Motif ID: Isl2
Z-value: 0.781

Transcription factors associated with Isl2:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Isl2 | ENSMUSG00000032318.6 | Isl2 |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.1 | 3.2 | GO:0015938 | coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034) acetyl-CoA catabolic process(GO:0046356) |
1.0 | 3.0 | GO:0016554 | cytidine to uridine editing(GO:0016554) |
0.8 | 2.5 | GO:0002191 | cap-dependent translational initiation(GO:0002191) |
0.7 | 2.0 | GO:0071963 | establishment or maintenance of cell polarity regulating cell shape(GO:0071963) |
0.5 | 1.6 | GO:0009106 | lipoate metabolic process(GO:0009106) |
0.4 | 1.6 | GO:0072592 | regulation of integrin biosynthetic process(GO:0045113) oxygen metabolic process(GO:0072592) |
0.4 | 1.2 | GO:0036292 | DNA rewinding(GO:0036292) |
0.4 | 2.6 | GO:1990086 | lens fiber cell apoptotic process(GO:1990086) |
0.3 | 0.9 | GO:0060489 | orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490) |
0.3 | 1.3 | GO:0006177 | GMP biosynthetic process(GO:0006177) |
0.3 | 1.8 | GO:0051461 | protein import into peroxisome matrix, docking(GO:0016560) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461) |
0.2 | 0.7 | GO:2000393 | negative regulation of lamellipodium morphogenesis(GO:2000393) |
0.2 | 0.7 | GO:0048162 | preantral ovarian follicle growth(GO:0001546) multi-layer follicle stage(GO:0048162) |
0.2 | 1.6 | GO:0019532 | oxalate transport(GO:0019532) |
0.2 | 4.7 | GO:0007530 | sex determination(GO:0007530) |
0.2 | 1.7 | GO:0071557 | histone H3-K27 demethylation(GO:0071557) |
0.2 | 0.9 | GO:0019287 | isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287) |
0.2 | 0.8 | GO:0000957 | mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960) |
0.2 | 1.0 | GO:0052695 | cellular glucuronidation(GO:0052695) |
0.2 | 0.5 | GO:2000435 | regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435) |
0.2 | 0.7 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) |
0.2 | 2.3 | GO:0034219 | carbohydrate transmembrane transport(GO:0034219) |
0.2 | 1.2 | GO:0043569 | negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569) |
0.2 | 1.0 | GO:1901837 | negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837) |
0.2 | 3.2 | GO:2000353 | positive regulation of endothelial cell apoptotic process(GO:2000353) |
0.2 | 0.5 | GO:0046341 | CDP-diacylglycerol metabolic process(GO:0046341) |
0.1 | 0.8 | GO:1901164 | negative regulation of trophoblast cell migration(GO:1901164) |
0.1 | 0.8 | GO:0009235 | cobalamin metabolic process(GO:0009235) |
0.1 | 0.7 | GO:0036337 | Fas signaling pathway(GO:0036337) |
0.1 | 2.3 | GO:0071803 | keratinocyte development(GO:0003334) positive regulation of podosome assembly(GO:0071803) |
0.1 | 0.3 | GO:0006428 | isoleucyl-tRNA aminoacylation(GO:0006428) |
0.1 | 1.1 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
0.1 | 1.2 | GO:0060294 | cilium movement involved in cell motility(GO:0060294) |
0.1 | 2.2 | GO:0006825 | copper ion transport(GO:0006825) |
0.1 | 0.8 | GO:0048664 | neuron fate determination(GO:0048664) |
0.1 | 2.1 | GO:0097352 | autophagosome maturation(GO:0097352) |
0.1 | 1.0 | GO:0072520 | seminiferous tubule development(GO:0072520) |
0.1 | 0.8 | GO:0042407 | cristae formation(GO:0042407) |
0.0 | 1.5 | GO:0000027 | ribosomal large subunit assembly(GO:0000027) |
0.0 | 1.3 | GO:0008340 | determination of adult lifespan(GO:0008340) |
0.0 | 0.2 | GO:1902340 | telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340) |
0.0 | 0.3 | GO:0002681 | somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153) double-strand break repair via classical nonhomologous end joining(GO:0097680) |
0.0 | 0.5 | GO:0042572 | retinol metabolic process(GO:0042572) |
0.0 | 1.9 | GO:0021591 | ventricular system development(GO:0021591) |
0.0 | 0.6 | GO:0060059 | embryonic retina morphogenesis in camera-type eye(GO:0060059) |
0.0 | 1.5 | GO:0042462 | eye photoreceptor cell development(GO:0042462) |
0.0 | 0.7 | GO:0048096 | chromatin-mediated maintenance of transcription(GO:0048096) |
0.0 | 0.5 | GO:0070131 | positive regulation of mitochondrial translation(GO:0070131) |
0.0 | 0.2 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
0.0 | 0.4 | GO:0060965 | negative regulation of gene silencing by miRNA(GO:0060965) |
0.0 | 1.2 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
0.0 | 0.7 | GO:0051123 | RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123) |
0.0 | 0.9 | GO:0006182 | cGMP biosynthetic process(GO:0006182) |
0.0 | 0.1 | GO:0045162 | clustering of voltage-gated sodium channels(GO:0045162) |
0.0 | 1.9 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
0.0 | 0.2 | GO:0071763 | nuclear membrane organization(GO:0071763) |
0.0 | 0.4 | GO:2000001 | regulation of DNA damage checkpoint(GO:2000001) |
0.0 | 0.7 | GO:0010390 | histone monoubiquitination(GO:0010390) |
0.0 | 0.2 | GO:0016191 | synaptic vesicle uncoating(GO:0016191) |
0.0 | 0.4 | GO:0010800 | positive regulation of peptidyl-threonine phosphorylation(GO:0010800) |
0.0 | 0.5 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
0.0 | 0.0 | GO:0072319 | vesicle uncoating(GO:0072319) |
0.0 | 0.1 | GO:0045835 | negative regulation of meiotic nuclear division(GO:0045835) |
0.0 | 0.7 | GO:0009060 | aerobic respiration(GO:0009060) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 1.8 | GO:0017071 | intracellular cyclic nucleotide activated cation channel complex(GO:0017071) |
0.4 | 1.6 | GO:0071438 | invadopodium membrane(GO:0071438) |
0.3 | 1.2 | GO:0042567 | insulin-like growth factor ternary complex(GO:0042567) |
0.2 | 0.9 | GO:0060187 | cell pole(GO:0060187) |
0.2 | 2.5 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
0.2 | 0.5 | GO:0036156 | inner dynein arm(GO:0036156) |
0.1 | 1.0 | GO:0001740 | Barr body(GO:0001740) |
0.1 | 0.7 | GO:0005672 | transcription factor TFIIA complex(GO:0005672) |
0.1 | 1.0 | GO:0005828 | kinetochore microtubule(GO:0005828) |
0.1 | 0.2 | GO:0070469 | respiratory chain(GO:0070469) |
0.1 | 0.6 | GO:0005638 | lamin filament(GO:0005638) |
0.1 | 0.8 | GO:0061617 | MICOS complex(GO:0061617) |
0.1 | 1.1 | GO:0000974 | Prp19 complex(GO:0000974) |
0.1 | 2.3 | GO:0002102 | podosome(GO:0002102) |
0.0 | 0.9 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
0.0 | 0.3 | GO:0005958 | DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) DNA ligase IV complex(GO:0032807) |
0.0 | 2.7 | GO:0005581 | collagen trimer(GO:0005581) |
0.0 | 1.7 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
0.0 | 6.0 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
0.0 | 0.5 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
0.0 | 1.9 | GO:0005871 | kinesin complex(GO:0005871) |
0.0 | 1.1 | GO:0043596 | nuclear replication fork(GO:0043596) |
0.0 | 0.4 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
0.0 | 1.5 | GO:0005902 | microvillus(GO:0005902) |
0.0 | 0.6 | GO:0035145 | exon-exon junction complex(GO:0035145) |
0.0 | 1.0 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
0.0 | 0.4 | GO:0031305 | integral component of mitochondrial inner membrane(GO:0031305) |
0.0 | 1.1 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
0.0 | 0.7 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
0.0 | 1.3 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
0.0 | 0.1 | GO:0071439 | clathrin complex(GO:0071439) |
0.0 | 2.1 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
0.0 | 0.1 | GO:0030896 | checkpoint clamp complex(GO:0030896) |
0.0 | 1.8 | GO:0000776 | kinetochore(GO:0000776) |
0.0 | 0.4 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.1 | 3.2 | GO:0003986 | acetyl-CoA hydrolase activity(GO:0003986) |
0.8 | 3.0 | GO:0004126 | cytidine deaminase activity(GO:0004126) |
0.6 | 1.8 | GO:0030368 | interleukin-17 receptor activity(GO:0030368) |
0.5 | 1.6 | GO:0030171 | voltage-gated proton channel activity(GO:0030171) |
0.4 | 2.1 | GO:0004322 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
0.4 | 2.5 | GO:0071074 | eukaryotic initiation factor eIF2 binding(GO:0071074) |
0.4 | 1.8 | GO:0005052 | peroxisome matrix targeting signal-1 binding(GO:0005052) |
0.3 | 1.3 | GO:0003938 | IMP dehydrogenase activity(GO:0003938) |
0.2 | 1.7 | GO:0071558 | histone demethylase activity (H3-K27 specific)(GO:0071558) |
0.2 | 1.2 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
0.1 | 1.6 | GO:0019531 | secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531) |
0.1 | 0.7 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
0.1 | 0.7 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
0.1 | 4.7 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
0.1 | 0.8 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
0.1 | 2.4 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
0.1 | 0.7 | GO:0032184 | SUMO polymer binding(GO:0032184) |
0.1 | 1.5 | GO:0004862 | cAMP-dependent protein kinase inhibitor activity(GO:0004862) |
0.1 | 1.2 | GO:0036310 | annealing helicase activity(GO:0036310) |
0.1 | 0.3 | GO:0004822 | isoleucine-tRNA ligase activity(GO:0004822) |
0.1 | 2.9 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
0.1 | 0.5 | GO:1990948 | ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948) |
0.1 | 1.3 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
0.1 | 0.5 | GO:0017169 | CDP-alcohol phosphatidyltransferase activity(GO:0017169) |
0.1 | 0.7 | GO:0042923 | neuropeptide binding(GO:0042923) |
0.1 | 1.0 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
0.1 | 2.3 | GO:0015144 | carbohydrate transmembrane transporter activity(GO:0015144) carbohydrate transporter activity(GO:1901476) |
0.0 | 0.9 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
0.0 | 0.3 | GO:0003910 | DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910) |
0.0 | 0.5 | GO:0008106 | alcohol dehydrogenase (NADP+) activity(GO:0008106) |
0.0 | 0.5 | GO:0045503 | dynein light chain binding(GO:0045503) |
0.0 | 0.5 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
0.0 | 0.5 | GO:0036312 | phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312) |
0.0 | 0.7 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
0.0 | 0.8 | GO:0071837 | HMG box domain binding(GO:0071837) |
0.0 | 0.7 | GO:0017025 | TBP-class protein binding(GO:0017025) |
0.0 | 0.7 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
0.0 | 0.1 | GO:0008853 | exodeoxyribonuclease III activity(GO:0008853) |
0.0 | 0.1 | GO:0060072 | large conductance calcium-activated potassium channel activity(GO:0060072) |
0.0 | 0.9 | GO:0016776 | phosphotransferase activity, phosphate group as acceptor(GO:0016776) |
0.0 | 0.5 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
0.0 | 0.4 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
0.0 | 0.4 | GO:0017091 | AU-rich element binding(GO:0017091) |
0.0 | 1.3 | GO:1902936 | phosphatidylinositol bisphosphate binding(GO:1902936) |
0.0 | 2.3 | GO:0001047 | core promoter binding(GO:0001047) |
0.0 | 0.1 | GO:0051429 | corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 3.8 | SA_G1_AND_S_PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
0.1 | 2.7 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
0.1 | 2.5 | PID_ARF6_PATHWAY | Arf6 signaling events |
0.0 | 0.7 | SA_PROGRAMMED_CELL_DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
0.0 | 0.4 | PID_VEGF_VEGFR_PATHWAY | VEGF and VEGFR signaling network |
0.0 | 0.6 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
0.0 | 1.6 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
0.0 | 1.8 | PID_FGF_PATHWAY | FGF signaling pathway |
0.0 | 1.3 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
0.0 | 0.7 | PID_ILK_PATHWAY | Integrin-linked kinase signaling |
0.0 | 0.5 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
0.0 | 1.4 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
0.0 | 0.3 | PID_DNA_PK_PATHWAY | DNA-PK pathway in nonhomologous end joining |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 2.6 | REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
0.2 | 2.5 | REACTOME_ACTIVATION_OF_RAC | Genes involved in Activation of Rac |
0.1 | 3.8 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
0.1 | 1.0 | REACTOME_GLUCURONIDATION | Genes involved in Glucuronidation |
0.1 | 1.3 | REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
0.1 | 2.1 | REACTOME_METAL_ION_SLC_TRANSPORTERS | Genes involved in Metal ion SLC transporters |
0.1 | 1.2 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
0.1 | 0.5 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
0.1 | 2.1 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
0.0 | 2.9 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT | Genes involved in Respiratory electron transport |
0.0 | 1.3 | REACTOME_SYNTHESIS_OF_PA | Genes involved in Synthesis of PA |
0.0 | 0.7 | REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION | Genes involved in Sema3A PAK dependent Axon repulsion |
0.0 | 1.0 | REACTOME_KINESINS | Genes involved in Kinesins |
0.0 | 0.7 | REACTOME_N_GLYCAN_ANTENNAE_ELONGATION | Genes involved in N-Glycan antennae elongation |
0.0 | 0.4 | REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
0.0 | 0.9 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
0.0 | 0.4 | REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
0.0 | 1.8 | REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
0.0 | 0.7 | REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
0.0 | 0.6 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
0.0 | 0.3 | REACTOME_INTEGRATION_OF_PROVIRUS | Genes involved in Integration of provirus |
0.0 | 0.7 | REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
0.0 | 0.2 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
0.0 | 1.4 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
0.0 | 1.5 | REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION | Genes involved in Influenza Viral RNA Transcription and Replication |
0.0 | 0.3 | REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
0.0 | 1.8 | REACTOME_SIGNALING_BY_FGFR | Genes involved in Signaling by FGFR |
0.0 | 0.2 | REACTOME_RNA_POL_I_PROMOTER_OPENING | Genes involved in RNA Polymerase I Promoter Opening |