Motif ID: Srf

Z-value: 1.253


Transcription factors associated with Srf:

Gene SymbolEntrez IDGene Name
Srf ENSMUSG00000015605.5 Srf

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Srfmm10_v2_chr17_-_46556158_46556188-0.391.2e-02Click!


Activity profile for motif Srf.

activity profile for motif Srf


Sorted Z-values histogram for motif Srf

Sorted Z-values for motif Srf



Network of associatons between targets according to the STRING database.



First level regulatory network of Srf

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_+_34861200 12.387 ENSMUST00000165033.1
Egr1
early growth response 1
chr6_-_23248264 11.980 ENSMUST00000031709.5
Fezf1
Fez family zinc finger 1
chr10_-_120899067 10.922 ENSMUST00000092143.5
Msrb3
methionine sulfoxide reductase B3
chr13_+_51846673 6.535 ENSMUST00000021903.2
Gadd45g
growth arrest and DNA-damage-inducible 45 gamma
chr7_-_19310035 5.003 ENSMUST00000003640.2
Fosb
FBJ osteosarcoma oncogene B
chr7_-_44997535 4.461 ENSMUST00000124232.1
ENSMUST00000003290.4
Bcl2l12

BCL2-like 12 (proline rich)

chr3_-_57575907 4.102 ENSMUST00000120977.1
Wwtr1
WW domain containing transcription regulator 1
chr4_+_43957678 3.398 ENSMUST00000107855.1
Glipr2
GLI pathogenesis-related 2
chr12_+_85473883 3.321 ENSMUST00000021674.6
Fos
FBJ osteosarcoma oncogene
chr7_-_137314394 3.209 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
Ebf3



early B cell factor 3



chr4_+_137862237 2.965 ENSMUST00000102518.3
Ece1
endothelin converting enzyme 1
chr7_+_101896340 2.919 ENSMUST00000035395.7
ENSMUST00000106973.1
ENSMUST00000144207.1
Anapc15


anaphase prompoting complex C subunit 15


chr14_+_3049285 2.796 ENSMUST00000166494.1
Gm2897
predicted gene 2897
chr4_+_43957401 2.747 ENSMUST00000030202.7
Glipr2
GLI pathogenesis-related 2
chr14_-_6287250 2.702 ENSMUST00000170104.2
Gm3411
predicted gene 3411
chr14_-_7568566 2.697 ENSMUST00000163790.1
Gm3558
predicted gene 3558
chr14_-_5389049 2.690 ENSMUST00000177986.1
Gm3500
predicted gene 3500
chr11_+_94741782 2.651 ENSMUST00000021240.6
Cdc34-ps
cell division cycle 34 homolog, pseudogene (S. cerevisiae)
chr7_-_44997221 2.632 ENSMUST00000152341.1
Bcl2l12
BCL2-like 12 (proline rich)
chr14_-_5880382 2.470 ENSMUST00000164484.1
Gm8237
predicted gene 8237
chr4_+_132351768 2.430 ENSMUST00000172202.1
Gm17300
predicted gene, 17300
chr14_+_4415448 2.356 ENSMUST00000168866.1
Gm3164
predicted gene 3164
chr2_+_20737306 2.336 ENSMUST00000114606.1
ENSMUST00000114608.1
Etl4

enhancer trap locus 4

chr8_-_47675130 2.300 ENSMUST00000080353.2
Ing2
inhibitor of growth family, member 2
chr14_+_5071040 2.261 ENSMUST00000163719.1
Gm8281
predicted gene, 8281
chr2_-_152415044 2.228 ENSMUST00000099207.3
Zcchc3
zinc finger, CCHC domain containing 3
chr1_-_127677923 2.148 ENSMUST00000160616.1
Tmem163
transmembrane protein 163
chr8_-_47675556 2.089 ENSMUST00000125536.1
Ing2
inhibitor of growth family, member 2
chr8_-_71381907 2.076 ENSMUST00000002466.8
Nr2f6
nuclear receptor subfamily 2, group F, member 6
chr3_-_152266320 2.046 ENSMUST00000046045.8
Nexn
nexilin
chr14_+_4334763 2.009 ENSMUST00000165466.1
2610042L04Rik
RIKEN cDNA 2610042L04 gene
chr14_+_4182576 2.003 ENSMUST00000164512.1
Gm2974
predicted gene 2974
chr4_-_63403330 1.988 ENSMUST00000035724.4
Akna
AT-hook transcription factor
chr14_+_4726775 1.967 ENSMUST00000165619.1
Gm3252
predicted gene 3252
chr10_-_111997204 1.964 ENSMUST00000074805.5
Glipr1
GLI pathogenesis-related 1 (glioma)
chr14_+_3332627 1.914 ENSMUST00000177786.1
Gm2956
predicted gene 2956
chr14_-_6038209 1.903 ENSMUST00000164139.1
Gm8206
predicted gene 8206
chr14_-_6889962 1.893 ENSMUST00000171906.1
Gm3667
predicted gene 3667
chr4_-_132351636 1.884 ENSMUST00000105951.1
Rcc1
regulator of chromosome condensation 1
chr14_-_7315049 1.859 ENSMUST00000165744.1
Gm3739
predicted gene 3739
chr5_-_24329556 1.810 ENSMUST00000115098.2
Kcnh2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr1_-_33757711 1.777 ENSMUST00000044691.7
Bag2
BCL2-associated athanogene 2
chr16_-_24393588 1.775 ENSMUST00000181640.1
1110054M08Rik
RIKEN cDNA 1110054M08 gene
chr7_+_101896817 1.774 ENSMUST00000143835.1
Anapc15
anaphase prompoting complex C subunit 15
chr7_+_44997648 1.772 ENSMUST00000003284.8
ENSMUST00000107835.1
Irf3

interferon regulatory factor 3

chr14_-_5741577 1.746 ENSMUST00000177556.1
Gm3373
predicted gene 3373
chr14_-_5961745 1.742 ENSMUST00000163885.1
Gm3248
predicted gene 3248
chr19_-_4928241 1.666 ENSMUST00000025851.3
Dpp3
dipeptidylpeptidase 3
chr5_-_145191511 1.653 ENSMUST00000161845.1
Atp5j2
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F2
chr14_+_3572023 1.651 ENSMUST00000178728.1
Gm3005
predicted gene 3005
chr14_-_7027449 1.636 ENSMUST00000170738.2
Gm10406
predicted gene 10406
chr1_+_38987806 1.499 ENSMUST00000027247.5
Pdcl3
phosducin-like 3
chr2_+_156775409 1.466 ENSMUST00000088552.6
Myl9
myosin, light polypeptide 9, regulatory
chr6_-_113377510 1.434 ENSMUST00000099118.2
Tada3
transcriptional adaptor 3
chr10_+_67537861 1.413 ENSMUST00000048289.7
ENSMUST00000105438.2
ENSMUST00000130933.1
ENSMUST00000146986.1
Egr2



early growth response 2



chr14_+_4110526 1.385 ENSMUST00000170207.1
Gm8108
predicted gene 8108
chr11_-_101424519 1.355 ENSMUST00000107257.1
ENSMUST00000107259.3
ENSMUST00000107252.2
ENSMUST00000093933.4
Gm27029

Ptges3l

predicted gene, 27029

prostaglandin E synthase 3 (cytosolic)-like

chr6_-_97179100 1.330 ENSMUST00000095664.3
Tmf1
TATA element modulatory factor 1
chr10_-_12861735 1.291 ENSMUST00000076817.4
Utrn
utrophin
chr14_+_3810074 1.263 ENSMUST00000170480.1
Gm3002
predicted gene 3002
chr14_-_6108665 1.231 ENSMUST00000165193.1
Gm3468
predicted gene 3468
chr14_+_3652030 1.211 ENSMUST00000167430.1
Gm3020
predicted gene 3020
chr9_-_66514567 1.205 ENSMUST00000056890.8
Fbxl22
F-box and leucine-rich repeat protein 22
chr14_+_5501674 1.201 ENSMUST00000181562.1
Gm3488
predicted gene, 3488
chr11_+_82911253 1.193 ENSMUST00000164945.1
ENSMUST00000018989.7
Unc45b

unc-45 homolog B (C. elegans)

chr1_-_131097535 1.182 ENSMUST00000016672.4
Mapkapk2
MAP kinase-activated protein kinase 2
chr6_-_113377376 1.171 ENSMUST00000043333.2
Tada3
transcriptional adaptor 3
chr11_+_77462325 1.160 ENSMUST00000102493.1
Coro6
coronin 6
chr19_+_53529100 1.135 ENSMUST00000038287.6
Dusp5
dual specificity phosphatase 5
chr5_+_90367204 1.100 ENSMUST00000068250.3
Gm9958
predicted gene 9958
chr6_+_113378113 1.043 ENSMUST00000171058.1
ENSMUST00000156898.1
Arpc4

actin related protein 2/3 complex, subunit 4

chr14_+_3412614 0.965 ENSMUST00000170123.1
Gm10409
predicted gene 10409
chr11_-_70669283 0.957 ENSMUST00000129434.1
ENSMUST00000018431.6
Spag7

sperm associated antigen 7

chr10_+_79988584 0.942 ENSMUST00000004784.4
ENSMUST00000105374.1
Cnn2

calponin 2

chr5_-_138996087 0.871 ENSMUST00000110897.1
Pdgfa
platelet derived growth factor, alpha
chr3_+_131112785 0.835 ENSMUST00000098611.3
Lef1
lymphoid enhancer binding factor 1
chr14_-_19585135 0.831 ENSMUST00000170694.1
Gm2237
predicted gene 2237
chrX_+_101449078 0.824 ENSMUST00000033674.5
Itgb1bp2
integrin beta 1 binding protein 2
chr14_+_74732384 0.804 ENSMUST00000176957.1
Esd
esterase D/formylglutathione hydrolase
chr12_-_110696289 0.790 ENSMUST00000021698.6
Hsp90aa1
heat shock protein 90, alpha (cytosolic), class A member 1
chr14_-_7174533 0.789 ENSMUST00000172431.1
Gm3512
predicted gene 3512
chr11_-_120348475 0.746 ENSMUST00000062147.7
ENSMUST00000128055.1
Actg1

actin, gamma, cytoplasmic 1

chr6_-_113377866 0.740 ENSMUST00000032410.7
Tada3
transcriptional adaptor 3
chr13_+_23746734 0.735 ENSMUST00000099703.2
Hist1h2bb
histone cluster 1, H2bb
chr1_+_167618246 0.723 ENSMUST00000111380.1
Rxrg
retinoid X receptor gamma
chr12_-_32953772 0.707 ENSMUST00000180391.1
ENSMUST00000181670.1
4933406C10Rik

RIKEN cDNA 4933406C10 gene

chr1_+_74391479 0.696 ENSMUST00000027367.7
Ctdsp1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr19_+_25406661 0.693 ENSMUST00000146647.1
Kank1
KN motif and ankyrin repeat domains 1
chr19_-_5912771 0.655 ENSMUST00000118623.1
Dpf2
D4, zinc and double PHD fingers family 2
chr14_+_4855576 0.644 ENSMUST00000166776.1
Gm3264
predicted gene 3264
chr2_+_125068118 0.618 ENSMUST00000070353.3
Slc24a5
solute carrier family 24, member 5
chr11_-_69662625 0.543 ENSMUST00000018905.5
Mpdu1
mannose-P-dolichol utilization defect 1
chr3_+_90072641 0.543 ENSMUST00000121503.1
ENSMUST00000119570.1
ENSMUST00000062193.9
Tpm3


tropomyosin 3, gamma


chr3_+_106113229 0.530 ENSMUST00000079132.5
ENSMUST00000139086.1
Chia

chitinase, acidic

chr8_-_84237042 0.501 ENSMUST00000039480.5
Zswim4
zinc finger SWIM-type containing 4
chr11_-_120348513 0.475 ENSMUST00000071555.6
Actg1
actin, gamma, cytoplasmic 1
chr11_-_120348091 0.394 ENSMUST00000106215.4
Actg1
actin, gamma, cytoplasmic 1
chr14_+_20929416 0.393 ENSMUST00000022369.7
Vcl
vinculin
chr1_+_63176818 0.388 ENSMUST00000129339.1
Eef1b2
eukaryotic translation elongation factor 1 beta 2
chr19_-_5912834 0.387 ENSMUST00000136983.1
Dpf2
D4, zinc and double PHD fingers family 2
chr11_-_69662564 0.381 ENSMUST00000129224.1
ENSMUST00000155200.1
Mpdu1

mannose-P-dolichol utilization defect 1

chr2_+_143915273 0.356 ENSMUST00000103172.3
Dstn
destrin
chr2_+_127336152 0.347 ENSMUST00000028846.6
Dusp2
dual specificity phosphatase 2
chr12_-_110696248 0.312 ENSMUST00000124156.1
Hsp90aa1
heat shock protein 90, alpha (cytosolic), class A member 1
chr5_+_30588078 0.297 ENSMUST00000066295.2
Kcnk3
potassium channel, subfamily K, member 3
chr17_+_7925990 0.275 ENSMUST00000036370.7
Tagap
T cell activation Rho GTPase activating protein
chr14_-_34502663 0.265 ENSMUST00000049005.8
Bmpr1a
bone morphogenetic protein receptor, type 1A
chr12_-_110695860 0.236 ENSMUST00000149189.1
Hsp90aa1
heat shock protein 90, alpha (cytosolic), class A member 1
chr2_-_60881360 0.215 ENSMUST00000164147.1
ENSMUST00000112509.1
Rbms1

RNA binding motif, single stranded interacting protein 1

chr15_-_77842133 0.211 ENSMUST00000016771.6
Myh9
myosin, heavy polypeptide 9, non-muscle
chr5_-_142905816 0.207 ENSMUST00000171419.1
Actb
actin, beta
chr11_-_120731944 0.150 ENSMUST00000154565.1
ENSMUST00000026148.2
Cbr2

carbonyl reductase 2

chr15_-_36794498 0.100 ENSMUST00000110361.1
ENSMUST00000022894.7
ENSMUST00000110359.1
Ywhaz


tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide


chr3_-_95891938 0.088 ENSMUST00000036360.6
ENSMUST00000090476.3
BC028528

cDNA sequence BC028528

chr7_+_128246812 0.085 ENSMUST00000164710.1
ENSMUST00000070656.5
Tgfb1i1

transforming growth factor beta 1 induced transcript 1

chr17_-_46153517 0.073 ENSMUST00000171172.1
Mad2l1bp
MAD2L1 binding protein
chr10_+_45335751 0.062 ENSMUST00000095715.3
Bves
blood vessel epicardial substance
chr17_-_27204357 0.041 ENSMUST00000055117.7
Lemd2
LEM domain containing 2
chr7_+_120677579 0.022 ENSMUST00000060175.6
BC030336
cDNA sequence BC030336
chr7_+_128246953 0.018 ENSMUST00000167965.1
Tgfb1i1
transforming growth factor beta 1 induced transcript 1
chr2_+_164833781 0.017 ENSMUST00000143780.1
Ctsa
cathepsin A
chr17_+_23803179 0.004 ENSMUST00000088621.4
Srrm2
serine/arginine repetitive matrix 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.1 12.4 GO:0072223 metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
2.7 10.9 GO:0030091 protein repair(GO:0030091)
2.0 12.0 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.0 3.0 GO:0010814 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.9 4.4 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.7 7.1 GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166)
0.7 6.5 GO:0042095 interferon-gamma biosynthetic process(GO:0042095)
0.6 4.1 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.5 2.0 GO:0060025 regulation of synaptic activity(GO:0060025)
0.4 1.3 GO:2000836 positive regulation of androgen secretion(GO:2000836) positive regulation of testosterone secretion(GO:2000845)
0.4 1.8 GO:0050689 negative regulation of interferon-beta biosynthetic process(GO:0045358) negative regulation of defense response to virus by host(GO:0050689)
0.4 0.9 GO:0035793 negative regulation of phosphatidylinositol biosynthetic process(GO:0010512) cell migration involved in metanephros development(GO:0035788) metanephric mesenchymal cell migration(GO:0035789) positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:0035793) regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:1900238) regulation of metanephric mesenchymal cell migration(GO:2000589) positive regulation of metanephric mesenchymal cell migration(GO:2000591)
0.4 1.3 GO:0007525 somatic muscle development(GO:0007525)
0.3 4.7 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.3 1.8 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.3 1.5 GO:0008616 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.3 0.8 GO:0032714 negative regulation of interleukin-13 production(GO:0032696) negative regulation of interleukin-5 production(GO:0032714) trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) odontoblast differentiation(GO:0071895) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
0.3 2.0 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.2 2.2 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.2 1.4 GO:0021593 rhombomere morphogenesis(GO:0021593)
0.2 0.7 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.2 1.3 GO:0045583 regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585)
0.2 0.8 GO:0046294 formaldehyde catabolic process(GO:0046294)
0.2 1.2 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535) macropinocytosis(GO:0044351)
0.2 3.3 GO:0035994 response to muscle stretch(GO:0035994)
0.2 0.6 GO:1900377 negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377)
0.1 2.1 GO:0050965 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.1 6.2 GO:0010718 positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.1 5.0 GO:0071277 cellular response to calcium ion(GO:0071277)
0.1 0.4 GO:0030043 actin filament fragmentation(GO:0030043)
0.1 0.9 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.1 1.1 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.1 3.8 GO:0070527 platelet aggregation(GO:0070527)
0.1 0.2 GO:0006116 NADH oxidation(GO:0006116)
0.0 0.9 GO:0050765 negative regulation of phagocytosis(GO:0050765)
0.0 1.9 GO:0051290 protein heterotetramerization(GO:0051290)
0.0 0.3 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 1.0 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 1.7 GO:0006754 ATP biosynthetic process(GO:0006754)
0.0 0.7 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 2.3 GO:0048706 embryonic skeletal system development(GO:0048706)
0.0 0.1 GO:0002553 histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553) Golgi reassembly(GO:0090168)
0.0 1.2 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.0 1.5 GO:0006457 protein folding(GO:0006457)
0.0 0.3 GO:0001706 endoderm formation(GO:0001706)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 4.4 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.6 3.0 GO:0033093 Weibel-Palade body(GO:0033093)
0.6 3.3 GO:0035976 AP1 complex(GO:0035976)
0.5 1.8 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.3 1.3 GO:0097226 sperm mitochondrial sheath(GO:0097226)
0.2 4.7 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 2.2 GO:0000124 SAGA complex(GO:0000124)
0.1 1.7 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 1.5 GO:0070938 contractile ring(GO:0070938)
0.1 2.1 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 1.0 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 1.5 GO:0016460 myosin II complex(GO:0016460)
0.1 0.8 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.1 0.4 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 2.0 GO:0043034 costamere(GO:0043034)
0.0 0.5 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 1.1 GO:0030018 Z disc(GO:0030018)
0.0 1.0 GO:0090544 BAF-type complex(GO:0090544)
0.0 1.9 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 6.1 GO:0000139 Golgi membrane(GO:0000139)
0.0 1.2 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.7 GO:0000786 nucleosome(GO:0000786)
0.0 0.9 GO:0005902 microvillus(GO:0005902)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 12.4 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
1.8 10.9 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.4 1.8 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.3 1.9 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.3 1.7 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.3 0.8 GO:0018738 S-formylglutathione hydrolase activity(GO:0018738)
0.2 1.5 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.2 1.3 GO:0002135 CTP binding(GO:0002135) sulfonylurea receptor binding(GO:0017098)
0.2 1.8 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 0.8 GO:0030284 estrogen receptor activity(GO:0030284)
0.1 1.5 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 0.6 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.1 1.5 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 1.2 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 2.6 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 3.3 GO:0070412 R-SMAD binding(GO:0070412)
0.1 0.7 GO:0008420 CTD phosphatase activity(GO:0008420)
0.1 7.1 GO:0002039 p53 binding(GO:0002039)
0.1 1.3 GO:0017166 vinculin binding(GO:0017166)
0.1 0.7 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 4.4 GO:0035064 methylated histone binding(GO:0035064)
0.1 2.2 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.1 0.9 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 10.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 1.4 GO:0071837 HMG box domain binding(GO:0071837)
0.0 2.1 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0 0.1 GO:0098973 structural constituent of synapse(GO:0098918) structural constituent of postsynaptic actin cytoskeleton(GO:0098973)
0.0 2.7 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.4 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.2 GO:0004090 carbonyl reductase (NADPH) activity(GO:0004090)
0.0 11.1 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 3.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.2 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 0.3 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.4 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.2 GO:0043495 protein anchor(GO:0043495)
0.0 0.1 GO:0048495 Roundabout binding(GO:0048495)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 12.4 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.2 3.3 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.2 6.5 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.1 1.3 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 1.4 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 1.6 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.1 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 2.7 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 0.8 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.0 1.5 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 0.7 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.0 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 0.7 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.9 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.9 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.0 0.4 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 0.8 PID_CMYB_PATHWAY C-MYB transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 14.2 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.2 3.3 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 4.1 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.1 1.7 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 1.2 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events
0.1 2.4 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 1.3 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 1.8 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.3 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 2.8 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.7 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 1.4 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.9 REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS Genes involved in Host Interactions of HIV factors