Motif ID: Hoxa6

Z-value: 0.751


Transcription factors associated with Hoxa6:

Gene SymbolEntrez IDGene Name
Hoxa6 ENSMUSG00000043219.8 Hoxa6



Activity profile for motif Hoxa6.

activity profile for motif Hoxa6


Sorted Z-values histogram for motif Hoxa6

Sorted Z-values for motif Hoxa6



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa6

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_71528657 22.238 ENSMUST00000126400.1
Dlx1
distal-less homeobox 1
chr8_-_46294592 10.727 ENSMUST00000058636.7
Helt
helt bHLH transcription factor
chr19_-_59170978 10.238 ENSMUST00000172821.2
Vax1
ventral anterior homeobox containing gene 1
chr1_-_163313661 8.138 ENSMUST00000174397.1
ENSMUST00000075805.6
ENSMUST00000027878.7
Prrx1


paired related homeobox 1


chr14_-_118052235 7.867 ENSMUST00000022725.2
Dct
dopachrome tautomerase
chr6_+_15185203 6.151 ENSMUST00000154448.1
Foxp2
forkhead box P2
chr2_-_36104060 4.770 ENSMUST00000112961.3
ENSMUST00000112966.3
Lhx6

LIM homeobox protein 6

chr15_-_8710734 4.701 ENSMUST00000005493.7
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr2_+_70474923 4.140 ENSMUST00000100043.2
Sp5
trans-acting transcription factor 5
chr5_-_123141067 4.128 ENSMUST00000162697.1
ENSMUST00000160321.1
ENSMUST00000159637.1
AI480526


expressed sequence AI480526


chr13_-_103764502 3.541 ENSMUST00000074616.5
Srek1
splicing regulatory glutamine/lysine-rich protein 1
chr16_+_42907563 3.444 ENSMUST00000151244.1
ENSMUST00000114694.2
Zbtb20

zinc finger and BTB domain containing 20

chr14_-_48665098 3.408 ENSMUST00000118578.1
Otx2
orthodenticle homolog 2 (Drosophila)
chr15_-_8710409 3.261 ENSMUST00000157065.1
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr10_-_42583628 3.167 ENSMUST00000019938.4
Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr2_+_20737306 3.166 ENSMUST00000114606.1
ENSMUST00000114608.1
Etl4

enhancer trap locus 4

chr4_+_11579647 3.127 ENSMUST00000180239.1
Fsbp
fibrinogen silencer binding protein
chr4_-_14621805 2.545 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chr14_-_122451109 2.524 ENSMUST00000081580.2
Gm5089
predicted gene 5089
chr8_-_84773381 2.493 ENSMUST00000109764.1
Nfix
nuclear factor I/X
chr10_+_97479470 2.362 ENSMUST00000105287.3
Dcn
decorin
chr13_-_83729544 2.325 ENSMUST00000181705.1
Gm26803
predicted gene, 26803
chr17_-_58991343 2.029 ENSMUST00000025064.7
2610034M16Rik
RIKEN cDNA 2610034M16 gene
chr3_+_84952146 1.912 ENSMUST00000029727.7
Fbxw7
F-box and WD-40 domain protein 7
chr19_+_55894508 1.851 ENSMUST00000142291.1
Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr1_+_19103022 1.843 ENSMUST00000037294.7
Tfap2d
transcription factor AP-2, delta
chr13_-_97747373 1.838 ENSMUST00000123535.1
5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr2_-_58052832 1.779 ENSMUST00000090940.5
Ermn
ermin, ERM-like protein
chr2_+_116067933 1.758 ENSMUST00000156095.1
G630016G05Rik
RIKEN cDNA G630016G05 gene
chr17_+_75178797 1.758 ENSMUST00000112516.1
ENSMUST00000135447.1
Ltbp1

latent transforming growth factor beta binding protein 1

chr1_+_137928100 1.724 ENSMUST00000054333.2
A130050O07Rik
RIKEN cDNA A130050O07 gene
chr5_+_42067960 1.691 ENSMUST00000087332.4
Gm16223
predicted gene 16223
chr1_-_165934900 1.676 ENSMUST00000069609.5
ENSMUST00000111427.2
ENSMUST00000111426.4
Pou2f1


POU domain, class 2, transcription factor 1


chr17_+_75178911 1.600 ENSMUST00000112514.1
Ltbp1
latent transforming growth factor beta binding protein 1
chr13_-_84064772 1.587 ENSMUST00000182477.1
Gm17750
predicted gene, 17750
chr5_+_149678224 1.528 ENSMUST00000100404.3
B3galtl
beta 1,3-galactosyltransferase-like
chr10_-_13388753 1.437 ENSMUST00000105546.1
Phactr2
phosphatase and actin regulator 2
chr10_+_88091070 1.427 ENSMUST00000048621.7
Pmch
pro-melanin-concentrating hormone
chr2_-_116067391 1.412 ENSMUST00000140185.1
2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr1_+_104768510 1.397 ENSMUST00000062528.8
Cdh20
cadherin 20
chr2_+_79707780 1.358 ENSMUST00000090760.2
ENSMUST00000040863.4
ENSMUST00000111780.2
Ppp1r1c


protein phosphatase 1, regulatory (inhibitor) subunit 1C


chr10_-_13388830 1.338 ENSMUST00000079698.5
Phactr2
phosphatase and actin regulator 2
chr2_+_26591423 1.315 ENSMUST00000152988.2
ENSMUST00000149789.1
Egfl7

EGF-like domain 7

chr6_-_138422898 1.314 ENSMUST00000161450.1
ENSMUST00000163024.1
ENSMUST00000162185.1
Lmo3


LIM domain only 3


chr4_-_14621669 1.307 ENSMUST00000143105.1
Slc26a7
solute carrier family 26, member 7
chr4_-_14621494 1.298 ENSMUST00000149633.1
Slc26a7
solute carrier family 26, member 7
chr2_-_33942111 1.276 ENSMUST00000130988.1
ENSMUST00000127936.1
ENSMUST00000134271.1
Gm13403


predicted gene 13403


chr1_-_87394721 1.247 ENSMUST00000113212.3
Kcnj13
potassium inwardly-rectifying channel, subfamily J, member 13
chr7_-_109170308 1.237 ENSMUST00000036992.7
Lmo1
LIM domain only 1
chr7_-_116038734 1.233 ENSMUST00000166877.1
Sox6
SRY-box containing gene 6
chr12_-_54986363 1.225 ENSMUST00000173433.1
ENSMUST00000173803.1
Baz1a
Gm20403
bromodomain adjacent to zinc finger domain 1A
predicted gene 20403
chr14_-_46390501 1.216 ENSMUST00000100676.2
Bmp4
bone morphogenetic protein 4
chr2_+_132847719 1.207 ENSMUST00000124836.1
ENSMUST00000154160.1
Crls1

cardiolipin synthase 1

chr19_+_55895508 1.193 ENSMUST00000111646.1
Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr3_+_41563356 1.187 ENSMUST00000163764.1
Phf17
PHD finger protein 17
chr5_+_111581422 1.184 ENSMUST00000064930.3
C130026L21Rik
RIKEN cDNA C130026L21 gene
chr2_-_168767029 1.129 ENSMUST00000075044.3
Sall4
sal-like 4 (Drosophila)
chr8_-_105568298 1.121 ENSMUST00000005849.5
Agrp
agouti related protein
chr14_-_48662740 1.111 ENSMUST00000122009.1
Otx2
orthodenticle homolog 2 (Drosophila)
chrM_+_7005 1.098 ENSMUST00000082405.1
mt-Co2
mitochondrially encoded cytochrome c oxidase II
chr1_-_166002591 1.095 ENSMUST00000111429.4
ENSMUST00000176800.1
Pou2f1

POU domain, class 2, transcription factor 1

chr7_-_37773555 1.045 ENSMUST00000176534.1
Zfp536
zinc finger protein 536
chr14_-_46390576 1.045 ENSMUST00000074077.5
Bmp4
bone morphogenetic protein 4
chr16_-_95459245 0.967 ENSMUST00000176345.1
ENSMUST00000121809.2
ENSMUST00000118113.1
ENSMUST00000122199.1
Erg



avian erythroblastosis virus E-26 (v-ets) oncogene related



chr9_-_42399915 0.966 ENSMUST00000042190.7
Tecta
tectorin alpha
chr9_-_32541589 0.960 ENSMUST00000016231.7
Fli1
Friend leukemia integration 1
chr9_-_42399709 0.954 ENSMUST00000160940.1
Tecta
tectorin alpha
chr12_-_54986328 0.938 ENSMUST00000038926.6
Baz1a
bromodomain adjacent to zinc finger domain 1A
chrX_-_59166080 0.923 ENSMUST00000119306.1
Fgf13
fibroblast growth factor 13
chr9_+_120929216 0.905 ENSMUST00000130466.1
Ctnnb1
catenin (cadherin associated protein), beta 1
chr5_+_89027959 0.887 ENSMUST00000130041.1
Slc4a4
solute carrier family 4 (anion exchanger), member 4
chr13_-_53473074 0.873 ENSMUST00000021922.8
Msx2
msh homeobox 2
chr1_-_166002613 0.872 ENSMUST00000177358.1
ENSMUST00000160908.1
ENSMUST00000027850.8
ENSMUST00000160260.2
Pou2f1



POU domain, class 2, transcription factor 1



chr6_-_138426735 0.856 ENSMUST00000162932.1
Lmo3
LIM domain only 3
chr10_-_40302186 0.855 ENSMUST00000099945.4
Amd1
S-adenosylmethionine decarboxylase 1
chr13_+_63014934 0.853 ENSMUST00000091560.4
2010111I01Rik
RIKEN cDNA 2010111I01 gene
chr13_-_18382041 0.831 ENSMUST00000139064.2
ENSMUST00000175703.2
Pou6f2

POU domain, class 6, transcription factor 2

chr5_+_66968416 0.829 ENSMUST00000038188.7
Limch1
LIM and calponin homology domains 1
chr2_-_63184253 0.818 ENSMUST00000075052.3
ENSMUST00000112454.1
Kcnh7

potassium voltage-gated channel, subfamily H (eag-related), member 7

chr4_-_110292719 0.802 ENSMUST00000106601.1
Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr9_-_60141220 0.788 ENSMUST00000034829.5
Thsd4
thrombospondin, type I, domain containing 4
chr11_-_33203588 0.764 ENSMUST00000037746.6
Tlx3
T cell leukemia, homeobox 3
chr15_-_79285502 0.759 ENSMUST00000165408.1
Baiap2l2
BAI1-associated protein 2-like 2
chr3_+_130180882 0.754 ENSMUST00000106353.1
ENSMUST00000080335.4
Col25a1

collagen, type XXV, alpha 1

chr4_-_42168603 0.747 ENSMUST00000098121.3
Gm13305
predicted gene 13305
chr11_+_102604370 0.732 ENSMUST00000057893.5
Fzd2
frizzled homolog 2 (Drosophila)
chr2_-_170194033 0.731 ENSMUST00000180625.1
Gm17619
predicted gene, 17619
chr3_+_68572245 0.728 ENSMUST00000170788.2
Schip1
schwannomin interacting protein 1
chr4_-_82885148 0.716 ENSMUST00000048430.3
Cer1
cerberus 1 homolog (Xenopus laevis)
chr16_+_43247278 0.706 ENSMUST00000114691.1
ENSMUST00000079441.6
Zbtb20

zinc finger and BTB domain containing 20

chr18_+_69593361 0.705 ENSMUST00000114978.2
ENSMUST00000114977.1
Tcf4

transcription factor 4

chr10_-_20725023 0.698 ENSMUST00000020165.7
Pde7b
phosphodiesterase 7B
chr10_-_53638269 0.690 ENSMUST00000164393.1
Fam184a
family with sequence similarity 184, member A
chr5_+_13399309 0.684 ENSMUST00000030714.7
ENSMUST00000141968.1
Sema3a

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A

chr16_-_88056176 0.682 ENSMUST00000072256.5
ENSMUST00000023652.8
ENSMUST00000114137.1
Grik1


glutamate receptor, ionotropic, kainate 1


chr6_+_17491216 0.674 ENSMUST00000080469.5
Met
met proto-oncogene
chr4_-_92191749 0.670 ENSMUST00000123179.1
Gm12666
predicted gene 12666
chr12_-_73047179 0.641 ENSMUST00000050029.7
Six1
sine oculis-related homeobox 1
chr19_+_26749726 0.631 ENSMUST00000175842.1
Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr9_+_46998931 0.627 ENSMUST00000178065.1
Gm4791
predicted gene 4791
chr17_-_51810866 0.615 ENSMUST00000176669.1
Satb1
special AT-rich sequence binding protein 1
chr12_-_56613270 0.613 ENSMUST00000072631.5
Nkx2-9
NK2 homeobox 9
chr3_+_118430299 0.599 ENSMUST00000180774.1
Gm26871
predicted gene, 26871
chr4_+_5724304 0.598 ENSMUST00000108380.1
Fam110b
family with sequence similarity 110, member B
chr12_-_34528844 0.588 ENSMUST00000110819.2
Hdac9
histone deacetylase 9
chr1_+_177445660 0.585 ENSMUST00000077225.6
Zbtb18
zinc finger and BTB domain containing 18
chr5_+_89028035 0.572 ENSMUST00000113216.2
ENSMUST00000134303.1
Slc4a4

solute carrier family 4 (anion exchanger), member 4

chr11_+_78826575 0.543 ENSMUST00000147875.2
ENSMUST00000141321.1
Lyrm9

LYR motif containing 9

chr7_-_115824699 0.529 ENSMUST00000169129.1
Sox6
SRY-box containing gene 6
chr19_-_19001099 0.517 ENSMUST00000040153.8
ENSMUST00000112828.1
Rorb

RAR-related orphan receptor beta

chr13_-_91388079 0.510 ENSMUST00000181054.1
A830009L08Rik
RIKEN cDNA A830009L08 gene
chr1_+_187997821 0.506 ENSMUST00000027906.6
Esrrg
estrogen-related receptor gamma
chr10_+_42860348 0.490 ENSMUST00000063063.7
Scml4
sex comb on midleg-like 4 (Drosophila)
chr10_+_90576252 0.483 ENSMUST00000182427.1
ENSMUST00000182053.1
ENSMUST00000182113.1
Anks1b


ankyrin repeat and sterile alpha motif domain containing 1B


chr16_+_43503607 0.481 ENSMUST00000126100.1
ENSMUST00000123047.1
ENSMUST00000156981.1
Zbtb20


zinc finger and BTB domain containing 20


chr5_-_123140135 0.468 ENSMUST00000160099.1
AI480526
expressed sequence AI480526
chr4_-_21685782 0.467 ENSMUST00000076206.4
Prdm13
PR domain containing 13
chr7_+_49910112 0.464 ENSMUST00000056442.5
Slc6a5
solute carrier family 6 (neurotransmitter transporter, glycine), member 5
chr1_+_187997835 0.462 ENSMUST00000110938.1
Esrrg
estrogen-related receptor gamma
chr2_-_63184170 0.458 ENSMUST00000112452.1
Kcnh7
potassium voltage-gated channel, subfamily H (eag-related), member 7
chr10_+_42860648 0.454 ENSMUST00000105495.1
Scml4
sex comb on midleg-like 4 (Drosophila)
chr10_+_87859062 0.446 ENSMUST00000095360.4
Igf1
insulin-like growth factor 1
chr1_+_177444653 0.445 ENSMUST00000094276.3
Zbtb18
zinc finger and BTB domain containing 18
chr13_-_105054895 0.442 ENSMUST00000063551.5
Rgs7bp
regulator of G-protein signalling 7 binding protein
chr3_-_59220150 0.435 ENSMUST00000170388.1
P2ry12
purinergic receptor P2Y, G-protein coupled 12
chr1_+_19212054 0.419 ENSMUST00000064976.4
Tfap2b
transcription factor AP-2 beta
chr5_+_117841839 0.411 ENSMUST00000142742.2
Nos1
nitric oxide synthase 1, neuronal
chr9_-_40346290 0.394 ENSMUST00000121357.1
Gramd1b
GRAM domain containing 1B
chr6_-_138421379 0.388 ENSMUST00000163065.1
Lmo3
LIM domain only 3
chr12_+_21417872 0.376 ENSMUST00000180671.1
Gm4419
predicted gene 4419
chr8_-_67974567 0.371 ENSMUST00000098696.3
ENSMUST00000038959.9
ENSMUST00000093469.4
Psd3


pleckstrin and Sec7 domain containing 3


chr8_-_67818284 0.363 ENSMUST00000120071.1
Psd3
pleckstrin and Sec7 domain containing 3
chr10_-_35711891 0.355 ENSMUST00000080898.2
Amd2
S-adenosylmethionine decarboxylase 2
chrM_+_2743 0.349 ENSMUST00000082392.1
mt-Nd1
mitochondrially encoded NADH dehydrogenase 1
chr5_+_115235836 0.335 ENSMUST00000081497.6
Pop5
processing of precursor 5, ribonuclease P/MRP family (S. cerevisiae)
chr16_-_64786321 0.319 ENSMUST00000052588.4
Zfp654
zinc finger protein 654
chr15_+_18818895 0.317 ENSMUST00000166873.2
Cdh10
cadherin 10
chr13_+_83732438 0.308 ENSMUST00000182701.1
C130071C03Rik
RIKEN cDNA C130071C03 gene
chr16_+_43235856 0.296 ENSMUST00000146708.1
Zbtb20
zinc finger and BTB domain containing 20
chr7_-_84679346 0.295 ENSMUST00000069537.2
ENSMUST00000178385.1
Zfand6

zinc finger, AN1-type domain 6

chr3_-_138131356 0.292 ENSMUST00000029805.8
Mttp
microsomal triglyceride transfer protein
chr11_-_42182924 0.291 ENSMUST00000020707.5
ENSMUST00000132971.1
Gabra1

gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1

chr10_+_42860776 0.289 ENSMUST00000105494.1
Scml4
sex comb on midleg-like 4 (Drosophila)
chr2_+_9882622 0.279 ENSMUST00000114919.1
4930412O13Rik
RIKEN cDNA 4930412O13 gene
chr18_+_42394539 0.275 ENSMUST00000025374.3
Pou4f3
POU domain, class 4, transcription factor 3
chr8_-_67818218 0.266 ENSMUST00000059374.4
Psd3
pleckstrin and Sec7 domain containing 3
chr9_-_119825456 0.265 ENSMUST00000070617.7
Scn11a
sodium channel, voltage-gated, type XI, alpha
chr9_-_71163224 0.263 ENSMUST00000074465.2
Aqp9
aquaporin 9
chr14_+_28511344 0.261 ENSMUST00000112272.1
Wnt5a
wingless-related MMTV integration site 5A
chr14_-_48667508 0.260 ENSMUST00000144465.1
ENSMUST00000133479.1
ENSMUST00000119070.1
ENSMUST00000152018.1
Otx2



orthodenticle homolog 2 (Drosophila)



chr7_-_37772868 0.251 ENSMUST00000176205.1
Zfp536
zinc finger protein 536
chr16_-_56024628 0.251 ENSMUST00000119981.1
ENSMUST00000096021.3
Pcnp

PEST proteolytic signal containing nuclear protein

chr4_-_82850721 0.247 ENSMUST00000139401.1
Zdhhc21
zinc finger, DHHC domain containing 21
chr10_+_87859255 0.245 ENSMUST00000105300.2
Igf1
insulin-like growth factor 1
chr2_-_72986716 0.245 ENSMUST00000112062.1
Gm11084
predicted gene 11084
chr2_-_168767136 0.242 ENSMUST00000029061.5
ENSMUST00000103074.1
Sall4

sal-like 4 (Drosophila)

chr13_-_97747399 0.237 ENSMUST00000144993.1
5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr19_-_53371766 0.236 ENSMUST00000086887.1
Gm10197
predicted gene 10197
chr5_+_13398688 0.230 ENSMUST00000125629.1
Sema3a
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr13_+_80883403 0.228 ENSMUST00000099356.2
Arrdc3
arrestin domain containing 3
chr7_-_73541738 0.225 ENSMUST00000169922.2
Chd2
chromodomain helicase DNA binding protein 2
chr5_+_66968559 0.214 ENSMUST00000127184.1
Limch1
LIM and calponin homology domains 1
chr10_+_99263224 0.203 ENSMUST00000020118.4
Dusp6
dual specificity phosphatase 6
chr2_+_72297895 0.199 ENSMUST00000144111.1
Zak
sterile alpha motif and leucine zipper containing kinase AZK
chr10_+_90576570 0.195 ENSMUST00000182786.1
ENSMUST00000182600.1
Anks1b

ankyrin repeat and sterile alpha motif domain containing 1B

chr5_+_34989473 0.193 ENSMUST00000114284.1
ENSMUST00000114285.1
Rgs12

regulator of G-protein signaling 12

chr18_+_54990280 0.155 ENSMUST00000181538.1
Gm4221
predicted gene 4221
chr9_+_118478344 0.152 ENSMUST00000035020.8
Eomes
eomesodermin homolog (Xenopus laevis)
chr7_+_131542867 0.149 ENSMUST00000046093.5
Hmx3
H6 homeobox 3
chr5_-_62765618 0.127 ENSMUST00000159470.1
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr19_+_26748268 0.122 ENSMUST00000175791.1
ENSMUST00000176698.1
ENSMUST00000177252.1
ENSMUST00000176475.1
ENSMUST00000112637.2
Smarca2




SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2




chr10_+_90576678 0.120 ENSMUST00000182284.1
Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr2_-_33086366 0.112 ENSMUST00000049618.2
Garnl3
GTPase activating RANGAP domain-like 3
chr9_-_112187898 0.112 ENSMUST00000178410.1
ENSMUST00000172380.3
Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr11_+_94044331 0.106 ENSMUST00000024979.8
Spag9
sperm associated antigen 9
chr4_-_97584605 0.105 ENSMUST00000107067.1
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr4_-_97584612 0.102 ENSMUST00000107068.2
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr10_-_116549101 0.100 ENSMUST00000164088.1
Cnot2
CCR4-NOT transcription complex, subunit 2
chr2_-_168206875 0.098 ENSMUST00000057793.4
Adnp
activity-dependent neuroprotective protein
chr11_-_37235882 0.094 ENSMUST00000102801.1
Tenm2
teneurin transmembrane protein 2
chr11_+_94044241 0.094 ENSMUST00000103168.3
Spag9
sperm associated antigen 9
chr16_+_19028232 0.091 ENSMUST00000074116.4
Gm10088
predicted gene 10088
chr5_-_142817387 0.085 ENSMUST00000036253.6
Tnrc18
trinucleotide repeat containing 18
chr4_-_120815703 0.066 ENSMUST00000120779.1
Nfyc
nuclear transcription factor-Y gamma
chr4_+_107968332 0.043 ENSMUST00000106713.3
Slc1a7
solute carrier family 1 (glutamate transporter), member 7
chr10_+_90576708 0.037 ENSMUST00000182430.1
ENSMUST00000182960.1
ENSMUST00000182045.1
ENSMUST00000182083.1
Anks1b



ankyrin repeat and sterile alpha motif domain containing 1B



chr9_+_61372359 0.034 ENSMUST00000178113.1
ENSMUST00000159386.1
Tle3

transducin-like enhancer of split 3, homolog of Drosophila E(spl)

chr8_-_47352348 0.031 ENSMUST00000110367.2
Stox2
storkhead box 2
chr3_-_8964037 0.018 ENSMUST00000091354.5
ENSMUST00000094381.4
Tpd52

tumor protein D52

chr2_-_168207063 0.003 ENSMUST00000088001.5
Adnp
activity-dependent neuroprotective protein
chr11_+_94044194 0.002 ENSMUST00000092777.4
ENSMUST00000075695.6
Spag9

sperm associated antigen 9


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
7.4 22.2 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
2.0 8.0 GO:0043490 malate-aspartate shuttle(GO:0043490)
1.3 7.9 GO:0006570 tyrosine metabolic process(GO:0006570)
1.3 10.2 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406)
1.2 4.8 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.9 14.1 GO:0097154 GABAergic neuron differentiation(GO:0097154)
0.9 8.1 GO:0048664 neuron fate determination(GO:0048664)
0.8 2.3 GO:0048389 BMP signaling pathway involved in heart induction(GO:0003130) endodermal-mesodermal cell signaling(GO:0003133) endodermal-mesodermal cell signaling involved in heart induction(GO:0003134) negative regulation of immature T cell proliferation in thymus(GO:0033088) cloaca development(GO:0035844) intermediate mesoderm development(GO:0048389) regulation of transcription from RNA polymerase II promoter involved in kidney development(GO:0060994) pattern specification involved in mesonephros development(GO:0061227) regulation of hepatocyte differentiation(GO:0070366) anterior/posterior pattern specification involved in kidney development(GO:0072098) negative regulation of glomerular mesangial cell proliferation(GO:0072125) metanephric S-shaped body morphogenesis(GO:0072284) negative regulation of glomerulus development(GO:0090194) regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462) cardiac jelly development(GO:1905072) negative regulation of cell proliferation involved in heart morphogenesis(GO:2000137)
0.7 5.1 GO:0019532 oxalate transport(GO:0019532)
0.6 4.3 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.5 1.4 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.5 0.9 GO:0036023 limb joint morphogenesis(GO:0036022) embryonic skeletal limb joint morphogenesis(GO:0036023)
0.4 3.0 GO:0010908 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334)
0.4 1.2 GO:0006597 spermine biosynthetic process(GO:0006597)
0.4 1.9 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.4 1.1 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.3 2.4 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.3 0.9 GO:0035880 embryonic nail plate morphogenesis(GO:0035880) positive regulation of catagen(GO:0051795) frontal suture morphogenesis(GO:0060364)
0.3 1.7 GO:0060385 axonogenesis involved in innervation(GO:0060385)
0.3 3.2 GO:0002118 aggressive behavior(GO:0002118)
0.2 2.4 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.2 0.7 GO:1900108 negative regulation of nodal signaling pathway(GO:1900108)
0.2 0.7 GO:1900141 regulation of oligodendrocyte apoptotic process(GO:1900141) negative regulation of oligodendrocyte apoptotic process(GO:1900142)
0.2 1.0 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223)
0.2 1.0 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199) positive regulation of blood vessel remodeling(GO:2000504)
0.2 4.1 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.2 1.8 GO:0021780 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.2 1.1 GO:0008343 adult feeding behavior(GO:0008343)
0.2 0.5 GO:0036233 glycine import(GO:0036233)
0.2 3.4 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.2 1.2 GO:0032049 cardiolipin biosynthetic process(GO:0032049)
0.1 1.5 GO:0015701 bicarbonate transport(GO:0015701)
0.1 0.4 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.1 0.4 GO:0097274 urea homeostasis(GO:0097274)
0.1 0.4 GO:0099548 drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738) trans-synaptic signaling by nitric oxide(GO:0099548)
0.1 0.9 GO:0098909 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200) regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909)
0.1 0.7 GO:0032229 positive regulation of gamma-aminobutyric acid secretion(GO:0014054) negative regulation of synaptic transmission, GABAergic(GO:0032229)
0.1 0.8 GO:0048251 elastic fiber assembly(GO:0048251)
0.1 4.4 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 0.7 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.1 0.5 GO:0046549 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.1 1.3 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 1.4 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.1 0.2 GO:0090327 negative regulation of locomotion involved in locomotory behavior(GO:0090327)
0.1 0.3 GO:0021562 vestibulocochlear nerve development(GO:0021562)
0.1 0.2 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.1 0.7 GO:0042118 endothelial cell activation(GO:0042118)
0.1 0.6 GO:0034983 peptidyl-lysine deacetylation(GO:0034983) regulation of skeletal muscle fiber development(GO:0048742)
0.1 0.3 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.1 1.0 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0 0.7 GO:0001553 luteinization(GO:0001553)
0.0 2.6 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.0 1.2 GO:0010107 potassium ion import(GO:0010107)
0.0 0.8 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0 0.3 GO:0009249 protein lipoylation(GO:0009249)
0.0 2.2 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 1.3 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 0.2 GO:0038032 termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.0 1.0 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.5 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.0 0.3 GO:0015791 polyol transport(GO:0015791) bile acid secretion(GO:0032782)
0.0 0.5 GO:0002087 regulation of respiratory gaseous exchange by neurological system process(GO:0002087)
0.0 1.4 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.0 0.6 GO:0060004 reflex(GO:0060004)
0.0 0.9 GO:0043171 peptide catabolic process(GO:0043171)
0.0 1.0 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 0.6 GO:0048706 embryonic skeletal system development(GO:0048706)
0.0 0.2 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 1.7 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.3 GO:0099565 chemical synaptic transmission, postsynaptic(GO:0099565)
0.0 0.3 GO:0033194 response to hydroperoxide(GO:0033194)
0.0 2.2 GO:0006261 DNA-dependent DNA replication(GO:0006261)
0.0 0.2 GO:0030901 midbrain development(GO:0030901)
0.0 0.1 GO:0033484 nitric oxide homeostasis(GO:0033484)
0.0 0.1 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0 0.2 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 0.3 GO:0006625 protein targeting to peroxisome(GO:0006625) peroxisomal transport(GO:0043574) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663)
0.0 0.6 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 1.8 GO:0008360 regulation of cell shape(GO:0008360)
0.0 1.9 GO:0007160 cell-matrix adhesion(GO:0007160)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.4 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.5 2.2 GO:0008623 CHRAC(GO:0008623)
0.5 1.9 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.4 3.9 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.3 7.9 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.2 1.8 GO:0033269 internode region of axon(GO:0033269)
0.2 1.1 GO:0005796 Golgi lumen(GO:0005796)
0.2 0.7 GO:0042567 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867) insulin-like growth factor ternary complex(GO:0042567)
0.1 2.4 GO:0098644 complex of collagen trimers(GO:0098644)
0.1 0.7 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.1 0.3 GO:0044299 C-fiber(GO:0044299)
0.1 0.8 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.1 0.8 GO:0071439 clathrin complex(GO:0071439)
0.1 0.3 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.1 0.8 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 16.2 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.4 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 16.6 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.5 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.9 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 1.0 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 3.5 GO:0005681 spliceosomal complex(GO:0005681)
0.0 0.7 GO:0005581 collagen trimer(GO:0005581)
0.0 0.1 GO:0030015 CCR4-NOT core complex(GO:0030015)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 8.0 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
1.3 10.2 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.8 3.4 GO:0050436 microfibril binding(GO:0050436)
0.6 7.9 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.5 5.1 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.4 1.9 GO:0050816 phosphothreonine binding(GO:0050816)
0.3 1.2 GO:0019808 polyamine binding(GO:0019808)
0.3 2.3 GO:0039706 co-receptor binding(GO:0039706)
0.2 0.7 GO:0016015 morphogen activity(GO:0016015)
0.2 6.0 GO:0071837 HMG box domain binding(GO:0071837)
0.2 0.7 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.2 0.5 GO:0008502 melatonin receptor activity(GO:0008502)
0.2 1.4 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.2 0.7 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.2 4.1 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.1 3.0 GO:0070016 gamma-catenin binding(GO:0045295) armadillo repeat domain binding(GO:0070016)
0.1 0.4 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.1 0.3 GO:0005110 frizzled-2 binding(GO:0005110)
0.1 2.5 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.1 0.7 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 0.3 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.1 19.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 0.9 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 1.5 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 1.1 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 1.4 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 0.9 GO:0038191 neuropilin binding(GO:0038191)
0.1 0.3 GO:0015254 glycerol channel activity(GO:0015254)
0.1 0.4 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 0.5 GO:0005283 sodium:amino acid symporter activity(GO:0005283)
0.1 1.9 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.1 GO:0001224 RNA polymerase II transcription cofactor binding(GO:0001224) RNA polymerase II transcription corepressor binding(GO:0001226)
0.0 0.3 GO:1904315 GABA-gated chloride ion channel activity(GO:0022851) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0 1.0 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 1.2 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0 2.4 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 4.4 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 0.9 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.8 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 1.0 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.7 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.6 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.6 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.7 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 16.7 GO:0003682 chromatin binding(GO:0003682)
0.0 0.9 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.3 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.4 GO:0005112 Notch binding(GO:0005112)
0.0 0.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.8 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.3 GO:0005248 voltage-gated sodium channel activity(GO:0005248)
0.0 0.5 GO:0017091 AU-rich element binding(GO:0017091)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 20.1 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 3.8 PID_AP1_PATHWAY AP-1 transcription factor network
0.1 2.4 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 1.9 PID_MYC_PATHWAY C-MYC pathway
0.1 3.6 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.1 3.0 PID_BMP_PATHWAY BMP receptor signaling
0.1 1.1 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.1 4.8 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 6.1 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.0 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.4 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.8 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.2 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.6 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.4 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.1 8.0 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 6.6 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 0.9 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 1.2 REACTOME_ACYL_CHAIN_REMODELLING_OF_PG Genes involved in Acyl chain remodelling of PG
0.1 3.6 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.1 4.6 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 0.5 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 0.9 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 0.9 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.4 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 1.9 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.7 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.7 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 0.7 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.0 0.3 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 1.3 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.3 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.7 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 1.4 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.4 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 0.2 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.0 0.6 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.8 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation