Motif ID: Evx2

Z-value: 0.524


Transcription factors associated with Evx2:

Gene SymbolEntrez IDGene Name
Evx2 ENSMUSG00000001815.9 Evx2



Activity profile for motif Evx2.

activity profile for motif Evx2


Sorted Z-values histogram for motif Evx2

Sorted Z-values for motif Evx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Evx2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_60893430 6.502 ENSMUST00000135107.2
Sox3
SRY-box containing gene 3
chr2_-_168767136 4.233 ENSMUST00000029061.5
ENSMUST00000103074.1
Sall4

sal-like 4 (Drosophila)

chr2_-_168767029 3.162 ENSMUST00000075044.3
Sall4
sal-like 4 (Drosophila)
chr17_+_17402672 2.139 ENSMUST00000115576.2
Lix1
limb expression 1 homolog (chicken)
chr4_+_109978004 2.123 ENSMUST00000061187.3
Dmrta2
doublesex and mab-3 related transcription factor like family A2
chr13_+_51645232 2.024 ENSMUST00000075853.5
Cks2
CDC28 protein kinase regulatory subunit 2
chr6_-_124779686 1.840 ENSMUST00000147669.1
ENSMUST00000128697.1
ENSMUST00000032218.3
ENSMUST00000112475.2
Lrrc23



leucine rich repeat containing 23



chr7_-_143460989 1.806 ENSMUST00000167912.1
ENSMUST00000037287.6
Cdkn1c

cyclin-dependent kinase inhibitor 1C (P57)

chr4_-_132345686 1.757 ENSMUST00000030726.6
Rcc1
regulator of chromosome condensation 1
chr4_-_132345715 1.704 ENSMUST00000084250.4
Rcc1
regulator of chromosome condensation 1
chr2_-_155074447 1.511 ENSMUST00000137242.1
ENSMUST00000054607.9
Ahcy

S-adenosylhomocysteine hydrolase

chr9_+_47530173 1.502 ENSMUST00000114548.1
ENSMUST00000152459.1
ENSMUST00000143026.1
ENSMUST00000085909.2
ENSMUST00000114547.1
ENSMUST00000034581.3
Cadm1





cell adhesion molecule 1





chr2_+_91257323 1.338 ENSMUST00000111349.2
ENSMUST00000131711.1
Pacsin3

protein kinase C and casein kinase substrate in neurons 3

chr18_-_88927447 1.187 ENSMUST00000147313.1
Socs6
suppressor of cytokine signaling 6
chr2_+_91256813 1.182 ENSMUST00000144394.1
ENSMUST00000028694.5
ENSMUST00000168916.1
ENSMUST00000156919.1
Pacsin3



protein kinase C and casein kinase substrate in neurons 3



chr10_-_8886033 1.142 ENSMUST00000015449.5
Sash1
SAM and SH3 domain containing 1
chr7_-_126800354 1.091 ENSMUST00000106348.1
Aldoa
aldolase A, fructose-bisphosphate
chr14_+_62292475 1.032 ENSMUST00000166879.1
Rnaseh2b
ribonuclease H2, subunit B
chr9_-_66514567 1.029 ENSMUST00000056890.8
Fbxl22
F-box and leucine-rich repeat protein 22
chr19_+_47067721 0.911 ENSMUST00000026027.5
Taf5
TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr3_-_130709419 0.793 ENSMUST00000043937.7
Ostc
oligosaccharyltransferase complex subunit
chrX_+_58030999 0.744 ENSMUST00000088631.4
ENSMUST00000088629.3
Zic3

zinc finger protein of the cerebellum 3

chr4_+_140701466 0.724 ENSMUST00000038893.5
ENSMUST00000138808.1
Rcc2

regulator of chromosome condensation 2

chr11_+_60537978 0.719 ENSMUST00000044250.3
Alkbh5
alkB, alkylation repair homolog 5 (E. coli)
chr2_-_132247747 0.693 ENSMUST00000110163.1
ENSMUST00000180286.1
ENSMUST00000028816.2
Tmem230


transmembrane protein 230


chr3_+_121291725 0.679 ENSMUST00000039442.7
Alg14
asparagine-linked glycosylation 14
chr7_+_51879041 0.564 ENSMUST00000107591.2
Gas2
growth arrest specific 2
chr4_-_129227883 0.504 ENSMUST00000106051.1
C77080
expressed sequence C77080
chr2_-_150255591 0.462 ENSMUST00000063463.5
Gm21994
predicted gene 21994
chr16_-_42340595 0.432 ENSMUST00000102817.4
Gap43
growth associated protein 43
chrX_+_58030622 0.427 ENSMUST00000088627.4
Zic3
zinc finger protein of the cerebellum 3
chr14_+_73173825 0.418 ENSMUST00000166875.1
Rcbtb2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr4_-_132075250 0.389 ENSMUST00000105970.1
ENSMUST00000105975.1
Epb4.1

erythrocyte protein band 4.1

chr8_+_92855319 0.384 ENSMUST00000046290.1
Lpcat2
lysophosphatidylcholine acyltransferase 2
chr6_-_69284319 0.343 ENSMUST00000103349.1
Igkv4-69
immunoglobulin kappa variable 4-69
chr10_-_80701811 0.303 ENSMUST00000003438.9
Mob3a
MOB kinase activator 3A
chr14_-_59365410 0.295 ENSMUST00000161031.1
ENSMUST00000160425.1
Phf11d

PHD finger protein 11D

chr4_-_42661893 0.294 ENSMUST00000108006.3
Il11ra2
interleukin 11 receptor, alpha chain 2
chr6_-_69400097 0.283 ENSMUST00000177795.1
Igkv4-62
immunoglobulin kappa variable 4-62
chr17_-_47834682 0.277 ENSMUST00000066368.6
Mdfi
MyoD family inhibitor
chr2_+_119047116 0.181 ENSMUST00000152380.1
ENSMUST00000099542.2
Casc5

cancer susceptibility candidate 5

chrM_+_7759 0.170 ENSMUST00000082407.1
ENSMUST00000082408.1
mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr7_-_44257378 0.146 ENSMUST00000107945.1
ENSMUST00000118216.1
Acpt

acid phosphatase, testicular

chr2_+_69822370 0.144 ENSMUST00000053087.3
Klhl23
kelch-like 23
chr15_-_58034289 0.133 ENSMUST00000100655.3
9130401M01Rik
RIKEN cDNA 9130401M01 gene
chr19_-_41933276 0.127 ENSMUST00000075280.4
ENSMUST00000112123.2
Exosc1

exosome component 1

chr2_-_27475622 0.126 ENSMUST00000138693.1
ENSMUST00000113941.2
ENSMUST00000077737.6
Brd3


bromodomain containing 3


chr19_+_41933464 0.110 ENSMUST00000026154.7
Zdhhc16
zinc finger, DHHC domain containing 16
chr8_-_31168699 0.095 ENSMUST00000033983.4
Mak16
MAK16 homolog (S. cerevisiae)
chr5_-_98030727 0.089 ENSMUST00000031281.9
Antxr2
anthrax toxin receptor 2
chr17_+_36837123 0.080 ENSMUST00000179968.1
ENSMUST00000130367.1
ENSMUST00000130801.1
ENSMUST00000144182.1
ENSMUST00000123715.1
ENSMUST00000053434.8
Trim26





tripartite motif-containing 26





chrX_-_111536325 0.060 ENSMUST00000156639.1
Rps6ka6
ribosomal protein S6 kinase polypeptide 6
chr8_+_14888022 0.040 ENSMUST00000123990.1
ENSMUST00000027554.7
Cln8

ceroid-lipofuscinosis, neuronal 8

chr19_+_5088534 0.030 ENSMUST00000025811.4
Yif1a
Yip1 interacting factor homolog A (S. cerevisiae)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0009826 unidimensional cell growth(GO:0009826) susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.4 7.4 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.4 1.1 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.3 6.5 GO:0007530 sex determination(GO:0007530)
0.2 1.8 GO:1902746 regulation of lens fiber cell differentiation(GO:1902746)
0.2 1.2 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.2 1.5 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.2 0.7 GO:0035553 oxidative single-stranded RNA demethylation(GO:0035553)
0.1 2.1 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.1 0.7 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.1 1.1 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1 2.5 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 0.4 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
0.1 2.1 GO:0097352 autophagosome maturation(GO:0097352)
0.1 3.5 GO:0051290 protein heterotetramerization(GO:0051290)
0.1 0.7 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 0.4 GO:0016198 axon choice point recognition(GO:0016198)
0.0 0.9 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.0 2.0 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.0 0.3 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
0.0 1.2 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.0 GO:0021523 somatic motor neuron differentiation(GO:0021523)
0.0 0.9 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.1 1.5 GO:0070852 cell body fiber(GO:0070852)
0.1 8.0 GO:0000792 heterochromatin(GO:0000792)
0.1 0.7 GO:1990023 mitotic spindle midzone(GO:1990023)
0.1 0.8 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.9 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 3.5 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 3.1 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.2 GO:0001772 immunological synapse(GO:0001772)
0.0 0.4 GO:0031527 filopodium membrane(GO:0031527)
0.0 3.2 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.2 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.1 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.5 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.5 2.0 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.2 1.5 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.2 2.5 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.2 1.1 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.2 0.7 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.2 6.5 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 1.0 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.1 1.8 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 0.4 GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.1 0.4 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 1.1 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 0.9 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 1.5 GO:0030165 PDZ domain binding(GO:0030165)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 7.4 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 3.5 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.1 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 1.2 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 1.5 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 4.4 REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE Genes involved in Late Phase of HIV Life Cycle
0.0 1.1 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.4 REACTOME_ACYL_CHAIN_REMODELLING_OF_PC Genes involved in Acyl chain remodelling of PC
0.0 0.6 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.7 REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.1 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease