Motif ID: Rest

Z-value: 2.570


Transcription factors associated with Rest:

Gene SymbolEntrez IDGene Name
Rest ENSMUSG00000029249.9 Rest

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Restmm10_v2_chr5_+_77266196_77266232-0.491.2e-03Click!


Activity profile for motif Rest.

activity profile for motif Rest


Sorted Z-values histogram for motif Rest

Sorted Z-values for motif Rest



Network of associatons between targets according to the STRING database.



First level regulatory network of Rest

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_42255704 32.009 ENSMUST00000087123.5
Golga7b
golgi autoantigen, golgin subfamily a, 7B
chr6_-_121473630 25.515 ENSMUST00000046373.5
Iqsec3
IQ motif and Sec7 domain 3
chrX_-_73869804 16.377 ENSMUST00000066576.5
ENSMUST00000114430.1
L1cam

L1 cell adhesion molecule

chr5_-_121009510 16.312 ENSMUST00000079204.5
Rph3a
rabphilin 3A
chr9_+_40269430 14.046 ENSMUST00000171835.2
Scn3b
sodium channel, voltage-gated, type III, beta
chr2_-_25319095 13.895 ENSMUST00000114318.3
ENSMUST00000114310.3
ENSMUST00000114308.3
ENSMUST00000114317.3
ENSMUST00000028335.6
ENSMUST00000114314.3
ENSMUST00000114307.1
Grin1






glutamate receptor, ionotropic, NMDA1 (zeta 1)






chr11_-_35798884 13.084 ENSMUST00000160726.2
Fbll1
fibrillarin-like 1
chr17_-_91092715 13.069 ENSMUST00000160800.2
ENSMUST00000159778.1
ENSMUST00000160844.3
Nrxn1


neurexin I


chr11_+_74619594 12.764 ENSMUST00000100866.2
E130309D14Rik
RIKEN cDNA E130309D14 gene
chr9_+_40269273 12.567 ENSMUST00000176185.1
Scn3b
sodium channel, voltage-gated, type III, beta
chr9_+_40269202 12.318 ENSMUST00000114956.3
ENSMUST00000049941.5
Scn3b

sodium channel, voltage-gated, type III, beta

chr12_-_70347536 11.420 ENSMUST00000110520.2
ENSMUST00000110522.2
ENSMUST00000167755.1
Trim9


tripartite motif-containing 9


chr1_+_34579693 11.181 ENSMUST00000052670.8
Amer3
APC membrane recruitment 3
chr7_-_27396542 10.936 ENSMUST00000108363.1
Sptbn4
spectrin beta, non-erythrocytic 4
chr2_+_132781278 10.730 ENSMUST00000028826.3
Chgb
chromogranin B
chr13_-_54749627 10.543 ENSMUST00000099506.1
Gprin1
G protein-regulated inducer of neurite outgrowth 1
chr18_-_31447383 10.470 ENSMUST00000025110.3
Syt4
synaptotagmin IV
chr11_+_80477015 10.427 ENSMUST00000053413.10
ENSMUST00000147694.1
Cdk5r1

cyclin-dependent kinase 5, regulatory subunit 1 (p35)

chr4_+_101550411 10.274 ENSMUST00000094953.4
ENSMUST00000106933.1
Dnajc6

DnaJ (Hsp40) homolog, subfamily C, member 6

chr3_-_80802789 10.195 ENSMUST00000107745.1
ENSMUST00000075316.4
Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr12_+_102949450 10.152 ENSMUST00000179002.1
Unc79
unc-79 homolog (C. elegans)
chr9_+_59578192 9.674 ENSMUST00000118549.1
ENSMUST00000034840.3
Celf6

CUGBP, Elav-like family member 6

chr12_-_112511136 9.481 ENSMUST00000066791.5
Tmem179
transmembrane protein 179
chr13_-_54749849 8.562 ENSMUST00000135343.1
Gprin1
G protein-regulated inducer of neurite outgrowth 1
chr15_-_76521902 8.500 ENSMUST00000164703.1
ENSMUST00000096365.3
Scrt1

scratch homolog 1, zinc finger protein (Drosophila)

chr11_-_3774706 8.396 ENSMUST00000155197.1
Osbp2
oxysterol binding protein 2
chr7_-_81493725 8.385 ENSMUST00000119121.1
Ap3b2
adaptor-related protein complex 3, beta 2 subunit
chrX_-_20920911 8.304 ENSMUST00000081893.6
ENSMUST00000115345.1
Syn1

synapsin I

chr17_+_28575718 8.179 ENSMUST00000080780.6
Lhfpl5
lipoma HMGIC fusion partner-like 5
chr2_-_25319187 7.995 ENSMUST00000114312.1
Grin1
glutamate receptor, ionotropic, NMDA1 (zeta 1)
chr7_-_81493883 7.900 ENSMUST00000082090.7
Ap3b2
adaptor-related protein complex 3, beta 2 subunit
chr2_+_153031852 7.627 ENSMUST00000037235.6
Xkr7
X Kell blood group precursor related family member 7 homolog
chr2_-_27142429 7.514 ENSMUST00000151224.2
Fam163b
family with sequence similarity 163, member B
chr7_+_27653906 7.420 ENSMUST00000008088.7
Ttc9b
tetratricopeptide repeat domain 9B
chr1_-_84696182 7.356 ENSMUST00000049126.6
Dner
delta/notch-like EGF-related receptor
chr9_+_108826320 7.280 ENSMUST00000024238.5
Celsr3
cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)
chr3_-_89764581 7.199 ENSMUST00000029562.3
Chrnb2
cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)
chr2_-_181314500 7.156 ENSMUST00000103045.3
Stmn3
stathmin-like 3
chr9_-_57467985 6.944 ENSMUST00000046587.6
Scamp5
secretory carrier membrane protein 5
chr1_+_81077274 6.750 ENSMUST00000068275.5
ENSMUST00000113494.2
Nyap2

neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2

chr5_+_137030275 6.677 ENSMUST00000041543.8
Vgf
VGF nerve growth factor inducible
chr9_+_104569671 6.384 ENSMUST00000057742.8
Cpne4
copine IV
chr2_+_155775333 6.298 ENSMUST00000029141.5
Mmp24
matrix metallopeptidase 24
chrX_+_7638674 6.275 ENSMUST00000128890.1
Syp
synaptophysin
chr7_+_122671401 6.204 ENSMUST00000182095.1
Cacng3
calcium channel, voltage-dependent, gamma subunit 3
chr9_+_104569754 6.144 ENSMUST00000077190.6
Cpne4
copine IV
chr4_-_129121234 5.916 ENSMUST00000030572.3
Hpca
hippocalcin
chr19_+_22139028 5.862 ENSMUST00000099569.2
ENSMUST00000087576.4
ENSMUST00000074770.5
Trpm3


transient receptor potential cation channel, subfamily M, member 3


chr15_-_76722161 5.442 ENSMUST00000049956.4
Lrrc24
leucine rich repeat containing 24
chr16_-_37384915 5.391 ENSMUST00000114787.1
ENSMUST00000114782.1
ENSMUST00000023526.2
ENSMUST00000114775.1
Stxbp5l



syntaxin binding protein 5-like



chr13_-_56895737 5.252 ENSMUST00000022023.6
ENSMUST00000109871.1
Trpc7

transient receptor potential cation channel, subfamily C, member 7

chr1_+_81077204 5.083 ENSMUST00000123720.1
Nyap2
neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2
chr4_+_129136948 4.877 ENSMUST00000102600.3
Fndc5
fibronectin type III domain containing 5
chr1_-_193035651 4.801 ENSMUST00000016344.7
Syt14
synaptotagmin XIV
chr5_-_116591811 4.788 ENSMUST00000076124.5
Srrm4
serine/arginine repetitive matrix 4
chr17_-_23740301 4.465 ENSMUST00000024702.3
Paqr4
progestin and adipoQ receptor family member IV
chr7_+_122671378 4.226 ENSMUST00000182563.1
Cacng3
calcium channel, voltage-dependent, gamma subunit 3
chr6_+_113282302 4.127 ENSMUST00000041203.5
Cpne9
copine family member IX
chr19_-_45046614 3.801 ENSMUST00000145391.1
Pdzd7
PDZ domain containing 7
chr6_+_8948608 3.796 ENSMUST00000160300.1
Nxph1
neurexophilin 1
chr12_+_102554966 3.721 ENSMUST00000021610.5
Chga
chromogranin A
chr2_-_28916412 3.610 ENSMUST00000050776.2
ENSMUST00000113849.1
Barhl1

BarH-like 1 (Drosophila)

chr15_-_11037968 3.459 ENSMUST00000058007.5
Rxfp3
relaxin family peptide receptor 3
chr4_-_153482768 3.270 ENSMUST00000105646.2
Ajap1
adherens junction associated protein 1
chr16_-_37384940 3.123 ENSMUST00000114781.1
ENSMUST00000114780.1
Stxbp5l

syntaxin binding protein 5-like

chr11_+_102393403 2.995 ENSMUST00000107105.2
ENSMUST00000107102.1
ENSMUST00000107103.1
ENSMUST00000006750.7
Rundc3a



RUN domain containing 3A



chr13_+_54371340 2.868 ENSMUST00000026985.8
Cplx2
complexin 2
chr1_-_34579613 2.760 ENSMUST00000062557.3
1700101I19Rik
RIKEN cDNA 1700101I19 gene
chr9_-_63146980 2.699 ENSMUST00000055281.7
ENSMUST00000119146.1
Skor1

SKI family transcriptional corepressor 1

chr8_+_18846251 2.571 ENSMUST00000149565.1
ENSMUST00000033847.4
Agpat5

1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)

chr2_+_152143552 2.558 ENSMUST00000089112.5
Tcf15
transcription factor 15
chr13_-_105054895 2.533 ENSMUST00000063551.5
Rgs7bp
regulator of G-protein signalling 7 binding protein
chr7_+_63444741 2.472 ENSMUST00000058476.7
Otud7a
OTU domain containing 7A
chr9_-_22085391 2.399 ENSMUST00000179422.1
ENSMUST00000098937.3
ENSMUST00000177967.1
ENSMUST00000180180.1
Ecsit



ECSIT homolog (Drosophila)



chr12_-_84698769 2.274 ENSMUST00000095550.2
Syndig1l
synapse differentiation inducing 1 like
chr11_+_77930800 2.177 ENSMUST00000093995.3
ENSMUST00000000646.7
Sez6

seizure related gene 6

chr2_-_28916668 2.155 ENSMUST00000113847.1
Barhl1
BarH-like 1 (Drosophila)
chr9_+_122117375 2.100 ENSMUST00000118886.1
Snrk
SNF related kinase
chr9_+_122117258 1.850 ENSMUST00000146832.1
ENSMUST00000139181.1
Snrk

SNF related kinase

chr17_-_83631892 1.787 ENSMUST00000051482.1
Kcng3
potassium voltage-gated channel, subfamily G, member 3
chr8_+_69088646 1.480 ENSMUST00000006435.7
Atp6v1b2
ATPase, H+ transporting, lysosomal V1 subunit B2
chr15_-_75747922 1.427 ENSMUST00000062002.4
Mafa
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian)
chr9_+_122117338 1.401 ENSMUST00000120173.1
ENSMUST00000134949.1
ENSMUST00000119215.1
Snrk


SNF related kinase


chr12_+_119945957 1.291 ENSMUST00000058644.8
Tmem196
transmembrane protein 196
chr7_+_51621830 1.170 ENSMUST00000032710.5
Slc17a6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr12_+_113140198 1.135 ENSMUST00000084882.4
Crip2
cysteine rich protein 2
chr13_-_23991158 0.793 ENSMUST00000021770.7
Scgn
secretagogin, EF-hand calcium binding protein
chr11_-_117873433 0.648 ENSMUST00000033230.7
Tha1
threonine aldolase 1
chr6_-_134887783 0.636 ENSMUST00000066107.6
Gpr19
G protein-coupled receptor 19
chr19_+_5038826 0.567 ENSMUST00000053705.6
B3gnt1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
chr5_+_38260372 0.472 ENSMUST00000119047.1
Tmem128
transmembrane protein 128
chr9_+_40873981 0.449 ENSMUST00000067375.3
Bsx
brain specific homeobox
chr10_+_90829538 0.374 ENSMUST00000179694.2
Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr2_-_92401237 0.306 ENSMUST00000050312.2
Mapk8ip1
mitogen-activated protein kinase 8 interacting protein 1
chr1_-_162548484 0.091 ENSMUST00000028017.9
Mettl13
methyltransferase like 13
chr10_+_90829409 0.039 ENSMUST00000182202.1
ENSMUST00000182966.1
Anks1b

ankyrin repeat and sterile alpha motif domain containing 1B


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
8.1 32.3 GO:0021586 pons maturation(GO:0021586)
4.3 38.9 GO:0060373 regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371) regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
3.3 13.1 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
2.9 32.0 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
2.6 13.1 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
2.4 21.9 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
2.4 7.2 GO:0060084 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) synaptic transmission involved in micturition(GO:0060084)
2.1 6.3 GO:0038003 opioid receptor signaling pathway(GO:0038003) regulation of opioid receptor signaling pathway(GO:2000474)
2.0 5.9 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
1.8 10.9 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
1.8 7.2 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
1.6 16.4 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
1.6 9.5 GO:0072318 clathrin coat disassembly(GO:0072318)
1.2 3.7 GO:1901079 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738) positive regulation of relaxation of muscle(GO:1901079)
1.2 7.3 GO:0036515 serotonergic neuron axon guidance(GO:0036515)
1.0 10.2 GO:0048149 behavioral response to ethanol(GO:0048149)
1.0 25.5 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.8 3.3 GO:0030860 regulation of polarized epithelial cell differentiation(GO:0030860)
0.8 12.0 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.7 16.3 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.6 4.9 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.6 6.3 GO:0044331 cell-cell adhesion mediated by cadherin(GO:0044331)
0.6 6.7 GO:0043084 penile erection(GO:0043084)
0.5 10.4 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.5 2.5 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.5 7.4 GO:0007220 Notch receptor processing(GO:0007220)
0.5 8.3 GO:0097091 synaptic vesicle clustering(GO:0097091)
0.5 16.3 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.5 6.9 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.4 9.7 GO:0071625 vocalization behavior(GO:0071625)
0.4 2.6 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.4 10.2 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.3 4.1 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.3 2.9 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
0.2 5.3 GO:0006828 manganese ion transport(GO:0006828)
0.2 0.6 GO:0006566 threonine metabolic process(GO:0006566)
0.2 3.0 GO:0030828 positive regulation of cGMP biosynthetic process(GO:0030828)
0.2 8.5 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.2 3.5 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.2 8.5 GO:2001222 regulation of neuron migration(GO:2001222)
0.1 1.2 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.1 2.2 GO:0060074 synapse maturation(GO:0060074)
0.1 1.4 GO:0007263 nitric oxide mediated signal transduction(GO:0007263)
0.1 11.8 GO:0014065 phosphatidylinositol 3-kinase signaling(GO:0014065)
0.1 10.6 GO:0007605 sensory perception of sound(GO:0007605)
0.1 5.4 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 8.4 GO:0007286 spermatid development(GO:0007286)
0.1 0.4 GO:0060056 mammary gland involution(GO:0060056)
0.1 0.3 GO:0007258 JUN phosphorylation(GO:0007258)
0.1 1.5 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.0 2.4 GO:0051341 regulation of oxidoreductase activity(GO:0051341)
0.0 2.7 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.0 9.0 GO:0060828 regulation of canonical Wnt signaling pathway(GO:0060828)
0.0 4.8 GO:0006906 vesicle fusion(GO:0006906)
0.0 0.4 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.0 2.6 GO:0006639 neutral lipid metabolic process(GO:0006638) acylglycerol metabolic process(GO:0006639)
0.0 1.8 GO:0071805 potassium ion transmembrane transport(GO:0071805)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
5.5 21.9 GO:0044307 dendritic branch(GO:0044307)
3.5 10.4 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
2.7 32.0 GO:0002178 palmitoyltransferase complex(GO:0002178)
2.6 38.9 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
1.9 13.1 GO:0031428 box C/D snoRNP complex(GO:0031428)
1.8 10.9 GO:0008091 spectrin(GO:0008091)
1.5 13.1 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
1.4 16.7 GO:0044294 dendritic growth cone(GO:0044294)
1.3 16.3 GO:0030123 AP-3 adaptor complex(GO:0030123)
1.0 3.8 GO:0002141 stereocilia ankle link(GO:0002141)
0.8 8.2 GO:0032426 stereocilium tip(GO:0032426)
0.8 3.3 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.7 3.7 GO:0042583 chromaffin granule(GO:0042583)
0.7 2.9 GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.7 10.5 GO:0097449 astrocyte projection(GO:0097449)
0.7 7.2 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.6 5.9 GO:0044327 dendritic spine head(GO:0044327)
0.5 24.6 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.5 9.4 GO:0032279 asymmetric synapse(GO:0032279)
0.4 11.5 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.3 7.4 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.3 9.3 GO:0060077 inhibitory synapse(GO:0060077)
0.3 10.4 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.3 10.6 GO:0097440 apical dendrite(GO:0097440)
0.2 1.5 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 6.7 GO:0030667 secretory granule membrane(GO:0030667)
0.1 5.3 GO:0005801 cis-Golgi network(GO:0005801)
0.1 11.4 GO:0008021 synaptic vesicle(GO:0008021)
0.1 10.3 GO:0030141 secretory granule(GO:0030141)
0.0 7.4 GO:0005769 early endosome(GO:0005769)
0.0 9.8 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 4.9 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 1.8 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 18.4 GO:0042995 cell projection(GO:0042995)
0.0 6.6 GO:0005667 transcription factor complex(GO:0005667)
0.0 1.1 GO:0099568 cytoplasmic region(GO:0099568)
0.0 7.2 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 8.5 GO:0016604 nuclear body(GO:0016604)
0.0 9.4 GO:0005886 plasma membrane(GO:0005886)
0.0 37.4 GO:0016021 integral component of membrane(GO:0016021)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
5.6 38.9 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
3.6 21.9 GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
2.7 16.4 GO:0033691 sialic acid binding(GO:0033691)
2.6 10.5 GO:0030348 syntaxin-3 binding(GO:0030348)
2.0 10.2 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
1.6 16.3 GO:0042301 phosphate ion binding(GO:0042301)
1.1 32.0 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
1.1 13.1 GO:0097109 neuroligin family protein binding(GO:0097109)
1.0 3.0 GO:0030249 guanylate cyclase regulator activity(GO:0030249)
0.9 3.5 GO:0004966 galanin receptor activity(GO:0004966)
0.9 25.5 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.8 13.1 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.7 7.2 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.4 5.3 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.4 9.1 GO:0017075 syntaxin-1 binding(GO:0017075)
0.3 10.4 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.3 6.2 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.3 10.4 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.2 0.6 GO:0008732 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.2 24.7 GO:0000149 SNARE binding(GO:0000149)
0.2 7.4 GO:0005112 Notch binding(GO:0005112)
0.2 10.9 GO:0030507 spectrin binding(GO:0030507)
0.2 11.2 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.2 8.4 GO:0015485 cholesterol binding(GO:0015485)
0.1 18.7 GO:0051219 phosphoprotein binding(GO:0051219)
0.1 8.3 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 2.6 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 1.8 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 2.5 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.1 10.3 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 6.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 1.2 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.0 5.9 GO:0005261 cation channel activity(GO:0005261)
0.0 2.4 GO:0016651 oxidoreductase activity, acting on NAD(P)H(GO:0016651)
0.0 3.3 GO:0008013 beta-catenin binding(GO:0008013)
0.0 2.7 GO:0046332 SMAD binding(GO:0046332)
0.0 10.2 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 5.4 GO:0000287 magnesium ion binding(GO:0000287)
0.0 5.7 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 0.3 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 4.8 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 3.5 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.0 8.5 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.0 5.9 GO:0003779 actin binding(GO:0003779)
0.0 1.5 GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820)
0.0 0.4 GO:0046875 ephrin receptor binding(GO:0046875)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 16.4 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.3 38.9 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.2 10.2 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.2 10.4 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 7.4 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 6.3 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 66.2 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
1.2 32.1 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.9 7.2 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.9 5.3 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.6 8.3 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.5 10.4 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.4 6.3 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.3 10.4 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.3 9.5 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.2 7.4 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 2.6 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.1 1.5 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.1 1.4 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 1.8 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 11.4 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 2.4 REACTOME_TRAF6_MEDIATED_INDUCTION_OF_NFKB_AND_MAP_KINASES_UPON_TLR7_8_OR_9_ACTIVATION Genes involved in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
0.0 0.6 REACTOME_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.0 1.2 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters