Motif ID: Smad3
Z-value: 0.742

Transcription factors associated with Smad3:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Smad3 | ENSMUSG00000032402.6 | Smad3 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Smad3 | mm10_v2_chr9_-_63757933_63757994 | 0.66 | 2.2e-06 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.6 | 7.7 | GO:0090274 | positive regulation of somatostatin secretion(GO:0090274) |
1.0 | 18.6 | GO:0045653 | negative regulation of megakaryocyte differentiation(GO:0045653) |
0.8 | 2.3 | GO:0002314 | germinal center B cell differentiation(GO:0002314) positive regulation of germinal center formation(GO:0002636) adenosine catabolic process(GO:0006154) purine nucleobase salvage(GO:0043096) hypoxanthine metabolic process(GO:0046100) hypoxanthine biosynthetic process(GO:0046101) xanthine metabolic process(GO:0046110) purine deoxyribonucleoside metabolic process(GO:0046122) regulation of adenosine receptor signaling pathway(GO:0060167) |
0.5 | 1.4 | GO:2000659 | regulation of interleukin-1-mediated signaling pathway(GO:2000659) |
0.4 | 1.8 | GO:0046655 | glycine biosynthetic process(GO:0006545) folic acid metabolic process(GO:0046655) |
0.4 | 4.2 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
0.3 | 1.2 | GO:0014005 | microglia differentiation(GO:0014004) microglia development(GO:0014005) |
0.3 | 1.4 | GO:0052428 | modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428) |
0.2 | 0.7 | GO:0001180 | transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript(GO:0001180) |
0.2 | 0.5 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
0.2 | 2.7 | GO:0045603 | positive regulation of endothelial cell differentiation(GO:0045603) |
0.1 | 1.0 | GO:0097428 | protein maturation by iron-sulfur cluster transfer(GO:0097428) |
0.1 | 13.8 | GO:0006342 | chromatin silencing(GO:0006342) |
0.1 | 0.9 | GO:0045048 | protein insertion into ER membrane(GO:0045048) |
0.1 | 0.5 | GO:0072697 | protein localization to cell cortex(GO:0072697) |
0.0 | 4.6 | GO:0006334 | nucleosome assembly(GO:0006334) |
0.0 | 0.5 | GO:0019321 | pentose metabolic process(GO:0019321) |
0.0 | 0.2 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
0.0 | 0.3 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
0.0 | 0.9 | GO:0010763 | positive regulation of fibroblast migration(GO:0010763) |
0.0 | 0.4 | GO:0001711 | endodermal cell fate commitment(GO:0001711) |
0.0 | 1.4 | GO:0035082 | axoneme assembly(GO:0035082) |
0.0 | 1.0 | GO:0006182 | cGMP biosynthetic process(GO:0006182) |
0.0 | 1.2 | GO:0071300 | cellular response to retinoic acid(GO:0071300) |
0.0 | 2.8 | GO:0031110 | regulation of microtubule polymerization or depolymerization(GO:0031110) |
0.0 | 0.6 | GO:0051894 | positive regulation of focal adhesion assembly(GO:0051894) |
0.0 | 0.1 | GO:0010908 | regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) |
0.0 | 0.4 | GO:0043949 | regulation of cAMP-mediated signaling(GO:0043949) |
0.0 | 0.2 | GO:0048643 | locomotor rhythm(GO:0045475) positive regulation of skeletal muscle tissue development(GO:0048643) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 1.4 | GO:1990667 | PCSK9-AnxA2 complex(GO:1990667) |
0.4 | 14.1 | GO:0000788 | nuclear nucleosome(GO:0000788) |
0.4 | 14.1 | GO:0000786 | nucleosome(GO:0000786) |
0.2 | 2.8 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
0.2 | 1.6 | GO:0001520 | outer dense fiber(GO:0001520) |
0.1 | 1.0 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
0.1 | 1.9 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
0.0 | 6.6 | GO:0043195 | terminal bouton(GO:0043195) |
0.0 | 0.4 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
0.0 | 0.7 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
0.0 | 1.7 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
0.0 | 0.3 | GO:0005614 | interstitial matrix(GO:0005614) |
0.0 | 0.2 | GO:0030056 | hemidesmosome(GO:0030056) |
0.0 | 6.6 | GO:0000790 | nuclear chromatin(GO:0000790) |
0.0 | 5.4 | GO:0005874 | microtubule(GO:0005874) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.8 | 5.9 | GO:0008568 | microtubule-severing ATPase activity(GO:0008568) |
0.6 | 1.8 | GO:0051870 | methotrexate binding(GO:0051870) |
0.3 | 1.4 | GO:0004859 | phospholipase inhibitor activity(GO:0004859) phospholipase A2 inhibitor activity(GO:0019834) |
0.2 | 2.3 | GO:0004000 | adenosine deaminase activity(GO:0004000) |
0.1 | 7.7 | GO:0008528 | G-protein coupled peptide receptor activity(GO:0008528) |
0.1 | 0.7 | GO:0001179 | RNA polymerase I transcription factor binding(GO:0001179) |
0.1 | 17.5 | GO:0042393 | histone binding(GO:0042393) |
0.1 | 2.7 | GO:0070888 | E-box binding(GO:0070888) |
0.1 | 1.0 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
0.0 | 1.0 | GO:0015035 | protein disulfide oxidoreductase activity(GO:0015035) |
0.0 | 0.9 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
0.0 | 0.5 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
0.0 | 0.5 | GO:0019200 | carbohydrate kinase activity(GO:0019200) |
0.0 | 0.4 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
0.0 | 0.6 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
0.0 | 0.5 | GO:0004601 | peroxidase activity(GO:0004601) |
0.0 | 7.2 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
0.0 | 0.1 | GO:0045295 | gamma-catenin binding(GO:0045295) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 2.3 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
0.0 | 1.8 | PID_E2F_PATHWAY | E2F transcription factor network |
0.0 | 0.9 | PID_P38_ALPHA_BETA_PATHWAY | Regulation of p38-alpha and p38-beta |
0.0 | 0.6 | NABA_COLLAGENS | Genes encoding collagen proteins |
0.0 | 1.4 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.7 | 25.6 | REACTOME_PACKAGING_OF_TELOMERE_ENDS | Genes involved in Packaging Of Telomere Ends |
0.1 | 2.3 | REACTOME_PURINE_SALVAGE | Genes involved in Purine salvage |
0.1 | 1.8 | REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
0.1 | 7.7 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
0.0 | 2.8 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |