Motif ID: Trp53

Z-value: 1.013


Transcription factors associated with Trp53:

Gene SymbolEntrez IDGene Name
Trp53 ENSMUSG00000059552.7 Trp53

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Trp53mm10_v2_chr11_+_69580359_69580382-0.182.6e-01Click!


Activity profile for motif Trp53.

activity profile for motif Trp53


Sorted Z-values histogram for motif Trp53

Sorted Z-values for motif Trp53



Network of associatons between targets according to the STRING database.



First level regulatory network of Trp53

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_98004695 9.644 ENSMUST00000023123.8
Col2a1
collagen, type II, alpha 1
chr15_-_98004634 9.635 ENSMUST00000131560.1
ENSMUST00000088355.5
Col2a1

collagen, type II, alpha 1

chr17_+_29090969 8.623 ENSMUST00000119901.1
Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr1_+_6487231 6.013 ENSMUST00000140079.1
ENSMUST00000131494.1
St18

suppression of tumorigenicity 18

chr17_-_33890584 5.982 ENSMUST00000114361.2
ENSMUST00000173492.1
Kifc1

kinesin family member C1

chr10_+_56377300 5.748 ENSMUST00000068581.7
Gja1
gap junction protein, alpha 1
chr2_-_69206146 5.615 ENSMUST00000127243.1
ENSMUST00000149643.1
ENSMUST00000167875.2
ENSMUST00000005365.8
Spc25



SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)



chr17_-_33890539 4.976 ENSMUST00000173386.1
Kifc1
kinesin family member C1
chr14_-_34374617 4.886 ENSMUST00000023826.4
Sncg
synuclein, gamma
chr2_-_69206133 4.848 ENSMUST00000112320.1
Spc25
SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr8_-_22185758 4.281 ENSMUST00000046916.7
Ckap2
cytoskeleton associated protein 2
chr15_+_85859689 3.901 ENSMUST00000170629.1
Gtse1
G two S phase expressed protein 1
chr9_+_45138437 3.652 ENSMUST00000060125.5
Scn4b
sodium channel, type IV, beta
chr9_-_106158109 3.580 ENSMUST00000159809.1
ENSMUST00000162562.1
ENSMUST00000036382.6
ENSMUST00000112543.2
Glyctk



glycerate kinase



chr11_-_3527916 3.490 ENSMUST00000020718.4
Smtn
smoothelin
chr17_+_87282880 3.404 ENSMUST00000041110.5
ENSMUST00000125875.1
Ttc7

tetratricopeptide repeat domain 7

chr4_-_135573623 3.183 ENSMUST00000105855.1
Grhl3
grainyhead-like 3 (Drosophila)
chr9_+_66946057 3.146 ENSMUST00000040917.7
ENSMUST00000127896.1
Rps27l

ribosomal protein S27-like

chr11_-_102925086 3.112 ENSMUST00000021311.9
Kif18b
kinesin family member 18B
chr14_+_47001336 3.035 ENSMUST00000125113.1
Samd4
sterile alpha motif domain containing 4
chr14_+_73237891 2.994 ENSMUST00000044405.6
Lpar6
lysophosphatidic acid receptor 6
chr15_-_102350692 2.905 ENSMUST00000041208.7
Aaas
achalasia, adrenocortical insufficiency, alacrimia
chr10_+_93641041 2.879 ENSMUST00000020204.4
Ntn4
netrin 4
chr11_-_17211504 2.867 ENSMUST00000020317.7
Pno1
partner of NOB1 homolog (S. cerevisiae)
chr8_+_68880491 2.861 ENSMUST00000015712.8
Lpl
lipoprotein lipase
chr17_+_35821675 2.802 ENSMUST00000003635.6
Ier3
immediate early response 3
chr5_-_30073554 2.679 ENSMUST00000026846.6
Tyms
thymidylate synthase
chr2_-_155074447 2.677 ENSMUST00000137242.1
ENSMUST00000054607.9
Ahcy

S-adenosylhomocysteine hydrolase

chr4_+_116596672 2.669 ENSMUST00000051869.7
Ccdc17
coiled-coil domain containing 17
chr1_-_79858627 2.587 ENSMUST00000027467.4
Serpine2
serine (or cysteine) peptidase inhibitor, clade E, member 2
chr7_-_98309471 2.534 ENSMUST00000033020.7
Acer3
alkaline ceramidase 3
chr9_-_100486788 2.365 ENSMUST00000098458.3
Il20rb
interleukin 20 receptor beta
chr5_-_115194283 2.237 ENSMUST00000112113.1
Cabp1
calcium binding protein 1
chr13_+_113317084 2.144 ENSMUST00000136755.2
BC067074
cDNA sequence BC067074
chr17_+_26917091 2.041 ENSMUST00000078961.4
Kifc5b
kinesin family member C5B
chr14_+_74735641 2.006 ENSMUST00000177283.1
Esd
esterase D/formylglutathione hydrolase
chr11_-_93968242 1.984 ENSMUST00000107844.2
Nme1
NME/NM23 nucleoside diphosphate kinase 1
chr7_-_114927726 1.824 ENSMUST00000059737.2
Gm6816
predicted gene 6816
chr4_+_132351768 1.799 ENSMUST00000172202.1
Gm17300
predicted gene, 17300
chr4_-_9643638 1.794 ENSMUST00000108333.1
ENSMUST00000108334.1
ENSMUST00000108335.1
ENSMUST00000152526.1
ENSMUST00000103004.3
Asph




aspartate-beta-hydroxylase




chr11_-_93968293 1.752 ENSMUST00000170303.1
Gm20390
predicted gene 20390
chr9_-_114982739 1.703 ENSMUST00000053150.5
Gm9846
predicted gene 9846
chr13_-_22035589 1.702 ENSMUST00000091742.4
Hist1h2ah
histone cluster 1, H2ah
chr16_+_20651652 1.647 ENSMUST00000007212.8
Psmd2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
chr13_+_21754067 1.628 ENSMUST00000091709.2
Hist1h2bn
histone cluster 1, H2bn
chr4_-_43030440 1.627 ENSMUST00000135660.1
Stoml2
stomatin (Epb7.2)-like 2
chr14_-_103843685 1.585 ENSMUST00000172237.1
Ednrb
endothelin receptor type B
chr7_+_24884809 1.545 ENSMUST00000156372.1
ENSMUST00000124035.1
Rps19

ribosomal protein S19

chr10_-_81350389 1.529 ENSMUST00000020454.4
ENSMUST00000105324.2
ENSMUST00000154609.2
ENSMUST00000105323.1
Hmg20b



high mobility group 20B



chr10_+_94550852 1.516 ENSMUST00000148910.1
ENSMUST00000117460.1
Tmcc3

transmembrane and coiled coil domains 3

chr13_+_22035821 1.464 ENSMUST00000110455.2
Hist1h2bk
histone cluster 1, H2bk
chr10_+_110745433 1.456 ENSMUST00000174857.1
ENSMUST00000073781.5
ENSMUST00000173471.1
ENSMUST00000173634.1
E2f7



E2F transcription factor 7



chr16_-_59632520 1.452 ENSMUST00000118438.1
Arl6
ADP-ribosylation factor-like 6
chr10_-_81350191 1.423 ENSMUST00000122993.1
Hmg20b
high mobility group 20B
chr4_+_115057683 1.358 ENSMUST00000161601.1
Tal1
T cell acute lymphocytic leukemia 1
chr2_-_164857542 1.355 ENSMUST00000109316.1
ENSMUST00000156255.1
ENSMUST00000128110.1
ENSMUST00000109317.3
Pltp



phospholipid transfer protein



chr5_+_114707760 1.335 ENSMUST00000094441.4
Tchp
trichoplein, keratin filament binding
chr8_+_94977101 1.315 ENSMUST00000179619.1
Gpr56
G protein-coupled receptor 56
chr9_-_72985344 1.312 ENSMUST00000124565.2
Gm5918
predicted gene 5918
chr9_+_72438519 1.310 ENSMUST00000184604.1
Mns1
meiosis-specific nuclear structural protein 1
chr15_+_83100281 1.302 ENSMUST00000167389.1
ENSMUST00000166427.1
Serhl

serine hydrolase-like

chr9_+_72438534 1.282 ENSMUST00000034746.8
Mns1
meiosis-specific nuclear structural protein 1
chr8_-_111854278 1.275 ENSMUST00000034432.5
Cfdp1
craniofacial development protein 1
chr18_+_66458587 1.269 ENSMUST00000025399.7
Pmaip1
phorbol-12-myristate-13-acetate-induced protein 1
chr10_-_81350305 1.267 ENSMUST00000167481.1
Hmg20b
high mobility group 20B
chr7_-_64872993 1.233 ENSMUST00000094331.2
Ndnl2
necdin-like 2
chr5_-_138272733 1.225 ENSMUST00000161665.1
ENSMUST00000100530.1
Gal3st4

galactose-3-O-sulfotransferase 4

chrX_+_74254782 1.217 ENSMUST00000119197.1
ENSMUST00000088313.4
Emd

emerin

chr6_-_136941494 1.209 ENSMUST00000111892.1
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr9_-_70141484 1.125 ENSMUST00000034749.8
Fam81a
family with sequence similarity 81, member A
chr7_+_24884651 1.113 ENSMUST00000153451.2
ENSMUST00000108429.1
Rps19

ribosomal protein S19

chr4_+_115057410 1.105 ENSMUST00000136946.1
Tal1
T cell acute lymphocytic leukemia 1
chr6_+_128438757 1.096 ENSMUST00000144745.1
Gm10069
predicted gene 10069
chr5_-_138272786 1.091 ENSMUST00000161279.1
ENSMUST00000161647.1
Gal3st4

galactose-3-O-sulfotransferase 4

chr7_+_24884611 1.076 ENSMUST00000108428.1
Rps19
ribosomal protein S19
chr15_+_83100201 1.061 ENSMUST00000078218.4
Serhl
serine hydrolase-like
chr6_-_136941694 1.056 ENSMUST00000032344.5
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr2_+_59612034 1.037 ENSMUST00000112568.1
ENSMUST00000037526.4
Tanc1

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

chr2_+_29890063 1.013 ENSMUST00000028128.6
Odf2
outer dense fiber of sperm tails 2
chr6_+_134981998 0.978 ENSMUST00000167323.1
Apold1
apolipoprotein L domain containing 1
chr2_+_29889217 0.954 ENSMUST00000123335.1
Odf2
outer dense fiber of sperm tails 2
chr10_+_80622677 0.932 ENSMUST00000079773.6
Csnk1g2
casein kinase 1, gamma 2
chr1_+_161969179 0.921 ENSMUST00000111594.2
ENSMUST00000028021.6
Pigc

phosphatidylinositol glycan anchor biosynthesis, class C

chr17_-_34862473 0.902 ENSMUST00000025229.4
ENSMUST00000176203.2
ENSMUST00000128767.1
Cfb


complement factor B


chr3_+_96172327 0.900 ENSMUST00000076372.4
Sf3b4
splicing factor 3b, subunit 4
chr11_+_52360824 0.900 ENSMUST00000102758.1
Vdac1
voltage-dependent anion channel 1
chrX_-_38635066 0.880 ENSMUST00000058265.7
C1galt1c1
C1GALT1-specific chaperone 1
chr14_-_55944536 0.874 ENSMUST00000022834.6
Cma1
chymase 1, mast cell
chr5_-_116422858 0.863 ENSMUST00000036991.4
Hspb8
heat shock protein 8
chr7_+_75455534 0.819 ENSMUST00000147005.1
ENSMUST00000166315.1
Akap13

A kinase (PRKA) anchor protein 13

chr11_+_88204396 0.808 ENSMUST00000118784.1
ENSMUST00000139170.1
ENSMUST00000107915.3
ENSMUST00000144070.1
Mrps23



mitochondrial ribosomal protein S23



chr2_+_72285637 0.806 ENSMUST00000090824.5
ENSMUST00000135469.1
Zak

sterile alpha motif and leucine zipper containing kinase AZK

chr6_-_136941887 0.784 ENSMUST00000111891.1
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr11_+_17211912 0.776 ENSMUST00000046955.6
Wdr92
WD repeat domain 92
chr2_+_10372426 0.738 ENSMUST00000114864.2
ENSMUST00000116594.2
ENSMUST00000041105.6
Sfmbt2


Scm-like with four mbt domains 2


chr16_+_20717665 0.725 ENSMUST00000021405.7
Polr2h
polymerase (RNA) II (DNA directed) polypeptide H
chr13_+_23574381 0.715 ENSMUST00000090776.4
Hist1h2ad
histone cluster 1, H2ad
chr17_-_24696147 0.713 ENSMUST00000046839.8
Gfer
growth factor, erv1 (S. cerevisiae)-like (augmenter of liver regeneration)
chr1_-_65186456 0.708 ENSMUST00000169032.1
Idh1
isocitrate dehydrogenase 1 (NADP+), soluble
chrX_-_37191160 0.704 ENSMUST00000016571.7
Ndufa1
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1
chr9_+_38719024 0.695 ENSMUST00000129598.1
Vwa5a
von Willebrand factor A domain containing 5A
chr3_-_28765364 0.688 ENSMUST00000094335.3
Gm6505
predicted pseudogene 6505
chr12_+_59129720 0.684 ENSMUST00000175912.1
ENSMUST00000176892.1
Ctage5

CTAGE family, member 5

chr3_+_90669063 0.682 ENSMUST00000069927.8
S100a8
S100 calcium binding protein A8 (calgranulin A)
chr2_+_152962485 0.674 ENSMUST00000099197.2
ENSMUST00000103155.3
Ttll9

tubulin tyrosine ligase-like family, member 9

chr4_-_129641060 0.630 ENSMUST00000046425.9
ENSMUST00000133803.1
Txlna

taxilin alpha

chr7_+_64392645 0.589 ENSMUST00000037205.8
Mcee
methylmalonyl CoA epimerase
chr19_+_4097392 0.585 ENSMUST00000174514.1
ENSMUST00000174149.1
Cdk2ap2

CDK2-associated protein 2

chr12_+_59129757 0.564 ENSMUST00000069430.8
ENSMUST00000177370.1
Ctage5

CTAGE family, member 5

chr6_+_39592569 0.552 ENSMUST00000135671.1
ENSMUST00000119379.1
Ndufb2

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2

chr14_-_20496780 0.549 ENSMUST00000022353.3
Mss51
MSS51 mitochondrial translational activator
chr9_-_21963568 0.543 ENSMUST00000006397.5
Epor
erythropoietin receptor
chr15_-_77927728 0.541 ENSMUST00000174468.1
ENSMUST00000174529.1
ENSMUST00000173631.1
Txn2


thioredoxin 2


chr14_-_54926784 0.533 ENSMUST00000022813.6
Efs
embryonal Fyn-associated substrate
chr4_-_83285141 0.529 ENSMUST00000150522.1
Ttc39b
tetratricopeptide repeat domain 39B
chr12_-_74316394 0.509 ENSMUST00000110441.1
Gm11042
predicted gene 11042
chr1_-_191907527 0.497 ENSMUST00000069573.5
1700034H15Rik
RIKEN cDNA 1700034H15 gene
chr8_-_84893887 0.478 ENSMUST00000003907.7
ENSMUST00000182458.1
ENSMUST00000109745.1
ENSMUST00000142748.1
Gcdh



glutaryl-Coenzyme A dehydrogenase



chr14_-_59365410 0.461 ENSMUST00000161031.1
ENSMUST00000160425.1
Phf11d

PHD finger protein 11D

chr19_-_43524462 0.449 ENSMUST00000026196.7
Got1
glutamate oxaloacetate transaminase 1, soluble
chr1_+_161969284 0.434 ENSMUST00000160881.1
ENSMUST00000159648.1
Pigc

phosphatidylinositol glycan anchor biosynthesis, class C

chr1_+_88103229 0.408 ENSMUST00000113135.3
ENSMUST00000113138.1
Ugt1a6a
Ugt1a6b
UDP glucuronosyltransferase 1 family, polypeptide A6A
UDP glucuronosyltransferase 1 family, polypeptide A6B
chr9_-_106656081 0.404 ENSMUST00000023959.7
Grm2
glutamate receptor, metabotropic 2
chr7_+_30712209 0.396 ENSMUST00000005692.6
ENSMUST00000170371.1
Atp4a

ATPase, H+/K+ exchanging, gastric, alpha polypeptide

chr13_-_23574196 0.376 ENSMUST00000105106.1
Hist1h2bf
histone cluster 1, H2bf
chr2_-_17731035 0.375 ENSMUST00000028080.5
Nebl
nebulette
chr2_-_130664565 0.371 ENSMUST00000089559.4
Ddrgk1
DDRGK domain containing 1
chr5_+_34989473 0.369 ENSMUST00000114284.1
ENSMUST00000114285.1
Rgs12

regulator of G-protein signaling 12

chr3_-_19265007 0.314 ENSMUST00000091314.4
Pde7a
phosphodiesterase 7A
chr11_-_98438941 0.288 ENSMUST00000002655.7
Mien1
migration and invasion enhancer 1
chr8_+_9977707 0.273 ENSMUST00000139793.1
ENSMUST00000048216.5
Abhd13

abhydrolase domain containing 13

chr14_-_70653081 0.265 ENSMUST00000062629.4
Npm2
nucleophosmin/nucleoplasmin 2
chr2_+_180078623 0.251 ENSMUST00000087563.6
Mtg2
mitochondrial ribosome associated GTPase 2
chr12_-_81532840 0.235 ENSMUST00000166664.1
ENSMUST00000164386.1
ENSMUST00000169158.1
ENSMUST00000164431.1
ENSMUST00000163402.1
Gm20498

Synj2bp


predicted gene 20498

synaptojanin 2 binding protein


chr18_+_61639542 0.217 ENSMUST00000183083.1
ENSMUST00000183087.1
Gm20748

predicted gene, 20748

chr7_+_16309577 0.209 ENSMUST00000002152.6
Bbc3
BCL2 binding component 3
chr12_+_76255209 0.209 ENSMUST00000021443.5
Mthfd1
methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase
chr7_-_28962265 0.188 ENSMUST00000068045.7
Actn4
actinin alpha 4
chr2_-_155592567 0.183 ENSMUST00000155347.1
ENSMUST00000130881.1
ENSMUST00000079691.6
Gss


glutathione synthetase


chr19_-_4793851 0.177 ENSMUST00000178615.1
ENSMUST00000179189.1
ENSMUST00000164376.2
ENSMUST00000164209.2
ENSMUST00000180248.1
Rbm4




RNA binding motif protein 4




chr4_-_134254076 0.172 ENSMUST00000060050.5
Grrp1
glycine/arginine rich protein 1
chr9_-_59486323 0.169 ENSMUST00000165322.1
Arih1
ariadne ubiquitin-conjugating enzyme E2 binding protein homolog 1 (Drosophila)
chr4_-_149099802 0.155 ENSMUST00000103217.4
Pex14
peroxisomal biogenesis factor 14
chr19_+_46328179 0.145 ENSMUST00000026256.2
ENSMUST00000177667.1
Fbxl15

F-box and leucine-rich repeat protein 15

chr3_-_90389884 0.141 ENSMUST00000029541.5
Slc27a3
solute carrier family 27 (fatty acid transporter), member 3
chr11_-_102469839 0.138 ENSMUST00000103086.3
Itga2b
integrin alpha 2b
chr9_-_26999491 0.124 ENSMUST00000060513.7
ENSMUST00000120367.1
Acad8

acyl-Coenzyme A dehydrogenase family, member 8

chr4_-_129640959 0.122 ENSMUST00000132217.1
ENSMUST00000130017.1
ENSMUST00000154105.1
Txlna


taxilin alpha


chr17_+_27685197 0.110 ENSMUST00000097360.2
Pacsin1
protein kinase C and casein kinase substrate in neurons 1
chr18_-_20002093 0.077 ENSMUST00000115848.3
Dsc3
desmocollin 3
chr8_-_91133942 0.068 ENSMUST00000120213.1
ENSMUST00000109609.2
Aktip

thymoma viral proto-oncogene 1 interacting protein

chr2_+_112454997 0.062 ENSMUST00000069747.5
Emc7
ER membrane protein complex subunit 7
chr11_+_58948890 0.046 ENSMUST00000078267.3
Hist3h2ba
histone cluster 3, H2ba
chr19_-_10604258 0.011 ENSMUST00000037678.6
Dak
dihydroxyacetone kinase 2 homolog (yeast)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.7 11.0 GO:0072382 minus-end-directed vesicle transport along microtubule(GO:0072382)
1.9 5.7 GO:0003104 positive regulation of glomerular filtration(GO:0003104) cell communication by chemical coupling(GO:0010643)
1.5 17.6 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
1.1 8.6 GO:0071493 cellular response to UV-B(GO:0071493)
0.9 3.7 GO:0060265 positive regulation of respiratory burst involved in inflammatory response(GO:0060265)
0.8 2.5 GO:0060217 hemangioblast cell differentiation(GO:0060217)
0.8 2.4 GO:0002865 immune response-inhibiting signal transduction(GO:0002765) negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865)
0.7 2.9 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.7 2.7 GO:0046073 dTMP biosynthetic process(GO:0006231) dTMP metabolic process(GO:0046073)
0.6 2.6 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.6 1.8 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.6 2.9 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.5 1.6 GO:1990046 positive regulation of mitochondrial DNA replication(GO:0090297) regulation of cardiolipin metabolic process(GO:1900208) positive regulation of cardiolipin metabolic process(GO:1900210) stress-induced mitochondrial fusion(GO:1990046)
0.5 1.6 GO:0014826 vein smooth muscle contraction(GO:0014826)
0.5 3.0 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.5 2.0 GO:0046294 formaldehyde catabolic process(GO:0046294)
0.5 6.0 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.5 1.5 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
0.4 2.8 GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029)
0.4 1.5 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.4 1.5 GO:0046909 intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445)
0.3 1.4 GO:0042360 vitamin E metabolic process(GO:0042360)
0.3 2.7 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.3 4.2 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.2 0.7 GO:0006097 glyoxylate cycle(GO:0006097)
0.2 2.5 GO:0046512 sphingosine biosynthetic process(GO:0046512) sphingoid biosynthetic process(GO:0046520)
0.2 3.2 GO:0061436 establishment of skin barrier(GO:0061436)
0.2 0.7 GO:0070488 neutrophil aggregation(GO:0070488)
0.2 3.7 GO:0086016 AV node cell action potential(GO:0086016) AV node cell to bundle of His cell signaling(GO:0086027)
0.2 2.0 GO:0006228 UTP biosynthetic process(GO:0006228)
0.2 2.6 GO:0070986 left/right axis specification(GO:0070986)
0.2 4.9 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.2 3.1 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.2 1.8 GO:0002227 innate immune response in mucosa(GO:0002227)
0.2 0.9 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 0.4 GO:0006106 fumarate metabolic process(GO:0006106) aspartate biosynthetic process(GO:0006532) aspartate catabolic process(GO:0006533) alditol biosynthetic process(GO:0019401)
0.1 0.9 GO:0016266 O-glycan processing(GO:0016266)
0.1 3.0 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.1 0.8 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.1 1.3 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.1 7.4 GO:0007019 microtubule depolymerization(GO:0007019)
0.1 3.0 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.1 1.3 GO:1902018 negative regulation of cilium assembly(GO:1902018)
0.1 10.5 GO:0007052 mitotic spindle organization(GO:0007052)
0.1 0.4 GO:0052695 cellular glucuronidation(GO:0052695)
0.1 0.7 GO:0097421 liver regeneration(GO:0097421)
0.1 3.4 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.1 0.9 GO:0006851 mitochondrial calcium ion transport(GO:0006851)
0.1 1.1 GO:0035337 fatty-acyl-CoA metabolic process(GO:0035337)
0.1 0.4 GO:1990564 regulation of I-kappaB phosphorylation(GO:1903719) positive regulation of I-kappaB phosphorylation(GO:1903721) protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.1 1.2 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.1 0.2 GO:0006547 histidine metabolic process(GO:0006547)
0.1 0.2 GO:0016561 protein import into peroxisome matrix, translocation(GO:0016561)
0.0 0.5 GO:0061032 visceral serous pericardium development(GO:0061032)
0.0 0.5 GO:0006662 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.0 0.6 GO:2000035 regulation of stem cell division(GO:2000035)
0.0 1.0 GO:0097062 dendritic spine maintenance(GO:0097062)
0.0 0.2 GO:0097167 circadian regulation of translation(GO:0097167)
0.0 0.9 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 1.4 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 2.0 GO:1902017 regulation of cilium assembly(GO:1902017)
0.0 1.3 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.4 GO:0010155 regulation of proton transport(GO:0010155)
0.0 3.2 GO:0009566 fertilization(GO:0009566)
0.0 2.4 GO:0006342 chromatin silencing(GO:0006342)
0.0 0.2 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.0 0.9 GO:0032611 interleukin-1 beta production(GO:0032611)
0.0 1.7 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.8 GO:0042113 B cell activation(GO:0042113)
0.0 0.4 GO:0014047 glutamate secretion(GO:0014047)
0.0 0.3 GO:0070129 regulation of mitochondrial translation(GO:0070129)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 8.6 GO:0070557 PCNA-p21 complex(GO:0070557)
1.7 10.5 GO:0031262 Ndc80 complex(GO:0031262)
1.6 19.3 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
1.1 4.2 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
0.8 2.5 GO:0033193 Lsd1/2 complex(GO:0033193)
0.6 3.1 GO:0000235 astral microtubule(GO:0000235)
0.6 12.2 GO:0031616 spindle pole centrosome(GO:0031616)
0.5 5.7 GO:0005916 fascia adherens(GO:0005916)
0.4 2.9 GO:0042627 chylomicron(GO:0042627)
0.3 2.6 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.3 1.8 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.2 3.7 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.2 1.3 GO:0045179 apical cortex(GO:0045179)
0.1 8.2 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 6.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 1.6 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540) cytosolic proteasome complex(GO:0031597)
0.1 1.6 GO:0042101 T cell receptor complex(GO:0042101)
0.1 1.4 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 0.9 GO:0046930 pore complex(GO:0046930)
0.1 2.5 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 3.1 GO:0000786 nucleosome(GO:0000786)
0.0 2.8 GO:0005882 intermediate filament(GO:0005882)
0.0 0.7 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.2 GO:1990415 Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429)
0.0 2.0 GO:0005871 kinesin complex(GO:0005871)
0.0 1.5 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.0 3.6 GO:0032993 protein-DNA complex(GO:0032993)
0.0 6.5 GO:0043679 axon terminus(GO:0043679)
0.0 3.0 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 1.3 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 2.3 GO:0005604 basement membrane(GO:0005604)
0.0 2.1 GO:0005643 nuclear pore(GO:0005643)
0.0 0.2 GO:0097413 Lewy body(GO:0097413)
0.0 0.3 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.6 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.7 GO:0016235 aggresome(GO:0016235)
0.0 3.1 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 1.0 GO:0072562 blood microparticle(GO:0072562)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 19.3 GO:0042289 MHC class II protein binding(GO:0042289)
2.9 8.6 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
1.4 5.7 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) gap junction channel activity involved in cell communication by electrical coupling(GO:1903763)
0.8 11.0 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.7 2.0 GO:0018738 S-formylglutathione hydrolase activity(GO:0018738)
0.5 1.6 GO:0004962 endothelin receptor activity(GO:0004962)
0.5 3.1 GO:0008494 translation activator activity(GO:0008494)
0.5 3.7 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.4 3.0 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.4 3.0 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.4 2.5 GO:0017040 ceramidase activity(GO:0017040)
0.4 2.3 GO:0050694 galactose 3-O-sulfotransferase activity(GO:0050694)
0.4 2.7 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.3 1.6 GO:0004920 interleukin-10 receptor activity(GO:0004920)
0.2 2.9 GO:0004806 triglyceride lipase activity(GO:0004806)
0.2 0.7 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.2 1.6 GO:1901612 phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)
0.2 2.0 GO:0043237 laminin-1 binding(GO:0043237)
0.2 3.7 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.2 2.7 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.2 4.2 GO:0000400 four-way junction DNA binding(GO:0000400)
0.2 0.5 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.2 0.7 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.2 0.7 GO:0050544 arachidonic acid binding(GO:0050544)
0.1 0.4 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.1 4.9 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 0.9 GO:0015288 porin activity(GO:0015288)
0.1 1.4 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.1 3.0 GO:0030371 translation repressor activity(GO:0030371)
0.1 3.7 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.1 0.8 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.4 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.1 0.9 GO:0048531 beta-1,3-galactosyltransferase activity(GO:0048531)
0.1 5.2 GO:0003777 microtubule motor activity(GO:0003777)
0.1 0.7 GO:0001055 RNA polymerase II activity(GO:0001055)
0.1 0.2 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.1 2.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 2.5 GO:0070888 E-box binding(GO:0070888)
0.0 0.1 GO:0070051 fibrinogen binding(GO:0070051)
0.0 0.4 GO:0008556 sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556)
0.0 0.2 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 1.4 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 0.1 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.0 0.6 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.0 1.8 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.0 0.4 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 3.2 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 5.1 GO:0001047 core promoter binding(GO:0001047)
0.0 0.6 GO:0016854 racemase and epimerase activity(GO:0016854)
0.0 2.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.2 GO:0035198 miRNA binding(GO:0035198)
0.0 0.2 GO:0016594 glycine binding(GO:0016594)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 8.6 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.4 19.3 NABA_COLLAGENS Genes encoding collagen proteins
0.2 5.7 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 1.9 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 2.0 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.1 3.9 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 4.1 PID_E2F_PATHWAY E2F transcription factor network
0.0 0.7 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.8 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.9 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 2.0 PID_PLK1_PATHWAY PLK1 signaling events
0.0 1.6 PID_ENDOTHELIN_PATHWAY Endothelins
0.0 3.1 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 0.5 PID_EPO_PATHWAY EPO signaling pathway
0.0 0.9 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 5.7 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.4 11.0 REACTOME_KINESINS Genes involved in Kinesins
0.4 19.3 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.3 3.0 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.3 8.6 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.2 2.9 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.2 0.9 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.1 1.4 REACTOME_LIPOPROTEIN_METABOLISM Genes involved in Lipoprotein metabolism
0.1 2.7 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 3.1 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 2.9 REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.1 4.2 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.1 10.4 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 1.5 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.1 2.0 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 3.5 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 3.7 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 0.9 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.1 1.4 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 2.9 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 0.7 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 4.2 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.6 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 1.6 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.4 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 1.6 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.9 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 3.9 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.7 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.9 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 1.3 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 1.1 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.1 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 0.4 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases