Motif ID: Mecom

Z-value: 0.576


Transcription factors associated with Mecom:

Gene SymbolEntrez IDGene Name
Mecom ENSMUSG00000027684.10 Mecom



Activity profile for motif Mecom.

activity profile for motif Mecom


Sorted Z-values histogram for motif Mecom

Sorted Z-values for motif Mecom



Network of associatons between targets according to the STRING database.



First level regulatory network of Mecom

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrY_+_897782 12.036 ENSMUST00000055032.7
Kdm5d
lysine (K)-specific demethylase 5D
chr7_-_103853199 1.940 ENSMUST00000033229.3
Hbb-y
hemoglobin Y, beta-like embryonic chain
chr4_+_133039482 1.068 ENSMUST00000105914.1
Ahdc1
AT hook, DNA binding motif, containing 1
chr1_+_45311538 1.051 ENSMUST00000087883.6
Col3a1
collagen, type III, alpha 1
chr5_+_66259890 0.859 ENSMUST00000065530.6
Nsun7
NOL1/NOP2/Sun domain family, member 7
chr2_+_103970221 0.823 ENSMUST00000111140.2
ENSMUST00000111139.2
Lmo2

LIM domain only 2

chr10_-_6980376 0.765 ENSMUST00000105617.1
Ipcef1
interaction protein for cytohesin exchange factors 1
chr1_+_152399824 0.723 ENSMUST00000044311.8
Colgalt2
collagen beta(1-O)galactosyltransferase 2
chr1_+_120006980 0.706 ENSMUST00000072886.4
Sctr
secretin receptor
chrX_+_112604274 0.674 ENSMUST00000071814.6
Zfp711
zinc finger protein 711
chr2_+_103970115 0.644 ENSMUST00000111143.1
ENSMUST00000138815.1
Lmo2

LIM domain only 2

chr13_+_109260481 0.576 ENSMUST00000153234.1
Pde4d
phosphodiesterase 4D, cAMP specific
chrX_-_37110257 0.569 ENSMUST00000076265.6
Upf3b
UPF3 regulator of nonsense transcripts homolog B (yeast)
chrX_+_159627265 0.550 ENSMUST00000112456.2
Sh3kbp1
SH3-domain kinase binding protein 1
chr15_-_48791933 0.545 ENSMUST00000160658.1
ENSMUST00000100670.3
ENSMUST00000162830.1
Csmd3


CUB and Sushi multiple domains 3


chr2_+_103969528 0.543 ENSMUST00000123437.1
ENSMUST00000163256.1
Lmo2

LIM domain only 2

chrX_+_159627534 0.485 ENSMUST00000073094.3
Sh3kbp1
SH3-domain kinase binding protein 1
chr11_-_115367667 0.478 ENSMUST00000123428.1
ENSMUST00000044152.6
ENSMUST00000106542.2
Hid1


HID1 domain containing


chr11_-_81968415 0.463 ENSMUST00000066197.6
Asic2
acid-sensing (proton-gated) ion channel 2
chr14_+_34375504 0.439 ENSMUST00000111908.1
Mmrn2
multimerin 2
chr9_-_13245741 0.402 ENSMUST00000110582.2
Jrkl
jerky homolog-like (mouse)
chr18_-_43438280 0.398 ENSMUST00000121805.1
Dpysl3
dihydropyrimidinase-like 3
chr7_+_82337218 0.396 ENSMUST00000173828.1
Adamtsl3
ADAMTS-like 3
chr10_-_27616895 0.392 ENSMUST00000092639.5
Lama2
laminin, alpha 2
chrX_-_88760312 0.374 ENSMUST00000182943.1
Gm27000
predicted gene, 27000
chr1_+_185454803 0.298 ENSMUST00000061093.6
Slc30a10
solute carrier family 30, member 10
chr5_+_34525797 0.293 ENSMUST00000125817.1
ENSMUST00000067638.7
Sh3bp2

SH3-domain binding protein 2

chr6_+_113392417 0.278 ENSMUST00000032414.4
ENSMUST00000038889.5
Ttll3

tubulin tyrosine ligase-like family, member 3

chr19_-_37176055 0.264 ENSMUST00000142973.1
ENSMUST00000154376.1
Cpeb3

cytoplasmic polyadenylation element binding protein 3

chr9_+_64235201 0.256 ENSMUST00000039011.3
Uchl4
ubiquitin carboxyl-terminal esterase L4
chr14_+_115042752 0.249 ENSMUST00000134140.2
Mir17hg
Mir17 host gene 1 (non-protein coding)
chr10_+_5593718 0.246 ENSMUST00000051809.8
Myct1
myc target 1
chr6_+_96113146 0.245 ENSMUST00000122120.1
Fam19a1
family with sequence similarity 19, member A1
chr14_+_87416610 0.234 ENSMUST00000168275.1
ENSMUST00000169504.1
ENSMUST00000170865.1
Tdrd3


tudor domain containing 3


chr2_+_97467657 0.228 ENSMUST00000059049.7
Lrrc4c
leucine rich repeat containing 4C
chr14_-_124677089 0.214 ENSMUST00000095529.3
Fgf14
fibroblast growth factor 14
chr2_-_149798701 0.202 ENSMUST00000148202.1
ENSMUST00000139471.1
Gm14133

predicted gene 14133

chr18_+_37504264 0.193 ENSMUST00000052179.6
Pcdhb20
protocadherin beta 20
chr11_-_60046477 0.184 ENSMUST00000000310.7
ENSMUST00000102693.2
ENSMUST00000148512.1
Pemt


phosphatidylethanolamine N-methyltransferase


chr18_-_43477764 0.184 ENSMUST00000057110.9
Eif3j2
eukaryotic translation initiation factor 3, subunit J2
chr3_+_41742615 0.173 ENSMUST00000146165.1
ENSMUST00000119572.1
ENSMUST00000108065.2
ENSMUST00000120167.1
ENSMUST00000026867.7
ENSMUST00000026868.7
D3Ertd751e





DNA segment, Chr 3, ERATO Doi 751, expressed





chr9_+_44398176 0.161 ENSMUST00000165839.1
Slc37a4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr4_-_110292719 0.159 ENSMUST00000106601.1
Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr16_+_94425083 0.156 ENSMUST00000141176.1
Ttc3
tetratricopeptide repeat domain 3
chr2_-_45110336 0.147 ENSMUST00000028229.6
ENSMUST00000152232.1
Zeb2

zinc finger E-box binding homeobox 2

chr4_+_128846163 0.142 ENSMUST00000138291.1
Gm12968
predicted gene 12968
chrX_+_169879596 0.141 ENSMUST00000112105.1
ENSMUST00000078947.5
Mid1

midline 1

chr13_+_89540636 0.126 ENSMUST00000022108.7
Hapln1
hyaluronan and proteoglycan link protein 1
chr9_+_59589288 0.123 ENSMUST00000121266.1
ENSMUST00000118164.1
Celf6

CUGBP, Elav-like family member 6

chr13_-_103764502 0.118 ENSMUST00000074616.5
Srek1
splicing regulatory glutamine/lysine-rich protein 1
chr1_+_107511416 0.117 ENSMUST00000009356.4
Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr19_-_11336107 0.112 ENSMUST00000056035.2
ENSMUST00000067532.4
Ms4a7

membrane-spanning 4-domains, subfamily A, member 7

chr1_+_107511489 0.112 ENSMUST00000064916.2
Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chrX_-_113185485 0.111 ENSMUST00000026607.8
ENSMUST00000113388.2
Chm

choroidermia

chr6_-_34910869 0.093 ENSMUST00000081214.5
Wdr91
WD repeat domain 91
chr1_-_189343342 0.092 ENSMUST00000079451.6
Kcnk2
potassium channel, subfamily K, member 2
chr2_-_152830266 0.090 ENSMUST00000140436.1
Bcl2l1
BCL2-like 1
chr2_+_18672384 0.078 ENSMUST00000171845.1
ENSMUST00000061158.4
Commd3

COMM domain containing 3

chr18_+_80206887 0.062 ENSMUST00000127234.1
Gm16286
predicted gene 16286
chr11_-_116027961 0.055 ENSMUST00000106454.1
H3f3b
H3 histone, family 3B
chr5_-_136198908 0.025 ENSMUST00000149151.1
ENSMUST00000151786.1
Prkrip1

Prkr interacting protein 1 (IL11 inducible)

chr18_+_80206775 0.013 ENSMUST00000125127.1
ENSMUST00000025463.7
ENSMUST00000145963.1
ENSMUST00000025464.7
Gm16286

Txnl4a

predicted gene 16286

thioredoxin-like 4A

chr3_+_36552600 0.007 ENSMUST00000029269.5
ENSMUST00000136890.1
Exosc9

exosome component 9

chr2_-_45110241 0.003 ENSMUST00000177302.1
Zeb2
zinc finger E-box binding homeobox 2
chr9_+_72806874 0.001 ENSMUST00000055535.8
Prtg
protogenin homolog (Gallus gallus)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 12.0 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.4 1.9 GO:0015671 oxygen transport(GO:0015671)
0.2 1.1 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.2 2.0 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.2 0.5 GO:0050915 sensory perception of sour taste(GO:0050915)
0.1 0.9 GO:0030382 sperm mitochondrion organization(GO:0030382)
0.1 0.3 GO:0071579 regulation of zinc ion transport(GO:0071579)
0.1 0.3 GO:0018094 protein polyglycylation(GO:0018094)
0.1 0.3 GO:0002182 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.1 0.4 GO:0032224 positive regulation of synaptic transmission, cholinergic(GO:0032224)
0.1 0.2 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.6 GO:1901898 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.2 GO:1901843 positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.0 0.4 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.0 0.2 GO:0050747 positive regulation of lipoprotein metabolic process(GO:0050747)
0.0 0.1 GO:1900039 positive regulation of cellular response to hypoxia(GO:1900039)
0.0 0.1 GO:1903056 melanocyte migration(GO:0097324) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.0 0.1 GO:0046898 response to cycloheximide(GO:0046898)
0.0 0.4 GO:0051764 actin crosslink formation(GO:0051764)
0.0 0.1 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.1 GO:0018002 N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
0.0 0.1 GO:0018344 protein geranylgeranylation(GO:0018344)
0.0 0.1 GO:1902340 telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340)
0.0 0.6 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 0.7 GO:0030819 positive regulation of cAMP biosynthetic process(GO:0030819)
0.0 0.5 GO:0046677 response to antibiotic(GO:0046677)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.9 GO:0005833 hemoglobin complex(GO:0005833)
0.1 0.5 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)
0.1 1.1 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.8 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.1 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.4 GO:0005605 basal lamina(GO:0005605)
0.0 0.1 GO:0044305 calyx of Held(GO:0044305)
0.0 0.6 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.8 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.3 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.2 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.2 GO:0042788 polysomal ribosome(GO:0042788)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 12.0 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.5 1.9 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.1 0.3 GO:0070736 protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736)
0.1 1.1 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.4 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.0 2.0 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 0.7 GO:0035250 UDP-galactosyltransferase activity(GO:0035250)
0.0 0.2 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 0.3 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.5 GO:0005248 voltage-gated sodium channel activity(GO:0005248)
0.0 0.6 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.2 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
0.0 0.1 GO:1990190 peptide-glutamate-N-acetyltransferase activity(GO:1990190)
0.0 0.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.8 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.4 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 1.0 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.4 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 1.1 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.7 REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 0.6 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 0.1 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.6 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing