Motif ID: Onecut1_Cux2

Z-value: 1.248

Transcription factors associated with Onecut1_Cux2:

Gene SymbolEntrez IDGene Name
Cux2 ENSMUSG00000042589.12 Cux2
Cux2 ENSMUSG00000072641.1 Cux2
Onecut1 ENSMUSG00000043013.9 Onecut1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Onecut1mm10_v2_chr9_+_74861888_748619210.595.1e-05Click!
Cux2mm10_v2_chr5_-_122049822_122049882-0.296.8e-02Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Onecut1_Cux2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_23248264 26.690 ENSMUST00000031709.5
Fezf1
Fez family zinc finger 1
chr3_+_102010138 14.598 ENSMUST00000066187.4
Nhlh2
nescient helix loop helix 2
chr12_+_55598917 10.069 ENSMUST00000051857.3
Insm2
insulinoma-associated 2
chr14_+_68083853 9.879 ENSMUST00000022639.7
Nefl
neurofilament, light polypeptide
chr12_+_72441933 8.081 ENSMUST00000161284.1
Lrrc9
leucine rich repeat containing 9
chr1_-_158958367 7.720 ENSMUST00000159861.2
Pappa2
pappalysin 2
chr6_+_4755327 6.555 ENSMUST00000176551.1
Peg10
paternally expressed 10
chr10_-_64090265 6.057 ENSMUST00000105439.1
Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr12_+_72441852 5.805 ENSMUST00000162159.1
Lrrc9
leucine rich repeat containing 9
chr10_-_64090241 5.315 ENSMUST00000133588.1
Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr18_-_72351029 4.694 ENSMUST00000114943.3
Dcc
deleted in colorectal carcinoma
chr18_-_72351009 4.659 ENSMUST00000073379.5
Dcc
deleted in colorectal carcinoma
chr8_+_58911755 4.518 ENSMUST00000062978.6
BC030500
cDNA sequence BC030500
chrX_+_134404780 4.023 ENSMUST00000113224.2
ENSMUST00000113226.1
Drp2

dystrophin related protein 2

chr3_+_125404072 3.931 ENSMUST00000173932.1
Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr9_-_50739365 3.910 ENSMUST00000117093.1
ENSMUST00000121634.1
Dixdc1

DIX domain containing 1

chrX_+_134404543 3.788 ENSMUST00000113228.1
ENSMUST00000153424.1
Drp2

dystrophin related protein 2

chr1_+_165302625 3.622 ENSMUST00000111450.1
Gpr161
G protein-coupled receptor 161
chr10_-_112928974 3.438 ENSMUST00000099276.2
Atxn7l3b
ataxin 7-like 3B
chr7_+_35802593 3.430 ENSMUST00000052454.2
E130304I02Rik
RIKEN cDNA E130304I02 gene
chr3_+_125404292 3.392 ENSMUST00000144344.1
Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr8_-_58911627 3.368 ENSMUST00000077447.4
Galntl6
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6
chr3_+_8509477 3.091 ENSMUST00000029002.7
Stmn2
stathmin-like 2
chrX_-_43274786 2.775 ENSMUST00000016294.7
Tenm1
teneurin transmembrane protein 1
chr4_+_62965560 2.633 ENSMUST00000030043.6
ENSMUST00000107415.1
ENSMUST00000064814.5
Zfp618


zinc finger protein 618


chr3_-_33082004 2.256 ENSMUST00000108225.3
Pex5l
peroxisomal biogenesis factor 5-like
chr1_-_54194048 2.085 ENSMUST00000120904.1
Hecw2
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
chr19_-_37178011 2.084 ENSMUST00000133988.1
Cpeb3
cytoplasmic polyadenylation element binding protein 3
chr2_-_72986716 2.019 ENSMUST00000112062.1
Gm11084
predicted gene 11084
chr2_-_84775388 1.989 ENSMUST00000023994.3
Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr7_+_25152456 1.977 ENSMUST00000098678.1
D930028M14Rik
RIKEN cDNA D930028M14 gene
chrX_+_56609751 1.876 ENSMUST00000144068.1
Slc9a6
solute carrier family 9 (sodium/hydrogen exchanger), member 6
chr1_-_89933290 1.871 ENSMUST00000036954.7
Gbx2
gastrulation brain homeobox 2
chr8_+_127064107 1.770 ENSMUST00000162536.1
ENSMUST00000026921.6
ENSMUST00000162665.1
ENSMUST00000160766.1
ENSMUST00000162602.1
ENSMUST00000162531.1
ENSMUST00000160581.1
ENSMUST00000161355.1
ENSMUST00000159537.1
Pard3








par-3 (partitioning defective 3) homolog (C. elegans)








chr9_+_59589288 1.741 ENSMUST00000121266.1
ENSMUST00000118164.1
Celf6

CUGBP, Elav-like family member 6

chr8_+_127064022 1.663 ENSMUST00000160272.1
ENSMUST00000079777.5
ENSMUST00000162907.1
Pard3


par-3 (partitioning defective 3) homolog (C. elegans)


chr13_+_93304940 1.569 ENSMUST00000109497.1
ENSMUST00000109498.1
ENSMUST00000060490.4
ENSMUST00000109492.1
ENSMUST00000109496.1
ENSMUST00000109495.1
Homer1





homer homolog 1 (Drosophila)





chr9_+_54980880 1.498 ENSMUST00000093844.3
Chrna5
cholinergic receptor, nicotinic, alpha polypeptide 5
chr1_+_191717834 1.486 ENSMUST00000110855.1
ENSMUST00000133076.1
Lpgat1

lysophosphatidylglycerol acyltransferase 1

chr13_+_93304799 1.485 ENSMUST00000080127.5
Homer1
homer homolog 1 (Drosophila)
chr12_-_46818749 1.479 ENSMUST00000021438.6
Nova1
neuro-oncological ventral antigen 1
chr11_+_120232921 1.455 ENSMUST00000122148.1
ENSMUST00000044985.7
Bahcc1

BAH domain and coiled-coil containing 1

chr2_-_84775420 1.402 ENSMUST00000111641.1
Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr5_+_63649335 1.305 ENSMUST00000159584.1
3110047P20Rik
RIKEN cDNA 3110047P20 gene
chr7_+_45627482 1.294 ENSMUST00000057927.7
Rasip1
Ras interacting protein 1
chr14_-_55092277 1.275 ENSMUST00000036328.8
Zfhx2
zinc finger homeobox 2
chr7_-_127448993 1.174 ENSMUST00000106299.1
Zfp689
zinc finger protein 689
chr6_+_29853746 1.142 ENSMUST00000064872.6
ENSMUST00000152581.1
ENSMUST00000176265.1
ENSMUST00000154079.1
Ahcyl2



S-adenosylhomocysteine hydrolase-like 2



chr4_-_97584605 1.098 ENSMUST00000107067.1
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr4_-_97584612 1.078 ENSMUST00000107068.2
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr8_-_8660773 1.073 ENSMUST00000001319.7
Efnb2
ephrin B2
chr4_+_109343029 1.057 ENSMUST00000030281.5
Eps15
epidermal growth factor receptor pathway substrate 15
chr18_+_35965088 1.023 ENSMUST00000175734.1
Psd2
pleckstrin and Sec7 domain containing 2
chr2_-_168767136 1.015 ENSMUST00000029061.5
ENSMUST00000103074.1
Sall4

sal-like 4 (Drosophila)

chr7_-_127449109 1.010 ENSMUST00000053392.4
Zfp689
zinc finger protein 689
chr18_+_35965036 0.944 ENSMUST00000176873.1
ENSMUST00000177432.1
Psd2

pleckstrin and Sec7 domain containing 2

chr9_-_29963112 0.923 ENSMUST00000075069.4
Ntm
neurotrimin
chr2_-_32451396 0.872 ENSMUST00000028160.8
ENSMUST00000113310.2
Slc25a25

solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25

chr3_+_5218516 0.855 ENSMUST00000175866.1
Zfhx4
zinc finger homeodomain 4
chr2_+_163602331 0.849 ENSMUST00000152135.1
Ttpal
tocopherol (alpha) transfer protein-like
chr2_+_163602294 0.810 ENSMUST00000171696.1
ENSMUST00000109408.3
Ttpal

tocopherol (alpha) transfer protein-like

chr8_-_79399513 0.793 ENSMUST00000066091.7
ENSMUST00000109885.1
ENSMUST00000066081.3
Smad1


SMAD family member 1


chr7_+_51880312 0.780 ENSMUST00000145049.1
Gas2
growth arrest specific 2
chr17_+_55986494 0.740 ENSMUST00000011733.8
Fsd1
fibronectin type 3 and SPRY domain-containing protein
chr1_-_54438940 0.740 ENSMUST00000041638.6
Gtf3c3
general transcription factor IIIC, polypeptide 3
chr15_-_42676967 0.704 ENSMUST00000022921.5
Angpt1
angiopoietin 1
chr2_-_7081207 0.690 ENSMUST00000114923.2
ENSMUST00000182706.1
Celf2

CUGBP, Elav-like family member 2

chr2_-_7081256 0.690 ENSMUST00000183209.1
Celf2
CUGBP, Elav-like family member 2
chr3_+_94372794 0.643 ENSMUST00000029795.3
Rorc
RAR-related orphan receptor gamma
chr16_+_32430895 0.609 ENSMUST00000115137.1
ENSMUST00000079791.4
Pcyt1a

phosphate cytidylyltransferase 1, choline, alpha isoform

chr16_+_32431225 0.607 ENSMUST00000115140.1
Pcyt1a
phosphate cytidylyltransferase 1, choline, alpha isoform
chr2_-_60963192 0.561 ENSMUST00000028347.6
Rbms1
RNA binding motif, single stranded interacting protein 1
chr17_-_71459300 0.516 ENSMUST00000183937.1
Gm4707
predicted gene 4707
chr15_-_103215285 0.498 ENSMUST00000122182.1
ENSMUST00000108813.3
ENSMUST00000127191.1
Cbx5


chromobox 5


chr19_-_32061438 0.491 ENSMUST00000096119.4
Asah2
N-acylsphingosine amidohydrolase 2
chr11_+_97315716 0.490 ENSMUST00000019026.3
ENSMUST00000132168.1
Mrpl45

mitochondrial ribosomal protein L45

chr13_-_54688246 0.475 ENSMUST00000122935.1
ENSMUST00000128257.1
Rnf44

ring finger protein 44

chr11_+_4902212 0.464 ENSMUST00000142543.1
Thoc5
THO complex 5
chr18_+_12972225 0.458 ENSMUST00000025290.5
Impact
imprinted and ancient
chr3_-_129755305 0.359 ENSMUST00000029653.2
Egf
epidermal growth factor
chr4_-_46991842 0.355 ENSMUST00000107749.2
Gabbr2
gamma-aminobutyric acid (GABA) B receptor, 2
chr11_-_120624973 0.328 ENSMUST00000106183.2
ENSMUST00000080202.5
Sirt7

sirtuin 7

chr8_+_113643206 0.296 ENSMUST00000034219.4
ENSMUST00000095173.1
Syce1l

synaptonemal complex central element protein 1 like

chr19_-_57197377 0.272 ENSMUST00000111546.1
Ablim1
actin-binding LIM protein 1
chr2_-_92392634 0.266 ENSMUST00000111279.2
Mapk8ip1
mitogen-activated protein kinase 8 interacting protein 1
chr5_+_92683625 0.260 ENSMUST00000168878.1
Shroom3
shroom family member 3
chr7_+_75848338 0.242 ENSMUST00000092073.5
ENSMUST00000171155.2
Klhl25

kelch-like 25

chr5_+_144100387 0.223 ENSMUST00000041804.7
Lmtk2
lemur tyrosine kinase 2
chr4_-_110292719 0.220 ENSMUST00000106601.1
Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chrM_+_14138 0.219 ENSMUST00000082421.1
mt-Cytb
mitochondrially encoded cytochrome b
chr19_+_31082841 0.211 ENSMUST00000066039.6
Cstf2t
cleavage stimulation factor, 3' pre-RNA subunit 2, tau
chr17_-_24479034 0.192 ENSMUST00000179163.1
ENSMUST00000070888.6
Mlst8

MTOR associated protein, LST8 homolog (S. cerevisiae)

chr3_+_5218589 0.179 ENSMUST00000177488.1
Zfhx4
zinc finger homeodomain 4
chr7_-_116084635 0.149 ENSMUST00000111755.3
Gm4353
predicted gene 4353
chr3_+_5218546 0.135 ENSMUST00000026284.6
Zfhx4
zinc finger homeodomain 4
chrX_-_51205990 0.108 ENSMUST00000114876.2
Mbnl3
muscleblind-like 3 (Drosophila)
chr1_-_51941261 0.090 ENSMUST00000097103.3
Gm8420
predicted gene 8420

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.4 26.7 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
3.3 9.9 GO:0045110 intermediate filament bundle assembly(GO:0045110)
1.6 9.4 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)
1.1 3.4 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
1.0 3.1 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.8 11.4 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.7 2.1 GO:0002182 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.6 3.4 GO:0003383 apical constriction(GO:0003383)
0.5 14.6 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.4 1.2 GO:0006657 CDP-choline pathway(GO:0006657)
0.3 3.6 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.3 2.3 GO:0051461 protein import into peroxisome matrix, docking(GO:0016560) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.3 3.9 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.3 1.9 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.2 0.7 GO:0030210 heparin biosynthetic process(GO:0030210) Tie signaling pathway(GO:0048014)
0.2 3.1 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.2 1.9 GO:0031547 brain-derived neurotrophic factor receptor signaling pathway(GO:0031547)
0.2 1.5 GO:0035095 behavioral response to nicotine(GO:0035095)
0.2 0.5 GO:0032058 positive regulation of translational initiation in response to stress(GO:0032058)
0.1 1.1 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.1 1.1 GO:1903847 regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.1 0.8 GO:0002051 osteoblast fate commitment(GO:0002051)
0.1 1.1 GO:0019065 receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
0.1 6.6 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.1 1.5 GO:0031507 heterochromatin assembly(GO:0031507)
0.1 1.5 GO:0045723 positive regulation of fatty acid biosynthetic process(GO:0045723)
0.1 0.4 GO:0007262 STAT protein import into nucleus(GO:0007262)
0.1 0.3 GO:0045896 regulation of transcription during mitosis(GO:0045896) positive regulation of transcription during mitosis(GO:0045897)
0.1 0.6 GO:0072615 interleukin-17 secretion(GO:0072615)
0.1 2.0 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 0.5 GO:0045650 negative regulation of macrophage differentiation(GO:0045650) negative regulation of DNA damage checkpoint(GO:2000002)
0.1 2.8 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.1 6.8 GO:0060349 bone morphogenesis(GO:0060349)
0.1 1.7 GO:0071625 vocalization behavior(GO:0071625)
0.1 1.0 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.1 0.3 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.3 GO:0007128 meiotic prophase I(GO:0007128) prophase(GO:0051324)
0.0 0.2 GO:0033762 response to glucagon(GO:0033762)
0.0 0.9 GO:0014823 response to activity(GO:0014823)
0.0 2.1 GO:0030071 regulation of mitotic metaphase/anaphase transition(GO:0030071) regulation of metaphase/anaphase transition of cell cycle(GO:1902099)
0.0 1.4 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.2 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.0 0.2 GO:0033572 transferrin transport(GO:0033572)
0.0 1.3 GO:0010507 negative regulation of autophagy(GO:0010507)
0.0 1.0 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 0.4 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 1.5 GO:0050684 regulation of mRNA processing(GO:0050684)
0.0 3.8 GO:0050808 synapse organization(GO:0050808)
0.0 0.5 GO:0006665 sphingolipid metabolic process(GO:0006665)
0.0 0.4 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 9.9 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.9 9.4 GO:0032584 growth cone membrane(GO:0032584)
0.6 2.3 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.4 3.4 GO:0033269 internode region of axon(GO:0033269)
0.3 1.9 GO:0044308 axonal spine(GO:0044308)
0.1 1.5 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 1.2 GO:0042587 glycogen granule(GO:0042587)
0.1 1.5 GO:0005677 chromatin silencing complex(GO:0005677)
0.1 2.1 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 0.7 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.1 0.3 GO:0044302 dentate gyrus mossy fiber(GO:0044302)
0.1 0.4 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.1 1.1 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 17.9 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 0.5 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 2.0 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 3.8 GO:0055037 recycling endosome(GO:0055037)
0.0 0.5 GO:0010369 chromocenter(GO:0010369)
0.0 3.9 GO:0043679 axon terminus(GO:0043679)
0.0 2.1 GO:0072686 mitotic spindle(GO:0072686)
0.0 0.8 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.2 GO:0045275 respiratory chain complex III(GO:0045275)
0.0 0.2 GO:0031931 TORC1 complex(GO:0031931)
0.0 1.4 GO:0072562 blood microparticle(GO:0072562)
0.0 0.2 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.2 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.3 GO:0000795 synaptonemal complex(GO:0000795)
0.0 8.5 GO:0005794 Golgi apparatus(GO:0005794)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 9.4 GO:0005042 netrin receptor activity(GO:0005042)
1.0 7.3 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.5 2.3 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.4 9.9 GO:0043274 phospholipase binding(GO:0043274)
0.3 3.1 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.2 1.2 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.2 1.9 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.2 14.6 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.2 0.7 GO:0000995 transcription factor activity, core RNA polymerase III binding(GO:0000995)
0.2 1.1 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.2 0.6 GO:0008142 oxysterol binding(GO:0008142)
0.1 1.5 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 2.1 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 24.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 4.2 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.1 11.4 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 0.8 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)
0.1 7.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 0.9 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.1 0.3 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739)
0.1 0.5 GO:0017040 ceramidase activity(GO:0017040)
0.1 3.4 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 3.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 2.0 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 0.7 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.1 0.4 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.1 10.1 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 1.7 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.0 3.1 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.2 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 1.4 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 1.1 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 13.3 GO:0008270 zinc ion binding(GO:0008270)
0.0 1.1 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 0.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 2.6 GO:0061659 ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0 2.0 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.0 0.2 GO:0017091 AU-rich element binding(GO:0017091)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 9.4 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 11.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 0.8 PID_ALK2_PATHWAY ALK2 signaling events
0.1 6.6 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 3.4 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.0 1.1 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 3.9 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.4 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 0.7 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.9 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.3 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.5 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.8 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 0.3 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 9.4 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.5 7.7 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.4 9.9 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.3 3.4 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.2 7.3 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.2 1.5 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 1.5 REACTOME_ACYL_CHAIN_REMODELLING_OF_PG Genes involved in Acyl chain remodelling of PG
0.1 3.4 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 3.4 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 1.4 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.7 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.8 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.4 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.7 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_2_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.0 0.4 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.0 0.5 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.2 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling