Motif ID: Hoxa10

Z-value: 0.813


Transcription factors associated with Hoxa10:

Gene SymbolEntrez IDGene Name
Hoxa10 ENSMUSG00000000938.11 Hoxa10



Activity profile for motif Hoxa10.

activity profile for motif Hoxa10


Sorted Z-values histogram for motif Hoxa10

Sorted Z-values for motif Hoxa10



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa10

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_34354119 5.469 ENSMUST00000038406.6
Akr1b8
aldo-keto reductase family 1, member B8
chr8_+_106935720 5.165 ENSMUST00000047425.3
Sntb2
syntrophin, basic 2
chr17_+_29093763 4.532 ENSMUST00000023829.6
Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr3_+_102010138 4.110 ENSMUST00000066187.4
Nhlh2
nescient helix loop helix 2
chr11_+_44617310 3.787 ENSMUST00000081265.5
ENSMUST00000101326.3
ENSMUST00000109268.1
Ebf1


early B cell factor 1


chr2_+_102658640 3.278 ENSMUST00000080210.3
Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr2_-_79908428 2.503 ENSMUST00000102652.3
ENSMUST00000102651.3
Pde1a

phosphodiesterase 1A, calmodulin-dependent

chr11_-_78984831 2.499 ENSMUST00000073001.4
ENSMUST00000108269.3
Lgals9

lectin, galactose binding, soluble 9

chr8_+_58912257 2.377 ENSMUST00000160055.1
BC030500
cDNA sequence BC030500
chr1_+_66321708 2.190 ENSMUST00000114013.1
Map2
microtubule-associated protein 2
chr10_-_11082287 2.094 ENSMUST00000105561.2
ENSMUST00000044306.6
Grm1

glutamate receptor, metabotropic 1

chr11_-_78984946 2.046 ENSMUST00000108268.3
Lgals9
lectin, galactose binding, soluble 9
chrX_+_56609843 1.879 ENSMUST00000077741.5
ENSMUST00000114784.2
Slc9a6

solute carrier family 9 (sodium/hydrogen exchanger), member 6

chr2_-_79908389 1.752 ENSMUST00000090756.4
Pde1a
phosphodiesterase 1A, calmodulin-dependent
chr11_-_42000284 1.600 ENSMUST00000109292.2
ENSMUST00000109290.1
Gabrg2

gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2

chr11_-_69822144 1.548 ENSMUST00000045771.6
Spem1
sperm maturation 1
chr13_+_24614608 1.404 ENSMUST00000091694.3
Fam65b
family with sequence similarity 65, member B
chr2_+_68117713 1.402 ENSMUST00000112346.2
B3galt1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chrX_-_43274786 1.372 ENSMUST00000016294.7
Tenm1
teneurin transmembrane protein 1
chr2_-_37647199 1.343 ENSMUST00000028279.3
Strbp
spermatid perinuclear RNA binding protein
chr1_+_74713551 1.329 ENSMUST00000027356.5
Cyp27a1
cytochrome P450, family 27, subfamily a, polypeptide 1
chr5_-_103100054 1.316 ENSMUST00000112848.1
Mapk10
mitogen-activated protein kinase 10
chr6_-_56901870 1.307 ENSMUST00000101367.2
Nt5c3
5'-nucleotidase, cytosolic III
chr2_+_61578549 1.306 ENSMUST00000112502.1
ENSMUST00000078074.2
Tank

TRAF family member-associated Nf-kappa B activator

chr9_-_50739365 1.276 ENSMUST00000117093.1
ENSMUST00000121634.1
Dixdc1

DIX domain containing 1

chr1_-_89933290 1.237 ENSMUST00000036954.7
Gbx2
gastrulation brain homeobox 2
chr8_+_12984246 1.210 ENSMUST00000110873.3
ENSMUST00000173006.1
ENSMUST00000145067.1
Mcf2l


mcf.2 transforming sequence-like


chr3_-_123672321 1.171 ENSMUST00000172537.1
ENSMUST00000029602.6
Ndst3

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3

chr9_-_39604124 1.136 ENSMUST00000042485.4
ENSMUST00000141370.1
AW551984

expressed sequence AW551984

chr11_+_87109221 1.121 ENSMUST00000020794.5
Ska2
spindle and kinetochore associated complex subunit 2
chr13_-_99516537 1.116 ENSMUST00000064762.4
Map1b
microtubule-associated protein 1B
chr4_-_119383732 1.095 ENSMUST00000044781.2
ENSMUST00000084307.3
Ccdc30

coiled-coil domain containing 30

chr18_+_33464163 1.075 ENSMUST00000097634.3
Gm10549
predicted gene 10549
chr1_-_140183404 0.997 ENSMUST00000066859.6
ENSMUST00000111976.2
Cfh

complement component factor h

chr1_-_156939626 0.982 ENSMUST00000063199.6
ENSMUST00000027886.7
ENSMUST00000172057.1
Ralgps2


Ral GEF with PH domain and SH3 binding motif 2


chr10_+_97565436 0.975 ENSMUST00000038160.4
Lum
lumican
chr6_+_54264839 0.952 ENSMUST00000146114.1
Chn2
chimerin (chimaerin) 2
chr2_+_15049395 0.909 ENSMUST00000017562.6
Arl5b
ADP-ribosylation factor-like 5B
chr6_-_3494587 0.901 ENSMUST00000049985.8
Hepacam2
HEPACAM family member 2
chr1_-_140183283 0.886 ENSMUST00000111977.1
Cfh
complement component factor h
chr9_+_53771499 0.843 ENSMUST00000048670.8
Slc35f2
solute carrier family 35, member F2
chrX_+_112604274 0.836 ENSMUST00000071814.6
Zfp711
zinc finger protein 711
chr5_-_123666682 0.815 ENSMUST00000149410.1
Clip1
CAP-GLY domain containing linker protein 1
chr3_+_85915722 0.781 ENSMUST00000054148.7
Gm9790
predicted gene 9790
chr16_+_44394771 0.773 ENSMUST00000099742.2
Wdr52
WD repeat domain 52
chr2_-_73625731 0.764 ENSMUST00000070579.6
Chn1
chimerin (chimaerin) 1
chrX_-_136741155 0.731 ENSMUST00000166930.1
ENSMUST00000113095.1
ENSMUST00000155207.1
ENSMUST00000080411.6
ENSMUST00000169418.1
Morf4l2




mortality factor 4 like 2




chr4_-_109202217 0.729 ENSMUST00000160774.1
ENSMUST00000030288.7
ENSMUST00000162787.2
Osbpl9


oxysterol binding protein-like 9


chr18_+_37411674 0.715 ENSMUST00000051126.2
Pcdhb10
protocadherin beta 10
chr4_+_43406435 0.675 ENSMUST00000098106.2
ENSMUST00000139198.1
Rusc2

RUN and SH3 domain containing 2

chr9_-_96478660 0.675 ENSMUST00000057500.4
Rnf7
ring finger protein 7
chr7_-_126160992 0.669 ENSMUST00000164741.1
Xpo6
exportin 6
chr3_-_94436574 0.668 ENSMUST00000029787.4
Oaz3
ornithine decarboxylase antizyme 3
chr17_-_6079693 0.653 ENSMUST00000024570.5
ENSMUST00000097432.3
Serac1

serine active site containing 1

chr3_+_60877002 0.653 ENSMUST00000099086.2
Gm8325
predicted pseudogene 8325
chr7_-_25882407 0.652 ENSMUST00000163316.2
Gm6434
predicted gene 6434
chr6_+_6955993 0.648 ENSMUST00000040826.5
Acn9
ACN9 homolog (S. cerevisiae)
chrM_+_14138 0.646 ENSMUST00000082421.1
mt-Cytb
mitochondrially encoded cytochrome b
chr17_-_15566421 0.641 ENSMUST00000178455.1
Gm6686
predicted pseudogene 6686
chr4_-_91376433 0.640 ENSMUST00000107109.2
ENSMUST00000107111.2
ENSMUST00000107120.1
Elavl2


ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)


chr19_+_4711153 0.639 ENSMUST00000008991.6
Sptbn2
spectrin beta, non-erythrocytic 2
chr2_-_34755229 0.634 ENSMUST00000102800.1
Gapvd1
GTPase activating protein and VPS9 domains 1
chr19_+_24875679 0.630 ENSMUST00000073080.5
Gm10053
predicted gene 10053
chr9_-_119825456 0.628 ENSMUST00000070617.7
Scn11a
sodium channel, voltage-gated, type XI, alpha
chr5_+_121777929 0.626 ENSMUST00000160821.1
Atxn2
ataxin 2
chr1_+_167618246 0.607 ENSMUST00000111380.1
Rxrg
retinoid X receptor gamma
chr5_+_121749196 0.600 ENSMUST00000161064.1
Atxn2
ataxin 2
chr1_-_156718989 0.582 ENSMUST00000122424.1
Fam20b
family with sequence similarity 20, member B
chr8_-_54718664 0.564 ENSMUST00000144711.2
ENSMUST00000093510.2
Wdr17

WD repeat domain 17

chr7_+_51880312 0.548 ENSMUST00000145049.1
Gas2
growth arrest specific 2
chr8_-_33747724 0.544 ENSMUST00000179364.1
Smim18
small integral membrane protein 18
chr5_-_131616599 0.540 ENSMUST00000161804.1
Auts2
autism susceptibility candidate 2
chr2_+_83812567 0.540 ENSMUST00000051454.3
Fam171b
family with sequence similarity 171, member B
chr19_+_43440404 0.539 ENSMUST00000165311.1
Cnnm1
cyclin M1
chr13_+_44840686 0.527 ENSMUST00000173906.1
Jarid2
jumonji, AT rich interactive domain 2
chrM_+_3906 0.507 ENSMUST00000082396.1
mt-Nd2
mitochondrially encoded NADH dehydrogenase 2
chr12_+_55089202 0.497 ENSMUST00000021407.10
Srp54a
signal recognition particle 54A
chr5_+_121802230 0.477 ENSMUST00000162995.1
Atxn2
ataxin 2
chr9_-_112232449 0.474 ENSMUST00000035085.5
Arpp21
cyclic AMP-regulated phosphoprotein, 21
chr1_+_193173469 0.472 ENSMUST00000161235.1
ENSMUST00000110831.2
ENSMUST00000178744.1
A130010J15Rik


RIKEN cDNA A130010J15 gene


chr1_-_125913101 0.463 ENSMUST00000161361.1
Lypd1
Ly6/Plaur domain containing 1
chr8_-_41054771 0.463 ENSMUST00000093534.4
Mtus1
mitochondrial tumor suppressor 1
chr5_-_118244861 0.458 ENSMUST00000117177.1
ENSMUST00000133372.1
ENSMUST00000154786.1
ENSMUST00000121369.1
Rnft2



ring finger protein, transmembrane 2



chr10_-_29362012 0.457 ENSMUST00000161508.1
Rnf146
ring finger protein 146
chr1_-_156718894 0.450 ENSMUST00000086153.6
Fam20b
family with sequence similarity 20, member B
chr9_-_46319984 0.447 ENSMUST00000159565.1
4931429L15Rik
RIKEN cDNA 4931429L15 gene
chr13_+_18717289 0.438 ENSMUST00000072961.4
Vps41
vacuolar protein sorting 41 (yeast)
chr16_-_35871544 0.432 ENSMUST00000042665.8
Parp14
poly (ADP-ribose) polymerase family, member 14
chr10_-_29144194 0.411 ENSMUST00000070359.2
Gm9996
predicted gene 9996
chr9_+_58582397 0.403 ENSMUST00000176557.1
ENSMUST00000114121.4
ENSMUST00000177064.1
Nptn


neuroplastin


chr2_+_69790968 0.395 ENSMUST00000180290.1
Phospho2
phosphatase, orphan 2
chrX_+_96455359 0.395 ENSMUST00000033553.7
Heph
hephaestin
chr12_+_55239326 0.387 ENSMUST00000164243.1
Srp54c
signal recognition particle 54C
chr9_-_86464944 0.375 ENSMUST00000034986.7
Ube2cbp
ubiquitin-conjugating enzyme E2C binding protein
chr7_-_144470714 0.370 ENSMUST00000033407.6
Cttn
cortactin
chr12_+_10390756 0.360 ENSMUST00000020947.5
Rdh14
retinol dehydrogenase 14 (all-trans and 9-cis)
chr8_+_46986913 0.360 ENSMUST00000039840.7
ENSMUST00000119686.1
Enpp6

ectonucleotide pyrophosphatase/phosphodiesterase 6

chr18_+_37513652 0.349 ENSMUST00000061405.4
Pcdhb21
protocadherin beta 21
chr9_+_62342449 0.341 ENSMUST00000156461.1
Anp32a
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
chr1_+_179960472 0.324 ENSMUST00000097453.2
ENSMUST00000111117.1
Cdc42bpa

CDC42 binding protein kinase alpha

chr10_-_128180265 0.323 ENSMUST00000099139.1
Rbms2
RNA binding motif, single stranded interacting protein 2
chr2_-_114201416 0.319 ENSMUST00000050668.3
Zfp770
zinc finger protein 770
chr11_-_110168073 0.298 ENSMUST00000044850.3
Abca9
ATP-binding cassette, sub-family A (ABC1), member 9
chr10_-_116549101 0.292 ENSMUST00000164088.1
Cnot2
CCR4-NOT transcription complex, subunit 2
chr2_-_149798701 0.291 ENSMUST00000148202.1
ENSMUST00000139471.1
Gm14133

predicted gene 14133

chr3_-_59262825 0.278 ENSMUST00000050360.7
P2ry12
purinergic receptor P2Y, G-protein coupled 12
chr1_+_127729405 0.277 ENSMUST00000038006.6
Acmsd
amino carboxymuconate semialdehyde decarboxylase
chr9_-_96478596 0.265 ENSMUST00000071301.4
Rnf7
ring finger protein 7
chr4_+_42629719 0.257 ENSMUST00000166898.2
Gm2564
predicted gene 2564
chr2_-_51149100 0.248 ENSMUST00000154545.1
ENSMUST00000017288.2
Rnd3

Rho family GTPase 3

chr18_-_3281712 0.245 ENSMUST00000182204.1
ENSMUST00000154705.1
ENSMUST00000182833.1
ENSMUST00000151084.1
Crem



cAMP responsive element modulator



chr9_-_100506844 0.233 ENSMUST00000112874.3
Nck1
non-catalytic region of tyrosine kinase adaptor protein 1
chr11_+_87582201 0.231 ENSMUST00000133202.1
Sept4
septin 4
chrX_+_112615301 0.223 ENSMUST00000122805.1
Zfp711
zinc finger protein 711
chr2_+_164823001 0.223 ENSMUST00000132282.1
Zswim1
zinc finger SWIM-type containing 1
chr3_+_136670076 0.212 ENSMUST00000070198.7
Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chr1_+_179961110 0.212 ENSMUST00000076687.5
ENSMUST00000097450.3
Cdc42bpa

CDC42 binding protein kinase alpha

chr18_-_43477764 0.195 ENSMUST00000057110.9
Eif3j2
eukaryotic translation initiation factor 3, subunit J2
chr18_-_23038656 0.190 ENSMUST00000081423.6
Nol4
nucleolar protein 4
chr1_+_182124737 0.187 ENSMUST00000111018.1
ENSMUST00000027792.5
Srp9

signal recognition particle 9

chr8_+_110618577 0.166 ENSMUST00000034190.9
Vac14
Vac14 homolog (S. cerevisiae)
chr17_+_33824591 0.162 ENSMUST00000048249.6
Ndufa7
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7 (B14.5a)
chr10_-_111997204 0.159 ENSMUST00000074805.5
Glipr1
GLI pathogenesis-related 1 (glioma)
chr5_+_64160207 0.137 ENSMUST00000101195.2
Tbc1d1
TBC1 domain family, member 1
chr11_-_83645621 0.137 ENSMUST00000182502.1
Rpl9-ps1
ribosomal protein L9, pseudogene 1
chr17_+_36958623 0.137 ENSMUST00000173814.1
Znrd1as
Znrd1 antisense
chr14_+_54686171 0.136 ENSMUST00000038539.6
1700123O20Rik
RIKEN cDNA 1700123O20 gene
chr6_+_127453667 0.129 ENSMUST00000112193.1
Parp11
poly (ADP-ribose) polymerase family, member 11
chr17_+_6079786 0.115 ENSMUST00000039487.3
Gtf2h5
general transcription factor IIH, polypeptide 5
chr1_+_59684949 0.109 ENSMUST00000027174.3
Nop58
NOP58 ribonucleoprotein
chr8_-_105565985 0.104 ENSMUST00000013304.7
Atp6v0d1
ATPase, H+ transporting, lysosomal V0 subunit D1
chr1_+_153874335 0.103 ENSMUST00000055314.3
Gm5531
predicted gene 5531
chr13_-_60897439 0.101 ENSMUST00000171347.1
ENSMUST00000021884.8
Ctla2b

cytotoxic T lymphocyte-associated protein 2 beta

chr10_+_29143996 0.093 ENSMUST00000092629.2
Soga3
SOGA family member 3
chr6_-_24528013 0.089 ENSMUST00000023851.5
Ndufa5
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
chr2_-_77946331 0.075 ENSMUST00000111821.2
ENSMUST00000111818.1
Cwc22

CWC22 spliceosome-associated protein homolog (S. cerevisiae)

chr18_+_37518341 0.072 ENSMUST00000097609.1
Pcdhb22
protocadherin beta 22
chr16_-_91069142 0.072 ENSMUST00000035689.1
ENSMUST00000114076.1
4932438H23Rik

RIKEN cDNA 4932438H23 gene

chr9_+_55326913 0.070 ENSMUST00000085754.3
ENSMUST00000034862.4
AI118078

expressed sequence AI118078

chr16_+_48872608 0.065 ENSMUST00000065666.4
Retnlg
resistin like gamma
chr10_+_5593718 0.056 ENSMUST00000051809.8
Myct1
myc target 1
chr2_-_77946375 0.049 ENSMUST00000065889.3
Cwc22
CWC22 spliceosome-associated protein homolog (S. cerevisiae)
chr17_+_6079928 0.046 ENSMUST00000100955.2
Gtf2h5
general transcription factor IIH, polypeptide 5
chr15_+_59374198 0.031 ENSMUST00000079703.3
ENSMUST00000168722.1
Nsmce2

non-SMC element 2 homolog (MMS21, S. cerevisiae)

chr7_+_29238434 0.027 ENSMUST00000108237.1
Yif1b
Yip1 interacting factor homolog B (S. cerevisiae)
chr6_-_122856151 0.024 ENSMUST00000042081.8
C3ar1
complement component 3a receptor 1
chr17_+_36958571 0.016 ENSMUST00000040177.6
Znrd1as
Znrd1 antisense
chr4_+_115057683 0.010 ENSMUST00000161601.1
Tal1
T cell acute lymphocytic leukemia 1
chr13_-_92030897 0.005 ENSMUST00000149630.1
Rasgrf2
RAS protein-specific guanine nucleotide-releasing factor 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.5 GO:0016095 polyprenol catabolic process(GO:0016095) terpenoid catabolic process(GO:0016115) primary alcohol catabolic process(GO:0034310)
1.5 4.5 GO:1902714 negative regulation of interferon-gamma secretion(GO:1902714)
0.5 2.1 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.5 4.5 GO:0071493 cellular response to UV-B(GO:0071493)
0.5 3.3 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.3 1.3 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.3 1.9 GO:0045919 complement activation, alternative pathway(GO:0006957) positive regulation of cytolysis(GO:0045919)
0.2 1.0 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.2 4.3 GO:0046069 cGMP catabolic process(GO:0046069)
0.2 1.3 GO:0007258 JUN phosphorylation(GO:0007258)
0.2 1.9 GO:0031547 brain-derived neurotrophic factor receptor signaling pathway(GO:0031547)
0.2 0.8 GO:0044861 protein transport into plasma membrane raft(GO:0044861)
0.2 1.0 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)
0.2 1.2 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.2 0.5 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
0.2 1.6 GO:0071420 cellular response to histamine(GO:0071420)
0.2 1.2 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.2 0.7 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.2 1.1 GO:0060923 cardiac muscle cell fate commitment(GO:0060923)
0.2 1.4 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.1 4.1 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.1 1.3 GO:0046085 adenosine metabolic process(GO:0046085)
0.1 0.6 GO:0033762 response to glucagon(GO:0033762)
0.1 0.4 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.1 2.0 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.1 1.3 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.1 0.3 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.1 0.3 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.1 0.4 GO:1902774 late endosome to lysosome transport(GO:1902774)
0.1 0.4 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.1 0.9 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
0.1 0.2 GO:0002191 cap-dependent translational initiation(GO:0002191)
0.1 3.3 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.1 0.2 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244) regulation of connective tissue replacement(GO:1905203)
0.1 0.4 GO:0019695 choline metabolic process(GO:0019695)
0.0 0.4 GO:0006930 substrate-dependent cell migration, cell extension(GO:0006930)
0.0 0.7 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 1.3 GO:0007638 mechanosensory behavior(GO:0007638)
0.0 0.5 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.0 1.2 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 0.4 GO:0042572 retinol metabolic process(GO:0042572)
0.0 0.2 GO:0030382 sperm mitochondrion organization(GO:0030382)
0.0 1.4 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 1.5 GO:0030317 sperm motility(GO:0030317)
0.0 0.6 GO:0021692 cerebellar Purkinje cell layer morphogenesis(GO:0021692)
0.0 0.5 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.5 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.0 0.1 GO:0002408 myeloid dendritic cell chemotaxis(GO:0002408)
0.0 0.4 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.8 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 0.5 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.0 0.6 GO:0051930 regulation of sensory perception of pain(GO:0051930) regulation of sensory perception(GO:0051931)
0.0 0.6 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 0.1 GO:0048254 snoRNA localization(GO:0048254)
0.0 0.4 GO:0006825 copper ion transport(GO:0006825)
0.0 0.2 GO:0006362 transcription elongation from RNA polymerase I promoter(GO:0006362)
0.0 0.6 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.0 0.5 GO:1903077 negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.0 0.8 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 1.0 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.0 1.3 GO:0008203 cholesterol metabolic process(GO:0008203)
0.0 0.0 GO:0034184 positive regulation of maintenance of sister chromatid cohesion(GO:0034093) positive regulation of maintenance of mitotic sister chromatid cohesion(GO:0034184)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.5 GO:0070557 PCNA-p21 complex(GO:0070557)
0.3 0.9 GO:0043224 nuclear SCF ubiquitin ligase complex(GO:0043224)
0.3 1.9 GO:0044308 axonal spine(GO:0044308)
0.2 2.2 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.2 0.6 GO:0044299 C-fiber(GO:0044299)
0.2 2.1 GO:0038037 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
0.1 0.8 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.1 1.6 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1 0.6 GO:0008091 spectrin(GO:0008091)
0.1 3.3 GO:0030673 axolemma(GO:0030673)
0.1 1.1 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 0.7 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.1 1.0 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 1.1 GO:0043196 varicosity(GO:0043196)
0.1 0.4 GO:0033263 CORVET complex(GO:0033263)
0.1 0.6 GO:0045275 respiratory chain complex III(GO:0045275)
0.0 0.3 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.2 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.1 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.0 0.4 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 0.2 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.0 2.6 GO:0072562 blood microparticle(GO:0072562)
0.0 0.2 GO:0097227 sperm annulus(GO:0097227)
0.0 0.5 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 1.7 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.5 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 1.0 GO:0045202 synapse(GO:0045202)
0.0 0.2 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.2 GO:0000439 core TFIIH complex(GO:0000439)
0.0 0.1 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.2 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 1.3 GO:0043204 perikaryon(GO:0043204)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.5 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
1.1 5.5 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.8 4.5 GO:0016936 galactoside binding(GO:0016936)
0.6 4.3 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.5 3.3 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.5 2.1 GO:0001639 PLC activating G-protein coupled glutamate receptor activity(GO:0001639) G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.5 1.9 GO:0001851 complement component C3b binding(GO:0001851)
0.4 3.3 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.4 1.4 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.3 1.3 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.3 1.3 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.3 1.2 GO:0042328 heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328)
0.3 3.8 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.2 1.9 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.2 0.7 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.2 1.3 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.1 0.9 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.1 1.7 GO:0050692 DBD domain binding(GO:0050692)
0.1 0.6 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 0.5 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.1 0.4 GO:0033883 pyridoxal phosphatase activity(GO:0033883)
0.1 1.6 GO:0004890 GABA-A receptor activity(GO:0004890)
0.1 1.3 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.1 0.6 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 0.4 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 1.2 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 4.1 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 0.2 GO:0008312 7S RNA binding(GO:0008312)
0.1 0.5 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.1 0.4 GO:0008106 alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.0 0.8 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.4 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0 0.3 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.0 0.3 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.2 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0 1.3 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 0.2 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.4 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.4 GO:0070403 NAD+ binding(GO:0070403)
0.0 0.6 GO:0005248 voltage-gated sodium channel activity(GO:0005248)
0.0 1.2 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.0 0.4 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 3.9 GO:0005516 calmodulin binding(GO:0005516)
0.0 1.3 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.7 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 1.0 GO:0005518 collagen binding(GO:0005518)
0.0 0.1 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.0 0.2 GO:0000182 rDNA binding(GO:0000182)
0.0 0.5 GO:0032452 histone demethylase activity(GO:0032452)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.5 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 4.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.4 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 1.0 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 2.2 PID_LKB1_PATHWAY LKB1 signaling events
0.0 0.4 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 0.2 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.6 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.5 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.6 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.4 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 0.8 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 0.2 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 1.0 PID_ERBB1_DOWNSTREAM_PATHWAY ErbB1 downstream signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.9 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.2 1.3 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.2 4.5 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.2 4.3 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.2 2.1 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 1.3 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.1 1.6 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.1 1.0 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.1 1.3 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 1.3 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 3.3 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 3.8 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.3 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.3 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism
0.0 1.2 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.5 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 1.1 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.6 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.9 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.4 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.3 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.2 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 0.7 REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0 0.3 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 0.2 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane