Motif ID: Brca1

Z-value: 0.456


Transcription factors associated with Brca1:

Gene SymbolEntrez IDGene Name
Brca1 ENSMUSG00000017146.6 Brca1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Brca1mm10_v2_chr11_-_101551837_1015518930.114.9e-01Click!


Activity profile for motif Brca1.

activity profile for motif Brca1


Sorted Z-values histogram for motif Brca1

Sorted Z-values for motif Brca1



Network of associatons between targets according to the STRING database.



First level regulatory network of Brca1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_23248264 7.093 ENSMUST00000031709.5
Fezf1
Fez family zinc finger 1
chr11_+_44617310 2.073 ENSMUST00000081265.5
ENSMUST00000101326.3
ENSMUST00000109268.1
Ebf1


early B cell factor 1


chr1_-_75278345 1.849 ENSMUST00000039534.4
Resp18
regulated endocrine-specific protein 18
chr18_-_47333311 1.684 ENSMUST00000126684.1
ENSMUST00000156422.1
Sema6a

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

chr7_-_144939823 1.302 ENSMUST00000093962.4
Ccnd1
cyclin D1
chr11_+_97415527 1.181 ENSMUST00000121799.1
Arhgap23
Rho GTPase activating protein 23
chr16_-_16829276 1.131 ENSMUST00000023468.5
Spag6
sperm associated antigen 6
chr8_-_47990535 1.059 ENSMUST00000057561.7
Wwc2
WW, C2 and coiled-coil domain containing 2
chr11_-_106998483 0.955 ENSMUST00000124541.1
Kpna2
karyopherin (importin) alpha 2
chr10_-_33624587 0.871 ENSMUST00000160299.1
ENSMUST00000019920.6
Clvs2

clavesin 2

chr1_+_66386968 0.753 ENSMUST00000145419.1
Map2
microtubule-associated protein 2
chr6_+_14901344 0.734 ENSMUST00000115477.1
Foxp2
forkhead box P2
chr13_-_49320219 0.689 ENSMUST00000110086.1
Fgd3
FYVE, RhoGEF and PH domain containing 3
chr9_-_109082372 0.675 ENSMUST00000167504.1
Tma7
translational machinery associated 7 homolog (S. cerevisiae)
chr14_-_67715585 0.660 ENSMUST00000163100.1
ENSMUST00000132705.1
ENSMUST00000124045.1
Cdca2


cell division cycle associated 2


chr1_+_74791516 0.654 ENSMUST00000006718.8
Wnt10a
wingless related MMTV integration site 10a
chr16_+_44394771 0.631 ENSMUST00000099742.2
Wdr52
WD repeat domain 52
chr17_-_70853482 0.630 ENSMUST00000118283.1
Tgif1
TGFB-induced factor homeobox 1
chr2_-_28916668 0.627 ENSMUST00000113847.1
Barhl1
BarH-like 1 (Drosophila)
chr11_-_98625661 0.605 ENSMUST00000104933.1
Gm12355
predicted gene 12355
chr12_+_52097737 0.584 ENSMUST00000040090.9
Nubpl
nucleotide binding protein-like
chr13_-_98891036 0.579 ENSMUST00000109399.2
Tnpo1
transportin 1
chr13_-_98890974 0.576 ENSMUST00000179301.1
ENSMUST00000179271.1
Tnpo1

transportin 1

chr3_-_61365951 0.567 ENSMUST00000066298.2
B430305J03Rik
RIKEN cDNA B430305J03 gene
chr15_-_97020322 0.559 ENSMUST00000166223.1
Slc38a4
solute carrier family 38, member 4
chr2_+_174330006 0.542 ENSMUST00000109085.1
ENSMUST00000109087.1
ENSMUST00000109084.1
Gnas


GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus


chr12_-_10900296 0.532 ENSMUST00000085735.2
Pgk1-rs7
phosphoglycerate kinase-1, related sequence-7
chr17_-_65613521 0.521 ENSMUST00000024897.8
Vapa
vesicle-associated membrane protein, associated protein A
chr5_-_138187177 0.520 ENSMUST00000110937.1
ENSMUST00000139276.1
ENSMUST00000048698.7
ENSMUST00000123415.1
Taf6



TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor



chr4_+_86053887 0.515 ENSMUST00000107178.2
ENSMUST00000048885.5
ENSMUST00000141889.1
ENSMUST00000120678.1
Adamtsl1



ADAMTS-like 1



chr19_-_10203880 0.511 ENSMUST00000142241.1
ENSMUST00000116542.2
ENSMUST00000025651.5
ENSMUST00000156291.1
Fen1



flap structure specific endonuclease 1



chr1_+_192190771 0.507 ENSMUST00000078470.5
ENSMUST00000110844.1
Kcnh1

potassium voltage-gated channel, subfamily H (eag-related), member 1

chr8_-_70700070 0.506 ENSMUST00000116172.1
Gm11175
predicted gene 11175
chr3_+_87906321 0.504 ENSMUST00000005017.8
Hdgf
hepatoma-derived growth factor
chr5_-_123666682 0.494 ENSMUST00000149410.1
Clip1
CAP-GLY domain containing linker protein 1
chrX_-_101222426 0.486 ENSMUST00000120389.1
ENSMUST00000156473.1
ENSMUST00000077876.3
Snx12


sorting nexin 12


chr4_+_129058133 0.482 ENSMUST00000030584.4
ENSMUST00000168461.1
ENSMUST00000152565.1
Rnf19b


ring finger protein 19B


chr19_-_24225015 0.480 ENSMUST00000099558.4
Tjp2
tight junction protein 2
chr7_-_102100227 0.460 ENSMUST00000106937.1
Art5
ADP-ribosyltransferase 5
chr2_-_105399286 0.448 ENSMUST00000006128.6
Rcn1
reticulocalbin 1
chr17_-_47611449 0.423 ENSMUST00000024783.8
Bysl
bystin-like
chr10_-_77902467 0.418 ENSMUST00000057608.4
Lrrc3
leucine rich repeat containing 3
chr13_-_100775844 0.414 ENSMUST00000075550.3
Cenph
centromere protein H
chr3_-_138131356 0.409 ENSMUST00000029805.8
Mttp
microsomal triglyceride transfer protein
chr3_+_96172327 0.403 ENSMUST00000076372.4
Sf3b4
splicing factor 3b, subunit 4
chr6_-_120357422 0.400 ENSMUST00000032283.5
Ccdc77
coiled-coil domain containing 77
chr4_-_116708312 0.397 ENSMUST00000030453.4
Mmachc
methylmalonic aciduria cblC type, with homocystinuria
chr6_-_125191535 0.395 ENSMUST00000043848.4
Ncapd2
non-SMC condensin I complex, subunit D2
chr17_-_6655939 0.392 ENSMUST00000179554.1
Dynlt1f
dynein light chain Tctex-type 1F
chr9_-_37657189 0.392 ENSMUST00000117654.1
Tbrg1
transforming growth factor beta regulated gene 1
chr17_-_33685386 0.384 ENSMUST00000139302.1
ENSMUST00000087582.5
ENSMUST00000114385.2
Hnrnpm


heterogeneous nuclear ribonucleoprotein M


chr19_+_44562841 0.384 ENSMUST00000040455.4
Hif1an
hypoxia-inducible factor 1, alpha subunit inhibitor
chr6_-_120357342 0.382 ENSMUST00000163827.1
Ccdc77
coiled-coil domain containing 77
chr19_+_6047081 0.378 ENSMUST00000025723.8
Syvn1
synovial apoptosis inhibitor 1, synoviolin
chr11_+_59306920 0.373 ENSMUST00000000128.3
ENSMUST00000108783.3
Wnt9a

wingless-type MMTV integration site 9A

chrX_+_169685191 0.367 ENSMUST00000112104.1
ENSMUST00000112107.1
Mid1

midline 1

chr4_+_12906838 0.365 ENSMUST00000143186.1
ENSMUST00000183345.1
Triqk

triple QxxK/R motif containing

chr6_-_120357440 0.357 ENSMUST00000112703.1
Ccdc77
coiled-coil domain containing 77
chr13_+_100651328 0.355 ENSMUST00000084721.6
ENSMUST00000022135.8
Taf9
Taf9
TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor
TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr17_+_6430112 0.350 ENSMUST00000179569.1
Dynlt1b
dynein light chain Tctex-type 1B
chr5_-_25223153 0.343 ENSMUST00000066954.1
E130116L18Rik
RIKEN cDNA E130116L18 gene
chrX_+_150594420 0.333 ENSMUST00000112713.2
Pfkfb1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr7_+_101896817 0.328 ENSMUST00000143835.1
Anapc15
anaphase prompoting complex C subunit 15
chr13_-_107890059 0.320 ENSMUST00000105097.2
Zswim6
zinc finger SWIM-type containing 6
chr11_-_30198232 0.317 ENSMUST00000102838.3
Sptbn1
spectrin beta, non-erythrocytic 1
chrM_+_9452 0.313 ENSMUST00000082411.1
mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chr14_+_20674311 0.310 ENSMUST00000048657.8
Sec24c
Sec24 related gene family, member C (S. cerevisiae)
chr8_+_25017211 0.303 ENSMUST00000033961.5
Tm2d2
TM2 domain containing 2
chr7_-_64872993 0.303 ENSMUST00000094331.2
Ndnl2
necdin-like 2
chr17_+_71204647 0.290 ENSMUST00000126681.1
Lpin2
lipin 2
chr15_-_82016134 0.285 ENSMUST00000152227.1
Desi1
desumoylating isopeptidase 1
chrX_+_74309089 0.284 ENSMUST00000130581.1
Gdi1
guanosine diphosphate (GDP) dissociation inhibitor 1
chr15_+_102460076 0.282 ENSMUST00000164688.1
Prr13
proline rich 13
chr5_-_135064063 0.273 ENSMUST00000111205.1
ENSMUST00000141309.1
Wbscr22

Williams Beuren syndrome chromosome region 22

chr5_+_138187485 0.270 ENSMUST00000110934.2
Cnpy4
canopy 4 homolog (zebrafish)
chr11_-_101171302 0.270 ENSMUST00000164474.1
ENSMUST00000043397.7
Plekhh3

pleckstrin homology domain containing, family H (with MyTH4 domain) member 3

chrX_+_150589907 0.266 ENSMUST00000080884.4
Pfkfb1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr13_+_93304940 0.260 ENSMUST00000109497.1
ENSMUST00000109498.1
ENSMUST00000060490.4
ENSMUST00000109492.1
ENSMUST00000109496.1
ENSMUST00000109495.1
Homer1





homer homolog 1 (Drosophila)





chr13_-_95891905 0.256 ENSMUST00000068603.6
Iqgap2
IQ motif containing GTPase activating protein 2
chr3_+_109573907 0.255 ENSMUST00000106576.2
Vav3
vav 3 oncogene
chr7_-_133122615 0.245 ENSMUST00000167218.1
Ctbp2
C-terminal binding protein 2
chr2_-_152831665 0.244 ENSMUST00000156688.1
ENSMUST00000007803.5
Bcl2l1

BCL2-like 1

chr19_+_36083696 0.240 ENSMUST00000025714.7
Rpp30
ribonuclease P/MRP 30 subunit
chr6_-_122340499 0.240 ENSMUST00000160843.1
Phc1
polyhomeotic-like 1 (Drosophila)
chr18_+_7869707 0.235 ENSMUST00000166062.1
ENSMUST00000169010.1
Wac

WW domain containing adaptor with coiled-coil

chr2_+_167932327 0.234 ENSMUST00000029053.7
Ptpn1
protein tyrosine phosphatase, non-receptor type 1
chr5_+_136953246 0.233 ENSMUST00000111094.1
ENSMUST00000111097.1
Fis1

fission 1 (mitochondrial outer membrane) homolog (yeast)

chr7_+_51878967 0.233 ENSMUST00000051912.6
Gas2
growth arrest specific 2
chr5_+_15934685 0.230 ENSMUST00000078272.6
ENSMUST00000180204.1
ENSMUST00000167946.2
ENSMUST00000101581.3
ENSMUST00000039370.7
Cacna2d1




calcium channel, voltage-dependent, alpha2/delta subunit 1




chr2_-_25224653 0.228 ENSMUST00000043584.4
Tubb4b
tubulin, beta 4B class IVB
chr9_+_59589288 0.222 ENSMUST00000121266.1
ENSMUST00000118164.1
Celf6

CUGBP, Elav-like family member 6

chr19_+_45560569 0.215 ENSMUST00000047057.7
Dpcd
deleted in primary ciliary dyskinesia
chr7_-_102099932 0.204 ENSMUST00000106934.1
Art5
ADP-ribosyltransferase 5
chr7_-_44375006 0.198 ENSMUST00000107933.1
1700008O03Rik
RIKEN cDNA 1700008O03 gene
chr12_+_103388656 0.198 ENSMUST00000101094.2
ENSMUST00000021620.6
Otub2

OTU domain, ubiquitin aldehyde binding 2

chr16_+_22009471 0.197 ENSMUST00000023561.7
Senp2
SUMO/sentrin specific peptidase 2
chr17_+_7945653 0.195 ENSMUST00000097423.2
Rsph3a
radial spoke 3A homolog (Chlamydomonas)
chr19_-_32466575 0.192 ENSMUST00000078034.3
Rpl9-ps6
ribosomal protein L9, pseudogene 6
chr19_+_46152505 0.185 ENSMUST00000026254.7
Gbf1
golgi-specific brefeldin A-resistance factor 1
chr9_+_108392820 0.185 ENSMUST00000035234.4
1700102P08Rik
RIKEN cDNA 1700102P08 gene
chr19_-_7295394 0.183 ENSMUST00000025921.8
Mark2
MAP/microtubule affinity-regulating kinase 2
chr17_+_35841668 0.183 ENSMUST00000174124.1
Mdc1
mediator of DNA damage checkpoint 1
chr7_-_30072801 0.181 ENSMUST00000183115.1
ENSMUST00000182919.1
ENSMUST00000183190.1
ENSMUST00000080834.8
Zfp82



zinc finger protein 82



chr17_-_15498263 0.180 ENSMUST00000014913.9
Psmb1
proteasome (prosome, macropain) subunit, beta type 1
chr11_+_93886157 0.179 ENSMUST00000063718.4
ENSMUST00000107854.2
Mbtd1

mbt domain containing 1

chr12_-_69159109 0.179 ENSMUST00000037023.8
Rps29
ribosomal protein S29
chr12_-_108894116 0.178 ENSMUST00000109848.3
Wars
tryptophanyl-tRNA synthetase
chr2_-_34870921 0.176 ENSMUST00000028225.5
Psmd5
proteasome (prosome, macropain) 26S subunit, non-ATPase, 5
chr18_+_36952621 0.175 ENSMUST00000115661.2
Pcdha2
protocadherin alpha 2
chrM_+_8600 0.174 ENSMUST00000082409.1
mt-Co3
mitochondrially encoded cytochrome c oxidase III
chr13_+_24943144 0.163 ENSMUST00000021773.5
Gpld1
glycosylphosphatidylinositol specific phospholipase D1
chr11_+_6291660 0.161 ENSMUST00000101554.2
ENSMUST00000093350.3
Ogdh

oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)

chr15_-_27681498 0.160 ENSMUST00000100739.3
Fam105a
family with sequence similarity 105, member A
chr2_-_91183017 0.159 ENSMUST00000066420.5
Madd
MAP-kinase activating death domain
chr11_-_102230127 0.155 ENSMUST00000107150.1
ENSMUST00000156337.1
ENSMUST00000107151.2
ENSMUST00000107152.2
Hdac5



histone deacetylase 5



chr4_+_10874498 0.155 ENSMUST00000080517.7
ENSMUST00000101504.2
2610301B20Rik

RIKEN cDNA 2610301B20 gene

chr4_+_148000722 0.148 ENSMUST00000103230.4
Nppa
natriuretic peptide type A
chr6_-_122340525 0.145 ENSMUST00000112600.2
Phc1
polyhomeotic-like 1 (Drosophila)
chr9_+_112234257 0.142 ENSMUST00000149308.3
ENSMUST00000144424.2
ENSMUST00000139552.2
2900079G21Rik


RIKEN cDNA 2900079G21 gene


chr11_+_82035569 0.136 ENSMUST00000000193.5
Ccl2
chemokine (C-C motif) ligand 2
chr14_-_54864055 0.131 ENSMUST00000142283.2
Homez
homeodomain leucine zipper-encoding gene
chr18_-_15063560 0.130 ENSMUST00000168989.1
Kctd1
potassium channel tetramerisation domain containing 1
chr5_-_115158169 0.130 ENSMUST00000053271.5
ENSMUST00000112121.1
Mlec

malectin

chr5_+_146833106 0.130 ENSMUST00000075453.2
ENSMUST00000099272.2
Rpl21

ribosomal protein L21

chr12_+_87266696 0.130 ENSMUST00000021425.6
Ahsa1
AHA1, activator of heat shock protein ATPase 1
chr12_-_99393010 0.129 ENSMUST00000177451.1
Foxn3
forkhead box N3
chr11_+_97703394 0.125 ENSMUST00000103147.4
Psmb3
proteasome (prosome, macropain) subunit, beta type 3
chr11_-_69920581 0.124 ENSMUST00000108610.1
Eif5a
eukaryotic translation initiation factor 5A
chrM_+_7759 0.121 ENSMUST00000082407.1
ENSMUST00000082408.1
mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chrX_-_64276937 0.118 ENSMUST00000114679.1
ENSMUST00000069926.7
Slitrk4

SLIT and NTRK-like family, member 4

chr7_+_129591859 0.117 ENSMUST00000084519.5
Wdr11
WD repeat domain 11
chr11_-_102230091 0.115 ENSMUST00000008999.5
Hdac5
histone deacetylase 5
chr12_-_24493656 0.115 ENSMUST00000073088.2
Gm16372
predicted pseudogene 16372
chr4_-_98817537 0.110 ENSMUST00000102790.3
Kank4
KN motif and ankyrin repeat domains 4
chr14_-_52305056 0.110 ENSMUST00000174853.1
ENSMUST00000022767.9
Mettl3

methyltransferase like 3

chr7_-_113369326 0.109 ENSMUST00000047091.7
ENSMUST00000119278.1
Btbd10

BTB (POZ) domain containing 10

chr3_-_95882031 0.107 ENSMUST00000161994.1
Gm129
predicted gene 129
chr5_+_72914264 0.106 ENSMUST00000144843.1
Slain2
SLAIN motif family, member 2
chr11_+_6291607 0.102 ENSMUST00000003461.8
Ogdh
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr1_+_182124737 0.097 ENSMUST00000111018.1
ENSMUST00000027792.5
Srp9

signal recognition particle 9

chr2_-_9883993 0.095 ENSMUST00000114915.2
9230102O04Rik
RIKEN cDNA 9230102O04 gene
chr13_+_100651607 0.094 ENSMUST00000167256.1
Taf9
TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr19_-_10525201 0.092 ENSMUST00000025570.6
Sdhaf2
succinate dehydrogenase complex assembly factor 2
chr17_-_6948283 0.086 ENSMUST00000024572.9
Rsph3b
radial spoke 3B homolog (Chlamydomonas)
chr8_-_95853501 0.085 ENSMUST00000040481.3
Slc38a7
solute carrier family 38, member 7
chr3_+_87930256 0.078 ENSMUST00000055984.6
Isg20l2
interferon stimulated exonuclease gene 20-like 2
chr15_+_10952332 0.074 ENSMUST00000022853.8
ENSMUST00000110523.1
C1qtnf3

C1q and tumor necrosis factor related protein 3

chr17_+_33909481 0.073 ENSMUST00000173626.1
ENSMUST00000174541.1
Daxx

Fas death domain-associated protein

chr10_-_128923948 0.071 ENSMUST00000131271.1
Bloc1s1
biogenesis of lysosome-related organelles complex-1, subunit 1
chr11_-_11890368 0.069 ENSMUST00000155690.1
Ddc
dopa decarboxylase
chr17_+_35841491 0.067 ENSMUST00000082337.6
Mdc1
mediator of DNA damage checkpoint 1
chr13_+_55714624 0.064 ENSMUST00000021959.9
Txndc15
thioredoxin domain containing 15
chr11_-_104550392 0.062 ENSMUST00000106962.2
Cdc27
cell division cycle 27
chr1_-_46854046 0.061 ENSMUST00000027131.4
Slc39a10
solute carrier family 39 (zinc transporter), member 10
chr2_-_91182848 0.058 ENSMUST00000111370.2
ENSMUST00000111376.1
ENSMUST00000099723.2
Madd


MAP-kinase activating death domain


chr5_+_147077050 0.050 ENSMUST00000050970.3
Polr1d
polymerase (RNA) I polypeptide D
chr6_+_100833606 0.049 ENSMUST00000063854.4
Ppp4r2
protein phosphatase 4, regulatory subunit 2
chr12_+_4082596 0.047 ENSMUST00000049584.5
Dnajc27
DnaJ (Hsp40) homolog, subfamily C, member 27
chr12_+_108894272 0.044 ENSMUST00000167816.1
ENSMUST00000047115.7
Wdr25

WD repeat domain 25

chr5_+_72914554 0.044 ENSMUST00000143829.1
Slain2
SLAIN motif family, member 2
chr3_-_100489324 0.042 ENSMUST00000061455.8
Fam46c
family with sequence similarity 46, member C
chr11_-_104550460 0.041 ENSMUST00000106961.1
ENSMUST00000093923.2
Cdc27

cell division cycle 27

chr4_+_43631935 0.038 ENSMUST00000030191.8
Npr2
natriuretic peptide receptor 2
chr3_-_90433603 0.035 ENSMUST00000029542.5
ENSMUST00000071488.3
Ints3

integrator complex subunit 3

chr4_+_43632185 0.032 ENSMUST00000107874.2
Npr2
natriuretic peptide receptor 2
chr7_+_5080214 0.031 ENSMUST00000098845.3
ENSMUST00000146317.1
ENSMUST00000153169.1
ENSMUST00000045277.6
Epn1



epsin 1



chr9_+_82829806 0.030 ENSMUST00000113245.2
ENSMUST00000034783.4
Irak1bp1

interleukin-1 receptor-associated kinase 1 binding protein 1

chr7_-_126503408 0.026 ENSMUST00000040202.8
Atxn2l
ataxin 2-like
chr5_-_21701332 0.026 ENSMUST00000115217.1
ENSMUST00000060899.8
Napepld

N-acyl phosphatidylethanolamine phospholipase D

chr7_+_123377982 0.019 ENSMUST00000033025.5
Lcmt1
leucine carboxyl methyltransferase 1
chr17_+_8165501 0.017 ENSMUST00000097419.3
ENSMUST00000024636.8
Fgfr1op

Fgfr1 oncogene partner

chr8_+_26977336 0.012 ENSMUST00000154256.1
ENSMUST00000127097.1
Zfp703

zinc finger protein 703

chr5_+_146832890 0.010 ENSMUST00000035983.5
Rpl21
ribosomal protein L21
chr10_-_128923439 0.010 ENSMUST00000153731.1
ENSMUST00000026405.3
Bloc1s1

biogenesis of lysosome-related organelles complex-1, subunit 1

chr18_+_7869342 0.006 ENSMUST00000092112.4
ENSMUST00000172018.1
ENSMUST00000168446.1
Wac


WW domain containing adaptor with coiled-coil


chr7_+_24370255 0.005 ENSMUST00000171904.1
Kcnn4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr8_+_12915879 0.005 ENSMUST00000110876.2
ENSMUST00000110879.2
Mcf2l

mcf.2 transforming sequence-like

chr2_-_155582656 0.005 ENSMUST00000126322.1
Gss
glutathione synthetase
chr11_-_50325599 0.001 ENSMUST00000179865.1
ENSMUST00000020637.8
Canx

calnexin

chr12_-_84617326 0.000 ENSMUST00000021666.4
Abcd4
ATP-binding cassette, sub-family D (ALD), member 4
chr10_-_13388830 0.000 ENSMUST00000079698.5
Phactr2
phosphatase and actin regulator 2
chr7_+_16816299 0.000 ENSMUST00000108495.2
Strn4
striatin, calmodulin binding protein 4
chr10_+_69925766 0.000 ENSMUST00000182269.1
ENSMUST00000183261.1
ENSMUST00000183074.1
Ank3


ankyrin 3, epithelial



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 7.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.2 1.3 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.2 0.5 GO:2000642 negative regulation of early endosome to late endosome transport(GO:2000642)
0.2 0.5 GO:1903011 negative regulation of bone development(GO:1903011)
0.2 1.1 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.1 0.4 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.1 0.5 GO:0044861 protein transport into plasma membrane raft(GO:0044861)
0.1 0.5 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.1 1.2 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.1 0.5 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
0.1 0.5 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.1 0.5 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.1 0.4 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.1 0.4 GO:0042364 water-soluble vitamin biosynthetic process(GO:0042364)
0.1 0.2 GO:1904578 response to thapsigargin(GO:1904578) cellular response to thapsigargin(GO:1904579)
0.1 0.6 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1 0.2 GO:1902277 negative regulation of pancreatic amylase secretion(GO:1902277)
0.1 1.7 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.1 1.0 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 0.2 GO:0070973 COPI-coated vesicle budding(GO:0035964) protein localization to endoplasmic reticulum exit site(GO:0070973)
0.1 0.7 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.1 0.2 GO:0046898 response to cycloheximide(GO:0046898)
0.1 0.2 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.1 0.7 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.1 0.2 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.1 0.2 GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202) negative regulation of PERK-mediated unfolded protein response(GO:1903898)
0.1 0.2 GO:0086048 membrane depolarization during bundle of His cell action potential(GO:0086048)
0.1 0.2 GO:0002430 complement receptor mediated signaling pathway(GO:0002430) GPI anchor release(GO:0006507)
0.1 0.4 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.4 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.0 0.4 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.0 0.1 GO:0060372 regulation of atrial cardiac muscle cell membrane repolarization(GO:0060372)
0.0 0.2 GO:0071894 histone H2B conserved C-terminal lysine ubiquitination(GO:0071894)
0.0 0.3 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.0 0.3 GO:0061034 olfactory bulb mitral cell layer development(GO:0061034)
0.0 0.5 GO:0072643 interferon-gamma secretion(GO:0072643)
0.0 0.1 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.0 0.6 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.1 GO:1904690 regulation of cap-independent translational initiation(GO:1903677) positive regulation of cap-independent translational initiation(GO:1903679) regulation of cytoplasmic translational initiation(GO:1904688) positive regulation of cytoplasmic translational initiation(GO:1904690)
0.0 0.2 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 0.3 GO:0090315 negative regulation of protein targeting to membrane(GO:0090315)
0.0 0.1 GO:2000427 eosinophil chemotaxis(GO:0048245) T cell extravasation(GO:0072683) positive regulation of apoptotic cell clearance(GO:2000427)
0.0 0.3 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.0 0.4 GO:0051382 kinetochore assembly(GO:0051382)
0.0 0.7 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.0 0.6 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 0.3 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.1 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.0 0.3 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.2 GO:0021678 third ventricle development(GO:0021678)
0.0 0.1 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.0 0.2 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.0 0.2 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.0 0.3 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.0 0.2 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.1 GO:0071638 negative regulation of monocyte chemotactic protein-1 production(GO:0071638)
0.0 0.3 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 0.1 GO:1903936 response to diamide(GO:0072737) cellular response to diamide(GO:0072738) cellular response to sodium arsenite(GO:1903936)
0.0 0.8 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.0 0.1 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.0 0.6 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.4 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.4 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236)
0.0 0.4 GO:0035115 embryonic forelimb morphogenesis(GO:0035115)
0.0 0.4 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.0 0.4 GO:0000132 establishment of mitotic spindle orientation(GO:0000132)
0.0 0.1 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.0 0.9 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.0 0.1 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.0 0.3 GO:2001222 regulation of neuron migration(GO:2001222)
0.0 0.3 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.2 0.6 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.2 0.5 GO:0044194 cytolytic granule(GO:0044194)
0.1 0.4 GO:0000799 nuclear condensin complex(GO:0000799)
0.1 0.8 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 0.4 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.1 0.4 GO:0000125 PCAF complex(GO:0000125)
0.1 0.5 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.1 0.3 GO:0032437 cuticular plate(GO:0032437)
0.0 0.4 GO:0042382 paraspeckles(GO:0042382)
0.0 0.1 GO:0044299 C-fiber(GO:0044299)
0.0 0.2 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 0.2 GO:0097443 sorting endosome(GO:0097443)
0.0 0.4 GO:0001739 sex chromatin(GO:0001739)
0.0 0.5 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.3 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.0 GO:0098888 extrinsic component of presynaptic membrane(GO:0098888)
0.0 0.3 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 1.5 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.2 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.2 GO:0097427 microtubule bundle(GO:0097427)
0.0 0.2 GO:0045298 tubulin complex(GO:0045298)
0.0 0.4 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.2 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 1.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.1 GO:0036396 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.0 0.3 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.1 GO:0042629 mast cell granule(GO:0042629)
0.0 0.5 GO:0005921 gap junction(GO:0005921)
0.0 0.4 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.5 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.5 GO:0030673 axolemma(GO:0030673)
0.0 1.3 GO:0005643 nuclear pore(GO:0005643)
0.0 0.1 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.0 0.2 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.4 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.3 GO:0005839 proteasome core complex(GO:0005839)
0.0 0.2 GO:0097470 ribbon synapse(GO:0097470)
0.0 0.0 GO:0030289 protein phosphatase 4 complex(GO:0030289)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0003953 NAD+ nucleosidase activity(GO:0003953)
0.2 2.5 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.1 0.5 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.1 0.3 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 0.8 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 0.5 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.1 0.6 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.1 0.5 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.1 1.7 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 0.4 GO:0043515 kinetochore binding(GO:0043515)
0.1 0.3 GO:0005093 Rab GDP-dissociation inhibitor activity(GO:0005093)
0.1 2.1 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 0.2 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.1 0.4 GO:0071532 ankyrin repeat binding(GO:0071532)
0.1 0.2 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.1 0.4 GO:0031419 cobalamin binding(GO:0031419)
0.1 0.3 GO:0034602 oxoglutarate dehydrogenase (NAD+) activity(GO:0034602)
0.1 0.5 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 1.2 GO:0070064 proline-rich region binding(GO:0070064)
0.0 1.1 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 7.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.3 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.0 0.4 GO:1990405 protein antigen binding(GO:1990405)
0.0 0.1 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.0 0.2 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.5 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.2 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.0 0.2 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.0 0.1 GO:0015182 L-asparagine transmembrane transporter activity(GO:0015182)
0.0 0.1 GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422)
0.0 0.2 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.4 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 1.0 GO:0005109 frizzled binding(GO:0005109)
0.0 0.3 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 0.3 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.4 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0 0.2 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 0.1 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 0.1 GO:0036468 aromatic-L-amino-acid decarboxylase activity(GO:0004058) L-dopa decarboxylase activity(GO:0036468)
0.0 0.4 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.3 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.1 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.1 GO:0005047 signal recognition particle binding(GO:0005047) 7S RNA binding(GO:0008312)
0.0 0.6 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.3 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.0 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.8 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.4 PID_MYC_PATHWAY C-MYC pathway
0.0 1.5 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.2 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.5 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.8 PID_LKB1_PATHWAY LKB1 signaling events
0.0 0.3 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 1.7 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.1 1.2 REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.1 0.5 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 1.3 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.4 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 2.1 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.3 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.0 0.6 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 1.0 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.2 REACTOME_REGULATION_OF_IFNG_SIGNALING Genes involved in Regulation of IFNG signaling
0.0 0.4 REACTOME_REGULATION_OF_HYPOXIA_INDUCIBLE_FACTOR_HIF_BY_OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.0 1.6 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.2 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.3 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.2 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.6 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.2 REACTOME_COPI_MEDIATED_TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.8 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.6 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.2 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.1 REACTOME_N_GLYCAN_TRIMMING_IN_THE_ER_AND_CALNEXIN_CALRETICULIN_CYCLE Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.0 0.3 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.5 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.2 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.4 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.5 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.0 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes