Motif ID: Mef2c

Z-value: 0.784


Transcription factors associated with Mef2c:

Gene SymbolEntrez IDGene Name
Mef2c ENSMUSG00000005583.10 Mef2c

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mef2cmm10_v2_chr13_+_83573577_835736070.525.2e-04Click!


Activity profile for motif Mef2c.

activity profile for motif Mef2c


Sorted Z-values histogram for motif Mef2c

Sorted Z-values for motif Mef2c



Network of associatons between targets according to the STRING database.



First level regulatory network of Mef2c

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_144892813 6.556 ENSMUST00000105744.1
ENSMUST00000171001.1
Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr12_-_34528844 5.943 ENSMUST00000110819.2
Hdac9
histone deacetylase 9
chr19_-_5802640 5.313 ENSMUST00000173523.1
ENSMUST00000173499.1
ENSMUST00000172812.2
Malat1


metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)


chr4_+_144893077 5.263 ENSMUST00000154208.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr10_+_69785507 4.681 ENSMUST00000182993.1
Ank3
ankyrin 3, epithelial
chr4_+_144893127 4.582 ENSMUST00000142808.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chrX_-_51681703 3.608 ENSMUST00000088172.5
Hs6st2
heparan sulfate 6-O-sulfotransferase 2
chr3_-_85722474 3.595 ENSMUST00000119077.1
Fam160a1
family with sequence similarity 160, member A1
chrX_-_51681856 3.534 ENSMUST00000114871.1
Hs6st2
heparan sulfate 6-O-sulfotransferase 2
chr5_+_66745835 3.440 ENSMUST00000101164.4
ENSMUST00000118242.1
ENSMUST00000119854.1
ENSMUST00000117601.1
Limch1



LIM and calponin homology domains 1



chr13_+_16011851 3.289 ENSMUST00000042603.6
Inhba
inhibin beta-A
chr5_+_75152274 3.268 ENSMUST00000000476.8
Pdgfra
platelet derived growth factor receptor, alpha polypeptide
chr6_+_108213086 3.188 ENSMUST00000032192.6
Itpr1
inositol 1,4,5-trisphosphate receptor 1
chr5_-_122002340 3.030 ENSMUST00000134326.1
Cux2
cut-like homeobox 2
chr13_+_83573577 2.806 ENSMUST00000185052.1
Mef2c
myocyte enhancer factor 2C
chr1_-_64122256 2.771 ENSMUST00000135075.1
Klf7
Kruppel-like factor 7 (ubiquitous)
chr14_+_101840602 2.738 ENSMUST00000159314.1
Lmo7
LIM domain only 7
chr16_+_45093611 2.674 ENSMUST00000099498.2
Ccdc80
coiled-coil domain containing 80
chr14_+_101840501 2.640 ENSMUST00000159026.1
Lmo7
LIM domain only 7
chr7_+_91090728 2.610 ENSMUST00000074273.3
Dlg2
discs, large homolog 2 (Drosophila)
chr7_+_91090697 2.609 ENSMUST00000107196.2
Dlg2
discs, large homolog 2 (Drosophila)
chr2_-_77703252 2.492 ENSMUST00000171063.1
Zfp385b
zinc finger protein 385B
chr7_+_130865835 2.334 ENSMUST00000075181.4
ENSMUST00000048180.5
Plekha1

pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1

chr7_+_112742025 2.210 ENSMUST00000164363.1
Tead1
TEA domain family member 1
chr16_+_7069825 2.197 ENSMUST00000056416.7
Rbfox1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr12_+_88953399 2.057 ENSMUST00000057634.7
Nrxn3
neurexin III
chr7_+_130865756 2.047 ENSMUST00000120441.1
Plekha1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr14_-_64455903 1.986 ENSMUST00000067927.7
Msra
methionine sulfoxide reductase A
chr17_-_67950908 1.904 ENSMUST00000164647.1
Arhgap28
Rho GTPase activating protein 28
chr12_+_71048338 1.901 ENSMUST00000135709.1
Arid4a
AT rich interactive domain 4A (RBP1-like)
chr3_-_158562199 1.893 ENSMUST00000106044.1
Lrrc7
leucine rich repeat containing 7
chr14_+_66344296 1.746 ENSMUST00000152093.1
ENSMUST00000074523.6
Stmn4

stathmin-like 4

chr19_+_4003334 1.743 ENSMUST00000025806.3
Doc2g
double C2, gamma
chr6_+_58831748 1.736 ENSMUST00000126292.1
ENSMUST00000031823.5
Herc3

hect domain and RLD 3

chr5_+_66968559 1.721 ENSMUST00000127184.1
Limch1
LIM and calponin homology domains 1
chr4_+_156215920 1.720 ENSMUST00000105572.1
2310042D19Rik
RIKEN cDNA 2310042D19 gene
chr3_-_56183678 1.689 ENSMUST00000029374.6
Nbea
neurobeachin
chr9_-_101198999 1.662 ENSMUST00000066773.7
Ppp2r3a
protein phosphatase 2, regulatory subunit B'', alpha
chr7_-_67372846 1.658 ENSMUST00000156690.1
ENSMUST00000107476.1
ENSMUST00000076325.5
ENSMUST00000032776.8
ENSMUST00000133074.1
Mef2a




myocyte enhancer factor 2A




chr5_+_105519388 1.625 ENSMUST00000067924.6
ENSMUST00000150981.1
Lrrc8c

leucine rich repeat containing 8 family, member C

chr14_+_66344369 1.616 ENSMUST00000118426.1
ENSMUST00000121955.1
ENSMUST00000120229.1
ENSMUST00000134440.1
Stmn4



stathmin-like 4



chr18_+_45268876 1.610 ENSMUST00000183850.1
ENSMUST00000066890.7
Kcnn2

potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2

chr5_+_107497762 1.591 ENSMUST00000152474.1
ENSMUST00000060553.7
A830010M20Rik

RIKEN cDNA A830010M20 gene

chr11_+_3330401 1.545 ENSMUST00000045153.4
Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr14_-_54781886 1.534 ENSMUST00000022787.6
Slc7a8
solute carrier family 7 (cationic amino acid transporter, y+ system), member 8
chr5_+_19907774 1.533 ENSMUST00000115267.2
Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr1_+_63445842 1.521 ENSMUST00000087374.3
ENSMUST00000114107.1
ENSMUST00000182642.1
Adam23


a disintegrin and metallopeptidase domain 23


chr1_-_64121389 1.473 ENSMUST00000055001.3
Klf7
Kruppel-like factor 7 (ubiquitous)
chr11_-_120630516 1.456 ENSMUST00000106181.1
Mafg
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian)
chr10_+_69925484 1.445 ENSMUST00000182692.1
ENSMUST00000092433.5
Ank3

ankyrin 3, epithelial

chr15_+_101266839 1.424 ENSMUST00000023779.6
Nr4a1
nuclear receptor subfamily 4, group A, member 1
chr10_+_69925766 1.424 ENSMUST00000182269.1
ENSMUST00000183261.1
ENSMUST00000183074.1
Ank3


ankyrin 3, epithelial


chr5_-_111761697 1.414 ENSMUST00000129146.1
ENSMUST00000137398.1
ENSMUST00000129065.1
E130006D01Rik


RIKEN cDNA E130006D01 gene


chr10_+_69925800 1.413 ENSMUST00000182029.1
Ank3
ankyrin 3, epithelial
chr8_-_71671723 1.391 ENSMUST00000177517.1
ENSMUST00000030170.8
Unc13a

unc-13 homolog A (C. elegans)

chr1_+_180109192 1.364 ENSMUST00000143176.1
ENSMUST00000135056.1
Cdc42bpa

CDC42 binding protein kinase alpha

chr5_+_107497718 1.361 ENSMUST00000112671.2
A830010M20Rik
RIKEN cDNA A830010M20 gene
chr12_+_83987854 1.360 ENSMUST00000021649.7
Acot2
acyl-CoA thioesterase 2
chr10_+_69925954 1.352 ENSMUST00000181974.1
ENSMUST00000182795.1
ENSMUST00000182437.1
Ank3


ankyrin 3, epithelial


chr10_+_90576872 1.339 ENSMUST00000182550.1
ENSMUST00000099364.5
Anks1b

ankyrin repeat and sterile alpha motif domain containing 1B

chr5_-_123141067 1.335 ENSMUST00000162697.1
ENSMUST00000160321.1
ENSMUST00000159637.1
AI480526


expressed sequence AI480526


chr6_+_42286709 1.309 ENSMUST00000163936.1
Clcn1
chloride channel 1
chr4_+_130308595 1.284 ENSMUST00000070532.7
Fabp3
fatty acid binding protein 3, muscle and heart
chr2_+_48949495 1.237 ENSMUST00000112745.1
Mbd5
methyl-CpG binding domain protein 5
chr6_+_42286676 1.234 ENSMUST00000031894.6
Clcn1
chloride channel 1
chr5_+_66968416 1.225 ENSMUST00000038188.7
Limch1
LIM and calponin homology domains 1
chr2_-_91255995 1.216 ENSMUST00000180732.1
Gm17281
predicted gene, 17281
chr4_+_99829437 1.207 ENSMUST00000124547.1
ENSMUST00000106994.1
Efcab7

EF-hand calcium binding domain 7

chr3_+_103279293 1.200 ENSMUST00000029444.6
ENSMUST00000106860.1
Trim33

tripartite motif-containing 33

chr1_-_134234492 1.180 ENSMUST00000169927.1
Adora1
adenosine A1 receptor
chr7_+_30121915 1.167 ENSMUST00000098596.3
ENSMUST00000153792.1
Zfp382

zinc finger protein 382

chr15_-_89425795 1.143 ENSMUST00000168376.1
Cpt1b
carnitine palmitoyltransferase 1b, muscle
chr12_+_52699297 1.121 ENSMUST00000095737.3
Akap6
A kinase (PRKA) anchor protein 6
chr13_-_74363993 1.081 ENSMUST00000022064.4
Lrrc14b
leucine rich repeat containing 14B
chr5_-_62765618 1.074 ENSMUST00000159470.1
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr11_-_120630126 1.066 ENSMUST00000106180.1
Mafg
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian)
chr1_-_88702121 1.063 ENSMUST00000159814.1
Arl4c
ADP-ribosylation factor-like 4C
chr2_+_69670100 1.059 ENSMUST00000100050.3
Klhl41
kelch-like 41
chr10_-_69212996 1.055 ENSMUST00000170048.1
A930033H14Rik
RIKEN cDNA A930033H14 gene
chr2_-_104028287 1.044 ENSMUST00000056170.3
4931422A03Rik
RIKEN cDNA 4931422A03 gene
chr8_-_41016749 1.037 ENSMUST00000117735.1
Mtus1
mitochondrial tumor suppressor 1
chr16_+_14705832 1.029 ENSMUST00000023356.6
Snai2
snail homolog 2 (Drosophila)
chrX_+_6577259 1.003 ENSMUST00000089520.2
Shroom4
shroom family member 4
chr3_-_49757257 0.986 ENSMUST00000035931.7
Pcdh18
protocadherin 18
chr1_+_75375271 0.898 ENSMUST00000087122.5
Speg
SPEG complex locus
chr9_+_74953053 0.881 ENSMUST00000170846.1
Fam214a
family with sequence similarity 214, member A
chr13_-_59556845 0.864 ENSMUST00000170378.1
ENSMUST00000169434.1
Agtpbp1

ATP/GTP binding protein 1

chr1_-_64121456 0.856 ENSMUST00000142009.1
ENSMUST00000114086.1
Klf7

Kruppel-like factor 7 (ubiquitous)

chr2_-_164833438 0.856 ENSMUST00000042775.4
Neurl2
neuralized-like 2 (Drosophila)
chr2_+_91256144 0.838 ENSMUST00000154959.1
ENSMUST00000059566.4
Pacsin3

protein kinase C and casein kinase substrate in neurons 3

chr11_+_77462325 0.835 ENSMUST00000102493.1
Coro6
coronin 6
chr19_-_46327121 0.835 ENSMUST00000041391.4
ENSMUST00000096029.5
Psd

pleckstrin and Sec7 domain containing

chr11_+_31872100 0.829 ENSMUST00000020543.6
ENSMUST00000109412.2
Cpeb4

cytoplasmic polyadenylation element binding protein 4

chr4_+_82065855 0.822 ENSMUST00000151038.1
Gm5860
predicted gene 5860
chr9_-_119093468 0.817 ENSMUST00000010804.2
Plcd1
phospholipase C, delta 1
chr2_+_3513035 0.812 ENSMUST00000036350.2
Cdnf
cerebral dopamine neurotrophic factor
chr9_-_112232449 0.807 ENSMUST00000035085.5
Arpp21
cyclic AMP-regulated phosphoprotein, 21
chr13_-_113663670 0.803 ENSMUST00000054650.4
Hspb3
heat shock protein 3
chr11_-_69369377 0.783 ENSMUST00000092971.6
ENSMUST00000108661.1
Chd3

chromodomain helicase DNA binding protein 3

chr2_-_33086366 0.768 ENSMUST00000049618.2
Garnl3
GTPase activating RANGAP domain-like 3
chr6_-_128124312 0.723 ENSMUST00000127105.1
Tspan9
tetraspanin 9
chr11_+_20647149 0.709 ENSMUST00000109585.1
Sertad2
SERTA domain containing 2
chr2_-_77170592 0.707 ENSMUST00000164114.2
ENSMUST00000049544.7
Ccdc141

coiled-coil domain containing 141

chr7_-_45366714 0.705 ENSMUST00000107779.1
Ppfia3
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr11_+_54304005 0.704 ENSMUST00000000145.5
ENSMUST00000138515.1
Acsl6

acyl-CoA synthetase long-chain family member 6

chr19_-_37176055 0.698 ENSMUST00000142973.1
ENSMUST00000154376.1
Cpeb3

cytoplasmic polyadenylation element binding protein 3

chr6_-_142702259 0.679 ENSMUST00000073173.5
ENSMUST00000111771.1
ENSMUST00000087527.4
ENSMUST00000100827.2
Abcc9



ATP-binding cassette, sub-family C (CFTR/MRP), member 9



chr2_-_67433181 0.672 ENSMUST00000180773.1
Gm26727
predicted gene, 26727
chr1_+_180851131 0.643 ENSMUST00000038091.6
Sde2
SDE2 telomere maintenance homolog (S. pombe)
chr2_+_91255954 0.637 ENSMUST00000134699.1
Pacsin3
protein kinase C and casein kinase substrate in neurons 3
chr17_+_44188564 0.637 ENSMUST00000024755.5
Clic5
chloride intracellular channel 5
chr14_-_93888732 0.634 ENSMUST00000068992.2
Pcdh9
protocadherin 9
chr4_-_41048124 0.633 ENSMUST00000030136.6
Aqp7
aquaporin 7
chr9_-_7872983 0.632 ENSMUST00000115672.1
Birc3
baculoviral IAP repeat-containing 3
chrX_-_47892502 0.612 ENSMUST00000077569.4
ENSMUST00000101616.2
ENSMUST00000088973.4
Smarca1


SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1


chr13_-_107890059 0.601 ENSMUST00000105097.2
Zswim6
zinc finger SWIM-type containing 6
chr3_-_129755305 0.587 ENSMUST00000029653.2
Egf
epidermal growth factor
chr8_+_93810832 0.586 ENSMUST00000034198.8
ENSMUST00000125716.1
Gnao1

guanine nucleotide binding protein, alpha O

chrX_-_47892396 0.584 ENSMUST00000153548.2
Smarca1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
chr4_+_137862270 0.578 ENSMUST00000130407.1
Ece1
endothelin converting enzyme 1
chr3_+_116562965 0.570 ENSMUST00000029573.5
Lrrc39
leucine rich repeat containing 39
chr11_+_54303798 0.570 ENSMUST00000093106.5
Acsl6
acyl-CoA synthetase long-chain family member 6
chr14_+_69029289 0.559 ENSMUST00000014957.8
Stc1
stanniocalcin 1
chr19_+_38264761 0.546 ENSMUST00000087252.5
Lgi1
leucine-rich repeat LGI family, member 1
chr9_-_42457594 0.507 ENSMUST00000125995.1
Tbcel
tubulin folding cofactor E-like
chr12_+_69241832 0.507 ENSMUST00000063445.6
Klhdc1
kelch domain containing 1
chr3_+_68584154 0.497 ENSMUST00000182997.1
Schip1
schwannomin interacting protein 1
chr2_-_168712853 0.488 ENSMUST00000123156.1
ENSMUST00000156555.1
Atp9a

ATPase, class II, type 9A

chr18_-_35498856 0.478 ENSMUST00000025215.8
Sil1
endoplasmic reticulum chaperone SIL1 homolog (S. cerevisiae)
chr2_-_48949206 0.472 ENSMUST00000090976.3
ENSMUST00000149679.1
ENSMUST00000028098.4
Orc4


origin recognition complex, subunit 4


chr13_-_85127514 0.461 ENSMUST00000179230.1
Gm4076
predicted gene 4076
chr3_+_51693771 0.448 ENSMUST00000099104.2
Gm10729
predicted gene 10729
chr11_+_54304180 0.432 ENSMUST00000108904.3
ENSMUST00000108905.3
Acsl6

acyl-CoA synthetase long-chain family member 6

chr2_-_32694120 0.424 ENSMUST00000028148.4
Fpgs
folylpolyglutamyl synthetase
chr18_-_38918642 0.419 ENSMUST00000040647.4
Fgf1
fibroblast growth factor 1
chr8_+_40307458 0.409 ENSMUST00000068999.7
Micu3
mitochondrial calcium uptake family, member 3
chr16_-_44016387 0.398 ENSMUST00000036174.3
Gramd1c
GRAM domain containing 1C
chr4_+_49059256 0.386 ENSMUST00000076670.2
E130309F12Rik
RIKEN cDNA E130309F12 gene
chr18_+_67464849 0.382 ENSMUST00000025411.7
Slmo1
slowmo homolog 1 (Drosophila)
chr4_+_46039202 0.352 ENSMUST00000156200.1
Tmod1
tropomodulin 1
chr11_+_77801325 0.342 ENSMUST00000151373.2
ENSMUST00000172303.2
ENSMUST00000130305.2
ENSMUST00000164334.1
ENSMUST00000092884.4
Myo18a




myosin XVIIIA




chr2_+_118663235 0.339 ENSMUST00000099557.3
Pak6
p21 protein (Cdc42/Rac)-activated kinase 6
chr2_+_32628390 0.293 ENSMUST00000156578.1
Ak1
adenylate kinase 1
chr7_-_115846080 0.277 ENSMUST00000166207.1
Sox6
SRY-box containing gene 6
chr5_-_129879038 0.273 ENSMUST00000026617.6
Phkg1
phosphorylase kinase gamma 1
chr1_-_172219715 0.252 ENSMUST00000170700.1
ENSMUST00000003554.4
Casq1

calsequestrin 1

chr1_+_131827977 0.247 ENSMUST00000086559.6
Slc41a1
solute carrier family 41, member 1
chr7_+_122671378 0.226 ENSMUST00000182563.1
Cacng3
calcium channel, voltage-dependent, gamma subunit 3
chr9_+_55326913 0.219 ENSMUST00000085754.3
ENSMUST00000034862.4
AI118078

expressed sequence AI118078

chr11_+_70657687 0.208 ENSMUST00000134087.1
ENSMUST00000170716.1
Eno3

enolase 3, beta muscle

chr4_+_11485947 0.201 ENSMUST00000055372.7
ENSMUST00000059914.6
1110037F02Rik

RIKEN cDNA 1110037F02 gene

chr1_+_59482133 0.189 ENSMUST00000114246.2
ENSMUST00000037105.6
Fzd7

frizzled homolog 7 (Drosophila)

chr4_+_62663620 0.183 ENSMUST00000126338.1
Rgs3
regulator of G-protein signaling 3
chr18_-_25753852 0.172 ENSMUST00000025117.6
ENSMUST00000115816.2
Celf4

CUGBP, Elav-like family member 4

chr4_+_82065924 0.167 ENSMUST00000161588.1
Gm5860
predicted gene 5860
chrX_-_59567348 0.163 ENSMUST00000124402.1
Fgf13
fibroblast growth factor 13
chr3_-_65958236 0.159 ENSMUST00000029416.7
Ccnl1
cyclin L1
chr11_+_70657196 0.155 ENSMUST00000157027.1
ENSMUST00000072841.5
ENSMUST00000108548.1
ENSMUST00000126241.1
Eno3



enolase 3, beta muscle



chr18_-_3281036 0.127 ENSMUST00000049942.6
ENSMUST00000139537.1
ENSMUST00000124747.1
Crem


cAMP responsive element modulator


chr11_-_102218923 0.123 ENSMUST00000131254.1
Hdac5
histone deacetylase 5
chr17_-_45592262 0.093 ENSMUST00000164769.1
Slc29a1
solute carrier family 29 (nucleoside transporters), member 1
chr2_+_178193075 0.092 ENSMUST00000103065.1
Phactr3
phosphatase and actin regulator 3
chr18_+_76059458 0.090 ENSMUST00000167921.1
Zbtb7c
zinc finger and BTB domain containing 7C
chr3_-_51340628 0.084 ENSMUST00000062009.7
Elf2
E74-like factor 2
chr6_+_112273758 0.072 ENSMUST00000032376.5
Lmcd1
LIM and cysteine-rich domains 1
chrX_-_64276937 0.062 ENSMUST00000114679.1
ENSMUST00000069926.7
Slitrk4

SLIT and NTRK-like family, member 4

chr15_-_89425856 0.061 ENSMUST00000109313.2
Cpt1b
carnitine palmitoyltransferase 1b, muscle
chrX_-_59568068 0.043 ENSMUST00000119833.1
ENSMUST00000131319.1
Fgf13

fibroblast growth factor 13

chr13_+_23934434 0.022 ENSMUST00000072391.1
Hist1h2aa
histone cluster 1, H2aa
chr17_-_45592569 0.022 ENSMUST00000163492.1
Slc29a1
solute carrier family 29 (nucleoside transporters), member 1
chr3_-_51340555 0.017 ENSMUST00000091144.4
Elf2
E74-like factor 2
chr15_+_25940846 0.015 ENSMUST00000110438.1
Fam134b
family with sequence similarity 134, member B
chr11_-_107716517 0.010 ENSMUST00000021065.5
Cacng1
calcium channel, voltage-dependent, gamma subunit 1
chr11_+_120232921 0.002 ENSMUST00000122148.1
ENSMUST00000044985.7
Bahcc1

BAH domain and coiled-coil containing 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 16.4 GO:0042572 retinol metabolic process(GO:0042572)
1.2 7.1 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
1.1 3.3 GO:0035790 platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790)
1.1 5.3 GO:0035063 nuclear speck organization(GO:0035063)
0.9 10.3 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.9 2.8 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
0.7 5.9 GO:0034983 peptidyl-lysine deacetylation(GO:0034983)
0.7 3.3 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.6 1.7 GO:0007525 somatic muscle development(GO:0007525)
0.6 1.7 GO:0070375 ERK5 cascade(GO:0070375)
0.5 1.0 GO:1901420 negative regulation of response to alcohol(GO:1901420)
0.5 1.9 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.4 1.2 GO:0060399 positive regulation of growth hormone receptor signaling pathway(GO:0060399)
0.4 1.2 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256)
0.4 4.9 GO:0001553 luteinization(GO:0001553)
0.4 5.2 GO:0045161 neuronal ion channel clustering(GO:0045161)
0.4 3.2 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.3 1.6 GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914)
0.3 1.3 GO:2001245 regulation of phosphatidylcholine biosynthetic process(GO:2001245)
0.3 1.9 GO:0034773 histone H4-K20 trimethylation(GO:0034773) establishment of Sertoli cell barrier(GO:0097368)
0.3 1.7 GO:0010747 positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747)
0.3 2.5 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.3 1.1 GO:2000481 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316) positive regulation of cAMP-dependent protein kinase activity(GO:2000481)
0.2 0.7 GO:0002182 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.2 1.4 GO:0099525 presynaptic dense core granule exocytosis(GO:0099525)
0.2 1.5 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.2 0.9 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.2 2.2 GO:0014883 transition between fast and slow fiber(GO:0014883)
0.2 1.5 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.2 0.8 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701) positive regulation of inositol trisphosphate biosynthetic process(GO:0032962)
0.1 2.1 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.1 0.4 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.1 0.4 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.1 3.0 GO:0007614 short-term memory(GO:0007614)
0.1 0.6 GO:0002024 diet induced thermogenesis(GO:0002024)
0.1 0.2 GO:0071286 cellular response to magnesium ion(GO:0071286)
0.1 0.6 GO:0090370 negative regulation of cholesterol efflux(GO:0090370) positive regulation of hyaluronan biosynthetic process(GO:1900127)
0.1 1.3 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.1 1.4 GO:0061469 regulation of type B pancreatic cell proliferation(GO:0061469)
0.1 2.0 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)
0.1 0.6 GO:0015840 urea transport(GO:0015840)
0.1 0.8 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.1 0.3 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.1 0.6 GO:0060536 cartilage morphogenesis(GO:0060536)
0.1 0.4 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.1 0.6 GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
0.1 0.6 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.1 1.5 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 3.6 GO:0007019 microtubule depolymerization(GO:0007019)
0.1 1.0 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 1.7 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.3 GO:0046103 ADP biosynthetic process(GO:0006172) inosine biosynthetic process(GO:0046103)
0.0 0.2 GO:2000383 regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384)
0.0 1.4 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.0 0.7 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 1.5 GO:0015804 neutral amino acid transport(GO:0015804)
0.0 1.0 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.0 6.8 GO:0031032 actomyosin structure organization(GO:0031032)
0.0 0.8 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 2.5 GO:0030641 regulation of cellular pH(GO:0030641)
0.0 2.5 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.0 0.2 GO:1902866 regulation of retina development in camera-type eye(GO:1902866)
0.0 0.2 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0 1.2 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.0 4.0 GO:0048813 dendrite morphogenesis(GO:0048813)
0.0 0.7 GO:0021799 cerebral cortex radially oriented cell migration(GO:0021799)
0.0 0.2 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0 0.9 GO:0043044 ATP-dependent chromatin remodeling(GO:0043044)
0.0 0.2 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.0 0.6 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.0 0.1 GO:0015862 uridine transport(GO:0015862)
0.0 1.2 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 1.3 GO:0006892 post-Golgi vesicle-mediated transport(GO:0006892)
0.0 0.5 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.5 GO:0006270 DNA replication initiation(GO:0006270)
0.0 0.1 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.3 GO:0043512 inhibin A complex(GO:0043512)
1.1 3.2 GO:0031088 platelet dense granule membrane(GO:0031088)
0.6 2.2 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.5 10.3 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.3 1.2 GO:0090537 CERF complex(GO:0090537)
0.3 0.9 GO:0005927 muscle tendon junction(GO:0005927)
0.3 1.4 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
0.3 5.2 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.2 0.7 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.2 2.7 GO:0005614 interstitial matrix(GO:0005614)
0.1 1.1 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 2.2 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 0.3 GO:0014802 terminal cisterna(GO:0014802)
0.1 1.9 GO:0043194 axon initial segment(GO:0043194)
0.1 0.7 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.1 1.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 3.1 GO:0034707 chloride channel complex(GO:0034707)
0.1 1.2 GO:0010369 chromocenter(GO:0010369)
0.1 1.5 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 5.8 GO:0035097 histone methyltransferase complex(GO:0035097)
0.1 1.2 GO:0032279 asymmetric synapse(GO:0032279)
0.1 0.5 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 5.2 GO:0032587 ruffle membrane(GO:0032587)
0.0 1.6 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 0.8 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.4 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.3 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 0.3 GO:0001520 outer dense fiber(GO:0001520)
0.0 0.8 GO:0016528 sarcoplasm(GO:0016528)
0.0 2.1 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.7 GO:0048786 presynaptic active zone(GO:0048786)
0.0 2.7 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 1.0 GO:0031941 filamentous actin(GO:0031941)
0.0 0.6 GO:0032420 stereocilium(GO:0032420)
0.0 5.2 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.4 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 1.3 GO:0005902 microvillus(GO:0005902)
0.0 2.9 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 0.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 1.4 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 3.0 GO:0000139 Golgi membrane(GO:0000139)
0.0 0.8 GO:0017053 transcriptional repressor complex(GO:0017053)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 16.4 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
1.8 7.1 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
1.1 3.2 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.8 4.8 GO:0070699 type II activin receptor binding(GO:0070699)
0.7 2.0 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.7 3.3 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.5 1.5 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.4 1.6 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.4 1.2 GO:0070615 nucleosome-dependent ATPase activity(GO:0070615)
0.3 1.3 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.2 1.2 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.2 5.2 GO:0004385 guanylate kinase activity(GO:0004385)
0.2 4.7 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.2 11.7 GO:0030507 spectrin binding(GO:0030507)
0.2 2.8 GO:0003680 AT DNA binding(GO:0003680)
0.2 4.4 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.2 1.5 GO:0019534 toxin transporter activity(GO:0019534)
0.2 1.2 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609) heterotrimeric G-protein binding(GO:0032795)
0.2 2.5 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.2 0.6 GO:0015254 glycerol channel activity(GO:0015254)
0.1 1.6 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.1 4.9 GO:0042805 actinin binding(GO:0042805)
0.1 1.5 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.1 2.7 GO:0001968 fibronectin binding(GO:0001968)
0.1 1.5 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.1 0.6 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.1 1.7 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.1 1.4 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.1 0.8 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.1 1.1 GO:0043495 protein anchor(GO:0043495)
0.1 1.2 GO:0070410 co-SMAD binding(GO:0070410)
0.1 2.1 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 1.7 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 1.4 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.4 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.4 GO:0044548 S100 protein binding(GO:0044548)
0.0 1.7 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.4 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.3 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.0 0.8 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.5 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 1.7 GO:0051018 protein kinase A binding(GO:0051018)
0.0 0.8 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.3 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 0.5 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.5 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.4 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 1.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.7 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 0.4 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 1.0 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.2 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.6 GO:0005254 chloride channel activity(GO:0005254)
0.0 1.0 GO:0008083 growth factor activity(GO:0008083)
0.0 0.4 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 1.3 GO:0030674 protein binding, bridging(GO:0030674)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 15.9 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 3.2 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 7.5 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.1 3.3 PID_ALK1_PATHWAY ALK1 signaling events
0.1 2.2 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.1 3.7 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.1 0.6 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.1 0.6 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 1.3 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.1 PID_ARF6_PATHWAY Arf6 signaling events
0.0 2.2 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 0.6 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 1.2 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.9 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.4 PID_CDC42_PATHWAY CDC42 signaling events
0.0 0.8 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 0.3 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.0 0.4 PID_FGF_PATHWAY FGF signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.3 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.3 10.3 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 7.1 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 0.6 REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING Genes involved in SHC1 events in EGFR signaling
0.1 4.2 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.1 1.2 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.1 0.6 REACTOME_PLC_BETA_MEDIATED_EVENTS Genes involved in PLC beta mediated events
0.1 2.1 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 1.7 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 1.2 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.1 0.4 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.1 1.2 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.5 REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.0 1.5 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 2.6 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 4.7 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION Genes involved in Downstream signal transduction
0.0 0.3 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 0.6 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 2.5 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.4 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.5 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.3 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates