Motif ID: Sox17

Z-value: 0.466


Transcription factors associated with Sox17:

Gene SymbolEntrez IDGene Name
Sox17 ENSMUSG00000025902.7 Sox17

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox17mm10_v2_chr1_-_4496363_4496389-0.241.4e-01Click!


Activity profile for motif Sox17.

activity profile for motif Sox17


Sorted Z-values histogram for motif Sox17

Sorted Z-values for motif Sox17



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox17

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_23248264 4.408 ENSMUST00000031709.5
Fezf1
Fez family zinc finger 1
chr8_-_105471481 2.443 ENSMUST00000014990.6
Tppp3
tubulin polymerization-promoting protein family member 3
chr6_+_121245903 1.545 ENSMUST00000032198.9
Usp18
ubiquitin specific peptidase 18
chr1_+_52008210 1.433 ENSMUST00000027277.5
Stat4
signal transducer and activator of transcription 4
chr2_-_180889660 1.416 ENSMUST00000137629.1
Gm14342
predicted gene 14342
chr11_-_97775876 0.946 ENSMUST00000107576.1
1700001P01Rik
RIKEN cDNA 1700001P01 gene
chr19_+_55741810 0.826 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr2_+_102659213 0.791 ENSMUST00000111213.1
Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr14_+_50944499 0.785 ENSMUST00000178092.1
Pnp
purine-nucleoside phosphorylase
chr4_+_118961578 0.754 ENSMUST00000058651.4
Lao1
L-amino acid oxidase 1
chr5_-_107597577 0.682 ENSMUST00000100949.3
ENSMUST00000078021.6
Glmn

glomulin, FKBP associated protein

chr10_+_81821127 0.675 ENSMUST00000099439.3
Gm4767
predicted gene 4767
chr4_+_41903610 0.665 ENSMUST00000098128.3
Gm21541
predicted gene, 21541
chr10_+_81661998 0.645 ENSMUST00000105315.2
Gm10778
predicted gene 10778
chr6_-_148944750 0.638 ENSMUST00000111562.1
ENSMUST00000081956.5
Fam60a

family with sequence similarity 60, member A

chr4_-_42773993 0.581 ENSMUST00000095114.4
Ccl21a
chemokine (C-C motif) ligand 21A (serine)
chr11_-_86807624 0.556 ENSMUST00000018569.7
Dhx40
DEAH (Asp-Glu-Ala-His) box polypeptide 40
chrX_+_123103546 0.548 ENSMUST00000113348.1
3110007F17Rik
RIKEN cDNA 3110007F17 gene
chrX_+_123103489 0.529 ENSMUST00000113343.1
3110007F17Rik
RIKEN cDNA 3110007F17 gene
chr1_+_135729147 0.509 ENSMUST00000027677.7
Csrp1
cysteine and glycine-rich protein 1
chr5_-_107597533 0.471 ENSMUST00000124140.1
Glmn
glomulin, FKBP associated protein
chrX_+_48695004 0.456 ENSMUST00000033433.2
Rbmx2
RNA binding motif protein, X-linked 2
chr18_-_36197343 0.404 ENSMUST00000115713.1
ENSMUST00000115712.1
Nrg2

neuregulin 2

chr12_+_51348019 0.399 ENSMUST00000054308.6
G2e3
G2/M-phase specific E3 ubiquitin ligase
chr12_+_24708241 0.387 ENSMUST00000020980.5
Rrm2
ribonucleotide reductase M2
chr17_+_46428930 0.378 ENSMUST00000024764.5
ENSMUST00000165993.1
Crip3

cysteine-rich protein 3

chr8_+_4248188 0.370 ENSMUST00000110993.1
Gm14378
predicted gene 14378
chr15_-_96460838 0.366 ENSMUST00000047835.6
Scaf11
SR-related CTD-associated factor 11
chr10_-_30655859 0.363 ENSMUST00000092610.4
Ncoa7
nuclear receptor coactivator 7
chr9_+_66946057 0.362 ENSMUST00000040917.7
ENSMUST00000127896.1
Rps27l

ribosomal protein S27-like

chr2_+_18677002 0.352 ENSMUST00000028071.6
Bmi1
Bmi1 polycomb ring finger oncogene
chr10_+_59221945 0.333 ENSMUST00000182161.1
Sowahc
sosondowah ankyrin repeat domain family member C
chr7_-_127890918 0.299 ENSMUST00000121394.1
Prss53
protease, serine, 53
chr9_+_108392820 0.294 ENSMUST00000035234.4
1700102P08Rik
RIKEN cDNA 1700102P08 gene
chr11_-_77894096 0.259 ENSMUST00000017597.4
Pipox
pipecolic acid oxidase
chr8_-_94098811 0.256 ENSMUST00000034206.4
Bbs2
Bardet-Biedl syndrome 2 (human)
chr18_+_35599219 0.242 ENSMUST00000115734.1
Paip2
polyadenylate-binding protein-interacting protein 2
chr19_-_44107447 0.240 ENSMUST00000119591.1
ENSMUST00000026217.4
Chuk

conserved helix-loop-helix ubiquitous kinase

chr2_+_121456963 0.224 ENSMUST00000126764.1
Hypk
huntingtin interacting protein K
chr2_+_181187247 0.223 ENSMUST00000016488.6
ENSMUST00000108841.1
Ppdpf

pancreatic progenitor cell differentiation and proliferation factor homolog (zebrafish)RIKEN cDNA 2700038C09 gene

chr12_+_51348370 0.223 ENSMUST00000121521.1
G2e3
G2/M-phase specific E3 ubiquitin ligase
chr15_+_85205949 0.221 ENSMUST00000057410.7
ENSMUST00000109432.3
Fbln1

fibulin 1

chr2_-_127133909 0.221 ENSMUST00000110387.3
Ncaph
non-SMC condensin I complex, subunit H
chr15_+_74721193 0.212 ENSMUST00000070923.1
Them6
thioesterase superfamily member 6
chr11_+_78343475 0.201 ENSMUST00000002127.7
ENSMUST00000108295.1
Unc119

unc-119 homolog (C. elegans)

chr5_-_130002838 0.198 ENSMUST00000111308.1
ENSMUST00000111307.1
Gusb

glucuronidase, beta

chr11_+_78346666 0.198 ENSMUST00000100755.3
Unc119
unc-119 homolog (C. elegans)
chr5_-_123721007 0.190 ENSMUST00000031376.7
Zcchc8
zinc finger, CCHC domain containing 8
chr12_+_51348265 0.188 ENSMUST00000119211.1
G2e3
G2/M-phase specific E3 ubiquitin ligase
chr5_-_38502107 0.187 ENSMUST00000005238.6
Slc2a9
solute carrier family 2 (facilitated glucose transporter), member 9
chr10_-_128176568 0.158 ENSMUST00000092033.2
Rbms2
RNA binding motif, single stranded interacting protein 2
chr4_-_135971894 0.151 ENSMUST00000105852.1
Lypla2
lysophospholipase 2
chr10_+_11609256 0.149 ENSMUST00000052902.7
Gm9797
predicted pseudogene 9797
chr9_+_82829806 0.149 ENSMUST00000113245.2
ENSMUST00000034783.4
Irak1bp1

interleukin-1 receptor-associated kinase 1 binding protein 1

chr2_-_57113053 0.146 ENSMUST00000112627.1
Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr10_+_93453382 0.146 ENSMUST00000016033.7
Lta4h
leukotriene A4 hydrolase
chr2_+_55411790 0.140 ENSMUST00000155997.1
ENSMUST00000128307.1
Gm14033

predicted gene 14033

chr14_+_68083853 0.137 ENSMUST00000022639.7
Nefl
neurofilament, light polypeptide
chr12_-_84400851 0.132 ENSMUST00000117286.1
Entpd5
ectonucleoside triphosphate diphosphohydrolase 5
chr14_+_31134853 0.123 ENSMUST00000090212.4
Nt5dc2
5'-nucleotidase domain containing 2
chr19_+_8920358 0.120 ENSMUST00000096243.5
B3gat3
beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)
chr2_+_155751117 0.116 ENSMUST00000029140.5
ENSMUST00000132608.1
Procr

protein C receptor, endothelial

chr10_+_80249106 0.115 ENSMUST00000105364.1
Ndufs7
NADH dehydrogenase (ubiquinone) Fe-S protein 7
chr3_-_158016419 0.106 ENSMUST00000127778.1
Srsf11
serine/arginine-rich splicing factor 11
chr7_-_100656953 0.104 ENSMUST00000107046.1
ENSMUST00000107045.1
ENSMUST00000139708.1
Plekhb1


pleckstrin homology domain containing, family B (evectins) member 1


chr10_+_14523062 0.102 ENSMUST00000096020.5
Gm10335
predicted gene 10335
chr2_-_142901506 0.091 ENSMUST00000043589.7
Kif16b
kinesin family member 16B
chr9_+_57521232 0.084 ENSMUST00000000090.6
Cox5a
cytochrome c oxidase subunit Va
chr12_-_84400929 0.082 ENSMUST00000122194.1
Entpd5
ectonucleoside triphosphate diphosphohydrolase 5
chr2_+_180598219 0.073 ENSMUST00000103059.1
Col9a3
collagen, type IX, alpha 3
chr17_-_55712571 0.062 ENSMUST00000086876.5
Pot1b
protection of telomeres 1B
chr7_+_29238323 0.061 ENSMUST00000108238.1
ENSMUST00000032809.3
ENSMUST00000138128.1
Yif1b


Yip1 interacting factor homolog B (S. cerevisiae)


chr5_+_26817357 0.057 ENSMUST00000071500.6
Dpp6
dipeptidylpeptidase 6
chr4_-_119173849 0.052 ENSMUST00000052715.4
ENSMUST00000179290.1
ENSMUST00000154226.1
Zfp691


zinc finger protein 691


chr8_+_107150621 0.048 ENSMUST00000034400.3
Cyb5b
cytochrome b5 type B
chr18_-_33213832 0.046 ENSMUST00000025236.2
Stard4
StAR-related lipid transfer (START) domain containing 4
chr12_+_84970897 0.046 ENSMUST00000021669.8
ENSMUST00000171040.1
Fcf1

FCF1 small subunit (SSU) processome component homolog (S. cerevisiae)

chr7_-_143549055 0.037 ENSMUST00000072727.5
Nap1l4
nucleosome assembly protein 1-like 4
chr14_+_73142490 0.034 ENSMUST00000170370.1
ENSMUST00000164822.1
ENSMUST00000165429.1
Rcbtb2


regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2


chr7_+_126976338 0.030 ENSMUST00000032920.3
Cdipt
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)
chr18_+_60560730 0.028 ENSMUST00000025506.6
Rbm22
RNA binding motif protein 22
chr7_+_16959714 0.010 ENSMUST00000038163.6
Pnmal1
PNMA-like 1
chr15_+_27025386 0.002 ENSMUST00000169678.2
Gm6576
predicted gene 6576
chr8_+_71887264 0.001 ENSMUST00000034259.7
Zfp709
zinc finger protein 709

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 4.4 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.3 0.8 GO:0046122 purine deoxyribonucleoside metabolic process(GO:0046122)
0.2 0.6 GO:0097026 dendritic cell dendrite assembly(GO:0097026)
0.2 1.5 GO:0080184 response to stilbenoid(GO:0035634) response to phenylpropanoid(GO:0080184)
0.1 1.2 GO:0045086 positive regulation of interleukin-2 biosynthetic process(GO:0045086)
0.1 0.4 GO:0033092 positive regulation of immature T cell proliferation in thymus(GO:0033092)
0.1 0.8 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.1 0.8 GO:0048625 myoblast fate commitment(GO:0048625)
0.1 0.3 GO:0006553 lysine metabolic process(GO:0006553)
0.1 0.4 GO:1900186 negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of caveolin-mediated endocytosis(GO:2001286)
0.1 0.2 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931) transforming growth factor-beta secretion(GO:0038044) blood coagulation, fibrin clot formation(GO:0072378)
0.1 0.2 GO:2000373 regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
0.1 0.3 GO:0038108 negative regulation of appetite by leptin-mediated signaling pathway(GO:0038108)
0.0 0.1 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.0 0.1 GO:0051866 general adaptation syndrome(GO:0051866)
0.0 0.4 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 0.2 GO:1902741 type I interferon secretion(GO:0072641) interferon-alpha secretion(GO:0072642) regulation of interferon-alpha secretion(GO:1902739) positive regulation of interferon-alpha secretion(GO:1902741)
0.0 0.2 GO:0046415 urate metabolic process(GO:0046415)
0.0 2.4 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 0.2 GO:0098734 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.0 0.1 GO:0050651 dermatan sulfate proteoglycan biosynthetic process(GO:0050651)
0.0 0.4 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.0 0.1 GO:0019370 leukotriene biosynthetic process(GO:0019370)
0.0 0.1 GO:0048239 negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695)
0.0 0.2 GO:0031017 exocrine pancreas development(GO:0031017)
0.0 0.4 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.2 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 0.0 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.0 0.8 GO:0009063 cellular amino acid catabolic process(GO:0009063)
0.0 0.2 GO:0030813 positive regulation of nucleotide catabolic process(GO:0030813) positive regulation of glycolytic process(GO:0045821) positive regulation of cofactor metabolic process(GO:0051194) positive regulation of coenzyme metabolic process(GO:0051197)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.4 GO:0097427 microtubule bundle(GO:0097427)
0.1 0.8 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 1.2 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.1 0.4 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.1 0.2 GO:0071953 fibrinogen complex(GO:0005577) elastic fiber(GO:0071953)
0.1 0.2 GO:0000799 nuclear condensin complex(GO:0000799)
0.0 0.1 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.0 0.6 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.3 GO:0034464 BBSome(GO:0034464)
0.0 0.5 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.2 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.1 GO:0005594 collagen type IX trimer(GO:0005594)
0.0 0.4 GO:0051233 spindle midzone(GO:0051233)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0005171 hepatocyte growth factor receptor binding(GO:0005171)
0.3 0.8 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.3 0.8 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.1 0.4 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.1 0.8 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 0.2 GO:0008384 IkappaB kinase activity(GO:0008384)
0.1 0.4 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.1 0.3 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.1 0.4 GO:0008494 translation activator activity(GO:0008494)
0.0 0.2 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0 0.2 GO:0070051 fibrinogen binding(GO:0070051)
0.0 0.2 GO:0004382 guanosine-diphosphatase activity(GO:0004382)
0.0 0.8 GO:0070016 gamma-catenin binding(GO:0045295) armadillo repeat domain binding(GO:0070016)
0.0 0.2 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.0 0.4 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.0 0.1 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.0 0.1 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.0 4.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.6 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 0.2 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.2 GO:0090079 translation repressor activity, nucleic acid binding(GO:0000900) translation regulator activity, nucleic acid binding(GO:0090079)
0.0 1.2 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 PID_IL27_PATHWAY IL27-mediated signaling events
0.0 0.4 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.8 PID_AP1_PATHWAY AP-1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 REACTOME_REGULATION_OF_IFNA_SIGNALING Genes involved in Regulation of IFNA signaling
0.1 0.8 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.0 0.2 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.4 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.2 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.4 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 0.2 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.8 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters