Motif ID: Pax4

Z-value: 0.459


Transcription factors associated with Pax4:

Gene SymbolEntrez IDGene Name
Pax4 ENSMUSG00000029706.9 Pax4



Activity profile for motif Pax4.

activity profile for motif Pax4


Sorted Z-values histogram for motif Pax4

Sorted Z-values for motif Pax4



Network of associatons between targets according to the STRING database.



First level regulatory network of Pax4

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_88978958 2.253 ENSMUST00000042594.6
ENSMUST00000109368.1
Mlc1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

chr9_+_32696005 1.783 ENSMUST00000034534.6
ENSMUST00000050797.7
ENSMUST00000184887.1
Ets1


E26 avian leukemia oncogene 1, 5' domain


chr2_+_73271925 1.605 ENSMUST00000090813.5
Sp9
trans-acting transcription factor 9
chr12_-_90738438 1.574 ENSMUST00000082432.3
Dio2
deiodinase, iodothyronine, type II
chrX_+_73192222 1.454 ENSMUST00000101486.4
Xlr3b
X-linked lymphocyte-regulated 3B
chr8_-_84773381 1.249 ENSMUST00000109764.1
Nfix
nuclear factor I/X
chrX_-_73097017 1.154 ENSMUST00000114524.2
ENSMUST00000074619.5
Xlr3a

X-linked lymphocyte-regulated 3A

chr15_-_79164477 1.145 ENSMUST00000040019.4
Sox10
SRY-box containing gene 10
chrX_+_9199865 1.089 ENSMUST00000069763.2
Lancl3
LanC lantibiotic synthetase component C-like 3 (bacterial)
chr18_+_58836721 1.034 ENSMUST00000052907.5
Adamts19
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 19
chr4_-_88033328 1.031 ENSMUST00000078090.5
Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr4_+_136357423 1.018 ENSMUST00000182167.1
Gm17388
predicted gene, 17388
chr13_-_23430826 0.969 ENSMUST00000153753.1
ENSMUST00000141543.1
C230035I16Rik

RIKEN cDNA C230035I16 gene

chr12_+_71048338 0.786 ENSMUST00000135709.1
Arid4a
AT rich interactive domain 4A (RBP1-like)
chr13_-_101768154 0.775 ENSMUST00000055518.6
Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chrX_+_142227923 0.752 ENSMUST00000042329.5
Nxt2
nuclear transport factor 2-like export factor 2
chrX_+_142228177 0.726 ENSMUST00000112914.1
Nxt2
nuclear transport factor 2-like export factor 2
chr12_-_98577940 0.644 ENSMUST00000110113.1
Kcnk10
potassium channel, subfamily K, member 10
chr12_-_80112998 0.640 ENSMUST00000165114.1
ENSMUST00000021552.1
Zfp36l1

zinc finger protein 36, C3H type-like 1

chr11_+_78499087 0.531 ENSMUST00000017488.4
Vtn
vitronectin
chr13_+_75089826 0.530 ENSMUST00000022075.4
Pcsk1
proprotein convertase subtilisin/kexin type 1
chr2_-_125506385 0.499 ENSMUST00000028633.6
Fbn1
fibrillin 1
chr4_+_136284658 0.454 ENSMUST00000144217.1
Zfp46
zinc finger protein 46
chr4_+_147132038 0.432 ENSMUST00000084149.3
Gm13139
predicted gene 13139
chr10_-_62792243 0.430 ENSMUST00000020268.5
Ccar1
cell division cycle and apoptosis regulator 1
chr10_+_119992916 0.429 ENSMUST00000105261.2
Grip1
glutamate receptor interacting protein 1
chr7_+_7171330 0.427 ENSMUST00000051435.7
Zfp418
zinc finger protein 418
chr4_+_136284708 0.427 ENSMUST00000130223.1
Zfp46
zinc finger protein 46
chr1_-_88008520 0.413 ENSMUST00000040783.4
Usp40
ubiquitin specific peptidase 40
chr12_+_33314277 0.400 ENSMUST00000133549.1
Atxn7l1
ataxin 7-like 1
chr9_-_58159201 0.397 ENSMUST00000041477.7
Islr
immunoglobulin superfamily containing leucine-rich repeat
chr2_-_33086366 0.383 ENSMUST00000049618.2
Garnl3
GTPase activating RANGAP domain-like 3
chr13_+_109632760 0.373 ENSMUST00000135275.1
Pde4d
phosphodiesterase 4D, cAMP specific
chr7_-_144738520 0.337 ENSMUST00000118556.2
ENSMUST00000033393.8
Ano1

anoctamin 1, calcium activated chloride channel

chr9_-_103222063 0.337 ENSMUST00000170904.1
Trf
transferrin
chr4_+_146610961 0.333 ENSMUST00000130825.1
Gm13248
predicted gene 13248
chr10_+_90071095 0.330 ENSMUST00000183109.1
Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chrX_-_8206475 0.323 ENSMUST00000089403.3
ENSMUST00000077595.5
ENSMUST00000089402.3
ENSMUST00000082320.5
Porcn



porcupine homolog (Drosophila)



chr5_-_121502980 0.322 ENSMUST00000079368.3
Adam1b
a disintegrin and metallopeptidase domain 1b
chr2_+_158666690 0.320 ENSMUST00000103116.3
Ppp1r16b
protein phosphatase 1, regulatory (inhibitor) subunit 16B
chr2_+_158667119 0.270 ENSMUST00000045503.4
Ppp1r16b
protein phosphatase 1, regulatory (inhibitor) subunit 16B
chr6_+_136518820 0.270 ENSMUST00000032335.6
Atf7ip
activating transcription factor 7 interacting protein
chr5_-_116288978 0.260 ENSMUST00000050178.6
Ccdc60
coiled-coil domain containing 60
chr5_+_124552845 0.249 ENSMUST00000071057.7
Ddx55
DEAD (Asp-Glu-Ala-Asp) box polypeptide 55
chr15_-_50889691 0.247 ENSMUST00000165201.2
ENSMUST00000184458.1
Trps1

trichorhinophalangeal syndrome I (human)

chr4_-_58987095 0.225 ENSMUST00000030069.6
Ptgr1
prostaglandin reductase 1
chr16_+_15637844 0.206 ENSMUST00000023352.8
Prkdc
protein kinase, DNA activated, catalytic polypeptide
chr4_+_150087365 0.194 ENSMUST00000094451.3
Gpr157
G protein-coupled receptor 157
chr5_-_103100054 0.193 ENSMUST00000112848.1
Mapk10
mitogen-activated protein kinase 10
chr12_-_84218835 0.192 ENSMUST00000046266.6
Elmsan1
ELM2 and Myb/SANT-like domain containing 1
chrM_+_11734 0.186 ENSMUST00000082418.1
mt-Nd5
mitochondrially encoded NADH dehydrogenase 5
chr9_-_101198999 0.175 ENSMUST00000066773.7
Ppp2r3a
protein phosphatase 2, regulatory subunit B'', alpha
chr2_-_168741752 0.163 ENSMUST00000029060.4
Atp9a
ATPase, class II, type 9A
chr2_-_168741898 0.157 ENSMUST00000109176.1
ENSMUST00000178504.1
Atp9a

ATPase, class II, type 9A

chr11_+_62574523 0.155 ENSMUST00000018651.7
Trpv2
transient receptor potential cation channel, subfamily V, member 2
chr18_+_53862087 0.151 ENSMUST00000069597.6
Csnk1g3
casein kinase 1, gamma 3
chr5_-_116288944 0.146 ENSMUST00000086483.3
Ccdc60
coiled-coil domain containing 60
chr13_+_38204928 0.138 ENSMUST00000091641.5
ENSMUST00000178564.1
Snrnp48

small nuclear ribonucleoprotein 48 (U11/U12)

chr7_-_45366714 0.117 ENSMUST00000107779.1
Ppfia3
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chrM_+_3906 0.115 ENSMUST00000082396.1
mt-Nd2
mitochondrially encoded NADH dehydrogenase 2
chr7_-_144738478 0.115 ENSMUST00000121758.1
Ano1
anoctamin 1, calcium activated chloride channel
chr15_+_80977765 0.114 ENSMUST00000139517.1
ENSMUST00000042506.8
ENSMUST00000137255.1
Sgsm3


small G protein signaling modulator 3


chr2_-_114654943 0.108 ENSMUST00000028640.7
ENSMUST00000102542.3
Dph6

diphthamine biosynthesis 6

chr1_-_156034800 0.098 ENSMUST00000169241.1
Tor1aip1
torsin A interacting protein 1
chr15_-_50890041 0.081 ENSMUST00000077935.5
Trps1
trichorhinophalangeal syndrome I (human)
chr3_+_95624971 0.078 ENSMUST00000058230.6
ENSMUST00000037983.4
Ensa

endosulfine alpha

chr13_-_66851513 0.070 ENSMUST00000169322.1
Gm17404
predicted gene, 17404
chr2_-_114654861 0.065 ENSMUST00000055144.7
Dph6
diphthamine biosynthesis 6
chr5_-_116591811 0.057 ENSMUST00000076124.5
Srrm4
serine/arginine repetitive matrix 4
chr14_-_12823031 0.047 ENSMUST00000067491.6
ENSMUST00000177814.1
ENSMUST00000112658.1
ENSMUST00000112657.2
Cadps



Ca2+-dependent secretion activator



chr4_+_156235999 0.042 ENSMUST00000179543.1
ENSMUST00000179886.1
Noc2l

nucleolar complex associated 2 homolog (S. cerevisiae)

chr6_+_47877204 0.024 ENSMUST00000061890.7
Zfp282
zinc finger protein 282
chr14_-_59395381 0.024 ENSMUST00000166912.2
Phf11c
PHD finger protein 11C
chr2_+_22895583 0.020 ENSMUST00000152170.1
Pdss1
prenyl (solanesyl) diphosphate synthase, subunit 1
chr2_+_22895482 0.015 ENSMUST00000053729.7
Pdss1
prenyl (solanesyl) diphosphate synthase, subunit 1
chr2_+_105904629 0.010 ENSMUST00000037499.5
Immp1l
IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr2_-_114175274 0.004 ENSMUST00000102543.4
Aqr
aquarius

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996)
0.3 1.6 GO:0070460 thyroid-stimulating hormone secretion(GO:0070460)
0.2 1.1 GO:0010626 negative regulation of Schwann cell proliferation(GO:0010626)
0.2 2.3 GO:0047484 regulation of response to osmotic stress(GO:0047484) cellular response to cholesterol(GO:0071397)
0.2 0.6 GO:1904580 regulation of intracellular mRNA localization(GO:1904580)
0.2 0.5 GO:1903011 negative regulation of bone development(GO:1903011)
0.2 0.8 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.1 0.6 GO:1903587 negative regulation of peptidyl-serine dephosphorylation(GO:1902309) regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587)
0.1 0.5 GO:0015705 iodide transport(GO:0015705)
0.1 0.8 GO:0010459 negative regulation of heart rate(GO:0010459)
0.1 1.2 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.1 1.0 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1 0.6 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 0.2 GO:0007525 somatic muscle development(GO:0007525)
0.0 0.5 GO:0097421 liver regeneration(GO:0097421)
0.0 0.3 GO:0098707 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.0 0.2 GO:0002326 B cell lineage commitment(GO:0002326) ectopic germ cell programmed cell death(GO:0035234)
0.0 0.4 GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844)
0.0 0.2 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.3 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.0 0.5 GO:0016486 peptide hormone processing(GO:0016486)
0.0 0.1 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.0 0.3 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.2 GO:0060019 radial glial cell differentiation(GO:0060019)
0.0 0.6 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.0 0.3 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.0 1.5 GO:0051028 mRNA transport(GO:0051028)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.1 2.6 GO:0000800 lateral element(GO:0000800)
0.1 0.5 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 0.3 GO:0097433 dense body(GO:0097433)
0.0 0.5 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.4 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.2 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.0 0.8 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 3.0 GO:0055037 recycling endosome(GO:0055037)
0.0 1.0 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.2 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.0 GO:0030690 Noc1p-Noc2p complex(GO:0030690)
0.0 0.5 GO:0034707 chloride channel complex(GO:0034707)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.1 0.5 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
0.1 0.2 GO:0036132 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
0.1 0.2 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.1 0.6 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.2 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.3 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.0 0.6 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 1.8 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 1.1 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.5 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 2.3 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.4 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 1.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.4 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.3 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.3 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.8 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.8 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 0.6 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 0.5 REACTOME_PEPTIDE_HORMONE_BIOSYNTHESIS Genes involved in Peptide hormone biosynthesis
0.1 0.8 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.6 REACTOME_DESTABILIZATION_OF_MRNA_BY_BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0 1.0 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions