Motif ID: Nkx2-1
Z-value: 0.671

Transcription factors associated with Nkx2-1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Nkx2-1 | ENSMUSG00000001496.9 | Nkx2-1 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Nkx2-1 | mm10_v2_chr12_-_56536895_56536937 | 0.52 | 5.7e-04 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.9 | 6.3 | GO:0031536 | positive regulation of exit from mitosis(GO:0031536) |
0.8 | 2.4 | GO:0042320 | regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938) |
0.7 | 1.4 | GO:0009814 | defense response, incompatible interaction(GO:0009814) |
0.7 | 2.6 | GO:0051866 | general adaptation syndrome(GO:0051866) |
0.6 | 1.9 | GO:0042264 | peptidyl-aspartic acid hydroxylation(GO:0042264) |
0.6 | 5.7 | GO:0060179 | male mating behavior(GO:0060179) |
0.5 | 2.3 | GO:1903215 | negative regulation of protein targeting to mitochondrion(GO:1903215) |
0.4 | 3.9 | GO:0047484 | regulation of response to osmotic stress(GO:0047484) cellular response to cholesterol(GO:0071397) |
0.3 | 2.0 | GO:1904587 | response to glycoprotein(GO:1904587) |
0.3 | 5.2 | GO:0097154 | GABAergic neuron differentiation(GO:0097154) |
0.3 | 0.9 | GO:0072034 | renal vesicle induction(GO:0072034) |
0.3 | 1.2 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) |
0.3 | 1.7 | GO:0035469 | determination of pancreatic left/right asymmetry(GO:0035469) |
0.3 | 1.1 | GO:0021502 | neural fold elevation formation(GO:0021502) |
0.3 | 2.6 | GO:0090527 | actin filament reorganization(GO:0090527) |
0.3 | 0.8 | GO:0018199 | peptidyl-glutamine modification(GO:0018199) |
0.3 | 0.8 | GO:1904956 | Wnt signaling pathway involved in somitogenesis(GO:0090244) regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041) |
0.2 | 1.0 | GO:1990481 | mRNA pseudouridine synthesis(GO:1990481) |
0.2 | 3.6 | GO:2000001 | regulation of DNA damage checkpoint(GO:2000001) |
0.2 | 0.6 | GO:0072272 | proximal/distal pattern formation involved in metanephric nephron development(GO:0072272) |
0.2 | 1.2 | GO:0038030 | non-canonical Wnt signaling pathway via MAPK cascade(GO:0038030) non-canonical Wnt signaling pathway via JNK cascade(GO:0038031) |
0.1 | 1.3 | GO:0032306 | regulation of prostaglandin secretion(GO:0032306) |
0.1 | 1.3 | GO:0035520 | monoubiquitinated protein deubiquitination(GO:0035520) |
0.1 | 0.5 | GO:0072592 | oxygen metabolic process(GO:0072592) |
0.1 | 0.5 | GO:0002339 | B cell selection(GO:0002339) |
0.1 | 0.4 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
0.1 | 0.3 | GO:0046013 | T cell homeostatic proliferation(GO:0001777) regulation of T cell homeostatic proliferation(GO:0046013) negative regulation of T-helper 17 type immune response(GO:2000317) regulation of T-helper 17 cell differentiation(GO:2000319) negative regulation of T-helper 17 cell differentiation(GO:2000320) |
0.1 | 1.5 | GO:0032060 | bleb assembly(GO:0032060) |
0.1 | 0.7 | GO:0010571 | positive regulation of nuclear cell cycle DNA replication(GO:0010571) |
0.1 | 0.9 | GO:0006337 | nucleosome disassembly(GO:0006337) |
0.1 | 0.4 | GO:0016584 | nucleosome positioning(GO:0016584) |
0.1 | 0.2 | GO:0034392 | negative regulation of smooth muscle cell apoptotic process(GO:0034392) |
0.1 | 0.3 | GO:0035878 | nail development(GO:0035878) |
0.0 | 0.5 | GO:2000381 | negative regulation of mesoderm development(GO:2000381) |
0.0 | 2.8 | GO:2000179 | positive regulation of neural precursor cell proliferation(GO:2000179) |
0.0 | 0.3 | GO:0070601 | centromeric sister chromatid cohesion(GO:0070601) |
0.0 | 0.6 | GO:0032515 | negative regulation of phosphoprotein phosphatase activity(GO:0032515) |
0.0 | 0.6 | GO:0003334 | keratinocyte development(GO:0003334) |
0.0 | 0.9 | GO:0045736 | negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030) |
0.0 | 0.5 | GO:2000042 | negative regulation of double-strand break repair via homologous recombination(GO:2000042) |
0.0 | 0.4 | GO:0032287 | peripheral nervous system myelin maintenance(GO:0032287) |
0.0 | 1.4 | GO:0016126 | sterol biosynthetic process(GO:0016126) |
0.0 | 1.6 | GO:0042632 | cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092) |
0.0 | 0.4 | GO:0035721 | intraciliary retrograde transport(GO:0035721) |
0.0 | 0.3 | GO:0043248 | proteasome assembly(GO:0043248) |
0.0 | 0.2 | GO:0061635 | regulation of protein complex stability(GO:0061635) |
0.0 | 0.3 | GO:0090141 | positive regulation of mitochondrial fission(GO:0090141) |
0.0 | 0.4 | GO:2000300 | regulation of synaptic vesicle exocytosis(GO:2000300) |
0.0 | 0.2 | GO:0006999 | nuclear pore organization(GO:0006999) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.3 | 6.3 | GO:0032133 | interphase microtubule organizing center(GO:0031021) chromosome passenger complex(GO:0032133) |
0.3 | 1.9 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
0.2 | 3.5 | GO:0031616 | spindle pole centrosome(GO:0031616) |
0.1 | 1.1 | GO:0002177 | manchette(GO:0002177) |
0.1 | 1.3 | GO:0044233 | ER-mitochondrion membrane contact site(GO:0044233) |
0.1 | 1.6 | GO:0005652 | nuclear lamina(GO:0005652) |
0.1 | 0.4 | GO:0042719 | mitochondrial intermembrane space protein transporter complex(GO:0042719) |
0.1 | 1.2 | GO:0097539 | ciliary transition fiber(GO:0097539) |
0.1 | 0.5 | GO:0042613 | MHC class II protein complex(GO:0042613) |
0.0 | 0.4 | GO:0035749 | myelin sheath adaxonal region(GO:0035749) |
0.0 | 0.6 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
0.0 | 0.9 | GO:0071564 | npBAF complex(GO:0071564) |
0.0 | 0.4 | GO:0030991 | intraciliary transport particle A(GO:0030991) |
0.0 | 0.3 | GO:0031415 | NatA complex(GO:0031415) |
0.0 | 3.9 | GO:0005901 | caveola(GO:0005901) |
0.0 | 0.3 | GO:0030056 | hemidesmosome(GO:0030056) |
0.0 | 0.3 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
0.0 | 0.4 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
0.0 | 1.6 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
0.0 | 2.6 | GO:0005884 | actin filament(GO:0005884) |
0.0 | 4.9 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
0.0 | 0.1 | GO:0036195 | muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195) |
0.0 | 0.1 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
0.0 | 2.8 | GO:0045121 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
0.0 | 0.1 | GO:0089701 | U2AF(GO:0089701) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 2.6 | GO:0008889 | glycerophosphodiester phosphodiesterase activity(GO:0008889) |
0.3 | 2.8 | GO:0008474 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
0.2 | 1.2 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
0.2 | 0.2 | GO:0031762 | alpha-1A adrenergic receptor binding(GO:0031691) alpha-1B adrenergic receptor binding(GO:0031692) follicle-stimulating hormone receptor binding(GO:0031762) |
0.2 | 0.8 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
0.2 | 1.4 | GO:0070087 | chromo shadow domain binding(GO:0070087) |
0.2 | 2.0 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
0.2 | 1.1 | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity(GO:0004726) |
0.1 | 6.3 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
0.1 | 2.4 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
0.1 | 4.6 | GO:0005109 | frizzled binding(GO:0005109) |
0.1 | 1.3 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
0.1 | 1.1 | GO:0070700 | BMP receptor binding(GO:0070700) |
0.1 | 0.5 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
0.1 | 0.6 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
0.1 | 2.7 | GO:0005272 | sodium channel activity(GO:0005272) |
0.1 | 2.6 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
0.1 | 1.2 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
0.1 | 0.9 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
0.1 | 0.3 | GO:0005134 | interleukin-2 receptor binding(GO:0005134) |
0.1 | 0.3 | GO:0038132 | neuregulin binding(GO:0038132) |
0.1 | 0.4 | GO:0061649 | ubiquitinated histone binding(GO:0061649) |
0.1 | 1.0 | GO:0009982 | pseudouridine synthase activity(GO:0009982) |
0.0 | 0.5 | GO:1990405 | protein antigen binding(GO:1990405) |
0.0 | 1.1 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
0.0 | 3.9 | GO:0008565 | protein transporter activity(GO:0008565) |
0.0 | 1.9 | GO:0016706 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706) |
0.0 | 0.9 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
0.0 | 1.4 | GO:0042054 | histone methyltransferase activity(GO:0042054) |
0.0 | 0.3 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
0.0 | 1.4 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
0.0 | 3.5 | GO:0004721 | phosphoprotein phosphatase activity(GO:0004721) |
0.0 | 0.1 | GO:0010861 | thyroid hormone receptor activator activity(GO:0010861) |
0.0 | 0.2 | GO:0031702 | angiotensin receptor binding(GO:0031701) type 1 angiotensin receptor binding(GO:0031702) |
0.0 | 5.9 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
0.0 | 4.6 | GO:0045296 | cadherin binding(GO:0045296) |
0.0 | 0.2 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 9.8 | PID_AURORA_A_PATHWAY | Aurora A signaling |
0.0 | 1.8 | PID_ARF6_PATHWAY | Arf6 signaling events |
0.0 | 1.1 | PID_EPHA2_FWD_PATHWAY | EPHA2 forward signaling |
0.0 | 1.2 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
0.0 | 1.8 | PID_A6B1_A6B4_INTEGRIN_PATHWAY | a6b1 and a6b4 Integrin signaling |
0.0 | 0.8 | PID_INTEGRIN_A9B1_PATHWAY | Alpha9 beta1 integrin signaling events |
0.0 | 5.5 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
0.0 | 1.4 | PID_FANCONI_PATHWAY | Fanconi anemia pathway |
0.0 | 0.7 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
0.0 | 1.0 | PID_E2F_PATHWAY | E2F transcription factor network |
0.0 | 0.9 | PID_REG_GR_PATHWAY | Glucocorticoid receptor regulatory network |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.7 | 2.0 | REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS | Genes involved in Hormone ligand-binding receptors |
0.1 | 1.4 | REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY | Genes involved in Regulation of the Fanconi anemia pathway |
0.1 | 5.3 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
0.1 | 1.4 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
0.1 | 6.3 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
0.0 | 1.3 | REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
0.0 | 2.6 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
0.0 | 0.7 | REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
0.0 | 0.4 | REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
0.0 | 0.9 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
0.0 | 2.4 | REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS | Genes involved in G alpha (q) signalling events |
0.0 | 0.2 | REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS | Genes involved in Thrombin signalling through proteinase activated receptors (PARs) |
0.0 | 0.5 | REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
0.0 | 0.3 | REACTOME_IL_RECEPTOR_SHC_SIGNALING | Genes involved in Interleukin receptor SHC signaling |
0.0 | 0.9 | REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
0.0 | 0.4 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
0.0 | 0.5 | REACTOME_RECYCLING_PATHWAY_OF_L1 | Genes involved in Recycling pathway of L1 |