Motif ID: Pou2f2_Pou3f1
Z-value: 2.204


Transcription factors associated with Pou2f2_Pou3f1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Pou2f2 | ENSMUSG00000008496.12 | Pou2f2 |
Pou3f1 | ENSMUSG00000090125.2 | Pou3f1 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Pou3f1 | mm10_v2_chr4_+_124657646_124657656 | -0.82 | 4.3e-11 | Click! |
Pou2f2 | mm10_v2_chr7_-_25132473_25132512 | -0.58 | 7.8e-05 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
4.2 | 12.6 | GO:0061075 | cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871) |
3.6 | 14.4 | GO:0021648 | zygotic determination of anterior/posterior axis, embryo(GO:0007354) cranial nerve formation(GO:0021603) vestibulocochlear nerve morphogenesis(GO:0021648) |
3.6 | 14.3 | GO:0045608 | inhibition of neuroepithelial cell differentiation(GO:0002085) negative regulation of auditory receptor cell differentiation(GO:0045608) |
3.4 | 10.3 | GO:1904059 | regulation of locomotor rhythm(GO:1904059) |
3.4 | 20.5 | GO:1904936 | cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936) |
2.9 | 8.8 | GO:1904956 | dermatome development(GO:0061054) sclerotome development(GO:0061056) regulation of dermatome development(GO:0061183) regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041) |
2.8 | 11.0 | GO:0010890 | positive regulation of sequestering of triglyceride(GO:0010890) |
2.6 | 13.0 | GO:0021905 | pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) positive regulation of cell fate specification(GO:0042660) sensory neuron migration(GO:1904937) |
2.6 | 28.3 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
2.5 | 30.2 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
2.5 | 4.9 | GO:0021759 | globus pallidus development(GO:0021759) |
2.3 | 6.8 | GO:0060598 | dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598) |
1.9 | 7.8 | GO:0010986 | positive regulation of lipoprotein particle clearance(GO:0010986) |
1.8 | 7.2 | GO:0046552 | eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552) |
1.8 | 3.5 | GO:0021546 | rhombomere development(GO:0021546) |
1.7 | 13.4 | GO:0014807 | regulation of somitogenesis(GO:0014807) |
1.7 | 11.7 | GO:0035331 | negative regulation of hippo signaling(GO:0035331) |
1.4 | 4.1 | GO:1904170 | regulation of bleb assembly(GO:1904170) |
1.3 | 3.9 | GO:0009826 | unidimensional cell growth(GO:0009826) susceptibility to natural killer cell mediated cytotoxicity(GO:0042271) |
1.3 | 16.7 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
1.3 | 6.4 | GO:0060842 | arterial endothelial cell differentiation(GO:0060842) |
1.3 | 21.6 | GO:0035563 | positive regulation of chromatin binding(GO:0035563) |
1.2 | 4.7 | GO:0043973 | histone H3-K4 acetylation(GO:0043973) |
1.1 | 3.4 | GO:0016332 | establishment or maintenance of polarity of embryonic epithelium(GO:0016332) |
1.1 | 13.0 | GO:2001269 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269) |
1.0 | 4.0 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
1.0 | 6.8 | GO:0000320 | re-entry into mitotic cell cycle(GO:0000320) |
0.9 | 1.8 | GO:0051892 | negative regulation of cardioblast differentiation(GO:0051892) |
0.9 | 2.7 | GO:0048023 | positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378) |
0.9 | 2.7 | GO:0097491 | trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486) sympathetic neuron projection extension(GO:0097490) sympathetic neuron projection guidance(GO:0097491) |
0.8 | 2.5 | GO:0045014 | detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) detection of glucose(GO:0051594) |
0.8 | 5.6 | GO:0006003 | fructose 2,6-bisphosphate metabolic process(GO:0006003) |
0.8 | 4.6 | GO:0002326 | B cell lineage commitment(GO:0002326) |
0.7 | 6.0 | GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) |
0.7 | 2.8 | GO:1903998 | regulation of eating behavior(GO:1903998) |
0.7 | 5.6 | GO:0048664 | neuron fate determination(GO:0048664) |
0.7 | 4.9 | GO:0019532 | oxalate transport(GO:0019532) |
0.7 | 10.3 | GO:0021891 | olfactory bulb interneuron development(GO:0021891) |
0.7 | 5.5 | GO:0002072 | optic cup morphogenesis involved in camera-type eye development(GO:0002072) |
0.7 | 8.0 | GO:0021521 | ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573) |
0.6 | 2.5 | GO:0021502 | neural fold elevation formation(GO:0021502) |
0.6 | 1.8 | GO:0001978 | regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback(GO:0001978) |
0.6 | 4.6 | GO:0006477 | protein sulfation(GO:0006477) |
0.6 | 4.5 | GO:1902166 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166) |
0.5 | 9.2 | GO:0033234 | negative regulation of protein sumoylation(GO:0033234) |
0.5 | 4.2 | GO:1902746 | regulation of lens fiber cell differentiation(GO:1902746) |
0.5 | 57.2 | GO:0006342 | chromatin silencing(GO:0006342) |
0.5 | 2.0 | GO:0090324 | negative regulation of oxidative phosphorylation(GO:0090324) |
0.5 | 9.1 | GO:0090129 | positive regulation of synapse maturation(GO:0090129) |
0.5 | 7.0 | GO:0034501 | protein localization to kinetochore(GO:0034501) |
0.5 | 10.8 | GO:0001967 | suckling behavior(GO:0001967) |
0.5 | 1.5 | GO:0061744 | motor behavior(GO:0061744) |
0.5 | 1.9 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) regulation of prostatic bud formation(GO:0060685) negative regulation of prostatic bud formation(GO:0060686) |
0.5 | 1.8 | GO:1903715 | regulation of aerobic respiration(GO:1903715) |
0.4 | 1.3 | GO:2000054 | regulation of chondrocyte development(GO:0061181) regulation of centromeric sister chromatid cohesion(GO:0070602) negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054) |
0.4 | 6.7 | GO:0097237 | cellular response to toxic substance(GO:0097237) |
0.4 | 5.0 | GO:1902231 | positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231) |
0.4 | 3.5 | GO:0002082 | regulation of oxidative phosphorylation(GO:0002082) |
0.4 | 18.0 | GO:0006284 | base-excision repair(GO:0006284) |
0.4 | 1.1 | GO:1903644 | regulation of chaperone-mediated protein folding(GO:1903644) |
0.4 | 18.3 | GO:0060325 | face morphogenesis(GO:0060325) |
0.4 | 1.4 | GO:2000138 | positive regulation of cell proliferation involved in heart morphogenesis(GO:2000138) |
0.4 | 1.8 | GO:2000255 | negative regulation of male germ cell proliferation(GO:2000255) |
0.3 | 1.3 | GO:0072272 | proximal/distal pattern formation involved in metanephric nephron development(GO:0072272) |
0.3 | 12.0 | GO:0000038 | very long-chain fatty acid metabolic process(GO:0000038) |
0.3 | 1.9 | GO:2000210 | positive regulation of anoikis(GO:2000210) |
0.3 | 31.4 | GO:0006334 | nucleosome assembly(GO:0006334) |
0.3 | 0.8 | GO:2001013 | cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204) epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013) |
0.3 | 2.9 | GO:0060056 | mammary gland involution(GO:0060056) |
0.2 | 2.2 | GO:0051152 | positive regulation of smooth muscle cell differentiation(GO:0051152) |
0.2 | 1.7 | GO:0089711 | L-glutamate transmembrane transport(GO:0089711) |
0.2 | 4.1 | GO:0014049 | positive regulation of glutamate secretion(GO:0014049) |
0.2 | 0.8 | GO:0002322 | B cell proliferation involved in immune response(GO:0002322) |
0.2 | 0.6 | GO:0044026 | DNA hypermethylation(GO:0044026) hypermethylation of CpG island(GO:0044027) |
0.2 | 0.6 | GO:0031660 | regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662) positive regulation of calcium-transporting ATPase activity(GO:1901896) |
0.2 | 0.4 | GO:0000448 | cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000448) |
0.2 | 4.5 | GO:0010569 | regulation of double-strand break repair via homologous recombination(GO:0010569) |
0.2 | 1.3 | GO:0006265 | DNA topological change(GO:0006265) |
0.2 | 1.1 | GO:2000124 | regulation of endocannabinoid signaling pathway(GO:2000124) |
0.1 | 1.3 | GO:0090209 | negative regulation of triglyceride metabolic process(GO:0090209) |
0.1 | 3.1 | GO:0016180 | snRNA processing(GO:0016180) |
0.1 | 6.7 | GO:0032330 | regulation of chondrocyte differentiation(GO:0032330) |
0.1 | 0.4 | GO:1902202 | regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202) |
0.1 | 0.5 | GO:0060800 | regulation of cell differentiation involved in embryonic placenta development(GO:0060800) |
0.1 | 3.6 | GO:0021884 | forebrain neuron development(GO:0021884) |
0.1 | 5.3 | GO:0043029 | T cell homeostasis(GO:0043029) |
0.1 | 1.2 | GO:0061470 | interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619) |
0.1 | 0.7 | GO:0008343 | adult feeding behavior(GO:0008343) |
0.1 | 5.1 | GO:0032611 | interleukin-1 beta production(GO:0032611) |
0.1 | 0.4 | GO:0046898 | response to cycloheximide(GO:0046898) |
0.1 | 0.4 | GO:0046909 | intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445) |
0.1 | 4.8 | GO:0002066 | columnar/cuboidal epithelial cell development(GO:0002066) |
0.1 | 0.8 | GO:0032286 | central nervous system myelin maintenance(GO:0032286) |
0.1 | 6.2 | GO:0021510 | spinal cord development(GO:0021510) |
0.1 | 1.7 | GO:2000001 | regulation of DNA damage checkpoint(GO:2000001) |
0.1 | 2.3 | GO:0010842 | retina layer formation(GO:0010842) |
0.1 | 0.7 | GO:0060736 | prostate gland growth(GO:0060736) |
0.1 | 2.2 | GO:0030513 | positive regulation of BMP signaling pathway(GO:0030513) |
0.1 | 1.0 | GO:0016925 | protein sumoylation(GO:0016925) |
0.1 | 1.4 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
0.1 | 0.5 | GO:0030307 | positive regulation of cell growth(GO:0030307) |
0.1 | 4.5 | GO:1900046 | regulation of blood coagulation(GO:0030193) regulation of hemostasis(GO:1900046) |
0.1 | 3.0 | GO:0035307 | positive regulation of protein dephosphorylation(GO:0035307) |
0.1 | 0.7 | GO:0050858 | negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860) |
0.1 | 14.0 | GO:0019221 | cytokine-mediated signaling pathway(GO:0019221) |
0.1 | 1.4 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
0.0 | 1.5 | GO:0036075 | endochondral ossification(GO:0001958) replacement ossification(GO:0036075) |
0.0 | 0.9 | GO:0006471 | protein ADP-ribosylation(GO:0006471) |
0.0 | 7.6 | GO:0008360 | regulation of cell shape(GO:0008360) |
0.0 | 0.8 | GO:0043403 | skeletal muscle tissue regeneration(GO:0043403) |
0.0 | 4.3 | GO:0007098 | centrosome cycle(GO:0007098) |
0.0 | 1.0 | GO:2001222 | regulation of neuron migration(GO:2001222) |
0.0 | 1.0 | GO:0043171 | peptide catabolic process(GO:0043171) |
0.0 | 1.3 | GO:0045600 | positive regulation of fat cell differentiation(GO:0045600) |
0.0 | 1.0 | GO:0006261 | DNA-dependent DNA replication(GO:0006261) |
0.0 | 2.4 | GO:0010811 | positive regulation of cell-substrate adhesion(GO:0010811) |
0.0 | 0.2 | GO:0045199 | maintenance of epithelial cell apical/basal polarity(GO:0045199) |
0.0 | 1.7 | GO:0000086 | G2/M transition of mitotic cell cycle(GO:0000086) |
0.0 | 0.2 | GO:0007608 | sensory perception of smell(GO:0007608) |
0.0 | 1.3 | GO:0048469 | cell maturation(GO:0048469) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.6 | 18.0 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
2.3 | 9.2 | GO:0002111 | BRCA2-BRAF35 complex(GO:0002111) |
1.9 | 5.6 | GO:0043540 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540) |
1.6 | 11.0 | GO:0042627 | chylomicron(GO:0042627) |
1.4 | 11.5 | GO:0033269 | internode region of axon(GO:0033269) |
1.0 | 5.2 | GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex(GO:0002193) |
1.0 | 4.9 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
0.8 | 4.1 | GO:0005826 | actomyosin contractile ring(GO:0005826) |
0.7 | 52.3 | GO:0000786 | nucleosome(GO:0000786) |
0.7 | 4.3 | GO:0001674 | female germ cell nucleus(GO:0001674) |
0.5 | 2.7 | GO:0032585 | multivesicular body membrane(GO:0032585) |
0.5 | 7.0 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
0.3 | 6.0 | GO:0035102 | PRC1 complex(GO:0035102) |
0.3 | 1.3 | GO:0001651 | dense fibrillar component(GO:0001651) |
0.3 | 5.0 | GO:0043196 | varicosity(GO:0043196) |
0.3 | 1.7 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
0.2 | 1.0 | GO:0008623 | CHRAC(GO:0008623) |
0.2 | 3.1 | GO:0032039 | integrator complex(GO:0032039) |
0.2 | 0.6 | GO:0036128 | CatSper complex(GO:0036128) |
0.2 | 15.1 | GO:0032993 | protein-DNA complex(GO:0032993) |
0.1 | 15.9 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
0.1 | 52.5 | GO:0000790 | nuclear chromatin(GO:0000790) |
0.1 | 2.2 | GO:0005614 | interstitial matrix(GO:0005614) |
0.1 | 1.4 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
0.1 | 8.6 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
0.1 | 6.8 | GO:0042734 | presynaptic membrane(GO:0042734) |
0.1 | 5.4 | GO:0000794 | condensed nuclear chromosome(GO:0000794) |
0.1 | 3.6 | GO:0005882 | intermediate filament(GO:0005882) |
0.1 | 4.5 | GO:0016363 | nuclear matrix(GO:0016363) |
0.1 | 7.6 | GO:0043204 | perikaryon(GO:0043204) |
0.1 | 36.0 | GO:0005912 | adherens junction(GO:0005912) |
0.1 | 3.5 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
0.1 | 7.0 | GO:0030496 | midbody(GO:0030496) |
0.1 | 9.8 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
0.1 | 8.1 | GO:0043209 | myelin sheath(GO:0043209) |
0.0 | 48.3 | GO:0005615 | extracellular space(GO:0005615) |
0.0 | 1.4 | GO:0032420 | stereocilium(GO:0032420) |
0.0 | 0.4 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
0.0 | 1.7 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
0.0 | 10.4 | GO:0016607 | nuclear speck(GO:0016607) |
0.0 | 0.4 | GO:0042788 | polysomal ribosome(GO:0042788) |
0.0 | 1.1 | GO:0016234 | inclusion body(GO:0016234) |
0.0 | 0.9 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
0.0 | 0.2 | GO:0030673 | axolemma(GO:0030673) |
0.0 | 0.4 | GO:0045111 | intermediate filament cytoskeleton(GO:0045111) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.9 | 7.8 | GO:0008970 | phosphatidylcholine 1-acylhydrolase activity(GO:0008970) |
1.9 | 30.9 | GO:0003680 | AT DNA binding(GO:0003680) |
1.4 | 7.0 | GO:0043515 | kinetochore binding(GO:0043515) |
1.1 | 12.0 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
1.0 | 11.0 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
1.0 | 4.0 | GO:0015183 | L-aspartate transmembrane transporter activity(GO:0015183) |
1.0 | 6.9 | GO:0015016 | [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016) |
1.0 | 8.8 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
0.8 | 5.6 | GO:0070095 | fructose-6-phosphate binding(GO:0070095) |
0.8 | 4.6 | GO:0070644 | vitamin D response element binding(GO:0070644) |
0.8 | 4.6 | GO:0008467 | [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467) |
0.7 | 6.0 | GO:0031545 | peptidyl-proline 4-dioxygenase activity(GO:0031545) |
0.6 | 9.8 | GO:0030957 | Tat protein binding(GO:0030957) |
0.6 | 1.8 | GO:0003953 | NAD+ nucleosidase activity(GO:0003953) |
0.6 | 1.7 | GO:0000099 | sulfur amino acid transmembrane transporter activity(GO:0000099) |
0.5 | 4.7 | GO:0030274 | LIM domain binding(GO:0030274) |
0.4 | 4.9 | GO:0019531 | secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531) |
0.4 | 1.8 | GO:0004667 | prostaglandin-D synthase activity(GO:0004667) |
0.4 | 4.9 | GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) |
0.4 | 6.9 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
0.4 | 1.9 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
0.4 | 6.0 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
0.4 | 2.8 | GO:0070290 | N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290) |
0.3 | 1.3 | GO:0097100 | supercoiled DNA binding(GO:0097100) |
0.3 | 11.0 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
0.3 | 5.7 | GO:0071837 | HMG box domain binding(GO:0071837) |
0.3 | 18.3 | GO:0019003 | GDP binding(GO:0019003) |
0.3 | 12.4 | GO:0070888 | E-box binding(GO:0070888) |
0.2 | 2.5 | GO:0070700 | BMP receptor binding(GO:0070700) |
0.2 | 1.7 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
0.2 | 71.1 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
0.2 | 2.7 | GO:0038191 | neuropilin binding(GO:0038191) |
0.2 | 36.2 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
0.2 | 6.8 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
0.2 | 0.8 | GO:0004028 | 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028) |
0.1 | 6.1 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
0.1 | 2.9 | GO:0000400 | four-way junction DNA binding(GO:0000400) |
0.1 | 1.4 | GO:0043024 | ribosomal small subunit binding(GO:0043024) |
0.1 | 0.4 | GO:0005171 | hepatocyte growth factor receptor binding(GO:0005171) |
0.1 | 4.4 | GO:0005112 | Notch binding(GO:0005112) |
0.1 | 1.3 | GO:0070411 | I-SMAD binding(GO:0070411) |
0.1 | 2.2 | GO:0003785 | actin monomer binding(GO:0003785) |
0.1 | 55.3 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
0.1 | 0.8 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
0.1 | 1.1 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
0.1 | 2.6 | GO:0097602 | cullin family protein binding(GO:0097602) |
0.1 | 2.2 | GO:0001968 | fibronectin binding(GO:0001968) |
0.1 | 1.4 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
0.1 | 14.9 | GO:0051015 | actin filament binding(GO:0051015) |
0.1 | 1.1 | GO:0070628 | proteasome binding(GO:0070628) |
0.1 | 6.0 | GO:0032947 | protein complex scaffold(GO:0032947) |
0.1 | 1.4 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
0.1 | 1.9 | GO:0051059 | NF-kappaB binding(GO:0051059) |
0.1 | 0.9 | GO:0004029 | aldehyde dehydrogenase (NAD) activity(GO:0004029) |
0.1 | 3.9 | GO:0002039 | p53 binding(GO:0002039) |
0.1 | 2.1 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
0.1 | 0.4 | GO:0051731 | polynucleotide 5'-hydroxyl-kinase activity(GO:0051731) |
0.1 | 1.0 | GO:0032183 | SUMO binding(GO:0032183) |
0.0 | 0.1 | GO:0019002 | GMP binding(GO:0019002) |
0.0 | 1.0 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
0.0 | 0.7 | GO:0001159 | core promoter proximal region DNA binding(GO:0001159) |
0.0 | 4.2 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
0.0 | 0.2 | GO:0004984 | olfactory receptor activity(GO:0004984) |
0.0 | 58.0 | GO:0003677 | DNA binding(GO:0003677) |
0.0 | 0.2 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
0.0 | 1.8 | GO:0005179 | hormone activity(GO:0005179) |
0.0 | 6.5 | GO:0005096 | GTPase activator activity(GO:0005096) |
0.0 | 0.4 | GO:0051959 | dynein light intermediate chain binding(GO:0051959) |
0.0 | 4.5 | GO:0008022 | protein C-terminus binding(GO:0008022) |
0.0 | 0.8 | GO:0045182 | translation regulator activity(GO:0045182) |
0.0 | 31.4 | GO:0003676 | nucleic acid binding(GO:0003676) |
0.0 | 4.1 | GO:0008017 | microtubule binding(GO:0008017) |
0.0 | 2.3 | GO:0005516 | calmodulin binding(GO:0005516) |
0.0 | 0.8 | GO:0020037 | heme binding(GO:0020037) |
0.0 | 0.8 | GO:0003713 | transcription coactivator activity(GO:0003713) |
0.0 | 1.8 | GO:0003682 | chromatin binding(GO:0003682) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.9 | 32.1 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
0.6 | 16.7 | PID_P38_MKK3_6PATHWAY | p38 MAPK signaling pathway |
0.5 | 6.8 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
0.3 | 7.4 | PID_IL27_PATHWAY | IL27-mediated signaling events |
0.3 | 19.8 | PID_IL4_2PATHWAY | IL4-mediated signaling events |
0.3 | 15.0 | PID_PS1_PATHWAY | Presenilin action in Notch and Wnt signaling |
0.3 | 18.3 | PID_FAK_PATHWAY | Signaling events mediated by focal adhesion kinase |
0.3 | 6.0 | PID_HIF1A_PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
0.2 | 6.7 | PID_FOXM1_PATHWAY | FOXM1 transcription factor network |
0.2 | 7.4 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
0.2 | 7.4 | PID_AP1_PATHWAY | AP-1 transcription factor network |
0.2 | 6.6 | ST_ERK1_ERK2_MAPK_PATHWAY | ERK1/ERK2 MAPK Pathway |
0.2 | 14.3 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
0.2 | 10.9 | PID_SMAD2_3NUCLEAR_PATHWAY | Regulation of nuclear SMAD2/3 signaling |
0.1 | 9.8 | PID_CDC42_PATHWAY | CDC42 signaling events |
0.1 | 6.8 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
0.1 | 0.8 | PID_IL5_PATHWAY | IL5-mediated signaling events |
0.1 | 2.7 | PID_AURORA_B_PATHWAY | Aurora B signaling |
0.1 | 3.8 | PID_CMYB_PATHWAY | C-MYB transcription factor network |
0.1 | 1.8 | PID_ERBB4_PATHWAY | ErbB4 signaling events |
0.0 | 1.3 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
0.0 | 2.7 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
0.0 | 3.2 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
0.0 | 0.4 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.6 | 93.3 | REACTOME_PACKAGING_OF_TELOMERE_ENDS | Genes involved in Packaging Of Telomere Ends |
2.2 | 18.0 | REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
1.4 | 5.5 | REACTOME_ETHANOL_OXIDATION | Genes involved in Ethanol oxidation |
1.1 | 18.3 | REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
0.9 | 13.0 | REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
0.8 | 11.0 | REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
0.7 | 9.8 | REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
0.5 | 3.2 | REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS | Genes involved in Regulation of gene expression in beta cells |
0.4 | 4.1 | REACTOME_CRMPS_IN_SEMA3A_SIGNALING | Genes involved in CRMPs in Sema3A signaling |
0.3 | 6.0 | REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
0.3 | 5.6 | REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
0.3 | 11.4 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
0.3 | 7.8 | REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
0.3 | 7.6 | REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
0.2 | 9.6 | REACTOME_GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
0.2 | 6.3 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
0.1 | 2.5 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
0.1 | 6.6 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
0.1 | 1.1 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
0.0 | 1.2 | REACTOME_AMYLOIDS | Genes involved in Amyloids |
0.0 | 2.2 | REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ | Genes involved in Response to elevated platelet cytosolic Ca2+ |
0.0 | 0.4 | REACTOME_INFLAMMASOMES | Genes involved in Inflammasomes |
0.0 | 2.0 | REACTOME_INTEGRATION_OF_ENERGY_METABOLISM | Genes involved in Integration of energy metabolism |
0.0 | 0.6 | REACTOME_MEIOTIC_SYNAPSIS | Genes involved in Meiotic Synapsis |