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 12.2 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.1 4.6 PID_ATR_PATHWAY ATR signaling pathway
0.0 1.6 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.6 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.0 0.4 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.3 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.1 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.2 2.7 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 1.8 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.1 0.6 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 1.8 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS Genes involved in Activation of ATR in response to replication stress
0.0 5.0 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 1.5 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.3 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.5 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels