Motif ID: Irf5_Irf6

Z-value: 0.665

Transcription factors associated with Irf5_Irf6:

Gene SymbolEntrez IDGene Name
Irf5 ENSMUSG00000029771.6 Irf5
Irf6 ENSMUSG00000026638.9 Irf6






Network of associatons between targets according to the STRING database.



First level regulatory network of Irf5_Irf6

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_141010759 3.721 ENSMUST00000026565.6
Ifitm3
interferon induced transmembrane protein 3
chr4_-_40239779 3.625 ENSMUST00000037907.6
Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr17_-_6782775 3.070 ENSMUST00000064234.6
Ezr
ezrin
chr6_-_39118211 2.918 ENSMUST00000038398.6
Parp12
poly (ADP-ribose) polymerase family, member 12
chr11_+_88999376 2.189 ENSMUST00000100627.2
ENSMUST00000107896.3
ENSMUST00000000284.6
Trim25


tripartite motif-containing 25


chr4_-_40239700 1.882 ENSMUST00000142055.1
Ddx58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr16_+_35938972 1.862 ENSMUST00000023622.6
ENSMUST00000114877.1
Parp9

poly (ADP-ribose) polymerase family, member 9

chr2_-_77519565 1.798 ENSMUST00000111830.2
Zfp385b
zinc finger protein 385B
chr3_+_138065052 1.683 ENSMUST00000163080.2
1110002E22Rik
RIKEN cDNA 1110002E22 gene
chr4_-_136886187 1.536 ENSMUST00000046384.8
C1qb
complement component 1, q subcomponent, beta polypeptide
chr7_+_49246131 1.308 ENSMUST00000064395.6
Nav2
neuron navigator 2
chr19_+_55741810 1.250 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr11_+_72689997 1.227 ENSMUST00000155998.1
Ankfy1
ankyrin repeat and FYVE domain containing 1
chr9_+_45042425 1.173 ENSMUST00000034600.4
Mpzl2
myelin protein zero-like 2
chr9_+_57072024 0.898 ENSMUST00000169879.1
Sin3a
transcriptional regulator, SIN3A (yeast)
chr16_+_35938470 0.784 ENSMUST00000114878.1
Parp9
poly (ADP-ribose) polymerase family, member 9
chrX_-_95444789 0.709 ENSMUST00000084535.5
Amer1
APC membrane recruitment 1
chr16_-_67620805 0.704 ENSMUST00000120594.1
Cadm2
cell adhesion molecule 2
chr15_+_9436028 0.675 ENSMUST00000042360.3
Capsl
calcyphosine-like
chr12_-_31950170 0.673 ENSMUST00000176520.1
Hbp1
high mobility group box transcription factor 1
chr12_-_31950210 0.670 ENSMUST00000176084.1
ENSMUST00000176103.1
ENSMUST00000167458.2
Hbp1


high mobility group box transcription factor 1


chr16_-_67620880 0.638 ENSMUST00000114292.1
ENSMUST00000120898.1
Cadm2

cell adhesion molecule 2

chr1_-_163313661 0.614 ENSMUST00000174397.1
ENSMUST00000075805.6
ENSMUST00000027878.7
Prrx1


paired related homeobox 1


chr9_+_20868628 0.574 ENSMUST00000043911.7
A230050P20Rik
RIKEN cDNA A230050P20 gene
chr17_+_23679363 0.535 ENSMUST00000024699.2
Cldn6
claudin 6
chrX_+_77511002 0.520 ENSMUST00000088217.5
Tbl1x
transducin (beta)-like 1 X-linked
chr1_+_52119438 0.520 ENSMUST00000070968.7
Stat1
signal transducer and activator of transcription 1
chr2_-_77170592 0.514 ENSMUST00000164114.2
ENSMUST00000049544.7
Ccdc141

coiled-coil domain containing 141

chr9_+_95954744 0.459 ENSMUST00000034981.7
Xrn1
5'-3' exoribonuclease 1
chr9_-_123851855 0.452 ENSMUST00000184082.1
ENSMUST00000167595.2
Fyco1

FYVE and coiled-coil domain containing 1

chr12_+_26469204 0.391 ENSMUST00000020969.3
Cmpk2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr12_-_31950535 0.370 ENSMUST00000172314.2
Hbp1
high mobility group box transcription factor 1
chr6_-_13608011 0.358 ENSMUST00000031554.2
Tmem168
transmembrane protein 168
chr16_-_5255923 0.353 ENSMUST00000139584.1
ENSMUST00000064635.5
Fam86

family with sequence similarity 86

chr7_-_141266415 0.335 ENSMUST00000106023.1
ENSMUST00000097952.2
ENSMUST00000026571.4
Irf7


interferon regulatory factor 7


chr9_-_14381242 0.332 ENSMUST00000167549.1
Endod1
endonuclease domain containing 1
chr8_-_105568298 0.325 ENSMUST00000005849.5
Agrp
agouti related protein
chr7_+_128523576 0.322 ENSMUST00000033136.7
Bag3
BCL2-associated athanogene 3
chr12_-_78980758 0.318 ENSMUST00000174072.1
Tmem229b
transmembrane protein 229B
chr2_-_69586021 0.286 ENSMUST00000100051.2
ENSMUST00000092551.4
ENSMUST00000080953.5
Lrp2


low density lipoprotein receptor-related protein 2


chr17_+_34203527 0.273 ENSMUST00000025197.5
Tap2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
chr17_-_78882508 0.249 ENSMUST00000024884.4
Eif2ak2
eukaryotic translation initiation factor 2-alpha kinase 2
chrM_+_8600 0.243 ENSMUST00000082409.1
mt-Co3
mitochondrially encoded cytochrome c oxidase III
chr10_-_43174521 0.184 ENSMUST00000040275.7
Sobp
sine oculis-binding protein homolog (Drosophila)
chr9_+_55326913 0.184 ENSMUST00000085754.3
ENSMUST00000034862.4
AI118078

expressed sequence AI118078

chr15_-_76243401 0.165 ENSMUST00000165738.1
ENSMUST00000075689.6
Parp10

poly (ADP-ribose) polymerase family, member 10

chr2_-_51934644 0.161 ENSMUST00000165313.1
Rbm43
RNA binding motif protein 43
chr11_-_78984831 0.153 ENSMUST00000073001.4
ENSMUST00000108269.3
Lgals9

lectin, galactose binding, soluble 9

chr11_+_69966896 0.145 ENSMUST00000151515.1
Cldn7
claudin 7
chr7_-_65370908 0.129 ENSMUST00000032729.6
Tjp1
tight junction protein 1
chr19_-_7295394 0.127 ENSMUST00000025921.8
Mark2
MAP/microtubule affinity-regulating kinase 2
chr1_-_105356658 0.113 ENSMUST00000058688.5
ENSMUST00000172299.1
Rnf152

ring finger protein 152

chrM_+_9452 0.110 ENSMUST00000082411.1
mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chr15_+_96287518 0.108 ENSMUST00000134985.2
ENSMUST00000096250.4
Arid2

AT rich interactive domain 2 (ARID, RFX-like)

chr5_-_24447587 0.103 ENSMUST00000127194.1
ENSMUST00000115033.1
ENSMUST00000123167.1
ENSMUST00000030799.8
Tmub1



transmembrane and ubiquitin-like domain containing 1



chr7_-_126396715 0.099 ENSMUST00000075671.4
Nfatc2ip
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 interacting protein
chr17_+_34644805 0.077 ENSMUST00000174796.1
Fkbpl
FK506 binding protein-like
chr11_-_78984946 0.063 ENSMUST00000108268.3
Lgals9
lectin, galactose binding, soluble 9
chr9_-_123862023 0.054 ENSMUST00000182350.1
ENSMUST00000078755.2
Xcr1

chemokine (C motif) receptor 1

chr4_-_58911902 0.021 ENSMUST00000134848.1
ENSMUST00000107557.2
ENSMUST00000149301.1
AI314180


expressed sequence AI314180


chr6_-_87838671 0.014 ENSMUST00000089497.4
Isy1
ISY1 splicing factor homolog (S. cerevisiae)
chr16_-_35871544 0.012 ENSMUST00000042665.8
Parp14
poly (ADP-ribose) polymerase family, member 14

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 5.5 GO:0009597 detection of virus(GO:0009597)
1.0 3.1 GO:1900041 intestinal D-glucose absorption(GO:0001951) negative regulation of interleukin-2 secretion(GO:1900041) terminal web assembly(GO:1902896)
0.3 1.3 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
0.3 5.9 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.3 0.9 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.3 2.6 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
0.2 1.2 GO:0032439 endosome localization(GO:0032439) positive regulation of pinocytosis(GO:0048549)
0.2 1.7 GO:0010745 negative regulation of macrophage derived foam cell differentiation(GO:0010745)
0.2 1.3 GO:0048625 myoblast fate commitment(GO:0048625)
0.1 0.4 GO:0046077 dUDP biosynthetic process(GO:0006227) pyrimidine nucleoside diphosphate metabolic process(GO:0009138) pyrimidine nucleoside diphosphate biosynthetic process(GO:0009139) pyrimidine deoxyribonucleoside diphosphate metabolic process(GO:0009196) pyrimidine deoxyribonucleoside diphosphate biosynthetic process(GO:0009197) dUDP metabolic process(GO:0046077)
0.1 0.5 GO:0034239 regulation of macrophage fusion(GO:0034239)
0.1 0.7 GO:2001012 mesenchymal cell differentiation involved in kidney development(GO:0072161) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.1 0.5 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
0.1 0.3 GO:0002489 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489)
0.1 1.5 GO:0006958 complement activation, classical pathway(GO:0006958)
0.1 0.2 GO:1902714 negative regulation of interferon-gamma secretion(GO:1902714)
0.1 0.3 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
0.1 0.2 GO:1902915 negative regulation of protein import into nucleus, translocation(GO:0033159) negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.0 0.6 GO:0048664 neuron fate determination(GO:0048664)
0.0 0.5 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
0.0 0.3 GO:0008343 adult feeding behavior(GO:0008343)
0.0 0.2 GO:1900225 NLRP3 inflammasome complex assembly(GO:0044546) regulation of NLRP3 inflammasome complex assembly(GO:1900225)
0.0 1.3 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.6 GO:0034340 response to type I interferon(GO:0034340)
0.0 0.3 GO:0044872 lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)
0.0 0.3 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.0 1.8 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.0 1.1 GO:0071594 T cell differentiation in thymus(GO:0033077) thymocyte aggregation(GO:0071594)
0.0 0.1 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.5 GO:0051642 centrosome localization(GO:0051642)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.1 GO:0098592 cytoplasmic side of apical plasma membrane(GO:0098592)
0.2 1.2 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.1 1.3 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 1.3 GO:0005614 interstitial matrix(GO:0005614)
0.1 0.3 GO:0005796 Golgi lumen(GO:0005796)
0.1 5.5 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.9 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.3 GO:0042825 TAP complex(GO:0042825)
0.0 0.8 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 1.3 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 1.5 GO:0005581 collagen trimer(GO:0005581)
0.0 0.1 GO:0097427 microtubule bundle(GO:0097427)
0.0 1.8 GO:0001650 fibrillar center(GO:0001650)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.7 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.2 3.1 GO:0044548 S100 protein binding(GO:0044548)
0.2 0.5 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.1 0.4 GO:0004127 cytidylate kinase activity(GO:0004127) uridylate kinase activity(GO:0009041)
0.1 2.2 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.1 0.3 GO:0042954 lipoprotein transporter activity(GO:0042954)
0.1 5.8 GO:0003725 double-stranded RNA binding(GO:0003725)
0.1 0.3 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
0.1 1.3 GO:0070016 gamma-catenin binding(GO:0045295) armadillo repeat domain binding(GO:0070016)
0.1 0.5 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.0 0.5 GO:0001618 virus receptor activity(GO:0001618)
0.0 0.2 GO:0016936 galactoside binding(GO:0016936)
0.0 0.3 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.9 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.2 GO:0032184 SUMO polymer binding(GO:0032184)
0.0 1.8 GO:0002039 p53 binding(GO:0002039)
0.0 0.6 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.3 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.5 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.1 GO:0071253 connexin binding(GO:0071253)
0.0 1.2 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.2 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 1.3 GO:0008201 heparin binding(GO:0008201)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.1 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.1 0.5 ST_TYPE_I_INTERFERON_PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.1 1.7 PID_MYC_PATHWAY C-MYC pathway
0.0 0.3 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 1.8 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.8 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.9 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.3 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 8.0 REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.3 1.5 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 3.7 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 3.1 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.0 1.3 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.1 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.5 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.7 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 0.3 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.0 0.5 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.3 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC