Motif ID: Sox21

Z-value: 0.548


Transcription factors associated with Sox21:

Gene SymbolEntrez IDGene Name
Sox21 ENSMUSG00000061517.7 Sox21

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox21mm10_v2_chr14_-_118237016_118237035-0.409.0e-03Click!


Activity profile for motif Sox21.

activity profile for motif Sox21


Sorted Z-values histogram for motif Sox21

Sorted Z-values for motif Sox21



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox21

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_109993982 2.354 ENSMUST00000027542.6
Cdh7
cadherin 7, type 2
chr1_+_107511416 2.006 ENSMUST00000009356.4
Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr7_+_51621830 1.748 ENSMUST00000032710.5
Slc17a6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chrM_+_14138 1.666 ENSMUST00000082421.1
mt-Cytb
mitochondrially encoded cytochrome b
chr9_-_73968901 1.524 ENSMUST00000184666.1
Unc13c
unc-13 homolog C (C. elegans)
chr18_-_34007206 1.486 ENSMUST00000025234.5
Epb4.1l4a
erythrocyte protein band 4.1-like 4a
chr12_+_38783503 1.364 ENSMUST00000159334.1
Etv1
ets variant gene 1
chr2_-_72986716 1.297 ENSMUST00000112062.1
Gm11084
predicted gene 11084
chrM_-_14060 1.265 ENSMUST00000082419.1
mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr10_-_116972609 1.167 ENSMUST00000092165.4
Gm10271
predicted gene 10271
chr6_+_120666388 1.075 ENSMUST00000112686.1
Cecr2
cat eye syndrome chromosome region, candidate 2
chr4_+_139923349 0.985 ENSMUST00000128563.1
Gm13028
predicted gene 13028
chr3_-_33082004 0.957 ENSMUST00000108225.3
Pex5l
peroxisomal biogenesis factor 5-like
chr1_+_62703667 0.906 ENSMUST00000114155.1
ENSMUST00000027112.6
ENSMUST00000063594.6
ENSMUST00000114157.2
Nrp2



neuropilin 2



chr4_-_98383232 0.860 ENSMUST00000143116.1
ENSMUST00000030292.5
ENSMUST00000102793.4
Tm2d1


TM2 domain containing 1


chr8_-_57652993 0.775 ENSMUST00000110316.2
Galnt7
UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7
chr17_-_90088343 0.705 ENSMUST00000173917.1
Nrxn1
neurexin I
chr1_-_150465563 0.700 ENSMUST00000164600.1
ENSMUST00000111902.2
ENSMUST00000111901.2
ENSMUST00000006171.9
Prg4



proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)



chr14_+_64588112 0.642 ENSMUST00000181808.1
A930011O12Rik
RIKEN cDNA A930011O12 gene
chr2_-_79908428 0.635 ENSMUST00000102652.3
ENSMUST00000102651.3
Pde1a

phosphodiesterase 1A, calmodulin-dependent

chr19_+_44493472 0.617 ENSMUST00000041163.4
Wnt8b
wingless related MMTV integration site 8b
chr7_-_25675047 0.592 ENSMUST00000108404.1
ENSMUST00000108405.1
ENSMUST00000079439.3
Tmem91


transmembrane protein 91


chrX_-_75578188 0.586 ENSMUST00000033545.5
Rab39b
RAB39B, member RAS oncogene family
chr2_+_136713444 0.571 ENSMUST00000028727.4
ENSMUST00000110098.3
Snap25

synaptosomal-associated protein 25

chr9_-_79793378 0.521 ENSMUST00000034878.5
Tmem30a
transmembrane protein 30A
chrM_+_10167 0.520 ENSMUST00000082414.1
mt-Nd4
mitochondrially encoded NADH dehydrogenase 4
chr5_+_144255223 0.513 ENSMUST00000056578.6
Bri3
brain protein I3
chr9_-_79793507 0.512 ENSMUST00000120690.1
Tmem30a
transmembrane protein 30A
chr8_-_111393810 0.493 ENSMUST00000038475.8
Fa2h
fatty acid 2-hydroxylase
chr2_-_79908389 0.463 ENSMUST00000090756.4
Pde1a
phosphodiesterase 1A, calmodulin-dependent
chr3_+_16183177 0.452 ENSMUST00000108345.2
ENSMUST00000108346.2
Ythdf3

YTH domain family 3

chr16_-_59632520 0.445 ENSMUST00000118438.1
Arl6
ADP-ribosylation factor-like 6
chr1_-_24612700 0.411 ENSMUST00000088336.1
Gm10222
predicted gene 10222
chr11_+_69964758 0.400 ENSMUST00000108597.1
ENSMUST00000060651.5
ENSMUST00000108596.1
Cldn7


claudin 7


chr1_+_171113918 0.396 ENSMUST00000129651.1
ENSMUST00000151340.1
1700009P17Rik

RIKEN cDNA 1700009P17 gene

chr2_+_173737492 0.392 ENSMUST00000067530.4
Vapb
vesicle-associated membrane protein, associated protein B and C
chr4_+_116708467 0.389 ENSMUST00000030452.6
Ccdc163
coiled-coil domain containing 163
chr6_-_86733268 0.381 ENSMUST00000001185.7
Gmcl1
germ cell-less homolog 1 (Drosophila)
chr1_+_74362108 0.374 ENSMUST00000097697.1
Gm216
predicted gene 216
chr17_-_6655939 0.371 ENSMUST00000179554.1
Dynlt1f
dynein light chain Tctex-type 1F
chr1_-_135585314 0.360 ENSMUST00000040599.8
ENSMUST00000067414.6
Nav1

neuron navigator 1

chr17_-_6317474 0.353 ENSMUST00000169415.1
Dynlt1a
dynein light chain Tctex-type 1A
chr9_-_104063049 0.329 ENSMUST00000035166.5
Uba5
ubiquitin-like modifier activating enzyme 5
chr18_-_67549173 0.329 ENSMUST00000115050.1
Spire1
spire homolog 1 (Drosophila)
chr4_-_131967824 0.329 ENSMUST00000146443.1
ENSMUST00000135579.1
Epb4.1

erythrocyte protein band 4.1

chr11_+_88047302 0.328 ENSMUST00000139129.2
Srsf1
serine/arginine-rich splicing factor 1
chr10_-_62507737 0.319 ENSMUST00000020271.6
Srgn
serglycin
chr5_+_66676098 0.295 ENSMUST00000031131.9
Uchl1
ubiquitin carboxy-terminal hydrolase L1
chr17_-_70998010 0.277 ENSMUST00000024846.6
Myl12a
myosin, light chain 12A, regulatory, non-sarcomeric
chr17_+_6430112 0.274 ENSMUST00000179569.1
Dynlt1b
dynein light chain Tctex-type 1B
chr3_-_59220150 0.268 ENSMUST00000170388.1
P2ry12
purinergic receptor P2Y, G-protein coupled 12
chr19_-_24961545 0.268 ENSMUST00000025815.8
Cbwd1
COBW domain containing 1
chr2_+_132686931 0.247 ENSMUST00000061891.4
1110034G24Rik
RIKEN cDNA 1110034G24 gene
chr17_+_6601671 0.241 ENSMUST00000092966.4
Dynlt1c
dynein light chain Tctex-type 1C
chr2_+_29802626 0.237 ENSMUST00000080065.2
Slc27a4
solute carrier family 27 (fatty acid transporter), member 4
chr5_+_23787691 0.231 ENSMUST00000030852.6
ENSMUST00000120869.1
ENSMUST00000117783.1
ENSMUST00000115113.2
Rint1



RAD50 interactor 1



chr1_-_125913101 0.231 ENSMUST00000161361.1
Lypd1
Ly6/Plaur domain containing 1
chr3_+_32436376 0.228 ENSMUST00000108242.1
Pik3ca
phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
chr10_-_39122277 0.223 ENSMUST00000136546.1
Fam229b
family with sequence similarity 229, member B
chrM_+_11734 0.219 ENSMUST00000082418.1
mt-Nd5
mitochondrially encoded NADH dehydrogenase 5
chr13_-_85127514 0.212 ENSMUST00000179230.1
Gm4076
predicted gene 4076
chr12_+_100110148 0.210 ENSMUST00000021595.8
Psmc1
protease (prosome, macropain) 26S subunit, ATPase 1
chr19_-_8798495 0.205 ENSMUST00000096261.3
Polr2g
polymerase (RNA) II (DNA directed) polypeptide G
chr13_-_99344652 0.202 ENSMUST00000022153.6
Ptcd2
pentatricopeptide repeat domain 2
chr2_+_174450678 0.201 ENSMUST00000016399.5
Tubb1
tubulin, beta 1 class VI
chr2_+_73312601 0.198 ENSMUST00000090811.4
ENSMUST00000112050.1
Scrn3

secernin 3

chr19_+_11518493 0.197 ENSMUST00000025580.3
Ms4a6b
membrane-spanning 4-domains, subfamily A, member 6B
chr8_-_41054771 0.195 ENSMUST00000093534.4
Mtus1
mitochondrial tumor suppressor 1
chr4_+_146654927 0.193 ENSMUST00000070932.3
Gm13248
predicted gene 13248
chr5_-_87490869 0.188 ENSMUST00000147854.1
Ugt2a1
UDP glucuronosyltransferase 2 family, polypeptide A1
chr10_-_18023229 0.188 ENSMUST00000020002.7
Abracl
ABRA C-terminal like
chr2_-_140671462 0.185 ENSMUST00000110057.2
Flrt3
fibronectin leucine rich transmembrane protein 3
chr8_+_85432686 0.182 ENSMUST00000180883.1
1700051O22Rik
RIKEN cDNA 1700051O22 Gene
chr4_-_25281752 0.176 ENSMUST00000038705.7
Ufl1
UFM1 specific ligase 1
chr2_+_70508813 0.171 ENSMUST00000100041.2
Erich2
glutamate rich 2
chr13_+_97137937 0.170 ENSMUST00000042084.6
ENSMUST00000160139.1
ENSMUST00000161639.1
ENSMUST00000161913.1
ENSMUST00000161825.1
ENSMUST00000161929.1
ENSMUST00000022170.7
Gfm2






G elongation factor, mitochondrial 2






chr7_+_141195047 0.169 ENSMUST00000047093.4
Lrrc56
leucine rich repeat containing 56
chr4_-_25281801 0.165 ENSMUST00000102994.3
Ufl1
UFM1 specific ligase 1
chr2_-_155582656 0.163 ENSMUST00000126322.1
Gss
glutathione synthetase
chr3_-_130709419 0.157 ENSMUST00000043937.7
Ostc
oligosaccharyltransferase complex subunit
chr17_+_35342242 0.155 ENSMUST00000074806.5
H2-Q2
histocompatibility 2, Q region locus 2
chr3_-_100685431 0.145 ENSMUST00000008907.7
Man1a2
mannosidase, alpha, class 1A, member 2
chr8_-_18741542 0.144 ENSMUST00000033846.6
Angpt2
angiopoietin 2
chr8_+_33517306 0.143 ENSMUST00000124496.1
Tex15
testis expressed gene 15
chr15_+_6708372 0.143 ENSMUST00000061656.6
Rictor
RPTOR independent companion of MTOR, complex 2
chr10_-_115362191 0.137 ENSMUST00000092170.5
Tmem19
transmembrane protein 19
chr18_+_4993795 0.134 ENSMUST00000153016.1
Svil
supervillin
chr16_+_32247221 0.132 ENSMUST00000178573.1
ENSMUST00000023474.3
Wdr53

WD repeat domain 53

chr17_-_26099257 0.130 ENSMUST00000053575.3
Gm8186
predicted gene 8186
chr2_-_35979624 0.130 ENSMUST00000028248.4
ENSMUST00000112976.2
Ttll11

tubulin tyrosine ligase-like family, member 11

chr9_-_64341288 0.128 ENSMUST00000068367.7
Dis3l
DIS3 mitotic control homolog (S. cerevisiae)-like
chr7_+_123123870 0.128 ENSMUST00000094053.5
Tnrc6a
trinucleotide repeat containing 6a
chr13_-_32851176 0.127 ENSMUST00000091668.5
ENSMUST00000076352.6
Serpinb1a

serine (or cysteine) peptidase inhibitor, clade B, member 1a

chr8_-_54724474 0.126 ENSMUST00000175915.1
Wdr17
WD repeat domain 17
chr2_-_73312701 0.125 ENSMUST00000058615.9
Cir1
corepressor interacting with RBPJ, 1
chr8_+_104961713 0.124 ENSMUST00000043183.7
Ces2g
carboxylesterase 2G
chr4_+_116557658 0.118 ENSMUST00000030460.8
Gpbp1l1
GC-rich promoter binding protein 1-like 1
chr1_-_97661950 0.117 ENSMUST00000053033.7
ENSMUST00000149927.1
D1Ertd622e

DNA segment, Chr 1, ERATO Doi 622, expressed

chr17_+_29268788 0.111 ENSMUST00000064709.5
ENSMUST00000120346.1
BC004004

cDNA sequence BC004004

chr9_+_75051977 0.107 ENSMUST00000170310.1
ENSMUST00000166549.1
Arpp19

cAMP-regulated phosphoprotein 19

chr9_-_69451035 0.105 ENSMUST00000071565.5
Gm4978
predicted gene 4978
chrX_+_166170449 0.097 ENSMUST00000130880.2
ENSMUST00000056410.4
ENSMUST00000096252.3
ENSMUST00000087169.4
Gemin8



gem (nuclear organelle) associated protein 8



chr11_+_87699897 0.089 ENSMUST00000040089.4
Rnf43
ring finger protein 43
chr15_+_31602106 0.088 ENSMUST00000042702.6
Fam173b
family with sequence similarity 173, member B
chr7_+_6961160 0.087 ENSMUST00000054055.6
Usp29
ubiquitin specific peptidase 29
chr1_-_172027269 0.078 ENSMUST00000027837.6
ENSMUST00000111264.1
Vangl2

vang-like 2 (van gogh, Drosophila)

chr2_-_170194033 0.071 ENSMUST00000180625.1
Gm17619
predicted gene, 17619
chr3_-_19264959 0.069 ENSMUST00000121951.1
Pde7a
phosphodiesterase 7A
chr9_+_109051090 0.061 ENSMUST00000059097.8
Shisa5
shisa homolog 5 (Xenopus laevis)
chr6_-_35539765 0.055 ENSMUST00000031866.5
Mtpn
myotrophin
chr19_-_37176055 0.054 ENSMUST00000142973.1
ENSMUST00000154376.1
Cpeb3

cytoplasmic polyadenylation element binding protein 3

chr1_+_72284367 0.053 ENSMUST00000027380.5
ENSMUST00000141783.1
Tmem169

transmembrane protein 169

chr7_+_80862108 0.052 ENSMUST00000044115.7
Zscan2
zinc finger and SCAN domain containing 2
chr5_+_143403819 0.051 ENSMUST00000110731.2
Kdelr2
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
chr8_-_107439585 0.050 ENSMUST00000077208.4
Rps26-ps1
ribosomal protein S26, pseudogene 1
chr3_+_94443315 0.049 ENSMUST00000029786.7
ENSMUST00000098876.3
Mrpl9

mitochondrial ribosomal protein L9

chr4_-_49593875 0.040 ENSMUST00000151542.1
Tmem246
transmembrane protein 246
chr6_-_56797637 0.039 ENSMUST00000114323.1
Kbtbd2
kelch repeat and BTB (POZ) domain containing 2
chr17_-_35916323 0.036 ENSMUST00000172642.1
ENSMUST00000174807.1
ENSMUST00000174349.1
ENSMUST00000025305.9
ENSMUST00000113782.3
Mrps18b




mitochondrial ribosomal protein S18B




chr3_-_10208569 0.033 ENSMUST00000029041.4
Fabp4
fatty acid binding protein 4, adipocyte
chr11_+_35769462 0.024 ENSMUST00000018990.7
Pank3
pantothenate kinase 3
chr12_-_40134175 0.013 ENSMUST00000078481.7
ENSMUST00000002640.5
Scin

scinderin


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.7 GO:0033762 response to glucagon(GO:0033762)
0.3 0.9 GO:0021649 vestibulocochlear nerve structural organization(GO:0021649) ganglion morphogenesis(GO:0061552) dorsal root ganglion morphogenesis(GO:1904835)
0.2 1.7 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.2 0.7 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.2 0.7 GO:0045409 negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.2 1.5 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.2 1.0 GO:0051461 regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.1 1.0 GO:0070863 positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.1 1.4 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 1.1 GO:0001842 neural fold formation(GO:0001842)
0.1 0.7 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.1 0.4 GO:0046909 intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445)
0.1 0.3 GO:0070649 formin-nucleated actin cable assembly(GO:0070649)
0.1 0.3 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.1 0.4 GO:0044830 modulation by host of viral RNA genome replication(GO:0044830)
0.1 0.3 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.1 0.2 GO:0072425 signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434)
0.1 0.2 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.1 0.3 GO:0007412 axon target recognition(GO:0007412)
0.1 0.6 GO:0098967 exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967)
0.1 0.2 GO:0003345 proepicardium cell migration involved in pericardium morphogenesis(GO:0003345)
0.1 1.1 GO:0046069 cGMP catabolic process(GO:0046069)
0.1 0.5 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.0 0.1 GO:0048014 Tie signaling pathway(GO:0048014)
0.0 0.3 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.2 GO:0052695 cellular glucuronidation(GO:0052695)
0.0 0.4 GO:0032460 negative regulation of protein oligomerization(GO:0032460) negative regulation of protein homooligomerization(GO:0032463)
0.0 0.5 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.7 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.0 0.1 GO:2000812 regulation of barbed-end actin filament capping(GO:2000812)
0.0 2.4 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.2 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.0 0.2 GO:0032790 ribosome disassembly(GO:0032790)
0.0 0.1 GO:0051013 microtubule severing(GO:0051013)
0.0 0.1 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0 0.1 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.0 0.1 GO:0002182 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.0 0.2 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.0 0.1 GO:1901727 positive regulation of histone deacetylase activity(GO:1901727)
0.0 0.8 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.0 0.1 GO:0010764 negative regulation of fibroblast migration(GO:0010764) negative regulation of cytokine production involved in inflammatory response(GO:1900016)
0.0 2.1 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.0 0.1 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
0.0 0.2 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.0 0.1 GO:0030539 male genitalia development(GO:0030539)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:0090537 CERF complex(GO:0090537)
0.3 1.5 GO:0044305 calyx of Held(GO:0044305)
0.2 1.0 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.2 1.7 GO:0045275 respiratory chain complex III(GO:0045275)
0.1 0.6 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.1 0.2 GO:0070939 Dsl1p complex(GO:0070939)
0.1 1.7 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 0.2 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.3 GO:0042629 mast cell granule(GO:0042629)
0.0 1.2 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 2.0 GO:0070469 respiratory chain(GO:0070469)
0.0 0.2 GO:0031595 nuclear proteasome complex(GO:0031595)
0.0 0.7 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.4 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.3 GO:0016460 myosin II complex(GO:0016460)
0.0 0.2 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.1 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 0.4 GO:0043194 axon initial segment(GO:0043194)
0.0 0.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.2 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0001565 phorbol ester receptor activity(GO:0001565) non-kinase phorbol ester receptor activity(GO:0001566)
0.2 1.7 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.2 1.0 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.2 1.1 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 0.9 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.1 0.3 GO:0071568 UFM1 transferase activity(GO:0071568)
0.1 1.7 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.1 0.3 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.1 2.0 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.7 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 0.3 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.0 2.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.5 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.8 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.7 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.3 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.2 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.0 0.2 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0 0.2 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.0 0.6 GO:0031489 myosin V binding(GO:0031489)
0.0 0.3 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.0 0.6 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.2 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.7 GO:0005109 frizzled binding(GO:0005109)
0.0 0.3 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.1 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.9 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.2 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.1 GO:0046923 ER retention sequence binding(GO:0046923)
0.0 0.2 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.0 0.2 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.2 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.2 GO:0016594 glycine binding(GO:0016594)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 1.4 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.0 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 2.0 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.2 PID_IL5_PATHWAY IL5-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 2.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 0.6 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 1.1 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 1.7 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 0.3 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.2 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.8 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.4 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.1 REACTOME_CD28_DEPENDENT_PI3K_AKT_SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.0 0.1 REACTOME_MEIOSIS Genes involved in Meiosis
0.0 0.2 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.4 REACTOME_CELL_CELL_JUNCTION_ORGANIZATION Genes involved in Cell-cell junction organization
0.0 0.3 REACTOME_REGULATORY_RNA_PATHWAYS Genes involved in Regulatory RNA pathways