Motif ID: Hey2

Z-value: 0.652


Transcription factors associated with Hey2:

Gene SymbolEntrez IDGene Name
Hey2 ENSMUSG00000019789.8 Hey2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hey2mm10_v2_chr10_-_30842765_30842801-0.362.0e-02Click!


Activity profile for motif Hey2.

activity profile for motif Hey2


Sorted Z-values histogram for motif Hey2

Sorted Z-values for motif Hey2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hey2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_+_105518736 6.932 ENSMUST00000034363.5
Hsd11b2
hydroxysteroid 11-beta dehydrogenase 2
chr8_+_87473116 5.547 ENSMUST00000182650.1
ENSMUST00000182758.1
ENSMUST00000181898.1
Gm2694


predicted gene 2694


chr8_+_87472805 3.707 ENSMUST00000180700.2
ENSMUST00000182174.1
ENSMUST00000181159.1
Gm2694


predicted gene 2694


chr8_+_87472838 3.582 ENSMUST00000180806.2
Gm2694
predicted gene 2694
chr4_+_116877376 3.486 ENSMUST00000044823.3
Zswim5
zinc finger SWIM-type containing 5
chr1_-_127677923 3.449 ENSMUST00000160616.1
Tmem163
transmembrane protein 163
chr6_+_47244359 3.101 ENSMUST00000060839.6
Cntnap2
contactin associated protein-like 2
chr4_-_107683576 2.947 ENSMUST00000131776.1
Dmrtb1
DMRT-like family B with proline-rich C-terminal, 1
chr11_-_120348513 2.783 ENSMUST00000071555.6
Actg1
actin, gamma, cytoplasmic 1
chr4_-_117133953 2.556 ENSMUST00000076859.5
Plk3
polo-like kinase 3
chr1_+_72824482 2.386 ENSMUST00000047328.4
Igfbp2
insulin-like growth factor binding protein 2
chr11_-_120348475 2.113 ENSMUST00000062147.7
ENSMUST00000128055.1
Actg1

actin, gamma, cytoplasmic 1

chr2_-_114013619 1.980 ENSMUST00000090275.4
Gjd2
gap junction protein, delta 2
chr10_-_11080956 1.756 ENSMUST00000105560.1
Grm1
glutamate receptor, metabotropic 1
chr1_+_182763961 1.740 ENSMUST00000153348.1
Susd4
sushi domain containing 4
chr7_+_27486910 1.673 ENSMUST00000008528.7
Sertad1
SERTA domain containing 1
chr9_+_21165714 1.646 ENSMUST00000039413.8
Pde4a
phosphodiesterase 4A, cAMP specific
chr8_+_119446719 1.415 ENSMUST00000098363.3
Necab2
N-terminal EF-hand calcium binding protein 2
chr16_-_18621366 1.411 ENSMUST00000051160.2
Gp1bb
glycoprotein Ib, beta polypeptide
chr10_+_69212634 1.228 ENSMUST00000020101.5
Rhobtb1
Rho-related BTB domain containing 1
chr10_+_80494835 1.223 ENSMUST00000051773.8
Onecut3
one cut domain, family member 3
chr8_-_116732991 1.170 ENSMUST00000109102.2
Cdyl2
chromodomain protein, Y chromosome-like 2
chr7_-_4752972 1.147 ENSMUST00000183971.1
ENSMUST00000182173.1
ENSMUST00000182738.1
ENSMUST00000184143.1
ENSMUST00000182111.1
ENSMUST00000182048.1
ENSMUST00000063324.7
Cox6b2






cytochrome c oxidase subunit VIb polypeptide 2






chr19_+_22139028 1.139 ENSMUST00000099569.2
ENSMUST00000087576.4
ENSMUST00000074770.5
Trpm3


transient receptor potential cation channel, subfamily M, member 3


chr5_-_110448486 1.107 ENSMUST00000069483.5
Fbrsl1
fibrosin-like 1
chr1_+_17727034 1.080 ENSMUST00000159958.1
ENSMUST00000160305.1
ENSMUST00000095075.4
Crispld1


cysteine-rich secretory protein LCCL domain containing 1


chr10_+_69212676 1.071 ENSMUST00000167384.1
Rhobtb1
Rho-related BTB domain containing 1
chr4_+_129058133 1.039 ENSMUST00000030584.4
ENSMUST00000168461.1
ENSMUST00000152565.1
Rnf19b


ring finger protein 19B


chr8_-_70700070 0.998 ENSMUST00000116172.1
Gm11175
predicted gene 11175
chr1_+_172481788 0.941 ENSMUST00000127052.1
Igsf9
immunoglobulin superfamily, member 9
chr3_-_88177671 0.934 ENSMUST00000181837.1
1700113A16Rik
RIKEN cDNA 1700113A16 gene
chr17_-_47611449 0.930 ENSMUST00000024783.8
Bysl
bystin-like
chr1_+_172482199 0.924 ENSMUST00000135267.1
ENSMUST00000052629.6
ENSMUST00000111235.2
Igsf9


immunoglobulin superfamily, member 9


chr4_+_33924632 0.913 ENSMUST00000057188.6
Cnr1
cannabinoid receptor 1 (brain)
chr1_-_52500679 0.911 ENSMUST00000069792.7
Nab1
Ngfi-A binding protein 1
chr5_+_92897981 0.905 ENSMUST00000113051.2
Shroom3
shroom family member 3
chr13_-_68999518 0.896 ENSMUST00000022013.7
Adcy2
adenylate cyclase 2
chr5_-_25100624 0.858 ENSMUST00000030784.7
Prkag2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr4_+_128654686 0.849 ENSMUST00000030588.6
ENSMUST00000136377.1
Phc2

polyhomeotic-like 2 (Drosophila)

chr10_+_128083273 0.832 ENSMUST00000026459.5
Atp5b
ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit
chrX_-_52165252 0.823 ENSMUST00000033450.2
Gpc4
glypican 4
chr7_+_101321703 0.820 ENSMUST00000174291.1
ENSMUST00000167888.2
ENSMUST00000172662.1
ENSMUST00000173270.1
ENSMUST00000174083.1
Stard10




START domain containing 10




chr14_-_67933512 0.815 ENSMUST00000039135.4
Dock5
dedicator of cytokinesis 5
chr18_-_61911783 0.814 ENSMUST00000049378.8
ENSMUST00000166783.1
Ablim3

actin binding LIM protein family, member 3

chr11_-_120348091 0.812 ENSMUST00000106215.4
Actg1
actin, gamma, cytoplasmic 1
chr5_-_138996087 0.807 ENSMUST00000110897.1
Pdgfa
platelet derived growth factor, alpha
chr7_-_34655500 0.806 ENSMUST00000032709.1
Kctd15
potassium channel tetramerisation domain containing 15
chr11_+_103966716 0.788 ENSMUST00000057921.3
ENSMUST00000063347.5
Arf2

ADP-ribosylation factor 2

chr13_-_25270076 0.781 ENSMUST00000057866.6
Nrsn1
neurensin 1
chr5_-_36398090 0.765 ENSMUST00000037370.7
ENSMUST00000070720.6
Sorcs2

sortilin-related VPS10 domain containing receptor 2

chr5_+_33018816 0.761 ENSMUST00000019109.7
Ywhah
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
chr13_-_14523178 0.753 ENSMUST00000110516.2
Hecw1
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
chr5_-_110387090 0.748 ENSMUST00000056124.6
Fbrsl1
fibrosin-like 1
chr4_-_129239165 0.706 ENSMUST00000097873.3
C77080
expressed sequence C77080
chr11_+_101155884 0.698 ENSMUST00000043654.9
Tubg2
tubulin, gamma 2
chr7_-_27166413 0.678 ENSMUST00000108382.1
Egln2
EGL nine homolog 2 (C. elegans)
chr7_+_79500018 0.656 ENSMUST00000182495.1
ENSMUST00000183043.1
AI854517

expressed sequence AI854517

chr15_-_76009440 0.646 ENSMUST00000170153.1
Fam83h
family with sequence similarity 83, member H
chr14_+_66297029 0.645 ENSMUST00000022623.6
ENSMUST00000121006.1
Trim35

tripartite motif-containing 35

chr15_+_101174096 0.629 ENSMUST00000000544.9
Acvr1b
activin A receptor, type 1B
chr7_+_97696634 0.618 ENSMUST00000026506.4
Clns1a
chloride channel, nucleotide-sensitive, 1A
chr5_-_149051300 0.592 ENSMUST00000110505.1
Hmgb1
high mobility group box 1
chr4_+_148804420 0.579 ENSMUST00000094464.3
ENSMUST00000122222.1
Casz1

castor zinc finger 1

chr10_-_112928974 0.571 ENSMUST00000099276.2
Atxn7l3b
ataxin 7-like 3B
chr5_+_36484578 0.560 ENSMUST00000060100.1
Ccdc96
coiled-coil domain containing 96
chr3_+_87906321 0.542 ENSMUST00000005017.8
Hdgf
hepatoma-derived growth factor
chr9_+_103112072 0.523 ENSMUST00000035155.6
Rab6b
RAB6B, member RAS oncogene family
chr8_+_4349588 0.505 ENSMUST00000110982.1
ENSMUST00000024004.7
Ccl25

chemokine (C-C motif) ligand 25

chr1_-_156939626 0.498 ENSMUST00000063199.6
ENSMUST00000027886.7
ENSMUST00000172057.1
Ralgps2


Ral GEF with PH domain and SH3 binding motif 2


chr19_-_5729618 0.498 ENSMUST00000116558.2
ENSMUST00000099955.3
ENSMUST00000161368.1
Fam89b


family with sequence similarity 89, member B


chr12_+_80518990 0.495 ENSMUST00000021558.6
Galnt16
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 16
chr3_+_103968588 0.495 ENSMUST00000156262.1
Phtf1
putative homeodomain transcription factor 1
chr1_+_131910458 0.493 ENSMUST00000062264.6
Nucks1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr16_-_4624984 0.493 ENSMUST00000014445.6
Pam16
presequence translocase-asssociated motor 16 homolog (S. cerevisiae)
chr1_-_156939387 0.476 ENSMUST00000171292.1
Ralgps2
Ral GEF with PH domain and SH3 binding motif 2
chr16_+_92058270 0.473 ENSMUST00000047429.8
ENSMUST00000113975.2
Mrps6
Slc5a3
mitochondrial ribosomal protein S6
solute carrier family 5 (inositol transporters), member 3
chr4_+_85205120 0.462 ENSMUST00000107188.3
Sh3gl2
SH3-domain GRB2-like 2
chr8_-_23257043 0.453 ENSMUST00000051094.6
Golga7
golgi autoantigen, golgin subfamily a, 7
chr18_-_36454487 0.453 ENSMUST00000025204.5
Pfdn1
prefoldin 1
chr7_+_44384604 0.451 ENSMUST00000130707.1
ENSMUST00000130844.1
Syt3

synaptotagmin III

chr8_-_23257009 0.448 ENSMUST00000121783.1
Golga7
golgi autoantigen, golgin subfamily a, 7
chr6_-_11907419 0.442 ENSMUST00000031637.5
Ndufa4
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4
chr11_-_115419917 0.435 ENSMUST00000106537.1
ENSMUST00000043931.2
ENSMUST00000073791.3
Atp5h


ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d


chr16_+_94085226 0.435 ENSMUST00000072182.7
Sim2
single-minded homolog 2 (Drosophila)
chrX_+_71555918 0.434 ENSMUST00000072699.6
ENSMUST00000114582.2
ENSMUST00000015361.4
ENSMUST00000088874.3
Hmgb3



high mobility group box 3



chr3_-_89418287 0.433 ENSMUST00000029679.3
Cks1b
CDC28 protein kinase 1b
chr10_+_7667503 0.429 ENSMUST00000040135.8
Nup43
nucleoporin 43
chr1_-_93445642 0.422 ENSMUST00000042498.7
Hdlbp
high density lipoprotein (HDL) binding protein
chr11_-_100939357 0.418 ENSMUST00000092671.5
ENSMUST00000103114.1
Stat3

signal transducer and activator of transcription 3

chr10_-_61452658 0.414 ENSMUST00000167087.1
ENSMUST00000020288.7
Eif4ebp2

eukaryotic translation initiation factor 4E binding protein 2

chr3_+_103968110 0.413 ENSMUST00000117150.1
ENSMUST00000063717.7
ENSMUST00000055425.8
ENSMUST00000123611.1
ENSMUST00000090685.4
Phtf1




putative homeodomain transcription factor 1




chr2_+_167503089 0.411 ENSMUST00000078050.6
Rnf114
ring finger protein 114
chr19_+_6418731 0.408 ENSMUST00000113462.1
ENSMUST00000077182.6
ENSMUST00000113461.1
Nrxn2


neurexin II


chr11_+_120721452 0.403 ENSMUST00000018156.5
Rac3
RAS-related C3 botulinum substrate 3
chr2_-_85196697 0.394 ENSMUST00000099930.2
ENSMUST00000111601.1
Lrrc55

leucine rich repeat containing 55

chr7_-_90457167 0.392 ENSMUST00000032844.5
Tmem126a
transmembrane protein 126A
chr13_-_49652714 0.391 ENSMUST00000021818.7
Cenpp
centromere protein P
chr5_-_24842579 0.386 ENSMUST00000030787.8
Rheb
Ras homolog enriched in brain
chr7_+_79500081 0.379 ENSMUST00000181511.2
ENSMUST00000182937.1
AI854517

expressed sequence AI854517

chr9_+_66713719 0.376 ENSMUST00000085420.5
Car12
carbonic anyhydrase 12
chr5_+_67260794 0.353 ENSMUST00000161369.1
Tmem33
transmembrane protein 33
chr10_-_75517324 0.343 ENSMUST00000039796.7
Gucd1
guanylyl cyclase domain containing 1
chrX_-_8074720 0.337 ENSMUST00000115636.3
ENSMUST00000115638.3
Suv39h1

suppressor of variegation 3-9 homolog 1 (Drosophila)

chr14_-_57746044 0.333 ENSMUST00000173990.1
ENSMUST00000022531.7
Lats2

large tumor suppressor 2

chr1_-_166309585 0.330 ENSMUST00000168347.1
5330438I03Rik
RIKEN cDNA 5330438I03 gene
chr7_+_30169861 0.324 ENSMUST00000085668.4
Gm5113
predicted gene 5113
chr9_+_66713686 0.323 ENSMUST00000071889.6
Car12
carbonic anyhydrase 12
chr10_+_80142358 0.308 ENSMUST00000105366.1
Atp5d
ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
chr1_+_152766540 0.307 ENSMUST00000077755.5
ENSMUST00000097536.4
Arpc5

actin related protein 2/3 complex, subunit 5

chr17_+_35861318 0.300 ENSMUST00000074259.8
ENSMUST00000174873.1
Nrm

nurim (nuclear envelope membrane protein)

chr5_+_111733924 0.294 ENSMUST00000180627.1
Gm26897
predicted gene, 26897
chr14_-_33447142 0.293 ENSMUST00000111944.3
ENSMUST00000022504.5
ENSMUST00000111945.2
Mapk8


mitogen-activated protein kinase 8


chr7_-_62420139 0.271 ENSMUST00000094340.3
Mkrn3
makorin, ring finger protein, 3
chr10_+_80142295 0.261 ENSMUST00000003156.8
Atp5d
ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
chr15_-_79328201 0.259 ENSMUST00000173163.1
ENSMUST00000047816.8
ENSMUST00000172403.2
ENSMUST00000173632.1
Pla2g6



phospholipase A2, group VI



chr14_-_31128924 0.256 ENSMUST00000064032.4
ENSMUST00000049732.5
ENSMUST00000090205.3
Smim4


small itegral membrane protein 4


chrX_+_140664908 0.255 ENSMUST00000112990.1
ENSMUST00000112988.1
Mid2

midline 2

chr4_+_117835387 0.252 ENSMUST00000169885.1
Slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr15_-_79328154 0.237 ENSMUST00000166977.2
Pla2g6
phospholipase A2, group VI
chr4_+_134468320 0.236 ENSMUST00000030636.4
ENSMUST00000127279.1
ENSMUST00000105867.1
Stmn1


stathmin 1


chr11_+_74830920 0.232 ENSMUST00000000291.2
Mnt
max binding protein
chr7_+_141447645 0.230 ENSMUST00000106004.1
ENSMUST00000106003.1
Rplp2

ribosomal protein, large P2

chr1_+_178187721 0.221 ENSMUST00000159284.1
Desi2
desumoylating isopeptidase 2
chr17_-_34122311 0.203 ENSMUST00000025193.6
Brd2
bromodomain containing 2
chr1_+_92906959 0.198 ENSMUST00000060913.6
Dusp28
dual specificity phosphatase 28
chr15_+_100615620 0.194 ENSMUST00000000356.8
Dazap2
DAZ associated protein 2
chr1_-_60566708 0.193 ENSMUST00000027168.5
ENSMUST00000090293.4
ENSMUST00000140485.1
Raph1


Ras association (RalGDS/AF-6) and pleckstrin homology domains 1


chr18_+_76242135 0.188 ENSMUST00000172198.1
Smad2
SMAD family member 2
chr6_-_88518760 0.186 ENSMUST00000032168.5
Sec61a1
Sec61 alpha 1 subunit (S. cerevisiae)
chr14_-_55784007 0.185 ENSMUST00000002398.7
Adcy4
adenylate cyclase 4
chr12_+_86678685 0.185 ENSMUST00000021681.3
Vash1
vasohibin 1
chr10_+_80141457 0.178 ENSMUST00000105367.1
Atp5d
ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
chr15_+_39112868 0.168 ENSMUST00000022909.8
Dcaf13
DDB1 and CUL4 associated factor 13
chr1_+_180904274 0.167 ENSMUST00000027802.7
Pycr2
pyrroline-5-carboxylate reductase family, member 2
chr9_-_103480328 0.158 ENSMUST00000124310.2
Bfsp2
beaded filament structural protein 2, phakinin
chr1_+_120340569 0.156 ENSMUST00000037286.8
C1ql2
complement component 1, q subcomponent-like 2
chr11_+_120721543 0.152 ENSMUST00000142229.1
Rac3
RAS-related C3 botulinum substrate 3
chr3_-_95882031 0.148 ENSMUST00000161994.1
Gm129
predicted gene 129
chr17_-_34121944 0.146 ENSMUST00000151986.1
Brd2
bromodomain containing 2
chr11_-_12026237 0.145 ENSMUST00000150972.1
Grb10
growth factor receptor bound protein 10
chr17_-_27909206 0.143 ENSMUST00000114848.1
Taf11
TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr7_-_4684963 0.141 ENSMUST00000079970.4
Hspbp1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr14_-_55784027 0.131 ENSMUST00000170223.1
Adcy4
adenylate cyclase 4
chr9_-_36726374 0.122 ENSMUST00000172702.2
ENSMUST00000172742.1
ENSMUST00000034625.5
Chek1


checkpoint kinase 1


chr11_-_23665862 0.114 ENSMUST00000020523.3
Pex13
peroxisomal biogenesis factor 13
chr13_-_32338565 0.113 ENSMUST00000041859.7
Gmds
GDP-mannose 4, 6-dehydratase
chr4_+_129513581 0.113 ENSMUST00000062356.6
Marcksl1
MARCKS-like 1
chr11_-_58168467 0.113 ENSMUST00000172035.1
ENSMUST00000035604.6
ENSMUST00000102711.2
Gemin5


gem (nuclear organelle) associated protein 5


chr11_-_84880195 0.111 ENSMUST00000067058.2
ENSMUST00000108080.2
Pigw

phosphatidylinositol glycan anchor biosynthesis, class W

chr6_+_125009665 0.109 ENSMUST00000046064.10
ENSMUST00000152752.1
ENSMUST00000088308.3
ENSMUST00000112425.1
ENSMUST00000084275.5
Zfp384




zinc finger protein 384




chr3_-_90052463 0.105 ENSMUST00000029553.9
ENSMUST00000064639.8
ENSMUST00000090908.6
Ubap2l


ubiquitin associated protein 2-like


chr9_+_22156903 0.099 ENSMUST00000148088.1
Pigyl
phosphatidylinositol glycan anchor biosynthesis, class Y-like
chr9_-_108649349 0.098 ENSMUST00000013338.8
Arih2
ariadne homolog 2 (Drosophila)
chr6_+_125192154 0.091 ENSMUST00000032485.5
Mrpl51
mitochondrial ribosomal protein L51
chr11_+_23665615 0.090 ENSMUST00000109525.1
ENSMUST00000020520.4
Pus10

pseudouridylate synthase 10

chr2_-_168742100 0.084 ENSMUST00000109177.1
Atp9a
ATPase, class II, type 9A
chr11_-_115001880 0.079 ENSMUST00000092464.3
AF251705
cDNA sequence AF251705
chr1_+_119526125 0.073 ENSMUST00000183952.1
TMEM185B
Transmembrane protein 185B
chr15_-_91573181 0.071 ENSMUST00000109283.1
Slc2a13
solute carrier family 2 (facilitated glucose transporter), member 13
chr4_+_126753770 0.059 ENSMUST00000102607.3
ENSMUST00000047431.4
ENSMUST00000132660.1
AU040320


expressed sequence AU040320


chr17_-_45686120 0.057 ENSMUST00000143907.1
ENSMUST00000127065.1
Tmem63b

transmembrane protein 63b

chr14_-_79481268 0.055 ENSMUST00000022601.5
Wbp4
WW domain binding protein 4
chr11_-_93955718 0.052 ENSMUST00000072566.4
Nme2
NME/NM23 nucleoside diphosphate kinase 2
chr15_+_58889208 0.048 ENSMUST00000036904.6
Rnf139
ring finger protein 139
chr1_+_87264345 0.045 ENSMUST00000118687.1
ENSMUST00000027472.6
Efhd1

EF hand domain containing 1

chr7_+_80261202 0.035 ENSMUST00000117989.1
Ngrn
neugrin, neurite outgrowth associated
chr3_-_95882193 0.028 ENSMUST00000159863.1
ENSMUST00000159739.1
ENSMUST00000036418.3
Gm129


predicted gene 129


chr3_+_90052814 0.028 ENSMUST00000160640.1
ENSMUST00000029552.6
ENSMUST00000162114.1
ENSMUST00000068798.6
4933434E20Rik



RIKEN cDNA 4933434E20 gene



chr3_+_105452326 0.027 ENSMUST00000098761.3
Kcnd3
potassium voltage-gated channel, Shal-related family, member 3
chr7_-_30729505 0.017 ENSMUST00000006478.8
Tmem147
transmembrane protein 147
chr17_+_47611570 0.017 ENSMUST00000024778.2
Med20
mediator complex subunit 20
chr1_+_164249023 0.016 ENSMUST00000044021.5
Slc19a2
solute carrier family 19 (thiamine transporter), member 2
chr2_-_168741898 0.009 ENSMUST00000109176.1
ENSMUST00000178504.1
Atp9a

ATPase, class II, type 9A

chr1_+_60409612 0.009 ENSMUST00000052332.8
Abi2
abl-interactor 2
chr7_+_35119285 0.003 ENSMUST00000042985.9
Cebpa
CCAAT/enhancer binding protein (C/EBP), alpha

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 1.4 GO:0060167 regulation of adenosine receptor signaling pathway(GO:0060167)
0.6 3.1 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.6 6.9 GO:0001977 renal system process involved in regulation of blood volume(GO:0001977)
0.4 1.8 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.4 1.7 GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002924)
0.4 0.8 GO:0010512 negative regulation of phosphatidylinositol biosynthetic process(GO:0010512)
0.3 0.9 GO:0099552 trans-synaptic signaling by lipid, modulating synaptic transmission(GO:0099552) trans-synaptic signaling by endocannabinoid, modulating synaptic transmission(GO:0099553)
0.3 2.6 GO:0090166 Golgi disassembly(GO:0090166) regulation of chaperone-mediated autophagy(GO:1904714)
0.2 0.8 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.2 0.8 GO:1904694 negative regulation of vascular smooth muscle contraction(GO:1904694)
0.2 0.6 GO:0045819 plasmacytoid dendritic cell activation(GO:0002270) positive regulation of glycogen catabolic process(GO:0045819)
0.2 1.0 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)
0.2 0.5 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
0.2 0.5 GO:0019046 release from viral latency(GO:0019046) regulation of DNA strand elongation(GO:0060382)
0.1 0.6 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552) retinal rod cell differentiation(GO:0060221)
0.1 0.5 GO:1903237 negative regulation of leukocyte tethering or rolling(GO:1903237)
0.1 0.6 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
0.1 2.4 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.1 5.7 GO:0045214 sarcomere organization(GO:0045214)
0.1 0.5 GO:0090238 positive regulation of arachidonic acid secretion(GO:0090238)
0.1 0.4 GO:1903896 positive regulation of IRE1-mediated unfolded protein response(GO:1903896)
0.1 0.8 GO:0032782 bile acid secretion(GO:0032782)
0.1 0.3 GO:0001827 inner cell mass cell fate commitment(GO:0001827)
0.1 0.4 GO:1902724 positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728)
0.1 0.7 GO:0055064 carbon dioxide transport(GO:0015670) chloride ion homeostasis(GO:0055064)
0.1 0.4 GO:0045578 negative regulation of B cell differentiation(GO:0045578)
0.1 0.7 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.1 0.3 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.1 0.9 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 0.5 GO:0015791 polyol transport(GO:0015791)
0.1 0.3 GO:2000017 positive regulation of determination of dorsal identity(GO:2000017)
0.1 0.6 GO:0021894 cerebral cortex GABAergic interneuron development(GO:0021894)
0.1 1.0 GO:0072643 interferon-gamma secretion(GO:0072643)
0.1 0.5 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.1 0.4 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.1 0.6 GO:0045794 negative regulation of cell volume(GO:0045794)
0.1 1.6 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.1 0.8 GO:0006706 steroid catabolic process(GO:0006706)
0.0 0.4 GO:1903818 positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.0 0.4 GO:2000074 regulation of type B pancreatic cell development(GO:2000074)
0.0 0.2 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.0 0.2 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352) positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224)
0.0 0.6 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.0 0.2 GO:1901491 negative regulation of lymphangiogenesis(GO:1901491)
0.0 0.5 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.0 1.2 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.4 GO:0021554 optic nerve development(GO:0021554)
0.0 0.3 GO:0036123 histone H3-K9 dimethylation(GO:0036123)
0.0 0.8 GO:0010800 positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0 0.3 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 1.1 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 0.2 GO:0048793 pronephros development(GO:0048793)
0.0 0.5 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 2.1 GO:0007601 visual perception(GO:0007601)
0.0 0.4 GO:0042297 vocal learning(GO:0042297) imitative learning(GO:0098596)
0.0 1.1 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.9 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 0.2 GO:0006561 proline biosynthetic process(GO:0006561)
0.0 0.6 GO:0045104 intermediate filament cytoskeleton organization(GO:0045104)
0.0 0.1 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.0 0.7 GO:0007020 microtubule nucleation(GO:0007020)
0.0 1.9 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.3 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.4 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 0.1 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.0 0.1 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.0 0.8 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)
0.0 0.6 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.1 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.0 0.1 GO:0019673 GDP-mannose metabolic process(GO:0019673)
0.0 0.9 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.0 0.1 GO:0043923 positive regulation by host of viral transcription(GO:0043923)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0044194 cytolytic granule(GO:0044194)
0.2 0.6 GO:0048179 activin receptor complex(GO:0048179)
0.2 1.6 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.2 0.5 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.2 3.1 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 1.8 GO:0038037 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
0.1 3.4 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 2.0 GO:0005922 connexon complex(GO:0005922)
0.1 0.6 GO:0034715 pICln-Sm protein complex(GO:0034715)
0.1 5.7 GO:0043034 costamere(GO:0043034)
0.1 0.8 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 1.1 GO:0030061 mitochondrial crista(GO:0030061)
0.1 0.9 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.1 0.3 GO:0033553 rDNA heterochromatin(GO:0033553)
0.1 0.6 GO:0045095 keratin filament(GO:0045095)
0.1 0.9 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 1.9 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.2 GO:0032444 activin responsive factor complex(GO:0032444)
0.0 0.8 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.5 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.4 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.6 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.4 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.4 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.7 GO:0000242 pericentriolar material(GO:0000242)
0.0 2.6 GO:0005795 Golgi stack(GO:0005795)
0.0 0.3 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.4 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.9 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.1 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 1.3 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.4 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.9 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.5 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.6 GO:0031941 filamentous actin(GO:0031941)
0.0 0.7 GO:0014704 intercalated disc(GO:0014704)
0.0 0.3 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.8 GO:0005902 microvillus(GO:0005902)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 1.4 GO:0031687 A2A adenosine receptor binding(GO:0031687)
0.5 6.9 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0033764)
0.4 1.8 GO:0001639 PLC activating G-protein coupled glutamate receptor activity(GO:0001639) G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.3 2.4 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.2 0.6 GO:0000402 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)
0.2 0.8 GO:0043532 angiostatin binding(GO:0043532)
0.2 0.6 GO:1990254 keratin filament binding(GO:1990254)
0.2 0.6 GO:0016361 activin receptor activity, type I(GO:0016361)
0.1 0.5 GO:0031735 CCR10 chemokine receptor binding(GO:0031735)
0.1 0.9 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.1 0.4 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.1 1.2 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 0.7 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.1 1.9 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.1 6.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 0.3 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1 0.7 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 0.6 GO:0004016 adenylate cyclase activity(GO:0004016)
0.1 0.8 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 1.6 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.5 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.0 0.4 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.0 1.0 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 0.5 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.3 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 0.2 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.0 0.1 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.0 0.2 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 1.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.4 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.8 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.9 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.5 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.8 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 2.3 GO:0002039 p53 binding(GO:0002039)
0.0 0.3 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.0 3.1 GO:0002020 protease binding(GO:0002020)
0.0 0.1 GO:0030621 U4 snRNA binding(GO:0030621)
0.0 0.4 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.2 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.3 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 1.2 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.4 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.5 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.1 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 3.2 GO:0003924 GTPase activity(GO:0003924)
0.0 0.5 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.4 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.2 GO:0043022 ribosome binding(GO:0043022)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.7 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.6 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.7 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 1.2 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 2.7 PID_P73PATHWAY p73 transcription factor network
0.0 0.4 ST_STAT3_PATHWAY STAT3 Pathway
0.0 0.8 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 3.3 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.6 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.4 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 0.8 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.0 0.2 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.5 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 0.7 PID_RB_1PATHWAY Regulation of retinoblastoma protein

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.0 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.1 2.4 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 1.4 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.1 1.8 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 2.0 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 1.2 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1 0.7 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.1 0.6 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.8 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.0 0.6 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 1.2 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 0.8 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.0 0.4 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.5 REACTOME_ACYL_CHAIN_REMODELLING_OF_PC Genes involved in Acyl chain remodelling of PC
0.0 0.7 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.8 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.3 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.0 0.3 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.5 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 1.2 REACTOME_METABOLISM_OF_NON_CODING_RNA Genes involved in Metabolism of non-coding RNA
0.0 0.5 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.1 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.5 REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.0 2.3 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.3 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 0.5 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.4 REACTOME_G1_PHASE Genes involved in G1 Phase