Motif ID: Bcl6b

Z-value: 0.549


Transcription factors associated with Bcl6b:

Gene SymbolEntrez IDGene Name
Bcl6b ENSMUSG00000000317.5 Bcl6b

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Bcl6bmm10_v2_chr11_-_70229677_702297610.408.9e-03Click!


Activity profile for motif Bcl6b.

activity profile for motif Bcl6b


Sorted Z-values histogram for motif Bcl6b

Sorted Z-values for motif Bcl6b



Network of associatons between targets according to the STRING database.



First level regulatory network of Bcl6b

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_64046925 5.154 ENSMUST00000107377.3
Tnc
tenascin C
chr19_-_5797410 2.750 ENSMUST00000173314.1
Malat1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chr1_-_173942445 2.666 ENSMUST00000042228.8
ENSMUST00000081216.5
ENSMUST00000129829.1
ENSMUST00000123708.1
ENSMUST00000111210.2
Ifi203



Mndal
interferon activated gene 203



myeloid nuclear differentiation antigen like
chr16_-_74411776 2.520 ENSMUST00000116586.2
Robo2
roundabout homolog 2 (Drosophila)
chr10_+_57794335 2.200 ENSMUST00000151623.1
ENSMUST00000020022.7
Smpdl3a

sphingomyelin phosphodiesterase, acid-like 3A

chr16_-_74411292 2.093 ENSMUST00000117200.1
Robo2
roundabout homolog 2 (Drosophila)
chrX_+_151344171 2.090 ENSMUST00000073364.5
Fam120c
family with sequence similarity 120, member C
chr9_-_90255927 1.741 ENSMUST00000144646.1
Tbc1d2b
TBC1 domain family, member 2B
chr13_-_98815408 1.613 ENSMUST00000040340.8
ENSMUST00000099277.4
ENSMUST00000179563.1
ENSMUST00000109403.1
Fcho2



FCH domain only 2



chr10_+_81633694 1.468 ENSMUST00000140345.1
ENSMUST00000126323.1
Ankrd24

ankyrin repeat domain 24

chr2_-_65567505 1.365 ENSMUST00000100069.2
Scn3a
sodium channel, voltage-gated, type III, alpha
chr8_+_13907748 1.362 ENSMUST00000043520.3
Fbxo25
F-box protein 25
chr2_-_65567465 1.343 ENSMUST00000066432.5
Scn3a
sodium channel, voltage-gated, type III, alpha
chr12_-_40134175 1.314 ENSMUST00000078481.7
ENSMUST00000002640.5
Scin

scinderin

chr16_-_34263179 1.307 ENSMUST00000114949.1
ENSMUST00000114954.1
Kalrn

kalirin, RhoGEF kinase

chr16_-_34262830 1.217 ENSMUST00000114947.1
Kalrn
kalirin, RhoGEF kinase
chr2_+_119594288 1.182 ENSMUST00000147425.1
ENSMUST00000153581.1
1700020I14Rik

RIKEN cDNA 1700020I14 gene

chr12_-_98577940 1.134 ENSMUST00000110113.1
Kcnk10
potassium channel, subfamily K, member 10
chr2_-_180824596 1.015 ENSMUST00000148700.1
Gm14340
predicted gene 14340
chr6_+_149309444 0.991 ENSMUST00000100765.4
2810474O19Rik
RIKEN cDNA 2810474O19 gene
chr6_+_149309391 0.970 ENSMUST00000130664.1
ENSMUST00000046689.6
2810474O19Rik

RIKEN cDNA 2810474O19 gene

chr18_+_37320374 0.952 ENSMUST00000078271.2
Pcdhb5
protocadherin beta 5
chr5_-_123140135 0.926 ENSMUST00000160099.1
AI480526
expressed sequence AI480526
chr11_+_70764209 0.914 ENSMUST00000060444.5
Zfp3
zinc finger protein 3
chr16_-_34262945 0.884 ENSMUST00000114953.1
Kalrn
kalirin, RhoGEF kinase
chr5_-_150665560 0.846 ENSMUST00000118316.1
N4bp2l2
NEDD4 binding protein 2-like 2
chr10_-_95417099 0.843 ENSMUST00000135822.1
Socs2
suppressor of cytokine signaling 2
chr7_+_43579577 0.701 ENSMUST00000058104.7
Zfp719
zinc finger protein 719
chr8_+_12915879 0.701 ENSMUST00000110876.2
ENSMUST00000110879.2
Mcf2l

mcf.2 transforming sequence-like

chr15_+_25752860 0.693 ENSMUST00000022882.5
ENSMUST00000135173.1
Myo10

myosin X

chr1_+_82316452 0.678 ENSMUST00000027322.7
Rhbdd1
rhomboid domain containing 1
chr5_-_150665315 0.550 ENSMUST00000141857.1
N4bp2l2
NEDD4 binding protein 2-like 2
chr9_+_40269430 0.517 ENSMUST00000171835.2
Scn3b
sodium channel, voltage-gated, type III, beta
chr8_+_27042555 0.477 ENSMUST00000033875.8
ENSMUST00000098851.4
Prosc

proline synthetase co-transcribed

chr2_+_175283298 0.469 ENSMUST00000098998.3
Gm14440
predicted gene 14440
chr10_-_95416850 0.430 ENSMUST00000020215.9
Socs2
suppressor of cytokine signaling 2
chr11_+_58432559 0.411 ENSMUST00000108825.1
Gm12253
predicted gene 12253
chr3_+_95588960 0.351 ENSMUST00000176674.1
ENSMUST00000177389.1
ENSMUST00000176755.1
Golph3l


golgi phosphoprotein 3-like


chr3_+_95588990 0.334 ENSMUST00000177399.1
Golph3l
golgi phosphoprotein 3-like
chr17_-_45592569 0.325 ENSMUST00000163492.1
Slc29a1
solute carrier family 29 (nucleoside transporters), member 1
chr7_-_16221993 0.318 ENSMUST00000118795.1
ENSMUST00000119102.1
ENSMUST00000094816.2
ENSMUST00000163968.1
ENSMUST00000121123.1
Dhx34




DEAH (Asp-Glu-Ala-His) box polypeptide 34




chr8_+_25601591 0.315 ENSMUST00000155861.1
Whsc1l1
Wolf-Hirschhorn syndrome candidate 1-like 1 (human)
chr17_-_45592485 0.311 ENSMUST00000166119.1
Slc29a1
solute carrier family 29 (nucleoside transporters), member 1
chr15_-_54919961 0.308 ENSMUST00000167541.2
ENSMUST00000041591.9
ENSMUST00000173516.1
Enpp2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr18_+_42275353 0.303 ENSMUST00000046972.7
ENSMUST00000091920.5
Rbm27

RNA binding motif protein 27

chr6_-_128355826 0.300 ENSMUST00000001562.6
Tulp3
tubby-like protein 3
chr18_-_78123324 0.296 ENSMUST00000160292.1
ENSMUST00000091813.5
Slc14a1

solute carrier family 14 (urea transporter), member 1

chr3_+_55242526 0.282 ENSMUST00000054237.7
ENSMUST00000167204.1
Dclk1

doublecortin-like kinase 1

chr8_-_105568298 0.276 ENSMUST00000005849.5
Agrp
agouti related protein
chr3_+_95588928 0.243 ENSMUST00000177390.1
ENSMUST00000098861.4
ENSMUST00000060323.5
Golph3l


golgi phosphoprotein 3-like


chr6_+_29361410 0.228 ENSMUST00000156163.1
Calu
calumenin
chr10_-_86705485 0.207 ENSMUST00000020238.7
Hsp90b1
heat shock protein 90, beta (Grp94), member 1
chrX_+_74429671 0.181 ENSMUST00000114127.1
ENSMUST00000064407.3
ENSMUST00000156707.1
Ikbkg


inhibitor of kappaB kinase gamma


chr11_+_95712673 0.179 ENSMUST00000107717.1
Zfp652
zinc finger protein 652
chr5_+_130079370 0.175 ENSMUST00000040721.8
Tpst1
protein-tyrosine sulfotransferase 1
chr9_+_121938099 0.171 ENSMUST00000063103.4
1700048O20Rik
RIKEN cDNA 1700048O20 gene
chr3_+_84593547 0.170 ENSMUST00000062623.3
Tigd4
tigger transposable element derived 4
chr2_-_28583189 0.165 ENSMUST00000113889.2
Gtf3c5
general transcription factor IIIC, polypeptide 5
chr9_+_86743616 0.133 ENSMUST00000036426.6
Prss35
protease, serine, 35
chrX_+_152233228 0.132 ENSMUST00000112588.2
ENSMUST00000082177.6
Kdm5c

lysine (K)-specific demethylase 5C

chr6_+_124916863 0.124 ENSMUST00000069553.2
A230083G16Rik
RIKEN cDNA A230083G16 gene
chr6_+_34598500 0.120 ENSMUST00000079391.3
ENSMUST00000142512.1
Cald1

caldesmon 1

chr9_+_122923050 0.081 ENSMUST00000051667.7
ENSMUST00000148851.1
Zfp105

zinc finger protein 105

chr9_+_55326913 0.076 ENSMUST00000085754.3
ENSMUST00000034862.4
AI118078

expressed sequence AI118078

chr4_+_149485260 0.073 ENSMUST00000030842.7
Lzic
leucine zipper and CTNNBIP1 domain containing
chr18_-_3281036 0.070 ENSMUST00000049942.6
ENSMUST00000139537.1
ENSMUST00000124747.1
Crem


cAMP responsive element modulator


chr2_-_77946331 0.040 ENSMUST00000111821.2
ENSMUST00000111818.1
Cwc22

CWC22 spliceosome-associated protein homolog (S. cerevisiae)

chr11_-_80142123 0.034 ENSMUST00000131601.1
Tefm
transcription elongation factor, mitochondrial
chr3_+_84925476 0.027 ENSMUST00000107675.1
Fbxw7
F-box and WD-40 domain protein 7
chr4_+_3574872 0.022 ENSMUST00000052712.5
Tgs1
trimethylguanosine synthase homolog (S. cerevisiae)
chr9_+_13765970 0.003 ENSMUST00000152532.1
Mtmr2
myotubularin related protein 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.6 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
1.3 5.2 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.6 2.8 GO:0035063 nuclear speck organization(GO:0035063)
0.5 2.7 GO:0046684 response to pyrethroid(GO:0046684)
0.4 3.4 GO:0061368 maternal process involved in parturition(GO:0060137) behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.3 1.4 GO:1902037 negative regulation of hematopoietic stem cell differentiation(GO:1902037)
0.3 2.2 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.2 0.7 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.2 1.3 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.1 1.1 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 0.3 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.1 0.3 GO:0071918 urea transmembrane transport(GO:0071918)
0.1 0.6 GO:0015862 uridine transport(GO:0015862)
0.1 0.5 GO:0060371 regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371)
0.1 2.7 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.1 1.3 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.1 0.3 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.1 0.9 GO:0048194 Golgi vesicle budding(GO:0048194)
0.1 1.6 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.2 GO:0006478 peptidyl-tyrosine sulfation(GO:0006478)
0.0 0.3 GO:0008343 adult feeding behavior(GO:0008343)
0.0 0.2 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 0.7 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 0.1 GO:0034720 histone H3-K4 demethylation(GO:0034720)
0.0 1.7 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 0.2 GO:0071318 cellular response to ATP(GO:0071318)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0098835 presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835)
0.3 5.2 GO:0005614 interstitial matrix(GO:0005614)
0.2 3.2 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 4.6 GO:0030673 axolemma(GO:0030673)
0.1 0.7 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 0.3 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.3 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 0.2 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 1.4 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.2 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.2 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.9 GO:0031985 Golgi cisterna(GO:0031985)
0.0 0.1 GO:0030478 actin cap(GO:0030478)
0.0 0.7 GO:0016459 myosin complex(GO:0016459)
0.0 1.2 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 1.3 GO:0005903 brush border(GO:0005903)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 5.2 GO:0045545 syndecan binding(GO:0045545)
0.6 4.6 GO:0008046 axon guidance receptor activity(GO:0008046)
0.3 2.2 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.3 1.3 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.1 2.7 GO:0031402 sodium ion binding(GO:0031402)
0.1 3.4 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 1.1 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 0.5 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.1 0.2 GO:1990450 linear polyubiquitin binding(GO:1990450)
0.1 0.3 GO:0015265 urea channel activity(GO:0015265)
0.1 0.2 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.1 0.2 GO:0000992 polymerase III regulatory region sequence-specific DNA binding(GO:0000992) RNA polymerase III type 1 promoter sequence-specific DNA binding(GO:0001002) RNA polymerase III type 2 promoter sequence-specific DNA binding(GO:0001003) RNA polymerase III transcription factor activity, sequence-specific DNA binding(GO:0001034)
0.0 0.2 GO:0008476 protein-tyrosine sulfotransferase activity(GO:0008476)
0.0 0.7 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 1.4 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 1.6 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.9 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.2 GO:0046790 virion binding(GO:0046790)
0.0 0.6 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 0.1 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.0 0.3 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 2.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.7 GO:0030507 spectrin binding(GO:0030507)
0.0 1.7 GO:0017137 Rab GTPase binding(GO:0017137)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.2 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.1 3.4 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.7 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.3 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 1.1 PID_IL2_1PATHWAY IL2-mediated signaling events
0.0 0.7 PID_NETRIN_PATHWAY Netrin-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 4.6 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.1 4.9 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 3.4 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 1.1 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.0 0.2 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.2 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.6 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.3 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 0.7 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 0.5 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins