Motif ID: Foxd1

Z-value: 1.976


Transcription factors associated with Foxd1:

Gene SymbolEntrez IDGene Name
Foxd1 ENSMUSG00000078302.3 Foxd1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxd1mm10_v2_chr13_+_98354234_98354250-0.352.5e-02Click!


Activity profile for motif Foxd1.

activity profile for motif Foxd1


Sorted Z-values histogram for motif Foxd1

Sorted Z-values for motif Foxd1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxd1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_144892813 31.207 ENSMUST00000105744.1
ENSMUST00000171001.1
Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr4_+_144893077 25.087 ENSMUST00000154208.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr4_+_144893127 21.601 ENSMUST00000142808.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr10_-_8518801 14.855 ENSMUST00000061601.7
Ust
uronyl-2-sulfotransferase
chr11_+_3332426 14.624 ENSMUST00000136474.1
Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr8_-_84773381 13.229 ENSMUST00000109764.1
Nfix
nuclear factor I/X
chr13_-_93499803 12.904 ENSMUST00000065537.7
Jmy
junction-mediating and regulatory protein
chr8_+_65618009 12.063 ENSMUST00000110258.1
ENSMUST00000110256.1
ENSMUST00000110255.1
March1


membrane-associated ring finger (C3HC4) 1


chr15_+_3270767 10.719 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
Sepp1



selenoprotein P, plasma, 1



chr16_-_22439570 10.663 ENSMUST00000170393.1
Etv5
ets variant gene 5
chr16_-_22439719 10.558 ENSMUST00000079601.6
Etv5
ets variant gene 5
chr14_-_18239053 10.519 ENSMUST00000090543.5
Nr1d2
nuclear receptor subfamily 1, group D, member 2
chr18_+_69344503 10.515 ENSMUST00000114985.3
Tcf4
transcription factor 4
chr18_+_5593566 10.323 ENSMUST00000160910.1
Zeb1
zinc finger E-box binding homeobox 1
chr11_+_3330781 9.885 ENSMUST00000136536.1
ENSMUST00000093399.4
Pik3ip1

phosphoinositide-3-kinase interacting protein 1

chr12_-_100725028 9.514 ENSMUST00000043599.6
Rps6ka5
ribosomal protein S6 kinase, polypeptide 5
chr11_+_3330401 9.430 ENSMUST00000045153.4
Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr5_+_3928033 8.762 ENSMUST00000143365.1
Akap9
A kinase (PRKA) anchor protein (yotiao) 9
chr19_+_4855129 8.207 ENSMUST00000119694.1
Ctsf
cathepsin F
chr7_+_141476374 8.132 ENSMUST00000117634.1
Tspan4
tetraspanin 4
chr3_+_5218516 7.780 ENSMUST00000175866.1
Zfhx4
zinc finger homeodomain 4
chr7_+_113207465 7.503 ENSMUST00000047321.7
Arntl
aryl hydrocarbon receptor nuclear translocator-like
chr10_+_60106452 7.320 ENSMUST00000165024.2
Spock2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
chr16_-_74411292 7.291 ENSMUST00000117200.1
Robo2
roundabout homolog 2 (Drosophila)
chr11_-_101226414 7.144 ENSMUST00000100417.2
ENSMUST00000107285.1
ENSMUST00000107284.1
Ezh1


enhancer of zeste homolog 1 (Drosophila)


chr11_+_74619594 6.956 ENSMUST00000100866.2
E130309D14Rik
RIKEN cDNA E130309D14 gene
chr19_+_23141183 6.750 ENSMUST00000036884.1
Klf9
Kruppel-like factor 9
chr5_+_107437908 6.638 ENSMUST00000094541.2
Btbd8
BTB (POZ) domain containing 8
chr3_+_96557950 6.558 ENSMUST00000074519.6
ENSMUST00000049093.7
Txnip

thioredoxin interacting protein

chr3_+_5218589 6.533 ENSMUST00000177488.1
Zfhx4
zinc finger homeodomain 4
chr7_+_19359740 6.482 ENSMUST00000140836.1
Ppp1r13l
protein phosphatase 1, regulatory (inhibitor) subunit 13 like
chr1_-_64956807 6.398 ENSMUST00000097713.1
Plekhm3
pleckstrin homology domain containing, family M, member 3
chr16_+_20097554 6.364 ENSMUST00000023509.3
Klhl24
kelch-like 24
chr19_+_26750939 6.334 ENSMUST00000175953.1
Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr1_-_64956731 6.151 ENSMUST00000123225.1
Plekhm3
pleckstrin homology domain containing, family M, member 3
chr3_+_52268337 6.050 ENSMUST00000053764.5
Foxo1
forkhead box O1
chr1_-_97977233 5.840 ENSMUST00000161567.1
Pam
peptidylglycine alpha-amidating monooxygenase
chr12_+_35047180 5.739 ENSMUST00000048519.9
ENSMUST00000163677.1
Snx13

sorting nexin 13

chr2_+_19658055 5.716 ENSMUST00000052168.4
Otud1
OTU domain containing 1
chr3_+_5218546 5.668 ENSMUST00000026284.6
Zfhx4
zinc finger homeodomain 4
chr12_-_84450944 5.626 ENSMUST00000085192.5
Aldh6a1
aldehyde dehydrogenase family 6, subfamily A1
chr13_+_80886095 5.561 ENSMUST00000161441.1
Arrdc3
arrestin domain containing 3
chr15_-_58214882 5.466 ENSMUST00000022986.6
Fbxo32
F-box protein 32
chr2_+_181837854 5.239 ENSMUST00000029116.7
ENSMUST00000108754.1
Pcmtd2

protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2

chr7_+_82175156 5.144 ENSMUST00000180243.1
Sh3gl3
SH3-domain GRB2-like 3
chr2_+_28641227 5.144 ENSMUST00000028155.5
ENSMUST00000113869.1
ENSMUST00000113867.2
Tsc1


tuberous sclerosis 1


chr2_+_112265809 5.132 ENSMUST00000110991.2
Slc12a6
solute carrier family 12, member 6
chr1_+_179546303 5.125 ENSMUST00000040706.8
Cnst
consortin, connexin sorting protein
chr3_-_146770218 5.118 ENSMUST00000106137.1
Prkacb
protein kinase, cAMP dependent, catalytic, beta
chr9_+_45370185 5.068 ENSMUST00000085939.6
Fxyd6
FXYD domain-containing ion transport regulator 6
chr10_-_18234930 4.900 ENSMUST00000052648.8
ENSMUST00000080860.6
ENSMUST00000173243.1
Ccdc28a


coiled-coil domain containing 28A


chr12_-_31950210 4.881 ENSMUST00000176084.1
ENSMUST00000176103.1
ENSMUST00000167458.2
Hbp1


high mobility group box transcription factor 1


chr11_+_69095217 4.861 ENSMUST00000101004.2
Per1
period circadian clock 1
chr6_-_39725193 4.822 ENSMUST00000101497.3
Braf
Braf transforming gene
chr14_-_55560340 4.804 ENSMUST00000066106.3
A730061H03Rik
RIKEN cDNA A730061H03 gene
chr2_+_128126030 4.702 ENSMUST00000089634.5
ENSMUST00000019281.7
ENSMUST00000110341.2
ENSMUST00000103211.1
ENSMUST00000103210.1
Bcl2l11




BCL2-like 11 (apoptosis facilitator)




chr4_+_136357423 4.690 ENSMUST00000182167.1
Gm17388
predicted gene, 17388
chr7_+_126776939 4.649 ENSMUST00000038614.5
ENSMUST00000170882.1
ENSMUST00000106359.1
ENSMUST00000106357.1
ENSMUST00000145762.1
ENSMUST00000132643.1
ENSMUST00000106356.1
Ypel3






yippee-like 3 (Drosophila)






chr18_-_34624562 4.620 ENSMUST00000003876.3
ENSMUST00000115766.1
ENSMUST00000097626.3
ENSMUST00000115765.1
Brd8



bromodomain containing 8



chr5_+_3928267 4.602 ENSMUST00000044492.8
Akap9
A kinase (PRKA) anchor protein (yotiao) 9
chr10_+_29211637 4.547 ENSMUST00000092627.4
9330159F19Rik
RIKEN cDNA 9330159F19 gene
chrX_+_7722267 4.474 ENSMUST00000125991.1
ENSMUST00000148624.1
Wdr45

WD repeat domain 45

chr16_-_4880284 4.462 ENSMUST00000037843.6
Ubald1
UBA-like domain containing 1
chr7_-_44849075 4.455 ENSMUST00000047085.8
Tbc1d17
TBC1 domain family, member 17
chr10_-_26373956 4.433 ENSMUST00000105519.3
ENSMUST00000040219.6
L3mbtl3

l(3)mbt-like 3 (Drosophila)

chr2_-_73312701 4.343 ENSMUST00000058615.9
Cir1
corepressor interacting with RBPJ, 1
chr1_+_36511867 4.285 ENSMUST00000001166.7
ENSMUST00000097776.3
Cnnm3

cyclin M3

chr8_+_20136455 4.229 ENSMUST00000179299.1
ENSMUST00000096485.4
Gm21811

predicted gene, 21811

chr14_+_55560480 4.189 ENSMUST00000121622.1
ENSMUST00000143431.1
ENSMUST00000150481.1
Dcaf11


DDB1 and CUL4 associated factor 11


chr12_-_31950170 4.100 ENSMUST00000176520.1
Hbp1
high mobility group box transcription factor 1
chrX_+_7722214 4.041 ENSMUST00000043045.2
ENSMUST00000116634.1
ENSMUST00000115689.3
ENSMUST00000131077.1
ENSMUST00000115688.1
ENSMUST00000116633.1
Wdr45





WD repeat domain 45





chr16_+_24448082 3.984 ENSMUST00000078988.2
Lpp
LIM domain containing preferred translocation partner in lipoma
chr11_+_85353156 3.962 ENSMUST00000108061.1
ENSMUST00000108062.1
ENSMUST00000108056.1
ENSMUST00000138423.1
ENSMUST00000074875.4
ENSMUST00000092821.3
Bcas3





breast carcinoma amplified sequence 3





chr1_-_45503282 3.758 ENSMUST00000086430.4
Col5a2
collagen, type V, alpha 2
chr8_-_119558718 3.688 ENSMUST00000081381.4
ENSMUST00000098362.3
Mbtps1

membrane-bound transcription factor peptidase, site 1

chr11_-_102556122 3.635 ENSMUST00000143842.1
Gpatch8
G patch domain containing 8
chr9_-_60838200 3.609 ENSMUST00000063858.7
Gm9869
predicted gene 9869
chr9_-_45955170 3.608 ENSMUST00000162072.1
Sidt2
SID1 transmembrane family, member 2
chr18_+_9707639 3.595 ENSMUST00000040069.8
Colec12
collectin sub-family member 12
chr13_+_75089826 3.580 ENSMUST00000022075.4
Pcsk1
proprotein convertase subtilisin/kexin type 1
chr18_-_43059418 3.580 ENSMUST00000025377.7
Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr6_+_30541582 3.569 ENSMUST00000096066.4
Cpa2
carboxypeptidase A2, pancreatic
chr13_-_98815408 3.518 ENSMUST00000040340.8
ENSMUST00000099277.4
ENSMUST00000179563.1
ENSMUST00000109403.1
Fcho2



FCH domain only 2



chr6_+_134830145 3.517 ENSMUST00000046303.5
Crebl2
cAMP responsive element binding protein-like 2
chr1_+_34005872 3.509 ENSMUST00000182296.1
Dst
dystonin
chr14_+_55560904 3.491 ENSMUST00000072530.4
ENSMUST00000128490.1
Dcaf11

DDB1 and CUL4 associated factor 11

chr1_-_179546261 3.452 ENSMUST00000027769.5
Tfb2m
transcription factor B2, mitochondrial
chr8_+_19682268 3.429 ENSMUST00000153710.1
ENSMUST00000127799.1
Gm6483

predicted gene 6483

chr7_+_24907618 3.427 ENSMUST00000151121.1
Arhgef1
Rho guanine nucleotide exchange factor (GEF) 1
chr19_-_28010995 3.366 ENSMUST00000172907.1
ENSMUST00000046898.9
Rfx3

regulatory factor X, 3 (influences HLA class II expression)

chr7_-_80402743 3.313 ENSMUST00000122232.1
Furin
furin (paired basic amino acid cleaving enzyme)
chr13_-_52929458 3.311 ENSMUST00000123599.1
Auh
AU RNA binding protein/enoyl-coenzyme A hydratase
chr15_+_97784355 3.254 ENSMUST00000117892.1
Slc48a1
solute carrier family 48 (heme transporter), member 1
chr2_+_38511643 3.248 ENSMUST00000054234.3
ENSMUST00000112902.1
ENSMUST00000112895.1
Nek6


NIMA (never in mitosis gene a)-related expressed kinase 6


chr5_-_31048014 3.243 ENSMUST00000137223.1
Slc5a6
solute carrier family 5 (sodium-dependent vitamin transporter), member 6
chr13_+_118714678 3.213 ENSMUST00000022246.8
Fgf10
fibroblast growth factor 10
chr3_+_138860489 3.123 ENSMUST00000121826.1
Tspan5
tetraspanin 5
chr2_-_60125651 3.122 ENSMUST00000112550.1
Baz2b
bromodomain adjacent to zinc finger domain, 2B
chr11_+_54438188 3.106 ENSMUST00000046835.7
Fnip1
folliculin interacting protein 1
chr6_+_92940572 3.100 ENSMUST00000181145.1
ENSMUST00000181840.1
9530026P05Rik

RIKEN cDNA 9530026P05 gene

chr7_-_37772868 3.070 ENSMUST00000176205.1
Zfp536
zinc finger protein 536
chr2_+_24976033 3.057 ENSMUST00000045295.7
ENSMUST00000153618.1
ENSMUST00000152777.1
Pnpla7


patatin-like phospholipase domain containing 7


chr13_-_51701041 3.001 ENSMUST00000110042.1
Gm15440
predicted gene 15440
chr2_-_73892530 2.971 ENSMUST00000136958.1
ENSMUST00000112010.2
ENSMUST00000128531.1
ENSMUST00000112017.1
Atf2



activating transcription factor 2



chr19_-_28011138 2.955 ENSMUST00000174850.1
Rfx3
regulatory factor X, 3 (influences HLA class II expression)
chr11_+_114851142 2.953 ENSMUST00000133245.1
ENSMUST00000122967.2
Gprc5c

G protein-coupled receptor, family C, group 5, member C

chr6_-_13677930 2.949 ENSMUST00000045235.5
B630005N14Rik
RIKEN cDNA B630005N14 gene
chr1_-_183297008 2.933 ENSMUST00000057062.5
Brox
BRO1 domain and CAAX motif containing
chr6_-_87809757 2.815 ENSMUST00000032134.7
Rab43
RAB43, member RAS oncogene family
chr15_+_89059712 2.797 ENSMUST00000161372.1
ENSMUST00000162424.1
Panx2

pannexin 2

chr11_-_107348130 2.750 ENSMUST00000134763.1
Pitpnc1
phosphatidylinositol transfer protein, cytoplasmic 1
chr17_+_70561739 2.695 ENSMUST00000097288.2
Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr9_+_110333402 2.681 ENSMUST00000133114.1
ENSMUST00000125759.1
Scap

SREBF chaperone

chr8_-_84978709 2.637 ENSMUST00000064922.5
Junb
Jun-B oncogene
chr4_-_45012093 2.607 ENSMUST00000131991.1
Zbtb5
zinc finger and BTB domain containing 5
chr6_-_5496296 2.575 ENSMUST00000019721.4
Pdk4
pyruvate dehydrogenase kinase, isoenzyme 4
chrX_+_94234921 2.571 ENSMUST00000113908.1
ENSMUST00000113916.3
Klhl15

kelch-like 15

chr12_-_31950535 2.545 ENSMUST00000172314.2
Hbp1
high mobility group box transcription factor 1
chr14_+_55561060 2.496 ENSMUST00000117701.1
Dcaf11
DDB1 and CUL4 associated factor 11
chr11_-_106920359 2.495 ENSMUST00000167787.1
ENSMUST00000092517.2
Smurf2

SMAD specific E3 ubiquitin protein ligase 2

chr11_+_17051818 2.490 ENSMUST00000058159.5
Cnrip1
cannabinoid receptor interacting protein 1
chr9_+_96196246 2.483 ENSMUST00000165120.2
ENSMUST00000034982.9
Tfdp2

transcription factor Dp 2

chr4_+_133130505 2.438 ENSMUST00000084241.5
ENSMUST00000138831.1
Wasf2

WAS protein family, member 2

chr11_+_43433720 2.436 ENSMUST00000126128.1
ENSMUST00000151880.1
ENSMUST00000020681.3
Slu7


SLU7 splicing factor homolog (S. cerevisiae)


chr13_+_104178797 2.403 ENSMUST00000022225.5
ENSMUST00000069187.5
Trim23

tripartite motif-containing 23

chr8_-_3279606 2.380 ENSMUST00000091291.4
Insr
insulin receptor
chr11_-_86993682 2.365 ENSMUST00000018571.4
Ypel2
yippee-like 2 (Drosophila)
chr12_+_52699297 2.352 ENSMUST00000095737.3
Akap6
A kinase (PRKA) anchor protein 6
chr2_+_4718145 2.338 ENSMUST00000056914.6
Bend7
BEN domain containing 7
chr1_-_195131536 2.264 ENSMUST00000075451.6
Cr1l
complement component (3b/4b) receptor 1-like
chr5_-_142817387 2.201 ENSMUST00000036253.6
Tnrc18
trinucleotide repeat containing 18
chr1_-_54926311 2.191 ENSMUST00000179030.1
ENSMUST00000044359.9
Ankrd44

ankyrin repeat domain 44

chrX_+_68678541 2.143 ENSMUST00000088546.5
Fmr1
fragile X mental retardation syndrome 1
chr6_+_135362931 2.141 ENSMUST00000032330.9
Emp1
epithelial membrane protein 1
chr2_-_104028287 2.127 ENSMUST00000056170.3
4931422A03Rik
RIKEN cDNA 4931422A03 gene
chr7_-_37773555 2.109 ENSMUST00000176534.1
Zfp536
zinc finger protein 536
chr12_+_4133394 2.095 ENSMUST00000152065.1
ENSMUST00000127756.1
Adcy3

adenylate cyclase 3

chrX_+_169685191 2.076 ENSMUST00000112104.1
ENSMUST00000112107.1
Mid1

midline 1

chr2_+_52072823 2.059 ENSMUST00000112693.2
ENSMUST00000069794.5
Rif1

Rap1 interacting factor 1 homolog (yeast)

chr7_-_142372210 2.027 ENSMUST00000084412.5
Ifitm10
interferon induced transmembrane protein 10
chr2_-_73892588 2.018 ENSMUST00000154456.1
ENSMUST00000090802.4
ENSMUST00000055833.5
Atf2


activating transcription factor 2


chr6_+_134830216 2.014 ENSMUST00000111937.1
Crebl2
cAMP responsive element binding protein-like 2
chr14_-_68655804 2.009 ENSMUST00000111072.1
ENSMUST00000022642.5
Adam28

a disintegrin and metallopeptidase domain 28

chr8_+_20567716 2.006 ENSMUST00000178995.1
Gm21092
predicted gene, 21092
chr19_+_42090422 2.004 ENSMUST00000066778.4
Pi4k2a
phosphatidylinositol 4-kinase type 2 alpha
chr15_+_25940846 1.971 ENSMUST00000110438.1
Fam134b
family with sequence similarity 134, member B
chr12_-_85270564 1.946 ENSMUST00000019378.6
ENSMUST00000166821.1
Mlh3

mutL homolog 3 (E coli)

chr5_-_31047998 1.885 ENSMUST00000114665.1
ENSMUST00000006817.4
Slc5a6

solute carrier family 5 (sodium-dependent vitamin transporter), member 6

chrX_+_68678624 1.856 ENSMUST00000114656.1
Fmr1
fragile X mental retardation syndrome 1
chr15_+_25752860 1.838 ENSMUST00000022882.5
ENSMUST00000135173.1
Myo10

myosin X

chrX_-_7740206 1.837 ENSMUST00000128289.1
Ccdc120
coiled-coil domain containing 120
chr2_+_176236860 1.834 ENSMUST00000166464.1
2210418O10Rik
RIKEN cDNA 2210418O10 gene
chr2_+_112284561 1.804 ENSMUST00000053666.7
Slc12a6
solute carrier family 12, member 6
chr13_+_55209776 1.781 ENSMUST00000099490.2
Nsd1
nuclear receptor-binding SET-domain protein 1
chr5_-_142817654 1.702 ENSMUST00000151477.1
Tnrc18
trinucleotide repeat containing 18
chr5_+_31048627 1.702 ENSMUST00000013766.6
ENSMUST00000173215.1
ENSMUST00000153643.1
ENSMUST00000114659.2
Atraid



all-trans retinoic acid induced differentiation factor



chr5_-_138171216 1.691 ENSMUST00000147920.1
Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
chr2_-_104712122 1.680 ENSMUST00000111118.1
ENSMUST00000028597.3
Tcp11l1

t-complex 11 like 1

chr7_-_29505447 1.668 ENSMUST00000183096.1
ENSMUST00000085809.4
Sipa1l3

signal-induced proliferation-associated 1 like 3

chr5_+_14025305 1.644 ENSMUST00000073957.6
Sema3e
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr4_-_45012287 1.640 ENSMUST00000055028.8
ENSMUST00000180217.1
ENSMUST00000107817.2
Zbtb5


zinc finger and BTB domain containing 5


chr2_-_73892619 1.628 ENSMUST00000112007.1
ENSMUST00000112016.2
Atf2

activating transcription factor 2

chr12_+_71016658 1.610 ENSMUST00000125125.1
Arid4a
AT rich interactive domain 4A (RBP1-like)
chr11_-_121388186 1.607 ENSMUST00000106107.2
Rab40b
Rab40b, member RAS oncogene family
chr9_-_45955226 1.598 ENSMUST00000038488.9
Sidt2
SID1 transmembrane family, member 2
chrX_+_94234594 1.589 ENSMUST00000153900.1
Klhl15
kelch-like 15
chr11_-_107470699 1.580 ENSMUST00000103064.3
Pitpnc1
phosphatidylinositol transfer protein, cytoplasmic 1
chr15_+_5185700 1.524 ENSMUST00000081640.5
Ttc33
tetratricopeptide repeat domain 33
chrX_+_101254528 1.520 ENSMUST00000062000.4
Foxo4
forkhead box O4
chr4_-_59549243 1.493 ENSMUST00000173699.1
ENSMUST00000173884.1
ENSMUST00000102883.4
ENSMUST00000174586.1
Ptbp3



polypyrimidine tract binding protein 3



chr11_+_107547925 1.488 ENSMUST00000100305.1
ENSMUST00000075012.1
ENSMUST00000106746.1
Helz


helicase with zinc finger domain


chrX_+_35888808 1.476 ENSMUST00000033419.6
Dock11
dedicator of cytokinesis 11
chr15_-_79546741 1.471 ENSMUST00000054014.7
Ddx17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr13_-_103920295 1.468 ENSMUST00000169083.1
Erbb2ip
Erbb2 interacting protein
chr15_-_53346118 1.452 ENSMUST00000077273.2
Ext1
exostoses (multiple) 1
chr14_+_64589802 1.434 ENSMUST00000180610.1
A930011O12Rik
RIKEN cDNA A930011O12 gene
chr15_+_5185519 1.423 ENSMUST00000118193.1
ENSMUST00000022751.8
Ttc33

tetratricopeptide repeat domain 33

chr13_-_52929640 1.419 ENSMUST00000120535.1
ENSMUST00000119311.1
ENSMUST00000021913.9
ENSMUST00000110031.3
Auh



AU RNA binding protein/enoyl-coenzyme A hydratase



chr5_+_21372642 1.407 ENSMUST00000035799.5
Fgl2
fibrinogen-like protein 2
chr19_+_29101375 1.389 ENSMUST00000064393.5
Rcl1
RNA terminal phosphate cyclase-like 1
chr3_+_32436376 1.383 ENSMUST00000108242.1
Pik3ca
phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
chr6_+_15185203 1.352 ENSMUST00000154448.1
Foxp2
forkhead box P2
chr5_+_31251678 1.340 ENSMUST00000054829.7
ENSMUST00000114570.1
ENSMUST00000075611.7
Krtcap3


keratinocyte associated protein 3


chr6_+_53573364 1.327 ENSMUST00000047450.7
Creb5
cAMP responsive element binding protein 5
chr6_-_106800051 1.327 ENSMUST00000013882.7
ENSMUST00000049675.4
ENSMUST00000113239.3
Crbn


cereblon


chr11_+_70214105 1.287 ENSMUST00000094055.3
ENSMUST00000136328.1
ENSMUST00000126296.1
ENSMUST00000153993.2
Slc16a11



solute carrier family 16 (monocarboxylic acid transporters), member 11



chr6_+_29853746 1.243 ENSMUST00000064872.6
ENSMUST00000152581.1
ENSMUST00000176265.1
ENSMUST00000154079.1
Ahcyl2



S-adenosylhomocysteine hydrolase-like 2



chr5_-_122989260 1.210 ENSMUST00000118027.1
Kdm2b
lysine (K)-specific demethylase 2B
chr3_+_32436151 1.159 ENSMUST00000029201.7
Pik3ca
phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
chr3_-_144202300 1.159 ENSMUST00000121796.1
ENSMUST00000121112.1
Lmo4

LIM domain only 4

chr4_-_154160632 1.154 ENSMUST00000105639.3
ENSMUST00000030896.8
Tprgl

transformation related protein 63 regulated like

chr7_+_44849581 1.148 ENSMUST00000150335.1
ENSMUST00000107882.1
Akt1s1

AKT1 substrate 1 (proline-rich)

chr5_-_122989086 1.123 ENSMUST00000046073.9
Kdm2b
lysine (K)-specific demethylase 2B
chr14_-_70766598 1.101 ENSMUST00000167242.1
ENSMUST00000022696.6
Xpo7

exportin 7

chr5_+_142629537 1.036 ENSMUST00000036872.9
ENSMUST00000110778.1
Wipi2

WD repeat domain, phosphoinositide interacting 2

chr6_-_88874045 1.032 ENSMUST00000038409.5
Podxl2
podocalyxin-like 2
chr2_-_51972990 1.032 ENSMUST00000145481.1
ENSMUST00000112705.2
Nmi

N-myc (and STAT) interactor

chr5_-_122988533 1.015 ENSMUST00000086200.4
ENSMUST00000156474.1
Kdm2b

lysine (K)-specific demethylase 2B

chr14_+_54259227 0.993 ENSMUST00000041197.7
Abhd4
abhydrolase domain containing 4
chr3_-_52104891 0.988 ENSMUST00000121440.1
Maml3
mastermind like 3 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
7.1 77.9 GO:0042572 retinol metabolic process(GO:0042572)
4.8 33.9 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
4.2 21.2 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
3.2 12.9 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
3.2 9.5 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
2.5 7.5 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
2.4 7.3 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
2.2 6.6 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
2.1 6.4 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
1.9 5.6 GO:0019482 beta-alanine metabolic process(GO:0019482)
1.9 5.6 GO:0090327 negative regulation of locomotion involved in locomotory behavior(GO:0090327)
1.8 5.5 GO:0014877 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
1.7 5.1 GO:0043379 rRNA export from nucleus(GO:0006407) memory T cell differentiation(GO:0043379) response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650)
1.7 5.1 GO:0090004 positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
1.7 5.0 GO:0099547 regulation of translation at synapse, modulating synaptic transmission(GO:0099547) regulation of translation at postsynapse, modulating synaptic transmission(GO:0099578) positive regulation of intracellular transport of viral material(GO:1901254)
1.6 6.3 GO:0002069 columnar/cuboidal epithelial cell maturation(GO:0002069)
1.5 13.5 GO:0048752 semicircular canal morphogenesis(GO:0048752)
1.3 6.7 GO:0050847 progesterone receptor signaling pathway(GO:0050847)
1.3 5.1 GO:0035461 vitamin transmembrane transport(GO:0035461)
1.3 11.5 GO:0010745 negative regulation of macrophage derived foam cell differentiation(GO:0010745)
1.3 3.8 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
1.2 3.6 GO:0060355 positive regulation of cell adhesion molecule production(GO:0060355)
1.2 4.7 GO:0052151 positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation of apoptotic process by virus(GO:0060139) apoptotic process involved in embryonic digit morphogenesis(GO:1902263)
1.1 3.3 GO:0015886 heme transport(GO:0015886)
1.0 6.9 GO:0035826 rubidium ion transport(GO:0035826) cellular hypotonic response(GO:0071476)
1.0 4.9 GO:0097167 circadian regulation of translation(GO:0097167)
1.0 4.8 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
1.0 10.5 GO:0042118 endothelial cell activation(GO:0042118)
0.9 2.8 GO:0035526 retrograde transport, plasma membrane to Golgi(GO:0035526)
0.9 4.6 GO:2000774 positive regulation of cellular senescence(GO:2000774)
0.9 6.1 GO:0033227 dsRNA transport(GO:0033227)
0.8 2.5 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.8 3.3 GO:0090472 dibasic protein processing(GO:0090472)
0.8 7.3 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.8 2.4 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.8 4.7 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.7 13.4 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.7 13.2 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.7 7.1 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.7 6.3 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.7 9.6 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.7 3.3 GO:0021993 initiation of neural tube closure(GO:0021993)
0.7 2.0 GO:0045575 basophil activation involved in immune response(GO:0002276) basophil activation(GO:0045575)
0.6 2.6 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.6 12.1 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.6 12.0 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)
0.6 2.4 GO:2000481 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316) positive regulation of cAMP-dependent protein kinase activity(GO:2000481)
0.5 6.0 GO:0071455 cellular response to hyperoxia(GO:0071455)
0.5 2.1 GO:0008355 olfactory learning(GO:0008355)
0.5 3.1 GO:2000973 regulation of pro-B cell differentiation(GO:2000973)
0.5 2.5 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
0.5 1.5 GO:1902524 interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) negative regulation of interferon-beta biosynthetic process(GO:0045358) positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.5 5.1 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.4 3.5 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.4 2.1 GO:2001032 regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.4 5.9 GO:0043249 erythrocyte maturation(GO:0043249)
0.4 1.5 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.4 3.6 GO:0009404 toxin metabolic process(GO:0009404)
0.3 6.5 GO:0003215 cardiac right ventricle morphogenesis(GO:0003215)
0.3 2.4 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.3 2.3 GO:2000258 negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.3 1.6 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
0.3 3.6 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.3 4.7 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.3 1.9 GO:0007144 female meiosis I(GO:0007144)
0.3 1.4 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.3 2.6 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.3 1.3 GO:1904721 regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.3 1.8 GO:0000414 regulation of histone H3-K36 methylation(GO:0000414)
0.3 0.8 GO:0017055 negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055)
0.2 1.5 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.2 4.0 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.2 4.6 GO:0043968 histone H2A acetylation(GO:0043968)
0.2 2.1 GO:0035372 protein localization to microtubule(GO:0035372)
0.2 3.4 GO:0031507 heterochromatin assembly(GO:0031507)
0.2 2.7 GO:0070842 aggresome assembly(GO:0070842)
0.2 3.6 GO:0016486 peptide hormone processing(GO:0016486)
0.2 5.7 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.2 1.5 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.2 0.8 GO:0034239 regulation of macrophage fusion(GO:0034239)
0.2 1.0 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.2 0.5 GO:0007525 somatic muscle development(GO:0007525)
0.2 1.2 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.2 1.7 GO:0033689 negative regulation of osteoblast proliferation(GO:0033689)
0.2 3.5 GO:0008090 retrograde axonal transport(GO:0008090)
0.1 1.3 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.1 2.0 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.1 0.9 GO:0018243 protein O-linked glycosylation via threonine(GO:0018243)
0.1 2.1 GO:0032060 bleb assembly(GO:0032060)
0.1 2.4 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592) megakaryocyte development(GO:0035855)
0.1 0.5 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.1 5.8 GO:0046326 positive regulation of glucose import(GO:0046326)
0.1 2.7 GO:0032933 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.1 1.0 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.1 1.0 GO:0031125 rRNA 3'-end processing(GO:0031125)
0.1 15.2 GO:0030010 establishment of cell polarity(GO:0030010)
0.1 6.5 GO:0048008 platelet-derived growth factor receptor signaling pathway(GO:0048008)
0.1 2.7 GO:0048268 clathrin coat assembly(GO:0048268)
0.1 1.3 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.1 5.1 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.1 0.7 GO:0032264 IMP salvage(GO:0032264)
0.1 2.8 GO:0002931 response to ischemia(GO:0002931)
0.1 3.2 GO:0031572 G2 DNA damage checkpoint(GO:0031572)
0.1 0.4 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.1 2.4 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.1 0.8 GO:0043970 histone H3-K9 acetylation(GO:0043970)
0.1 1.4 GO:0019835 cytolysis(GO:0019835)
0.1 5.3 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.1 0.8 GO:0021527 spinal cord association neuron differentiation(GO:0021527) regulation of cell fate specification(GO:0042659)
0.1 3.7 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.1 1.6 GO:0001953 negative regulation of cell-matrix adhesion(GO:0001953)
0.0 0.5 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.0 0.5 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 3.0 GO:0007601 visual perception(GO:0007601)
0.0 4.3 GO:0046488 phosphatidylinositol metabolic process(GO:0046488)
0.0 1.3 GO:0060612 adipose tissue development(GO:0060612)
0.0 0.5 GO:0045807 positive regulation of endocytosis(GO:0045807)
0.0 1.2 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.0 0.7 GO:0043171 peptide catabolic process(GO:0043171)
0.0 3.5 GO:0016042 lipid catabolic process(GO:0016042)
0.0 0.2 GO:0010216 maintenance of DNA methylation(GO:0010216)
0.0 0.2 GO:1990403 embryonic brain development(GO:1990403)
0.0 0.1 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.0 0.5 GO:0007218 neuropeptide signaling pathway(GO:0007218)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 13.4 GO:0044307 dendritic branch(GO:0044307)
1.7 5.1 GO:0033596 TSC1-TSC2 complex(GO:0033596)
1.3 3.8 GO:0005588 collagen type V trimer(GO:0005588)
1.2 5.0 GO:1902737 viral replication complex(GO:0019034) dendritic filopodium(GO:1902737)
1.2 3.5 GO:0098835 presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835)
0.9 7.5 GO:0033391 chromatoid body(GO:0033391)
0.9 3.5 GO:0031673 H zone(GO:0031673)
0.8 2.5 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.8 2.4 GO:0005899 insulin receptor complex(GO:0005899)
0.6 9.6 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.5 6.4 GO:0030057 desmosome(GO:0030057)
0.4 2.6 GO:0035976 AP1 complex(GO:0035976)
0.4 4.7 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.4 4.6 GO:0000812 Swr1 complex(GO:0000812)
0.4 5.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.4 12.1 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.3 6.3 GO:0071564 npBAF complex(GO:0071564)
0.3 3.4 GO:0005677 chromatin silencing complex(GO:0005677)
0.3 7.1 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.3 11.5 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.3 2.1 GO:0001940 male pronucleus(GO:0001940)
0.3 1.7 GO:0061689 tricellular tight junction(GO:0061689)
0.2 1.9 GO:0032300 mismatch repair complex(GO:0032300)
0.2 3.3 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.2 4.0 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.2 6.6 GO:0035861 site of double-strand break(GO:0035861)
0.2 2.4 GO:0031209 SCAR complex(GO:0031209)
0.2 4.1 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.2 7.3 GO:0030673 axolemma(GO:0030673)
0.2 3.3 GO:0031519 PcG protein complex(GO:0031519)
0.2 6.9 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 1.0 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.1 2.4 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 6.5 GO:0045171 intercellular bridge(GO:0045171)
0.1 2.0 GO:0031083 BLOC-1 complex(GO:0031083)
0.1 2.8 GO:0005921 gap junction(GO:0005921)
0.1 2.1 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 7.4 GO:0030667 secretory granule membrane(GO:0030667)
0.1 6.6 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 0.5 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.1 5.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 3.5 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 25.9 GO:0016607 nuclear speck(GO:0016607)
0.1 5.1 GO:0031526 brush border membrane(GO:0031526)
0.1 2.8 GO:0045335 phagocytic vesicle(GO:0045335)
0.1 11.6 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.1 3.6 GO:0005581 collagen trimer(GO:0005581)
0.0 0.1 GO:0034657 GID complex(GO:0034657)
0.0 1.8 GO:0035097 histone methyltransferase complex(GO:0035097)
0.0 6.7 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 2.1 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 13.8 GO:0005667 transcription factor complex(GO:0005667)
0.0 1.8 GO:0016459 myosin complex(GO:0016459)
0.0 8.8 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 11.3 GO:0031252 cell leading edge(GO:0031252)
0.0 2.1 GO:0005795 Golgi stack(GO:0005795)
0.0 2.7 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 3.7 GO:0005802 trans-Golgi network(GO:0005802)
0.0 3.2 GO:0031012 extracellular matrix(GO:0031012)
0.0 84.4 GO:0016021 integral component of membrane(GO:0016021)
0.0 1.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 2.5 GO:0043209 myelin sheath(GO:0043209)
0.0 2.6 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 1.1 GO:0005643 nuclear pore(GO:0005643)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
11.3 33.9 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
11.1 77.9 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
2.6 10.5 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
1.9 5.8 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
1.9 11.3 GO:0004887 thyroid hormone receptor activity(GO:0004887)
1.5 6.1 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
1.3 4.0 GO:0010698 acetyltransferase activator activity(GO:0010698)
1.1 3.3 GO:0015232 heme transporter activity(GO:0015232)
1.1 12.9 GO:0071933 Arp2/3 complex binding(GO:0071933)
1.0 5.2 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
1.0 7.1 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
1.0 6.9 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
1.0 3.0 GO:0005118 sevenless binding(GO:0005118)
0.9 3.5 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.8 2.4 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.8 7.3 GO:0008046 axon guidance receptor activity(GO:0008046)
0.8 7.5 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.7 15.7 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.7 5.0 GO:0033592 RNA strand annealing activity(GO:0033592)
0.7 7.4 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.7 2.0 GO:0035651 AP-3 adaptor complex binding(GO:0035651)
0.6 2.6 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.6 5.1 GO:0071253 connexin binding(GO:0071253)
0.5 3.1 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.5 1.9 GO:0019237 centromeric DNA binding(GO:0019237)
0.5 2.4 GO:0051425 PTB domain binding(GO:0051425)
0.5 5.1 GO:0090482 vitamin transmembrane transporter activity(GO:0090482)
0.5 1.4 GO:0003963 RNA-3'-phosphate cyclase activity(GO:0003963)
0.4 4.0 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.4 3.6 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.4 4.3 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.4 9.6 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.4 4.7 GO:0004300 enoyl-CoA hydratase activity(GO:0004300)
0.3 2.1 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.3 1.0 GO:0071207 histone pre-mRNA stem-loop binding(GO:0071207)
0.3 2.5 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.3 2.8 GO:0005243 gap junction channel activity(GO:0005243)
0.3 3.3 GO:0048406 nerve growth factor binding(GO:0048406)
0.3 1.8 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.3 6.6 GO:0042287 MHC protein binding(GO:0042287)
0.2 3.1 GO:0004622 lysophospholipase activity(GO:0004622)
0.2 5.1 GO:0032794 GTPase activating protein binding(GO:0032794)
0.2 0.9 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.2 1.3 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.2 4.8 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.2 3.6 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.2 6.0 GO:0001223 transcription coactivator binding(GO:0001223)
0.2 1.2 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.2 5.7 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.2 6.3 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.2 5.6 GO:0031690 adrenergic receptor binding(GO:0031690)
0.2 3.2 GO:0042056 chemoattractant activity(GO:0042056)
0.2 4.7 GO:0070840 dynein complex binding(GO:0070840)
0.2 2.3 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 3.2 GO:0001222 transcription corepressor binding(GO:0001222)
0.1 7.3 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 8.1 GO:0003823 antigen binding(GO:0003823)
0.1 5.1 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 3.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 8.2 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 1.1 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.1 0.4 GO:0038049 glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.1 5.6 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.1 7.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 0.7 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.1 0.8 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.1 1.5 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 3.5 GO:0070888 E-box binding(GO:0070888)
0.1 0.5 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.1 5.7 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.1 0.6 GO:0038191 neuropilin binding(GO:0038191)
0.1 2.7 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.1 0.5 GO:0045499 chemorepellent activity(GO:0045499)
0.1 2.7 GO:0032934 cholesterol binding(GO:0015485) sterol binding(GO:0032934)
0.1 0.3 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.1 0.9 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 1.5 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 3.3 GO:0019843 rRNA binding(GO:0019843)
0.0 1.0 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 1.9 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 3.6 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 0.5 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 2.4 GO:0019003 GDP binding(GO:0019003)
0.0 1.6 GO:0001671 ATPase activator activity(GO:0001671)
0.0 1.6 GO:0000975 regulatory region DNA binding(GO:0000975) transcription regulatory region DNA binding(GO:0044212)
0.0 0.1 GO:0043426 MRF binding(GO:0043426)
0.0 14.0 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 1.8 GO:0030507 spectrin binding(GO:0030507)
0.0 1.3 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 1.5 GO:0008146 sulfotransferase activity(GO:0008146)
0.0 1.1 GO:0030331 estrogen receptor binding(GO:0030331)
0.0 10.0 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 8.9 GO:0045296 cadherin binding(GO:0045296)
0.0 5.5 GO:0000287 magnesium ion binding(GO:0000287)
0.0 5.6 GO:0008017 microtubule binding(GO:0008017)
0.0 0.8 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 10.4 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 0.6 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.8 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 0.2 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 1.0 GO:0003712 transcription cofactor activity(GO:0003712)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 89.9 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.7 11.6 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.7 20.8 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.5 11.9 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.4 8.2 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.3 18.3 PID_FOXO_PATHWAY FoxO family signaling
0.2 7.7 PID_IL3_PATHWAY IL3-mediated signaling events
0.2 7.3 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.2 10.3 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.2 7.4 PID_IL12_2PATHWAY IL12-mediated signaling events
0.1 27.4 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 2.7 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 6.5 PID_P53_REGULATION_PATHWAY p53 pathway
0.1 5.1 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.1 2.0 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.1 12.9 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.1 2.6 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 2.4 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.1 1.8 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 3.8 NABA_COLLAGENS Genes encoding collagen proteins
0.1 4.0 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 2.4 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.1 2.0 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.1 4.9 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 3.4 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.1 2.6 PID_ATR_PATHWAY ATR signaling pathway
0.1 3.3 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.1 2.0 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 2.2 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.8 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.7 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 0.5 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.4 NABA_CORE_MATRISOME Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 6.6 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.6 3.6 REACTOME_PEPTIDE_HORMONE_BIOSYNTHESIS Genes involved in Peptide hormone biosynthesis
0.5 13.4 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.5 10.4 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.4 5.1 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.4 3.3 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.3 7.2 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.3 3.7 REACTOME_ACTIVATION_OF_CHAPERONES_BY_ATF6_ALPHA Genes involved in Activation of Chaperones by ATF6-alpha
0.3 4.8 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING Genes involved in Spry regulation of FGF signaling
0.3 10.5 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.3 14.9 REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.3 9.3 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.3 7.5 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.3 4.6 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.2 2.6 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.2 2.9 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.2 7.3 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.2 2.4 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.1 2.0 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 5.1 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 7.3 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 2.5 REACTOME_REGULATION_OF_SIGNALING_BY_CBL Genes involved in Regulation of signaling by CBL
0.1 2.5 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.1 1.7 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.1 0.8 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.1 8.2 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.1 1.9 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.1 1.0 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 3.8 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 0.7 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 4.8 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.7 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.0 1.8 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 0.8 REACTOME_PIP3_ACTIVATES_AKT_SIGNALING Genes involved in PIP3 activates AKT signaling
0.0 3.5 REACTOME_RNA_POL_I_RNA_POL_III_AND_MITOCHONDRIAL_TRANSCRIPTION Genes involved in RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
0.0 0.9 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 1.1 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases