Motif ID: Gmeb1

Z-value: 0.624


Transcription factors associated with Gmeb1:

Gene SymbolEntrez IDGene Name
Gmeb1 ENSMUSG00000028901.7 Gmeb1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gmeb1mm10_v2_chr4_-_132261596_1322616220.287.7e-02Click!


Activity profile for motif Gmeb1.

activity profile for motif Gmeb1


Sorted Z-values histogram for motif Gmeb1

Sorted Z-values for motif Gmeb1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gmeb1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_94918012 4.143 ENSMUST00000077955.5
Ccdc102a
coiled-coil domain containing 102A
chr7_-_19310035 3.188 ENSMUST00000003640.2
Fosb
FBJ osteosarcoma oncogene B
chr1_+_175880775 3.052 ENSMUST00000039725.6
Exo1
exonuclease 1
chr19_+_43612299 3.018 ENSMUST00000057178.9
Nkx2-3
NK2 homeobox 3
chr6_+_113531675 2.664 ENSMUST00000036340.5
ENSMUST00000101051.2
Fancd2

Fanconi anemia, complementation group D2

chr3_+_40800054 2.664 ENSMUST00000168287.1
Plk4
polo-like kinase 4
chr2_-_157007039 2.577 ENSMUST00000103129.2
ENSMUST00000103130.1
Dsn1

DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)

chr15_+_99074968 2.451 ENSMUST00000039665.6
Troap
trophinin associated protein
chr3_+_40800013 2.417 ENSMUST00000026858.5
ENSMUST00000170825.1
Plk4

polo-like kinase 4

chr2_-_157007015 2.189 ENSMUST00000146413.1
Dsn1
DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)
chr11_-_40733373 1.634 ENSMUST00000020579.8
Hmmr
hyaluronan mediated motility receptor (RHAMM)
chr3_+_127553462 1.532 ENSMUST00000043108.4
4930422G04Rik
RIKEN cDNA 4930422G04 gene
chr11_-_100822525 1.454 ENSMUST00000107358.2
Stat5b
signal transducer and activator of transcription 5B
chr17_+_84511832 1.411 ENSMUST00000047206.5
Plekhh2
pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
chr7_+_35397046 1.330 ENSMUST00000079414.5
Cep89
centrosomal protein 89
chr8_-_45333189 1.271 ENSMUST00000095328.4
Cyp4v3
cytochrome P450, family 4, subfamily v, polypeptide 3
chr3_-_138143352 1.245 ENSMUST00000098580.2
Mttp
microsomal triglyceride transfer protein
chrX_+_112311334 1.099 ENSMUST00000026599.3
ENSMUST00000113415.1
Apool

apolipoprotein O-like

chr17_+_23679363 1.037 ENSMUST00000024699.2
Cldn6
claudin 6
chr1_+_95313607 1.022 ENSMUST00000059975.6
Fam174a
family with sequence similarity 174, member A
chr3_+_138143429 0.921 ENSMUST00000040321.6
Trmt10a
tRNA methyltransferase 10A
chr15_-_81399594 0.880 ENSMUST00000023039.8
St13
suppression of tumorigenicity 13
chr3_+_138143483 0.827 ENSMUST00000162864.1
Trmt10a
tRNA methyltransferase 10A
chr2_+_75659253 0.827 ENSMUST00000111964.1
ENSMUST00000111962.1
ENSMUST00000111961.1
ENSMUST00000164947.2
ENSMUST00000090792.4
Hnrnpa3




heterogeneous nuclear ribonucleoprotein A3




chr4_+_55350043 0.804 ENSMUST00000030134.8
Rad23b
RAD23b homolog (S. cerevisiae)
chr11_+_86544982 0.780 ENSMUST00000108030.2
ENSMUST00000020821.3
ENSMUST00000069503.6
ENSMUST00000167178.2
Tubd1



tubulin, delta 1



chr11_+_40733639 0.721 ENSMUST00000020578.4
Nudcd2
NudC domain containing 2
chr4_+_128727585 0.658 ENSMUST00000106079.3
ENSMUST00000133439.1
Phc2

polyhomeotic-like 2 (Drosophila)

chr15_-_58135047 0.657 ENSMUST00000038194.3
Atad2
ATPase family, AAA domain containing 2
chr4_-_135353126 0.627 ENSMUST00000030613.4
ENSMUST00000131373.1
Srrm1

serine/arginine repetitive matrix 1

chr12_-_31654767 0.623 ENSMUST00000020977.2
Dus4l
dihydrouridine synthase 4-like (S. cerevisiae)
chr11_-_113751309 0.589 ENSMUST00000106616.1
Cdc42ep4
CDC42 effector protein (Rho GTPase binding) 4
chr11_+_53770458 0.588 ENSMUST00000138913.1
ENSMUST00000123376.1
ENSMUST00000019043.6
ENSMUST00000133291.1
Irf1



interferon regulatory factor 1



chr15_-_81400043 0.572 ENSMUST00000172107.1
ENSMUST00000169204.1
ENSMUST00000163382.1
St13


suppression of tumorigenicity 13


chr4_-_135353164 0.555 ENSMUST00000084846.5
ENSMUST00000136342.2
ENSMUST00000105861.1
Srrm1


serine/arginine repetitive matrix 1


chr3_+_95434386 0.410 ENSMUST00000102749.4
ENSMUST00000090804.5
ENSMUST00000107161.1
ENSMUST00000107160.1
ENSMUST00000015666.10
Arnt




aryl hydrocarbon receptor nuclear translocator




chr8_-_123949201 0.397 ENSMUST00000044795.7
Nup133
nucleoporin 133
chr4_-_72200833 0.364 ENSMUST00000102848.2
ENSMUST00000072695.6
ENSMUST00000107337.1
ENSMUST00000074216.7
Tle1



transducin-like enhancer of split 1, homolog of Drosophila E(spl)



chr13_-_53473074 0.358 ENSMUST00000021922.8
Msx2
msh homeobox 2
chr11_-_6626030 0.328 ENSMUST00000000394.7
ENSMUST00000136682.1
Tbrg4

transforming growth factor beta regulated gene 4

chr17_-_56626872 0.324 ENSMUST00000047226.8
Lonp1
lon peptidase 1, mitochondrial
chr4_-_126202583 0.303 ENSMUST00000106142.1
ENSMUST00000169403.1
ENSMUST00000130334.1
Thrap3


thyroid hormone receptor associated protein 3


chr10_-_81378459 0.298 ENSMUST00000140901.1
Fzr1
fizzy/cell division cycle 20 related 1 (Drosophila)
chr5_-_31291026 0.293 ENSMUST00000041565.7
Ift172
intraflagellar transport 172
chr9_+_48495345 0.280 ENSMUST00000048824.7
Gm5617
predicted gene 5617
chrX_+_150588223 0.244 ENSMUST00000153221.1
Pfkfb1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr11_+_69914179 0.236 ENSMUST00000057884.5
Gps2
G protein pathway suppressor 2
chr10_+_80798652 0.214 ENSMUST00000151928.1
Sf3a2
splicing factor 3a, subunit 2
chr11_-_97782409 0.206 ENSMUST00000103146.4
Rpl23
ribosomal protein L23
chr16_+_20548577 0.206 ENSMUST00000003319.5
Abcf3
ATP-binding cassette, sub-family F (GCN20), member 3
chr4_-_126202757 0.201 ENSMUST00000080919.5
Thrap3
thyroid hormone receptor associated protein 3
chr3_-_127553233 0.195 ENSMUST00000029588.5
Larp7
La ribonucleoprotein domain family, member 7
chr7_+_5020376 0.195 ENSMUST00000076251.4
Zfp865
zinc finger protein 865
chr8_-_25016901 0.187 ENSMUST00000084035.5
Adam9
a disintegrin and metallopeptidase domain 9 (meltrin gamma)
chr10_+_96616998 0.187 ENSMUST00000038377.7
Btg1
B cell translocation gene 1, anti-proliferative
chr14_+_32085804 0.183 ENSMUST00000170600.1
ENSMUST00000168986.1
ENSMUST00000169649.1
Oxnad1


oxidoreductase NAD-binding domain containing 1


chr13_+_23574381 0.166 ENSMUST00000090776.4
Hist1h2ad
histone cluster 1, H2ad
chr7_+_101663705 0.164 ENSMUST00000106998.1
Clpb
ClpB caseinolytic peptidase B
chr8_-_25016743 0.134 ENSMUST00000084032.5
Adam9
a disintegrin and metallopeptidase domain 9 (meltrin gamma)
chr11_-_97782377 0.116 ENSMUST00000128801.1
Rpl23
ribosomal protein L23
chr7_+_5020561 0.114 ENSMUST00000085427.3
Zfp865
zinc finger protein 865
chr15_-_99087817 0.100 ENSMUST00000064462.3
C1ql4
complement component 1, q subcomponent-like 4
chr4_-_40269778 0.097 ENSMUST00000042575.6
Topors
topoisomerase I binding, arginine/serine-rich
chr19_-_24477356 0.091 ENSMUST00000099556.1
Fam122a
family with sequence similarity 122, member A
chr15_+_81400132 0.085 ENSMUST00000163754.1
ENSMUST00000041609.4
Xpnpep3

X-prolyl aminopeptidase (aminopeptidase P) 3, putative

chr7_-_83884289 0.059 ENSMUST00000094216.3
Mesdc1
mesoderm development candidate 1
chr7_+_101663633 0.054 ENSMUST00000001884.7
Clpb
ClpB caseinolytic peptidase B
chr16_+_35022394 0.043 ENSMUST00000061156.8
Ptplb
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b
chr10_-_80798476 0.022 ENSMUST00000036805.5
Plekhj1
pleckstrin homology domain containing, family J member 1
chr9_-_45906837 0.015 ENSMUST00000161203.1
ENSMUST00000058720.5
ENSMUST00000160699.1
Rnf214


ring finger protein 214


chr1_-_160212864 0.014 ENSMUST00000014370.5
Cacybp
calcyclin binding protein
chr17_+_29549783 0.012 ENSMUST00000048677.7
Tbc1d22b
TBC1 domain family, member 22B
chr12_+_4917376 0.011 ENSMUST00000045664.5
Atad2b
ATPase family, AAA domain containing 2B
chr19_-_40588374 0.004 ENSMUST00000175932.1
ENSMUST00000176955.1
ENSMUST00000149476.2
Aldh18a1


aldehyde dehydrogenase 18 family, member A1



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.8 GO:0051316 attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation(GO:0051316)
0.7 5.1 GO:0098535 positive regulation of centriole replication(GO:0046601) de novo centriole assembly(GO:0098535)
0.5 3.0 GO:0002317 plasma cell differentiation(GO:0002317)
0.5 1.5 GO:0046544 regulation of natural killer cell proliferation(GO:0032817) positive regulation of natural killer cell proliferation(GO:0032819) development of secondary male sexual characteristics(GO:0046544)
0.4 2.7 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.3 3.1 GO:0016446 somatic hypermutation of immunoglobulin genes(GO:0016446)
0.3 0.8 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.2 1.2 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.2 0.6 GO:2000564 CD8-positive, alpha-beta T cell proliferation(GO:0035740) negative regulation of regulatory T cell differentiation(GO:0045590) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564)
0.2 1.5 GO:0061084 negative regulation of protein refolding(GO:0061084)
0.1 0.4 GO:0035880 embryonic nail plate morphogenesis(GO:0035880) positive regulation of catagen(GO:0051795) frontal suture morphogenesis(GO:0060364)
0.1 0.3 GO:0034241 positive regulation of macrophage fusion(GO:0034241)
0.1 1.1 GO:0042407 cristae formation(GO:0042407)
0.1 0.3 GO:0072717 cellular response to actinomycin D(GO:0072717)
0.1 0.7 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.1 1.7 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.1 3.2 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 0.6 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.0 0.4 GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972)
0.0 0.4 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.0 0.2 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.0 0.2 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 1.4 GO:0030835 negative regulation of actin filament depolymerization(GO:0030835)
0.0 0.3 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.0 0.5 GO:0042753 positive regulation of circadian rhythm(GO:0042753)
0.0 0.3 GO:0061525 hindgut development(GO:0061525) left/right axis specification(GO:0070986)
0.0 0.2 GO:0035562 negative regulation of chromatin binding(GO:0035562)
0.0 0.4 GO:2000811 negative regulation of anoikis(GO:2000811)
0.0 1.3 GO:0019395 fatty acid oxidation(GO:0019395)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.8 GO:0000939 nuclear MIS12/MIND complex(GO:0000818) condensed chromosome inner kinetochore(GO:0000939)
0.8 5.1 GO:0098536 deuterosome(GO:0098536)
0.2 0.8 GO:0071942 XPC complex(GO:0071942)
0.1 1.1 GO:0061617 MICOS complex(GO:0061617)
0.1 1.3 GO:0097539 ciliary transition fiber(GO:0097539)
0.1 0.2 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.1 1.2 GO:0031528 microvillus membrane(GO:0031528)
0.1 4.1 GO:0016459 myosin complex(GO:0016459)
0.0 1.0 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.8 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.7 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.4 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.3 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 2.7 GO:0000793 condensed chromosome(GO:0000793)
0.0 1.4 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.3 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.5 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.3 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.2 GO:0071004 U2 snRNP(GO:0005686) U2-type prespliceosome(GO:0071004)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.1 GO:0008309 double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
0.2 1.7 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.2 0.6 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.2 0.8 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.2 1.5 GO:0032564 dATP binding(GO:0032564)
0.1 3.0 GO:0070182 DNA polymerase binding(GO:0070182)
0.1 1.6 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 1.0 GO:0001618 virus receptor activity(GO:0001618)
0.1 0.4 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 1.2 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.3 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.0 0.3 GO:1990948 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.0 1.5 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.2 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.0 4.1 GO:0003774 motor activity(GO:0003774)
0.0 0.6 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 1.3 GO:0004497 monooxygenase activity(GO:0004497)
0.0 0.4 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.1 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.0 0.5 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.0 0.8 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 0.4 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.3 GO:0043236 laminin binding(GO:0043236)
0.0 3.8 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 PID_IL5_PATHWAY IL5-mediated signaling events
0.1 2.7 PID_BARD1_PATHWAY BARD1 signaling events
0.0 3.2 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 0.6 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 0.4 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.7 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.2 1.6 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 1.5 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.1 1.2 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 4.3 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 4.6 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.8 REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER Genes involved in Formation of incision complex in GG-NER
0.0 1.0 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 0.6 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.4 REACTOME_REGULATION_OF_HYPOXIA_INDUCIBLE_FACTOR_HIF_BY_OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.0 0.5 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.0 1.0 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing