Motif ID: Aire

Z-value: 0.771


Transcription factors associated with Aire:

Gene SymbolEntrez IDGene Name
Aire ENSMUSG00000000731.9 Aire



Activity profile for motif Aire.

activity profile for motif Aire


Sorted Z-values histogram for motif Aire

Sorted Z-values for motif Aire



Network of associatons between targets according to the STRING database.



First level regulatory network of Aire

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_61185558 19.725 ENSMUST00000166381.1
Cdr1
cerebellar degeneration related antigen 1
chr13_-_110280103 3.547 ENSMUST00000167824.1
Rab3c
RAB3C, member RAS oncogene family
chr12_-_78983476 3.331 ENSMUST00000070174.7
Tmem229b
transmembrane protein 229B
chr3_-_116968969 3.242 ENSMUST00000143611.1
ENSMUST00000040097.7
Palmd

palmdelphin

chr16_+_36875119 3.134 ENSMUST00000135406.1
ENSMUST00000114812.1
ENSMUST00000134616.1
ENSMUST00000023534.6
Golgb1


Golgb1
golgi autoantigen, golgin subfamily b, macrogolgin 1


golgi autoantigen, golgin subfamily b, macrogolgin 1
chr19_-_28963863 2.624 ENSMUST00000161813.1
4430402I18Rik
RIKEN cDNA 4430402I18 gene
chr14_+_76476913 2.393 ENSMUST00000140251.2
Tsc22d1
TSC22 domain family, member 1
chr10_-_130280218 2.202 ENSMUST00000061571.3
Neurod4
neurogenic differentiation 4
chr8_+_69808672 2.190 ENSMUST00000036074.8
ENSMUST00000123453.1
Gmip

Gem-interacting protein

chr18_+_37400845 2.070 ENSMUST00000057228.1
Pcdhb9
protocadherin beta 9
chr9_-_97111117 1.678 ENSMUST00000085206.4
Slc25a36
solute carrier family 25, member 36
chr7_-_127895578 1.669 ENSMUST00000033074.6
Vkorc1
vitamin K epoxide reductase complex, subunit 1
chr2_-_134644079 1.640 ENSMUST00000110119.1
Tmx4
thioredoxin-related transmembrane protein 4
chr8_+_64947177 1.577 ENSMUST00000079896.7
ENSMUST00000026595.5
Tmem192

transmembrane protein 192

chr5_-_84417359 1.518 ENSMUST00000113401.1
Epha5
Eph receptor A5
chr18_+_37725706 1.502 ENSMUST00000066149.6
Pcdhga9
protocadherin gamma subfamily A, 9
chr10_+_86021961 1.374 ENSMUST00000130320.1
Fbxo7
F-box protein 7
chr8_-_4217133 1.264 ENSMUST00000175906.1
BC068157
cDNA sequence BC068157
chr5_+_43672289 1.216 ENSMUST00000156034.1
Cc2d2a
coiled-coil and C2 domain containing 2A
chr10_-_81014902 1.205 ENSMUST00000126317.1
ENSMUST00000092285.3
ENSMUST00000117805.1
Gng7


guanine nucleotide binding protein (G protein), gamma 7


chr1_+_65186727 1.183 ENSMUST00000097707.4
ENSMUST00000081154.7
Pikfyve

phosphoinositide kinase, FYVE finger containing

chr14_+_21481428 1.181 ENSMUST00000182996.1
Kat6b
K(lysine) acetyltransferase 6B
chr2_-_134644125 1.177 ENSMUST00000038228.4
Tmx4
thioredoxin-related transmembrane protein 4
chr8_-_4216912 1.155 ENSMUST00000177491.1
BC068157
cDNA sequence BC068157
chr14_-_18894255 1.119 ENSMUST00000124353.1
Ube2e2
ubiquitin-conjugating enzyme E2E 2
chr3_-_62506970 1.117 ENSMUST00000029336.4
Dhx36
DEAH (Asp-Glu-Ala-His) box polypeptide 36
chr4_-_19570073 1.114 ENSMUST00000029885.4
Cpne3
copine III
chr16_-_91618986 1.110 ENSMUST00000143058.1
ENSMUST00000049244.8
ENSMUST00000169982.1
ENSMUST00000133731.1
Dnajc28



DnaJ (Hsp40) homolog, subfamily C, member 28



chr2_+_55435918 1.101 ENSMUST00000067101.3
Kcnj3
potassium inwardly-rectifying channel, subfamily J, member 3
chr12_+_36157124 0.981 ENSMUST00000041640.3
Ankmy2
ankyrin repeat and MYND domain containing 2
chr9_-_53610329 0.935 ENSMUST00000034547.5
Acat1
acetyl-Coenzyme A acetyltransferase 1
chr2_-_165400398 0.935 ENSMUST00000029213.4
Ocstamp
osteoclast stimulatory transmembrane protein
chr11_-_69696058 0.913 ENSMUST00000094070.4
ENSMUST00000180587.1
BC096441
Tnfsf12
cDNA sequence BC096441
tumor necrosis factor (ligand) superfamily, member 12
chr3_+_89715016 0.906 ENSMUST00000098924.2
Adar
adenosine deaminase, RNA-specific
chr5_+_114896936 0.883 ENSMUST00000031542.9
ENSMUST00000146072.1
ENSMUST00000150361.1
Oasl2


2'-5' oligoadenylate synthetase-like 2


chr11_-_69695802 0.873 ENSMUST00000108649.1
ENSMUST00000174159.1
ENSMUST00000181810.1
BC096441

Tnfsf12
cDNA sequence BC096441

tumor necrosis factor (ligand) superfamily, member 12
chr15_+_101266839 0.865 ENSMUST00000023779.6
Nr4a1
nuclear receptor subfamily 4, group A, member 1
chr12_+_84052114 0.851 ENSMUST00000120927.1
Acot3
acyl-CoA thioesterase 3
chr10_+_52358767 0.824 ENSMUST00000180473.1
Gm26741
predicted gene, 26741
chr19_+_34217588 0.789 ENSMUST00000119603.1
Stambpl1
STAM binding protein like 1
chr2_+_175283298 0.780 ENSMUST00000098998.3
Gm14440
predicted gene 14440
chr11_-_115627948 0.768 ENSMUST00000154623.1
ENSMUST00000106503.3
ENSMUST00000141614.1
Slc25a19


solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19


chr17_+_35236556 0.765 ENSMUST00000068261.8
Atp6v1g2
ATPase, H+ transporting, lysosomal V1 subunit G2
chr7_+_45896941 0.761 ENSMUST00000069772.7
ENSMUST00000107716.1
Tmem143

transmembrane protein 143

chr8_+_111643425 0.761 ENSMUST00000077791.6
Zfp1
zinc finger protein 1
chr2_+_164948219 0.714 ENSMUST00000017881.2
Mmp9
matrix metallopeptidase 9
chr5_-_113310697 0.711 ENSMUST00000154248.1
Sgsm1
small G protein signaling modulator 1
chr3_-_89411781 0.705 ENSMUST00000107429.3
ENSMUST00000129308.2
ENSMUST00000107426.1
ENSMUST00000050398.4
ENSMUST00000162701.1
Flad1




RFad1, flavin adenine dinucleotide synthetase, homolog (yeast)




chr17_+_22689771 0.686 ENSMUST00000055305.8
Gm9805
predicted gene 9805
chr10_+_58446845 0.669 ENSMUST00000003310.5
Ranbp2
RAN binding protein 2
chr7_-_14562171 0.647 ENSMUST00000181796.1
Vmn1r90
vomeronasal 1 receptor 90
chr2_+_176431829 0.629 ENSMUST00000172025.1
Gm14435
predicted gene 14435
chr5_+_130369420 0.619 ENSMUST00000086029.3
Caln1
calneuron 1
chr5_+_24100578 0.599 ENSMUST00000030841.5
ENSMUST00000163409.1
Klhl7

kelch-like 7

chr8_-_109962127 0.582 ENSMUST00000001722.7
ENSMUST00000051430.6
Marveld3

MARVEL (membrane-associating) domain containing 3

chr12_-_36156781 0.578 ENSMUST00000020856.4
Bzw2
basic leucine zipper and W2 domains 2
chr1_+_44119952 0.572 ENSMUST00000114709.2
Bivm
basic, immunoglobulin-like variable motif containing
chr14_+_124005355 0.570 ENSMUST00000166105.1
Gm17615
predicted gene, 17615
chr11_+_105975204 0.567 ENSMUST00000001964.7
Ace
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
chrM_+_11734 0.539 ENSMUST00000082418.1
mt-Nd5
mitochondrially encoded NADH dehydrogenase 5
chr1_-_90843916 0.529 ENSMUST00000130846.2
ENSMUST00000097653.4
ENSMUST00000056925.9
Col6a3


collagen, type VI, alpha 3


chr17_-_6961156 0.495 ENSMUST00000063683.6
Tagap1
T cell activation GTPase activating protein 1
chrX_-_38576166 0.489 ENSMUST00000050083.5
Cul4b
cullin 4B
chr2_+_172248492 0.473 ENSMUST00000038532.1
Mc3r
melanocortin 3 receptor
chr7_+_45897429 0.467 ENSMUST00000140243.1
Tmem143
transmembrane protein 143
chr13_-_62371936 0.467 ENSMUST00000107989.3
Gm3604
predicted gene 3604
chr4_+_154869585 0.401 ENSMUST00000079269.7
ENSMUST00000163732.1
ENSMUST00000080559.6
Mmel1


membrane metallo-endopeptidase-like 1


chr2_-_121473993 0.400 ENSMUST00000056732.3
Mfap1b
microfibrillar-associated protein 1B
chr5_+_29378604 0.388 ENSMUST00000181005.1
4632411P08Rik
RIKEN cDNA 4632411P08 gene
chr4_+_11758147 0.387 ENSMUST00000029871.5
ENSMUST00000108303.1
Cdh17

cadherin 17

chrM_+_14138 0.361 ENSMUST00000082421.1
mt-Cytb
mitochondrially encoded cytochrome b
chr9_-_108263706 0.360 ENSMUST00000171412.1
Dag1
dystroglycan 1
chr10_+_123264076 0.358 ENSMUST00000050756.7
Fam19a2
family with sequence similarity 19, member A2
chr8_-_31739763 0.341 ENSMUST00000178878.1
Gm5117
predicted gene 5117
chr16_-_36874806 0.329 ENSMUST00000075946.5
Eaf2
ELL associated factor 2
chr8_-_4217261 0.327 ENSMUST00000168386.2
BC068157
cDNA sequence BC068157
chr7_-_126922887 0.317 ENSMUST00000134134.1
ENSMUST00000119781.1
ENSMUST00000121612.2
Tmem219


transmembrane protein 219


chr7_-_141434532 0.311 ENSMUST00000133021.1
ENSMUST00000106007.3
ENSMUST00000150026.1
ENSMUST00000133206.2
Slc25a22



solute carrier family 25 (mitochondrial carrier, glutamate), member 22



chr7_-_103741322 0.294 ENSMUST00000051346.2
Olfr629
olfactory receptor 629
chr1_-_171059390 0.293 ENSMUST00000164044.1
ENSMUST00000169017.1
Fcgr3

Fc receptor, IgG, low affinity III

chr13_+_49504774 0.292 ENSMUST00000051504.7
Ecm2
extracellular matrix protein 2, female organ and adipocyte specific
chr3_+_88835231 0.276 ENSMUST00000107498.2
Gon4l
gon-4-like (C.elegans)
chr19_-_4191035 0.257 ENSMUST00000045864.2
Tbc1d10c
TBC1 domain family, member 10c
chr6_+_126939957 0.257 ENSMUST00000032497.3
D6Wsu163e
DNA segment, Chr 6, Wayne State University 163, expressed
chrX_-_38576189 0.227 ENSMUST00000115118.1
Cul4b
cullin 4B
chr12_-_104865076 0.214 ENSMUST00000109937.1
ENSMUST00000109936.1
Clmn

calmin

chr5_+_121660528 0.210 ENSMUST00000031414.8
Brap
BRCA1 associated protein
chr15_+_10981747 0.207 ENSMUST00000070877.5
Amacr
alpha-methylacyl-CoA racemase
chr4_-_46566432 0.195 ENSMUST00000030021.7
ENSMUST00000107757.1
Coro2a

coronin, actin binding protein 2A

chr12_+_69296676 0.186 ENSMUST00000021362.4
Klhdc2
kelch domain containing 2
chr7_-_19665005 0.183 ENSMUST00000055242.9
Clptm1
cleft lip and palate associated transmembrane protein 1
chr2_-_94010729 0.170 ENSMUST00000040005.6
ENSMUST00000126378.1
Alkbh3

alkB, alkylation repair homolog 3 (E. coli)

chr12_+_4843303 0.167 ENSMUST00000053034.4
BC068281
cDNA sequence BC068281
chr11_-_67052563 0.137 ENSMUST00000116363.1
Adprm
ADP-ribose/CDP-alcohol diphosphatase, manganese dependent
chr9_-_113708209 0.131 ENSMUST00000111861.3
ENSMUST00000035086.6
Pdcd6ip

programmed cell death 6 interacting protein

chr6_-_148896150 0.094 ENSMUST00000072324.5
ENSMUST00000111569.2
Caprin2

caprin family member 2

chr7_-_121981669 0.091 ENSMUST00000057576.7
Cog7
component of oligomeric golgi complex 7
chr10_+_53337686 0.088 ENSMUST00000046221.6
ENSMUST00000163319.1
Pln

phospholamban

chr7_+_60155538 0.080 ENSMUST00000057611.4
Gm7367
predicted pseudogene 7367
chrM_+_7759 0.064 ENSMUST00000082407.1
ENSMUST00000082408.1
mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr2_-_134644019 0.050 ENSMUST00000110120.1
Tmx4
thioredoxin-related transmembrane protein 4
chr4_+_42714926 0.037 ENSMUST00000178454.1
Gm21955
predicted gene, 21955
chr11_+_67052641 0.023 ENSMUST00000108690.3
ENSMUST00000092996.4
Sco1

SCO cytochrome oxidase deficient homolog 1 (yeast)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.4 1.7 GO:0072531 pyrimidine-containing compound transmembrane transport(GO:0072531)
0.3 0.9 GO:0006550 isoleucine catabolic process(GO:0006550) acetyl-CoA catabolic process(GO:0046356) ketone body catabolic process(GO:0046952)
0.3 0.9 GO:0034241 positive regulation of macrophage fusion(GO:0034241) regulation of osteoclast proliferation(GO:0090289)
0.3 0.9 GO:1900369 negative regulation of RNA interference(GO:1900369)
0.3 1.1 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.3 0.8 GO:0030974 thiamine pyrophosphate transport(GO:0030974)
0.2 0.7 GO:0042726 flavin-containing compound metabolic process(GO:0042726)
0.2 1.1 GO:0090669 telomerase RNA stabilization(GO:0090669)
0.2 0.7 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.2 0.9 GO:0032788 saturated monocarboxylic acid metabolic process(GO:0032788) unsaturated monocarboxylic acid metabolic process(GO:0032789)
0.2 1.2 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.2 0.6 GO:2000170 positive regulation of peptidyl-cysteine S-nitrosylation(GO:2000170)
0.2 0.9 GO:0071376 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.2 1.4 GO:1903207 neuron death in response to hydrogen peroxide(GO:0036476) regulation of hydrogen peroxide-induced neuron death(GO:1903207) negative regulation of hydrogen peroxide-induced neuron death(GO:1903208)
0.2 2.2 GO:0035881 amacrine cell differentiation(GO:0035881)
0.2 1.1 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.2 1.5 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.1 0.7 GO:2001268 positive regulation of receptor binding(GO:1900122) negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001268)
0.1 1.1 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.1 0.4 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.1 1.2 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1 0.3 GO:0001803 antibody-dependent cellular cytotoxicity(GO:0001788) type III hypersensitivity(GO:0001802) regulation of type III hypersensitivity(GO:0001803) positive regulation of type III hypersensitivity(GO:0001805)
0.1 0.4 GO:0016340 calcium-dependent cell-matrix adhesion(GO:0016340)
0.1 1.1 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.1 0.4 GO:0033762 response to glucagon(GO:0033762)
0.1 0.6 GO:1902414 protein localization to cell junction(GO:1902414)
0.0 1.2 GO:0032288 myelin assembly(GO:0032288)
0.0 0.6 GO:0070914 UV-damage excision repair(GO:0070914)
0.0 0.1 GO:0044837 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
0.0 2.9 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 3.5 GO:0019882 antigen processing and presentation(GO:0019882)
0.0 0.3 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0 0.1 GO:0035552 oxidative single-stranded DNA demethylation(GO:0035552) oxidative single-stranded RNA demethylation(GO:0035553)
0.0 0.3 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.0 0.2 GO:0008300 isoprenoid catabolic process(GO:0008300)
0.0 1.8 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway(GO:2001238)
0.0 0.5 GO:0045475 locomotor rhythm(GO:0045475)
0.0 3.2 GO:0008360 regulation of cell shape(GO:0008360)
0.0 0.9 GO:0007606 sensory perception of chemical stimulus(GO:0007606)
0.0 2.1 GO:0007416 synapse assembly(GO:0007416)
0.0 1.0 GO:0008589 regulation of smoothened signaling pathway(GO:0008589)
0.0 0.3 GO:0015813 L-glutamate transport(GO:0015813)
0.0 0.3 GO:0033006 regulation of mast cell activation involved in immune response(GO:0033006) regulation of mast cell degranulation(GO:0043304)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:1990037 Lewy body core(GO:1990037)
0.2 0.9 GO:0044530 supraspliceosomal complex(GO:0044530)
0.1 0.7 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.1 1.2 GO:0017119 Golgi transport complex(GO:0017119)
0.1 1.2 GO:0036038 MKS complex(GO:0036038)
0.1 1.2 GO:0032593 insulin-responsive compartment(GO:0032593)
0.1 3.1 GO:0005801 cis-Golgi network(GO:0005801)
0.1 0.4 GO:0016011 dystroglycan complex(GO:0016011)
0.0 0.3 GO:0031527 filopodium membrane(GO:0031527)
0.0 0.8 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0 1.1 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.4 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.6 GO:0097225 sperm midpiece(GO:0097225)
0.0 1.2 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.6 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.3 GO:0005614 interstitial matrix(GO:0005614)
0.0 3.2 GO:0043197 dendritic spine(GO:0043197)
0.0 1.5 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 1.2 GO:0000786 nucleosome(GO:0000786)
0.0 3.5 GO:0008021 synaptic vesicle(GO:0008021)
0.0 1.1 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.1 GO:0090543 Flemming body(GO:0090543)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0003692 left-handed Z-DNA binding(GO:0003692)
0.2 1.1 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.2 1.5 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.2 1.1 GO:0042296 ISG15 transferase activity(GO:0042296)
0.2 1.1 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.2 0.5 GO:0004980 melanocortin receptor activity(GO:0004977) melanocyte-stimulating hormone receptor activity(GO:0004980)
0.2 0.9 GO:0016453 acetyl-CoA C-acetyltransferase activity(GO:0003985) C-acetyltransferase activity(GO:0016453)
0.1 1.2 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.1 3.5 GO:0031489 myosin V binding(GO:0031489)
0.1 0.6 GO:0070573 tripeptidyl-peptidase activity(GO:0008240) metallodipeptidase activity(GO:0070573)
0.1 2.9 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.1 0.4 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.1 0.8 GO:0015234 thiamine transmembrane transporter activity(GO:0015234)
0.1 1.7 GO:0048038 quinone binding(GO:0048038)
0.1 0.3 GO:0070052 collagen V binding(GO:0070052)
0.1 1.8 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 1.6 GO:0070566 adenylyltransferase activity(GO:0070566)
0.1 1.7 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)
0.1 0.8 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 0.3 GO:0019770 IgG receptor activity(GO:0019770)
0.1 0.9 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 0.3 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.1 GO:0051747 cytosine C-5 DNA demethylase activity(GO:0051747)
0.0 0.4 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.1 GO:0031871 proteinase activated receptor binding(GO:0031871)
0.0 0.4 GO:0043237 laminin-1 binding(GO:0043237)
0.0 0.7 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.7 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 1.1 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.9 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.3 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 0.1 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.0 1.2 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 0.6 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 0.1 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 1.4 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.6 GO:0003684 damaged DNA binding(GO:0003684)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 0.4 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway
0.0 1.5 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.7 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 1.2 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.7 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.9 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.5 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.7 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 1.2 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 0.7 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.1 2.3 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.9 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.8 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 0.2 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 0.9 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.7 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.9 REACTOME_PIP3_ACTIVATES_AKT_SIGNALING Genes involved in PIP3 activates AKT signaling
0.0 2.2 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.7 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.5 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions