Motif ID: Foxd3

Z-value: 0.644


Transcription factors associated with Foxd3:

Gene SymbolEntrez IDGene Name
Foxd3 ENSMUSG00000067261.3 Foxd3



Activity profile for motif Foxd3.

activity profile for motif Foxd3


Sorted Z-values histogram for motif Foxd3

Sorted Z-values for motif Foxd3



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxd3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_29090969 4.500 ENSMUST00000119901.1
Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr17_+_93199348 3.996 ENSMUST00000064775.6
Adcyap1
adenylate cyclase activating polypeptide 1
chr1_+_6734827 3.787 ENSMUST00000139838.1
St18
suppression of tumorigenicity 18
chr3_+_102010138 3.656 ENSMUST00000066187.4
Nhlh2
nescient helix loop helix 2
chr5_+_148265202 2.348 ENSMUST00000110515.2
Mtus2
microtubule associated tumor suppressor candidate 2
chr4_-_36056726 2.288 ENSMUST00000108124.3
Lingo2
leucine rich repeat and Ig domain containing 2
chr14_-_70630149 2.028 ENSMUST00000022694.9
Dmtn
dematin actin binding protein
chr5_+_148265307 2.014 ENSMUST00000110514.1
Mtus2
microtubule associated tumor suppressor candidate 2
chr5_+_148265265 2.013 ENSMUST00000071878.5
Mtus2
microtubule associated tumor suppressor candidate 2
chr6_-_3494587 1.937 ENSMUST00000049985.8
Hepacam2
HEPACAM family member 2
chr6_-_144209471 1.818 ENSMUST00000038815.7
Sox5
SRY-box containing gene 5
chr8_-_87959560 1.764 ENSMUST00000109655.2
Zfp423
zinc finger protein 423
chr6_-_144209558 1.739 ENSMUST00000111749.1
ENSMUST00000170367.2
Sox5

SRY-box containing gene 5

chr10_-_11080956 1.667 ENSMUST00000105560.1
Grm1
glutamate receptor, metabotropic 1
chr11_+_98798653 1.452 ENSMUST00000037930.6
Msl1
male-specific lethal 1 homolog (Drosophila)
chr2_+_181767040 1.443 ENSMUST00000108756.1
Myt1
myelin transcription factor 1
chr12_+_38783455 1.441 ENSMUST00000161980.1
ENSMUST00000160701.1
Etv1

ets variant gene 1

chr2_+_181767283 1.352 ENSMUST00000108757.2
Myt1
myelin transcription factor 1
chr5_-_88675190 1.234 ENSMUST00000133532.1
ENSMUST00000150438.1
Grsf1

G-rich RNA sequence binding factor 1

chr12_+_38783503 1.224 ENSMUST00000159334.1
Etv1
ets variant gene 1
chr14_-_93888732 1.172 ENSMUST00000068992.2
Pcdh9
protocadherin 9
chr16_+_13986596 1.142 ENSMUST00000056521.5
ENSMUST00000118412.1
ENSMUST00000131608.1
2900011O08Rik


RIKEN cDNA 2900011O08 gene


chr3_+_76075583 1.135 ENSMUST00000160261.1
Fstl5
follistatin-like 5
chr12_+_111971545 1.124 ENSMUST00000079009.5
Tdrd9
tudor domain containing 9
chr1_-_126830632 1.090 ENSMUST00000112583.1
ENSMUST00000094609.3
Nckap5

NCK-associated protein 5

chr17_+_28691419 1.058 ENSMUST00000124886.1
Mapk14
mitogen-activated protein kinase 14
chr15_+_100154379 1.032 ENSMUST00000023768.6
ENSMUST00000108971.2
Dip2b

DIP2 disco-interacting protein 2 homolog B (Drosophila)

chr1_-_126830786 1.005 ENSMUST00000162646.1
Nckap5
NCK-associated protein 5
chrX_-_163761323 0.985 ENSMUST00000059320.2
Rnf138rt1
ring finger protein 138, retrogene 1
chr2_+_152669461 0.815 ENSMUST00000125366.1
ENSMUST00000109825.1
ENSMUST00000089059.2
ENSMUST00000079247.3
H13



histocompatibility 13



chr2_-_120539852 0.813 ENSMUST00000171215.1
Zfp106
zinc finger protein 106
chr6_+_77242715 0.716 ENSMUST00000161677.1
Lrrtm1
leucine rich repeat transmembrane neuronal 1
chr6_+_77242644 0.694 ENSMUST00000159616.1
Lrrtm1
leucine rich repeat transmembrane neuronal 1
chr14_-_52213379 0.684 ENSMUST00000140603.1
Chd8
chromodomain helicase DNA binding protein 8
chr11_+_83302817 0.666 ENSMUST00000142680.1
Ap2b1
adaptor-related protein complex 2, beta 1 subunit
chr11_-_107189325 0.662 ENSMUST00000018577.7
ENSMUST00000106757.1
Nol11

nucleolar protein 11

chr10_-_19011948 0.651 ENSMUST00000105527.1
Tnfaip3
tumor necrosis factor, alpha-induced protein 3
chr2_+_9882622 0.589 ENSMUST00000114919.1
4930412O13Rik
RIKEN cDNA 4930412O13 gene
chr9_+_105642957 0.584 ENSMUST00000065778.6
Pik3r4
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 4, p150
chr4_-_82850721 0.500 ENSMUST00000139401.1
Zdhhc21
zinc finger, DHHC domain containing 21
chr6_+_38918969 0.491 ENSMUST00000003017.6
Tbxas1
thromboxane A synthase 1, platelet
chr9_+_54980880 0.485 ENSMUST00000093844.3
Chrna5
cholinergic receptor, nicotinic, alpha polypeptide 5
chr17_+_28691342 0.475 ENSMUST00000114758.1
ENSMUST00000004990.6
ENSMUST00000062694.8
ENSMUST00000114754.1
Mapk14



mitogen-activated protein kinase 14



chr2_+_125136692 0.451 ENSMUST00000099452.2
Ctxn2
cortexin 2
chr1_+_134415414 0.434 ENSMUST00000112237.1
Adipor1
adiponectin receptor 1
chr10_-_127030813 0.384 ENSMUST00000040560.4
Tsfm
Ts translation elongation factor, mitochondrial
chr2_+_14388434 0.337 ENSMUST00000133258.1
Slc39a12
solute carrier family 39 (zinc transporter), member 12
chr6_-_137571007 0.315 ENSMUST00000100841.2
Eps8
epidermal growth factor receptor pathway substrate 8
chr5_-_120612558 0.273 ENSMUST00000140554.1
ENSMUST00000031599.2
ENSMUST00000177800.1
1110008J03Rik


RIKEN cDNA 1110008J03 gene


chr4_+_115737754 0.270 ENSMUST00000106522.2
Efcab14
EF-hand calcium binding domain 14
chr10_-_127030789 0.235 ENSMUST00000120547.1
ENSMUST00000152054.1
Tsfm

Ts translation elongation factor, mitochondrial

chrX_+_164373363 0.231 ENSMUST00000033751.7
Figf
c-fos induced growth factor
chr4_+_115737738 0.230 ENSMUST00000106525.2
Efcab14
EF-hand calcium binding domain 14
chr10_+_11609256 0.100 ENSMUST00000052902.7
Gm9797
predicted pseudogene 9797
chr19_+_8953826 0.089 ENSMUST00000096239.5
Tut1
terminal uridylyl transferase 1, U6 snRNA-specific
chr9_+_36832684 0.085 ENSMUST00000034630.8
Fez1
fasciculation and elongation protein zeta 1 (zygin I)
chr10_-_88605017 0.080 ENSMUST00000119185.1
ENSMUST00000121629.1
Mybpc1

myosin binding protein C, slow-type

chr19_-_8713862 0.066 ENSMUST00000010239.4
Slc3a2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr1_-_170867761 0.047 ENSMUST00000027974.6
Atf6
activating transcription factor 6
chr16_-_16527364 0.045 ENSMUST00000069284.7
Fgd4
FYVE, RhoGEF and PH domain containing 4
chr9_+_96258697 0.016 ENSMUST00000179416.1
Tfdp2
transcription factor Dp 2
chr18_+_37725706 0.005 ENSMUST00000066149.6
Pcdhga9
protocadherin gamma subfamily A, 9

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 4.0 GO:0071649 negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865) regulation of chemokine (C-C motif) ligand 5 production(GO:0071649) positive regulation of somatostatin secretion(GO:0090274)
0.7 2.0 GO:0035585 calcium-mediated signaling using extracellular calcium source(GO:0035585)
0.5 4.5 GO:0071493 cellular response to UV-B(GO:0071493)
0.4 3.6 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.4 1.7 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.4 1.5 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835)
0.4 1.1 GO:1903976 negative regulation of glial cell migration(GO:1903976)
0.3 3.8 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.3 0.8 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.3 2.8 GO:0060539 diaphragm development(GO:0060539)
0.2 2.7 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.2 0.7 GO:0070428 granuloma formation(GO:0002432) negative regulation of toll-like receptor 3 signaling pathway(GO:0034140) toll-like receptor 5 signaling pathway(GO:0034146) regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428) regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070432)
0.2 1.1 GO:0034587 piRNA metabolic process(GO:0034587)
0.2 0.6 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.1 3.7 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.1 0.6 GO:0030242 pexophagy(GO:0030242)
0.1 0.7 GO:1901838 positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838)
0.1 0.5 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.1 0.3 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.1 0.7 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.1 0.7 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.1 1.5 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.1 0.5 GO:0035095 behavioral response to nicotine(GO:0035095)
0.1 1.4 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.0 0.5 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 1.8 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 0.4 GO:0033210 leptin-mediated signaling pathway(GO:0033210)
0.0 2.3 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.1 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.0 1.7 GO:0007098 centrosome cycle(GO:0007098)
0.0 0.1 GO:0015803 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.5 GO:0070557 PCNA-p21 complex(GO:0070557)
0.5 2.0 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.3 1.5 GO:0072487 MSL complex(GO:0072487)
0.2 0.6 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.2 0.8 GO:0071556 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.2 1.1 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.1 1.7 GO:0038037 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
0.1 6.4 GO:0045171 intercellular bridge(GO:0045171)
0.0 0.5 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 4.0 GO:0043195 terminal bouton(GO:0043195)
0.0 0.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 1.2 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.7 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 3.8 GO:0032993 protein-DNA complex(GO:0032993)
0.0 3.2 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 0.7 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 1.5 GO:0000922 spindle pole(GO:0000922)
0.0 0.1 GO:0005859 muscle myosin complex(GO:0005859)
0.0 1.9 GO:0030496 midbody(GO:0030496)
0.0 1.2 GO:0044291 cell-cell contact zone(GO:0044291)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.5 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.4 1.7 GO:0001639 PLC activating G-protein coupled glutamate receptor activity(GO:0001639) G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.3 1.5 GO:0051525 NFAT protein binding(GO:0051525)
0.2 4.0 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.1 0.8 GO:0001515 opioid peptide activity(GO:0001515)
0.1 0.4 GO:0097003 adipokinetic hormone receptor activity(GO:0097003)
0.1 0.8 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.1 3.7 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 0.5 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 2.7 GO:0043621 protein self-association(GO:0043621)
0.0 0.7 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.6 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 1.0 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 2.8 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 6.4 GO:0008017 microtubule binding(GO:0008017)
0.0 3.8 GO:0001047 core promoter binding(GO:0001047)
0.0 0.1 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 0.5 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.1 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.0 GO:0035497 cAMP response element binding(GO:0035497)
0.0 1.1 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.0 1.4 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 2.7 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.5 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 4.2 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.7 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 0.2 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.5 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.1 1.7 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 1.5 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.1 4.0 REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS Genes involved in Glucagon-type ligand receptors
0.1 0.5 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.6 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.5 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.7 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.7 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.2 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.5 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation