Motif ID: Maff

Z-value: 0.631


Transcription factors associated with Maff:

Gene SymbolEntrez IDGene Name
Maff ENSMUSG00000042622.7 Maff

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Maffmm10_v2_chr15_+_79348061_793481540.251.1e-01Click!


Activity profile for motif Maff.

activity profile for motif Maff


Sorted Z-values histogram for motif Maff

Sorted Z-values for motif Maff



Network of associatons between targets according to the STRING database.



First level regulatory network of Maff

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_+_48261427 4.636 ENSMUST00000021810.1
Id4
inhibitor of DNA binding 4
chr17_-_25570678 3.786 ENSMUST00000025003.3
ENSMUST00000173447.1
Sox8

SRY-box containing gene 8

chr4_-_143299498 3.240 ENSMUST00000030317.7
Pdpn
podoplanin
chr4_-_143299463 3.171 ENSMUST00000119654.1
Pdpn
podoplanin
chr16_-_22439719 3.029 ENSMUST00000079601.6
Etv5
ets variant gene 5
chr7_-_44997535 2.232 ENSMUST00000124232.1
ENSMUST00000003290.4
Bcl2l12

BCL2-like 12 (proline rich)

chr9_-_111690313 1.919 ENSMUST00000035083.7
Stac
src homology three (SH3) and cysteine rich domain
chr11_-_109473598 1.903 ENSMUST00000070152.5
Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr5_-_135251209 1.641 ENSMUST00000062572.2
Fzd9
frizzled homolog 9 (Drosophila)
chr18_+_60963517 1.616 ENSMUST00000115295.2
ENSMUST00000039904.6
Camk2a

calcium/calmodulin-dependent protein kinase II alpha

chr2_-_69206133 1.570 ENSMUST00000112320.1
Spc25
SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr2_-_69206146 1.550 ENSMUST00000127243.1
ENSMUST00000149643.1
ENSMUST00000167875.2
ENSMUST00000005365.8
Spc25



SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)



chr2_-_127831817 1.389 ENSMUST00000028858.7
Bub1
budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)
chr10_-_88605017 1.354 ENSMUST00000119185.1
ENSMUST00000121629.1
Mybpc1

myosin binding protein C, slow-type

chr18_+_4921662 1.233 ENSMUST00000143254.1
Svil
supervillin
chr13_-_23710714 1.218 ENSMUST00000091707.6
ENSMUST00000006787.7
ENSMUST00000091706.6
Hfe


hemochromatosis


chr7_+_84528964 1.186 ENSMUST00000180387.1
Gm2115
predicted gene 2115
chr5_+_7179299 1.070 ENSMUST00000179460.1
Tubb4b-ps1
tubulin, beta 4B class IVB, pseudogene 1
chr4_+_141239499 0.902 ENSMUST00000141834.2
Arhgef19
Rho guanine nucleotide exchange factor (GEF) 19
chr1_+_136018062 0.839 ENSMUST00000117950.1
Tmem9
transmembrane protein 9
chr1_+_136017967 0.816 ENSMUST00000063719.8
ENSMUST00000118832.1
Tmem9

transmembrane protein 9

chr5_+_110839973 0.745 ENSMUST00000066160.1
Chek2
checkpoint kinase 2
chr17_+_86963279 0.743 ENSMUST00000139344.1
Rhoq
ras homolog gene family, member Q
chr9_+_65214690 0.737 ENSMUST00000069000.7
Parp16
poly (ADP-ribose) polymerase family, member 16
chr14_+_20929416 0.705 ENSMUST00000022369.7
Vcl
vinculin
chr3_+_127791374 0.641 ENSMUST00000171621.1
Tifa
TRAF-interacting protein with forkhead-associated domain
chr5_+_106964319 0.640 ENSMUST00000031221.5
ENSMUST00000117196.2
ENSMUST00000076467.6
Cdc7


cell division cycle 7 (S. cerevisiae)


chr18_+_33464163 0.619 ENSMUST00000097634.3
Gm10549
predicted gene 10549
chr3_+_28805436 0.619 ENSMUST00000043867.5
Rpl22l1
ribosomal protein L22 like 1
chr11_+_76945719 0.552 ENSMUST00000125145.1
Blmh
bleomycin hydrolase
chr7_-_4684963 0.551 ENSMUST00000079970.4
Hspbp1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr15_+_3270767 0.524 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
Sepp1



selenoprotein P, plasma, 1



chr5_+_8056527 0.512 ENSMUST00000148633.1
Sri
sorcin
chr5_+_104435112 0.500 ENSMUST00000031243.8
ENSMUST00000086833.6
ENSMUST00000112748.1
ENSMUST00000112746.1
ENSMUST00000145084.1
ENSMUST00000132457.1
Spp1





secreted phosphoprotein 1





chr8_+_46739745 0.451 ENSMUST00000034041.7
Irf2
interferon regulatory factor 2
chr19_+_56722372 0.448 ENSMUST00000038949.4
Adrb1
adrenergic receptor, beta 1
chr2_-_130397525 0.408 ENSMUST00000028897.7
Cpxm1
carboxypeptidase X 1 (M14 family)
chr4_-_136886187 0.322 ENSMUST00000046384.8
C1qb
complement component 1, q subcomponent, beta polypeptide
chr7_-_13037627 0.316 ENSMUST00000125964.1
Ube2m
ubiquitin-conjugating enzyme E2M
chr4_-_25281752 0.316 ENSMUST00000038705.7
Ufl1
UFM1 specific ligase 1
chr11_+_75651504 0.302 ENSMUST00000069057.6
Myo1c
myosin IC
chr19_-_57197556 0.298 ENSMUST00000099294.2
Ablim1
actin-binding LIM protein 1
chr17_+_27839974 0.294 ENSMUST00000071006.7
Snrpc
U1 small nuclear ribonucleoprotein C
chr5_-_121618865 0.286 ENSMUST00000041252.6
ENSMUST00000111776.1
Acad12

acyl-Coenzyme A dehydrogenase family, member 12

chr3_+_96161981 0.276 ENSMUST00000054356.9
Mtmr11
myotubularin related protein 11
chr1_+_75382114 0.270 ENSMUST00000113590.1
ENSMUST00000148515.1
Speg

SPEG complex locus

chr7_-_110862944 0.262 ENSMUST00000033050.3
Lyve1
lymphatic vessel endothelial hyaluronan receptor 1
chr4_-_25281801 0.257 ENSMUST00000102994.3
Ufl1
UFM1 specific ligase 1
chr1_-_120074023 0.240 ENSMUST00000056089.7
Tmem37
transmembrane protein 37
chr10_-_121626316 0.227 ENSMUST00000039810.7
Xpot
exportin, tRNA (nuclear export receptor for tRNAs)
chr4_-_139352538 0.215 ENSMUST00000102503.3
Mrto4
MRT4, mRNA turnover 4, homolog (S. cerevisiae)
chr9_-_57765845 0.199 ENSMUST00000065330.6
Clk3
CDC-like kinase 3
chr1_+_72307413 0.199 ENSMUST00000027379.8
Xrcc5
X-ray repair complementing defective repair in Chinese hamster cells 5
chr19_-_4042165 0.195 ENSMUST00000042700.9
Gstp2
glutathione S-transferase, pi 2
chr4_-_139352298 0.191 ENSMUST00000030513.6
ENSMUST00000155257.1
Mrto4

MRT4, mRNA turnover 4, homolog (S. cerevisiae)

chr17_+_26138661 0.176 ENSMUST00000074370.3
ENSMUST00000118904.2
ENSMUST00000163421.1
Axin1


axin 1


chr4_+_102421518 0.167 ENSMUST00000106904.2
Pde4b
phosphodiesterase 4B, cAMP specific
chr7_+_16944645 0.141 ENSMUST00000094807.5
Pnmal2
PNMA-like 2
chr10_+_26078255 0.137 ENSMUST00000041011.3
Gm9767
predicted gene 9767
chr8_-_12672135 0.137 ENSMUST00000000776.8
Tubgcp3
tubulin, gamma complex associated protein 3
chr5_+_103754560 0.082 ENSMUST00000153165.1
ENSMUST00000031256.5
Aff1

AF4/FMR2 family, member 1

chr19_+_58728887 0.065 ENSMUST00000048644.5
Pnliprp1
pancreatic lipase related protein 1
chr1_-_88205674 0.063 ENSMUST00000119972.2
Dnajb3
DnaJ (Hsp40) homolog, subfamily B, member 3
chr4_-_94556737 0.040 ENSMUST00000030313.8
Caap1
caspase activity and apoptosis inhibitor 1
chr12_-_80436571 0.021 ENSMUST00000054145.6
Dcaf5
DDB1 and CUL4 associated factor 5
chr3_-_59262825 0.018 ENSMUST00000050360.7
P2ry12
purinergic receptor P2Y, G-protein coupled 12

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 6.4 GO:1901731 positive regulation of platelet aggregation(GO:1901731)
1.3 3.8 GO:0072034 renal vesicle induction(GO:0072034)
1.2 4.6 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
0.6 3.0 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.5 1.6 GO:1990523 bone regeneration(GO:1990523)
0.5 1.4 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
0.4 1.2 GO:0002725 negative regulation of antigen processing and presentation(GO:0002578) negative regulation of T cell cytokine production(GO:0002725)
0.3 1.4 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.2 2.2 GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166)
0.2 0.7 GO:0070213 protein auto-ADP-ribosylation(GO:0070213)
0.2 0.7 GO:1903463 regulation of mitotic cell cycle DNA replication(GO:1903463)
0.1 0.4 GO:1900133 renin secretion into blood stream(GO:0002001) regulation of renin secretion into blood stream(GO:1900133)
0.1 0.5 GO:0035937 androgen catabolic process(GO:0006710) estrogen secretion(GO:0035937) estradiol secretion(GO:0035938) regulation of estrogen secretion(GO:2000861) regulation of estradiol secretion(GO:2000864)
0.1 1.6 GO:0099628 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
0.1 0.6 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.1 0.6 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.1 0.6 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.1 0.5 GO:0055118 negative regulation of cardiac muscle contraction(GO:0055118)
0.1 0.3 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.1 0.2 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.1 2.1 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.0 0.2 GO:0071475 cellular hyperosmotic salinity response(GO:0071475) negative regulation of t-circle formation(GO:1904430)
0.0 0.2 GO:0048319 axial mesoderm morphogenesis(GO:0048319)
0.0 0.7 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.0 0.3 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.3 GO:0006027 glycosaminoglycan catabolic process(GO:0006027)
0.0 3.3 GO:0007052 mitotic spindle organization(GO:0007052)
0.0 0.7 GO:1903077 negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.0 0.3 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0 0.3 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 0.3 GO:0045116 protein neddylation(GO:0045116)
0.0 0.4 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 1.9 GO:0015718 monocarboxylic acid transport(GO:0015718)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 6.4 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.5 1.6 GO:0099573 glutamatergic postsynaptic density(GO:0099573)
0.5 3.1 GO:0031262 Ndc80 complex(GO:0031262)
0.5 1.4 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.2 1.2 GO:1990357 terminal web(GO:1990357)
0.2 1.4 GO:0005859 muscle myosin complex(GO:0005859)
0.2 0.5 GO:0042584 chromaffin granule membrane(GO:0042584)
0.1 0.3 GO:0045160 myosin I complex(GO:0045160)
0.1 1.6 GO:0031527 filopodium membrane(GO:0031527)
0.1 0.2 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.1 0.7 GO:0005916 fascia adherens(GO:0005916)
0.0 0.2 GO:0043564 Ku70:Ku80 complex(GO:0043564)
0.0 0.7 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 1.2 GO:0043034 costamere(GO:0043034)
0.0 0.3 GO:0000243 commitment complex(GO:0000243)
0.0 0.1 GO:0005827 equatorial microtubule organizing center(GO:0000923) polar microtubule(GO:0005827)
0.0 0.2 GO:1990909 Wnt signalosome(GO:1990909)
0.0 3.8 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 0.6 GO:0045171 intercellular bridge(GO:0045171)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 6.4 GO:0015250 water channel activity(GO:0015250)
0.3 1.4 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.2 0.6 GO:0071568 UFM1 transferase activity(GO:0071568)
0.1 0.4 GO:0051379 epinephrine binding(GO:0051379)
0.1 1.2 GO:0039706 co-receptor binding(GO:0039706)
0.1 1.6 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 1.6 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 0.7 GO:0005522 profilin binding(GO:0005522)
0.1 0.7 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 1.9 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 0.3 GO:0070739 NEDD8 transferase activity(GO:0019788) protein-glutamic acid ligase activity(GO:0070739)
0.0 3.7 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 0.7 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.3 GO:1990446 U1 snRNP binding(GO:1990446)
0.0 4.6 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 2.4 GO:0002039 p53 binding(GO:0002039)
0.0 0.5 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.4 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.3 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.2 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.0 0.3 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.0 0.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.1 GO:0051011 microtubule minus-end binding(GO:0051011)
0.0 0.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.6 GO:0004177 aminopeptidase activity(GO:0004177)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.0 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 1.6 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 1.6 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.4 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.3 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.7 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.7 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 0.5 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.4 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.7 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.0 PID_AR_PATHWAY Coregulation of Androgen receptor activity

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 1.6 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 1.4 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 0.3 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 4.5 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.4 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.7 REACTOME_MUSCLE_CONTRACTION Genes involved in Muscle contraction
0.0 0.3 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.5 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 1.6 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.6 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex
0.0 0.2 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.1 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.2 REACTOME_INTEGRATION_OF_PROVIRUS Genes involved in Integration of provirus
0.0 0.3 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling