Motif ID: Vsx1_Uncx_Prrx2_Shox2_Noto

Z-value: 1.030


Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Uncxmm10_v2_chr5_+_139543889_1395439040.688.7e-07Click!
Prrx2mm10_v2_chr2_+_30845059_308450590.434.6e-03Click!
Shox2mm10_v2_chr3_-_66981279_669813180.163.1e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Vsx1_Uncx_Prrx2_Shox2_Noto

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_139543889 24.738 ENSMUST00000174792.1
ENSMUST00000031523.8
Uncx

UNC homeobox

chr2_+_20737306 20.047 ENSMUST00000114606.1
ENSMUST00000114608.1
Etl4

enhancer trap locus 4

chr14_-_48665098 16.360 ENSMUST00000118578.1
Otx2
orthodenticle homolog 2 (Drosophila)
chr3_+_159839729 14.508 ENSMUST00000068952.5
Wls
wntless homolog (Drosophila)
chr8_-_61902669 13.066 ENSMUST00000121785.1
ENSMUST00000034057.7
Palld

palladin, cytoskeletal associated protein

chr3_+_55782500 12.073 ENSMUST00000075422.4
Mab21l1
mab-21-like 1 (C. elegans)
chr2_+_71528657 11.382 ENSMUST00000126400.1
Dlx1
distal-less homeobox 1
chr17_+_34592248 11.293 ENSMUST00000038149.6
Pbx2
pre B cell leukemia homeobox 2
chr3_+_125404292 11.139 ENSMUST00000144344.1
Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chrX_-_60893430 11.134 ENSMUST00000135107.2
Sox3
SRY-box containing gene 3
chr3_+_125404072 11.118 ENSMUST00000173932.1
Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr2_-_168767136 10.848 ENSMUST00000029061.5
ENSMUST00000103074.1
Sall4

sal-like 4 (Drosophila)

chr7_-_49636847 10.529 ENSMUST00000032717.6
Dbx1
developing brain homeobox 1
chr14_-_118052235 9.908 ENSMUST00000022725.2
Dct
dopachrome tautomerase
chr2_-_168767029 9.827 ENSMUST00000075044.3
Sall4
sal-like 4 (Drosophila)
chr6_-_147264124 8.822 ENSMUST00000052296.6
Pthlh
parathyroid hormone-like peptide
chr2_+_25372315 8.682 ENSMUST00000028329.6
ENSMUST00000114293.2
ENSMUST00000100323.2
Sapcd2


suppressor APC domain containing 2


chr2_-_72986716 8.126 ENSMUST00000112062.1
Gm11084
predicted gene 11084
chr12_+_38780817 7.977 ENSMUST00000160856.1
Etv1
ets variant gene 1
chr12_+_38780284 7.946 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
Etv1


ets variant gene 1


chr6_+_8948608 7.902 ENSMUST00000160300.1
Nxph1
neurexophilin 1
chr13_-_102906046 7.796 ENSMUST00000171791.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr4_-_97778042 7.770 ENSMUST00000146447.1
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr10_-_45470201 7.578 ENSMUST00000079390.6
Lin28b
lin-28 homolog B (C. elegans)
chr4_-_35845204 7.411 ENSMUST00000164772.1
ENSMUST00000065173.2
Lingo2

leucine rich repeat and Ig domain containing 2

chr13_-_102905740 7.227 ENSMUST00000167462.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr3_-_88410295 6.886 ENSMUST00000056370.7
Pmf1
polyamine-modulated factor 1
chr12_+_38783503 6.321 ENSMUST00000159334.1
Etv1
ets variant gene 1
chr3_-_79841729 6.087 ENSMUST00000168038.1
Tmem144
transmembrane protein 144
chr3_+_134236483 5.814 ENSMUST00000181904.1
ENSMUST00000053048.9
Cxxc4

CXXC finger 4

chr13_-_53473074 5.768 ENSMUST00000021922.8
Msx2
msh homeobox 2
chr16_-_26989974 5.744 ENSMUST00000089832.4
Gmnc
geminin coiled-coil domain containing
chr4_-_58499398 5.491 ENSMUST00000107570.1
Lpar1
lysophosphatidic acid receptor 1
chr12_+_38781093 5.015 ENSMUST00000161513.1
Etv1
ets variant gene 1
chr9_+_119063429 5.013 ENSMUST00000141185.1
ENSMUST00000126251.1
ENSMUST00000136561.1
Vill


villin-like


chr7_-_116198487 4.610 ENSMUST00000181981.1
Plekha7
pleckstrin homology domain containing, family A member 7
chr3_-_17786834 4.474 ENSMUST00000099198.2
Gm10742
predicted gene 10742
chr3_-_86548268 4.416 ENSMUST00000077524.3
Mab21l2
mab-21-like 2 (C. elegans)
chr3_-_116253467 4.328 ENSMUST00000090473.5
Gpr88
G-protein coupled receptor 88
chr7_+_144838590 4.190 ENSMUST00000105898.1
Fgf3
fibroblast growth factor 3
chr9_+_118478344 3.996 ENSMUST00000035020.8
Eomes
eomesodermin homolog (Xenopus laevis)
chrM_+_7005 3.883 ENSMUST00000082405.1
mt-Co2
mitochondrially encoded cytochrome c oxidase II
chr12_+_38783455 3.833 ENSMUST00000161980.1
ENSMUST00000160701.1
Etv1

ets variant gene 1

chr1_+_109983737 3.781 ENSMUST00000172005.1
Cdh7
cadherin 7, type 2
chr7_-_66427469 3.766 ENSMUST00000015278.7
Aldh1a3
aldehyde dehydrogenase family 1, subfamily A3
chr13_+_23575753 3.739 ENSMUST00000105105.1
Hist1h3d
histone cluster 1, H3d
chr13_-_114458720 3.645 ENSMUST00000022287.5
Fst
follistatin
chr4_-_14621669 3.565 ENSMUST00000143105.1
Slc26a7
solute carrier family 26, member 7
chr17_+_17402672 3.525 ENSMUST00000115576.2
Lix1
limb expression 1 homolog (chicken)
chr19_+_59458372 3.467 ENSMUST00000062216.3
Emx2
empty spiracles homeobox 2
chr3_-_154328634 3.319 ENSMUST00000167744.1
Lhx8
LIM homeobox protein 8
chr13_-_78196373 3.271 ENSMUST00000125176.2
Nr2f1
nuclear receptor subfamily 2, group F, member 1
chr2_-_28916412 3.257 ENSMUST00000050776.2
ENSMUST00000113849.1
Barhl1

BarH-like 1 (Drosophila)

chr5_+_115235836 3.149 ENSMUST00000081497.6
Pop5
processing of precursor 5, ribonuclease P/MRP family (S. cerevisiae)
chr1_-_78968079 2.877 ENSMUST00000049117.5
Gm5830
predicted pseudogene 5830
chr5_-_77115145 2.782 ENSMUST00000081964.5
Hopx
HOP homeobox
chr4_+_154960915 2.671 ENSMUST00000049621.6
Hes5
hairy and enhancer of split 5 (Drosophila)
chr6_-_124779686 2.647 ENSMUST00000147669.1
ENSMUST00000128697.1
ENSMUST00000032218.3
ENSMUST00000112475.2
Lrrc23



leucine rich repeat containing 23



chr4_-_110292719 2.628 ENSMUST00000106601.1
Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr11_+_102604370 2.561 ENSMUST00000057893.5
Fzd2
frizzled homolog 2 (Drosophila)
chr12_-_40037387 2.537 ENSMUST00000146905.1
Arl4a
ADP-ribosylation factor-like 4A
chr3_+_122419772 2.495 ENSMUST00000029766.4
Bcar3
breast cancer anti-estrogen resistance 3
chr7_-_115824699 2.483 ENSMUST00000169129.1
Sox6
SRY-box containing gene 6
chr2_-_28916668 2.483 ENSMUST00000113847.1
Barhl1
BarH-like 1 (Drosophila)
chr6_+_7555053 2.459 ENSMUST00000090679.2
ENSMUST00000184986.1
Tac1

tachykinin 1

chr8_+_45658666 2.446 ENSMUST00000134675.1
ENSMUST00000139869.1
ENSMUST00000126067.1
Sorbs2


sorbin and SH3 domain containing 2


chr9_+_106368594 2.445 ENSMUST00000172306.2
Dusp7
dual specificity phosphatase 7
chr18_+_4993795 2.384 ENSMUST00000153016.1
Svil
supervillin
chr10_+_26772477 2.355 ENSMUST00000039557.7
Arhgap18
Rho GTPase activating protein 18
chr8_+_45658731 2.334 ENSMUST00000143820.1
ENSMUST00000132139.1
Sorbs2

sorbin and SH3 domain containing 2

chr19_-_59170978 2.310 ENSMUST00000172821.2
Vax1
ventral anterior homeobox containing gene 1
chr1_+_110099295 2.271 ENSMUST00000134301.1
Cdh7
cadherin 7, type 2
chr11_+_60537978 2.269 ENSMUST00000044250.3
Alkbh5
alkB, alkylation repair homolog 5 (E. coli)
chr13_+_8202885 2.192 ENSMUST00000139438.1
ENSMUST00000135574.1
Adarb2

adenosine deaminase, RNA-specific, B2

chr3_+_67892189 2.184 ENSMUST00000063263.3
Iqcj
IQ motif containing J
chr4_-_14621494 2.177 ENSMUST00000149633.1
Slc26a7
solute carrier family 26, member 7
chr5_+_15516489 2.059 ENSMUST00000178227.1
Gm21847
predicted gene, 21847
chr7_-_45830776 2.051 ENSMUST00000107723.2
ENSMUST00000131384.1
Grwd1

glutamate-rich WD repeat containing 1

chr7_-_5014645 2.050 ENSMUST00000165320.1
Fiz1
Flt3 interacting zinc finger protein 1
chr4_+_136143497 1.998 ENSMUST00000008016.2
Id3
inhibitor of DNA binding 3
chr19_+_24875679 1.964 ENSMUST00000073080.5
Gm10053
predicted gene 10053
chr6_+_15196949 1.963 ENSMUST00000151301.1
ENSMUST00000131414.1
ENSMUST00000140557.1
ENSMUST00000115469.1
Foxp2



forkhead box P2



chr2_-_58052832 1.959 ENSMUST00000090940.5
Ermn
ermin, ERM-like protein
chr1_+_153665666 1.957 ENSMUST00000111814.1
ENSMUST00000111810.1
Rgs8

regulator of G-protein signaling 8

chr3_-_100489324 1.921 ENSMUST00000061455.8
Fam46c
family with sequence similarity 46, member C
chr8_-_84662841 1.889 ENSMUST00000060427.4
Ier2
immediate early response 2
chr2_+_9882622 1.870 ENSMUST00000114919.1
4930412O13Rik
RIKEN cDNA 4930412O13 gene
chr1_+_153665274 1.869 ENSMUST00000152114.1
ENSMUST00000111812.1
Rgs8

regulator of G-protein signaling 8

chr1_-_172027269 1.844 ENSMUST00000027837.6
ENSMUST00000111264.1
Vangl2

vang-like 2 (van gogh, Drosophila)

chr9_-_71163224 1.819 ENSMUST00000074465.2
Aqp9
aquaporin 9
chr10_+_88091070 1.813 ENSMUST00000048621.7
Pmch
pro-melanin-concentrating hormone
chr18_+_56432116 1.780 ENSMUST00000070166.5
Gramd3
GRAM domain containing 3
chr2_+_61804453 1.718 ENSMUST00000048934.8
Tbr1
T-box brain gene 1
chr4_-_14621805 1.716 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chr15_-_79285502 1.714 ENSMUST00000165408.1
Baiap2l2
BAI1-associated protein 2-like 2
chr14_+_79515618 1.683 ENSMUST00000110835.1
Elf1
E74-like factor 1
chr4_+_13751297 1.627 ENSMUST00000105566.2
Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr3_+_122044428 1.618 ENSMUST00000013995.8
Abca4
ATP-binding cassette, sub-family A (ABC1), member 4
chrM_+_2743 1.576 ENSMUST00000082392.1
mt-Nd1
mitochondrially encoded NADH dehydrogenase 1
chr14_-_48667508 1.531 ENSMUST00000144465.1
ENSMUST00000133479.1
ENSMUST00000119070.1
ENSMUST00000152018.1
Otx2



orthodenticle homolog 2 (Drosophila)



chr7_+_125829653 1.525 ENSMUST00000124223.1
D430042O09Rik
RIKEN cDNA D430042O09 gene
chr18_-_80986578 1.525 ENSMUST00000057950.7
Sall3
sal-like 3 (Drosophila)
chr9_+_35423582 1.511 ENSMUST00000154652.1
Cdon
cell adhesion molecule-related/down-regulated by oncogenes
chr10_+_73821857 1.509 ENSMUST00000177128.1
ENSMUST00000064562.7
ENSMUST00000129404.2
ENSMUST00000105426.3
ENSMUST00000131321.2
ENSMUST00000126920.2
ENSMUST00000147189.2
ENSMUST00000105424.3
ENSMUST00000092420.6
ENSMUST00000105429.3
ENSMUST00000131724.2
ENSMUST00000152655.2
ENSMUST00000151116.2
ENSMUST00000155701.2
ENSMUST00000152819.2
ENSMUST00000125517.2
ENSMUST00000124046.1
ENSMUST00000149977.2
ENSMUST00000146682.1
ENSMUST00000177107.1
Pcdh15



















protocadherin 15



















chr12_+_109545390 1.506 ENSMUST00000146701.1
Meg3
maternally expressed 3
chr8_-_45382198 1.501 ENSMUST00000093526.6
Fam149a
family with sequence similarity 149, member A
chrX_+_9885622 1.494 ENSMUST00000067529.2
ENSMUST00000086165.3
Sytl5

synaptotagmin-like 5

chr9_+_72806874 1.487 ENSMUST00000055535.8
Prtg
protogenin homolog (Gallus gallus)
chr15_-_9140374 1.468 ENSMUST00000096482.3
ENSMUST00000110585.2
Skp2

S-phase kinase-associated protein 2 (p45)

chr2_-_30093642 1.463 ENSMUST00000102865.4
Zdhhc12
zinc finger, DHHC domain containing 12
chr3_-_157925056 1.451 ENSMUST00000118539.1
Cth
cystathionase (cystathionine gamma-lyase)
chr19_-_15924560 1.438 ENSMUST00000162053.1
Psat1
phosphoserine aminotransferase 1
chr5_+_138187485 1.437 ENSMUST00000110934.2
Cnpy4
canopy 4 homolog (zebrafish)
chr2_+_52038005 1.418 ENSMUST00000065927.5
Tnfaip6
tumor necrosis factor alpha induced protein 6
chr1_+_10993452 1.416 ENSMUST00000027056.5
Prex2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr1_+_153665627 1.415 ENSMUST00000147482.1
Rgs8
regulator of G-protein signaling 8
chr1_+_153665587 1.415 ENSMUST00000147700.1
Rgs8
regulator of G-protein signaling 8
chr17_-_35697971 1.411 ENSMUST00000146472.1
Ddr1
discoidin domain receptor family, member 1
chr2_-_33718789 1.400 ENSMUST00000130532.1
9430024E24Rik
RIKEN cDNA 9430024E24 gene
chr6_+_79818031 1.381 ENSMUST00000179797.1
Gm20594
predicted gene, 20594
chr11_+_98798653 1.330 ENSMUST00000037930.6
Msl1
male-specific lethal 1 homolog (Drosophila)
chr4_+_62583568 1.329 ENSMUST00000098031.3
Rgs3
regulator of G-protein signaling 3
chr13_+_89540636 1.323 ENSMUST00000022108.7
Hapln1
hyaluronan and proteoglycan link protein 1
chr10_+_102158858 1.319 ENSMUST00000138522.1
ENSMUST00000163753.1
ENSMUST00000138016.1
Mgat4c


mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)


chr11_-_50292302 1.315 ENSMUST00000059458.4
Maml1
mastermind like 1 (Drosophila)
chrX_-_102157065 1.296 ENSMUST00000056904.2
Ercc6l
excision repair cross-complementing rodent repair deficiency complementation group 6 like
chr2_+_38341068 1.291 ENSMUST00000133661.1
Lhx2
LIM homeobox protein 2
chr7_+_28881656 1.280 ENSMUST00000066880.4
Capn12
calpain 12
chr10_+_128747850 1.270 ENSMUST00000163377.2
Wibg
within bgcn homolog (Drosophila)
chr6_+_29859374 1.269 ENSMUST00000115238.3
Ahcyl2
S-adenosylhomocysteine hydrolase-like 2
chr2_+_71389239 1.266 ENSMUST00000028408.2
Hat1
histone aminotransferase 1
chr10_+_37139558 1.263 ENSMUST00000062667.3
5930403N24Rik
RIKEN cDNA 5930403N24 gene
chr10_-_53647080 1.235 ENSMUST00000169866.1
Fam184a
family with sequence similarity 184, member A
chr14_-_46390501 1.229 ENSMUST00000100676.2
Bmp4
bone morphogenetic protein 4
chr4_-_4138432 1.205 ENSMUST00000070375.7
Penk
preproenkephalin
chr11_-_31671863 1.200 ENSMUST00000058060.7
Bod1
biorientation of chromosomes in cell division 1
chr2_-_30093607 1.195 ENSMUST00000081838.6
Zdhhc12
zinc finger, DHHC domain containing 12
chr9_+_65890237 1.181 ENSMUST00000045802.6
2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr11_+_52098681 1.179 ENSMUST00000020608.2
Ppp2ca
protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
chr5_-_87482258 1.135 ENSMUST00000079811.6
ENSMUST00000144144.1
Ugt2a1

UDP glucuronosyltransferase 2 family, polypeptide A1

chr5_-_138187177 1.133 ENSMUST00000110937.1
ENSMUST00000139276.1
ENSMUST00000048698.7
ENSMUST00000123415.1
Taf6



TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor



chr3_+_121291725 1.115 ENSMUST00000039442.7
Alg14
asparagine-linked glycosylation 14
chr11_+_94327984 1.108 ENSMUST00000107818.2
ENSMUST00000051221.6
Ankrd40

ankyrin repeat domain 40

chr12_-_57546121 1.106 ENSMUST00000044380.6
Foxa1
forkhead box A1
chr10_+_85386813 1.093 ENSMUST00000105307.1
ENSMUST00000020231.3
Btbd11

BTB (POZ) domain containing 11

chrX_-_134111852 1.088 ENSMUST00000033610.6
Nox1
NADPH oxidase 1
chr1_+_137928100 1.067 ENSMUST00000054333.2
A130050O07Rik
RIKEN cDNA A130050O07 gene
chr6_+_134929118 1.066 ENSMUST00000185152.1
ENSMUST00000184504.1
RP23-45G16.5

RP23-45G16.5

chr3_-_141982224 1.050 ENSMUST00000029948.8
Bmpr1b
bone morphogenetic protein receptor, type 1B
chr14_+_73237891 1.039 ENSMUST00000044405.6
Lpar6
lysophosphatidic acid receptor 6
chr14_-_12345847 1.031 ENSMUST00000022262.4
Fezf2
Fez family zinc finger 2
chr12_+_3954943 0.997 ENSMUST00000020990.5
Pomc
pro-opiomelanocortin-alpha
chr9_-_96437434 0.975 ENSMUST00000070500.2
BC043934
cDNA sequence BC043934
chr17_+_12119274 0.964 ENSMUST00000024594.2
Agpat4
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
chr2_+_83724397 0.945 ENSMUST00000028499.4
ENSMUST00000141725.1
ENSMUST00000111740.2
Itgav


integrin alpha V


chr9_+_45138437 0.941 ENSMUST00000060125.5
Scn4b
sodium channel, type IV, beta
chr6_-_99266494 0.940 ENSMUST00000113326.2
Foxp1
forkhead box P1
chr17_-_48432723 0.935 ENSMUST00000046549.3
Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr2_+_132847719 0.934 ENSMUST00000124836.1
ENSMUST00000154160.1
Crls1

cardiolipin synthase 1

chr7_-_37773555 0.926 ENSMUST00000176534.1
Zfp536
zinc finger protein 536
chr4_+_5724304 0.919 ENSMUST00000108380.1
Fam110b
family with sequence similarity 110, member B
chr10_+_128337761 0.896 ENSMUST00000005826.7
Cs
citrate synthase
chr3_+_133338936 0.878 ENSMUST00000150386.1
ENSMUST00000125858.1
Ppa2

pyrophosphatase (inorganic) 2

chr3_+_32515295 0.877 ENSMUST00000029203.7
Zfp639
zinc finger protein 639
chr1_-_172027251 0.870 ENSMUST00000138714.1
Vangl2
vang-like 2 (van gogh, Drosophila)
chr1_-_72284248 0.857 ENSMUST00000097698.4
ENSMUST00000027381.6
Pecr

peroxisomal trans-2-enoyl-CoA reductase

chr10_+_94575257 0.848 ENSMUST00000121471.1
Tmcc3
transmembrane and coiled coil domains 3
chr18_+_4920509 0.822 ENSMUST00000126977.1
Svil
supervillin
chr13_-_58354862 0.801 ENSMUST00000043605.5
Kif27
kinesin family member 27
chr2_+_3114220 0.783 ENSMUST00000072955.5
Fam171a1
family with sequence similarity 171, member A1
chr2_+_109917639 0.778 ENSMUST00000046548.7
ENSMUST00000111037.2
Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr1_+_74284930 0.776 ENSMUST00000113805.1
ENSMUST00000027370.6
ENSMUST00000087226.4
Pnkd


paroxysmal nonkinesiogenic dyskinesia


chr7_+_101896340 0.753 ENSMUST00000035395.7
ENSMUST00000106973.1
ENSMUST00000144207.1
Anapc15


anaphase prompoting complex C subunit 15


chr1_+_87183310 0.747 ENSMUST00000044533.8
Prss56
protease, serine 56
chr5_+_135106881 0.747 ENSMUST00000005507.3
Mlxipl
MLX interacting protein-like
chrM_+_9452 0.746 ENSMUST00000082411.1
mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chr14_-_46390576 0.742 ENSMUST00000074077.5
Bmp4
bone morphogenetic protein 4
chr2_+_181767040 0.723 ENSMUST00000108756.1
Myt1
myelin transcription factor 1
chr17_+_34039437 0.723 ENSMUST00000131134.1
ENSMUST00000087497.4
ENSMUST00000114255.1
ENSMUST00000114252.1
Col11a2



collagen, type XI, alpha 2



chr4_+_8690399 0.719 ENSMUST00000127476.1
Chd7
chromodomain helicase DNA binding protein 7
chr15_-_102350692 0.714 ENSMUST00000041208.7
Aaas
achalasia, adrenocortical insufficiency, alacrimia
chr15_-_34495180 0.710 ENSMUST00000022946.5
Hrsp12
heat-responsive protein 12
chr2_-_174346712 0.701 ENSMUST00000168292.1
Gm20721
predicted gene, 20721
chr18_+_34758890 0.690 ENSMUST00000049281.5
Fam53c
family with sequence similarity 53, member C
chr2_+_181767283 0.682 ENSMUST00000108757.2
Myt1
myelin transcription factor 1
chr8_+_45627709 0.679 ENSMUST00000134321.1
ENSMUST00000135336.1
Sorbs2

sorbin and SH3 domain containing 2

chr2_+_80638798 0.677 ENSMUST00000028382.6
ENSMUST00000124377.1
Nup35

nucleoporin 35

chr15_-_13173607 0.676 ENSMUST00000036439.4
Cdh6
cadherin 6
chrX_+_150589907 0.666 ENSMUST00000080884.4
Pfkfb1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr18_-_56975333 0.618 ENSMUST00000139243.2
ENSMUST00000025488.8
C330018D20Rik

RIKEN cDNA C330018D20 gene

chr9_+_118478182 0.608 ENSMUST00000111763.1
Eomes
eomesodermin homolog (Xenopus laevis)
chrX_-_74246534 0.599 ENSMUST00000101454.2
ENSMUST00000033699.6
Flna

filamin, alpha

chr18_-_66022580 0.598 ENSMUST00000143990.1
Lman1
lectin, mannose-binding, 1
chr15_-_64922290 0.596 ENSMUST00000023007.5
Adcy8
adenylate cyclase 8
chrX_+_159303266 0.591 ENSMUST00000112491.1
Rps6ka3
ribosomal protein S6 kinase polypeptide 3
chr4_-_132510493 0.587 ENSMUST00000030724.8
Sesn2
sestrin 2
chr10_-_80421847 0.577 ENSMUST00000156244.1
Tcf3
transcription factor 3
chr4_-_42168603 0.569 ENSMUST00000098121.3
Gm13305
predicted gene 13305
chr11_-_3931789 0.568 ENSMUST00000109992.1
ENSMUST00000109988.1
Tcn2

transcobalamin 2

chr7_+_49910112 0.556 ENSMUST00000056442.5
Slc6a5
solute carrier family 6 (neurotransmitter transporter, glycine), member 5

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.8 14.5 GO:0061357 Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) positive regulation of Wnt protein secretion(GO:0061357)
4.5 17.9 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
3.8 11.4 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
3.1 24.7 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
2.8 31.1 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
1.9 5.8 GO:0035880 embryonic nail plate morphogenesis(GO:0035880) positive regulation of catagen(GO:0051795) frontal suture morphogenesis(GO:0060364)
1.7 9.9 GO:0006570 tyrosine metabolic process(GO:0006570)
1.5 4.6 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
1.4 4.2 GO:0030916 otic vesicle formation(GO:0030916)
1.4 5.5 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
1.3 1.3 GO:0003162 atrioventricular node development(GO:0003162)
1.3 3.8 GO:0060166 olfactory pit development(GO:0060166)
1.3 7.5 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
1.2 4.6 GO:0061743 motor learning(GO:0061743)
1.2 3.5 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
1.1 20.7 GO:0001833 inner cell mass cell proliferation(GO:0001833)
1.1 7.5 GO:0019532 oxalate transport(GO:0019532)
0.9 7.2 GO:0003150 muscular septum morphogenesis(GO:0003150)
0.8 7.6 GO:0010587 miRNA catabolic process(GO:0010587)
0.8 4.6 GO:0045218 zonula adherens maintenance(GO:0045218)
0.7 13.1 GO:0071803 keratinocyte development(GO:0003334) positive regulation of podosome assembly(GO:0071803)
0.7 5.4 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.7 2.7 GO:2000974 comma-shaped body morphogenesis(GO:0072049) negative regulation of pro-B cell differentiation(GO:2000974)
0.7 10.5 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.6 3.6 GO:0051798 positive regulation of hair follicle development(GO:0051798)
0.6 1.8 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.6 2.3 GO:0035553 oxidative single-stranded RNA demethylation(GO:0035553)
0.6 11.1 GO:0007530 sex determination(GO:0007530)
0.5 6.7 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213) regulation of dopamine receptor signaling pathway(GO:0060159)
0.5 6.1 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.5 2.8 GO:0043415 positive regulation of skeletal muscle tissue regeneration(GO:0043415)
0.4 1.7 GO:0001661 conditioned taste aversion(GO:0001661)
0.4 2.5 GO:0021780 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.4 3.1 GO:0009249 protein lipoylation(GO:0009249)
0.4 1.2 GO:0019343 cysteine biosynthetic process via cystathionine(GO:0019343) cysteine biosynthetic process(GO:0019344)
0.4 11.3 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.4 1.1 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743) alveolar secondary septum development(GO:0061144)
0.4 1.1 GO:0045113 regulation of integrin biosynthetic process(GO:0045113)
0.3 1.0 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.3 1.3 GO:0021978 telencephalon regionalization(GO:0021978)
0.3 0.9 GO:0038044 negative regulation of receptor biosynthetic process(GO:0010871) transforming growth factor-beta secretion(GO:0038044)
0.3 0.9 GO:0016554 cytidine to uridine editing(GO:0016554)
0.3 2.3 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406)
0.3 1.4 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.3 2.0 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.3 1.1 GO:0015889 cobalamin transport(GO:0015889)
0.3 1.0 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.3 1.8 GO:0015791 polyol transport(GO:0015791) bile acid secretion(GO:0032782)
0.3 0.8 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.2 0.7 GO:0090324 negative regulation of oxidative phosphorylation(GO:0090324)
0.2 0.7 GO:0060023 soft palate development(GO:0060023)
0.2 1.2 GO:2000987 positive regulation of fear response(GO:1903367) positive regulation of behavioral fear response(GO:2000987)
0.2 0.7 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.2 1.1 GO:0052695 cellular glucuronidation(GO:0052695)
0.2 0.4 GO:0042536 negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.2 1.5 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.2 0.6 GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
0.2 1.6 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.2 0.6 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.2 1.5 GO:0050957 equilibrioception(GO:0050957)
0.2 0.6 GO:0036233 glycine import(GO:0036233)
0.2 1.3 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.2 0.5 GO:0009826 unidimensional cell growth(GO:0009826) susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.2 6.7 GO:0006270 DNA replication initiation(GO:0006270)
0.2 0.3 GO:1904956 regulation of midbrain dopaminergic neuron differentiation(GO:1904956)
0.2 18.5 GO:0048706 embryonic skeletal system development(GO:0048706)
0.2 0.3 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.1 0.3 GO:0090365 regulation of mRNA modification(GO:0090365)
0.1 0.6 GO:0002326 B cell lineage commitment(GO:0002326)
0.1 0.4 GO:1904245 regulation of polynucleotide adenylyltransferase activity(GO:1904245)
0.1 1.5 GO:1902916 positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148) positive regulation of protein polyubiquitination(GO:1902916)
0.1 2.1 GO:0006337 nucleosome disassembly(GO:0006337)
0.1 1.4 GO:0060539 diaphragm development(GO:0060539)
0.1 3.7 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.1 1.4 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.1 2.0 GO:0030903 notochord development(GO:0030903)
0.1 0.9 GO:0032049 cardiolipin biosynthetic process(GO:0032049)
0.1 1.7 GO:0051764 actin crosslink formation(GO:0051764)
0.1 5.0 GO:0051693 actin filament capping(GO:0051693)
0.1 0.4 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.1 3.5 GO:0097352 autophagosome maturation(GO:0097352)
0.1 1.5 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.1 1.7 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.1 1.1 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.1 1.7 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.1 0.9 GO:0061470 interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619)
0.1 0.5 GO:0016078 tRNA catabolic process(GO:0016078)
0.1 0.9 GO:0043922 negative regulation by host of viral transcription(GO:0043922)
0.1 0.3 GO:0010360 negative regulation of anion channel activity(GO:0010360)
0.1 2.5 GO:0018345 protein palmitoylation(GO:0018345)
0.1 0.7 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1 0.8 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.1 0.3 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.1 1.5 GO:0035136 forelimb morphogenesis(GO:0035136)
0.1 0.9 GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization(GO:0060307)
0.1 6.8 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 0.4 GO:0045925 positive regulation of female receptivity(GO:0045925)
0.1 1.1 GO:0045332 phospholipid translocation(GO:0045332)
0.1 1.9 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 1.5 GO:0008340 determination of adult lifespan(GO:0008340)
0.1 0.5 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.1 1.2 GO:1901020 negative regulation of calcium ion transmembrane transporter activity(GO:1901020)
0.1 0.9 GO:0030497 fatty acid elongation(GO:0030497)
0.1 0.4 GO:0009396 folic acid-containing compound biosynthetic process(GO:0009396)
0.1 0.9 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.1 0.2 GO:2000510 positive regulation of dendritic cell chemotaxis(GO:2000510)
0.1 0.4 GO:0016584 nucleosome positioning(GO:0016584)
0.1 1.3 GO:0033194 response to hydroperoxide(GO:0033194)
0.0 0.7 GO:0071384 cellular response to corticosteroid stimulus(GO:0071384) cellular response to glucocorticoid stimulus(GO:0071385)
0.0 1.7 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 1.0 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 0.4 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.2 GO:0015692 vanadium ion transport(GO:0015676) lead ion transport(GO:0015692)
0.0 1.6 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.0 1.5 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 1.6 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 0.8 GO:0003351 epithelial cilium movement(GO:0003351)
0.0 1.4 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.0 0.1 GO:0043622 cortical microtubule organization(GO:0043622)
0.0 6.1 GO:0030178 negative regulation of Wnt signaling pathway(GO:0030178)
0.0 0.4 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 11.7 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 0.9 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 0.3 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.1 GO:0034285 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.0 0.7 GO:0006999 nuclear pore organization(GO:0006999)
0.0 0.6 GO:0007616 long-term memory(GO:0007616)
0.0 2.6 GO:0043488 regulation of mRNA stability(GO:0043488)
0.0 0.3 GO:0019388 galactose catabolic process(GO:0019388)
0.0 1.4 GO:0071774 response to fibroblast growth factor(GO:0071774)
0.0 0.2 GO:0071763 nuclear membrane organization(GO:0071763)
0.0 0.2 GO:0045602 negative regulation of endothelial cell differentiation(GO:0045602)
0.0 0.1 GO:1904338 positive regulation of Schwann cell migration(GO:1900149) regulation of dopaminergic neuron differentiation(GO:1904338)
0.0 0.3 GO:0090435 protein localization to nuclear envelope(GO:0090435)
0.0 3.0 GO:0007605 sensory perception of sound(GO:0007605)
0.0 0.4 GO:0002053 positive regulation of mesenchymal cell proliferation(GO:0002053)
0.0 0.1 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.0 1.4 GO:0050728 negative regulation of inflammatory response(GO:0050728)
0.0 0.9 GO:0051881 regulation of mitochondrial membrane potential(GO:0051881)
0.0 0.3 GO:0022904 respiratory electron transport chain(GO:0022904)
0.0 0.6 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.0 3.9 GO:0007059 chromosome segregation(GO:0007059)
0.0 0.2 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 0.2 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.0 0.2 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.6 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.0 0.3 GO:0007566 embryo implantation(GO:0007566)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 6.9 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.7 2.7 GO:0060187 cell pole(GO:0060187)
0.6 3.7 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.6 3.3 GO:0001674 female germ cell nucleus(GO:0001674)
0.4 4.6 GO:0005915 zonula adherens(GO:0005915)
0.4 14.5 GO:0032839 dendrite cytoplasm(GO:0032839)
0.4 9.9 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.3 0.9 GO:0034684 integrin alphav-beta5 complex(GO:0034684)
0.3 4.3 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.3 13.1 GO:0002102 podosome(GO:0002102)
0.3 1.2 GO:0032280 symmetric synapse(GO:0032280)
0.3 0.3 GO:0044301 climbing fiber(GO:0044301)
0.3 1.1 GO:0071438 NADPH oxidase complex(GO:0043020) invadopodium membrane(GO:0071438)
0.3 1.3 GO:0072487 MSL complex(GO:0072487)
0.3 1.3 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.2 2.0 GO:0033269 internode region of axon(GO:0033269)
0.2 0.7 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.2 2.6 GO:0042788 polysomal ribosome(GO:0042788)
0.2 1.7 GO:0071439 clathrin complex(GO:0071439)
0.2 6.2 GO:0032809 neuronal cell body membrane(GO:0032809)
0.2 0.6 GO:0031523 Myb complex(GO:0031523)
0.1 20.6 GO:0000792 heterochromatin(GO:0000792)
0.1 4.3 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 0.7 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.1 0.4 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.1 0.5 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.1 1.0 GO:0042555 MCM complex(GO:0042555)
0.1 0.6 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.1 2.2 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 0.9 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 1.1 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.1 2.1 GO:0043034 costamere(GO:0043034)
0.1 5.5 GO:0043198 dendritic shaft(GO:0043198)
0.1 1.2 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 0.5 GO:0070852 cell body fiber(GO:0070852)
0.0 0.4 GO:0016580 Sin3 complex(GO:0016580)
0.0 2.7 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 1.1 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.2 GO:0070826 paraferritin complex(GO:0070826)
0.0 0.6 GO:0033655 host cell cytoplasm(GO:0030430) host cell cytoplasm part(GO:0033655)
0.0 0.4 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 0.2 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 2.6 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.6 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.0 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.5 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 7.0 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 1.3 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.3 GO:0031527 filopodium membrane(GO:0031527)
0.0 0.4 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.9 GO:0000786 nucleosome(GO:0000786)
0.0 0.2 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.0 0.3 GO:0045120 pronucleus(GO:0045120)
0.0 9.3 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.2 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.0 0.8 GO:0005871 kinesin complex(GO:0005871)
0.0 1.6 GO:0016363 nuclear matrix(GO:0016363)
0.0 0.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.2 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 118.6 GO:0005634 nucleus(GO:0005634)
0.0 0.9 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 2.6 GO:0005925 focal adhesion(GO:0005925)
0.0 3.5 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.4 GO:0000776 kinetochore(GO:0000776)
0.0 12.0 GO:0005794 Golgi apparatus(GO:0005794)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 21.5 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
1.6 15.6 GO:0031852 mu-type opioid receptor binding(GO:0031852)
1.2 3.7 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.9 3.8 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.9 6.5 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.9 8.7 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.8 9.9 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.7 7.5 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.6 6.9 GO:0043522 leucine zipper domain binding(GO:0043522)
0.6 2.3 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.5 1.8 GO:0015254 glycerol channel activity(GO:0015254)
0.4 5.3 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.4 4.6 GO:0070097 delta-catenin binding(GO:0070097)
0.4 1.1 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.3 2.7 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.3 3.6 GO:0048185 activin binding(GO:0048185)
0.3 11.2 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.3 0.6 GO:0070644 vitamin D response element binding(GO:0070644)
0.3 0.9 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.3 0.8 GO:0047256 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
0.3 1.3 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.2 1.2 GO:0031628 opioid receptor binding(GO:0031628)
0.2 0.9 GO:0004126 cytidine deaminase activity(GO:0004126)
0.2 3.4 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.2 1.6 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.2 0.9 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.2 2.0 GO:0039706 co-receptor binding(GO:0039706) BMP receptor binding(GO:0070700)
0.2 4.5 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 1.6 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.2 0.9 GO:0019960 C-X3-C chemokine binding(GO:0019960) neuregulin binding(GO:0038132)
0.2 1.5 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.2 3.7 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.2 1.4 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.2 1.1 GO:0031419 cobalamin binding(GO:0031419)
0.2 19.6 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.2 2.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 6.1 GO:0015144 carbohydrate transmembrane transporter activity(GO:0015144) carbohydrate transporter activity(GO:1901476)
0.1 1.0 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 0.9 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 0.3 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.1 2.1 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 1.1 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.1 0.5 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.1 0.9 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.1 1.9 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 2.9 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 4.6 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 1.2 GO:1990405 protein antigen binding(GO:1990405)
0.1 36.0 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 3.5 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 0.5 GO:0043532 angiostatin binding(GO:0043532)
0.1 0.3 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.1 76.4 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.1 0.6 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.1 2.2 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 0.6 GO:0070728 leucine binding(GO:0070728)
0.1 0.7 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.1 12.1 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.1 0.8 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.1 2.5 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 2.6 GO:0017091 AU-rich element binding(GO:0017091)
0.1 1.3 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.1 1.4 GO:0008483 transaminase activity(GO:0008483)
0.1 1.1 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 0.3 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.1 0.8 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 1.2 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 2.0 GO:0005504 fatty acid binding(GO:0005504)
0.1 3.0 GO:0003690 double-stranded DNA binding(GO:0003690)
0.1 0.7 GO:0004000 adenosine deaminase activity(GO:0004000)
0.1 0.6 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.1 1.3 GO:0042605 peptide antigen binding(GO:0042605)
0.0 10.7 GO:0000287 magnesium ion binding(GO:0000287)
0.0 0.4 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 1.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.6 GO:0005537 mannose binding(GO:0005537)
0.0 1.6 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.2 GO:0015086 cadmium ion transmembrane transporter activity(GO:0015086) lead ion transmembrane transporter activity(GO:0015094) vanadium ion transmembrane transporter activity(GO:0015100) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.0 0.2 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.0 0.9 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0 5.5 GO:0003774 motor activity(GO:0003774)
0.0 15.0 GO:0003779 actin binding(GO:0003779)
0.0 1.5 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.4 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.4 GO:0005542 folic acid binding(GO:0005542)
0.0 0.2 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 0.9 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 0.2 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 0.1 GO:0097642 calcitonin family receptor activity(GO:0097642)
0.0 0.1 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 0.4 GO:0008143 poly(A) binding(GO:0008143)
0.0 1.8 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.5 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.7 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 0.2 GO:0005521 lamin binding(GO:0005521)
0.0 0.4 GO:0042169 SH2 domain binding(GO:0042169)
0.0 0.1 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 3.0 GO:0003924 GTPase activity(GO:0003924)
0.0 1.1 GO:0008236 serine-type peptidase activity(GO:0008236)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 31.7 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.3 8.7 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.2 21.2 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.2 6.2 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.1 6.7 PID_BMP_PATHWAY BMP receptor signaling
0.1 2.6 PID_MYC_PATHWAY C-MYC pathway
0.1 11.4 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 3.9 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.1 1.1 PID_S1P_S1P3_PATHWAY S1P3 pathway
0.1 1.1 PID_RAC1_PATHWAY RAC1 signaling pathway
0.1 4.6 PID_IL12_2PATHWAY IL12-mediated signaling events
0.1 7.9 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 4.6 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 6.1 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.1 2.9 PID_AP1_PATHWAY AP-1 transcription factor network
0.1 1.3 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 2.5 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 0.9 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.1 3.8 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 1.3 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.1 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.4 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 1.3 PID_PLK1_PATHWAY PLK1 signaling events
0.0 1.2 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 1.0 PID_ATR_PATHWAY ATR signaling pathway
0.0 1.3 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 0.4 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.6 PID_TCPTP_PATHWAY Signaling events mediated by TCPTP
0.0 0.3 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 0.7 PID_INTEGRIN1_PATHWAY Beta1 integrin cell surface interactions
0.0 0.4 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 0.4 PID_RHOA_REG_PATHWAY Regulation of RhoA activity

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 21.5 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.2 2.9 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.2 1.8 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.2 3.1 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.2 1.0 REACTOME_ANDROGEN_BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.1 12.4 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.1 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.1 1.0 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.1 9.7 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 4.3 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 8.3 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 0.6 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 1.3 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 2.5 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 1.0 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.1 0.6 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.1 1.4 REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.1 3.6 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 1.4 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 2.1 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 1.6 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport
0.1 0.8 REACTOME_PECAM1_INTERACTIONS Genes involved in PECAM1 interactions
0.0 1.2 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 3.3 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.9 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.9 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 1.5 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 1.1 REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 3.9 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.4 REACTOME_ACYL_CHAIN_REMODELLING_OF_PG Genes involved in Acyl chain remodelling of PG
0.0 0.4 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 1.0 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.5 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 1.0 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.5 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.6 REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.4 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 0.4 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.2 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.3 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.3 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)