Motif ID: Bhlhe40

Z-value: 0.571


Transcription factors associated with Bhlhe40:

Gene SymbolEntrez IDGene Name
Bhlhe40 ENSMUSG00000030103.5 Bhlhe40

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Bhlhe40mm10_v2_chr6_+_108660616_108660682-0.603.0e-05Click!


Activity profile for motif Bhlhe40.

activity profile for motif Bhlhe40


Sorted Z-values histogram for motif Bhlhe40

Sorted Z-values for motif Bhlhe40



Network of associatons between targets according to the STRING database.



First level regulatory network of Bhlhe40

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_148039097 3.803 ENSMUST00000141283.1
Mthfr
5,10-methylenetetrahydrofolate reductase
chr4_+_148039035 3.798 ENSMUST00000097788.4
Mthfr
5,10-methylenetetrahydrofolate reductase
chr7_+_121707189 3.575 ENSMUST00000065310.2
1700069B07Rik
RIKEN cDNA 1700069B07 gene
chr4_-_148038769 3.026 ENSMUST00000030879.5
ENSMUST00000137724.1
Clcn6

chloride channel 6

chr16_-_44139630 1.546 ENSMUST00000137557.1
ENSMUST00000147025.1
Atp6v1a

ATPase, H+ transporting, lysosomal V1 subunit A

chr5_-_123572976 1.495 ENSMUST00000031388.8
Vps33a
vacuolar protein sorting 33A (yeast)
chr7_+_35802593 1.471 ENSMUST00000052454.2
E130304I02Rik
RIKEN cDNA E130304I02 gene
chr16_-_44139003 1.462 ENSMUST00000124102.1
Atp6v1a
ATPase, H+ transporting, lysosomal V1 subunit A
chr16_+_8830093 1.355 ENSMUST00000023150.5
1810013L24Rik
RIKEN cDNA 1810013L24 gene
chr5_+_65199691 1.326 ENSMUST00000041892.8
Wdr19
WD repeat domain 19
chr11_+_97450136 1.194 ENSMUST00000107601.1
Arhgap23
Rho GTPase activating protein 23
chr11_+_55204319 1.070 ENSMUST00000108872.2
ENSMUST00000147506.1
ENSMUST00000020499.7
Slc36a1


solute carrier family 36 (proton/amino acid symporter), member 1


chr12_-_3426700 1.050 ENSMUST00000180149.1
1110002L01Rik
RIKEN cDNA 1110002L01 gene
chr11_-_75454656 1.009 ENSMUST00000173320.1
Wdr81
WD repeat domain 81
chr16_+_5233615 0.924 ENSMUST00000100196.2
ENSMUST00000049207.8
Alg1

asparagine-linked glycosylation 1 (beta-1,4-mannosyltransferase)

chr12_+_86947343 0.902 ENSMUST00000038369.4
2310044G17Rik
RIKEN cDNA 2310044G17 gene
chr4_-_141790891 0.898 ENSMUST00000038014.4
ENSMUST00000153880.1
Dnajc16

DnaJ (Hsp40) homolog, subfamily C, member 16

chrX_-_7188713 0.885 ENSMUST00000004428.7
Clcn5
chloride channel 5
chr1_+_5083105 0.855 ENSMUST00000044369.7
Atp6v1h
ATPase, H+ transporting, lysosomal V1 subunit H
chr7_-_35802968 0.837 ENSMUST00000061586.4
Zfp507
zinc finger protein 507
chr10_-_80139347 0.812 ENSMUST00000105369.1
Dos
downstream of Stk11
chr18_-_20896078 0.755 ENSMUST00000025177.6
ENSMUST00000097658.1
Trappc8

trafficking protein particle complex 8

chr2_+_30286406 0.728 ENSMUST00000138666.1
ENSMUST00000113634.2
Nup188

nucleoporin 188

chr16_+_5050012 0.726 ENSMUST00000052449.5
Ubn1
ubinuclein 1
chr18_+_31609512 0.719 ENSMUST00000164667.1
B930094E09Rik
RIKEN cDNA B930094E09 gene
chr8_+_85037151 0.698 ENSMUST00000166592.1
Tnpo2
transportin 2 (importin 3, karyopherin beta 2b)
chr16_-_44139196 0.688 ENSMUST00000063661.6
ENSMUST00000114666.2
Atp6v1a

ATPase, H+ transporting, lysosomal V1 subunit A

chr8_+_85036906 0.684 ENSMUST00000093360.4
Tnpo2
transportin 2 (importin 3, karyopherin beta 2b)
chrX_-_152327430 0.641 ENSMUST00000181635.1
ENSMUST00000141922.1
ENSMUST00000154085.1
ENSMUST00000148326.1
ENSMUST00000135115.1
ENSMUST00000149098.1
2900056M20Rik





RIKEN cDNA 2900056M20 gene





chr9_+_108002501 0.637 ENSMUST00000035214.4
ENSMUST00000175874.1
Ip6k1

inositol hexaphosphate kinase 1

chr6_+_17693965 0.624 ENSMUST00000115419.1
St7
suppression of tumorigenicity 7
chr2_-_37422869 0.607 ENSMUST00000112936.1
ENSMUST00000112934.1
Rc3h2

ring finger and CCCH-type zinc finger domains 2

chr16_-_92466081 0.588 ENSMUST00000060005.8
Rcan1
regulator of calcineurin 1
chr6_+_72097561 0.573 ENSMUST00000069994.4
ENSMUST00000114112.1
St3gal5

ST3 beta-galactoside alpha-2,3-sialyltransferase 5

chr3_-_10440054 0.565 ENSMUST00000099223.4
ENSMUST00000029047.6
Snx16

sorting nexin 16

chr7_-_126583523 0.564 ENSMUST00000125508.1
ENSMUST00000147086.1
ENSMUST00000150587.1
Cln3


ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease)


chr5_+_123252087 0.525 ENSMUST00000121964.1
Wdr66
WD repeat domain 66
chr7_+_27195781 0.524 ENSMUST00000108379.1
ENSMUST00000179391.1
BC024978

cDNA sequence BC024978

chr6_+_17693905 0.502 ENSMUST00000115420.1
St7
suppression of tumorigenicity 7
chr7_+_128744870 0.501 ENSMUST00000042942.8
Sec23ip
Sec23 interacting protein
chr17_-_12769605 0.483 ENSMUST00000024599.7
Igf2r
insulin-like growth factor 2 receptor
chrX_-_136203637 0.463 ENSMUST00000151592.1
ENSMUST00000131510.1
ENSMUST00000066819.4
Tceal5


transcription elongation factor A (SII)-like 5


chr2_+_166805506 0.460 ENSMUST00000099078.3
Arfgef2
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
chr19_+_29522263 0.454 ENSMUST00000043610.6
ENSMUST00000162184.1
C030046E11Rik

RIKEN cDNA C030046E11 gene

chr8_-_84846860 0.449 ENSMUST00000003912.6
Calr
calreticulin
chr4_-_48473403 0.432 ENSMUST00000164866.1
ENSMUST00000030030.8
Tex10

testis expressed gene 10

chr3_+_96727611 0.421 ENSMUST00000029740.9
Rnf115
ring finger protein 115
chr2_+_30286383 0.411 ENSMUST00000064447.5
Nup188
nucleoporin 188
chr8_+_3500451 0.408 ENSMUST00000004683.6
ENSMUST00000160338.1
Mcoln1

mucolipin 1

chr2_-_30286312 0.398 ENSMUST00000100219.3
Dolk
dolichol kinase
chr6_+_17694005 0.375 ENSMUST00000081635.6
ENSMUST00000052113.5
St7

suppression of tumorigenicity 7

chr18_-_31609893 0.359 ENSMUST00000060396.6
Slc25a46
solute carrier family 25, member 46
chr14_+_26579535 0.357 ENSMUST00000037585.7
Dennd6a
DENN/MADD domain containing 6A
chr9_-_97111117 0.349 ENSMUST00000085206.4
Slc25a36
solute carrier family 25, member 36
chr8_+_111033890 0.347 ENSMUST00000034441.7
Aars
alanyl-tRNA synthetase
chr4_-_137048695 0.328 ENSMUST00000049583.7
Zbtb40
zinc finger and BTB domain containing 40
chrX_+_153832225 0.300 ENSMUST00000148708.1
ENSMUST00000123264.1
ENSMUST00000049999.8
Spin2c


spindlin family, member 2C


chr3_-_95106907 0.293 ENSMUST00000107233.2
Pip5k1a
phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha
chr2_-_37703845 0.292 ENSMUST00000155237.1
Strbp
spermatid perinuclear RNA binding protein
chr12_-_79296266 0.287 ENSMUST00000021547.6
Zfyve26
zinc finger, FYVE domain containing 26
chr11_+_75348433 0.286 ENSMUST00000044530.2
Smyd4
SET and MYND domain containing 4
chr2_-_160619971 0.284 ENSMUST00000109473.1
Gm14221
predicted gene 14221
chr13_-_48625571 0.280 ENSMUST00000035824.9
Ptpdc1
protein tyrosine phosphatase domain containing 1
chr9_-_44361625 0.269 ENSMUST00000034644.8
Vps11
vacuolar protein sorting 11 (yeast)
chr3_-_95106779 0.251 ENSMUST00000005768.7
ENSMUST00000107232.2
ENSMUST00000107236.2
Pip5k1a


phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha


chr6_+_17694167 0.245 ENSMUST00000115418.1
St7
suppression of tumorigenicity 7
chr16_-_5049882 0.231 ENSMUST00000023189.7
ENSMUST00000115844.1
Glyr1

glyoxylate reductase 1 homolog (Arabidopsis)

chr11_+_3649494 0.228 ENSMUST00000093389.2
Morc2a
microrchidia 2A
chr8_+_25601591 0.225 ENSMUST00000155861.1
Whsc1l1
Wolf-Hirschhorn syndrome candidate 1-like 1 (human)
chr6_-_35133731 0.208 ENSMUST00000114993.2
ENSMUST00000114989.2
ENSMUST00000044163.6
Cnot4


CCR4-NOT transcription complex, subunit 4


chr1_-_75219245 0.207 ENSMUST00000079464.6
Tuba4a
tubulin, alpha 4A
chr11_+_49203465 0.206 ENSMUST00000150284.1
ENSMUST00000109197.1
ENSMUST00000151228.1
Zfp62


zinc finger protein 62


chr1_+_152766540 0.186 ENSMUST00000077755.5
ENSMUST00000097536.4
Arpc5

actin related protein 2/3 complex, subunit 5

chr11_-_70239794 0.164 ENSMUST00000040428.3
Rnasek
ribonuclease, RNase K
chr11_-_110095937 0.156 ENSMUST00000106664.3
ENSMUST00000046223.7
ENSMUST00000106662.1
Abca8a


ATP-binding cassette, sub-family A (ABC1), member 8a


chr10_-_18023229 0.153 ENSMUST00000020002.7
Abracl
ABRA C-terminal like
chr3_+_89202916 0.152 ENSMUST00000077367.4
ENSMUST00000167998.1
Gba

glucosidase, beta, acid

chr7_-_90475971 0.148 ENSMUST00000032843.7
Tmem126b
transmembrane protein 126B
chr5_-_137533170 0.117 ENSMUST00000168746.1
ENSMUST00000170293.1
Gnb2

guanine nucleotide binding protein (G protein), beta 2

chr11_-_110095974 0.116 ENSMUST00000100287.2
Abca8a
ATP-binding cassette, sub-family A (ABC1), member 8a
chr17_+_70561739 0.080 ENSMUST00000097288.2
Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr9_+_59539643 0.074 ENSMUST00000026262.6
Hexa
hexosaminidase A
chr12_-_84450944 0.070 ENSMUST00000085192.5
Aldh6a1
aldehyde dehydrogenase family 6, subfamily A1
chr6_+_116338013 0.069 ENSMUST00000079012.6
ENSMUST00000101032.3
March8

membrane-associated ring finger (C3HC4) 8

chr7_+_82648595 0.066 ENSMUST00000141726.1
ENSMUST00000179489.1
ENSMUST00000039881.3
Eftud1


elongation factor Tu GTP binding domain containing 1


chr12_-_91590009 0.043 ENSMUST00000021345.6
Gtf2a1
general transcription factor II A, 1
chr3_-_90052463 0.038 ENSMUST00000029553.9
ENSMUST00000064639.8
ENSMUST00000090908.6
Ubap2l


ubiquitin associated protein 2-like


chr19_-_33392255 0.035 ENSMUST00000096114.5
ENSMUST00000163093.1
Rnls

renalase, FAD-dependent amine oxidase

chr4_+_134468320 0.013 ENSMUST00000030636.4
ENSMUST00000127279.1
ENSMUST00000105867.1
Stmn1


stathmin 1


chr11_-_52000748 0.009 ENSMUST00000109086.1
Ube2b
ubiquitin-conjugating enzyme E2B
chrX_+_136270253 0.007 ENSMUST00000178632.1
ENSMUST00000053540.4
Ngfrap1

nerve growth factor receptor (TNFRSF16) associated protein 1

chr11_+_49203285 0.005 ENSMUST00000109198.1
ENSMUST00000137061.2
Zfp62

zinc finger protein 62


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 7.6 GO:0070829 heterochromatin maintenance(GO:0070829)
0.3 1.3 GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830) myotome development(GO:0061055)
0.2 1.1 GO:0090521 glomerular visceral epithelial cell migration(GO:0090521)
0.2 3.7 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.2 1.1 GO:0015808 L-alanine transport(GO:0015808)
0.1 0.4 GO:2000510 positive regulation of dendritic cell chemotaxis(GO:2000510)
0.1 0.6 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
0.1 1.5 GO:0035751 regulation of lysosomal lumen pH(GO:0035751)
0.1 1.4 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.1 0.3 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.1 0.8 GO:0030242 pexophagy(GO:0030242)
0.1 0.3 GO:0072531 pyrimidine-containing compound transmembrane transport(GO:0072531)
0.1 3.9 GO:1902476 chloride transmembrane transport(GO:1902476)
0.1 0.9 GO:0007035 vacuolar acidification(GO:0007035)
0.1 0.6 GO:0061470 T follicular helper cell differentiation(GO:0061470)
0.1 0.4 GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin(GO:2000049)
0.1 0.6 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.5 GO:0001675 acrosome assembly(GO:0001675)
0.0 0.3 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.0 0.2 GO:1903061 regulation of protein lipidation(GO:1903059) positive regulation of protein lipidation(GO:1903061) positive regulation of neuronal action potential(GO:1904457)
0.0 0.6 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.0 0.6 GO:0006622 protein targeting to lysosome(GO:0006622)
0.0 0.4 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 0.4 GO:0090148 membrane fission(GO:0090148)
0.0 0.7 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)
0.0 0.1 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.0 0.5 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.5 GO:0097178 ruffle assembly(GO:0097178)
0.0 0.4 GO:0097352 autophagosome maturation(GO:0097352)
0.0 0.1 GO:0006689 ganglioside catabolic process(GO:0006689)
0.0 0.1 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
0.0 0.2 GO:0051639 actin filament network formation(GO:0051639)
0.0 1.0 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.6 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 0.0 GO:0071873 response to norepinephrine(GO:0071873)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.6 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.3 1.8 GO:0033263 CORVET complex(GO:0033263)
0.2 1.1 GO:0044611 nuclear pore inner ring(GO:0044611)
0.1 1.3 GO:0030991 intraciliary transport particle A(GO:0030991)
0.1 0.5 GO:0032280 symmetric synapse(GO:0032280)
0.1 0.6 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.1 0.4 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.0 0.8 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.5 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.2 GO:0043202 lysosomal lumen(GO:0043202)
0.0 0.5 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 5.9 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 0.5 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 0.2 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.4 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 7.6 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.4 1.1 GO:0015173 hydrogen:amino acid symporter activity(GO:0005280) aromatic amino acid transmembrane transporter activity(GO:0015173)
0.2 3.9 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.2 4.6 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.2 0.6 GO:0000832 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.1 0.3 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.1 0.4 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.1 0.6 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.1 0.2 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.1 0.5 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.1 0.5 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 1.4 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 0.2 GO:0004348 glucosylceramidase activity(GO:0004348)
0.0 1.1 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.9 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 0.5 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.6 GO:0008373 sialyltransferase activity(GO:0008373)
0.0 0.1 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.0 0.3 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)
0.0 0.1 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.4 GO:0050681 androgen receptor binding(GO:0050681)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.6 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.6 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.1 0.4 REACTOME_TRANSFERRIN_ENDOCYTOSIS_AND_RECYCLING Genes involved in Transferrin endocytosis and recycling
0.1 7.2 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 1.3 REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.4 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 1.1 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.2 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.3 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.5 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis