Motif ID: Tbx21

Z-value: 0.951


Transcription factors associated with Tbx21:

Gene SymbolEntrez IDGene Name
Tbx21 ENSMUSG00000001444.2 Tbx21



Activity profile for motif Tbx21.

activity profile for motif Tbx21


Sorted Z-values histogram for motif Tbx21

Sorted Z-values for motif Tbx21



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx21

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_56969864 4.647 ENSMUST00000177424.1
Satb2
special AT-rich sequence binding protein 2
chr9_-_112185726 4.557 ENSMUST00000160240.1
ENSMUST00000162065.1
Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr1_-_56969827 4.096 ENSMUST00000176759.1
Satb2
special AT-rich sequence binding protein 2
chr6_-_101377897 4.013 ENSMUST00000075994.6
Pdzrn3
PDZ domain containing RING finger 3
chr2_-_66440753 3.667 ENSMUST00000112371.2
ENSMUST00000138910.1
Scn1a

sodium channel, voltage-gated, type I, alpha

chr9_-_112185939 3.374 ENSMUST00000070218.5
Arpp21
cyclic AMP-regulated phosphoprotein, 21
chr18_+_37020097 2.893 ENSMUST00000047614.1
Pcdha2
protocadherin alpha 2
chr7_+_45785331 2.861 ENSMUST00000120005.1
ENSMUST00000123585.1
Lmtk3

lemur tyrosine kinase 3

chr10_-_13868932 2.833 ENSMUST00000019942.5
ENSMUST00000162610.1
Aig1

androgen-induced 1

chr5_-_138619702 2.777 ENSMUST00000063262.4
Zfp68
zinc finger protein 68
chr6_-_60829826 2.766 ENSMUST00000163779.1
Snca
synuclein, alpha
chr8_+_12984246 2.633 ENSMUST00000110873.3
ENSMUST00000173006.1
ENSMUST00000145067.1
Mcf2l


mcf.2 transforming sequence-like


chr5_-_138619751 2.623 ENSMUST00000085852.4
ENSMUST00000110905.2
Zfp68

zinc finger protein 68

chr18_+_67088287 2.608 ENSMUST00000025402.7
Gnal
guanine nucleotide binding protein, alpha stimulating, olfactory type
chr19_+_44989073 2.600 ENSMUST00000026225.8
Sema4g
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr10_-_13868779 2.543 ENSMUST00000105534.3
Aig1
androgen-induced 1
chr5_-_138619653 2.512 ENSMUST00000129832.1
Zfp68
zinc finger protein 68
chr5_+_98180866 2.434 ENSMUST00000112959.1
Prdm8
PR domain containing 8
chr1_+_59912972 2.385 ENSMUST00000036540.5
Fam117b
family with sequence similarity 117, member B
chr6_-_50261943 2.346 ENSMUST00000167893.1
Dfna5
deafness, autosomal dominant 5 (human)
chr1_+_34801704 2.341 ENSMUST00000047664.9
Arhgef4
Rho guanine nucleotide exchange factor (GEF) 4
chr3_-_127499095 2.335 ENSMUST00000182594.1
Ank2
ankyrin 2, brain
chr15_-_84105662 2.220 ENSMUST00000082365.5
Sult4a1
sulfotransferase family 4A, member 1
chr6_-_50261743 2.065 ENSMUST00000101405.3
ENSMUST00000165099.1
ENSMUST00000170142.1
Dfna5


deafness, autosomal dominant 5 (human)


chr14_-_100149764 2.005 ENSMUST00000097079.4
Klf12
Kruppel-like factor 12
chr18_+_37742088 1.976 ENSMUST00000003599.6
Pcdhga9
protocadherin gamma subfamily A, 9
chr11_+_24080664 1.975 ENSMUST00000118955.1
Bcl11a
B cell CLL/lymphoma 11A (zinc finger protein)
chr17_+_6270475 1.908 ENSMUST00000088940.4
Tmem181a
transmembrane protein 181A
chr2_+_28641227 1.889 ENSMUST00000028155.5
ENSMUST00000113869.1
ENSMUST00000113867.2
Tsc1


tuberous sclerosis 1


chr9_-_86546795 1.883 ENSMUST00000167814.1
Gm17530
predicted gene, 17530
chr6_-_142964404 1.858 ENSMUST00000032421.3
St8sia1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr5_-_39644597 1.857 ENSMUST00000152057.1
Hs3st1
heparan sulfate (glucosamine) 3-O-sulfotransferase 1
chr11_+_103171081 1.816 ENSMUST00000042286.5
Fmnl1
formin-like 1
chrX_+_74297097 1.742 ENSMUST00000019231.5
ENSMUST00000147900.1
ENSMUST00000147275.1
ENSMUST00000114171.3
Atp6ap1



ATPase, H+ transporting, lysosomal accessory protein 1



chr1_+_179546303 1.708 ENSMUST00000040706.8
Cnst
consortin, connexin sorting protein
chr16_-_4003750 1.609 ENSMUST00000171658.1
ENSMUST00000171762.1
Slx4

SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)

chr1_+_62703667 1.600 ENSMUST00000114155.1
ENSMUST00000027112.6
ENSMUST00000063594.6
ENSMUST00000114157.2
Nrp2



neuropilin 2



chr7_+_27607997 1.490 ENSMUST00000142365.1
Akt2
thymoma viral proto-oncogene 2
chrX_-_136868537 1.479 ENSMUST00000058814.6
Rab9b
RAB9B, member RAS oncogene family
chr17_-_33713372 1.448 ENSMUST00000173392.1
March2
membrane-associated ring finger (C3HC4) 2
chr12_-_4874341 1.398 ENSMUST00000137337.1
ENSMUST00000045921.7
Mfsd2b

major facilitator superfamily domain containing 2B

chr5_-_39644634 1.379 ENSMUST00000053116.6
Hs3st1
heparan sulfate (glucosamine) 3-O-sulfotransferase 1
chr1_+_62703285 1.371 ENSMUST00000102822.2
ENSMUST00000075144.5
Nrp2

neuropilin 2

chr1_+_60409612 1.370 ENSMUST00000052332.8
Abi2
abl-interactor 2
chrX_-_95444789 1.321 ENSMUST00000084535.5
Amer1
APC membrane recruitment 1
chr19_+_46573362 1.312 ENSMUST00000026011.6
Sfxn2
sideroflexin 2
chr10_+_7792891 1.311 ENSMUST00000015901.4
Ppil4
peptidylprolyl isomerase (cyclophilin)-like 4
chr2_-_167043494 1.302 ENSMUST00000067584.6
Znfx1
zinc finger, NFX1-type containing 1
chr5_-_24730635 1.294 ENSMUST00000068693.5
Wdr86
WD repeat domain 86
chr5_-_36582381 1.261 ENSMUST00000141043.1
ENSMUST00000031094.8
Tbc1d14

TBC1 domain family, member 14

chr14_+_64588112 1.258 ENSMUST00000181808.1
A930011O12Rik
RIKEN cDNA A930011O12 gene
chr8_-_105701077 1.258 ENSMUST00000042608.6
Acd
adrenocortical dysplasia
chr10_-_75560330 1.249 ENSMUST00000051129.9
Fam211b
family with sequence similarity 211, member B
chr9_-_106656081 1.249 ENSMUST00000023959.7
Grm2
glutamate receptor, metabotropic 2
chr11_-_65162904 1.230 ENSMUST00000093002.5
ENSMUST00000047463.8
Arhgap44

Rho GTPase activating protein 44

chr7_+_27607748 1.185 ENSMUST00000136962.1
Akt2
thymoma viral proto-oncogene 2
chr4_+_74242468 1.174 ENSMUST00000077851.3
Kdm4c
lysine (K)-specific demethylase 4C
chr9_-_85749308 1.160 ENSMUST00000039213.8
Ibtk
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr4_+_109000770 1.107 ENSMUST00000106644.2
Nrd1
nardilysin, N-arginine dibasic convertase, NRD convertase 1
chr3_-_94436574 1.106 ENSMUST00000029787.4
Oaz3
ornithine decarboxylase antizyme 3
chr8_+_25849618 1.100 ENSMUST00000098858.3
Kcnu1
potassium channel, subfamily U, member 1
chr11_-_118248590 1.056 ENSMUST00000106305.2
Cyth1
cytohesin 1
chr3_+_106684943 1.053 ENSMUST00000098751.3
Lrif1
ligand dependent nuclear receptor interacting factor 1
chr19_+_34192229 1.039 ENSMUST00000054956.8
Stambpl1
STAM binding protein like 1
chr13_+_21945084 1.022 ENSMUST00000176511.1
ENSMUST00000102978.1
ENSMUST00000152258.2
Zfp184


zinc finger protein 184 (Kruppel-like)


chr2_+_164823001 1.020 ENSMUST00000132282.1
Zswim1
zinc finger SWIM-type containing 1
chr7_-_29954049 1.012 ENSMUST00000108211.1
ENSMUST00000108205.1
Zfp74

zinc finger protein 74

chr11_-_74590186 0.981 ENSMUST00000102521.1
Rap1gap2
RAP1 GTPase activating protein 2
chr16_-_20426322 0.979 ENSMUST00000115547.2
ENSMUST00000096199.4
Abcc5

ATP-binding cassette, sub-family C (CFTR/MRP), member 5

chr13_+_104178797 0.978 ENSMUST00000022225.5
ENSMUST00000069187.5
Trim23

tripartite motif-containing 23

chr6_-_38124568 0.975 ENSMUST00000040259.4
Atp6v0a4
ATPase, H+ transporting, lysosomal V0 subunit A4
chr9_+_55326913 0.974 ENSMUST00000085754.3
ENSMUST00000034862.4
AI118078

expressed sequence AI118078

chr1_-_152090308 0.919 ENSMUST00000044581.7
1700025G04Rik
RIKEN cDNA 1700025G04 gene
chr11_+_22971991 0.903 ENSMUST00000049506.5
Zrsr1
zinc finger (CCCH type), RNA binding motif and serine/arginine rich 1
chr1_+_153874335 0.882 ENSMUST00000055314.3
Gm5531
predicted gene 5531
chr9_-_35558522 0.882 ENSMUST00000034612.5
Ddx25
DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
chr7_-_126704816 0.870 ENSMUST00000032949.7
Coro1a
coronin, actin binding protein 1A
chr16_-_20425881 0.869 ENSMUST00000077867.3
Abcc5
ATP-binding cassette, sub-family C (CFTR/MRP), member 5
chr17_-_56074542 0.866 ENSMUST00000139371.1
Ubxn6
UBX domain protein 6
chr3_-_63964659 0.828 ENSMUST00000161659.1
Slc33a1
solute carrier family 33 (acetyl-CoA transporter), member 1
chr11_-_120643643 0.814 ENSMUST00000141254.1
ENSMUST00000170556.1
ENSMUST00000151876.1
ENSMUST00000026133.8
ENSMUST00000139706.1
Pycr1




pyrroline-5-carboxylate reductase 1




chr11_+_88047302 0.793 ENSMUST00000139129.2
Srsf1
serine/arginine-rich splicing factor 1
chr11_-_74590065 0.762 ENSMUST00000145524.1
ENSMUST00000047488.7
Rap1gap2

RAP1 GTPase activating protein 2

chr4_+_154869585 0.730 ENSMUST00000079269.7
ENSMUST00000163732.1
ENSMUST00000080559.6
Mmel1


membrane metallo-endopeptidase-like 1


chr12_-_102439813 0.729 ENSMUST00000021607.8
Lgmn
legumain
chr3_-_89322883 0.726 ENSMUST00000029673.5
Efna3
ephrin A3
chr19_-_6128208 0.691 ENSMUST00000025702.7
Snx15
sorting nexin 15
chr6_+_90619241 0.690 ENSMUST00000032177.8
Slc41a3
solute carrier family 41, member 3
chr19_+_5425121 0.633 ENSMUST00000159759.1
AI837181
expressed sequence AI837181
chr1_+_183388981 0.632 ENSMUST00000097043.5
Taf1a
TATA box binding protein (Tbp)-associated factor, RNA polymerase I, A
chr2_+_30364227 0.616 ENSMUST00000077977.7
ENSMUST00000140075.2
Fam73b

family with sequence similarity 73, member B

chr12_+_73286868 0.599 ENSMUST00000153941.1
ENSMUST00000122920.1
ENSMUST00000101313.3
Slc38a6


solute carrier family 38, member 6


chr12_+_73286779 0.599 ENSMUST00000140523.1
Slc38a6
solute carrier family 38, member 6
chr1_-_179546261 0.599 ENSMUST00000027769.5
Tfb2m
transcription factor B2, mitochondrial
chr2_+_3118335 0.583 ENSMUST00000115099.2
Fam171a1
family with sequence similarity 171, member A1
chr8_+_105701142 0.570 ENSMUST00000098444.2
Pard6a
par-6 (partitioning defective 6,) homolog alpha (C. elegans)
chr7_-_27178835 0.569 ENSMUST00000093040.6
Rab4b
RAB4B, member RAS oncogene family
chr6_+_83101565 0.563 ENSMUST00000101254.3
Ccdc142
coiled-coil domain containing 142
chr18_-_37997543 0.538 ENSMUST00000042944.7
Arap3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr12_-_87233556 0.532 ENSMUST00000021423.7
Noxred1
NADP+ dependent oxidoreductase domain containing 1
chr13_-_100108337 0.497 ENSMUST00000180822.1
BC001981
cDNA sequence BC001981
chr16_+_75592844 0.489 ENSMUST00000114249.1
ENSMUST00000046378.7
ENSMUST00000114253.1
Rbm11


RNA binding motif protein 11


chr17_-_24527830 0.469 ENSMUST00000176353.1
ENSMUST00000176237.1
Traf7

TNF receptor-associated factor 7

chr6_-_113377712 0.466 ENSMUST00000113107.1
ENSMUST00000113106.1
Tada3

transcriptional adaptor 3

chr17_-_24527925 0.462 ENSMUST00000176652.1
Traf7
TNF receptor-associated factor 7
chr9_-_117252450 0.457 ENSMUST00000111773.3
ENSMUST00000068962.7
ENSMUST00000044901.7
Rbms3


RNA binding motif, single stranded interacting protein


chr13_+_54789500 0.441 ENSMUST00000163915.1
ENSMUST00000099503.3
ENSMUST00000171859.1
Tspan17


tetraspanin 17


chr18_-_42579652 0.429 ENSMUST00000054738.3
Gpr151
G protein-coupled receptor 151
chr2_+_84678396 0.417 ENSMUST00000102645.3
Med19
mediator of RNA polymerase II transcription, subunit 19 homolog (yeast)
chr16_+_8470763 0.413 ENSMUST00000046470.9
ENSMUST00000150790.1
ENSMUST00000142899.1
Mettl22


methyltransferase like 22


chrX_+_99821021 0.407 ENSMUST00000096363.2
Tmem28
transmembrane protein 28
chr4_-_117914968 0.379 ENSMUST00000036156.5
Ipo13
importin 13
chr13_-_8870999 0.361 ENSMUST00000177404.1
ENSMUST00000176922.1
ENSMUST00000021572.4
Wdr37


WD repeat domain 37


chr1_+_74153981 0.337 ENSMUST00000027372.7
ENSMUST00000106899.2
Cxcr2

chemokine (C-X-C motif) receptor 2

chr4_-_155669171 0.334 ENSMUST00000103176.3
Mib2
mindbomb homolog 2 (Drosophila)
chr10_-_62578387 0.320 ENSMUST00000162525.1
ENSMUST00000159704.1
ENSMUST00000162759.1
ENSMUST00000065887.7
2510003E04Rik



RIKEN cDNA 2510003E04 gene



chr11_-_118415794 0.315 ENSMUST00000164927.1
Cant1
calcium activated nucleotidase 1
chr2_+_3118407 0.305 ENSMUST00000091505.4
Fam171a1
family with sequence similarity 171, member A1
chr17_+_13760502 0.275 ENSMUST00000139347.1
ENSMUST00000156591.1
ENSMUST00000170827.2
ENSMUST00000139666.1
ENSMUST00000137784.1
ENSMUST00000137708.1
ENSMUST00000150848.1
Mllt4






myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4






chr9_+_108049254 0.261 ENSMUST00000112295.2
ENSMUST00000047947.7
Gmppb

GDP-mannose pyrophosphorylase B

chr7_+_18884679 0.259 ENSMUST00000032573.6
Pglyrp1
peptidoglycan recognition protein 1
chr18_+_9958147 0.254 ENSMUST00000025137.7
Thoc1
THO complex 1
chr2_-_176149825 0.216 ENSMUST00000109049.3
ENSMUST00000179349.1
Gm2004

predicted gene 2004

chr13_-_100650981 0.214 ENSMUST00000022136.6
ENSMUST00000177848.1
Rad17

RAD17 homolog (S. pombe)

chr2_-_37703845 0.214 ENSMUST00000155237.1
Strbp
spermatid perinuclear RNA binding protein
chr1_+_85100164 0.207 ENSMUST00000097669.1
Gm10553
predicted gene 10553
chr3_+_142530329 0.200 ENSMUST00000171263.1
ENSMUST00000045097.9
Gbp7

guanylate binding protein 7

chr5_-_120777628 0.195 ENSMUST00000044833.8
Oas3
2'-5' oligoadenylate synthetase 3
chr2_+_55411790 0.191 ENSMUST00000155997.1
ENSMUST00000128307.1
Gm14033

predicted gene 14033

chr9_+_31386187 0.191 ENSMUST00000086167.5
Nfrkb
nuclear factor related to kappa B binding protein
chr1_-_133131782 0.157 ENSMUST00000180528.1
Gm26616
predicted gene, 26616
chr10_-_39899238 0.146 ENSMUST00000178563.1
AA474331
expressed sequence AA474331
chr13_+_56609516 0.138 ENSMUST00000045173.8
Tgfbi
transforming growth factor, beta induced
chr4_+_155086577 0.119 ENSMUST00000030915.4
ENSMUST00000155775.1
ENSMUST00000127457.1
Morn1


MORN repeat containing 1


chr9_+_110419750 0.095 ENSMUST00000035061.6
Ngp
neutrophilic granule protein
chr7_-_13034722 0.082 ENSMUST00000005711.4
Chmp2a
charged multivesicular body protein 2A
chr13_-_8870967 0.080 ENSMUST00000164183.2
Wdr37
WD repeat domain 37
chr17_-_56074932 0.079 ENSMUST00000019722.5
Ubxn6
UBX domain protein 6
chr12_-_70227622 0.074 ENSMUST00000071250.6
Pygl
liver glycogen phosphorylase
chr12_-_70231414 0.051 ENSMUST00000161083.1
Pygl
liver glycogen phosphorylase
chr3_-_89402650 0.042 ENSMUST00000168325.1
ENSMUST00000057431.5
Lenep

lens epithelial protein

chr2_+_3118523 0.041 ENSMUST00000062934.6
Fam171a1
family with sequence similarity 171, member A1
chr2_+_101678403 0.008 ENSMUST00000004949.7
Traf6
TNF receptor-associated factor 6
chr4_+_115563649 0.004 ENSMUST00000141033.1
ENSMUST00000030486.8
ENSMUST00000126645.1
ENSMUST00000030480.3
Cyp4a31



cytochrome P450, family 4, subfamily a, polypeptide 31



chr19_-_5610038 0.004 ENSMUST00000113641.2
Kat5
K(lysine) acetyltransferase 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.0 GO:0021649 vestibulocochlear nerve structural organization(GO:0021649) ganglion morphogenesis(GO:0061552) dorsal root ganglion morphogenesis(GO:1904835)
0.8 4.5 GO:0009405 pathogenesis(GO:0009405)
0.7 2.8 GO:0010040 response to iron(II) ion(GO:0010040) positive regulation of hydrogen peroxide metabolic process(GO:0010726) negative regulation of synaptic transmission, dopaminergic(GO:0032227) negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963) regulation of peroxidase activity(GO:2000468)
0.6 1.9 GO:0043379 rRNA export from nucleus(GO:0006407) memory T cell differentiation(GO:0043379) response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650)
0.6 1.7 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.6 1.7 GO:0090004 positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.5 8.7 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.5 1.6 GO:1904431 positive regulation of t-circle formation(GO:1904431)
0.5 2.0 GO:1903860 negative regulation of dendrite extension(GO:1903860) regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800)
0.4 2.7 GO:0097473 cellular response to light intensity(GO:0071484) cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473)
0.4 1.8 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.4 1.3 GO:1904742 regulation of telomeric DNA binding(GO:1904742)
0.4 3.7 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.3 1.1 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.3 2.3 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.2 1.3 GO:2001012 mesenchymal cell differentiation involved in kidney development(GO:0072161) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.2 1.3 GO:0071955 recycling endosome to Golgi transport(GO:0071955)
0.2 1.3 GO:0006561 proline biosynthetic process(GO:0006561)
0.2 9.8 GO:0034605 cellular response to heat(GO:0034605)
0.2 0.7 GO:0006624 vacuolar protein processing(GO:0006624)
0.2 1.8 GO:0051014 actin filament severing(GO:0051014)
0.2 0.7 GO:1905247 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) positive regulation of aspartic-type peptidase activity(GO:1905247)
0.2 0.9 GO:0032796 uropod organization(GO:0032796)
0.2 2.4 GO:0021540 corpus callosum morphogenesis(GO:0021540) corticospinal tract morphogenesis(GO:0021957)
0.2 1.4 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.1 1.0 GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.1 1.2 GO:1900113 negative regulation of histone H3-K9 trimethylation(GO:1900113)
0.1 0.9 GO:0032510 endosome to lysosome transport via multivesicular body sorting pathway(GO:0032510)
0.1 0.8 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.1 2.6 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.1 0.3 GO:0051715 cytolysis in other organism(GO:0051715)
0.1 0.3 GO:0045829 negative regulation of isotype switching(GO:0045829)
0.1 0.3 GO:0033030 negative regulation of neutrophil apoptotic process(GO:0033030)
0.1 0.1 GO:1903722 regulation of centriole elongation(GO:1903722)
0.1 0.6 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.1 0.9 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.1 0.6 GO:1904781 positive regulation of protein localization to centrosome(GO:1904781)
0.1 3.4 GO:0007528 neuromuscular junction development(GO:0007528)
0.1 0.4 GO:0098703 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.1 2.6 GO:0050919 negative chemotaxis(GO:0050919)
0.1 4.4 GO:0060113 inner ear receptor cell differentiation(GO:0060113)
0.1 1.1 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 1.3 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 1.1 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 2.9 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 1.2 GO:0014047 glutamate secretion(GO:0014047)
0.0 1.2 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 1.0 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.0 0.1 GO:0046391 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.0 0.2 GO:0060700 regulation of ribonuclease activity(GO:0060700)
0.0 2.3 GO:0046847 filopodium assembly(GO:0046847)
0.0 0.3 GO:0009191 ribonucleoside diphosphate catabolic process(GO:0009191)
0.0 0.1 GO:1901491 negative regulation of lymphangiogenesis(GO:1901491)
0.0 0.4 GO:0042921 glucocorticoid receptor signaling pathway(GO:0042921)
0.0 0.2 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.0 1.5 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 1.3 GO:0055072 iron ion homeostasis(GO:0055072)
0.0 0.9 GO:0006406 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.0 0.8 GO:0060395 SMAD protein signal transduction(GO:0060395)
0.0 1.2 GO:0097553 calcium ion transmembrane import into cytosol(GO:0097553) calcium ion import into cytosol(GO:1902656)
0.0 0.1 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.0 0.2 GO:0044406 adhesion of symbiont to host(GO:0044406)
0.0 1.7 GO:0010977 negative regulation of neuron projection development(GO:0010977)
0.0 0.6 GO:0006360 transcription from RNA polymerase I promoter(GO:0006360)
0.0 2.2 GO:0008202 steroid metabolic process(GO:0008202)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.8 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.6 1.9 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.3 1.6 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.2 3.7 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.2 1.7 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.2 3.2 GO:0032593 insulin-responsive compartment(GO:0032593)
0.2 1.3 GO:0070187 telosome(GO:0070187)
0.1 1.0 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.1 0.6 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.1 0.9 GO:0033391 chromatoid body(GO:0033391)
0.1 1.4 GO:0031209 SCAR complex(GO:0031209)
0.1 0.9 GO:0089701 U2AF(GO:0089701)
0.1 2.3 GO:0031430 M band(GO:0031430)
0.1 8.7 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 0.9 GO:0032426 stereocilium tip(GO:0032426)
0.1 3.3 GO:0045335 phagocytic vesicle(GO:0045335)
0.1 2.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.4 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.3 GO:0042629 mast cell granule(GO:0042629)
0.0 1.2 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 3.4 GO:0031594 neuromuscular junction(GO:0031594)
0.0 1.2 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.3 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 0.8 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.4 GO:0016592 mediator complex(GO:0016592)
0.0 1.9 GO:0035097 histone methyltransferase complex(GO:0035097)
0.0 2.4 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 1.2 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.9 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.6 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.2 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
0.0 1.3 GO:0005776 autophagosome(GO:0005776)
0.0 1.1 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.6 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 1.1 GO:0036126 sperm flagellum(GO:0036126)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.2 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.5 2.8 GO:0050544 arachidonic acid binding(GO:0050544)
0.4 3.0 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.4 1.1 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.3 1.3 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.3 1.6 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.3 1.9 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.3 2.4 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.3 1.2 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.3 1.1 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.2 1.2 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.2 1.7 GO:0071253 connexin binding(GO:0071253)
0.2 3.7 GO:0031402 sodium ion binding(GO:0031402)
0.2 2.6 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.2 3.7 GO:0032794 GTPase activating protein binding(GO:0032794)
0.1 0.6 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.1 1.9 GO:0015643 toxic substance binding(GO:0015643)
0.1 0.8 GO:0051185 coenzyme transporter activity(GO:0051185)
0.1 0.4 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.1 0.8 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.1 2.7 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 2.6 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1 0.3 GO:0016494 C-X-C chemokine receptor activity(GO:0016494) C-X-C chemokine binding(GO:0019958)
0.1 1.4 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.1 0.9 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 2.3 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 0.3 GO:0042834 peptidoglycan binding(GO:0042834)
0.1 0.9 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.1 0.3 GO:0004382 guanosine-diphosphatase activity(GO:0004382)
0.1 1.2 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454) histone demethylase activity (H3-K36 specific)(GO:0051864)
0.1 2.2 GO:0008146 sulfotransferase activity(GO:0008146)
0.0 1.3 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 0.1 GO:0032052 bile acid binding(GO:0032052)
0.0 2.3 GO:0030507 spectrin binding(GO:0030507)
0.0 7.9 GO:0005516 calmodulin binding(GO:0005516)
0.0 2.5 GO:0019003 GDP binding(GO:0019003)
0.0 1.1 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 1.0 GO:0008237 metallopeptidase activity(GO:0008237)
0.0 1.3 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 1.3 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 0.5 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 2.0 GO:0005080 protein kinase C binding(GO:0005080)
0.0 1.2 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 1.8 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.8 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 0.5 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 1.1 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.0 0.2 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 12.3 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.0 0.4 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.7 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 1.2 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.0 7.2 GO:0008270 zinc ion binding(GO:0008270)
0.0 0.1 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.0 0.7 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.0 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.2 2.6 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 2.7 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.1 2.8 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 3.2 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 0.7 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 1.1 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.0 2.9 PID_MET_PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 2.6 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 1.9 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 1.2 PID_BCR_5PATHWAY BCR signaling pathway
0.0 1.1 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 2.6 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.3 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 0.3 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 1.2 PID_AR_PATHWAY Coregulation of Androgen receptor activity

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.6 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.3 2.2 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.3 1.3 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.2 3.0 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.2 2.7 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.1 1.9 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1 1.8 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.1 1.2 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 3.2 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 0.7 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR
0.1 1.7 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.1 2.9 REACTOME_AMYLOIDS Genes involved in Amyloids
0.0 1.0 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 0.8 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 2.3 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 0.6 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.6 REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 0.8 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 1.1 REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0 0.8 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.0 1.8 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.2 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS Genes involved in Activation of ATR in response to replication stress
0.0 0.3 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.3 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.6 REACTOME_RNA_POL_I_RNA_POL_III_AND_MITOCHONDRIAL_TRANSCRIPTION Genes involved in RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription