Motif ID: Hes5_Hes7

Z-value: 1.433

Transcription factors associated with Hes5_Hes7:

Gene SymbolEntrez IDGene Name
Hes5 ENSMUSG00000048001.7 Hes5
Hes7 ENSMUSG00000023781.2 Hes7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hes5mm10_v2_chr4_+_154960915_1549609300.645.4e-06Click!
Hes7mm10_v2_chr11_+_69120404_69120404-0.086.4e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Hes5_Hes7

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_12026237 45.881 ENSMUST00000150972.1
Grb10
growth factor receptor bound protein 10
chr11_-_12026732 44.638 ENSMUST00000143915.1
Grb10
growth factor receptor bound protein 10
chr2_+_73271925 17.202 ENSMUST00000090813.5
Sp9
trans-acting transcription factor 9
chr10_-_87493651 15.155 ENSMUST00000020243.7
Ascl1
achaete-scute complex homolog 1 (Drosophila)
chr2_+_163203072 11.845 ENSMUST00000109428.2
Tox2
TOX high mobility group box family member 2
chr13_+_51846673 8.711 ENSMUST00000021903.2
Gadd45g
growth arrest and DNA-damage-inducible 45 gamma
chr4_-_132757162 6.832 ENSMUST00000030709.8
Smpdl3b
sphingomyelin phosphodiesterase, acid-like 3B
chr12_-_56536895 6.458 ENSMUST00000001536.8
Nkx2-1
NK2 homeobox 1
chr15_+_72913357 6.228 ENSMUST00000166418.2
Gm3150
predicted gene 3150
chr13_+_108316332 6.183 ENSMUST00000051594.5
Depdc1b
DEP domain containing 1B
chr13_+_108316395 6.071 ENSMUST00000171178.1
Depdc1b
DEP domain containing 1B
chr4_+_137913471 5.829 ENSMUST00000151110.1
Ece1
endothelin converting enzyme 1
chr6_+_4755327 5.819 ENSMUST00000176551.1
Peg10
paternally expressed 10
chr12_+_109459843 5.540 ENSMUST00000173812.1
Dlk1
delta-like 1 homolog (Drosophila)
chr12_+_109549157 5.169 ENSMUST00000128458.1
ENSMUST00000150851.1
Meg3

maternally expressed 3

chr9_+_64121501 4.750 ENSMUST00000118215.1
Lctl
lactase-like
chr1_+_72824482 4.675 ENSMUST00000047328.4
Igfbp2
insulin-like growth factor binding protein 2
chr9_-_36726374 4.277 ENSMUST00000172702.2
ENSMUST00000172742.1
ENSMUST00000034625.5
Chek1


checkpoint kinase 1


chr10_+_79682169 3.799 ENSMUST00000020550.5
Cdc34
cell division cycle 34
chr10_+_79682304 3.639 ENSMUST00000166603.1
Cdc34
cell division cycle 34
chr8_-_87804411 3.511 ENSMUST00000165770.2
Zfp423
zinc finger protein 423
chr8_+_119446719 2.731 ENSMUST00000098363.3
Necab2
N-terminal EF-hand calcium binding protein 2
chr11_+_59306920 2.365 ENSMUST00000000128.3
ENSMUST00000108783.3
Wnt9a

wingless-type MMTV integration site 9A

chr9_+_107587711 2.274 ENSMUST00000010192.5
Ifrd2
interferon-related developmental regulator 2
chr2_-_92370999 2.194 ENSMUST00000176810.1
ENSMUST00000090582.4
Gyltl1b

glycosyltransferase-like 1B

chr6_+_91157373 2.133 ENSMUST00000155007.1
Hdac11
histone deacetylase 11
chr17_-_24960620 2.066 ENSMUST00000024981.7
Hn1l
hematological and neurological expressed 1-like
chr11_-_59787636 2.034 ENSMUST00000125307.1
Pld6
phospholipase D family, member 6
chr1_-_75219245 1.981 ENSMUST00000079464.6
Tuba4a
tubulin, alpha 4A
chr1_+_131962941 1.744 ENSMUST00000177943.1
Slc45a3
solute carrier family 45, member 3
chr11_-_50325599 1.694 ENSMUST00000179865.1
ENSMUST00000020637.8
Canx

calnexin

chr17_+_35861318 1.667 ENSMUST00000074259.8
ENSMUST00000174873.1
Nrm

nurim (nuclear envelope membrane protein)

chr8_+_60632856 1.624 ENSMUST00000160719.1
Mfap3l
microfibrillar-associated protein 3-like
chr2_-_92371039 1.598 ENSMUST00000068586.6
Gyltl1b
glycosyltransferase-like 1B
chr8_+_60632818 1.581 ENSMUST00000161421.1
Mfap3l
microfibrillar-associated protein 3-like
chr11_+_120491840 1.528 ENSMUST00000026899.3
Slc25a10
solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10
chr13_+_35741313 1.524 ENSMUST00000163595.2
Cdyl
chromodomain protein, Y chromosome-like
chr5_+_128601106 1.489 ENSMUST00000117102.2
Fzd10
frizzled homolog 10 (Drosophila)
chr2_-_92370968 1.368 ENSMUST00000176774.1
Gyltl1b
glycosyltransferase-like 1B
chr11_+_4637734 1.194 ENSMUST00000109930.2
ENSMUST00000070257.7
Ascc2

activating signal cointegrator 1 complex subunit 2

chr15_+_39076885 1.135 ENSMUST00000067072.3
Cthrc1
collagen triple helix repeat containing 1
chr11_+_54866413 1.082 ENSMUST00000117710.1
Hint1
histidine triad nucleotide binding protein 1
chr4_-_43562397 1.067 ENSMUST00000030187.7
Tln1
talin 1
chr16_-_33967032 1.063 ENSMUST00000023510.6
Umps
uridine monophosphate synthetase
chr3_-_95855753 0.984 ENSMUST00000161476.1
Prpf3
PRP3 pre-mRNA processing factor 3 homolog (yeast)
chr4_+_11191354 0.937 ENSMUST00000170901.1
Ccne2
cyclin E2
chr3_-_95882193 0.883 ENSMUST00000159863.1
ENSMUST00000159739.1
ENSMUST00000036418.3
Gm129


predicted gene 129


chr3_-_95855860 0.833 ENSMUST00000015892.7
Prpf3
PRP3 pre-mRNA processing factor 3 homolog (yeast)
chr14_+_59201418 0.773 ENSMUST00000140136.2
ENSMUST00000142326.1
Rcbtb1

regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1

chr7_-_65371210 0.769 ENSMUST00000102592.3
Tjp1
tight junction protein 1
chr11_+_54866374 0.761 ENSMUST00000020504.5
Hint1
histidine triad nucleotide binding protein 1
chr5_+_147860615 0.741 ENSMUST00000031654.6
Pomp
proteasome maturation protein
chr4_-_133756769 0.708 ENSMUST00000008024.6
Arid1a
AT rich interactive domain 1A (SWI-like)
chr11_-_78165521 0.686 ENSMUST00000017530.3
Traf4
TNF receptor associated factor 4
chr3_-_95882031 0.635 ENSMUST00000161994.1
Gm129
predicted gene 129
chr3_-_90052463 0.632 ENSMUST00000029553.9
ENSMUST00000064639.8
ENSMUST00000090908.6
Ubap2l


ubiquitin associated protein 2-like


chr14_+_59201209 0.622 ENSMUST00000173547.1
ENSMUST00000043227.6
ENSMUST00000022551.7
Rcbtb1


regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1


chr2_-_150255591 0.622 ENSMUST00000063463.5
Gm21994
predicted gene 21994
chr7_-_65370908 0.572 ENSMUST00000032729.6
Tjp1
tight junction protein 1
chr11_+_3963970 0.557 ENSMUST00000020705.4
ENSMUST00000109985.1
Pes1

pescadillo homolog 1, containing BRCT domain (zebrafish)

chr11_+_97315716 0.520 ENSMUST00000019026.3
ENSMUST00000132168.1
Mrpl45

mitochondrial ribosomal protein L45

chr4_+_99929414 0.466 ENSMUST00000058351.9
Pgm2
phosphoglucomutase 2
chr4_+_123904832 0.463 ENSMUST00000030400.7
Mycbp
c-myc binding protein
chr12_+_72761211 0.447 ENSMUST00000021514.8
Ppm1a
protein phosphatase 1A, magnesium dependent, alpha isoform
chr2_+_91526756 0.439 ENSMUST00000111338.3
Ckap5
cytoskeleton associated protein 5
chr6_-_47813512 0.436 ENSMUST00000077290.7
Pdia4
protein disulfide isomerase associated 4
chr4_+_123904907 0.430 ENSMUST00000106202.3
Mycbp
c-myc binding protein
chr12_+_69372112 0.399 ENSMUST00000050063.7
Arf6
ADP-ribosylation factor 6
chr11_-_86807624 0.390 ENSMUST00000018569.7
Dhx40
DEAH (Asp-Glu-Ala-His) box polypeptide 40
chr3_-_95882232 0.356 ENSMUST00000161866.1
Gm129
predicted gene 129
chr4_+_117251951 0.329 ENSMUST00000062824.5
Tmem53
transmembrane protein 53
chr3_+_90052814 0.304 ENSMUST00000160640.1
ENSMUST00000029552.6
ENSMUST00000162114.1
ENSMUST00000068798.6
4933434E20Rik



RIKEN cDNA 4933434E20 gene



chr6_-_145076106 0.283 ENSMUST00000111742.1
ENSMUST00000048252.4
Bcat1

branched chain aminotransferase 1, cytosolic

chr2_+_144599897 0.274 ENSMUST00000028917.6
Dtd1
D-tyrosyl-tRNA deacylase 1
chr7_-_99626936 0.263 ENSMUST00000178124.1
Gm4980
predicted gene 4980
chr19_+_47178820 0.249 ENSMUST00000111808.3
Neurl1a
neuralized homolog 1A (Drosophila)
chr2_+_156065738 0.242 ENSMUST00000137966.1
Spag4
sperm associated antigen 4
chr4_+_117252010 0.232 ENSMUST00000125943.1
ENSMUST00000106434.1
Tmem53

transmembrane protein 53

chr15_+_38661904 0.195 ENSMUST00000022904.6
Atp6v1c1
ATPase, H+ transporting, lysosomal V1 subunit C1
chr17_-_25274299 0.133 ENSMUST00000172587.1
ENSMUST00000049911.9
ENSMUST00000173713.1
Ube2i


ubiquitin-conjugating enzyme E2I


chr1_+_193173469 0.122 ENSMUST00000161235.1
ENSMUST00000110831.2
ENSMUST00000178744.1
A130010J15Rik


RIKEN cDNA A130010J15 gene


chr4_-_123904826 0.092 ENSMUST00000181292.1
Gm26606
predicted gene, 26606
chr9_+_107563246 0.079 ENSMUST00000010198.3
Tusc2
tumor suppressor candidate 2
chr3_-_88177671 0.075 ENSMUST00000181837.1
1700113A16Rik
RIKEN cDNA 1700113A16 gene
chr7_-_131362687 0.056 ENSMUST00000059438.9
2310057M21Rik
RIKEN cDNA 2310057M21 gene
chr9_-_78443204 0.049 ENSMUST00000070742.7
ENSMUST00000034898.7
Mb21d1

Mab-21 domain containing 1

chr8_+_124722139 0.034 ENSMUST00000034463.3
Arv1
ARV1 homolog (yeast)
chr12_+_77239036 0.032 ENSMUST00000062804.7
Fut8
fucosyltransferase 8
chr6_-_57692007 0.029 ENSMUST00000053386.5
ENSMUST00000185014.1
Pyurf
PYURF
Pigy upstream reading frame
protein preY, mitochondrial precursor
chr11_-_120348091 0.015 ENSMUST00000106215.4
Actg1
actin, gamma, cytoplasmic 1
chr10_+_36974536 0.002 ENSMUST00000019911.7
Hdac2
histone deacetylase 2

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
10.1 90.5 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
5.1 15.2 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) musculoskeletal movement, spinal reflex action(GO:0050883) olfactory pit development(GO:0060166)
2.2 6.5 GO:0021759 globus pallidus development(GO:0021759)
1.9 5.8 GO:0010814 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
1.0 6.8 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.9 7.4 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.9 2.7 GO:0060167 regulation of adenosine receptor signaling pathway(GO:0060167) regulation of G-protein coupled receptor internalization(GO:1904020)
0.9 8.7 GO:0042095 interferon-gamma biosynthetic process(GO:0042095)
0.6 1.7 GO:0015772 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.5 4.3 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.4 2.0 GO:0010636 positive regulation of mitochondrial fusion(GO:0010636)
0.4 1.5 GO:0015744 succinate transport(GO:0015744)
0.4 1.1 GO:0009174 UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.2 4.7 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.2 5.5 GO:0045780 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.2 0.7 GO:0006344 maintenance of chromatin silencing(GO:0006344)
0.2 5.2 GO:0008340 determination of adult lifespan(GO:0008340)
0.2 1.5 GO:0038031 non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.2 1.8 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.1 0.4 GO:1903334 positive regulation of protein folding(GO:1903334)
0.1 1.1 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.1 1.1 GO:0033690 positive regulation of osteoblast proliferation(GO:0033690)
0.1 19.4 GO:0030326 embryonic limb morphogenesis(GO:0030326) embryonic appendage morphogenesis(GO:0035113)
0.1 3.5 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.1 1.3 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.1 5.8 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.1 12.6 GO:0030177 positive regulation of Wnt signaling pathway(GO:0030177)
0.1 0.4 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.1 0.6 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.1 0.6 GO:0007000 nucleolus organization(GO:0007000)
0.1 0.5 GO:0019388 galactose catabolic process(GO:0019388)
0.1 1.8 GO:0050850 positive regulation of calcium-mediated signaling(GO:0050850)
0.0 0.3 GO:0009098 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.0 2.1 GO:0014003 oligodendrocyte development(GO:0014003)
0.0 0.7 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.7 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 0.2 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0 0.4 GO:0034143 regulation of toll-like receptor 4 signaling pathway(GO:0034143)
0.0 1.7 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.0 0.3 GO:0006450 regulation of translational fidelity(GO:0006450)
0.0 0.1 GO:0070944 neutrophil mediated killing of bacterium(GO:0070944)
0.0 0.2 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0 0.2 GO:0015991 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991)
0.0 4.4 GO:1901657 glycosyl compound metabolic process(GO:1901657)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 5.8 GO:0033093 Weibel-Palade body(GO:0033093)
0.3 0.9 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.2 1.7 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.2 1.3 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 1.7 GO:0005652 nuclear lamina(GO:0005652)
0.1 15.2 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 1.8 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.1 0.6 GO:0070545 PeBoW complex(GO:0070545)
0.1 6.8 GO:0031225 anchored component of membrane(GO:0031225)
0.1 4.1 GO:0005657 replication fork(GO:0005657)
0.0 0.4 GO:0090543 Flemming body(GO:0090543)
0.0 4.0 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.7 GO:0071564 npBAF complex(GO:0071564)
0.0 0.4 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.4 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 4.8 GO:0005903 brush border(GO:0005903)
0.0 9.7 GO:0016607 nuclear speck(GO:0016607)
0.0 5.5 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 6.1 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.2 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 65.5 GO:0005829 cytosol(GO:0005829)
0.0 1.1 GO:0005581 collagen trimer(GO:0005581)
0.0 1.9 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 1.1 GO:0001726 ruffle(GO:0001726)
0.0 0.6 GO:0031519 PcG protein complex(GO:0031519)
0.0 0.0 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 2.4 GO:0005578 proteinaceous extracellular matrix(GO:0005578)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 90.5 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
1.4 4.3 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
1.2 4.8 GO:0008422 beta-glucosidase activity(GO:0008422)
0.9 6.8 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.7 2.7 GO:0031687 A2A adenosine receptor binding(GO:0031687)
0.6 4.7 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.6 1.7 GO:0008515 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.5 6.5 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.5 1.5 GO:0015140 malate transmembrane transporter activity(GO:0015140)
0.3 15.2 GO:0070888 E-box binding(GO:0070888)
0.2 7.4 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 1.3 GO:0071253 connexin binding(GO:0071253)
0.1 1.1 GO:0030274 LIM domain binding(GO:0030274)
0.1 1.1 GO:0031996 thioesterase binding(GO:0031996)
0.1 1.5 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 3.5 GO:0005109 frizzled binding(GO:0005109)
0.1 2.0 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1 11.5 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.1 0.4 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 1.7 GO:0034185 apolipoprotein binding(GO:0034185)
0.1 0.5 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.1 5.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.3 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.0 2.0 GO:0004521 endoribonuclease activity(GO:0004521)
0.0 0.4 GO:0015037 peptide disulfide oxidoreductase activity(GO:0015037)
0.0 0.9 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.4 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 1.1 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 1.5 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.7 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 1.6 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.3 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.0 0.2 GO:0043495 protein anchor(GO:0043495)
0.0 13.1 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0 0.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 4.7 GO:0005096 GTPase activator activity(GO:0005096)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 90.5 PID_IGF1_PATHWAY IGF1 pathway
0.5 4.3 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.3 12.0 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.3 8.7 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.2 15.2 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.1 2.6 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 0.9 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 6.1 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.5 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.0 4.7 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.4 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.9 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 0.4 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 0.5 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
4.3 90.5 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.4 4.3 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.3 4.7 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 5.5 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 1.7 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 2.0 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 1.1 REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.1 12.3 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 1.5 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 0.4 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 1.1 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.0 3.9 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.9 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.0 7.4 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 2.0 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.4 REACTOME_REGULATION_OF_AMPK_ACTIVITY_VIA_LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 0.5 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.3 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism