Motif ID: Myog_Tcf12

Z-value: 1.231

Transcription factors associated with Myog_Tcf12:

Gene SymbolEntrez IDGene Name
Myog ENSMUSG00000026459.4 Myog
Tcf12 ENSMUSG00000032228.10 Tcf12

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tcf12mm10_v2_chr9_-_72111651_72111712-0.278.2e-02Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Myog_Tcf12

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_154960915 10.842 ENSMUST00000049621.6
Hes5
hairy and enhancer of split 5 (Drosophila)
chr16_+_91269759 10.508 ENSMUST00000056882.5
Olig1
oligodendrocyte transcription factor 1
chr8_+_94152607 10.332 ENSMUST00000034211.8
Mt3
metallothionein 3
chr4_-_64046925 9.351 ENSMUST00000107377.3
Tnc
tenascin C
chr2_-_71546745 8.600 ENSMUST00000024159.6
Dlx2
distal-less homeobox 2
chr5_+_75075464 8.106 ENSMUST00000160104.1
ENSMUST00000040477.3
Gsx2

GS homeobox 2

chr16_-_22439719 8.096 ENSMUST00000079601.6
Etv5
ets variant gene 5
chr5_-_135251209 7.501 ENSMUST00000062572.2
Fzd9
frizzled homolog 9 (Drosophila)
chr12_-_119238794 7.476 ENSMUST00000026360.8
Itgb8
integrin beta 8
chr2_+_70562007 7.115 ENSMUST00000094934.4
Gad1
glutamate decarboxylase 1
chr7_+_19094594 6.723 ENSMUST00000049454.5
Six5
sine oculis-related homeobox 5
chr16_-_22439570 6.653 ENSMUST00000170393.1
Etv5
ets variant gene 5
chr2_-_122611238 6.546 ENSMUST00000028624.8
Gatm
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr18_+_57133065 6.365 ENSMUST00000075770.6
Megf10
multiple EGF-like-domains 10
chr12_+_108334341 6.344 ENSMUST00000021684.4
Cyp46a1
cytochrome P450, family 46, subfamily a, polypeptide 1
chr11_+_117809653 6.205 ENSMUST00000026649.7
ENSMUST00000177131.1
ENSMUST00000132298.1
Syngr2

Gm20708
synaptogyrin 2

predicted gene 20708
chr7_+_4119556 6.136 ENSMUST00000079415.5
Ttyh1
tweety homolog 1 (Drosophila)
chr7_+_4119525 6.118 ENSMUST00000119661.1
ENSMUST00000129423.1
Ttyh1

tweety homolog 1 (Drosophila)

chr11_+_115163333 5.997 ENSMUST00000021077.3
Slc9a3r1
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1
chr13_-_60177357 5.990 ENSMUST00000065086.4
Gas1
growth arrest specific 1
chr18_+_57142782 5.928 ENSMUST00000139892.1
Megf10
multiple EGF-like-domains 10
chr2_+_70562147 5.755 ENSMUST00000148210.1
Gad1
glutamate decarboxylase 1
chr8_+_12385769 5.616 ENSMUST00000080795.8
Gm5607
predicted gene 5607
chr11_+_112782182 5.259 ENSMUST00000000579.2
Sox9
SRY-box containing gene 9
chr15_+_78926720 5.133 ENSMUST00000089377.5
Lgals1
lectin, galactose binding, soluble 1
chr4_+_125490688 4.720 ENSMUST00000030676.7
Grik3
glutamate receptor, ionotropic, kainate 3
chr15_-_98004634 4.657 ENSMUST00000131560.1
ENSMUST00000088355.5
Col2a1

collagen, type II, alpha 1

chr7_+_45216671 4.554 ENSMUST00000134420.1
Tead2
TEA domain family member 2
chr15_-_98004695 4.488 ENSMUST00000023123.8
Col2a1
collagen, type II, alpha 1
chr14_-_25769033 4.153 ENSMUST00000069180.7
Zcchc24
zinc finger, CCHC domain containing 24
chr2_-_52335134 4.151 ENSMUST00000075301.3
Neb
nebulin
chr6_+_17307632 4.015 ENSMUST00000115453.1
Cav1
caveolin 1, caveolae protein
chr4_-_43523388 3.927 ENSMUST00000107913.3
ENSMUST00000030184.5
Tpm2

tropomyosin 2, beta

chr14_-_62292959 3.864 ENSMUST00000063169.8
Dleu7
deleted in lymphocytic leukemia, 7
chr3_-_98339921 3.841 ENSMUST00000065793.5
Phgdh
3-phosphoglycerate dehydrogenase
chr13_+_48261427 3.804 ENSMUST00000021810.1
Id4
inhibitor of DNA binding 4
chr9_+_30942541 3.692 ENSMUST00000068135.6
Adamts8
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 8
chr6_+_17307272 3.538 ENSMUST00000115454.1
Cav1
caveolin 1, caveolae protein
chr2_+_163225363 3.422 ENSMUST00000099110.3
ENSMUST00000165937.1
Tox2

TOX high mobility group box family member 2

chr18_+_60925612 3.420 ENSMUST00000102888.3
ENSMUST00000025519.4
Camk2a

calcium/calmodulin-dependent protein kinase II alpha

chr17_+_85621017 3.406 ENSMUST00000162695.2
Six3
sine oculis-related homeobox 3
chrX_+_100730178 3.378 ENSMUST00000113744.1
Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chr5_-_21701332 3.343 ENSMUST00000115217.1
ENSMUST00000060899.8
Napepld

N-acyl phosphatidylethanolamine phospholipase D

chr10_-_7212222 3.260 ENSMUST00000015346.5
Cnksr3
Cnksr family member 3
chr12_-_91779129 3.257 ENSMUST00000170077.1
Ston2
stonin 2
chr19_+_36409719 3.205 ENSMUST00000062389.5
Pcgf5
polycomb group ring finger 5
chr4_+_62583568 3.121 ENSMUST00000098031.3
Rgs3
regulator of G-protein signaling 3
chr7_+_130936172 3.102 ENSMUST00000006367.7
Htra1
HtrA serine peptidase 1
chr13_-_34345174 2.997 ENSMUST00000040336.5
Slc22a23
solute carrier family 22, member 23
chr15_+_25622525 2.968 ENSMUST00000110457.1
ENSMUST00000137601.1
Myo10

myosin X

chr9_-_39604124 2.965 ENSMUST00000042485.4
ENSMUST00000141370.1
AW551984

expressed sequence AW551984

chr14_-_20181773 2.965 ENSMUST00000024011.8
Kcnk5
potassium channel, subfamily K, member 5
chr7_-_25250720 2.819 ENSMUST00000116343.2
ENSMUST00000045847.8
Erf

Ets2 repressor factor

chr2_-_26092149 2.812 ENSMUST00000114159.2
Nacc2
nucleus accumbens associated 2, BEN and BTB (POZ) domain containing
chr2_+_25180737 2.802 ENSMUST00000104999.2
Nrarp
Notch-regulated ankyrin repeat protein
chr13_-_116309639 2.771 ENSMUST00000036060.6
Isl1
ISL1 transcription factor, LIM/homeodomain
chr15_-_71727815 2.745 ENSMUST00000022953.8
Fam135b
family with sequence similarity 135, member B
chr11_+_117809687 2.677 ENSMUST00000120928.1
ENSMUST00000175737.1
Syngr2

synaptogyrin 2

chr18_-_38601268 2.667 ENSMUST00000025295.6
Spry4
sprouty homolog 4 (Drosophila)
chr3_-_116253467 2.660 ENSMUST00000090473.5
Gpr88
G-protein coupled receptor 88
chr1_+_86045863 2.596 ENSMUST00000165824.1
2810459M11Rik
RIKEN cDNA 2810459M11 gene
chr5_+_147188678 2.581 ENSMUST00000065382.5
Gsx1
GS homeobox 1
chr9_+_35423582 2.516 ENSMUST00000154652.1
Cdon
cell adhesion molecule-related/down-regulated by oncogenes
chr19_-_24555819 2.514 ENSMUST00000112673.2
ENSMUST00000025800.8
Pip5k1b

phosphatidylinositol-4-phosphate 5-kinase, type 1 beta

chr9_+_85842852 2.471 ENSMUST00000098500.3
Tpbg
trophoblast glycoprotein
chr2_+_19909769 2.464 ENSMUST00000114610.1
Etl4
enhancer trap locus 4
chr1_-_64737735 2.453 ENSMUST00000063982.5
ENSMUST00000116133.2
Fzd5

frizzled homolog 5 (Drosophila)

chr2_+_91256144 2.450 ENSMUST00000154959.1
ENSMUST00000059566.4
Pacsin3

protein kinase C and casein kinase substrate in neurons 3

chr13_+_83504032 2.441 ENSMUST00000163888.1
ENSMUST00000005722.7
Mef2c

myocyte enhancer factor 2C

chr15_+_34238026 2.435 ENSMUST00000022867.3
Laptm4b
lysosomal-associated protein transmembrane 4B
chr11_-_101785252 2.415 ENSMUST00000164750.1
ENSMUST00000107176.1
ENSMUST00000017868.6
Etv4


ets variant gene 4 (E1A enhancer binding protein, E1AF)


chr16_+_65815508 2.415 ENSMUST00000168064.1
Vgll3
vestigial like 3 (Drosophila)
chrX_+_100729917 2.365 ENSMUST00000019503.7
Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chr12_+_81026800 2.355 ENSMUST00000110347.2
ENSMUST00000021564.4
ENSMUST00000129362.1
Smoc1


SPARC related modular calcium binding 1


chr15_-_74672560 2.307 ENSMUST00000023268.7
ENSMUST00000110009.3
Arc

activity regulated cytoskeletal-associated protein

chr1_-_120121030 2.279 ENSMUST00000027634.6
Dbi
diazepam binding inhibitor
chr12_-_40038025 2.278 ENSMUST00000101472.3
Arl4a
ADP-ribosylation factor-like 4A
chr11_-_67922136 2.268 ENSMUST00000021288.3
ENSMUST00000108677.1
Usp43

ubiquitin specific peptidase 43

chr1_-_120120937 2.260 ENSMUST00000151708.1
Dbi
diazepam binding inhibitor
chr9_-_107668967 2.246 ENSMUST00000177567.1
Slc38a3
solute carrier family 38, member 3
chrX_-_106485214 2.233 ENSMUST00000039447.7
Fndc3c1
fibronectin type III domain containing 3C1
chr7_+_44896125 2.229 ENSMUST00000166552.1
ENSMUST00000168207.1
Fuz

fuzzy homolog (Drosophila)

chr7_-_116308241 2.189 ENSMUST00000183057.1
ENSMUST00000182487.1
ENSMUST00000181998.1
Plekha7


pleckstrin homology domain containing, family A member 7


chr1_-_75506331 2.160 ENSMUST00000113567.2
ENSMUST00000113565.2
Obsl1

obscurin-like 1

chr2_+_14873656 2.138 ENSMUST00000114718.1
ENSMUST00000114719.1
Cacnb2

calcium channel, voltage-dependent, beta 2 subunit

chr4_-_43523595 2.136 ENSMUST00000107914.3
Tpm2
tropomyosin 2, beta
chr3_-_27153782 2.117 ENSMUST00000175857.1
ENSMUST00000177055.1
ENSMUST00000176535.1
Ect2


ect2 oncogene


chr6_-_148444336 2.096 ENSMUST00000060095.8
ENSMUST00000100772.3
Tmtc1

transmembrane and tetratricopeptide repeat containing 1

chr4_-_43523746 2.085 ENSMUST00000150592.1
Tpm2
tropomyosin 2, beta
chr9_-_48911067 2.070 ENSMUST00000003826.7
Htr3a
5-hydroxytryptamine (serotonin) receptor 3A
chr4_+_137862270 2.066 ENSMUST00000130407.1
Ece1
endothelin converting enzyme 1
chr4_+_15881255 2.062 ENSMUST00000029876.1
Calb1
calbindin 1
chr6_+_53573364 2.052 ENSMUST00000047450.7
Creb5
cAMP responsive element binding protein 5
chr7_+_126862431 2.036 ENSMUST00000132808.1
Hirip3
HIRA interacting protein 3
chrX_+_36328353 2.014 ENSMUST00000016383.3
Lonrf3
LON peptidase N-terminal domain and ring finger 3
chr3_-_27153844 2.011 ENSMUST00000176242.2
ENSMUST00000176780.1
Ect2

ect2 oncogene

chr6_-_127151044 2.010 ENSMUST00000000188.8
Ccnd2
cyclin D2
chr2_+_119047116 1.957 ENSMUST00000152380.1
ENSMUST00000099542.2
Casc5

cancer susceptibility candidate 5

chr13_-_51567084 1.957 ENSMUST00000021898.5
Shc3
src homology 2 domain-containing transforming protein C3
chr3_-_27153861 1.921 ENSMUST00000108300.1
ENSMUST00000108298.2
Ect2

ect2 oncogene

chr2_+_91255954 1.904 ENSMUST00000134699.1
Pacsin3
protein kinase C and casein kinase substrate in neurons 3
chr12_-_40037387 1.904 ENSMUST00000146905.1
Arl4a
ADP-ribosylation factor-like 4A
chr7_+_128523576 1.865 ENSMUST00000033136.7
Bag3
BCL2-associated athanogene 3
chr3_-_152266320 1.862 ENSMUST00000046045.8
Nexn
nexilin
chr7_-_116237767 1.857 ENSMUST00000182834.1
Plekha7
pleckstrin homology domain containing, family A member 7
chr19_-_57197556 1.847 ENSMUST00000099294.2
Ablim1
actin-binding LIM protein 1
chr3_+_137623672 1.829 ENSMUST00000053855.7
Ddit4l
DNA-damage-inducible transcript 4-like
chrX_-_48034842 1.820 ENSMUST00000039026.7
Apln
apelin
chr2_+_23321246 1.809 ENSMUST00000102945.1
Nxph2
neurexophilin 2
chr17_-_23684019 1.807 ENSMUST00000085989.5
Cldn9
claudin 9
chr15_-_66831625 1.797 ENSMUST00000164163.1
Sla
src-like adaptor
chr2_+_119047129 1.797 ENSMUST00000153300.1
ENSMUST00000028799.5
Casc5

cancer susceptibility candidate 5

chr9_-_96437434 1.777 ENSMUST00000070500.2
BC043934
cDNA sequence BC043934
chr9_-_48835932 1.759 ENSMUST00000093852.3
Zbtb16
zinc finger and BTB domain containing 16
chr7_-_62464505 1.751 ENSMUST00000094339.2
Peg12
paternally expressed 12
chr3_-_95904683 1.746 ENSMUST00000147962.1
ENSMUST00000036181.8
Car14

carbonic anhydrase 14

chr10_-_75860250 1.710 ENSMUST00000038169.6
Mif
macrophage migration inhibitory factor
chr17_+_56303321 1.675 ENSMUST00000001258.8
Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr1_+_187997821 1.675 ENSMUST00000027906.6
Esrrg
estrogen-related receptor gamma
chr7_-_30973464 1.668 ENSMUST00000001279.8
Lsr
lipolysis stimulated lipoprotein receptor
chr1_-_183147461 1.652 ENSMUST00000171366.1
Disp1
dispatched homolog 1 (Drosophila)
chr9_+_35421541 1.637 ENSMUST00000119129.2
Cdon
cell adhesion molecule-related/down-regulated by oncogenes
chr1_+_187997835 1.634 ENSMUST00000110938.1
Esrrg
estrogen-related receptor gamma
chr3_+_89229046 1.627 ENSMUST00000041142.3
Muc1
mucin 1, transmembrane
chr3_+_137624031 1.623 ENSMUST00000165845.1
Ddit4l
DNA-damage-inducible transcript 4-like
chr18_+_60963517 1.617 ENSMUST00000115295.2
ENSMUST00000039904.6
Camk2a

calcium/calmodulin-dependent protein kinase II alpha

chr19_-_57197496 1.585 ENSMUST00000111544.1
Ablim1
actin-binding LIM protein 1
chr13_-_56296551 1.571 ENSMUST00000021970.9
Cxcl14
chemokine (C-X-C motif) ligand 14
chr19_-_57197435 1.568 ENSMUST00000111550.1
Ablim1
actin-binding LIM protein 1
chr7_-_105482197 1.551 ENSMUST00000047040.2
Prkcdbp
protein kinase C, delta binding protein
chr10_+_123264076 1.539 ENSMUST00000050756.7
Fam19a2
family with sequence similarity 19, member A2
chr1_+_167598384 1.525 ENSMUST00000015987.3
Rxrg
retinoid X receptor gamma
chr1_+_167598450 1.504 ENSMUST00000111386.1
ENSMUST00000111384.1
Rxrg

retinoid X receptor gamma

chr19_+_42147373 1.498 ENSMUST00000061111.9
Marveld1
MARVEL (membrane-associating) domain containing 1
chr12_-_86079019 1.488 ENSMUST00000003687.6
Tgfb3
transforming growth factor, beta 3
chr19_-_57197377 1.475 ENSMUST00000111546.1
Ablim1
actin-binding LIM protein 1
chr10_+_11609256 1.471 ENSMUST00000052902.7
Gm9797
predicted pseudogene 9797
chr13_+_19623163 1.463 ENSMUST00000002883.5
Sfrp4
secreted frizzled-related protein 4
chr19_+_6105774 1.456 ENSMUST00000044451.3
Naaladl1
N-acetylated alpha-linked acidic dipeptidase-like 1
chr17_+_56303396 1.445 ENSMUST00000113038.1
Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr6_+_17307040 1.435 ENSMUST00000123439.1
Cav1
caveolin 1, caveolae protein
chr7_-_142578093 1.424 ENSMUST00000149974.1
ENSMUST00000152754.1
H19

H19 fetal liver mRNA

chr5_-_98566762 1.423 ENSMUST00000086912.4
1700010H22Rik
RIKEN cDNA 1700010H22 gene
chr8_-_71381907 1.422 ENSMUST00000002466.8
Nr2f6
nuclear receptor subfamily 2, group F, member 6
chrX_-_57338598 1.412 ENSMUST00000033468.4
ENSMUST00000114736.1
Arhgef6

Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6

chr15_-_66812593 1.411 ENSMUST00000100572.3
Sla
src-like adaptor
chr18_+_60925644 1.403 ENSMUST00000115297.1
Camk2a
calcium/calmodulin-dependent protein kinase II alpha
chr13_-_81570640 1.392 ENSMUST00000109565.2
Gpr98
G protein-coupled receptor 98
chr17_-_89910449 1.392 ENSMUST00000086423.4
Gm10184
predicted pseudogene 10184
chr2_-_75704535 1.391 ENSMUST00000102672.4
Nfe2l2
nuclear factor, erythroid derived 2, like 2
chr2_-_93334467 1.388 ENSMUST00000111265.2
Tspan18
tetraspanin 18
chr1_+_157412352 1.374 ENSMUST00000061537.5
2810025M15Rik
RIKEN cDNA 2810025M15 gene
chr7_-_30973399 1.359 ENSMUST00000098553.4
ENSMUST00000147431.1
Lsr

lipolysis stimulated lipoprotein receptor

chr10_+_67979592 1.359 ENSMUST00000105437.1
Rtkn2
rhotekin 2
chr9_-_37433138 1.355 ENSMUST00000115038.1
Robo3
roundabout homolog 3 (Drosophila)
chr10_+_67979569 1.337 ENSMUST00000118160.1
Rtkn2
rhotekin 2
chr9_+_53884082 1.336 ENSMUST00000077997.2
Gm16380
predicted pseudogene 16380
chr3_-_141982224 1.332 ENSMUST00000029948.8
Bmpr1b
bone morphogenetic protein receptor, type 1B
chr7_-_142578139 1.307 ENSMUST00000136359.1
H19
H19 fetal liver mRNA
chr7_+_44896077 1.306 ENSMUST00000071207.7
ENSMUST00000166849.1
ENSMUST00000168712.1
ENSMUST00000168389.1
Fuz



fuzzy homolog (Drosophila)



chr1_-_126738167 1.306 ENSMUST00000160693.1
Nckap5
NCK-associated protein 5
chr6_-_72235559 1.296 ENSMUST00000042646.7
Atoh8
atonal homolog 8 (Drosophila)
chr3_-_73708399 1.286 ENSMUST00000029367.5
Bche
butyrylcholinesterase
chr1_-_75505641 1.286 ENSMUST00000155084.1
Obsl1
obscurin-like 1
chr15_-_81729864 1.282 ENSMUST00000171115.1
ENSMUST00000170134.1
ENSMUST00000052374.5
Rangap1


RAN GTPase activating protein 1


chr7_-_79617642 1.275 ENSMUST00000032766.4
Rhcg
Rhesus blood group-associated C glycoprotein
chr16_-_52452654 1.268 ENSMUST00000168071.1
Alcam
activated leukocyte cell adhesion molecule
chr16_-_67620880 1.265 ENSMUST00000114292.1
ENSMUST00000120898.1
Cadm2

cell adhesion molecule 2

chr7_-_30973367 1.262 ENSMUST00000108116.3
Lsr
lipolysis stimulated lipoprotein receptor
chrX_+_143518671 1.244 ENSMUST00000134402.1
Pak3
p21 protein (Cdc42/Rac)-activated kinase 3
chr4_+_137862237 1.243 ENSMUST00000102518.3
Ece1
endothelin converting enzyme 1
chr14_-_65425453 1.234 ENSMUST00000059339.5
Pnoc
prepronociceptin
chr12_-_45074457 1.233 ENSMUST00000053768.6
Stxbp6
syntaxin binding protein 6 (amisyn)
chr6_-_53820764 1.230 ENSMUST00000127748.2
Tril
TLR4 interactor with leucine-rich repeats
chr2_-_137116624 1.223 ENSMUST00000028735.7
Jag1
jagged 1
chr2_+_91259822 1.222 ENSMUST00000138470.1
Pacsin3
protein kinase C and casein kinase substrate in neurons 3
chr3_-_25212720 1.218 ENSMUST00000091289.3
Gm10259
predicted pseudogene 10259
chr3_-_68870266 1.214 ENSMUST00000166328.1
Gm17641
predicted gene, 17641
chr4_+_152008803 1.213 ENSMUST00000097773.3
Klhl21
kelch-like 21
chr11_+_71749914 1.207 ENSMUST00000150531.1
Wscd1
WSC domain containing 1
chr6_+_29694204 1.178 ENSMUST00000046750.7
ENSMUST00000115250.3
Tspan33

tetraspanin 33

chrX_-_36989656 1.176 ENSMUST00000060474.7
ENSMUST00000053456.4
ENSMUST00000115239.3
Sept6


septin 6


chr10_+_26772477 1.175 ENSMUST00000039557.7
Arhgap18
Rho GTPase activating protein 18
chr17_+_79051906 1.169 ENSMUST00000040789.4
Qpct
glutaminyl-peptide cyclotransferase (glutaminyl cyclase)
chr9_+_34486125 1.168 ENSMUST00000115148.2
ENSMUST00000183580.1
Kirrel3
RP24-225I21.1
kin of IRRE like 3 (Drosophila)
RP24-225I21.1
chr8_+_75109528 1.162 ENSMUST00000164309.1
Mcm5
minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
chr6_-_21851914 1.140 ENSMUST00000134635.1
ENSMUST00000123116.1
ENSMUST00000120965.1
Tspan12


tetraspanin 12


chr2_+_131186942 1.115 ENSMUST00000028804.8
ENSMUST00000079857.8
Cdc25b

cell division cycle 25B

chrX_-_106485367 1.112 ENSMUST00000140707.1
Fndc3c1
fibronectin type III domain containing 3C1
chr2_-_140671440 1.101 ENSMUST00000099301.1
Flrt3
fibronectin leucine rich transmembrane protein 3
chr2_-_170406501 1.096 ENSMUST00000154650.1
Bcas1
breast carcinoma amplified sequence 1
chr17_+_47505211 1.095 ENSMUST00000182935.1
ENSMUST00000182506.1
Ccnd3

cyclin D3

chr14_-_68124836 1.095 ENSMUST00000111089.1
ENSMUST00000022638.5
Nefm

neurofilament, medium polypeptide

chr15_-_55090422 1.091 ENSMUST00000110231.1
ENSMUST00000023059.6
Dscc1

defective in sister chromatid cohesion 1 homolog (S. cerevisiae)

chr17_+_47505043 1.083 ENSMUST00000182129.1
ENSMUST00000171031.1
Ccnd3

cyclin D3

chr11_-_79146407 1.071 ENSMUST00000018478.4
ENSMUST00000108264.1
Ksr1

kinase suppressor of ras 1

chr5_-_115436508 1.069 ENSMUST00000078701.3
4930430O22Rik
RIKEN cDNA 4930430O22 gene
chr1_-_119053339 1.067 ENSMUST00000161301.1
ENSMUST00000161451.1
ENSMUST00000162607.1
Gli2


GLI-Kruppel family member GLI2


chr17_+_47505149 1.065 ENSMUST00000183177.1
ENSMUST00000182848.1
Ccnd3

cyclin D3

chr18_-_41951187 1.063 ENSMUST00000070949.4
Prelid2
PRELI domain containing 2

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.4 10.3 GO:0097212 lysosomal membrane organization(GO:0097212)
3.3 16.5 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
2.9 8.6 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
2.7 10.8 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
2.5 7.5 GO:1990523 bone regeneration(GO:1990523)
2.3 9.4 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
2.2 6.5 GO:0006601 creatine biosynthetic process(GO:0006601)
2.1 16.4 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
2.0 6.0 GO:0042939 glutathione transport(GO:0034635) tripeptide transport(GO:0042939)
1.9 16.7 GO:0009448 gamma-aminobutyric acid metabolic process(GO:0009448)
1.8 9.0 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
1.8 5.3 GO:0035622 intrahepatic bile duct development(GO:0035622)
1.4 4.3 GO:1904274 tricellular tight junction assembly(GO:1904274)
1.3 1.3 GO:0014016 neuroblast differentiation(GO:0014016)
1.2 3.5 GO:2000314 negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314)
1.1 3.4 GO:0097402 neuroblast migration(GO:0097402)
1.1 3.3 GO:0010814 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
1.1 6.4 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
1.0 3.8 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
0.9 2.8 GO:0032650 regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730) cardiac cell fate determination(GO:0060913)
0.9 4.5 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
0.9 2.7 GO:0003345 proepicardium cell migration involved in pericardium morphogenesis(GO:0003345)
0.9 5.1 GO:0002317 plasma cell differentiation(GO:0002317) positive regulation of viral entry into host cell(GO:0046598)
0.8 10.0 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.8 2.4 GO:0007521 muscle cell fate determination(GO:0007521) positive regulation of macrophage apoptotic process(GO:2000111)
0.8 10.5 GO:0021527 spinal cord association neuron differentiation(GO:0021527)
0.7 0.7 GO:0060423 foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492)
0.7 1.5 GO:1902174 positive regulation of keratinocyte apoptotic process(GO:1902174)
0.7 2.1 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.7 6.4 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.7 3.4 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.7 4.0 GO:0045218 zonula adherens maintenance(GO:0045218)
0.7 3.3 GO:1903998 regulation of eating behavior(GO:1903998)
0.7 2.7 GO:0061743 motor learning(GO:0061743)
0.6 6.4 GO:0038166 angiotensin-activated signaling pathway(GO:0038166)
0.6 0.6 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
0.6 1.8 GO:1904020 regulation of G-protein coupled receptor internalization(GO:1904020)
0.6 3.0 GO:0060923 cardiac muscle cell fate commitment(GO:0060923)
0.6 2.3 GO:0002035 brain renin-angiotensin system(GO:0002035)
0.6 2.8 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.6 6.7 GO:0014842 skeletal muscle satellite cell proliferation(GO:0014841) regulation of skeletal muscle satellite cell proliferation(GO:0014842)
0.5 5.5 GO:0090527 actin filament reorganization(GO:0090527)
0.5 1.1 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.5 5.8 GO:0042473 outer ear morphogenesis(GO:0042473)
0.5 1.5 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.5 1.0 GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.5 1.9 GO:0060032 notochord regression(GO:0060032)
0.5 2.4 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.5 1.4 GO:2000501 natural killer cell chemotaxis(GO:0035747) regulation of natural killer cell chemotaxis(GO:2000501)
0.5 2.3 GO:0072235 distal convoluted tubule development(GO:0072025) metanephric distal convoluted tubule development(GO:0072221) metanephric distal tubule development(GO:0072235)
0.5 1.4 GO:0061642 chemoattraction of axon(GO:0061642)
0.4 2.2 GO:0015817 histidine transport(GO:0015817) cellular response to potassium ion starvation(GO:0051365)
0.4 7.1 GO:0001573 ganglioside metabolic process(GO:0001573)
0.4 1.8 GO:0016340 calcium-dependent cell-matrix adhesion(GO:0016340)
0.4 4.7 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.4 1.3 GO:0070634 transepithelial ammonium transport(GO:0070634)
0.4 2.8 GO:0014807 regulation of somitogenesis(GO:0014807)
0.4 1.2 GO:0018199 peptidyl-glutamine modification(GO:0018199)
0.4 1.5 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.4 1.8 GO:0032423 regulation of mismatch repair(GO:0032423)
0.3 1.4 GO:1902037 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091) negative regulation of hematopoietic stem cell differentiation(GO:1902037)
0.3 2.0 GO:2000969 positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000969)
0.3 6.0 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.3 1.0 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.3 1.3 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.3 3.1 GO:0090308 regulation of methylation-dependent chromatin silencing(GO:0090308)
0.3 1.9 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.3 1.2 GO:0061073 ciliary body morphogenesis(GO:0061073)
0.3 0.9 GO:1900108 negative regulation of nodal signaling pathway(GO:1900108)
0.3 12.6 GO:1902476 chloride transmembrane transport(GO:1902476)
0.3 0.9 GO:0098912 membrane depolarization during atrial cardiac muscle cell action potential(GO:0098912)
0.3 0.3 GO:0021593 rhombomere morphogenesis(GO:0021593)
0.3 1.4 GO:0002121 inter-male aggressive behavior(GO:0002121)
0.3 4.6 GO:0030903 notochord development(GO:0030903)
0.3 1.0 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.3 1.0 GO:0001826 inner cell mass cell differentiation(GO:0001826)
0.3 4.3 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.3 0.8 GO:0019405 alditol catabolic process(GO:0019405) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.2 1.7 GO:0015670 carbon dioxide transport(GO:0015670)
0.2 2.7 GO:2000653 regulation of genetic imprinting(GO:2000653)
0.2 0.2 GO:0002034 angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001998) regulation of blood vessel size by renin-angiotensin(GO:0002034) renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure(GO:0003072)
0.2 0.9 GO:0014722 regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
0.2 2.8 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.2 1.9 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.2 0.7 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
0.2 4.5 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.2 0.7 GO:1904393 regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904393)
0.2 0.7 GO:0014832 urinary bladder smooth muscle contraction(GO:0014832)
0.2 0.9 GO:2000832 androgen secretion(GO:0035935) testosterone secretion(GO:0035936) positive regulation of apoptotic DNA fragmentation(GO:1902512) negative regulation of steroid hormone secretion(GO:2000832) regulation of androgen secretion(GO:2000834) regulation of testosterone secretion(GO:2000843)
0.2 0.6 GO:2000642 negative regulation of early endosome to late endosome transport(GO:2000642)
0.2 0.6 GO:0045819 plasmacytoid dendritic cell activation(GO:0002270) positive regulation of glycogen catabolic process(GO:0045819)
0.2 0.6 GO:0015938 coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034)
0.2 0.6 GO:0030202 heparin metabolic process(GO:0030202)
0.2 0.6 GO:0006285 base-excision repair, AP site formation(GO:0006285)
0.2 0.6 GO:0035470 positive regulation of vascular wound healing(GO:0035470)
0.2 0.4 GO:0031660 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662)
0.2 0.6 GO:0015772 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.2 1.7 GO:0050965 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.2 0.9 GO:0034421 post-translational protein acetylation(GO:0034421)
0.2 1.3 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.2 0.5 GO:1904690 regulation of cap-independent translational initiation(GO:1903677) positive regulation of cap-independent translational initiation(GO:1903679) regulation of cytoplasmic translational initiation(GO:1904688) positive regulation of cytoplasmic translational initiation(GO:1904690)
0.2 0.7 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.2 0.3 GO:1901420 negative regulation of response to alcohol(GO:1901420)
0.2 1.1 GO:0007144 female meiosis I(GO:0007144)
0.2 0.6 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.1 0.9 GO:0033632 regulation of cell-cell adhesion mediated by integrin(GO:0033632)
0.1 0.6 GO:1904529 B cell proliferation involved in immune response(GO:0002322) regulation of actin filament binding(GO:1904529) regulation of actin binding(GO:1904616)
0.1 1.3 GO:0046826 negative regulation of protein export from nucleus(GO:0046826)
0.1 1.8 GO:0071481 cellular response to X-ray(GO:0071481)
0.1 0.4 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.1 0.8 GO:2001170 negative regulation of ATP biosynthetic process(GO:2001170)
0.1 3.4 GO:2000651 positive regulation of sodium ion transmembrane transporter activity(GO:2000651)
0.1 1.9 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.1 0.4 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.1 0.5 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 1.3 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 0.6 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.1 0.5 GO:0033580 protein glycosylation at cell surface(GO:0033575) protein galactosylation at cell surface(GO:0033580) protein galactosylation(GO:0042125)
0.1 0.7 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.1 0.5 GO:1902309 negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.1 8.5 GO:0048663 neuron fate commitment(GO:0048663)
0.1 0.4 GO:0014819 regulation of skeletal muscle contraction(GO:0014819)
0.1 6.3 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.1 0.2 GO:0060025 regulation of synaptic activity(GO:0060025)
0.1 0.9 GO:0070296 sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.1 0.6 GO:0097491 trigeminal nerve morphogenesis(GO:0021636) trigeminal nerve structural organization(GO:0021637) trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486) sympathetic neuron projection extension(GO:0097490) sympathetic neuron projection guidance(GO:0097491) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287)
0.1 1.0 GO:0007567 parturition(GO:0007567)
0.1 0.3 GO:0045113 regulation of integrin biosynthetic process(GO:0045113)
0.1 0.9 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.1 1.0 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.1 0.9 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.1 0.3 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.1 3.7 GO:0045214 sarcomere organization(GO:0045214)
0.1 1.6 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.1 1.9 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.1 1.0 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.1 0.2 GO:0045578 negative regulation of B cell differentiation(GO:0045578)
0.1 0.3 GO:0009174 UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.1 1.0 GO:0006020 inositol metabolic process(GO:0006020)
0.1 0.4 GO:1903760 regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903760) regulation of potassium ion export across plasma membrane(GO:1903764) regulation of membrane repolarization during ventricular cardiac muscle cell action potential(GO:1905024)
0.1 1.0 GO:0060539 diaphragm development(GO:0060539)
0.1 1.0 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.1 1.1 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.1 0.7 GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway(GO:0010804)
0.1 0.9 GO:0042095 interferon-gamma biosynthetic process(GO:0042095)
0.1 0.6 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.1 1.7 GO:0045780 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.1 2.9 GO:0050873 brown fat cell differentiation(GO:0050873)
0.1 0.4 GO:0061436 establishment of skin barrier(GO:0061436)
0.1 0.8 GO:0007398 ectoderm development(GO:0007398)
0.1 0.7 GO:0099550 trans-synaptic signalling, modulating synaptic transmission(GO:0099550)
0.1 0.8 GO:0030539 male genitalia development(GO:0030539)
0.1 1.3 GO:0001553 luteinization(GO:0001553)
0.1 1.3 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.1 0.4 GO:0045059 positive thymic T cell selection(GO:0045059)
0.1 1.8 GO:0000578 embryonic axis specification(GO:0000578)
0.1 0.1 GO:0002331 pre-B cell allelic exclusion(GO:0002331)
0.1 0.9 GO:0032414 positive regulation of ion transmembrane transporter activity(GO:0032414)
0.1 2.2 GO:0010842 retina layer formation(GO:0010842)
0.1 5.5 GO:0030032 lamellipodium assembly(GO:0030032)
0.1 0.4 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.1 0.4 GO:0050957 equilibrioception(GO:0050957)
0.1 0.2 GO:0015886 heme transport(GO:0015886)
0.1 0.4 GO:0045839 negative regulation of mitotic nuclear division(GO:0045839)
0.1 0.3 GO:0070314 G1 to G0 transition(GO:0070314)
0.1 0.3 GO:0010726 positive regulation of hydrogen peroxide metabolic process(GO:0010726)
0.1 0.7 GO:0038092 nodal signaling pathway(GO:0038092)
0.1 0.4 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.1 0.3 GO:0010288 response to lead ion(GO:0010288)
0.1 0.5 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.1 0.2 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.1 0.7 GO:0048875 chemical homeostasis within a tissue(GO:0048875)
0.1 0.3 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.1 0.2 GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615)
0.1 0.5 GO:0016446 somatic hypermutation of immunoglobulin genes(GO:0016446)
0.1 1.1 GO:0034142 toll-like receptor 4 signaling pathway(GO:0034142)
0.1 0.4 GO:0010820 positive regulation of T cell chemotaxis(GO:0010820)
0.1 0.4 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.1 0.4 GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway(GO:0070423) nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070431)
0.1 0.1 GO:0002191 cap-dependent translational initiation(GO:0002191)
0.1 0.2 GO:1903490 regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490)
0.1 0.2 GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
0.1 0.6 GO:0021924 cell proliferation in external granule layer(GO:0021924) cerebellar granule cell precursor proliferation(GO:0021930)
0.1 0.3 GO:1902732 positive regulation of chondrocyte proliferation(GO:1902732)
0.1 0.2 GO:0002143 tRNA wobble position uridine thiolation(GO:0002143)
0.1 0.6 GO:0048642 negative regulation of skeletal muscle tissue development(GO:0048642)
0.1 0.4 GO:1902036 regulation of hematopoietic stem cell differentiation(GO:1902036)
0.1 0.2 GO:0019323 pentose catabolic process(GO:0019323)
0.1 0.2 GO:1903795 regulation of inorganic anion transmembrane transport(GO:1903795)
0.0 0.1 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.0 0.3 GO:1990481 mRNA pseudouridine synthesis(GO:1990481)
0.0 0.1 GO:0035574 histone H4-K20 demethylation(GO:0035574)
0.0 0.2 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.0 0.2 GO:1900220 semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220)
0.0 0.5 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 1.4 GO:0006270 DNA replication initiation(GO:0006270)
0.0 1.0 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.0 0.2 GO:0032439 endosome localization(GO:0032439)
0.0 0.3 GO:0006071 glycerol metabolic process(GO:0006071)
0.0 0.4 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.0 0.6 GO:1904816 positive regulation of protein localization to chromosome, telomeric region(GO:1904816)
0.0 0.1 GO:0001193 maintenance of transcriptional fidelity during DNA-templated transcription elongation(GO:0001192) maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter(GO:0001193)
0.0 0.4 GO:0006560 proline metabolic process(GO:0006560)
0.0 0.1 GO:0048548 regulation of pinocytosis(GO:0048548)
0.0 0.7 GO:0021522 spinal cord motor neuron differentiation(GO:0021522)
0.0 0.5 GO:0032785 negative regulation of DNA-templated transcription, elongation(GO:0032785)
0.0 0.2 GO:0046391 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.0 1.2 GO:0034629 cellular protein complex localization(GO:0034629)
0.0 0.5 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.0 0.2 GO:0048853 forebrain morphogenesis(GO:0048853)
0.0 2.5 GO:0006661 phosphatidylinositol biosynthetic process(GO:0006661)
0.0 0.3 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.2 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 0.2 GO:0009068 aspartate family amino acid catabolic process(GO:0009068)
0.0 0.3 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.0 0.4 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.0 0.3 GO:0060736 prostate gland growth(GO:0060736)
0.0 2.1 GO:0043407 negative regulation of MAP kinase activity(GO:0043407)
0.0 0.2 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.0 0.7 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.0 0.7 GO:0071711 basement membrane organization(GO:0071711)
0.0 0.5 GO:0048199 vesicle targeting, to, from or within Golgi(GO:0048199)
0.0 0.7 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.0 0.2 GO:0035720 intraciliary anterograde transport(GO:0035720)
0.0 0.1 GO:0010991 regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.3 GO:0045176 apical protein localization(GO:0045176)
0.0 0.4 GO:0090205 positive regulation of cholesterol biosynthetic process(GO:0045542) positive regulation of cholesterol metabolic process(GO:0090205)
0.0 0.4 GO:1901223 negative regulation of NIK/NF-kappaB signaling(GO:1901223)
0.0 0.5 GO:0030835 negative regulation of actin filament depolymerization(GO:0030835)
0.0 0.4 GO:0035036 binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036)
0.0 0.5 GO:0006415 translational termination(GO:0006415)
0.0 0.3 GO:0042182 ketone catabolic process(GO:0042182)
0.0 0.9 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 0.2 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.0 0.0 GO:0031268 pseudopodium organization(GO:0031268)
0.0 0.3 GO:0002227 innate immune response in mucosa(GO:0002227)
0.0 0.3 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.2 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.5 GO:0051764 actin crosslink formation(GO:0051764)
0.0 0.1 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.0 0.1 GO:0009446 putrescine biosynthetic process(GO:0009446)
0.0 0.2 GO:0010801 negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
0.0 0.1 GO:0061029 eyelid development in camera-type eye(GO:0061029)
0.0 0.0 GO:1902162 regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162)
0.0 0.1 GO:0045199 maintenance of epithelial cell apical/basal polarity(GO:0045199)
0.0 0.1 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.0 0.1 GO:0061002 negative regulation of dendritic spine morphogenesis(GO:0061002)
0.0 0.2 GO:0006105 succinate metabolic process(GO:0006105)
0.0 0.1 GO:0036006 response to macrophage colony-stimulating factor(GO:0036005) cellular response to macrophage colony-stimulating factor stimulus(GO:0036006)
0.0 0.4 GO:0010569 regulation of double-strand break repair via homologous recombination(GO:0010569)
0.0 0.2 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0 0.5 GO:0008340 determination of adult lifespan(GO:0008340)
0.0 0.2 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.1 GO:0006177 GMP biosynthetic process(GO:0006177)
0.0 0.1 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.0 0.3 GO:0007202 activation of phospholipase C activity(GO:0007202)
0.0 0.1 GO:0032460 negative regulation of protein oligomerization(GO:0032460) negative regulation of protein homooligomerization(GO:0032463)
0.0 0.1 GO:0072718 response to cisplatin(GO:0072718)
0.0 0.5 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 2.6 GO:0008360 regulation of cell shape(GO:0008360)
0.0 0.1 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 0.1 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.0 0.4 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)
0.0 0.5 GO:0034394 protein localization to cell surface(GO:0034394)
0.0 0.2 GO:0042104 positive regulation of activated T cell proliferation(GO:0042104)
0.0 1.1 GO:0006342 chromatin silencing(GO:0006342)
0.0 0.2 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 0.1 GO:0090070 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
0.0 0.2 GO:0019985 translesion synthesis(GO:0019985)
0.0 0.9 GO:0048706 embryonic skeletal system development(GO:0048706)
0.0 0.2 GO:0009649 entrainment of circadian clock(GO:0009649)
0.0 0.4 GO:0007492 endoderm development(GO:0007492)
0.0 0.3 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 0.3 GO:0007131 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.0 0.5 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 1.2 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.0 0.1 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.0 0.0 GO:0035523 protein K29-linked deubiquitination(GO:0035523) protein K6-linked deubiquitination(GO:0044313)
0.0 0.4 GO:0015914 phospholipid transport(GO:0015914)
0.0 0.0 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.0 0.6 GO:0033045 regulation of sister chromatid segregation(GO:0033045)
0.0 0.2 GO:0007340 acrosome reaction(GO:0007340)
0.0 0.3 GO:0007080 mitotic metaphase plate congression(GO:0007080)
0.0 0.1 GO:0032049 cardiolipin biosynthetic process(GO:0032049)
0.0 0.1 GO:0097119 postsynaptic density protein 95 clustering(GO:0097119)
0.0 0.4 GO:0071277 cellular response to calcium ion(GO:0071277)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
4.1 12.3 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
2.1 6.4 GO:0099573 glutamatergic postsynaptic density(GO:0099573)
1.5 4.6 GO:0071149 TEAD-2-YAP complex(GO:0071149)
1.2 6.0 GO:0097149 centralspindlin complex(GO:0097149)
0.7 9.0 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.7 8.1 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.7 3.3 GO:0033093 Weibel-Palade body(GO:0033093)
0.7 3.9 GO:0061689 tricellular tight junction(GO:0061689)
0.6 8.1 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.6 3.4 GO:0005859 muscle myosin complex(GO:0005859)
0.5 8.6 GO:0005614 interstitial matrix(GO:0005614)
0.5 10.7 GO:0001891 phagocytic cup(GO:0001891)
0.5 5.8 GO:0032426 stereocilium tip(GO:0032426)
0.5 1.9 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.4 7.9 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.4 0.9 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.4 1.3 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.4 1.2 GO:0005940 septin ring(GO:0005940)
0.4 4.0 GO:0005915 zonula adherens(GO:0005915)
0.3 1.8 GO:0016011 dystroglycan complex(GO:0016011)
0.3 10.6 GO:0060077 inhibitory synapse(GO:0060077)
0.3 2.5 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.3 0.8 GO:1990423 RZZ complex(GO:1990423)
0.3 4.2 GO:0005865 striated muscle thin filament(GO:0005865) myofilament(GO:0036379)
0.3 0.8 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.2 4.8 GO:0031527 filopodium membrane(GO:0031527)
0.2 1.2 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.2 1.5 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.2 1.2 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.2 1.0 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.2 0.8 GO:0097651 phosphatidylinositol 3-kinase complex, class I(GO:0097651)
0.2 1.2 GO:0005827 polar microtubule(GO:0005827)
0.2 5.0 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.2 0.8 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.1 1.9 GO:0097542 ciliary tip(GO:0097542)
0.1 2.2 GO:0042555 MCM complex(GO:0042555)
0.1 1.7 GO:0005641 nuclear envelope lumen(GO:0005641)
0.1 1.4 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 0.8 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.1 0.4 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.1 0.7 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.1 1.2 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.1 0.9 GO:0016600 flotillin complex(GO:0016600)
0.1 0.6 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.1 1.1 GO:0005883 neurofilament(GO:0005883)
0.1 3.1 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 2.8 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 7.6 GO:0031970 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.1 0.5 GO:0036396 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.1 7.4 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 0.5 GO:0001533 cornified envelope(GO:0001533)
0.1 5.0 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 2.8 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 1.6 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 1.6 GO:0000145 exocyst(GO:0000145)
0.1 0.3 GO:0005606 laminin-1 complex(GO:0005606)
0.1 0.9 GO:0042101 T cell receptor complex(GO:0042101)
0.1 7.1 GO:0005884 actin filament(GO:0005884)
0.1 0.2 GO:0030056 hemidesmosome(GO:0030056)
0.1 0.8 GO:0016589 NURF complex(GO:0016589)
0.1 0.3 GO:0005840 ribosome(GO:0005840)
0.1 4.7 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 3.5 GO:0016459 myosin complex(GO:0016459)
0.1 2.4 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 0.6 GO:0016442 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.1 0.4 GO:0005638 lamin filament(GO:0005638)
0.1 0.2 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.1 1.4 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 3.6 GO:0031519 PcG protein complex(GO:0031519)
0.1 2.8 GO:0000791 euchromatin(GO:0000791)
0.1 7.2 GO:0008021 synaptic vesicle(GO:0008021)
0.1 0.3 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 0.4 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 0.0 GO:0016342 catenin complex(GO:0016342)
0.0 0.7 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.3 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.3 GO:0005677 chromatin silencing complex(GO:0005677)
0.0 0.5 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.3 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 0.2 GO:0045283 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0 0.7 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 2.8 GO:0005844 polysome(GO:0005844)
0.0 0.4 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.7 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.3 GO:0042587 glycogen granule(GO:0042587)
0.0 0.5 GO:0002102 podosome(GO:0002102)
0.0 0.4 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.4 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 0.3 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.2 GO:0031011 Ino80 complex(GO:0031011) cytosolic proteasome complex(GO:0031597)
0.0 0.8 GO:0030904 retromer complex(GO:0030904)
0.0 0.2 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.3 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 1.0 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.2 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.0 1.1 GO:0005871 kinesin complex(GO:0005871)
0.0 0.2 GO:0034709 methylosome(GO:0034709)
0.0 0.1 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.3 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.8 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.2 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 7.0 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.4 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.0 8.8 GO:0009986 cell surface(GO:0009986)
0.0 4.3 GO:0016607 nuclear speck(GO:0016607)
0.0 0.4 GO:0030018 Z disc(GO:0030018)
0.0 1.4 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 0.8 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.3 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.3 GO:0043034 costamere(GO:0043034)
0.0 0.1 GO:0031083 BLOC-1 complex(GO:0031083)
0.0 0.1 GO:0001940 male pronucleus(GO:0001940)
0.0 0.0 GO:0071556 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553) lumenal side of membrane(GO:0098576)
0.0 1.0 GO:0000922 spindle pole(GO:0000922)
0.0 0.2 GO:0032039 integrator complex(GO:0032039)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 12.3 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
1.8 12.9 GO:0004351 glutamate decarboxylase activity(GO:0004351)
1.8 9.1 GO:0042289 MHC class II protein binding(GO:0042289)
1.8 9.0 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
1.8 12.3 GO:0001849 complement component C1q binding(GO:0001849)
1.6 9.4 GO:0045545 syndecan binding(GO:0045545)
1.5 4.5 GO:0030156 benzodiazepine receptor binding(GO:0030156)
1.1 7.5 GO:1990430 extracellular matrix protein binding(GO:1990430)
1.0 4.8 GO:0005534 galactose binding(GO:0005534)
0.9 4.7 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.8 3.1 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.7 2.2 GO:0015182 L-asparagine transmembrane transporter activity(GO:0015182)
0.7 3.4 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.7 8.2 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.6 14.6 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.5 2.1 GO:0051378 serotonin binding(GO:0051378)
0.5 5.3 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.4 5.3 GO:0017081 chloride channel regulator activity(GO:0017081)
0.4 5.6 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.4 2.1 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.4 13.2 GO:0008307 structural constituent of muscle(GO:0008307)
0.4 3.3 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.4 1.5 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.4 1.1 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.3 4.0 GO:0070097 delta-catenin binding(GO:0070097)
0.3 1.3 GO:0004104 cholinesterase activity(GO:0004104) choline binding(GO:0033265)
0.3 6.3 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.3 2.5 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.3 5.4 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.3 6.1 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.3 0.8 GO:0019002 GMP binding(GO:0019002)
0.3 1.1 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.3 4.3 GO:0030228 lipoprotein particle receptor activity(GO:0030228)
0.2 6.0 GO:0016769 transferase activity, transferring nitrogenous groups(GO:0016769)
0.2 5.1 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.2 0.7 GO:0070052 collagen V binding(GO:0070052)
0.2 0.6 GO:0000402 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)
0.2 1.9 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.2 0.6 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.2 0.4 GO:0008432 JUN kinase binding(GO:0008432)
0.2 1.0 GO:0004954 icosanoid receptor activity(GO:0004953) prostanoid receptor activity(GO:0004954) prostaglandin receptor activity(GO:0004955)
0.2 0.6 GO:0008515 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.2 0.8 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.2 1.3 GO:0001515 opioid peptide activity(GO:0001515)
0.2 1.5 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.2 9.6 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.2 1.8 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.2 2.7 GO:0045499 chemorepellent activity(GO:0045499)
0.2 1.0 GO:0070888 E-box binding(GO:0070888)
0.2 2.7 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.2 2.4 GO:0003680 AT DNA binding(GO:0003680)
0.1 1.3 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 2.5 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.1 1.7 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 0.4 GO:0016015 morphogen activity(GO:0016015)
0.1 4.7 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 0.7 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.1 0.5 GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422)
0.1 1.7 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 2.2 GO:0051861 glycolipid binding(GO:0051861)
0.1 1.1 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 0.7 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.1 0.6 GO:0000702 oxidized base lesion DNA N-glycosylase activity(GO:0000702)
0.1 0.8 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.1 1.7 GO:0015197 peptide transporter activity(GO:0015197)
0.1 1.3 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 0.4 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.1 1.2 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 0.7 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1 4.9 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1 10.1 GO:0003727 single-stranded RNA binding(GO:0003727)
0.1 5.0 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.1 0.2 GO:0023029 MHC class Ib protein binding(GO:0023029)
0.1 2.0 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 1.0 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.1 0.4 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.1 1.1 GO:0015643 toxic substance binding(GO:0015643)
0.1 1.2 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.1 0.3 GO:0004090 carbonyl reductase (NADPH) activity(GO:0004090)
0.1 1.3 GO:0016805 dipeptidase activity(GO:0016805)
0.1 1.0 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.1 0.8 GO:0043262 adenosine-diphosphatase activity(GO:0043262)
0.1 0.7 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.1 0.5 GO:0047276 N-acetyllactosaminide 3-alpha-galactosyltransferase activity(GO:0047276)
0.1 0.4 GO:1990188 euchromatin binding(GO:1990188)
0.1 1.2 GO:1990226 histone methyltransferase binding(GO:1990226)
0.1 0.4 GO:0042731 PH domain binding(GO:0042731)
0.1 0.5 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.1 0.2 GO:0004743 pyruvate kinase activity(GO:0004743)
0.1 0.2 GO:0015232 heme transporter activity(GO:0015232)
0.1 1.3 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.1 0.7 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.1 0.3 GO:0051393 alpha-actinin binding(GO:0051393)
0.1 0.1 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 0.8 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 0.6 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.1 0.4 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.1 0.5 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.1 0.4 GO:0097016 L27 domain binding(GO:0097016)
0.1 0.2 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.1 0.2 GO:0032052 bile acid binding(GO:0032052)
0.1 0.2 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
0.1 0.8 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 0.3 GO:0004849 uridine kinase activity(GO:0004849)
0.1 0.2 GO:0019966 interleukin-1 binding(GO:0019966)
0.0 0.9 GO:0070628 proteasome binding(GO:0070628)
0.0 0.1 GO:0035575 histone demethylase activity (H4-K20 specific)(GO:0035575)
0.0 0.5 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.3 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0 5.0 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 0.7 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.9 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.3 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.0 7.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 1.3 GO:0008009 chemokine activity(GO:0008009)
0.0 0.2 GO:0051425 PTB domain binding(GO:0051425)
0.0 0.3 GO:0016004 phospholipase activator activity(GO:0016004) lipase activator activity(GO:0060229)
0.0 1.4 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 2.1 GO:0030507 spectrin binding(GO:0030507)
0.0 3.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.8 GO:0042605 peptide antigen binding(GO:0042605)
0.0 0.5 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.1 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.0 0.3 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0 1.0 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 0.2 GO:0051022 Rho GDP-dissociation inhibitor binding(GO:0051022)
0.0 1.0 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 4.1 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 9.4 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.3 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.3 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 0.1 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.0 0.3 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 0.3 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.7 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.3 GO:0071949 FAD binding(GO:0071949)
0.0 0.1 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.0 0.1 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.0 0.2 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.0 0.3 GO:0004659 prenyltransferase activity(GO:0004659)
0.0 0.5 GO:0030332 cyclin binding(GO:0030332)
0.0 0.3 GO:0015026 coreceptor activity(GO:0015026)
0.0 1.0 GO:0016830 carbon-carbon lyase activity(GO:0016830)
0.0 0.2 GO:0023023 MHC protein complex binding(GO:0023023) MHC class II protein complex binding(GO:0023026)
0.0 0.4 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.2 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.0 0.2 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.2 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.0 1.1 GO:0051287 NAD binding(GO:0051287)
0.0 0.2 GO:0016783 sulfurtransferase activity(GO:0016783)
0.0 0.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.6 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.3 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.7 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 0.2 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.0 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.2 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.0 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0 0.1 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.2 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 0.3 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.0 1.5 GO:0003774 motor activity(GO:0003774)
0.0 0.2 GO:0019239 deaminase activity(GO:0019239)
0.0 0.2 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.3 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.0 GO:0050347 trans-hexaprenyltranstransferase activity(GO:0000010) trans-octaprenyltranstransferase activity(GO:0050347)
0.0 0.3 GO:0030331 estrogen receptor binding(GO:0030331)
0.0 0.1 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.0 1.1 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 14.8 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.5 21.4 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.4 7.5 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.4 2.6 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway
0.3 7.9 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.2 4.7 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.2 6.5 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.2 10.8 NABA_COLLAGENS Genes encoding collagen proteins
0.2 7.0 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.2 5.2 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 12.5 PID_CDC42_PATHWAY CDC42 signaling events
0.1 3.1 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 0.9 ST_TYPE_I_INTERFERON_PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.1 0.4 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.1 6.2 PID_PLK1_PATHWAY PLK1 signaling events
0.1 1.3 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.1 1.8 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.1 3.9 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.1 1.0 PID_ATR_PATHWAY ATR signaling pathway
0.1 0.6 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.1 2.5 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 1.9 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.1 5.1 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 2.9 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 2.9 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.1 0.9 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.1 3.4 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 1.4 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.1 0.9 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.1 3.7 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 0.9 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 0.3 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.5 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 2.1 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.2 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.6 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 6.5 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 0.2 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling
0.0 1.0 PID_ATM_PATHWAY ATM pathway
0.0 0.2 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 1.8 PID_LKB1_PATHWAY LKB1 signaling events
0.0 0.9 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.5 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 1.0 PID_E2F_PATHWAY E2F transcription factor network
0.0 0.4 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.5 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 0.3 PID_IL4_2PATHWAY IL4-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 5.6 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.6 12.8 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.5 12.3 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.3 7.5 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.2 10.8 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.2 3.9 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.2 5.3 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.2 7.7 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.2 2.8 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.2 4.6 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.2 0.8 REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.2 5.3 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.2 1.3 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.2 2.0 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.1 6.9 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 3.7 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 2.2 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.1 1.6 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 1.3 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1 9.5 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 1.1 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.1 7.6 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 5.4 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 1.1 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 2.5 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 4.8 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 5.6 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 0.7 REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.1 0.7 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 1.0 REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT Genes involved in Ligand-gated ion channel transport
0.1 1.8 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.1 1.0 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 0.9 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 4.8 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 0.6 REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.1 0.4 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION_IN_TLR7_8_OR_9_SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 0.8 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 0.5 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.5 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.5 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 5.5 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.7 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.0 0.2 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 1.1 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.7 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.0 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.5 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 2.8 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.6 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.8 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.3 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 0.5 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.4 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
0.0 0.6 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 2.7 REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA Genes involved in Processing of Capped Intron-Containing Pre-mRNA
0.0 0.4 REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.0 0.3 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.6 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import