Motif ID: Hoxa1

Z-value: 1.041


Transcription factors associated with Hoxa1:

Gene SymbolEntrez IDGene Name
Hoxa1 ENSMUSG00000029844.9 Hoxa1



Activity profile for motif Hoxa1.

activity profile for motif Hoxa1


Sorted Z-values histogram for motif Hoxa1

Sorted Z-values for motif Hoxa1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_143299498 9.989 ENSMUST00000030317.7
Pdpn
podoplanin
chr2_+_163225363 6.152 ENSMUST00000099110.3
ENSMUST00000165937.1
Tox2

TOX high mobility group box family member 2

chr7_+_73391160 5.213 ENSMUST00000128471.1
Rgma
RGM domain family, member A
chr14_+_70077375 4.783 ENSMUST00000035908.1
Egr3
early growth response 3
chr9_+_15239045 4.515 ENSMUST00000034413.6
Vstm5
V-set and transmembrane domain containing 5
chr14_-_103844173 3.960 ENSMUST00000022718.3
Ednrb
endothelin receptor type B
chr4_-_143299463 3.886 ENSMUST00000119654.1
Pdpn
podoplanin
chr3_+_55782500 3.807 ENSMUST00000075422.4
Mab21l1
mab-21-like 1 (C. elegans)
chr19_-_41743665 3.782 ENSMUST00000025993.3
Slit1
slit homolog 1 (Drosophila)
chr9_-_96862903 3.532 ENSMUST00000121077.1
ENSMUST00000124923.1
Acpl2

acid phosphatase-like 2

chr2_+_158375638 2.844 ENSMUST00000109488.1
Snhg11
small nucleolar RNA host gene 11
chr2_-_26246707 2.761 ENSMUST00000166349.1
C030048H21Rik
RIKEN cDNA C030048H21 gene
chr15_-_95528702 2.655 ENSMUST00000166170.1
Nell2
NEL-like 2
chr13_-_60177357 2.655 ENSMUST00000065086.4
Gas1
growth arrest specific 1
chr2_+_152962485 2.645 ENSMUST00000099197.2
ENSMUST00000103155.3
Ttll9

tubulin tyrosine ligase-like family, member 9

chr3_-_110143937 2.621 ENSMUST00000051253.3
Ntng1
netrin G1
chr1_+_153665274 2.584 ENSMUST00000152114.1
ENSMUST00000111812.1
Rgs8

regulator of G-protein signaling 8

chr10_+_26078255 2.211 ENSMUST00000041011.3
Gm9767
predicted gene 9767
chr15_+_98167806 2.010 ENSMUST00000031914.4
AI836003
expressed sequence AI836003
chr5_+_27261916 1.984 ENSMUST00000101471.3
Dpp6
dipeptidylpeptidase 6
chr2_+_65845833 1.819 ENSMUST00000053910.3
Csrnp3
cysteine-serine-rich nuclear protein 3
chr2_+_165595009 1.787 ENSMUST00000088132.6
Eya2
eyes absent 2 homolog (Drosophila)
chr2_+_65845767 1.756 ENSMUST00000122912.1
Csrnp3
cysteine-serine-rich nuclear protein 3
chr9_+_65890237 1.741 ENSMUST00000045802.6
2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr4_-_35845204 1.711 ENSMUST00000164772.1
ENSMUST00000065173.2
Lingo2

leucine rich repeat and Ig domain containing 2

chr12_+_53248677 1.694 ENSMUST00000101432.2
Npas3
neuronal PAS domain protein 3
chr7_-_30534180 1.661 ENSMUST00000044338.4
Arhgap33
Rho GTPase activating protein 33
chr13_-_12340723 1.642 ENSMUST00000168193.1
ENSMUST00000110616.1
ENSMUST00000064204.7
Actn2


actinin alpha 2


chr10_-_63421739 1.624 ENSMUST00000054760.4
Gm7075
predicted gene 7075
chr4_-_106799779 1.485 ENSMUST00000145061.1
ENSMUST00000102762.3
Acot11

acyl-CoA thioesterase 11

chr18_+_4994600 1.456 ENSMUST00000140448.1
Svil
supervillin
chr10_+_94576254 1.415 ENSMUST00000117929.1
Tmcc3
transmembrane and coiled coil domains 3
chr6_-_52012476 1.413 ENSMUST00000078214.5
Skap2
src family associated phosphoprotein 2
chrX_+_110814390 1.279 ENSMUST00000078229.3
Pou3f4
POU domain, class 3, transcription factor 4
chr15_+_74516196 1.162 ENSMUST00000042035.9
Bai1
brain-specific angiogenesis inhibitor 1
chr2_+_90885860 1.154 ENSMUST00000111466.2
C1qtnf4
C1q and tumor necrosis factor related protein 4
chr7_+_144838590 1.147 ENSMUST00000105898.1
Fgf3
fibroblast growth factor 3
chr9_-_4796218 1.140 ENSMUST00000027020.6
ENSMUST00000063508.7
ENSMUST00000163309.1
Gria4


glutamate receptor, ionotropic, AMPA4 (alpha 4)


chr7_-_16917184 1.062 ENSMUST00000173139.1
Calm3
calmodulin 3
chr8_-_8639363 0.991 ENSMUST00000152698.1
Efnb2
ephrin B2
chr9_-_21312255 0.955 ENSMUST00000115433.3
ENSMUST00000003397.7
Ap1m2

adaptor protein complex AP-1, mu 2 subunit

chr17_+_55445375 0.851 ENSMUST00000133899.1
ENSMUST00000086878.3
St6gal2

beta galactoside alpha 2,6 sialyltransferase 2

chr10_+_81628702 0.822 ENSMUST00000129622.1
Ankrd24
ankyrin repeat domain 24
chr3_-_89093358 0.724 ENSMUST00000090929.5
ENSMUST00000052539.6
Rusc1

RUN and SH3 domain containing 1

chr4_+_101507947 0.605 ENSMUST00000149047.1
ENSMUST00000106929.3
Dnajc6

DnaJ (Hsp40) homolog, subfamily C, member 6

chr4_+_101507855 0.593 ENSMUST00000038207.5
Dnajc6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr17_-_25081138 0.552 ENSMUST00000024984.6
Tmem204
transmembrane protein 204
chr17_-_28622419 0.549 ENSMUST00000114767.1
Srpk1
serine/arginine-rich protein specific kinase 1
chr5_+_137030275 0.536 ENSMUST00000041543.8
Vgf
VGF nerve growth factor inducible
chr3_+_98013503 0.514 ENSMUST00000079812.6
Notch2
notch 2
chr9_+_59589288 0.488 ENSMUST00000121266.1
ENSMUST00000118164.1
Celf6

CUGBP, Elav-like family member 6

chr10_+_14523062 0.480 ENSMUST00000096020.5
Gm10335
predicted gene 10335
chr14_+_66344369 0.478 ENSMUST00000118426.1
ENSMUST00000121955.1
ENSMUST00000120229.1
ENSMUST00000134440.1
Stmn4



stathmin-like 4



chr13_+_72628802 0.418 ENSMUST00000074372.4
Irx2
Iroquois related homeobox 2 (Drosophila)
chr10_-_92162753 0.404 ENSMUST00000182197.1
Rmst
rhabdomyosarcoma 2 associated transcript (non-coding RNA)
chr8_+_95825353 0.398 ENSMUST00000074053.4
Gm10094
predicted gene 10094
chr1_+_89454769 0.382 ENSMUST00000027521.8
ENSMUST00000074945.5
Agap1

ArfGAP with GTPase domain, ankyrin repeat and PH domain 1

chr5_+_88583527 0.367 ENSMUST00000031229.6
Rufy3
RUN and FYVE domain containing 3
chr12_-_80260356 0.361 ENSMUST00000021554.8
Actn1
actinin, alpha 1
chr6_-_88446491 0.337 ENSMUST00000165242.1
Eefsec
eukaryotic elongation factor, selenocysteine-tRNA-specific
chr14_+_66344296 0.321 ENSMUST00000152093.1
ENSMUST00000074523.6
Stmn4

stathmin-like 4

chr3_+_68572245 0.310 ENSMUST00000170788.2
Schip1
schwannomin interacting protein 1
chr5_-_135573036 0.280 ENSMUST00000004936.6
Ccl24
chemokine (C-C motif) ligand 24
chr3_-_58525867 0.276 ENSMUST00000029385.7
Serp1
stress-associated endoplasmic reticulum protein 1
chr16_+_38902305 0.257 ENSMUST00000023478.7
Igsf11
immunoglobulin superfamily, member 11
chr7_+_119690026 0.254 ENSMUST00000047045.8
Acsm4
acyl-CoA synthetase medium-chain family member 4
chr4_+_128688726 0.237 ENSMUST00000106080.1
Phc2
polyhomeotic-like 2 (Drosophila)
chr11_+_103774150 0.231 ENSMUST00000000127.5
Wnt3
wingless-related MMTV integration site 3
chr8_-_67515606 0.199 ENSMUST00000032981.5
Gm9755
predicted pseudogene 9755
chr6_-_21851914 0.170 ENSMUST00000134635.1
ENSMUST00000123116.1
ENSMUST00000120965.1
Tspan12


tetraspanin 12


chr17_+_70522149 0.168 ENSMUST00000140728.1
Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr16_-_18876522 0.164 ENSMUST00000119273.1
Mrpl40
mitochondrial ribosomal protein L40
chr18_+_56562443 0.157 ENSMUST00000130163.1
ENSMUST00000132628.1
Phax

phosphorylated adaptor for RNA export

chr11_+_24080664 0.154 ENSMUST00000118955.1
Bcl11a
B cell CLL/lymphoma 11A (zinc finger protein)
chr2_-_152951688 0.152 ENSMUST00000109811.3
Dusp15
dual specificity phosphatase-like 15
chr14_-_69503316 0.135 ENSMUST00000179116.2
Gm21464
predicted gene, 21464
chr17_+_70522083 0.124 ENSMUST00000148486.1
ENSMUST00000133717.1
Dlgap1

discs, large (Drosophila) homolog-associated protein 1

chr17_-_28622479 0.097 ENSMUST00000130643.1
Srpk1
serine/arginine-rich protein specific kinase 1
chr5_+_135369942 0.063 ENSMUST00000000940.8
Nsun5
NOL1/NOP2/Sun domain family, member 5
chr6_+_91684061 0.056 ENSMUST00000032185.7
Slc6a6
solute carrier family 6 (neurotransmitter transporter, taurine), member 6
chr11_-_5898771 0.048 ENSMUST00000102921.3
Myl7
myosin, light polypeptide 7, regulatory
chr2_+_112261926 0.036 ENSMUST00000028553.3
Nop10
NOP10 ribonucleoprotein
chr10_+_79988584 0.029 ENSMUST00000004784.4
ENSMUST00000105374.1
Cnn2

calponin 2

chr11_-_102296618 0.022 ENSMUST00000107132.2
ENSMUST00000073234.2
Atxn7l3

ataxin 7-like 3

chr16_-_18876655 0.014 ENSMUST00000023391.8
Mrpl40
mitochondrial ribosomal protein L40
chr9_+_58129476 0.008 ENSMUST00000133287.1
Stra6
stimulated by retinoic acid gene 6
chr10_+_75037291 0.004 ENSMUST00000139384.1
Rab36
RAB36, member RAS oncogene family

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 13.9 GO:1901731 positive regulation of platelet aggregation(GO:1901731)
1.3 4.0 GO:0014826 vein smooth muscle contraction(GO:0014826)
0.5 3.8 GO:0033563 dorsal/ventral axon guidance(GO:0033563)
0.4 5.2 GO:1900121 negative regulation of receptor binding(GO:1900121)
0.4 1.6 GO:2001137 positive regulation of endocytic recycling(GO:2001137)
0.4 4.8 GO:0033089 positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.3 0.5 GO:0035622 intrahepatic bile duct development(GO:0035622)
0.2 1.7 GO:0016576 histone dephosphorylation(GO:0016576)
0.2 2.7 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.2 2.7 GO:0042473 outer ear morphogenesis(GO:0042473)
0.2 1.1 GO:0030916 otic vesicle formation(GO:0030916)
0.2 1.2 GO:0072318 clathrin coat disassembly(GO:0072318)
0.2 2.6 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.2 1.3 GO:2001054 negative regulation of mesenchymal cell apoptotic process(GO:2001054)
0.1 0.3 GO:2000418 positive regulation of eosinophil migration(GO:2000418)
0.1 1.0 GO:1903847 regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.1 0.4 GO:0072272 proximal/distal pattern formation involved in metanephric nephron development(GO:0072272)
0.1 1.7 GO:0042711 maternal behavior(GO:0042711)
0.1 0.2 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.1 0.5 GO:0043084 penile erection(GO:0043084)
0.1 0.2 GO:0051030 snRNA transport(GO:0051030)
0.0 0.9 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.0 3.6 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.3 GO:0006451 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0 2.0 GO:1901381 positive regulation of potassium ion transmembrane transport(GO:1901381)
0.0 1.5 GO:0009409 response to cold(GO:0009409)
0.0 0.2 GO:1904800 regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800)
0.0 1.0 GO:0051968 positive regulation of synaptic transmission, glutamatergic(GO:0051968)
0.0 0.3 GO:0060124 positive regulation of growth hormone secretion(GO:0060124)
0.0 0.5 GO:0071625 vocalization behavior(GO:0071625)
0.0 0.4 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.3 GO:0070842 aggresome assembly(GO:0070842)
0.0 0.4 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 0.6 GO:0045070 positive regulation of viral genome replication(GO:0045070)
0.0 1.7 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.3 GO:0001553 luteinization(GO:0001553)
0.0 0.6 GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030947)
0.0 0.8 GO:0007019 microtubule depolymerization(GO:0007019)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 13.9 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.2 1.1 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.2 5.3 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 0.4 GO:0032127 dense core granule membrane(GO:0032127)
0.1 2.6 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 1.6 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 3.0 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 3.3 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.4 GO:0071437 invadopodium(GO:0071437)
0.0 1.5 GO:0043034 costamere(GO:0043034)
0.0 1.0 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 2.7 GO:0043204 perikaryon(GO:0043204)
0.0 3.8 GO:0031965 nuclear membrane(GO:0031965)
0.0 0.2 GO:0035102 PRC1 complex(GO:0035102)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 4.0 GO:0004962 endothelin receptor activity(GO:0004962)
1.3 13.9 GO:0015250 water channel activity(GO:0015250)
0.5 3.8 GO:0048495 Roundabout binding(GO:0048495)
0.4 5.2 GO:1990459 transferrin receptor binding(GO:1990459)
0.3 1.1 GO:0031800 type 3 metabotropic glutamate receptor binding(GO:0031800)
0.2 1.6 GO:0031432 thyroid hormone receptor coactivator activity(GO:0030375) titin binding(GO:0031432)
0.2 0.9 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.2 1.1 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 0.3 GO:0003996 acyl-CoA ligase activity(GO:0003996)
0.1 1.3 GO:0003680 AT DNA binding(GO:0003680)
0.1 1.5 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.1 2.6 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 1.1 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.3 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
0.0 1.4 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 6.2 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 2.7 GO:0005080 protein kinase C binding(GO:0005080)
0.0 2.0 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 0.5 GO:0048018 receptor agonist activity(GO:0048018)
0.0 3.8 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.0 0.5 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 3.1 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.4 GO:0017166 vinculin binding(GO:0017166)
0.0 0.5 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 0.2 GO:0015643 toxic substance binding(GO:0015643)
0.0 1.2 GO:0005125 cytokine activity(GO:0005125)
0.0 2.1 GO:0016874 ligase activity(GO:0016874)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.2 PID_BMP_PATHWAY BMP receptor signaling
0.1 4.8 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 3.8 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 2.7 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 4.0 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 1.6 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 1.0 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.7 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 1.5 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 0.4 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 1.3 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1 9.0 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 1.4 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 2.7 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 1.1 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.1 1.0 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 1.2 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 4.0 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.5 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 2.6 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.0 0.4 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions