Motif ID: Nkx2-3
Z-value: 0.900

Transcription factors associated with Nkx2-3:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Nkx2-3 | ENSMUSG00000044220.12 | Nkx2-3 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Nkx2-3 | mm10_v2_chr19_+_43612299_43612325 | 0.53 | 3.6e-04 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
3.7 | 40.9 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
2.0 | 5.9 | GO:0060166 | olfactory pit development(GO:0060166) |
1.9 | 5.6 | GO:0021759 | globus pallidus development(GO:0021759) |
1.4 | 5.4 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) |
1.2 | 3.5 | GO:0007521 | muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111) |
1.1 | 6.5 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
0.7 | 2.1 | GO:0061357 | Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) positive regulation of Wnt protein secretion(GO:0061357) |
0.7 | 5.4 | GO:0007406 | negative regulation of neuroblast proliferation(GO:0007406) |
0.6 | 3.1 | GO:0006538 | glutamate catabolic process(GO:0006538) |
0.6 | 1.8 | GO:0016095 | polyprenol catabolic process(GO:0016095) terpenoid catabolic process(GO:0016115) primary alcohol catabolic process(GO:0034310) |
0.5 | 3.2 | GO:0002317 | plasma cell differentiation(GO:0002317) |
0.5 | 2.5 | GO:1903215 | negative regulation of protein targeting to mitochondrion(GO:1903215) |
0.5 | 2.0 | GO:1904936 | cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936) |
0.5 | 3.4 | GO:0030916 | otic vesicle formation(GO:0030916) |
0.5 | 5.9 | GO:2001269 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269) |
0.4 | 1.7 | GO:0003347 | epicardial cell to mesenchymal cell transition(GO:0003347) |
0.3 | 1.3 | GO:0046552 | eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552) |
0.3 | 0.6 | GO:0021529 | spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) |
0.3 | 0.9 | GO:0038044 | negative regulation of receptor biosynthetic process(GO:0010871) transforming growth factor-beta secretion(GO:0038044) |
0.3 | 3.0 | GO:0061470 | interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619) |
0.3 | 1.5 | GO:0002121 | inter-male aggressive behavior(GO:0002121) |
0.3 | 0.8 | GO:0097274 | urea homeostasis(GO:0097274) |
0.3 | 0.8 | GO:0060023 | soft palate development(GO:0060023) |
0.3 | 2.8 | GO:0060539 | diaphragm development(GO:0060539) |
0.2 | 0.7 | GO:0042663 | regulation of endodermal cell fate specification(GO:0042663) |
0.2 | 1.1 | GO:0006564 | L-serine biosynthetic process(GO:0006564) |
0.2 | 1.9 | GO:0060501 | positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) |
0.2 | 1.2 | GO:0098535 | positive regulation of centriole replication(GO:0046601) de novo centriole assembly(GO:0098535) |
0.2 | 1.8 | GO:0018230 | peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231) |
0.1 | 1.5 | GO:0051798 | positive regulation of hair follicle development(GO:0051798) |
0.1 | 2.9 | GO:0021516 | dorsal spinal cord development(GO:0021516) |
0.1 | 0.6 | GO:0010510 | regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) |
0.1 | 0.8 | GO:0045218 | zonula adherens maintenance(GO:0045218) |
0.1 | 0.6 | GO:0015692 | vanadium ion transport(GO:0015676) lead ion transport(GO:0015692) |
0.1 | 0.3 | GO:1905000 | regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000) |
0.1 | 0.5 | GO:0014005 | microglia differentiation(GO:0014004) microglia development(GO:0014005) |
0.1 | 5.7 | GO:0048384 | retinoic acid receptor signaling pathway(GO:0048384) |
0.1 | 0.6 | GO:1903378 | positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378) |
0.1 | 0.4 | GO:0002101 | tRNA wobble cytosine modification(GO:0002101) oxidative single-stranded DNA demethylation(GO:0035552) |
0.1 | 1.0 | GO:0015721 | bile acid and bile salt transport(GO:0015721) |
0.1 | 0.8 | GO:0036371 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
0.1 | 1.7 | GO:0071392 | cellular response to estradiol stimulus(GO:0071392) |
0.1 | 0.6 | GO:1903847 | regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849) |
0.1 | 1.0 | GO:1903504 | regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504) |
0.1 | 0.7 | GO:0021780 | oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780) |
0.1 | 0.6 | GO:0097264 | self proteolysis(GO:0097264) |
0.1 | 1.8 | GO:0030903 | notochord development(GO:0030903) |
0.1 | 0.1 | GO:0060018 | astrocyte fate commitment(GO:0060018) |
0.1 | 0.5 | GO:0007296 | vitellogenesis(GO:0007296) |
0.1 | 2.1 | GO:0060236 | regulation of mitotic spindle organization(GO:0060236) |
0.1 | 0.6 | GO:0019388 | galactose catabolic process(GO:0019388) |
0.1 | 0.3 | GO:0051987 | positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987) |
0.1 | 0.5 | GO:0018344 | protein geranylgeranylation(GO:0018344) |
0.1 | 0.5 | GO:0034214 | protein hexamerization(GO:0034214) |
0.1 | 0.1 | GO:1901420 | negative regulation of response to alcohol(GO:1901420) |
0.1 | 0.4 | GO:0003383 | apical constriction(GO:0003383) |
0.1 | 0.5 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
0.1 | 1.3 | GO:0032291 | central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291) |
0.1 | 0.2 | GO:0071351 | interleukin-18-mediated signaling pathway(GO:0035655) cellular response to interleukin-18(GO:0071351) |
0.1 | 1.1 | GO:0010172 | embryonic body morphogenesis(GO:0010172) |
0.1 | 1.1 | GO:0040037 | negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037) |
0.1 | 2.8 | GO:0032611 | interleukin-1 beta production(GO:0032611) |
0.1 | 0.4 | GO:1903377 | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377) |
0.1 | 1.7 | GO:0043407 | negative regulation of MAP kinase activity(GO:0043407) |
0.1 | 2.3 | GO:0007026 | negative regulation of microtubule depolymerization(GO:0007026) |
0.1 | 0.2 | GO:0006012 | galactose metabolic process(GO:0006012) |
0.0 | 1.9 | GO:0016572 | histone phosphorylation(GO:0016572) |
0.0 | 0.1 | GO:0016554 | cytidine to uridine editing(GO:0016554) |
0.0 | 0.2 | GO:0060316 | positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316) |
0.0 | 0.2 | GO:0002326 | B cell lineage commitment(GO:0002326) |
0.0 | 0.2 | GO:0019323 | pentose catabolic process(GO:0019323) |
0.0 | 0.1 | GO:0023016 | signal transduction by trans-phosphorylation(GO:0023016) |
0.0 | 2.0 | GO:0021884 | forebrain neuron development(GO:0021884) |
0.0 | 0.4 | GO:0060837 | blood vessel endothelial cell differentiation(GO:0060837) |
0.0 | 0.1 | GO:0002188 | translation reinitiation(GO:0002188) |
0.0 | 2.1 | GO:0045600 | positive regulation of fat cell differentiation(GO:0045600) |
0.0 | 0.6 | GO:2000251 | positive regulation of actin cytoskeleton reorganization(GO:2000251) |
0.0 | 4.2 | GO:0030326 | embryonic limb morphogenesis(GO:0030326) embryonic appendage morphogenesis(GO:0035113) |
0.0 | 0.1 | GO:0034285 | response to sucrose(GO:0009744) response to disaccharide(GO:0034285) |
0.0 | 1.2 | GO:0007588 | excretion(GO:0007588) |
0.0 | 0.3 | GO:0045899 | positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899) |
0.0 | 0.1 | GO:1902915 | negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915) |
0.0 | 0.1 | GO:2000270 | negative regulation of fibroblast apoptotic process(GO:2000270) |
0.0 | 0.2 | GO:0000395 | mRNA 5'-splice site recognition(GO:0000395) |
0.0 | 0.3 | GO:0009404 | toxin metabolic process(GO:0009404) |
0.0 | 0.3 | GO:0048875 | chemical homeostasis within a tissue(GO:0048875) |
0.0 | 3.2 | GO:0018107 | peptidyl-threonine phosphorylation(GO:0018107) |
0.0 | 1.0 | GO:0002066 | columnar/cuboidal epithelial cell development(GO:0002066) |
0.0 | 1.2 | GO:0033138 | positive regulation of peptidyl-serine phosphorylation(GO:0033138) |
0.0 | 0.2 | GO:0002053 | positive regulation of mesenchymal cell proliferation(GO:0002053) |
0.0 | 0.1 | GO:0070171 | negative regulation of odontogenesis(GO:0042483) negative regulation of tooth mineralization(GO:0070171) |
0.0 | 0.2 | GO:0031507 | heterochromatin assembly(GO:0031507) |
0.0 | 0.2 | GO:0014823 | response to activity(GO:0014823) |
0.0 | 0.1 | GO:0090527 | actin filament reorganization(GO:0090527) |
0.0 | 0.0 | GO:1903347 | negative regulation of bicellular tight junction assembly(GO:1903347) |
0.0 | 1.8 | GO:0000086 | G2/M transition of mitotic cell cycle(GO:0000086) |
0.0 | 0.4 | GO:0010842 | retina layer formation(GO:0010842) |
0.0 | 0.4 | GO:0071353 | cellular response to interleukin-4(GO:0071353) |
0.0 | 0.4 | GO:0030851 | granulocyte differentiation(GO:0030851) |
0.0 | 0.1 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
0.0 | 0.2 | GO:0045974 | miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974) |
0.0 | 0.1 | GO:0006488 | dolichol-linked oligosaccharide biosynthetic process(GO:0006488) |
0.0 | 1.0 | GO:0006487 | protein N-linked glycosylation(GO:0006487) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.7 | 4.1 | GO:0001674 | female germ cell nucleus(GO:0001674) |
0.4 | 2.5 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
0.4 | 2.0 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
0.3 | 0.9 | GO:0034684 | integrin alphav-beta5 complex(GO:0034684) |
0.3 | 1.9 | GO:0001940 | male pronucleus(GO:0001940) |
0.3 | 2.0 | GO:0005818 | aster(GO:0005818) |
0.3 | 2.3 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
0.2 | 1.5 | GO:0000444 | MIS12/MIND type complex(GO:0000444) |
0.2 | 1.2 | GO:0098536 | deuterosome(GO:0098536) |
0.2 | 1.8 | GO:0002178 | palmitoyltransferase complex(GO:0002178) |
0.1 | 0.6 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
0.1 | 0.6 | GO:0070826 | paraferritin complex(GO:0070826) |
0.1 | 0.5 | GO:0060187 | cell pole(GO:0060187) |
0.1 | 5.2 | GO:0043034 | costamere(GO:0043034) |
0.1 | 1.2 | GO:0005916 | fascia adherens(GO:0005916) |
0.1 | 0.5 | GO:0005968 | Rab-protein geranylgeranyltransferase complex(GO:0005968) |
0.1 | 0.4 | GO:0070876 | SOSS complex(GO:0070876) |
0.1 | 0.9 | GO:0005677 | chromatin silencing complex(GO:0005677) |
0.1 | 0.6 | GO:0046581 | intercellular canaliculus(GO:0046581) |
0.1 | 0.3 | GO:0031523 | Myb complex(GO:0031523) |
0.1 | 0.6 | GO:0071439 | clathrin complex(GO:0071439) |
0.1 | 2.4 | GO:0060077 | inhibitory synapse(GO:0060077) |
0.1 | 2.1 | GO:0032590 | dendrite membrane(GO:0032590) |
0.1 | 0.6 | GO:0005915 | zonula adherens(GO:0005915) |
0.0 | 0.4 | GO:0033269 | internode region of axon(GO:0033269) |
0.0 | 0.4 | GO:0042382 | paraspeckles(GO:0042382) |
0.0 | 0.3 | GO:0034388 | Pwp2p-containing subcomplex of 90S preribosome(GO:0034388) |
0.0 | 0.8 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
0.0 | 1.0 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
0.0 | 0.5 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
0.0 | 0.3 | GO:1990023 | mitotic spindle midzone(GO:1990023) |
0.0 | 0.3 | GO:0031595 | nuclear proteasome complex(GO:0031595) |
0.0 | 0.1 | GO:0097233 | lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233) |
0.0 | 1.7 | GO:0043198 | dendritic shaft(GO:0043198) |
0.0 | 0.2 | GO:0000243 | commitment complex(GO:0000243) |
0.0 | 0.3 | GO:0033655 | host cell cytoplasm(GO:0030430) host cell cytoplasm part(GO:0033655) |
0.0 | 0.2 | GO:0035068 | micro-ribonucleoprotein complex(GO:0035068) |
0.0 | 2.0 | GO:0031225 | anchored component of membrane(GO:0031225) |
0.0 | 0.2 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
0.0 | 0.6 | GO:0005719 | nuclear euchromatin(GO:0005719) |
0.0 | 4.4 | GO:0016607 | nuclear speck(GO:0016607) |
0.0 | 0.1 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
0.0 | 0.2 | GO:0005640 | nuclear outer membrane(GO:0005640) |
0.0 | 1.8 | GO:0014069 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
0.0 | 0.8 | GO:0036064 | ciliary basal body(GO:0036064) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.1 | 5.4 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
0.9 | 11.0 | GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) |
0.6 | 1.7 | GO:0004994 | somatostatin receptor activity(GO:0004994) |
0.4 | 3.1 | GO:0004351 | glutamate decarboxylase activity(GO:0004351) |
0.4 | 1.8 | GO:0004032 | alditol:NADP+ 1-oxidoreductase activity(GO:0004032) |
0.3 | 1.2 | GO:0086075 | gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) gap junction channel activity involved in cell communication by electrical coupling(GO:1903763) |
0.3 | 9.4 | GO:0071837 | HMG box domain binding(GO:0071837) |
0.3 | 2.0 | GO:0015016 | [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016) |
0.3 | 2.3 | GO:0005519 | cytoskeletal regulatory protein binding(GO:0005519) |
0.3 | 5.6 | GO:0003708 | retinoic acid receptor activity(GO:0003708) |
0.2 | 2.5 | GO:0031852 | mu-type opioid receptor binding(GO:0031852) |
0.2 | 1.1 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
0.2 | 2.0 | GO:0061676 | importin-alpha family protein binding(GO:0061676) |
0.2 | 0.9 | GO:0019960 | C-X3-C chemokine binding(GO:0019960) neuregulin binding(GO:0038132) |
0.2 | 2.4 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
0.2 | 3.4 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
0.1 | 0.6 | GO:0008559 | xenobiotic-transporting ATPase activity(GO:0008559) |
0.1 | 0.6 | GO:0004740 | pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740) |
0.1 | 1.8 | GO:0015197 | peptide transporter activity(GO:0015197) |
0.1 | 1.4 | GO:0048185 | activin binding(GO:0048185) |
0.1 | 0.1 | GO:0008330 | protein tyrosine/threonine phosphatase activity(GO:0008330) |
0.1 | 0.6 | GO:0015086 | cadmium ion transmembrane transporter activity(GO:0015086) lead ion transmembrane transporter activity(GO:0015094) vanadium ion transmembrane transporter activity(GO:0015100) ferrous iron uptake transmembrane transporter activity(GO:0015639) |
0.1 | 1.5 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
0.1 | 0.6 | GO:0050816 | phosphothreonine binding(GO:0050816) |
0.1 | 33.9 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
0.1 | 0.4 | GO:0008508 | bile acid:sodium symporter activity(GO:0008508) |
0.1 | 0.2 | GO:0070915 | lysophosphatidic acid receptor activity(GO:0070915) |
0.1 | 0.6 | GO:0004614 | phosphoglucomutase activity(GO:0004614) |
0.1 | 1.6 | GO:0008483 | transaminase activity(GO:0008483) |
0.1 | 3.8 | GO:0097472 | cyclin-dependent protein kinase activity(GO:0097472) |
0.1 | 0.4 | GO:0043734 | DNA-N1-methyladenine dioxygenase activity(GO:0043734) |
0.1 | 0.5 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
0.1 | 0.2 | GO:0004335 | galactokinase activity(GO:0004335) |
0.1 | 0.8 | GO:0070097 | delta-catenin binding(GO:0070097) |
0.1 | 0.4 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
0.1 | 1.8 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
0.1 | 2.6 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
0.1 | 2.3 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
0.1 | 12.3 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
0.1 | 0.3 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
0.1 | 4.5 | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981) |
0.1 | 0.4 | GO:0038036 | sphingosine-1-phosphate receptor activity(GO:0038036) |
0.0 | 0.8 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
0.0 | 0.3 | GO:0036402 | proteasome-activating ATPase activity(GO:0036402) |
0.0 | 1.7 | GO:0005504 | fatty acid binding(GO:0005504) |
0.0 | 0.6 | GO:0001159 | core promoter proximal region DNA binding(GO:0001159) |
0.0 | 0.1 | GO:0004126 | cytidine deaminase activity(GO:0004126) |
0.0 | 4.1 | GO:0030165 | PDZ domain binding(GO:0030165) |
0.0 | 0.3 | GO:0031802 | type 5 metabotropic glutamate receptor binding(GO:0031802) |
0.0 | 0.5 | GO:0005092 | GDP-dissociation inhibitor activity(GO:0005092) |
0.0 | 5.2 | GO:0051015 | actin filament binding(GO:0051015) |
0.0 | 0.2 | GO:1990446 | U1 snRNP binding(GO:1990446) |
0.0 | 0.5 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
0.0 | 0.3 | GO:0005537 | mannose binding(GO:0005537) |
0.0 | 0.1 | GO:0019869 | chloride channel inhibitor activity(GO:0019869) |
0.0 | 1.1 | GO:0017022 | myosin binding(GO:0017022) |
0.0 | 0.1 | GO:0097642 | calcitonin family receptor activity(GO:0097642) |
0.0 | 0.0 | GO:0008384 | IkappaB kinase activity(GO:0008384) |
0.0 | 0.5 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
0.0 | 0.2 | GO:0043495 | protein anchor(GO:0043495) |
0.0 | 0.7 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
0.0 | 0.1 | GO:0051525 | NFAT protein binding(GO:0051525) |
0.0 | 0.5 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
0.0 | 0.6 | GO:0046875 | ephrin receptor binding(GO:0046875) |
0.0 | 0.6 | GO:0030507 | spectrin binding(GO:0030507) |
0.0 | 0.7 | GO:0031490 | chromatin DNA binding(GO:0031490) |
0.0 | 0.3 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
0.0 | 0.7 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
0.0 | 0.1 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
0.0 | 0.2 | GO:0016857 | racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857) |
0.0 | 1.5 | GO:0016779 | nucleotidyltransferase activity(GO:0016779) |
0.0 | 0.1 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
0.0 | 0.0 | GO:0015166 | polyol transmembrane transporter activity(GO:0015166) glycerol transmembrane transporter activity(GO:0015168) glycerol channel activity(GO:0015254) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.1 | 41.1 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
0.1 | 1.9 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
0.1 | 5.9 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
0.1 | 5.3 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
0.1 | 3.5 | PID_MAPK_TRK_PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
0.1 | 2.5 | SA_PTEN_PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
0.1 | 2.9 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
0.1 | 2.0 | PID_AURORA_A_PATHWAY | Aurora A signaling |
0.1 | 0.9 | PID_INTEGRIN_CS_PATHWAY | Integrin family cell surface interactions |
0.0 | 1.6 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
0.0 | 1.2 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
0.0 | 2.3 | PID_LKB1_PATHWAY | LKB1 signaling events |
0.0 | 1.2 | PID_NEPHRIN_NEPH1_PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
0.0 | 3.0 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
0.0 | 1.4 | PID_BMP_PATHWAY | BMP receptor signaling |
0.0 | 1.2 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
0.0 | 1.2 | PID_AURORA_B_PATHWAY | Aurora B signaling |
0.0 | 0.7 | ST_ERK1_ERK2_MAPK_PATHWAY | ERK1/ERK2 MAPK Pathway |
0.0 | 0.6 | PID_EPHRINB_REV_PATHWAY | Ephrin B reverse signaling |
0.0 | 0.4 | PID_PRL_SIGNALING_EVENTS_PATHWAY | Signaling events mediated by PRL |
0.0 | 0.4 | PID_S1P_S1P3_PATHWAY | S1P3 pathway |
0.0 | 3.4 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
0.0 | 1.3 | PID_P75_NTR_PATHWAY | p75(NTR)-mediated signaling |
0.0 | 0.4 | PID_P38_MKK3_6PATHWAY | p38 MAPK signaling pathway |
0.0 | 0.4 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
0.0 | 0.6 | PID_HIF2PATHWAY | HIF-2-alpha transcription factor network |
0.0 | 0.3 | PID_WNT_NONCANONICAL_PATHWAY | Noncanonical Wnt signaling pathway |
0.0 | 0.9 | PID_NOTCH_PATHWAY | Notch signaling pathway |
0.0 | 0.4 | SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES | Genes related to the insulin receptor pathway |
0.0 | 0.2 | PID_IL23_PATHWAY | IL23-mediated signaling events |
0.0 | 0.4 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
0.0 | 0.6 | PID_ECADHERIN_STABILIZATION_PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
0.0 | 0.3 | PID_TCPTP_PATHWAY | Signaling events mediated by TCPTP |
0.0 | 0.6 | PID_ERBB1_DOWNSTREAM_PATHWAY | ErbB1 downstream signaling |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 3.4 | REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION | Genes involved in FGFR1 ligand binding and activation |
0.2 | 6.0 | REACTOME_ERK_MAPK_TARGETS | Genes involved in ERK/MAPK targets |
0.1 | 3.1 | REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
0.1 | 1.9 | REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
0.1 | 1.2 | REACTOME_GAP_JUNCTION_DEGRADATION | Genes involved in Gap junction degradation |
0.1 | 1.6 | REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
0.1 | 1.1 | REACTOME_N_GLYCAN_ANTENNAE_ELONGATION | Genes involved in N-Glycan antennae elongation |
0.1 | 0.9 | REACTOME_PECAM1_INTERACTIONS | Genes involved in PECAM1 interactions |
0.1 | 2.0 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
0.0 | 0.6 | REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
0.0 | 2.4 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
0.0 | 0.6 | REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
0.0 | 0.4 | REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
0.0 | 0.9 | REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
0.0 | 1.7 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
0.0 | 0.3 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
0.0 | 0.2 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
0.0 | 1.9 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
0.0 | 0.4 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
0.0 | 1.3 | REACTOME_SIGNALING_BY_NOTCH1 | Genes involved in Signaling by NOTCH1 |
0.0 | 0.9 | REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
0.0 | 0.3 | REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
0.0 | 0.2 | REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
0.0 | 0.3 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |