Motif ID: Gli2

Z-value: 0.790


Transcription factors associated with Gli2:

Gene SymbolEntrez IDGene Name
Gli2 ENSMUSG00000048402.8 Gli2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gli2mm10_v2_chr1_-_119053619_1190536380.182.5e-01Click!


Activity profile for motif Gli2.

activity profile for motif Gli2


Sorted Z-values histogram for motif Gli2

Sorted Z-values for motif Gli2



Network of associatons between targets according to the STRING database.



First level regulatory network of Gli2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_23248264 7.659 ENSMUST00000031709.5
Fezf1
Fez family zinc finger 1
chr15_-_56694525 5.856 ENSMUST00000050544.7
Has2
hyaluronan synthase 2
chr6_-_72789240 5.834 ENSMUST00000069536.5
Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
chr6_-_72788952 5.327 ENSMUST00000114053.2
Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
chrX_-_141725181 5.294 ENSMUST00000067841.7
Irs4
insulin receptor substrate 4
chr7_-_137314394 3.730 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
Ebf3



early B cell factor 3



chr12_+_58211772 3.340 ENSMUST00000110671.2
ENSMUST00000044299.2
Sstr1

somatostatin receptor 1

chr7_-_4752972 3.321 ENSMUST00000183971.1
ENSMUST00000182173.1
ENSMUST00000182738.1
ENSMUST00000184143.1
ENSMUST00000182111.1
ENSMUST00000182048.1
ENSMUST00000063324.7
Cox6b2






cytochrome c oxidase subunit VIb polypeptide 2






chr12_+_38780284 2.898 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
Etv1


ets variant gene 1


chr9_-_43239816 2.860 ENSMUST00000034512.5
Oaf
OAF homolog (Drosophila)
chr8_+_127064022 2.403 ENSMUST00000160272.1
ENSMUST00000079777.5
ENSMUST00000162907.1
Pard3


par-3 (partitioning defective 3) homolog (C. elegans)


chr4_+_36952930 2.349 ENSMUST00000144029.1
Gm12371
predicted gene 12371
chrX_-_9662950 2.293 ENSMUST00000033519.2
Dynlt3
dynein light chain Tctex-type 3
chr5_-_24527276 2.221 ENSMUST00000088311.4
Gbx1
gastrulation brain homeobox 1
chr8_+_127064107 2.166 ENSMUST00000162536.1
ENSMUST00000026921.6
ENSMUST00000162665.1
ENSMUST00000160766.1
ENSMUST00000162602.1
ENSMUST00000162531.1
ENSMUST00000160581.1
ENSMUST00000161355.1
ENSMUST00000159537.1
Pard3








par-3 (partitioning defective 3) homolog (C. elegans)








chr8_+_127063893 2.047 ENSMUST00000162309.1
Pard3
par-3 (partitioning defective 3) homolog (C. elegans)
chr13_+_5861489 1.714 ENSMUST00000000080.6
Klf6
Kruppel-like factor 6
chr16_-_88056176 1.691 ENSMUST00000072256.5
ENSMUST00000023652.8
ENSMUST00000114137.1
Grik1


glutamate receptor, ionotropic, kainate 1


chr15_-_85581809 1.676 ENSMUST00000023015.7
Wnt7b
wingless-related MMTV integration site 7B
chr18_+_86394952 1.622 ENSMUST00000058829.2
Neto1
neuropilin (NRP) and tolloid (TLL)-like 1
chr7_-_116308241 1.592 ENSMUST00000183057.1
ENSMUST00000182487.1
ENSMUST00000181998.1
Plekha7


pleckstrin homology domain containing, family A member 7


chr4_+_63215402 1.560 ENSMUST00000036300.6
Col27a1
collagen, type XXVII, alpha 1
chr5_-_53213447 1.529 ENSMUST00000031090.6
Sel1l3
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr13_+_35741313 1.498 ENSMUST00000163595.2
Cdyl
chromodomain protein, Y chromosome-like
chr4_-_126256226 1.467 ENSMUST00000122129.1
ENSMUST00000061143.8
ENSMUST00000106132.2
Map7d1


MAP7 domain containing 1


chr6_+_120666388 1.462 ENSMUST00000112686.1
Cecr2
cat eye syndrome chromosome region, candidate 2
chr10_-_114801364 1.452 ENSMUST00000061632.7
Trhde
TRH-degrading enzyme
chr1_+_167001417 1.424 ENSMUST00000165874.1
Fam78b
family with sequence similarity 78, member B
chr4_-_135971894 1.278 ENSMUST00000105852.1
Lypla2
lysophospholipase 2
chr15_+_95790831 1.257 ENSMUST00000071874.6
Ano6
anoctamin 6
chr4_-_83486453 1.185 ENSMUST00000107214.2
ENSMUST00000107215.2
ENSMUST00000030207.8
Psip1


PC4 and SFRS1 interacting protein 1


chr3_-_135608221 1.172 ENSMUST00000132668.1
Nfkb1
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
chr19_+_6047081 1.162 ENSMUST00000025723.8
Syvn1
synovial apoptosis inhibitor 1, synoviolin
chr19_+_6975048 1.132 ENSMUST00000070850.6
Ppp1r14b
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr4_+_117096049 1.123 ENSMUST00000030443.5
Ptch2
patched homolog 2
chr1_+_71652837 1.120 ENSMUST00000097699.2
Apol7d
apolipoprotein L 7d
chr19_+_6047055 1.105 ENSMUST00000134667.1
Syvn1
synovial apoptosis inhibitor 1, synoviolin
chr7_-_144738520 1.047 ENSMUST00000118556.2
ENSMUST00000033393.8
Ano1

anoctamin 1, calcium activated chloride channel

chr18_-_35662180 1.039 ENSMUST00000025209.4
ENSMUST00000096573.2
Spata24

spermatogenesis associated 24

chr16_+_19760902 1.036 ENSMUST00000119468.1
B3gnt5
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
chr7_-_133123160 1.035 ENSMUST00000166439.1
Ctbp2
C-terminal binding protein 2
chr11_+_101176041 1.026 ENSMUST00000103109.3
Cntnap1
contactin associated protein-like 1
chr5_-_115300957 1.021 ENSMUST00000009157.3
Dynll1
dynein light chain LC8-type 1
chr5_-_115300912 1.001 ENSMUST00000112090.1
Dynll1
dynein light chain LC8-type 1
chr11_+_100619217 0.990 ENSMUST00000107376.1
Nkiras2
NFKB inhibitor interacting Ras-like protein 2
chr7_-_133123312 0.985 ENSMUST00000124096.1
ENSMUST00000171022.1
ENSMUST00000163601.1
ENSMUST00000165534.1
ENSMUST00000033269.8
Fgfr2
Ctbp2



fibroblast growth factor receptor 2
C-terminal binding protein 2



chr9_+_62342449 0.978 ENSMUST00000156461.1
Anp32a
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
chr4_-_83486178 0.975 ENSMUST00000130626.1
Psip1
PC4 and SFRS1 interacting protein 1
chr4_-_59783800 0.968 ENSMUST00000107526.1
ENSMUST00000095063.4
Inip

INTS3 and NABP interacting protein

chr16_-_17132377 0.947 ENSMUST00000023453.7
Sdf2l1
stromal cell-derived factor 2-like 1
chr4_+_32800246 0.938 ENSMUST00000062802.4
Lyrm2
LYR motif containing 2
chr3_+_36552600 0.915 ENSMUST00000029269.5
ENSMUST00000136890.1
Exosc9

exosome component 9

chr11_-_107794557 0.829 ENSMUST00000021066.3
Cacng4
calcium channel, voltage-dependent, gamma subunit 4
chr18_-_38250157 0.807 ENSMUST00000181871.1
1700086O06Rik
RIKEN cDNA 1700086O06 gene
chr6_+_67266979 0.795 ENSMUST00000042990.4
Serbp1
serpine1 mRNA binding protein 1
chr7_-_144738478 0.789 ENSMUST00000121758.1
Ano1
anoctamin 1, calcium activated chloride channel
chr14_+_64950037 0.760 ENSMUST00000043914.5
Ints9
integrator complex subunit 9
chr2_+_69861562 0.746 ENSMUST00000090852.4
ENSMUST00000166411.1
Ssb

Sjogren syndrome antigen B

chr17_-_31658729 0.738 ENSMUST00000166526.1
ENSMUST00000014684.4
U2af1

U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1

chr4_+_121039385 0.710 ENSMUST00000030372.5
Col9a2
collagen, type IX, alpha 2
chr7_-_133123409 0.708 ENSMUST00000170459.1
ENSMUST00000166400.1
Ctbp2

C-terminal binding protein 2

chr2_+_71211706 0.681 ENSMUST00000112142.1
ENSMUST00000112139.1
ENSMUST00000112140.1
ENSMUST00000112138.1
Dync1i2



dynein cytoplasmic 1 intermediate chain 2



chr1_-_51915968 0.678 ENSMUST00000046390.7
Myo1b
myosin IB
chr1_-_51915901 0.669 ENSMUST00000018561.7
ENSMUST00000114537.2
Myo1b

myosin IB

chr9_+_114978507 0.669 ENSMUST00000183104.1
Osbpl10
oxysterol binding protein-like 10
chr4_-_19708922 0.667 ENSMUST00000108246.2
Wwp1
WW domain containing E3 ubiquitin protein ligase 1
chr5_-_117319242 0.651 ENSMUST00000100834.1
Gm10399
predicted gene 10399
chr9_+_55149364 0.648 ENSMUST00000121677.1
Ube2q2
ubiquitin-conjugating enzyme E2Q (putative) 2
chr11_-_100620165 0.646 ENSMUST00000014339.8
Dnajc7
DnaJ (Hsp40) homolog, subfamily C, member 7
chr10_+_80151154 0.636 ENSMUST00000146516.1
ENSMUST00000144526.1
Midn

midnolin

chr3_+_28781305 0.634 ENSMUST00000060500.7
Eif5a2
eukaryotic translation initiation factor 5A2
chr7_-_133122615 0.615 ENSMUST00000167218.1
Ctbp2
C-terminal binding protein 2
chr2_+_69861638 0.608 ENSMUST00000112260.1
Ssb
Sjogren syndrome antigen B
chr3_+_127633134 0.608 ENSMUST00000029587.7
Neurog2
neurogenin 2
chr9_-_69760924 0.601 ENSMUST00000071281.4
Foxb1
forkhead box B1
chr13_+_44730726 0.569 ENSMUST00000173704.1
ENSMUST00000044608.7
ENSMUST00000173367.1
Jarid2


jumonji, AT rich interactive domain 2


chrX_+_100729917 0.566 ENSMUST00000019503.7
Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chr2_+_130576170 0.549 ENSMUST00000028764.5
Oxt
oxytocin
chr9_+_114401076 0.546 ENSMUST00000063042.9
ENSMUST00000111820.2
Glb1
Tmppe
galactosidase, beta 1
transmembrane protein with metallophosphoesterase domain
chrX_+_137049586 0.524 ENSMUST00000047852.7
Fam199x
family with sequence similarity 199, X-linked
chr10_-_99126321 0.520 ENSMUST00000060761.5
Phxr2
per-hexamer repeat gene 2
chr5_+_23850590 0.498 ENSMUST00000181574.1
2700038G22Rik
RIKEN cDNA 2700038G22 gene
chr11_+_117308135 0.483 ENSMUST00000153668.1
Sept9
septin 9
chr2_+_164486455 0.480 ENSMUST00000069385.8
ENSMUST00000143690.1
Dbndd2

dysbindin (dystrobrevin binding protein 1) domain containing 2

chr2_-_157566319 0.479 ENSMUST00000109528.2
ENSMUST00000088494.2
Blcap

bladder cancer associated protein homolog (human)

chr11_+_51619731 0.470 ENSMUST00000127405.1
Nhp2
NHP2 ribonucleoprotein
chr2_-_37703275 0.460 ENSMUST00000072186.5
Strbp
spermatid perinuclear RNA binding protein
chr10_-_93589621 0.407 ENSMUST00000020203.6
Snrpf
small nuclear ribonucleoprotein polypeptide F
chr11_-_42000284 0.404 ENSMUST00000109292.2
ENSMUST00000109290.1
Gabrg2

gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2

chr8_-_67515606 0.393 ENSMUST00000032981.5
Gm9755
predicted pseudogene 9755
chr13_+_55445301 0.370 ENSMUST00000001115.8
ENSMUST00000099482.3
Grk6

G protein-coupled receptor kinase 6

chr3_+_9250602 0.355 ENSMUST00000155203.1
Zbtb10
zinc finger and BTB domain containing 10
chr14_-_70443442 0.322 ENSMUST00000000793.5
Polr3d
polymerase (RNA) III (DNA directed) polypeptide D
chr10_+_93589413 0.307 ENSMUST00000181835.1
4933408J17Rik
RIKEN cDNA 4933408J17 gene
chr7_+_81571246 0.297 ENSMUST00000165460.1
Whamm
WAS protein homolog associated with actin, golgi membranes and microtubules
chrX_+_100730178 0.285 ENSMUST00000113744.1
Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chr3_+_107036156 0.279 ENSMUST00000052718.3
Kcna3
potassium voltage-gated channel, shaker-related subfamily, member 3
chr7_-_121035096 0.259 ENSMUST00000065740.2
Gm9905
predicted gene 9905
chr19_+_6057888 0.259 ENSMUST00000043074.5
ENSMUST00000178310.1
Fau

Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived)

chr4_+_124700700 0.226 ENSMUST00000106199.3
ENSMUST00000038684.5
Fhl3

four and a half LIM domains 3

chr5_+_117319292 0.226 ENSMUST00000086464.4
Vsig10
V-set and immunoglobulin domain containing 10
chr2_-_120609319 0.219 ENSMUST00000102497.3
Lrrc57
leucine rich repeat containing 57
chr1_+_167349976 0.219 ENSMUST00000028004.9
Aldh9a1
aldehyde dehydrogenase 9, subfamily A1
chr1_+_55406163 0.218 ENSMUST00000042986.8
Plcl1
phospholipase C-like 1
chrX_+_20617503 0.215 ENSMUST00000115375.1
ENSMUST00000115374.1
ENSMUST00000084383.3
Rbm10


RNA binding motif protein 10


chr18_+_61555258 0.215 ENSMUST00000165123.1
Csnk1a1
casein kinase 1, alpha 1
chr1_-_175625580 0.210 ENSMUST00000027810.7
Fh1
fumarate hydratase 1
chrX_+_99003224 0.206 ENSMUST00000149999.1
Stard8
START domain containing 8
chr12_-_69357120 0.204 ENSMUST00000021368.8
Nemf
nuclear export mediator factor
chr11_-_100619576 0.197 ENSMUST00000155152.1
Dnajc7
DnaJ (Hsp40) homolog, subfamily C, member 7
chr11_-_42000532 0.192 ENSMUST00000070735.3
Gabrg2
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2
chr10_+_42502030 0.185 ENSMUST00000105500.1
ENSMUST00000019939.5
Snx3

sorting nexin 3

chr18_+_80206775 0.181 ENSMUST00000125127.1
ENSMUST00000025463.7
ENSMUST00000145963.1
ENSMUST00000025464.7
Gm16286

Txnl4a

predicted gene 16286

thioredoxin-like 4A

chr5_+_117319258 0.176 ENSMUST00000111967.1
Vsig10
V-set and immunoglobulin domain containing 10
chr2_-_120609283 0.160 ENSMUST00000102496.1
Lrrc57
leucine rich repeat containing 57
chrX_+_161717055 0.144 ENSMUST00000112338.1
Rai2
retinoic acid induced 2
chr2_+_121955964 0.142 ENSMUST00000036647.6
Ctdspl2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr4_+_103619580 0.142 ENSMUST00000106827.1
Dab1
disabled 1
chr16_-_20302358 0.136 ENSMUST00000048642.8
Parl
presenilin associated, rhomboid-like
chr2_-_120609500 0.132 ENSMUST00000133612.1
ENSMUST00000102498.1
ENSMUST00000102499.1
Lrrc57


leucine rich repeat containing 57


chr8_-_27174623 0.124 ENSMUST00000033878.6
ENSMUST00000054212.6
Rab11fip1

RAB11 family interacting protein 1 (class I)

chr4_+_155831630 0.124 ENSMUST00000105592.1
ENSMUST00000105591.1
Aurkaip1

aurora kinase A interacting protein 1

chr6_+_43265582 0.116 ENSMUST00000031750.7
Arhgef5
Rho guanine nucleotide exchange factor (GEF) 5
chr5_-_137786681 0.115 ENSMUST00000132726.1
Mepce
methylphosphate capping enzyme
chr5_-_137786651 0.104 ENSMUST00000031740.9
Mepce
methylphosphate capping enzyme
chr17_+_24669730 0.097 ENSMUST00000047179.5
Zfp598
zinc finger protein 598
chr3_-_95357156 0.084 ENSMUST00000107171.3
ENSMUST00000015841.5
ENSMUST00000107170.2
Setdb1


SET domain, bifurcated 1


chr4_+_33310306 0.078 ENSMUST00000108153.2
ENSMUST00000029942.7
Rngtt

RNA guanylyltransferase and 5'-phosphatase

chrX_-_95956890 0.074 ENSMUST00000079987.6
ENSMUST00000113864.2
Las1l

LAS1-like (S. cerevisiae)

chr9_+_109095427 0.073 ENSMUST00000072093.6
Plxnb1
plexin B1
chr5_-_134456227 0.070 ENSMUST00000111244.1
Gtf2ird1
general transcription factor II I repeat domain-containing 1
chr4_-_46536096 0.064 ENSMUST00000102924.2
Trim14
tripartite motif-containing 14
chr9_+_13662460 0.050 ENSMUST00000177755.1
Maml2
mastermind like 2 (Drosophila)
chr18_+_61555689 0.035 ENSMUST00000167187.1
Csnk1a1
casein kinase 1, alpha 1
chr6_-_137649211 0.027 ENSMUST00000134630.1
ENSMUST00000058210.6
ENSMUST00000111878.1
Eps8


epidermal growth factor receptor pathway substrate 8


chr9_-_107770945 0.026 ENSMUST00000183248.1
ENSMUST00000182022.1
ENSMUST00000035199.6
ENSMUST00000182659.1
Rbm5



RNA binding motif protein 5



chr9_+_108795971 0.025 ENSMUST00000085018.4
Ip6k2
inositol hexaphosphate kinase 2
chr9_-_108578657 0.022 ENSMUST00000068700.5
Wdr6
WD repeat domain 6
chr11_+_95712673 0.015 ENSMUST00000107717.1
Zfp652
zinc finger protein 652
chr18_+_80206887 0.010 ENSMUST00000127234.1
Gm16286
predicted gene 16286

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.7 11.2 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
1.5 5.9 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
1.3 7.7 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.1 6.6 GO:0003383 apical constriction(GO:0003383)
0.6 1.7 GO:0016332 establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
0.6 2.2 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.5 1.6 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.4 1.3 GO:0061588 calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylserine scrambling(GO:0061589) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591) phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.4 1.8 GO:0015705 iodide transport(GO:0015705)
0.3 1.4 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.3 3.3 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.3 0.9 GO:0034473 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476)
0.3 0.6 GO:0007412 axon target recognition(GO:0007412)
0.3 1.2 GO:1900127 positive regulation of hyaluronan biosynthetic process(GO:1900127)
0.3 1.7 GO:0032229 negative regulation of synaptic transmission, GABAergic(GO:0032229)
0.3 1.1 GO:0009957 epidermal cell fate specification(GO:0009957)
0.3 2.2 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.3 1.6 GO:0045218 zonula adherens maintenance(GO:0045218)
0.3 2.9 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.3 1.6 GO:0003431 growth plate cartilage chondrocyte development(GO:0003431)
0.3 1.0 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.2 2.7 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.2 1.3 GO:0098734 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.2 0.5 GO:0042713 sperm ejaculation(GO:0042713) negative regulation of gastric acid secretion(GO:0060455)
0.2 1.5 GO:0001842 neural fold formation(GO:0001842)
0.2 3.3 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.1 0.4 GO:0010360 negative regulation of anion channel activity(GO:0010360)
0.1 1.1 GO:0090527 actin filament reorganization(GO:0090527)
0.1 0.6 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.1 0.6 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.1 0.7 GO:0040031 snRNA modification(GO:0040031)
0.1 2.3 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236)
0.1 0.8 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.1 0.2 GO:0006106 fumarate metabolic process(GO:0006106)
0.1 0.5 GO:0019388 galactose catabolic process(GO:0019388)
0.1 0.6 GO:0071420 cellular response to histamine(GO:0071420)
0.1 0.9 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.1 0.2 GO:2000642 negative regulation of early endosome to late endosome transport(GO:2000642)
0.0 0.1 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.0 1.5 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.6 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.0 0.2 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.0 0.1 GO:0002408 myeloid dendritic cell chemotaxis(GO:0002408)
0.0 0.2 GO:0018002 N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
0.0 0.8 GO:0016180 snRNA processing(GO:0016180)
0.0 0.1 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
0.0 0.2 GO:0034393 positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.0 4.0 GO:0008286 insulin receptor signaling pathway(GO:0008286)
0.0 0.1 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.0 0.2 GO:0042136 neurotransmitter biosynthetic process(GO:0042136)
0.0 0.3 GO:0002227 innate immune response in mucosa(GO:0002227)
0.0 0.1 GO:0090309 positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.0 0.5 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0 0.5 GO:0007638 mechanosensory behavior(GO:0007638)
0.0 0.1 GO:1900220 semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220)
0.0 0.5 GO:0030262 apoptotic nuclear changes(GO:0030262)
0.0 0.5 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0 0.1 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.0 1.3 GO:0006892 post-Golgi vesicle-mediated transport(GO:0006892)
0.0 1.0 GO:0030148 sphingolipid biosynthetic process(GO:0030148)
0.0 0.4 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.0 0.2 GO:1904424 regulation of GTP binding(GO:1904424)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 6.6 GO:0033269 internode region of axon(GO:0033269)
0.5 2.3 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.4 1.5 GO:0090537 CERF complex(GO:0090537)
0.3 1.7 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.2 3.3 GO:0030061 mitochondrial crista(GO:0030061)
0.2 1.0 GO:0070876 SOSS complex(GO:0070876)
0.2 0.7 GO:0005594 collagen type IX trimer(GO:0005594)
0.2 3.3 GO:0097470 ribbon synapse(GO:0097470)
0.2 1.2 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.1 1.6 GO:0005915 zonula adherens(GO:0005915)
0.1 5.0 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 0.9 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.1 1.6 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 0.5 GO:0090661 box H/ACA telomerase RNP complex(GO:0090661)
0.1 2.2 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 0.7 GO:0089701 U2AF(GO:0089701)
0.1 0.4 GO:0034715 U7 snRNP(GO:0005683) pICln-Sm protein complex(GO:0034715)
0.1 0.9 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 1.6 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.1 0.8 GO:0032039 integrator complex(GO:0032039)
0.0 0.3 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 1.3 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 1.0 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.5 GO:0031105 septin complex(GO:0031105)
0.0 0.8 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.6 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.2 GO:0031415 NatA complex(GO:0031415)
0.0 10.7 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.2 GO:0032009 early phagosome(GO:0032009)
0.0 0.7 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.3 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.2 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.0 0.2 GO:0030877 beta-catenin destruction complex(GO:0030877) keratin filament(GO:0045095)
0.0 0.5 GO:0043195 terminal bouton(GO:0043195)
0.0 1.7 GO:0001650 fibrillar center(GO:0001650)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.7 GO:0050501 hyaluronan synthase activity(GO:0050501)
1.1 3.3 GO:0004994 somatostatin receptor activity(GO:0004994)
0.5 2.2 GO:0097100 supercoiled DNA binding(GO:0097100)
0.5 1.8 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
0.4 1.7 GO:1902379 chemoattractant activity involved in axon guidance(GO:1902379)
0.4 3.3 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.4 1.1 GO:0005119 smoothened binding(GO:0005119) hedgehog receptor activity(GO:0008158)
0.3 1.0 GO:0047256 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
0.3 1.7 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.2 1.3 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.2 8.0 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.2 0.9 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.2 2.0 GO:0030235 nitric-oxide synthase regulator activity(GO:0030235)
0.1 2.3 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.1 1.6 GO:0070097 delta-catenin binding(GO:0070097)
0.1 1.3 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 0.5 GO:0004565 beta-galactosidase activity(GO:0004565)
0.1 0.9 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.1 5.4 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.1 11.2 GO:0008013 beta-catenin binding(GO:0008013)
0.1 1.4 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.1 0.4 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.1 0.7 GO:0050733 RS domain binding(GO:0050733)
0.1 0.5 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.1 1.5 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.2 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.0 0.7 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.2 GO:1990190 peptide-glutamate-N-acetyltransferase activity(GO:1990190)
0.0 1.2 GO:0042805 actinin binding(GO:0042805)
0.0 0.3 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 1.6 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.0 0.5 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.6 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.1 GO:0008192 RNA guanylyltransferase activity(GO:0008192)
0.0 0.6 GO:0070888 E-box binding(GO:0070888)
0.0 1.4 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 0.8 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.9 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 7.9 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 0.7 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.3 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 0.2 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 1.7 GO:0003774 motor activity(GO:0003774)
0.0 2.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.2 GO:0050811 GABA receptor binding(GO:0050811)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 8.4 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 11.9 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.1 2.1 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 2.9 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.1 1.7 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 2.3 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.1 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 3.5 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.6 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.1 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 1.0 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.7 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.3 6.6 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.3 2.2 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1 1.7 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 0.9 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.1 1.0 REACTOME_FGFR2C_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.1 2.0 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.1 0.5 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.1 1.7 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 3.5 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 2.3 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 2.3 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.4 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 2.8 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.2 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 1.0 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.6 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0 0.8 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 0.7 REACTOME_CLEAVAGE_OF_GROWING_TRANSCRIPT_IN_THE_TERMINATION_REGION_ Genes involved in Cleavage of Growing Transcript in the Termination Region
0.0 0.5 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres