Motif ID: Foxo6

Z-value: 0.460


Transcription factors associated with Foxo6:

Gene SymbolEntrez IDGene Name
Foxo6 ENSMUSG00000052135.8 Foxo6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxo6mm10_v2_chr4_-_120287349_120287349-0.114.9e-01Click!


Activity profile for motif Foxo6.

activity profile for motif Foxo6


Sorted Z-values histogram for motif Foxo6

Sorted Z-values for motif Foxo6



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxo6

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_12027958 2.929 ENSMUST00000109654.1
Grb10
growth factor receptor bound protein 10
chr5_+_110330697 2.363 ENSMUST00000112481.1
Pole
polymerase (DNA directed), epsilon
chr4_+_134510999 1.945 ENSMUST00000105866.2
Aunip
aurora kinase A and ninein interacting protein
chr10_-_93310963 1.739 ENSMUST00000151153.1
Elk3
ELK3, member of ETS oncogene family
chr10_-_93311073 1.636 ENSMUST00000008542.5
Elk3
ELK3, member of ETS oncogene family
chr1_+_74391479 1.576 ENSMUST00000027367.7
Ctdsp1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr1_+_51987139 1.576 ENSMUST00000168302.1
Stat4
signal transducer and activator of transcription 4
chrX_+_106920618 1.348 ENSMUST00000060576.7
Lpar4
lysophosphatidic acid receptor 4
chr14_-_47418407 1.339 ENSMUST00000043296.3
Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr6_-_23248264 1.241 ENSMUST00000031709.5
Fezf1
Fez family zinc finger 1
chr5_-_117389029 1.235 ENSMUST00000111953.1
ENSMUST00000086461.6
Rfc5

replication factor C (activator 1) 5

chr19_-_45742873 1.233 ENSMUST00000026241.5
ENSMUST00000026240.7
ENSMUST00000111928.1
Fgf8


fibroblast growth factor 8


chr5_+_7179299 1.212 ENSMUST00000179460.1
Tubb4b-ps1
tubulin, beta 4B class IVB, pseudogene 1
chr5_-_99037035 1.165 ENSMUST00000031277.6
Prkg2
protein kinase, cGMP-dependent, type II
chr17_-_24696147 1.155 ENSMUST00000046839.8
Gfer
growth factor, erv1 (S. cerevisiae)-like (augmenter of liver regeneration)
chrX_-_163761323 1.114 ENSMUST00000059320.2
Rnf138rt1
ring finger protein 138, retrogene 1
chr12_-_91384403 1.071 ENSMUST00000141429.1
Cep128
centrosomal protein 128
chrX_+_134585644 1.049 ENSMUST00000113211.1
Rpl36a
ribosomal protein L36A
chr7_+_28808795 0.928 ENSMUST00000172529.1
Hnrnpl
heterogeneous nuclear ribonucleoprotein L
chr17_-_31277327 0.829 ENSMUST00000024832.7
Rsph1
radial spoke head 1 homolog (Chlamydomonas)
chr17_-_57839233 0.725 ENSMUST00000095218.3
Rpl7a-ps5
ribosomal protein L7A, pseudogene 5
chrX_-_8193387 0.708 ENSMUST00000143223.1
ENSMUST00000033509.8
Ebp

phenylalkylamine Ca2+ antagonist (emopamil) binding protein

chrY_-_6681243 0.686 ENSMUST00000115940.1
Gm21719
predicted gene, 21719
chr2_-_84425258 0.678 ENSMUST00000074262.2
Calcrl
calcitonin receptor-like
chr5_-_65391408 0.636 ENSMUST00000057885.6
Rpl9
ribosomal protein L9
chr11_-_89639631 0.624 ENSMUST00000128717.1
Ankfn1
ankyrin-repeat and fibronectin type III domain containing 1
chr5_-_65391380 0.616 ENSMUST00000120094.1
ENSMUST00000118543.1
ENSMUST00000127874.1
Rpl9


ribosomal protein L9


chr15_-_81843699 0.593 ENSMUST00000092020.2
Gm8444
predicted gene 8444
chr12_+_108410542 0.560 ENSMUST00000054955.7
Eml1
echinoderm microtubule associated protein like 1
chr12_-_84617326 0.512 ENSMUST00000021666.4
Abcd4
ATP-binding cassette, sub-family D (ALD), member 4
chr3_-_51408925 0.498 ENSMUST00000038108.6
Ndufc1
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1
chr14_-_50924626 0.490 ENSMUST00000160375.1
ENSMUST00000162177.1
ENSMUST00000159292.1
Osgep


O-sialoglycoprotein endopeptidase


chr3_-_34351685 0.490 ENSMUST00000174114.1
Gm20514
predicted gene 20514
chr2_-_11603192 0.478 ENSMUST00000040314.5
Rbm17
RNA binding motif protein 17
chr8_+_36489191 0.464 ENSMUST00000171777.1
6430573F11Rik
RIKEN cDNA 6430573F11 gene
chr1_+_110099295 0.434 ENSMUST00000134301.1
Cdh7
cadherin 7, type 2
chr7_-_123369870 0.432 ENSMUST00000106442.2
ENSMUST00000098060.3
ENSMUST00000167309.1
Arhgap17


Rho GTPase activating protein 17


chr7_+_140881898 0.417 ENSMUST00000026560.7
Psmd13
proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
chr2_-_67194695 0.410 ENSMUST00000147939.1
Gm13598
predicted gene 13598
chr14_+_34170640 0.409 ENSMUST00000104925.3
Rpl23a-ps3
ribosomal protein L23A, pseudogene 3
chr5_+_115279666 0.405 ENSMUST00000040421.4
Coq5
coenzyme Q5 homolog, methyltransferase (yeast)
chr1_-_162898665 0.362 ENSMUST00000111510.1
ENSMUST00000045902.6
Fmo2

flavin containing monooxygenase 2

chr11_+_87853207 0.361 ENSMUST00000038196.6
Mks1
Meckel syndrome, type 1
chr2_+_129593195 0.349 ENSMUST00000099113.3
ENSMUST00000103202.3
Sirpa

signal-regulatory protein alpha

chr15_+_52712434 0.345 ENSMUST00000037115.7
Med30
mediator complex subunit 30
chr2_-_155357392 0.345 ENSMUST00000165234.1
ENSMUST00000077626.6
Pigu

phosphatidylinositol glycan anchor biosynthesis, class U

chr8_+_83566671 0.332 ENSMUST00000036996.5
Ndufb7
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7
chr2_+_4718145 0.326 ENSMUST00000056914.6
Bend7
BEN domain containing 7
chr18_-_60648290 0.326 ENSMUST00000143275.2
Synpo
synaptopodin
chr7_+_143052739 0.281 ENSMUST00000037941.9
Cd81
CD81 antigen
chr12_+_108410625 0.273 ENSMUST00000109857.1
Eml1
echinoderm microtubule associated protein like 1
chr7_+_28440927 0.270 ENSMUST00000078845.6
Gmfg
glia maturation factor, gamma
chr3_-_106167564 0.262 ENSMUST00000063062.8
Chi3l3
chitinase 3-like 3
chr16_+_10812915 0.261 ENSMUST00000115822.1
Gm11172
predicted gene 11172
chr13_-_71963713 0.256 ENSMUST00000077337.8
Irx1
Iroquois related homeobox 1 (Drosophila)
chr2_+_129592914 0.248 ENSMUST00000103203.1
Sirpa
signal-regulatory protein alpha
chr15_-_75111684 0.246 ENSMUST00000100542.3
Ly6c2
lymphocyte antigen 6 complex, locus C2
chr19_+_8892987 0.230 ENSMUST00000096249.5
Ints5
integrator complex subunit 5
chr9_+_25089422 0.227 ENSMUST00000086238.2
Gm10181
predicted gene 10181
chr5_+_44100442 0.211 ENSMUST00000072800.4
Gm16401
predicted gene 16401
chr19_+_44293676 0.195 ENSMUST00000026221.5
Scd2
stearoyl-Coenzyme A desaturase 2
chr5_+_65391497 0.190 ENSMUST00000031101.3
ENSMUST00000122026.1
Lias

lipoic acid synthetase

chr7_+_62476306 0.183 ENSMUST00000097132.3
Atp5l-ps1
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g, pseudogene 1
chr9_-_22071345 0.182 ENSMUST00000179605.1
ENSMUST00000043922.6
Zfp653

zinc finger protein 653

chr15_+_103453782 0.176 ENSMUST00000047405.7
Nckap1l
NCK associated protein 1 like
chr12_-_113260217 0.166 ENSMUST00000178282.1
Igha
immunoglobulin heavy constant alpha
chr1_-_160077918 0.137 ENSMUST00000028061.3
4930562F07Rik
RIKEN cDNA 4930562F07 gene
chr10_+_29313164 0.125 ENSMUST00000160399.1
Echdc1
enoyl Coenzyme A hydratase domain containing 1
chr7_+_19368498 0.123 ENSMUST00000132655.1
Ppp1r13l
protein phosphatase 1, regulatory (inhibitor) subunit 13 like
chr5_+_115605642 0.118 ENSMUST00000094427.3
Gcn1l1
GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
chr8_+_46986913 0.081 ENSMUST00000039840.7
ENSMUST00000119686.1
Enpp6

ectonucleotide pyrophosphatase/phosphodiesterase 6

chr6_+_88724667 0.080 ENSMUST00000163271.1
Mgll
monoglyceride lipase
chr11_+_46235460 0.079 ENSMUST00000060185.2
Fndc9
fibronectin type III domain containing 9
chr16_+_17146937 0.055 ENSMUST00000115706.1
ENSMUST00000069064.4
Ydjc

YdjC homolog (bacterial)

chr17_+_25471564 0.042 ENSMUST00000025002.1
Tekt4
tektin 4
chr4_-_149099802 0.041 ENSMUST00000103217.4
Pex14
peroxisomal biogenesis factor 14
chr18_-_31911903 0.032 ENSMUST00000054984.6
Sft2d3
SFT2 domain containing 3
chr2_-_75978164 0.023 ENSMUST00000099995.3
Ttc30a2
tetratricopeptide repeat domain 30A2
chr17_+_48346465 0.020 ENSMUST00000113237.3
Trem2
triggering receptor expressed on myeloid cells 2
chr3_+_103968110 0.007 ENSMUST00000117150.1
ENSMUST00000063717.7
ENSMUST00000055425.8
ENSMUST00000123611.1
ENSMUST00000090685.4
Phtf1




putative homeodomain transcription factor 1





Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0045004 DNA replication proofreading(GO:0045004)
0.4 1.2 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.3 2.9 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.2 1.2 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.2 0.7 GO:0034285 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.2 1.2 GO:2001225 cellular hypotonic response(GO:0071476) regulation of chloride transport(GO:2001225)
0.1 1.2 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.1 0.5 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.1 0.3 GO:0098886 modification of dendritic spine(GO:0098886)
0.1 1.2 GO:0097421 liver regeneration(GO:0097421)
0.1 0.9 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.1 0.4 GO:0072592 oxygen metabolic process(GO:0072592)
0.1 0.5 GO:0009235 cobalamin metabolic process(GO:0009235)
0.1 0.6 GO:0050957 equilibrioception(GO:0050957)
0.1 0.3 GO:0072272 proximal/distal pattern formation involved in metanephric nephron development(GO:0072272)
0.1 0.2 GO:0009106 lipoate metabolic process(GO:0009106)
0.1 1.3 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.1 0.2 GO:2001187 positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.1 0.3 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.1 0.3 GO:1904352 positive regulation of protein catabolic process in the vacuole(GO:1904352)
0.0 0.2 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.0 0.5 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.0 0.4 GO:0061009 common bile duct development(GO:0061009)
0.0 0.3 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
0.0 1.6 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.0 0.8 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.4 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.4 GO:0006744 ubiquinone biosynthetic process(GO:0006744)
0.0 0.8 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 1.3 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 0.8 GO:0035082 axoneme assembly(GO:0035082)
0.0 2.8 GO:0007051 spindle organization(GO:0007051)
0.0 0.0 GO:0016561 protein import into peroxisome matrix, translocation(GO:0016561)
0.0 0.1 GO:0019695 choline metabolic process(GO:0019695)
0.0 0.1 GO:1990253 cellular response to leucine starvation(GO:1990253)
0.0 0.7 GO:1902653 cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653)
0.0 0.1 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.0 0.2 GO:0016180 snRNA processing(GO:0016180)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.4 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.2 1.2 GO:0005663 DNA replication factor C complex(GO:0005663)
0.1 0.8 GO:0001520 outer dense fiber(GO:0001520)
0.1 0.5 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.1 0.8 GO:1990023 mitotic spindle midzone(GO:1990023)
0.1 1.3 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 0.3 GO:0097444 spine apparatus(GO:0097444)
0.1 0.3 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.9 GO:0045120 pronucleus(GO:0045120)
0.0 0.4 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 2.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 3.0 GO:0000922 spindle pole(GO:0000922)
0.0 0.4 GO:0036038 MKS complex(GO:0036038)
0.0 0.8 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.2 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.2 GO:0032039 integrator complex(GO:0032039)
0.0 0.2 GO:0031209 SCAR complex(GO:0031209)
0.0 0.0 GO:1990415 Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.4 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.8 2.4 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.4 1.2 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.3 1.2 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.3 1.2 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.2 0.7 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.2 1.3 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.2 1.6 GO:0008420 CTD phosphatase activity(GO:0008420)
0.2 0.5 GO:0061711 N(6)-L-threonylcarbamoyladenine synthase(GO:0061711)
0.1 1.2 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 0.9 GO:1990715 mRNA CDS binding(GO:1990715)
0.1 0.7 GO:0097642 calcitonin family receptor activity(GO:0097642)
0.1 0.5 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.1 2.9 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 0.4 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 0.3 GO:0034235 GPI anchor binding(GO:0034235)
0.1 0.2 GO:0016979 lipoate-protein ligase activity(GO:0016979)
0.0 0.2 GO:0032896 palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.0 0.1 GO:0004492 methylmalonyl-CoA decarboxylase activity(GO:0004492)
0.0 1.1 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.3 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.3 GO:1990459 virus receptor activity(GO:0001618) transferrin receptor binding(GO:1990459)
0.0 1.3 GO:0019843 rRNA binding(GO:0019843)
0.0 0.3 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.2 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.1 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 1.6 PID_IL27_PATHWAY IL27-mediated signaling events
0.1 2.9 PID_IGF1_PATHWAY IGF1 pathway
0.1 1.6 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.3 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 1.2 PID_ATR_PATHWAY ATR signaling pathway
0.0 1.2 PID_FGF_PATHWAY FGF signaling pathway
0.0 0.7 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.6 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.2 1.2 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.1 1.3 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.1 2.9 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.1 1.2 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.6 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.7 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.2 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 2.3 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.0 0.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.4 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.3 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.8 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport