Motif ID: E2f7

Z-value: 1.805


Transcription factors associated with E2f7:

Gene SymbolEntrez IDGene Name
E2f7 ENSMUSG00000020185.10 E2f7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f7mm10_v2_chr10_+_110745433_1107455720.689.0e-07Click!


Activity profile for motif E2f7.

activity profile for motif E2f7


Sorted Z-values histogram for motif E2f7

Sorted Z-values for motif E2f7



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f7

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_116308241 21.972 ENSMUST00000183057.1
ENSMUST00000182487.1
ENSMUST00000181998.1
Plekha7


pleckstrin homology domain containing, family A member 7


chr9_+_3013140 20.089 ENSMUST00000143083.2
Gm10721
predicted gene 10721
chr9_+_3037111 19.968 ENSMUST00000177969.1
Gm10715
predicted gene 10715
chr9_+_3025417 17.559 ENSMUST00000075573.6
Gm10717
predicted gene 10717
chr9_+_3017408 15.002 ENSMUST00000099049.3
Gm10719
predicted gene 10719
chr9_+_3015654 14.551 ENSMUST00000099050.3
Gm10720
predicted gene 10720
chr4_+_108579445 11.275 ENSMUST00000102744.3
Orc1
origin recognition complex, subunit 1
chr2_+_72476159 10.104 ENSMUST00000102691.4
Cdca7
cell division cycle associated 7
chr10_-_69352886 9.417 ENSMUST00000119827.1
ENSMUST00000020099.5
Cdk1

cyclin-dependent kinase 1

chr15_+_102296256 9.258 ENSMUST00000064924.4
Espl1
extra spindle poles-like 1 (S. cerevisiae)
chr8_+_75109528 8.789 ENSMUST00000164309.1
Mcm5
minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
chr2_+_72476225 8.750 ENSMUST00000157019.1
Cdca7
cell division cycle associated 7
chr11_+_102248842 8.728 ENSMUST00000100392.4
BC030867
cDNA sequence BC030867
chr12_+_24708984 8.689 ENSMUST00000154588.1
Rrm2
ribonucleotide reductase M2
chr13_-_100775844 7.880 ENSMUST00000075550.3
Cenph
centromere protein H
chr10_+_3973086 7.232 ENSMUST00000117291.1
ENSMUST00000120585.1
ENSMUST00000043735.7
Mthfd1l


methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like


chr12_+_24708241 7.165 ENSMUST00000020980.5
Rrm2
ribonucleotide reductase M2
chr2_-_36104060 7.080 ENSMUST00000112961.3
ENSMUST00000112966.3
Lhx6

LIM homeobox protein 6

chr13_+_23581563 6.606 ENSMUST00000102968.1
Hist1h4d
histone cluster 1, H4d
chr4_+_132768325 6.552 ENSMUST00000102561.4
Rpa2
replication protein A2
chr2_-_157204483 6.229 ENSMUST00000029170.7
Rbl1
retinoblastoma-like 1 (p107)
chr11_-_77513335 6.104 ENSMUST00000060417.4
Trp53i13
transformation related protein 53 inducible protein 13
chr3_+_108383829 5.885 ENSMUST00000090561.3
ENSMUST00000102629.1
ENSMUST00000128089.1
Psrc1


proline/serine-rich coiled-coil 1


chr6_+_15721087 5.796 ENSMUST00000120512.1
Mdfic
MyoD family inhibitor domain containing
chr4_+_136172367 5.612 ENSMUST00000061721.5
E2f2
E2F transcription factor 2
chr17_-_35516780 5.554 ENSMUST00000160885.1
ENSMUST00000159009.1
ENSMUST00000161012.1
Tcf19


transcription factor 19


chr13_-_21783391 5.546 ENSMUST00000099704.3
Hist1h3i
histone cluster 1, H3i
chr13_+_22035821 5.462 ENSMUST00000110455.2
Hist1h2bk
histone cluster 1, H2bk
chr13_-_21833575 5.354 ENSMUST00000081342.5
Hist1h2ap
histone cluster 1, H2ap
chr19_-_41206774 5.164 ENSMUST00000025986.7
ENSMUST00000169941.1
Tll2

tolloid-like 2

chr7_-_44548733 5.160 ENSMUST00000145956.1
ENSMUST00000049343.8
Pold1

polymerase (DNA directed), delta 1, catalytic subunit

chr14_-_20388822 4.979 ENSMUST00000022345.6
Dnajc9
DnaJ (Hsp40) homolog, subfamily C, member 9
chr2_+_112261926 4.815 ENSMUST00000028553.3
Nop10
NOP10 ribonucleoprotein
chr6_-_88898664 4.348 ENSMUST00000058011.6
Mcm2
minichromosome maintenance deficient 2 mitotin (S. cerevisiae)
chr15_+_79030874 4.122 ENSMUST00000171999.1
ENSMUST00000006544.7
Gcat

glycine C-acetyltransferase (2-amino-3-ketobutyrate-coenzyme A ligase)

chr13_+_22043189 4.122 ENSMUST00000110452.1
Hist1h2bj
histone cluster 1, H2bj
chr9_+_64281575 4.049 ENSMUST00000034964.6
Tipin
timeless interacting protein
chr1_-_128359610 4.019 ENSMUST00000027601.4
Mcm6
minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)
chr12_+_112146187 3.919 ENSMUST00000128402.2
Kif26a
kinesin family member 26A
chr13_-_55329723 3.901 ENSMUST00000021941.7
Mxd3
Max dimerization protein 3
chrX_+_153006461 3.867 ENSMUST00000095755.3
Usp51
ubiquitin specific protease 51
chr7_-_142578139 3.861 ENSMUST00000136359.1
H19
H19 fetal liver mRNA
chr13_-_22042949 3.850 ENSMUST00000091741.4
Hist1h2ag
histone cluster 1, H2ag
chr13_+_21810428 3.807 ENSMUST00000091745.5
Hist1h2ao
histone cluster 1, H2ao
chr13_+_21754067 3.802 ENSMUST00000091709.2
Hist1h2bn
histone cluster 1, H2bn
chr5_+_129020069 3.662 ENSMUST00000031383.7
ENSMUST00000111343.1
Ran

RAN, member RAS oncogene family

chrX_+_162760388 3.656 ENSMUST00000033720.5
ENSMUST00000112327.1
Rbbp7

retinoblastoma binding protein 7

chr11_-_6444352 3.650 ENSMUST00000093346.5
ENSMUST00000109737.2
H2afv

H2A histone family, member V

chr13_-_97198351 3.620 ENSMUST00000022169.7
Hexb
hexosaminidase B
chr13_+_21833736 3.576 ENSMUST00000180288.1
ENSMUST00000110467.1
Hist1h2br

histone cluster 1 H2br

chr13_-_22035589 3.474 ENSMUST00000091742.4
Hist1h2ah
histone cluster 1, H2ah
chr17_-_24960620 3.258 ENSMUST00000024981.7
Hn1l
hematological and neurological expressed 1-like
chr5_+_9100681 3.186 ENSMUST00000115365.1
Tmem243
transmembrane protein 243, mitochondrial
chr7_+_110122299 3.143 ENSMUST00000033326.8
Wee1
WEE 1 homolog 1 (S. pombe)
chr18_+_56707725 3.072 ENSMUST00000025486.8
Lmnb1
lamin B1
chr13_-_21716143 3.049 ENSMUST00000091756.1
Hist1h2bl
histone cluster 1, H2bl
chr10_-_35711891 3.034 ENSMUST00000080898.2
Amd2
S-adenosylmethionine decarboxylase 2
chr12_-_11265768 2.971 ENSMUST00000166117.1
Gen1
Gen homolog 1, endonuclease (Drosophila)
chr13_-_21810190 2.870 ENSMUST00000110469.1
ENSMUST00000091749.2
Hist1h2bq

histone cluster 1, H2bq

chr13_-_21753851 2.726 ENSMUST00000074752.2
Hist1h2ak
histone cluster 1, H2ak
chr7_-_44816586 2.714 ENSMUST00000047356.8
Atf5
activating transcription factor 5
chr4_+_126556935 2.686 ENSMUST00000048391.8
Clspn
claspin
chr7_+_28169744 2.669 ENSMUST00000042405.6
Fbl
fibrillarin
chr10_+_91082940 2.518 ENSMUST00000020150.3
Ikbip
IKBKB interacting protein
chr2_+_18672384 2.440 ENSMUST00000171845.1
ENSMUST00000061158.4
Commd3

COMM domain containing 3

chr13_+_21716385 2.438 ENSMUST00000070124.3
Hist1h2ai
histone cluster 1, H2ai
chr4_+_126556994 2.413 ENSMUST00000147675.1
Clspn
claspin
chr14_+_54254124 2.352 ENSMUST00000180359.1
Abhd4
abhydrolase domain containing 4
chr17_+_34850373 2.168 ENSMUST00000097343.4
ENSMUST00000173357.1
ENSMUST00000173065.1
ENSMUST00000165953.2
Nelfe



negative elongation factor complex member E, Rdbp



chr1_+_86526688 2.083 ENSMUST00000045897.8
Ptma
prothymosin alpha
chr14_-_54641347 1.996 ENSMUST00000067784.6
Cdh24
cadherin-like 24
chr4_+_124714776 1.986 ENSMUST00000030734.4
Sf3a3
splicing factor 3a, subunit 3
chr2_+_23321246 1.953 ENSMUST00000102945.1
Nxph2
neurexophilin 2
chr1_+_180568913 1.855 ENSMUST00000027777.6
Parp1
poly (ADP-ribose) polymerase family, member 1
chr17_+_33524170 1.784 ENSMUST00000087623.6
Adamts10
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 10
chr13_+_23574381 1.570 ENSMUST00000090776.4
Hist1h2ad
histone cluster 1, H2ad
chr12_-_73286698 1.562 ENSMUST00000116420.2
Trmt5
TRM5 tRNA methyltransferase 5
chr15_-_81871883 1.555 ENSMUST00000023117.8
Phf5a
PHD finger protein 5A
chr17_+_35517100 1.536 ENSMUST00000164242.2
ENSMUST00000045956.7
Cchcr1

coiled-coil alpha-helical rod protein 1

chr10_+_11281304 1.532 ENSMUST00000129456.1
Fbxo30
F-box protein 30
chr11_-_87404380 1.501 ENSMUST00000067692.6
Rad51c
RAD51 homolog C
chr17_-_25792284 1.436 ENSMUST00000072735.7
Fam173a
family with sequence similarity 173, member A
chr9_+_44334685 1.427 ENSMUST00000052686.2
H2afx
H2A histone family, member X
chr13_+_23555023 1.414 ENSMUST00000045301.6
Hist1h1d
histone cluster 1, H1d
chr13_-_23574196 1.352 ENSMUST00000105106.1
Hist1h2bf
histone cluster 1, H2bf
chr7_+_66109474 1.302 ENSMUST00000036372.6
Chsy1
chondroitin sulfate synthase 1
chr16_+_38346986 1.296 ENSMUST00000050273.8
ENSMUST00000120495.1
ENSMUST00000119704.1
Cox17

Gm21987
cytochrome c oxidase assembly protein 17

predicted gene 21987
chr19_-_10881677 1.267 ENSMUST00000128835.1
Tmem109
transmembrane protein 109
chr19_-_10881723 1.212 ENSMUST00000144681.1
Tmem109
transmembrane protein 109
chr7_+_44816088 1.092 ENSMUST00000057195.9
ENSMUST00000107891.1
Nup62

nucleoporin 62

chr1_-_180813591 1.080 ENSMUST00000162118.1
ENSMUST00000159685.1
ENSMUST00000161308.1
H3f3a


H3 histone, family 3A


chr14_-_54253907 1.056 ENSMUST00000128231.1
Dad1
defender against cell death 1
chr2_+_130667610 1.050 ENSMUST00000103193.4
Itpa
inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
chr6_-_67037399 0.790 ENSMUST00000043098.6
Gadd45a
growth arrest and DNA-damage-inducible 45 alpha
chr8_+_72319033 0.789 ENSMUST00000067912.7
Klf2
Kruppel-like factor 2 (lung)
chr5_+_129941949 0.757 ENSMUST00000051758.7
ENSMUST00000073945.4
Vkorc1l1

vitamin K epoxide reductase complex, subunit 1-like 1

chr1_-_135167606 0.719 ENSMUST00000027682.8
Gpr37l1
G protein-coupled receptor 37-like 1
chrX_-_37085402 0.715 ENSMUST00000115231.3
Rpl39
ribosomal protein L39
chr17_-_12916345 0.714 ENSMUST00000079121.3
Mrpl18
mitochondrial ribosomal protein L18
chr11_+_88047693 0.617 ENSMUST00000079866.4
Srsf1
serine/arginine-rich splicing factor 1
chr1_-_191183244 0.552 ENSMUST00000027941.8
Atf3
activating transcription factor 3
chr19_+_8723478 0.531 ENSMUST00000180819.1
ENSMUST00000181422.1
Snhg1

small nucleolar RNA host gene (non-protein coding) 1

chr11_-_61762040 0.520 ENSMUST00000004955.7
ENSMUST00000168115.1
Prpsap2

phosphoribosyl pyrophosphate synthetase-associated protein 2

chr4_+_94739276 0.473 ENSMUST00000073939.6
ENSMUST00000102798.1
Tek

endothelial-specific receptor tyrosine kinase

chr2_-_180920925 0.473 ENSMUST00000037299.8
ENSMUST00000108876.2
Ythdf1

YTH domain family 1

chr17_+_12916329 0.471 ENSMUST00000089024.6
ENSMUST00000151287.1
ENSMUST00000143961.1
Tcp1


t-complex protein 1


chr1_+_172521044 0.454 ENSMUST00000085894.5
ENSMUST00000161140.1
ENSMUST00000162988.1
Ccdc19


coiled-coil domain containing 19


chr10_+_91083036 0.422 ENSMUST00000020149.5
Ikbip
IKBKB interacting protein
chr1_+_74506044 0.403 ENSMUST00000087215.5
Rqcd1
rcd1 (required for cell differentiation) homolog 1 (S. pombe)
chr14_+_4334763 0.393 ENSMUST00000165466.1
2610042L04Rik
RIKEN cDNA 2610042L04 gene
chr3_-_57847478 0.313 ENSMUST00000120289.1
ENSMUST00000066882.8
Pfn2

profilin 2

chr17_+_28691342 0.216 ENSMUST00000114758.1
ENSMUST00000004990.6
ENSMUST00000062694.8
ENSMUST00000114754.1
Mapk14



mitogen-activated protein kinase 14



chr7_-_28598140 0.211 ENSMUST00000108283.1
ENSMUST00000040531.8
Pak4
Samd4b
p21 protein (Cdc42/Rac)-activated kinase 4
sterile alpha motif domain containing 4B
chr10_+_11281583 0.209 ENSMUST00000070300.4
Fbxo30
F-box protein 30
chr14_+_5071040 0.143 ENSMUST00000163719.1
Gm8281
predicted gene, 8281
chr4_+_108619925 0.130 ENSMUST00000030320.6
Cc2d1b
coiled-coil and C2 domain containing 1B
chr5_-_137533170 0.103 ENSMUST00000168746.1
ENSMUST00000170293.1
Gnb2

guanine nucleotide binding protein (G protein), beta 2

chr14_+_4726775 0.078 ENSMUST00000165619.1
Gm3252
predicted gene 3252
chr17_+_25773769 0.060 ENSMUST00000134108.1
ENSMUST00000002350.4
Narfl

nuclear prelamin A recognition factor-like

chr14_-_6038209 0.008 ENSMUST00000164139.1
Gm8206
predicted gene 8206

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.7 22.0 GO:0045218 zonula adherens maintenance(GO:0045218)
2.8 11.3 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
1.7 5.2 GO:0045004 DNA replication proofreading(GO:0045004)
1.4 7.2 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
1.2 3.6 GO:0007341 penetration of zona pellucida(GO:0007341)
1.2 7.1 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
1.0 5.2 GO:0048631 regulation of skeletal muscle tissue growth(GO:0048631)
1.0 3.1 GO:0031660 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662)
1.0 3.0 GO:0006597 spermine biosynthetic process(GO:0006597)
1.0 4.8 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
0.9 10.6 GO:0002227 innate immune response in mucosa(GO:0002227)
0.9 15.9 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.8 8.4 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.8 7.4 GO:0090166 Golgi disassembly(GO:0090166)
0.8 5.6 GO:1990086 lens fiber cell apoptotic process(GO:1990086)
0.7 9.3 GO:0000212 meiotic spindle organization(GO:0000212)
0.6 1.9 GO:1904760 myofibroblast differentiation(GO:0036446) regulation of myofibroblast differentiation(GO:1904760)
0.6 9.1 GO:0000076 DNA replication checkpoint(GO:0000076)
0.5 2.7 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
0.5 3.7 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.4 1.3 GO:1904959 regulation of electron carrier activity(GO:1904732) regulation of cytochrome-c oxidase activity(GO:1904959)
0.4 12.2 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.4 1.6 GO:1900864 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.4 1.5 GO:0007066 female meiosis sister chromatid cohesion(GO:0007066)
0.4 1.1 GO:1903490 regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490)
0.4 3.9 GO:2000653 regulation of genetic imprinting(GO:2000653)
0.3 3.0 GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
0.3 3.9 GO:0048484 enteric nervous system development(GO:0048484)
0.3 8.8 GO:0006270 DNA replication initiation(GO:0006270)
0.3 6.6 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.3 1.1 GO:1902340 telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340)
0.3 4.3 GO:0051382 kinetochore assembly(GO:0051382)
0.3 0.8 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.2 2.2 GO:1900364 negative regulation of mRNA polyadenylation(GO:1900364)
0.2 0.7 GO:0035928 rRNA import into mitochondrion(GO:0035928)
0.2 1.4 GO:0016584 nucleosome positioning(GO:0016584)
0.2 5.8 GO:0050434 positive regulation of viral transcription(GO:0050434)
0.2 22.9 GO:0006342 chromatin silencing(GO:0006342)
0.2 5.9 GO:0090224 regulation of mitotic spindle organization(GO:0060236) regulation of spindle organization(GO:0090224)
0.2 5.6 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.2 3.4 GO:0021924 cell proliferation in external granule layer(GO:0021924) cerebellar granule cell precursor proliferation(GO:0021930)
0.2 0.5 GO:0048014 Tie signaling pathway(GO:0048014)
0.1 1.0 GO:0009146 purine nucleoside triphosphate catabolic process(GO:0009146)
0.1 1.3 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.1 3.9 GO:0016578 histone deubiquitination(GO:0016578)
0.1 0.6 GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.1 6.2 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.1 0.8 GO:0071499 response to laminar fluid shear stress(GO:0034616) cellular response to laminar fluid shear stress(GO:0071499)
0.1 0.5 GO:2000109 macrophage apoptotic process(GO:0071888) regulation of macrophage apoptotic process(GO:2000109)
0.1 2.1 GO:0043486 histone exchange(GO:0043486)
0.1 5.3 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.1 0.4 GO:0060025 regulation of synaptic activity(GO:0060025)
0.1 0.8 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.1 4.5 GO:0006334 nucleosome assembly(GO:0006334)
0.1 3.7 GO:0034605 cellular response to heat(GO:0034605)
0.1 2.5 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.1 0.2 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835)
0.0 0.5 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.0 3.1 GO:0018108 peptidyl-tyrosine phosphorylation(GO:0018108)
0.0 1.5 GO:0006611 protein export from nucleus(GO:0006611)
0.0 2.4 GO:0006814 sodium ion transport(GO:0006814)
0.0 1.1 GO:0006487 protein N-linked glycosylation(GO:0006487)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 15.9 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
2.0 22.0 GO:0005915 zonula adherens(GO:0005915)
2.0 15.6 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
1.7 5.2 GO:0043625 delta DNA polymerase complex(GO:0043625)
1.2 3.7 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
1.2 4.8 GO:0090661 box H/ACA telomerase RNP complex(GO:0090661)
0.7 10.4 GO:0042555 MCM complex(GO:0042555)
0.7 4.0 GO:0031298 replication fork protection complex(GO:0031298)
0.7 2.7 GO:0001651 dense fibrillar component(GO:0001651)
0.5 2.2 GO:0032021 NELF complex(GO:0032021)
0.5 6.6 GO:0005662 DNA replication factor A complex(GO:0005662)
0.4 31.4 GO:0000786 nucleosome(GO:0000786)
0.4 3.1 GO:0005638 lamin filament(GO:0005638)
0.3 3.6 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.3 1.5 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063) Holliday junction resolvase complex(GO:0048476)
0.2 19.8 GO:0072686 mitotic spindle(GO:0072686)
0.2 3.7 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 1.8 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.1 0.5 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.1 1.3 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 1.6 GO:0005686 U2 snRNP(GO:0005686)
0.1 3.9 GO:0005871 kinesin complex(GO:0005871)
0.1 1.1 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 6.1 GO:0000922 spindle pole(GO:0000922)
0.1 9.5 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.5 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 2.1 GO:0005844 polysome(GO:0005844)
0.0 2.5 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.0 1.9 GO:0032993 protein-DNA complex(GO:0032993)
0.0 6.3 GO:0000790 nuclear chromatin(GO:0000790)
0.0 5.3 GO:0005667 transcription factor complex(GO:0005667)
0.0 1.3 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 1.5 GO:0005814 centriole(GO:0005814)
0.0 10.2 GO:0005730 nucleolus(GO:0005730)
0.0 0.7 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.1 GO:0097361 CIA complex(GO:0097361)
0.0 1.0 GO:0071013 catalytic step 2 spliceosome(GO:0071013)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 15.9 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
2.0 24.0 GO:0070097 delta-catenin binding(GO:0070097)
1.8 7.2 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.9 13.1 GO:0003688 DNA replication origin binding(GO:0003688)
0.8 5.1 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.8 3.9 GO:0043515 kinetochore binding(GO:0043515)
0.8 3.0 GO:0019808 polyamine binding(GO:0019808)
0.7 3.6 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.7 4.8 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.6 3.7 GO:0070883 pre-miRNA binding(GO:0070883)
0.6 5.2 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.6 4.5 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.5 8.2 GO:0035173 histone kinase activity(GO:0035173)
0.5 6.4 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.4 1.3 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.4 5.8 GO:0030957 Tat protein binding(GO:0030957)
0.3 2.7 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.3 1.9 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.3 1.0 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.2 1.1 GO:0051425 PTB domain binding(GO:0051425)
0.2 1.6 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.2 6.2 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.2 1.3 GO:0016531 copper chaperone activity(GO:0016531)
0.2 6.6 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 0.5 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.1 3.1 GO:0043274 phospholipase binding(GO:0043274)
0.1 4.0 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 1.1 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1 6.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 5.2 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 0.5 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.1 3.1 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 11.5 GO:0042393 histone binding(GO:0042393)
0.1 0.7 GO:0008097 5S rRNA binding(GO:0008097)
0.1 0.8 GO:0048038 quinone binding(GO:0048038)
0.0 7.7 GO:0031072 heat shock protein binding(GO:0031072)
0.0 3.9 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.2 GO:0051525 NFAT protein binding(GO:0051525)
0.0 56.4 GO:0003677 DNA binding(GO:0003677)
0.0 0.5 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 2.5 GO:0005244 voltage-gated ion channel activity(GO:0005244) voltage-gated channel activity(GO:0022832)
0.0 0.7 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.0 0.2 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 2.4 GO:0008017 microtubule binding(GO:0008017)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 12.6 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.5 5.6 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.4 20.0 PID_ATR_PATHWAY ATR signaling pathway
0.4 33.4 PID_E2F_PATHWAY E2F transcription factor network
0.4 22.0 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.2 3.7 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.2 17.7 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 2.7 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.1 1.9 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 3.1 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 3.7 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.1 5.8 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 1.4 PID_ATM_PATHWAY ATM pathway
0.0 6.9 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.6 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 0.5 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.5 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 5.6 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
2.1 20.7 REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
1.2 11.7 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
1.1 17.2 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
1.1 15.9 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.8 27.4 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.5 11.5 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.4 3.1 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.4 6.2 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.4 3.6 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.3 6.6 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.2 3.7 REACTOME_MICRORNA_MIRNA_BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.1 3.9 REACTOME_KINESINS Genes involved in Kinesins
0.1 1.4 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 3.1 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.1 5.2 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 1.3 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 1.9 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 1.1 REACTOME_TRANSPORT_OF_RIBONUCLEOPROTEINS_INTO_THE_HOST_NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0 1.3 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.2 REACTOME_DESTABILIZATION_OF_MRNA_BY_KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 0.6 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.5 REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 0.5 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 1.5 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.2 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 1.1 REACTOME_ASPARAGINE_N_LINKED_GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation