Motif ID: Glis3

Z-value: 0.581


Transcription factors associated with Glis3:

Gene SymbolEntrez IDGene Name
Glis3 ENSMUSG00000052942.7 Glis3
Glis3 ENSMUSG00000091294.1 Glis3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Glis3mm10_v2_chr19_-_28680077_286801220.143.8e-01Click!


Activity profile for motif Glis3.

activity profile for motif Glis3


Sorted Z-values histogram for motif Glis3

Sorted Z-values for motif Glis3



Network of associatons between targets according to the STRING database.



First level regulatory network of Glis3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_144893077 1.918 ENSMUST00000154208.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr4_+_144892813 1.898 ENSMUST00000105744.1
ENSMUST00000171001.1
Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr4_+_144893127 1.862 ENSMUST00000142808.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr6_+_17463749 1.393 ENSMUST00000115443.1
Met
met proto-oncogene
chr7_-_142657466 1.148 ENSMUST00000097936.2
ENSMUST00000000033.5
Igf2

insulin-like growth factor 2

chr6_+_17463826 1.027 ENSMUST00000140070.1
Met
met proto-oncogene
chr6_+_17463927 0.954 ENSMUST00000115442.1
Met
met proto-oncogene
chr7_-_49636847 0.894 ENSMUST00000032717.6
Dbx1
developing brain homeobox 1
chr13_-_40730416 0.850 ENSMUST00000021787.5
Tfap2a
transcription factor AP-2, alpha
chr7_-_142899985 0.832 ENSMUST00000000219.3
Th
tyrosine hydroxylase
chr11_+_101468164 0.829 ENSMUST00000001347.6
Rnd2
Rho family GTPase 2
chr4_-_134018829 0.757 ENSMUST00000051674.2
Lin28a
lin-28 homolog A (C. elegans)
chrM_+_9452 0.702 ENSMUST00000082411.1
mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chr11_-_102296618 0.680 ENSMUST00000107132.2
ENSMUST00000073234.2
Atxn7l3

ataxin 7-like 3

chr14_+_54640952 0.625 ENSMUST00000169818.2
Gm17606
predicted gene, 17606
chr13_+_44730726 0.621 ENSMUST00000173704.1
ENSMUST00000044608.7
ENSMUST00000173367.1
Jarid2


jumonji, AT rich interactive domain 2


chr10_-_105574435 0.564 ENSMUST00000061506.8
Tmtc2
transmembrane and tetratricopeptide repeat containing 2
chr13_+_38345716 0.562 ENSMUST00000171970.1
Bmp6
bone morphogenetic protein 6
chr4_+_118428078 0.555 ENSMUST00000006557.6
ENSMUST00000167636.1
ENSMUST00000102673.4
Elovl1


elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1


chr10_+_61175206 0.526 ENSMUST00000079235.5
Tbata
thymus, brain and testes associated
chr1_-_64121456 0.525 ENSMUST00000142009.1
ENSMUST00000114086.1
Klf7

Kruppel-like factor 7 (ubiquitous)

chr8_-_87959560 0.515 ENSMUST00000109655.2
Zfp423
zinc finger protein 423
chrM_+_8600 0.513 ENSMUST00000082409.1
mt-Co3
mitochondrially encoded cytochrome c oxidase III
chr13_-_29984219 0.500 ENSMUST00000146092.1
E2f3
E2F transcription factor 3
chr1_-_64121389 0.488 ENSMUST00000055001.3
Klf7
Kruppel-like factor 7 (ubiquitous)
chr3_-_66981279 0.484 ENSMUST00000162098.2
Shox2
short stature homeobox 2
chr10_-_68278713 0.466 ENSMUST00000020106.7
Arid5b
AT rich interactive domain 5B (MRF1-like)
chr7_+_126781483 0.454 ENSMUST00000172352.1
ENSMUST00000094037.4
Tbx6

T-box 6

chr11_+_77216180 0.436 ENSMUST00000037912.5
ENSMUST00000156488.1
Ssh2

slingshot homolog 2 (Drosophila)

chr3_+_52268337 0.429 ENSMUST00000053764.5
Foxo1
forkhead box O1
chr9_-_108305941 0.429 ENSMUST00000044725.7
Tcta
T cell leukemia translocation altered gene
chr3_+_103914560 0.426 ENSMUST00000106806.1
Rsbn1
rosbin, round spermatid basic protein 1
chr11_-_69801716 0.421 ENSMUST00000011285.4
ENSMUST00000102585.1
Fgf11

fibroblast growth factor 11

chr17_-_23745829 0.421 ENSMUST00000046525.8
Kremen2
kringle containing transmembrane protein 2
chr13_+_119428888 0.414 ENSMUST00000026520.7
Paip1
polyadenylate binding protein-interacting protein 1
chr17_+_80944611 0.408 ENSMUST00000025092.4
Tmem178
transmembrane protein 178
chr16_+_20733104 0.407 ENSMUST00000115423.1
ENSMUST00000007171.6
Chrd

chordin

chr14_+_45219993 0.399 ENSMUST00000146150.1
Gpr137c
G protein-coupled receptor 137C
chr13_+_119428583 0.394 ENSMUST00000109203.2
Paip1
polyadenylate binding protein-interacting protein 1
chr14_+_62292475 0.371 ENSMUST00000166879.1
Rnaseh2b
ribonuclease H2, subunit B
chr15_+_102406143 0.370 ENSMUST00000170884.1
ENSMUST00000165924.1
ENSMUST00000163709.1
ENSMUST00000001326.6
Sp1



trans-acting transcription factor 1



chr14_+_55561060 0.361 ENSMUST00000117701.1
Dcaf11
DDB1 and CUL4 associated factor 11
chrX_-_111697069 0.359 ENSMUST00000113422.2
ENSMUST00000038472.5
Hdx

highly divergent homeobox

chr11_-_115536181 0.352 ENSMUST00000118155.1
ENSMUST00000153892.1
Sumo2

SMT3 suppressor of mif two 3 homolog 2 (yeast)

chr7_+_90442729 0.344 ENSMUST00000061767.4
ENSMUST00000107206.1
Crebzf

CREB/ATF bZIP transcription factor

chr10_-_7663245 0.336 ENSMUST00000163085.1
ENSMUST00000159917.1
Pcmt1

protein-L-isoaspartate (D-aspartate) O-methyltransferase 1

chr17_+_56326045 0.327 ENSMUST00000139679.1
ENSMUST00000025036.4
ENSMUST00000086835.5
Kdm4b


lysine (K)-specific demethylase 4B


chr19_+_8941865 0.327 ENSMUST00000096240.2
Mta2
metastasis-associated gene family, member 2
chrX_-_94123359 0.327 ENSMUST00000137853.1
ENSMUST00000088102.5
ENSMUST00000113927.1
Zfx


zinc finger protein X-linked


chr11_+_3289880 0.323 ENSMUST00000110043.1
ENSMUST00000094471.3
Patz1

POZ (BTB) and AT hook containing zinc finger 1

chr16_+_44173271 0.321 ENSMUST00000088356.4
ENSMUST00000169582.1
Gm608

predicted gene 608

chr7_+_127485221 0.320 ENSMUST00000048896.6
Fbrs
fibrosin
chrX_-_38564519 0.293 ENSMUST00000016681.8
Cul4b
cullin 4B
chrX_+_101254528 0.289 ENSMUST00000062000.4
Foxo4
forkhead box O4
chr11_-_115535804 0.289 ENSMUST00000117589.1
ENSMUST00000121185.1
Sumo2

SMT3 suppressor of mif two 3 homolog 2 (yeast)

chr11_-_85139939 0.283 ENSMUST00000108075.2
Usp32
ubiquitin specific peptidase 32
chrX_+_71364901 0.280 ENSMUST00000132837.1
Mtmr1
myotubularin related protein 1
chr2_-_119477613 0.277 ENSMUST00000110808.1
ENSMUST00000049920.7
Ino80

INO80 homolog (S. cerevisiae)

chrX_-_23365044 0.276 ENSMUST00000115313.1
Klhl13
kelch-like 13
chr6_-_83572429 0.272 ENSMUST00000068054.7
Stambp
STAM binding protein
chr18_-_47368446 0.263 ENSMUST00000076043.6
ENSMUST00000135790.1
Sema6a

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

chr14_+_55560480 0.262 ENSMUST00000121622.1
ENSMUST00000143431.1
ENSMUST00000150481.1
Dcaf11


DDB1 and CUL4 associated factor 11


chr5_-_72974702 0.259 ENSMUST00000043711.8
Gm10135
predicted gene 10135
chr14_+_55560904 0.258 ENSMUST00000072530.4
ENSMUST00000128490.1
Dcaf11

DDB1 and CUL4 associated factor 11

chr11_-_52000432 0.250 ENSMUST00000020657.6
Ube2b
ubiquitin-conjugating enzyme E2B
chr2_-_114052804 0.249 ENSMUST00000090269.6
Actc1
actin, alpha, cardiac muscle 1
chr7_-_75308373 0.241 ENSMUST00000085164.5
Sv2b
synaptic vesicle glycoprotein 2 b
chr11_+_5861886 0.241 ENSMUST00000102923.3
Aebp1
AE binding protein 1
chr8_+_70863127 0.235 ENSMUST00000050921.2
A230052G05Rik
RIKEN cDNA A230052G05 gene
chrX_+_71364745 0.224 ENSMUST00000114601.1
ENSMUST00000146213.1
ENSMUST00000015358.1
Mtmr1


myotubularin related protein 1


chr3_-_142881942 0.214 ENSMUST00000043812.8
Pkn2
protein kinase N2
chr9_+_108306205 0.209 ENSMUST00000007959.8
Rhoa
ras homolog gene family, member A
chr2_-_73892619 0.203 ENSMUST00000112007.1
ENSMUST00000112016.2
Atf2

activating transcription factor 2

chr3_+_66981352 0.202 ENSMUST00000162036.1
Rsrc1
arginine/serine-rich coiled-coil 1
chr11_-_52000748 0.199 ENSMUST00000109086.1
Ube2b
ubiquitin-conjugating enzyme E2B
chr7_-_4778141 0.197 ENSMUST00000094892.5
Il11
interleukin 11
chrX_-_94123087 0.196 ENSMUST00000113925.1
Zfx
zinc finger protein X-linked
chr3_+_121426495 0.195 ENSMUST00000029773.8
Cnn3
calponin 3, acidic
chr18_+_34777008 0.185 ENSMUST00000043775.7
Kdm3b
KDM3B lysine (K)-specific demethylase 3B
chr2_-_73892588 0.184 ENSMUST00000154456.1
ENSMUST00000090802.4
ENSMUST00000055833.5
Atf2


activating transcription factor 2


chr7_+_16875302 0.176 ENSMUST00000108493.1
Dact3
dapper homolog 3, antagonist of beta-catenin (xenopus)
chr10_+_127739516 0.166 ENSMUST00000054287.7
Zbtb39
zinc finger and BTB domain containing 39
chr2_-_73892530 0.164 ENSMUST00000136958.1
ENSMUST00000112010.2
ENSMUST00000128531.1
ENSMUST00000112017.1
Atf2



activating transcription factor 2



chr2_+_32646586 0.159 ENSMUST00000009705.7
ENSMUST00000167841.1
Eng

endoglin

chr7_+_90130227 0.159 ENSMUST00000049537.7
Picalm
phosphatidylinositol binding clathrin assembly protein
chr11_+_116030304 0.153 ENSMUST00000021116.5
ENSMUST00000106452.1
Unk

unkempt homolog (Drosophila)

chr2_-_152831112 0.152 ENSMUST00000128172.1
Bcl2l1
BCL2-like 1
chr4_+_137993445 0.152 ENSMUST00000105831.2
ENSMUST00000084214.5
Eif4g3

eukaryotic translation initiation factor 4 gamma, 3

chr15_+_102407144 0.151 ENSMUST00000169619.1
Sp1
trans-acting transcription factor 1
chr3_+_107595031 0.146 ENSMUST00000014747.1
Alx3
aristaless-like homeobox 3
chr2_-_18998126 0.146 ENSMUST00000006912.5
Pip4k2a
phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
chr10_-_127211528 0.144 ENSMUST00000013970.7
Pip4k2c
phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
chr6_+_95117740 0.134 ENSMUST00000032107.7
ENSMUST00000119582.1
Kbtbd8

kelch repeat and BTB (POZ) domain containing 8

chr2_-_156111954 0.129 ENSMUST00000142960.2
ENSMUST00000136296.2
ENSMUST00000059647.5
ENSMUST00000109604.2
ENSMUST00000138068.1
ENSMUST00000128499.1
Cpne1

Rbm12



copine I

RNA binding motif protein 12



chr19_+_46305682 0.124 ENSMUST00000111881.2
Nfkb2
nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
chr13_-_107022027 0.122 ENSMUST00000117539.1
ENSMUST00000122233.1
ENSMUST00000022204.9
ENSMUST00000159772.1
Kif2a



kinesin family member 2A



chr12_+_102949450 0.116 ENSMUST00000179002.1
Unc79
unc-79 homolog (C. elegans)
chrX_-_136868537 0.113 ENSMUST00000058814.6
Rab9b
RAB9B, member RAS oncogene family
chr9_+_31280525 0.112 ENSMUST00000117389.1
Prdm10
PR domain containing 10
chr15_-_85581809 0.110 ENSMUST00000023015.7
Wnt7b
wingless-related MMTV integration site 7B
chr11_+_98795495 0.108 ENSMUST00000037915.2
Msl1
male-specific lethal 1 homolog (Drosophila)
chr3_+_89245952 0.107 ENSMUST00000040888.5
Krtcap2
keratinocyte associated protein 2
chrX_-_94542037 0.105 ENSMUST00000026142.7
Maged1
melanoma antigen, family D, 1
chr7_+_25282179 0.103 ENSMUST00000163320.1
ENSMUST00000005578.6
Cic

capicua homolog (Drosophila)

chr6_+_88198656 0.102 ENSMUST00000015197.7
Gata2
GATA binding protein 2
chr5_+_104459450 0.100 ENSMUST00000086831.3
Pkd2
polycystic kidney disease 2
chr8_-_88362154 0.092 ENSMUST00000034085.7
Brd7
bromodomain containing 7
chr11_-_100619576 0.092 ENSMUST00000155152.1
Dnajc7
DnaJ (Hsp40) homolog, subfamily C, member 7
chr2_-_156111863 0.091 ENSMUST00000154889.1
ENSMUST00000079312.3
ENSMUST00000153634.1
ENSMUST00000133921.1
ENSMUST00000184265.1
ENSMUST00000109607.3
ENSMUST00000109608.2
ENSMUST00000131377.1
ENSMUST00000183518.1
Cpne1






Rbm12
RP23-220D12.12
copine I






RNA binding motif protein 12
RNA-binding protein 12
chr5_-_24527276 0.084 ENSMUST00000088311.4
Gbx1
gastrulation brain homeobox 1
chr2_-_29253001 0.083 ENSMUST00000071201.4
Ntng2
netrin G2
chr2_-_152830615 0.082 ENSMUST00000146380.1
ENSMUST00000134902.1
ENSMUST00000134357.1
ENSMUST00000109820.3
Bcl2l1



BCL2-like 1



chr11_-_102317860 0.080 ENSMUST00000107117.2
Ubtf
upstream binding transcription factor, RNA polymerase I
chr3_+_89246397 0.076 ENSMUST00000168900.1
Krtcap2
keratinocyte associated protein 2
chr6_+_145934113 0.069 ENSMUST00000032383.7
Sspn
sarcospan
chr7_-_46795881 0.064 ENSMUST00000107653.1
ENSMUST00000107654.1
ENSMUST00000014562.7
ENSMUST00000152759.1
Hps5



Hermansky-Pudlak syndrome 5 homolog (human)



chr11_+_69632927 0.063 ENSMUST00000018909.3
Fxr2
fragile X mental retardation, autosomal homolog 2
chr14_+_25607797 0.062 ENSMUST00000160229.1
Zmiz1
zinc finger, MIZ-type containing 1
chr11_-_97187872 0.056 ENSMUST00000001479.4
Kpnb1
karyopherin (importin) beta 1
chr16_+_20673517 0.054 ENSMUST00000115460.1
Eif4g1
eukaryotic translation initiation factor 4, gamma 1
chr7_+_25282784 0.052 ENSMUST00000165239.1
Cic
capicua homolog (Drosophila)
chr5_-_122989260 0.048 ENSMUST00000118027.1
Kdm2b
lysine (K)-specific demethylase 2B
chr7_-_46795661 0.043 ENSMUST00000123725.1
Hps5
Hermansky-Pudlak syndrome 5 homolog (human)
chrX_-_7574120 0.042 ENSMUST00000045924.7
ENSMUST00000115742.2
ENSMUST00000150787.1
Ppp1r3f


protein phosphatase 1, regulatory (inhibitor) subunit 3F


chr10_+_93641041 0.042 ENSMUST00000020204.4
Ntn4
netrin 4
chr2_-_152831665 0.040 ENSMUST00000156688.1
ENSMUST00000007803.5
Bcl2l1

BCL2-like 1

chr3_-_94582716 0.027 ENSMUST00000029783.9
Snx27
sorting nexin family member 27
chr11_-_96065350 0.025 ENSMUST00000100528.4
Ube2z
ubiquitin-conjugating enzyme E2Z (putative)
chr11_+_97663366 0.018 ENSMUST00000044730.5
Mllt6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chrX_-_142966709 0.013 ENSMUST00000041317.2
Ammecr1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chrX_-_101419788 0.007 ENSMUST00000117901.1
ENSMUST00000120201.1
ENSMUST00000117637.1
ENSMUST00000134005.1
ENSMUST00000121520.1
Zmym3




zinc finger, MYM-type 3




chr1_-_168431896 0.002 ENSMUST00000176540.1
Pbx1
pre B cell leukemia homeobox 1
chr11_+_77982710 0.001 ENSMUST00000108360.1
ENSMUST00000049167.7
Phf12

PHD finger protein 12


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 5.7 GO:0042572 retinol metabolic process(GO:0042572)
0.5 3.4 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.3 0.9 GO:0070172 oculomotor nerve development(GO:0021557) positive regulation of tooth mineralization(GO:0070172)
0.2 0.8 GO:0042414 epinephrine metabolic process(GO:0042414)
0.2 0.6 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.1 0.4 GO:0010845 positive regulation of reciprocal meiotic recombination(GO:0010845)
0.1 1.1 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.1 0.2 GO:1990869 response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869)
0.1 0.6 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.1 0.6 GO:0032346 positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349)
0.1 0.4 GO:0072675 osteoclast fusion(GO:0072675)
0.1 0.8 GO:0010587 miRNA catabolic process(GO:0010587)
0.1 0.4 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.1 0.8 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 0.5 GO:0070814 hydrogen sulfide biosynthetic process(GO:0070814)
0.1 0.3 GO:0046898 response to cycloheximide(GO:0046898)
0.1 0.5 GO:0014043 negative regulation of neuron maturation(GO:0014043)
0.1 0.1 GO:0072053 renal inner medulla development(GO:0072053) renal outer medulla development(GO:0072054)
0.1 0.2 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.1 0.2 GO:1905072 detection of oxygen(GO:0003032) positive regulation of vascular smooth muscle cell differentiation(GO:1905065) cardiac jelly development(GO:1905072)
0.1 0.5 GO:0060613 fat pad development(GO:0060613)
0.1 0.6 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.2 GO:0030240 skeletal muscle thin filament assembly(GO:0030240)
0.0 0.9 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.0 0.5 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742) embryonic skeletal joint morphogenesis(GO:0060272) regulation of branching morphogenesis of a nerve(GO:2000172)
0.0 0.3 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.0 0.6 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.0 0.6 GO:0070914 UV-damage excision repair(GO:0070914)
0.0 0.4 GO:0071455 response to hyperoxia(GO:0055093) cellular response to hyperoxia(GO:0071455)
0.0 0.2 GO:0060903 positive regulation of meiosis I(GO:0060903)
0.0 0.3 GO:1900113 negative regulation of histone H3-K9 trimethylation(GO:1900113)
0.0 0.2 GO:1905247 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) negative regulation of metalloendopeptidase activity(GO:1904684) positive regulation of aspartic-type peptidase activity(GO:1905247)
0.0 0.2 GO:0072718 response to cisplatin(GO:0072718)
0.0 0.1 GO:0019230 proprioception(GO:0019230)
0.0 0.6 GO:0033235 positive regulation of protein sumoylation(GO:0033235)
0.0 0.4 GO:0045671 negative regulation of osteoclast differentiation(GO:0045671)
0.0 0.1 GO:0051599 response to hydrostatic pressure(GO:0051599)
0.0 0.7 GO:0016578 histone deubiquitination(GO:0016578)
0.0 0.5 GO:0060746 parental behavior(GO:0060746)
0.0 0.7 GO:0071384 cellular response to corticosteroid stimulus(GO:0071384) cellular response to glucocorticoid stimulus(GO:0071385)
0.0 0.3 GO:0046498 S-adenosylhomocysteine metabolic process(GO:0046498)
0.0 0.5 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.2 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.0 0.4 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.0 0.3 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.0 0.1 GO:0051305 chromosome movement towards spindle pole(GO:0051305)
0.0 0.2 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 0.1 GO:0014029 neural crest formation(GO:0014029)
0.0 0.5 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 0.1 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 0.3 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.0 0.1 GO:0035115 embryonic forelimb morphogenesis(GO:0035115)
0.0 0.2 GO:0018195 peptidyl-arginine modification(GO:0018195)
0.0 0.2 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.0 0.4 GO:0010591 regulation of lamellipodium assembly(GO:0010591)
0.0 0.0 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.0 0.1 GO:0006362 transcription elongation from RNA polymerase I promoter(GO:0006362)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1 0.4 GO:0033503 HULC complex(GO:0033503)
0.1 0.4 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.1 0.2 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.0 3.5 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.3 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0 0.7 GO:0000124 SAGA complex(GO:0000124)
0.0 0.9 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.1 GO:0031084 BLOC-2 complex(GO:0031084)
0.0 0.3 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.3 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.6 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.1 GO:0072487 MSL complex(GO:0072487)
0.0 0.3 GO:0031011 Ino80 complex(GO:0031011)
0.0 0.1 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.3 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.6 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.7 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.7 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.6 GO:0016605 PML body(GO:0016605)
0.0 0.8 GO:0010494 cytoplasmic stress granule(GO:0010494)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.4 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.8 5.7 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.2 0.8 GO:0035240 dopamine binding(GO:0035240)
0.1 0.8 GO:0008494 translation activator activity(GO:0008494)
0.1 0.5 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.1 0.8 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.1 0.4 GO:0045545 syndecan binding(GO:0045545)
0.1 0.3 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.1 0.6 GO:0070700 BMP receptor binding(GO:0070700)
0.1 0.4 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.1 0.6 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.1 0.6 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.6 GO:0031386 protein tag(GO:0031386)
0.0 1.1 GO:0043539 insulin-like growth factor receptor binding(GO:0005159) protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.3 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.2 GO:0005534 galactose binding(GO:0005534)
0.0 0.1 GO:1902379 chemoattractant activity involved in axon guidance(GO:1902379)
0.0 0.5 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.7 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.1 GO:0048763 calcium-induced calcium release activity(GO:0048763)
0.0 0.8 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.7 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.2 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.5 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.2 GO:0051022 Rho GDP-dissociation inhibitor binding(GO:0051022)
0.0 0.9 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.1 GO:0001165 RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165)
0.0 0.2 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.2 GO:1990715 mRNA CDS binding(GO:1990715)
0.0 0.2 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.2 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.3 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.4 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.2 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 0.7 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.0 GO:2001069 glycogen binding(GO:2001069)
0.0 0.3 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.2 GO:0004697 protein kinase C activity(GO:0004697)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 6.2 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 3.3 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.7 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 1.7 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 0.2 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 1.1 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.0 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.5 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.9 PID_CASPASE_PATHWAY Caspase cascade in apoptosis

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.5 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.1 0.8 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 1.1 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.5 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.6 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.8 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 0.6 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.3 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.4 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.5 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.3 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions