Motif ID: Ppard

Z-value: 0.474


Transcription factors associated with Ppard:

Gene SymbolEntrez IDGene Name
Ppard ENSMUSG00000002250.9 Ppard

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ppardmm10_v2_chr17_+_28232723_282327890.182.5e-01Click!


Activity profile for motif Ppard.

activity profile for motif Ppard


Sorted Z-values histogram for motif Ppard

Sorted Z-values for motif Ppard



Network of associatons between targets according to the STRING database.



First level regulatory network of Ppard

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_87948666 5.296 ENSMUST00000005019.5
Crabp2
cellular retinoic acid binding protein II
chr10_-_13324160 2.105 ENSMUST00000105545.4
Phactr2
phosphatase and actin regulator 2
chr1_-_120120138 2.044 ENSMUST00000112648.1
ENSMUST00000128408.1
Dbi

diazepam binding inhibitor

chr3_-_8923796 1.145 ENSMUST00000042148.5
Mrps28
mitochondrial ribosomal protein S28
chr11_-_4704334 1.124 ENSMUST00000058407.5
Uqcr10
ubiquinol-cytochrome c reductase, complex III subunit X
chr9_-_57262591 1.104 ENSMUST00000034846.5
1700017B05Rik
RIKEN cDNA 1700017B05 gene
chr5_-_115119277 1.078 ENSMUST00000031524.7
Acads
acyl-Coenzyme A dehydrogenase, short chain
chr4_+_98546710 1.055 ENSMUST00000102792.3
Inadl
InaD-like (Drosophila)
chr4_+_118429701 1.048 ENSMUST00000067896.3
Elovl1
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1
chr4_+_98546919 1.012 ENSMUST00000030290.7
Inadl
InaD-like (Drosophila)
chr4_+_59581563 1.012 ENSMUST00000030078.5
Hsdl2
hydroxysteroid dehydrogenase like 2
chr17_-_34028044 0.999 ENSMUST00000045467.7
ENSMUST00000114303.3
H2-Ke6

H2-K region expressed gene 6

chr10_+_93589413 0.898 ENSMUST00000181835.1
4933408J17Rik
RIKEN cDNA 4933408J17 gene
chr4_+_59581645 0.854 ENSMUST00000107528.1
Hsdl2
hydroxysteroid dehydrogenase like 2
chr5_-_31697598 0.848 ENSMUST00000031018.7
Rbks
ribokinase
chr7_+_43444104 0.839 ENSMUST00000004729.3
Etfb
electron transferring flavoprotein, beta polypeptide
chr5_+_110286306 0.820 ENSMUST00000007296.5
ENSMUST00000112482.1
Pole

polymerase (DNA directed), epsilon

chr15_+_25773985 0.794 ENSMUST00000125667.1
Myo10
myosin X
chr18_+_74779190 0.786 ENSMUST00000041053.9
Acaa2
acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)
chr3_-_138131356 0.782 ENSMUST00000029805.8
Mttp
microsomal triglyceride transfer protein
chr2_-_73911323 0.722 ENSMUST00000111996.1
ENSMUST00000018914.2
Atp5g3

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9)

chr5_+_129725063 0.717 ENSMUST00000086046.3
Gbas
glioblastoma amplified sequence
chr19_+_37207528 0.685 ENSMUST00000024078.7
ENSMUST00000112391.1
March5

membrane-associated ring finger (C3HC4) 5

chr4_-_45108038 0.685 ENSMUST00000107809.2
ENSMUST00000107808.2
ENSMUST00000107807.1
ENSMUST00000107810.2
Tomm5



translocase of outer mitochondrial membrane 5 homolog (yeast)



chr16_+_84835070 0.657 ENSMUST00000009120.7
Gabpa
GA repeat binding protein, alpha
chr11_+_70657687 0.649 ENSMUST00000134087.1
ENSMUST00000170716.1
Eno3

enolase 3, beta muscle

chr9_-_22002599 0.644 ENSMUST00000115336.2
ENSMUST00000044926.5
Ccdc151

coiled-coil domain containing 151

chr10_-_93589621 0.630 ENSMUST00000020203.6
Snrpf
small nuclear ribonucleoprotein polypeptide F
chr5_-_110286159 0.625 ENSMUST00000031472.5
Pxmp2
peroxisomal membrane protein 2
chr16_-_84835557 0.622 ENSMUST00000138279.1
ENSMUST00000023608.7
Atp5j

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F

chr4_+_118409331 0.607 ENSMUST00000084319.4
ENSMUST00000106384.3
ENSMUST00000126089.1
ENSMUST00000073881.1
ENSMUST00000019229.8
ENSMUST00000144577.1
Med8





mediator of RNA polymerase II transcription, subunit 8 homolog (yeast)





chr13_-_86046901 0.579 ENSMUST00000131011.1
Cox7c
cytochrome c oxidase subunit VIIc
chr15_-_89425856 0.577 ENSMUST00000109313.2
Cpt1b
carnitine palmitoyltransferase 1b, muscle
chr8_-_111393810 0.537 ENSMUST00000038475.8
Fa2h
fatty acid 2-hydroxylase
chr10_+_94147982 0.536 ENSMUST00000105290.2
Nr2c1
nuclear receptor subfamily 2, group C, member 1
chr1_-_55088024 0.519 ENSMUST00000027123.8
Hspd1
heat shock protein 1 (chaperonin)
chr2_+_75832168 0.469 ENSMUST00000047232.7
ENSMUST00000111952.2
Agps

alkylglycerone phosphate synthase

chr18_-_36726730 0.467 ENSMUST00000061829.6
Cd14
CD14 antigen
chr16_-_84835484 0.442 ENSMUST00000114191.1
Atp5j
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F
chr12_-_40223149 0.441 ENSMUST00000171553.1
ENSMUST00000001672.5
Ifrd1

interferon-related developmental regulator 1

chr1_+_55088132 0.426 ENSMUST00000075242.6
Hspe1
heat shock protein 1 (chaperonin 10)
chr15_-_102189032 0.424 ENSMUST00000023805.1
Csad
cysteine sulfinic acid decarboxylase
chr15_-_50890396 0.373 ENSMUST00000185183.1
Trps1
trichorhinophalangeal syndrome I (human)
chr6_+_83156401 0.326 ENSMUST00000032106.4
1700003E16Rik
RIKEN cDNA 1700003E16 gene
chr1_+_178319130 0.307 ENSMUST00000027781.6
Cox20
COX20 Cox2 chaperone
chr4_-_137048695 0.300 ENSMUST00000049583.7
Zbtb40
zinc finger and BTB domain containing 40
chr1_+_171329376 0.298 ENSMUST00000111299.1
ENSMUST00000064950.4
Dedd

death effector domain-containing

chr2_-_32704123 0.267 ENSMUST00000127812.1
Fpgs
folylpolyglutamyl synthetase
chrX_-_142306170 0.264 ENSMUST00000134825.2
Kcne1l
potassium voltage-gated channel, Isk-related family, member 1-like, pseudogene
chr3_+_90051630 0.262 ENSMUST00000159064.1
4933434E20Rik
RIKEN cDNA 4933434E20 gene
chr5_+_36464998 0.261 ENSMUST00000031099.3
Grpel1
GrpE-like 1, mitochondrial
chr11_-_70015346 0.250 ENSMUST00000018718.7
ENSMUST00000102574.3
Acadvl

acyl-Coenzyme A dehydrogenase, very long chain

chr2_-_26237368 0.225 ENSMUST00000036187.8
Qsox2
quiescin Q6 sulfhydryl oxidase 2
chr14_+_75136326 0.224 ENSMUST00000145303.1
Lcp1
lymphocyte cytosolic protein 1
chr9_-_51278540 0.186 ENSMUST00000114427.3
Gm684
predicted gene 684
chr9_-_107872687 0.134 ENSMUST00000035201.6
Rbm6
RNA binding motif protein 6
chr7_+_82648595 0.120 ENSMUST00000141726.1
ENSMUST00000179489.1
ENSMUST00000039881.3
Eftud1


elongation factor Tu GTP binding domain containing 1


chr9_-_107872821 0.117 ENSMUST00000183032.1
Rbm6
RNA binding motif protein 6
chr8_+_117095854 0.109 ENSMUST00000034308.8
ENSMUST00000167370.1
ENSMUST00000176860.1
Bcmo1


beta-carotene 15,15'-monooxygenase


chr6_+_85431970 0.098 ENSMUST00000045693.7
Smyd5
SET and MYND domain containing 5
chr11_+_98446826 0.082 ENSMUST00000019456.4
Grb7
growth factor receptor bound protein 7
chr15_-_89425795 0.077 ENSMUST00000168376.1
Cpt1b
carnitine palmitoyltransferase 1b, muscle
chr1_+_74506044 0.077 ENSMUST00000087215.5
Rqcd1
rcd1 (required for cell differentiation) homolog 1 (S. pombe)
chr16_-_3907651 0.040 ENSMUST00000177221.1
ENSMUST00000177323.1
1700037C18Rik

RIKEN cDNA 1700037C18 gene

chr4_+_131873608 0.023 ENSMUST00000053819.3
Srsf4
serine/arginine-rich splicing factor 4
chr1_-_124045247 0.023 ENSMUST00000112603.2
Dpp10
dipeptidylpeptidase 10
chr9_+_22003035 0.018 ENSMUST00000115331.2
ENSMUST00000003493.7
Prkcsh

protein kinase C substrate 80K-H

chr1_-_124045523 0.009 ENSMUST00000112606.1
Dpp10
dipeptidylpeptidase 10

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 0.5 GO:0071726 response to diacyl bacterial lipopeptide(GO:0071724) cellular response to diacyl bacterial lipopeptide(GO:0071726)
0.4 2.0 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
0.4 5.3 GO:0042573 retinoic acid metabolic process(GO:0042573)
0.3 0.8 GO:0045004 DNA replication proofreading(GO:0045004)
0.2 0.8 GO:0006014 D-ribose metabolic process(GO:0006014)
0.2 0.8 GO:1902109 negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109)
0.2 0.5 GO:0002842 positive regulation of T cell mediated immune response to tumor cell(GO:0002842) protein import into mitochondrial intermembrane space(GO:0045041)
0.2 0.8 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.1 1.0 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.1 1.1 GO:0046459 short-chain fatty acid metabolic process(GO:0046459)
0.1 1.1 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.1 1.0 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.1 0.3 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.1 0.4 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.1 0.6 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 0.6 GO:1903351 response to dopamine(GO:1903350) cellular response to dopamine(GO:1903351)
0.1 0.5 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.1 0.5 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.1 1.8 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 0.6 GO:0036158 outer dynein arm assembly(GO:0036158)
0.0 0.8 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0 0.7 GO:0090344 negative regulation of cell aging(GO:0090344)
0.0 0.3 GO:0060372 regulation of atrial cardiac muscle cell membrane repolarization(GO:0060372)
0.0 0.4 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0 0.3 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 0.4 GO:0048671 negative regulation of collateral sprouting(GO:0048671)
0.0 0.4 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.0 0.2 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.7 GO:0015909 long-chain fatty acid transport(GO:0015909)
0.0 0.8 GO:0051489 regulation of filopodium assembly(GO:0051489)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.2 1.0 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 0.6 GO:0045251 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.1 1.8 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 0.6 GO:0034715 U7 snRNP(GO:0005683) pICln-Sm protein complex(GO:0034715)
0.1 1.1 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.1 0.7 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 2.0 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 0.6 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.6 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 1.1 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.5 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.1 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.0 0.6 GO:0016592 mediator complex(GO:0016592)
0.0 0.4 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.0 2.9 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 0.8 GO:0016459 myosin complex(GO:0016459)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 5.3 GO:0019841 retinol binding(GO:0019841)
0.7 2.0 GO:0030156 benzodiazepine receptor binding(GO:0030156)
0.3 0.8 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.2 1.0 GO:0070404 NADH binding(GO:0070404)
0.2 0.5 GO:0071723 lipopeptide binding(GO:0071723)
0.1 1.1 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 0.7 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.1 1.0 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.1 0.5 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.1 0.3 GO:0017099 very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099)
0.1 0.6 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 1.1 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.1 0.2 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.1 0.8 GO:0003988 acetyl-CoA C-acyltransferase activity(GO:0003988)
0.0 0.7 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.8 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.3 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.0 0.3 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.6 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.8 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.0 1.1 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 0.6 GO:0009055 electron carrier activity(GO:0009055)
0.0 0.8 GO:0030507 spectrin binding(GO:0030507)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.9 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.8 PID_NETRIN_PATHWAY Netrin-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 2.1 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 1.1 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 0.8 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 0.8 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.1 0.6 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.5 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 1.0 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 1.3 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.6 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 1.2 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 0.4 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.3 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.5 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.8 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling