Motif ID: Rhox4e_Rhox6_Vax2

Z-value: 1.084

Transcription factors associated with Rhox4e_Rhox6_Vax2:

Gene SymbolEntrez IDGene Name
Rhox4e ENSMUSG00000071770.4 Rhox4e
Rhox6 ENSMUSG00000006200.3 Rhox6
Vax2 ENSMUSG00000034777.1 Vax2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Vax2mm10_v2_chr6_+_83711232_83711288-0.241.4e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Rhox4e_Rhox6_Vax2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_23248264 23.325 ENSMUST00000031709.5
Fezf1
Fez family zinc finger 1
chrX_-_60893430 8.367 ENSMUST00000135107.2
Sox3
SRY-box containing gene 3
chr8_+_45658666 5.889 ENSMUST00000134675.1
ENSMUST00000139869.1
ENSMUST00000126067.1
Sorbs2


sorbin and SH3 domain containing 2


chr8_+_45658731 5.735 ENSMUST00000143820.1
ENSMUST00000132139.1
Sorbs2

sorbin and SH3 domain containing 2

chr4_+_15881255 4.803 ENSMUST00000029876.1
Calb1
calbindin 1
chr15_-_67113909 4.638 ENSMUST00000092640.5
St3gal1
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr1_-_89933290 4.559 ENSMUST00000036954.7
Gbx2
gastrulation brain homeobox 2
chr3_+_55782500 4.499 ENSMUST00000075422.4
Mab21l1
mab-21-like 1 (C. elegans)
chr13_-_102906046 3.908 ENSMUST00000171791.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr7_-_25005895 3.824 ENSMUST00000102858.3
ENSMUST00000080882.6
Atp1a3

ATPase, Na+/K+ transporting, alpha 3 polypeptide

chr9_+_53771499 3.486 ENSMUST00000048670.8
Slc35f2
solute carrier family 35, member F2
chr13_-_102905740 3.357 ENSMUST00000167462.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr12_-_112511136 3.352 ENSMUST00000066791.5
Tmem179
transmembrane protein 179
chr9_+_102720287 3.031 ENSMUST00000130602.1
Amotl2
angiomotin-like 2
chr16_-_42340595 2.985 ENSMUST00000102817.4
Gap43
growth associated protein 43
chr14_+_5517172 2.940 ENSMUST00000178220.1
Gm3488
predicted gene, 3488
chr14_+_5164535 2.940 ENSMUST00000179659.1
Gm3317
predicted gene 3317
chr3_-_86548268 2.849 ENSMUST00000077524.3
Mab21l2
mab-21-like 2 (C. elegans)
chr8_+_45507768 2.676 ENSMUST00000067065.7
ENSMUST00000098788.3
ENSMUST00000067107.7
ENSMUST00000171337.2
ENSMUST00000138049.1
ENSMUST00000141039.1
Sorbs2





sorbin and SH3 domain containing 2





chr12_+_109545390 2.636 ENSMUST00000146701.1
Meg3
maternally expressed 3
chr12_-_40037387 2.531 ENSMUST00000146905.1
Arl4a
ADP-ribosylation factor-like 4A
chr14_+_3667518 2.500 ENSMUST00000112801.3
Gm3020
predicted gene 3020
chr14_-_6411578 2.445 ENSMUST00000179312.1
Gm3591
predicted gene 3591
chr1_+_109983737 2.373 ENSMUST00000172005.1
Cdh7
cadherin 7, type 2
chrX_-_23266751 2.371 ENSMUST00000115316.2
Klhl13
kelch-like 13
chr2_-_168767136 2.292 ENSMUST00000029061.5
ENSMUST00000103074.1
Sall4

sal-like 4 (Drosophila)

chr1_+_72284367 2.257 ENSMUST00000027380.5
ENSMUST00000141783.1
Tmem169

transmembrane protein 169

chr14_+_4514758 2.249 ENSMUST00000112776.2
Gm3173
predicted gene 3173
chr14_-_7473073 2.245 ENSMUST00000167833.2
Gm3752
predicted gene 3752
chr14_+_4198185 2.235 ENSMUST00000180184.1
Gm2974
predicted gene 2974
chr14_-_6874257 2.205 ENSMUST00000178298.1
ENSMUST00000179374.1
Gm3667
Gm3629
predicted gene 3667
predicted gene 3629
chr2_+_25372315 2.203 ENSMUST00000028329.6
ENSMUST00000114293.2
ENSMUST00000100323.2
Sapcd2


suppressor APC domain containing 2


chr14_+_3348089 2.188 ENSMUST00000178722.1
Gm2956
predicted gene 2956
chrM_+_7759 2.176 ENSMUST00000082407.1
ENSMUST00000082408.1
mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr14_+_3428103 2.132 ENSMUST00000178060.1
Gm3005
predicted gene 3005
chr14_+_4741737 2.115 ENSMUST00000178748.1
Gm3252
predicted gene 3252
chr10_-_33951190 2.112 ENSMUST00000048222.4
Zufsp
zinc finger with UFM1-specific peptidase domain
chr14_-_5863663 2.043 ENSMUST00000178594.1
Gm8237
predicted gene 8237
chr14_+_4871156 2.013 ENSMUST00000166410.2
Gm3264
predicted gene 3264
chr3_+_40800778 2.002 ENSMUST00000169566.1
Plk4
polo-like kinase 4
chr14_+_4430992 1.983 ENSMUST00000164603.1
ENSMUST00000166848.1
Gm3173

predicted gene 3173

chr14_+_4126066 1.974 ENSMUST00000167397.2
Gm8108
predicted gene 8108
chr14_-_19569553 1.885 ENSMUST00000112595.2
Gm2237
predicted gene 2237
chr8_-_61902669 1.861 ENSMUST00000121785.1
ENSMUST00000034057.7
Palld

palladin, cytoskeletal associated protein

chr14_-_6741430 1.853 ENSMUST00000100904.4
Gm3636
predicted gene 3636
chr2_+_65845767 1.829 ENSMUST00000122912.1
Csrnp3
cysteine-serine-rich nuclear protein 3
chr14_+_3825596 1.825 ENSMUST00000178256.1
Gm3002
predicted gene 3002
chr10_-_8886033 1.802 ENSMUST00000015449.5
Sash1
SAM and SH3 domain containing 1
chr14_-_6266620 1.782 ENSMUST00000096172.5
Gm3411
predicted gene 3411
chr14_+_4665094 1.661 ENSMUST00000169675.2
Gm3239
predicted gene 3239
chr2_-_168767029 1.616 ENSMUST00000075044.3
Sall4
sal-like 4 (Drosophila)
chr9_+_119063429 1.564 ENSMUST00000141185.1
ENSMUST00000126251.1
ENSMUST00000136561.1
Vill


villin-like


chr4_-_129227883 1.543 ENSMUST00000106051.1
C77080
expressed sequence C77080
chrX_+_9885622 1.529 ENSMUST00000067529.2
ENSMUST00000086165.3
Sytl5

synaptotagmin-like 5

chr4_-_43499608 1.416 ENSMUST00000136005.1
ENSMUST00000054538.6
Arhgef39

Rho guanine nucleotide exchange factor (GEF) 39

chr19_+_23723279 1.408 ENSMUST00000067077.1
Gm9938
predicted gene 9938
chr13_-_53473074 1.346 ENSMUST00000021922.8
Msx2
msh homeobox 2
chr2_+_125136692 1.341 ENSMUST00000099452.2
Ctxn2
cortexin 2
chr18_+_4993795 1.323 ENSMUST00000153016.1
Svil
supervillin
chr9_+_108339048 1.210 ENSMUST00000082429.5
Gpx1
glutathione peroxidase 1
chr7_-_29155597 1.182 ENSMUST00000123416.1
Fam98c
family with sequence similarity 98, member C
chr6_+_37870786 1.127 ENSMUST00000120428.1
ENSMUST00000031859.7
Trim24

tripartite motif-containing 24

chrX_+_150589907 1.091 ENSMUST00000080884.4
Pfkfb1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr3_-_67515487 1.075 ENSMUST00000178314.1
ENSMUST00000054825.4
Rarres1

retinoic acid receptor responder (tazarotene induced) 1

chr7_-_29155717 1.067 ENSMUST00000153251.1
Fam98c
family with sequence similarity 98, member C
chrM_+_7005 1.038 ENSMUST00000082405.1
mt-Co2
mitochondrially encoded cytochrome c oxidase II
chr9_+_72806874 1.033 ENSMUST00000055535.8
Prtg
protogenin homolog (Gallus gallus)
chr7_+_38183217 1.033 ENSMUST00000165308.1
1600014C10Rik
RIKEN cDNA 1600014C10 gene
chr17_-_48432723 1.019 ENSMUST00000046549.3
Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr3_+_55461758 1.015 ENSMUST00000070418.4
Dclk1
doublecortin-like kinase 1
chrM_+_8600 1.014 ENSMUST00000082409.1
mt-Co3
mitochondrially encoded cytochrome c oxidase III
chr17_-_15527281 0.993 ENSMUST00000154293.1
ENSMUST00000054450.6
Pdcd2

programmed cell death 2

chr5_+_135994796 0.973 ENSMUST00000111142.2
ENSMUST00000111145.3
ENSMUST00000111144.1
ENSMUST00000005072.3
ENSMUST00000130345.1
Dtx2




deltex 2 homolog (Drosophila)




chr15_+_59315088 0.944 ENSMUST00000100640.4
Sqle
squalene epoxidase
chr2_+_65845833 0.929 ENSMUST00000053910.3
Csrnp3
cysteine-serine-rich nuclear protein 3
chr11_+_58171648 0.920 ENSMUST00000020820.1
Mrpl22
mitochondrial ribosomal protein L22
chr2_-_144270852 0.897 ENSMUST00000110030.3
Snx5
sorting nexin 5
chr16_+_58408443 0.858 ENSMUST00000046663.7
Dcbld2
discoidin, CUB and LCCL domain containing 2
chr13_+_23533869 0.776 ENSMUST00000073261.2
Hist1h2af
histone cluster 1, H2af
chr2_-_121235689 0.764 ENSMUST00000142400.1
Trp53bp1
transformation related protein 53 binding protein 1
chr10_-_61784014 0.748 ENSMUST00000020283.4
H2afy2
H2A histone family, member Y2
chr16_-_55283237 0.738 ENSMUST00000036412.3
Zpld1
zona pellucida like domain containing 1
chr5_-_136986829 0.718 ENSMUST00000034953.7
ENSMUST00000085941.5
Znhit1

zinc finger, HIT domain containing 1

chr8_+_107031218 0.707 ENSMUST00000034388.9
Vps4a
vacuolar protein sorting 4a (yeast)
chr2_+_65620829 0.695 ENSMUST00000028377.7
Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr13_+_90089705 0.691 ENSMUST00000012566.8
Tmem167
transmembrane protein 167
chr6_-_124779686 0.678 ENSMUST00000147669.1
ENSMUST00000128697.1
ENSMUST00000032218.3
ENSMUST00000112475.2
Lrrc23



leucine rich repeat containing 23



chr18_+_4920509 0.677 ENSMUST00000126977.1
Svil
supervillin
chr9_-_55919605 0.651 ENSMUST00000037408.8
Scaper
S phase cyclin A-associated protein in the ER
chr2_+_69897220 0.647 ENSMUST00000055758.9
ENSMUST00000112251.2
Ubr3

ubiquitin protein ligase E3 component n-recognin 3

chr19_+_25406661 0.640 ENSMUST00000146647.1
Kank1
KN motif and ankyrin repeat domains 1
chr1_-_135284075 0.630 ENSMUST00000077340.7
ENSMUST00000074357.7
Rnpep

arginyl aminopeptidase (aminopeptidase B)

chr9_-_112187766 0.620 ENSMUST00000111872.2
ENSMUST00000164754.2
Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr15_+_59315030 0.610 ENSMUST00000022977.7
Sqle
squalene epoxidase
chr17_-_59013264 0.605 ENSMUST00000174122.1
ENSMUST00000025065.5
Nudt12

nudix (nucleoside diphosphate linked moiety X)-type motif 12

chrM_+_2743 0.603 ENSMUST00000082392.1
mt-Nd1
mitochondrially encoded NADH dehydrogenase 1
chr2_-_71367749 0.589 ENSMUST00000151937.1
Slc25a12
solute carrier family 25 (mitochondrial carrier, Aralar), member 12
chr12_+_100110148 0.574 ENSMUST00000021595.8
Psmc1
protease (prosome, macropain) 26S subunit, ATPase 1
chr18_-_56975333 0.570 ENSMUST00000139243.2
ENSMUST00000025488.8
C330018D20Rik

RIKEN cDNA C330018D20 gene

chr2_-_150255591 0.568 ENSMUST00000063463.5
Gm21994
predicted gene 21994
chr11_+_69838514 0.566 ENSMUST00000133967.1
ENSMUST00000094065.4
Tmem256

transmembrane protein 256

chr5_+_138187485 0.515 ENSMUST00000110934.2
Cnpy4
canopy 4 homolog (zebrafish)
chr3_-_10440054 0.509 ENSMUST00000099223.4
ENSMUST00000029047.6
Snx16

sorting nexin 16

chr14_-_20496780 0.499 ENSMUST00000022353.3
Mss51
MSS51 mitochondrial translational activator
chr12_+_52699297 0.496 ENSMUST00000095737.3
Akap6
A kinase (PRKA) anchor protein 6
chr1_-_172027269 0.489 ENSMUST00000027837.6
ENSMUST00000111264.1
Vangl2

vang-like 2 (van gogh, Drosophila)

chr17_+_27839974 0.482 ENSMUST00000071006.7
Snrpc
U1 small nuclear ribonucleoprotein C
chr2_-_132247747 0.480 ENSMUST00000110163.1
ENSMUST00000180286.1
ENSMUST00000028816.2
Tmem230


transmembrane protein 230


chr11_-_99230998 0.475 ENSMUST00000103133.3
Smarce1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
chr14_+_3224440 0.453 ENSMUST00000112797.4
D830030K20Rik
RIKEN cDNA D830030K20 gene
chr12_-_84617326 0.449 ENSMUST00000021666.4
Abcd4
ATP-binding cassette, sub-family D (ALD), member 4
chr2_-_69712461 0.444 ENSMUST00000102706.3
ENSMUST00000073152.6
Fastkd1

FAST kinase domains 1

chr3_-_90389884 0.435 ENSMUST00000029541.5
Slc27a3
solute carrier family 27 (fatty acid transporter), member 3
chr10_+_128337761 0.429 ENSMUST00000005826.7
Cs
citrate synthase
chr5_-_134946917 0.425 ENSMUST00000051401.2
Cldn4
claudin 4
chr4_-_14621669 0.411 ENSMUST00000143105.1
Slc26a7
solute carrier family 26, member 7
chr15_-_36794498 0.410 ENSMUST00000110361.1
ENSMUST00000022894.7
ENSMUST00000110359.1
Ywhaz


tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide


chr12_+_10390756 0.407 ENSMUST00000020947.5
Rdh14
retinol dehydrogenase 14 (all-trans and 9-cis)
chr3_+_103575275 0.406 ENSMUST00000090697.4
Syt6
synaptotagmin VI
chr12_-_80643799 0.402 ENSMUST00000166931.1
Erh
enhancer of rudimentary homolog (Drosophila)
chr3_+_122274371 0.386 ENSMUST00000035776.8
Dnttip2
deoxynucleotidyltransferase, terminal, interacting protein 2
chr14_+_3846245 0.381 ENSMUST00000180934.1
Gm3033
predicted gene 3033
chr9_+_123366921 0.378 ENSMUST00000038863.7
Lars2
leucyl-tRNA synthetase, mitochondrial
chr17_-_55915870 0.336 ENSMUST00000074828.4
Rpl21-ps6
ribosomal protein L21, pseudogene 6
chr4_+_100478806 0.333 ENSMUST00000133493.2
ENSMUST00000092730.3
ENSMUST00000106979.3
Ube2u


ubiquitin-conjugating enzyme E2U (putative)


chr10_-_77166545 0.307 ENSMUST00000081654.6
Col18a1
collagen, type XVIII, alpha 1
chr1_+_87183310 0.300 ENSMUST00000044533.8
Prss56
protease, serine 56
chr2_-_155074447 0.296 ENSMUST00000137242.1
ENSMUST00000054607.9
Ahcy

S-adenosylhomocysteine hydrolase

chr9_-_62510498 0.294 ENSMUST00000164246.2
Coro2b
coronin, actin binding protein, 2B
chr3_+_103575231 0.291 ENSMUST00000121834.1
Syt6
synaptotagmin VI
chr18_+_59062282 0.287 ENSMUST00000165666.2
A730017C20Rik
RIKEN cDNA A730017C20 gene
chr13_-_66852017 0.285 ENSMUST00000059329.6
Gm17449
predicted gene, 17449
chr4_-_132075250 0.283 ENSMUST00000105970.1
ENSMUST00000105975.1
Epb4.1

erythrocyte protein band 4.1

chrX_-_143933204 0.281 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
Dcx


doublecortin


chr7_+_128744870 0.277 ENSMUST00000042942.8
Sec23ip
Sec23 interacting protein
chrX_+_101429555 0.276 ENSMUST00000033673.6
Nono
non-POU-domain-containing, octamer binding protein
chr7_+_12927410 0.269 ENSMUST00000045870.4
2310014L17Rik
RIKEN cDNA 2310014L17 gene
chr13_+_67833235 0.269 ENSMUST00000060609.7
Gm10037
predicted gene 10037
chr5_-_17888884 0.262 ENSMUST00000169095.1
Cd36
CD36 antigen
chr5_-_137531952 0.257 ENSMUST00000140139.1
Gnb2
guanine nucleotide binding protein (G protein), beta 2
chr2_+_155751117 0.257 ENSMUST00000029140.5
ENSMUST00000132608.1
Procr

protein C receptor, endothelial

chr2_+_174450678 0.242 ENSMUST00000016399.5
Tubb1
tubulin, beta 1 class VI
chr9_-_71163224 0.241 ENSMUST00000074465.2
Aqp9
aquaporin 9
chr7_+_126950687 0.238 ENSMUST00000106333.1
Sez6l2
seizure related 6 homolog like 2
chr8_-_54724317 0.237 ENSMUST00000129132.2
ENSMUST00000150488.1
ENSMUST00000127511.2
Wdr17


WD repeat domain 17


chr2_+_119047129 0.227 ENSMUST00000153300.1
ENSMUST00000028799.5
Casc5

cancer susceptibility candidate 5

chr9_-_99568849 0.216 ENSMUST00000035043.5
Armc8
armadillo repeat containing 8
chr13_+_59585259 0.213 ENSMUST00000168367.1
ENSMUST00000022038.7
ENSMUST00000166923.1
Naa35


N(alpha)-acetyltransferase 35, NatC auxiliary subunit


chr12_-_55302974 0.205 ENSMUST00000021410.8
Ppp2r3c
protein phosphatase 2, regulatory subunit B'', gamma
chr2_-_106002008 0.202 ENSMUST00000155811.1
Dnajc24
DnaJ (Hsp40) homolog, subfamily C, member 24
chr14_-_7450917 0.196 ENSMUST00000169555.1
Gm3755
predicted gene 3755
chrX_-_101086020 0.186 ENSMUST00000113710.1
Slc7a3
solute carrier family 7 (cationic amino acid transporter, y+ system), member 3
chr19_-_11604828 0.174 ENSMUST00000025582.4
Ms4a6d
membrane-spanning 4-domains, subfamily A, member 6D
chr18_+_60212080 0.169 ENSMUST00000031549.5
Gm4951
predicted gene 4951
chrX_-_160138375 0.168 ENSMUST00000033662.8
Pdha1
pyruvate dehydrogenase E1 alpha 1
chr11_-_4095344 0.166 ENSMUST00000004868.5
Mtfp1
mitochondrial fission process 1
chr18_+_59062462 0.154 ENSMUST00000058633.2
ENSMUST00000175897.1
ENSMUST00000118510.1
ENSMUST00000175830.1
A730017C20Rik



RIKEN cDNA A730017C20 gene



chr5_+_3543812 0.152 ENSMUST00000115527.3
Fam133b
family with sequence similarity 133, member B
chr13_-_92030897 0.147 ENSMUST00000149630.1
Rasgrf2
RAS protein-specific guanine nucleotide-releasing factor 2
chr5_+_29195983 0.145 ENSMUST00000160888.1
ENSMUST00000159272.1
ENSMUST00000001247.5
ENSMUST00000161398.1
ENSMUST00000160246.1
Rnf32




ring finger protein 32




chr5_-_118244861 0.144 ENSMUST00000117177.1
ENSMUST00000133372.1
ENSMUST00000154786.1
ENSMUST00000121369.1
Rnft2



ring finger protein, transmembrane 2



chr9_+_40801235 0.142 ENSMUST00000117870.1
ENSMUST00000117557.1
Hspa8

heat shock protein 8

chr7_+_57387304 0.142 ENSMUST00000085241.5
Gm9962
predicted gene 9962
chrM_+_14138 0.140 ENSMUST00000082421.1
mt-Cytb
mitochondrially encoded cytochrome b
chr11_+_115564434 0.138 ENSMUST00000021085.4
Nup85
nucleoporin 85
chrM_+_10167 0.137 ENSMUST00000082414.1
mt-Nd4
mitochondrially encoded NADH dehydrogenase 4
chr10_-_88605017 0.129 ENSMUST00000119185.1
ENSMUST00000121629.1
Mybpc1

myosin binding protein C, slow-type

chr19_+_41933464 0.128 ENSMUST00000026154.7
Zdhhc16
zinc finger, DHHC domain containing 16
chr6_+_83165920 0.126 ENSMUST00000077407.5
ENSMUST00000113913.1
ENSMUST00000130212.1
Dctn1


dynactin 1


chr19_+_60811574 0.113 ENSMUST00000128357.1
ENSMUST00000119633.1
ENSMUST00000025957.8
Fam45a


family with sequence similarity 45, member A


chr5_-_137531204 0.077 ENSMUST00000150063.2
Gnb2
guanine nucleotide binding protein (G protein), beta 2
chr5_-_34660068 0.076 ENSMUST00000041364.9
Nop14
NOP14 nucleolar protein
chr18_-_10706688 0.062 ENSMUST00000002549.7
ENSMUST00000117726.1
ENSMUST00000117828.1
Abhd3


abhydrolase domain containing 3


chr2_-_125782834 0.061 ENSMUST00000053699.6
Secisbp2l
SECIS binding protein 2-like
chr8_-_84662841 0.041 ENSMUST00000060427.4
Ier2
immediate early response 2
chr14_+_99099433 0.031 ENSMUST00000022650.7
Pibf1
progesterone immunomodulatory binding factor 1
chr18_+_55057557 0.030 ENSMUST00000181765.1
Gm4221
predicted gene 4221
chr18_-_24603791 0.024 ENSMUST00000070726.3
Slc39a6
solute carrier family 39 (metal ion transporter), member 6
chr10_-_76110956 0.023 ENSMUST00000120757.1
Slc5a4b
solute carrier family 5 (neutral amino acid transporters, system A), member 4b
chrX_+_170009892 0.015 ENSMUST00000180251.1
Gm21887
predicted gene, 21887

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 23.3 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.0 4.8 GO:0072235 distal convoluted tubule development(GO:0072025) metanephric distal convoluted tubule development(GO:0072221) metanephric distal tubule development(GO:0072235)
0.7 4.6 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.6 1.8 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.4 1.3 GO:0035880 embryonic nail plate morphogenesis(GO:0035880) positive regulation of catagen(GO:0051795) frontal suture morphogenesis(GO:0060364)
0.4 0.8 GO:0061738 late endosomal microautophagy(GO:0061738)
0.4 8.4 GO:0007530 sex determination(GO:0007530)
0.4 3.8 GO:0036376 sodium ion export from cell(GO:0036376)
0.3 1.0 GO:0016554 cytidine to uridine editing(GO:0016554)
0.3 3.0 GO:0016198 axon choice point recognition(GO:0016198)
0.3 14.8 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.3 2.0 GO:0098535 positive regulation of centriole replication(GO:0046601) de novo centriole assembly(GO:0098535)
0.2 0.7 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.2 3.9 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.2 0.6 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.2 1.1 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.2 0.5 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.2 1.2 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862) protein oxidation(GO:0018158)
0.2 0.6 GO:0006742 NADP catabolic process(GO:0006742) pyridine nucleotide catabolic process(GO:0019364)
0.1 0.6 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.1 1.0 GO:1902035 positive regulation of hematopoietic stem cell proliferation(GO:1902035)
0.1 1.1 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1 0.7 GO:1901837 negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837)
0.1 2.8 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.1 1.9 GO:0003334 keratinocyte development(GO:0003334)
0.1 4.6 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.1 2.6 GO:0008340 determination of adult lifespan(GO:0008340)
0.1 0.7 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.1 0.3 GO:0070543 response to linoleic acid(GO:0070543)
0.1 0.4 GO:0090168 Golgi reassembly(GO:0090168)
0.1 0.4 GO:0009235 cobalamin metabolic process(GO:0009235)
0.1 2.2 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 3.0 GO:0035329 hippo signaling(GO:0035329)
0.1 2.5 GO:0050873 brown fat cell differentiation(GO:0050873)
0.1 0.3 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.1 0.4 GO:0046689 response to mercury ion(GO:0046689)
0.1 0.5 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.1 0.8 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0 1.5 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.6 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.0 1.0 GO:0051560 mitochondrial calcium ion homeostasis(GO:0051560)
0.0 0.2 GO:0015819 lysine transport(GO:0015819) ornithine transport(GO:0015822)
0.0 0.4 GO:0042572 retinol metabolic process(GO:0042572)
0.0 0.3 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.0 0.9 GO:0006907 pinocytosis(GO:0006907)
0.0 2.6 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.4 GO:0061436 establishment of skin barrier(GO:0061436)
0.0 2.4 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.5 GO:0006337 nucleosome disassembly(GO:0006337)
0.0 0.4 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.0 0.5 GO:0006622 protein targeting to lysosome(GO:0006622)
0.0 0.2 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0 0.6 GO:0033194 response to hydroperoxide(GO:0033194)
0.0 0.1 GO:0031034 myosin filament assembly(GO:0031034) striated muscle myosin thick filament assembly(GO:0071688)
0.0 0.1 GO:0090063 positive regulation of microtubule nucleation(GO:0090063)
0.0 1.6 GO:0022904 respiratory electron transport chain(GO:0022904)
0.0 8.3 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 1.5 GO:0016126 sterol biosynthetic process(GO:0016126)
0.0 0.3 GO:0001675 acrosome assembly(GO:0001675)
0.0 0.6 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.3 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.0 0.6 GO:0051693 actin filament capping(GO:0051693)
0.0 2.4 GO:0000910 cytokinesis(GO:0000910)
0.0 0.2 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.0 0.0 GO:0031392 regulation of prostaglandin biosynthetic process(GO:0031392) regulation of unsaturated fatty acid biosynthetic process(GO:2001279)
0.0 0.2 GO:0051900 regulation of mitochondrial depolarization(GO:0051900)
0.0 0.6 GO:0034605 cellular response to heat(GO:0034605)
0.0 1.6 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 0.2 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.8 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.4 1.1 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.3 2.0 GO:0098536 deuterosome(GO:0098536)
0.2 2.2 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.2 1.4 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.2 1.1 GO:0005726 perichromatin fibrils(GO:0005726)
0.2 2.2 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.2 1.2 GO:0097413 Lewy body(GO:0097413)
0.1 3.0 GO:0031527 filopodium membrane(GO:0031527)
0.1 0.5 GO:0060187 cell pole(GO:0060187)
0.1 0.7 GO:0001740 Barr body(GO:0001740)
0.1 0.7 GO:0090543 Flemming body(GO:0090543)
0.1 1.0 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 0.2 GO:0031417 NatC complex(GO:0031417)
0.1 0.7 GO:0000812 Swr1 complex(GO:0000812)
0.1 0.6 GO:0031595 nuclear proteasome complex(GO:0031595)
0.1 0.4 GO:0034709 methylosome(GO:0034709)
0.0 0.3 GO:0033503 HULC complex(GO:0033503)
0.0 4.8 GO:0043195 terminal bouton(GO:0043195)
0.0 1.0 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 2.0 GO:0043034 costamere(GO:0043034)
0.0 0.5 GO:0000243 commitment complex(GO:0000243)
0.0 1.9 GO:0002102 podosome(GO:0002102)
0.0 15.9 GO:0014069 postsynaptic density(GO:0014069)
0.0 0.5 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.3 GO:0042382 paraspeckles(GO:0042382)
0.0 3.9 GO:0000792 heterochromatin(GO:0000792)
0.0 2.0 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.5 GO:0071564 npBAF complex(GO:0071564)
0.0 3.4 GO:0005923 bicellular tight junction(GO:0005923)
0.0 0.2 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.8 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.1 GO:0005859 muscle myosin complex(GO:0005859)
0.0 0.9 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.1 GO:0045275 respiratory chain complex III(GO:0045275)
0.0 0.1 GO:0030689 Noc complex(GO:0030689)
0.0 0.8 GO:0000786 nucleosome(GO:0000786)
0.0 0.1 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 2.0 GO:0070382 exocytic vesicle(GO:0070382)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.6 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.4 3.0 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.4 3.8 GO:0008556 sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556)
0.3 1.0 GO:0004126 cytidine deaminase activity(GO:0004126)
0.2 8.2 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.2 1.1 GO:0034056 estrogen response element binding(GO:0034056)
0.2 1.1 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.2 0.6 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.1 0.6 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.1 0.9 GO:0034452 dynactin binding(GO:0034452)
0.1 0.8 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.1 23.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 0.4 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.1 2.1 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.3 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.1 0.6 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.1 4.6 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.1 0.4 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 1.6 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.1 0.2 GO:0015254 glycerol channel activity(GO:0015254)
0.1 4.6 GO:0019842 vitamin binding(GO:0019842)
0.1 0.5 GO:1990446 U1 snRNP binding(GO:1990446)
0.1 0.6 GO:0050897 cobalt ion binding(GO:0050897)
0.1 1.8 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.1 1.2 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 2.2 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.1 GO:0031686 A1 adenosine receptor binding(GO:0031686)
0.0 0.2 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.0 0.3 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.5 GO:0043495 protein anchor(GO:0043495)
0.0 2.3 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 0.1 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.0 0.2 GO:0034604 pyruvate dehydrogenase activity(GO:0004738) oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.0 7.3 GO:0000287 magnesium ion binding(GO:0000287)
0.0 0.4 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.0 3.4 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.0 0.1 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.1 GO:0052740 phosphatidylserine 1-acylhydrolase activity(GO:0052739) 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.0 0.4 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 1.2 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.2 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 1.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 3.3 GO:0003924 GTPase activity(GO:0003924)
0.0 11.2 GO:0019904 protein domain specific binding(GO:0019904)
0.0 0.3 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 1.7 GO:0051015 actin filament binding(GO:0051015)
0.0 0.1 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.1 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 2.4 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.5 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 3.4 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 2.0 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 1.1 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 0.3 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 1.5 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.6 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 1.2 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.1 3.8 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 3.0 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.1 2.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 1.6 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.7 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 1.1 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.2 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.7 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 1.8 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 1.0 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.4 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.2 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.4 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 1.0 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.4 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.0 0.2 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.3 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 3.0 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.3 REACTOME_ANTIGEN_PROCESSING_CROSS_PRESENTATION Genes involved in Antigen processing-Cross presentation
0.0 0.4 REACTOME_CELL_CELL_JUNCTION_ORGANIZATION Genes involved in Cell-cell junction organization
0.0 0.3 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta