Motif ID: Hoxa10
Z-value: 0.813

Transcription factors associated with Hoxa10:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Hoxa10 | ENSMUSG00000000938.11 | Hoxa10 |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.8 | 5.5 | GO:0016095 | polyprenol catabolic process(GO:0016095) terpenoid catabolic process(GO:0016115) primary alcohol catabolic process(GO:0034310) |
1.5 | 4.5 | GO:1902714 | negative regulation of interferon-gamma secretion(GO:1902714) |
0.5 | 2.1 | GO:0099566 | regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566) |
0.5 | 4.5 | GO:0071493 | cellular response to UV-B(GO:0071493) |
0.5 | 3.3 | GO:0070779 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
0.3 | 1.3 | GO:2000158 | positive regulation of ubiquitin-specific protease activity(GO:2000158) |
0.3 | 1.9 | GO:0045919 | complement activation, alternative pathway(GO:0006957) positive regulation of cytolysis(GO:0045919) |
0.2 | 1.0 | GO:0032914 | positive regulation of transforming growth factor beta1 production(GO:0032914) |
0.2 | 4.3 | GO:0046069 | cGMP catabolic process(GO:0046069) |
0.2 | 1.3 | GO:0007258 | JUN phosphorylation(GO:0007258) |
0.2 | 1.9 | GO:0031547 | brain-derived neurotrophic factor receptor signaling pathway(GO:0031547) |
0.2 | 0.8 | GO:0044861 | protein transport into plasma membrane raft(GO:0044861) |
0.2 | 1.0 | GO:0032485 | regulation of Ral protein signal transduction(GO:0032485) |
0.2 | 1.2 | GO:0015014 | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014) |
0.2 | 0.5 | GO:2000620 | positive regulation of histone H4-K16 acetylation(GO:2000620) |
0.2 | 1.6 | GO:0071420 | cellular response to histamine(GO:0071420) |
0.2 | 1.2 | GO:0021555 | midbrain-hindbrain boundary morphogenesis(GO:0021555) |
0.2 | 0.7 | GO:1902268 | negative regulation of polyamine transmembrane transport(GO:1902268) |
0.2 | 1.1 | GO:0060923 | cardiac muscle cell fate commitment(GO:0060923) |
0.2 | 1.4 | GO:0006682 | galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375) |
0.1 | 4.1 | GO:0007617 | mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705) |
0.1 | 1.3 | GO:0046085 | adenosine metabolic process(GO:0046085) |
0.1 | 0.6 | GO:0033762 | response to glucagon(GO:0033762) |
0.1 | 0.4 | GO:0070212 | protein poly-ADP-ribosylation(GO:0070212) |
0.1 | 2.0 | GO:0010603 | regulation of cytoplasmic mRNA processing body assembly(GO:0010603) |
0.1 | 1.3 | GO:0021869 | forebrain ventricular zone progenitor cell division(GO:0021869) |
0.1 | 0.3 | GO:1904139 | microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139) |
0.1 | 0.3 | GO:0019805 | quinolinate biosynthetic process(GO:0019805) |
0.1 | 0.4 | GO:1902774 | late endosome to lysosome transport(GO:1902774) |
0.1 | 0.4 | GO:1902683 | regulation of receptor localization to synapse(GO:1902683) |
0.1 | 0.9 | GO:0021942 | radial glia guided migration of Purkinje cell(GO:0021942) |
0.1 | 0.2 | GO:0002191 | cap-dependent translational initiation(GO:0002191) |
0.1 | 3.3 | GO:0007026 | negative regulation of microtubule depolymerization(GO:0007026) |
0.1 | 0.2 | GO:1903244 | positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244) regulation of connective tissue replacement(GO:1905203) |
0.1 | 0.4 | GO:0019695 | choline metabolic process(GO:0019695) |
0.0 | 0.4 | GO:0006930 | substrate-dependent cell migration, cell extension(GO:0006930) |
0.0 | 0.7 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
0.0 | 1.3 | GO:0007638 | mechanosensory behavior(GO:0007638) |
0.0 | 0.5 | GO:0051574 | positive regulation of histone H3-K9 methylation(GO:0051574) |
0.0 | 1.2 | GO:0035025 | positive regulation of Rho protein signal transduction(GO:0035025) |
0.0 | 0.4 | GO:0042572 | retinol metabolic process(GO:0042572) |
0.0 | 0.2 | GO:0030382 | sperm mitochondrion organization(GO:0030382) |
0.0 | 1.4 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
0.0 | 1.5 | GO:0030317 | sperm motility(GO:0030317) |
0.0 | 0.6 | GO:0021692 | cerebellar Purkinje cell layer morphogenesis(GO:0021692) |
0.0 | 0.5 | GO:0043968 | histone H2A acetylation(GO:0043968) |
0.0 | 0.5 | GO:0007097 | nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023) |
0.0 | 0.1 | GO:0002408 | myeloid dendritic cell chemotaxis(GO:0002408) |
0.0 | 0.4 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
0.0 | 0.8 | GO:0048013 | ephrin receptor signaling pathway(GO:0048013) |
0.0 | 0.5 | GO:0010758 | regulation of macrophage chemotaxis(GO:0010758) |
0.0 | 0.6 | GO:0051930 | regulation of sensory perception of pain(GO:0051930) regulation of sensory perception(GO:0051931) |
0.0 | 0.6 | GO:1901522 | positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522) |
0.0 | 0.1 | GO:0048254 | snoRNA localization(GO:0048254) |
0.0 | 0.4 | GO:0006825 | copper ion transport(GO:0006825) |
0.0 | 0.2 | GO:0006362 | transcription elongation from RNA polymerase I promoter(GO:0006362) |
0.0 | 0.6 | GO:1990830 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
0.0 | 0.5 | GO:1903077 | negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376) |
0.0 | 0.8 | GO:0051865 | protein autoubiquitination(GO:0051865) |
0.0 | 1.0 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
0.0 | 1.3 | GO:0008203 | cholesterol metabolic process(GO:0008203) |
0.0 | 0.0 | GO:0034184 | positive regulation of maintenance of sister chromatid cohesion(GO:0034093) positive regulation of maintenance of mitotic sister chromatid cohesion(GO:0034184) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.5 | 4.5 | GO:0070557 | PCNA-p21 complex(GO:0070557) |
0.3 | 0.9 | GO:0043224 | nuclear SCF ubiquitin ligase complex(GO:0043224) |
0.3 | 1.9 | GO:0044308 | axonal spine(GO:0044308) |
0.2 | 2.2 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
0.2 | 0.6 | GO:0044299 | C-fiber(GO:0044299) |
0.2 | 2.1 | GO:0038037 | G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648) |
0.1 | 0.8 | GO:0044352 | pinosome(GO:0044352) macropinosome(GO:0044354) |
0.1 | 1.6 | GO:1902710 | GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711) |
0.1 | 0.6 | GO:0008091 | spectrin(GO:0008091) |
0.1 | 3.3 | GO:0030673 | axolemma(GO:0030673) |
0.1 | 1.1 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
0.1 | 0.7 | GO:0005786 | signal recognition particle, endoplasmic reticulum targeting(GO:0005786) |
0.1 | 1.0 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
0.1 | 1.1 | GO:0043196 | varicosity(GO:0043196) |
0.1 | 0.4 | GO:0033263 | CORVET complex(GO:0033263) |
0.1 | 0.6 | GO:0045275 | respiratory chain complex III(GO:0045275) |
0.0 | 0.3 | GO:0030015 | CCR4-NOT core complex(GO:0030015) |
0.0 | 0.2 | GO:0005955 | calcineurin complex(GO:0005955) |
0.0 | 0.1 | GO:0071006 | U2-type catalytic step 1 spliceosome(GO:0071006) |
0.0 | 0.4 | GO:1990023 | mitotic spindle midzone(GO:1990023) |
0.0 | 0.2 | GO:0035032 | phosphatidylinositol 3-kinase complex, class III(GO:0035032) |
0.0 | 2.6 | GO:0072562 | blood microparticle(GO:0072562) |
0.0 | 0.2 | GO:0097227 | sperm annulus(GO:0097227) |
0.0 | 0.5 | GO:0043189 | NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562) |
0.0 | 1.7 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
0.0 | 0.5 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
0.0 | 1.0 | GO:0045202 | synapse(GO:0045202) |
0.0 | 0.2 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
0.0 | 0.2 | GO:0000439 | core TFIIH complex(GO:0000439) |
0.0 | 0.1 | GO:0031428 | box C/D snoRNP complex(GO:0031428) |
0.0 | 0.2 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
0.0 | 1.3 | GO:0043204 | perikaryon(GO:0043204) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.5 | 4.5 | GO:0019912 | cyclin-dependent protein kinase activating kinase activity(GO:0019912) |
1.1 | 5.5 | GO:0004032 | alditol:NADP+ 1-oxidoreductase activity(GO:0004032) |
0.8 | 4.5 | GO:0016936 | galactoside binding(GO:0016936) |
0.6 | 4.3 | GO:0048101 | calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
0.5 | 3.3 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
0.5 | 2.1 | GO:0001639 | PLC activating G-protein coupled glutamate receptor activity(GO:0001639) G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530) |
0.5 | 1.9 | GO:0001851 | complement component C3b binding(GO:0001851) |
0.4 | 3.3 | GO:0005519 | cytoskeletal regulatory protein binding(GO:0005519) |
0.4 | 1.4 | GO:0047275 | glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275) |
0.3 | 1.3 | GO:0016909 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
0.3 | 1.3 | GO:0035800 | deubiquitinase activator activity(GO:0035800) |
0.3 | 1.2 | GO:0042328 | heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328) |
0.3 | 3.8 | GO:0070742 | C2H2 zinc finger domain binding(GO:0070742) |
0.2 | 1.9 | GO:0015386 | potassium:proton antiporter activity(GO:0015386) |
0.2 | 0.7 | GO:0008073 | ornithine decarboxylase inhibitor activity(GO:0008073) |
0.2 | 1.3 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
0.1 | 0.9 | GO:0019788 | NEDD8 transferase activity(GO:0019788) |
0.1 | 1.7 | GO:0050692 | DBD domain binding(GO:0050692) |
0.1 | 0.6 | GO:0004886 | 9-cis retinoic acid receptor activity(GO:0004886) |
0.1 | 0.5 | GO:0030942 | endoplasmic reticulum signal peptide binding(GO:0030942) |
0.1 | 0.4 | GO:0033883 | pyridoxal phosphatase activity(GO:0033883) |
0.1 | 1.6 | GO:0004890 | GABA-A receptor activity(GO:0004890) |
0.1 | 1.3 | GO:0008253 | 5'-nucleotidase activity(GO:0008253) |
0.1 | 0.6 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
0.1 | 0.4 | GO:0004322 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
0.1 | 1.2 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
0.1 | 4.1 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
0.1 | 0.2 | GO:0008312 | 7S RNA binding(GO:0008312) |
0.1 | 0.5 | GO:0030550 | acetylcholine receptor inhibitor activity(GO:0030550) |
0.1 | 0.4 | GO:0008106 | alcohol dehydrogenase (NADP+) activity(GO:0008106) |
0.0 | 0.8 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
0.0 | 0.4 | GO:0008889 | glycerophosphodiester phosphodiesterase activity(GO:0008889) |
0.0 | 0.3 | GO:0001226 | RNA polymerase II transcription corepressor binding(GO:0001226) |
0.0 | 0.3 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
0.0 | 0.2 | GO:0071074 | eukaryotic initiation factor eIF2 binding(GO:0071074) |
0.0 | 1.3 | GO:0031435 | mitogen-activated protein kinase kinase kinase binding(GO:0031435) |
0.0 | 0.2 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
0.0 | 0.4 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
0.0 | 0.4 | GO:0070403 | NAD+ binding(GO:0070403) |
0.0 | 0.6 | GO:0005248 | voltage-gated sodium channel activity(GO:0005248) |
0.0 | 1.2 | GO:0098811 | transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811) |
0.0 | 0.4 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
0.0 | 3.9 | GO:0005516 | calmodulin binding(GO:0005516) |
0.0 | 1.3 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
0.0 | 0.7 | GO:0008536 | Ran GTPase binding(GO:0008536) |
0.0 | 1.0 | GO:0005518 | collagen binding(GO:0005518) |
0.0 | 0.1 | GO:0001094 | TFIID-class transcription factor binding(GO:0001094) |
0.0 | 0.2 | GO:0000182 | rDNA binding(GO:0000182) |
0.0 | 0.5 | GO:0032452 | histone demethylase activity(GO:0032452) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 4.5 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
0.0 | 4.5 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
0.0 | 2.4 | ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
0.0 | 1.0 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
0.0 | 2.2 | PID_LKB1_PATHWAY | LKB1 signaling events |
0.0 | 0.4 | PID_SYNDECAN_3_PATHWAY | Syndecan-3-mediated signaling events |
0.0 | 0.2 | PID_NEPHRIN_NEPH1_PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
0.0 | 0.6 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
0.0 | 0.5 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
0.0 | 0.6 | PID_TRKR_PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
0.0 | 0.4 | PID_IL4_2PATHWAY | IL4-mediated signaling events |
0.0 | 0.8 | PID_MTOR_4PATHWAY | mTOR signaling pathway |
0.0 | 0.2 | PID_IL3_PATHWAY | IL3-mediated signaling events |
0.0 | 1.0 | PID_ERBB1_DOWNSTREAM_PATHWAY | ErbB1 downstream signaling |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 1.9 | REACTOME_REGULATION_OF_COMPLEMENT_CASCADE | Genes involved in Regulation of Complement cascade |
0.2 | 1.3 | REACTOME_ENDOGENOUS_STEROLS | Genes involved in Endogenous sterols |
0.2 | 4.5 | REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
0.2 | 4.3 | REACTOME_CGMP_EFFECTS | Genes involved in cGMP effects |
0.2 | 2.1 | REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
0.1 | 1.3 | REACTOME_PYRIMIDINE_CATABOLISM | Genes involved in Pyrimidine catabolism |
0.1 | 1.6 | REACTOME_GABA_A_RECEPTOR_ACTIVATION | Genes involved in GABA A receptor activation |
0.1 | 1.0 | REACTOME_KERATAN_SULFATE_DEGRADATION | Genes involved in Keratan sulfate degradation |
0.1 | 1.3 | REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
0.1 | 1.3 | REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
0.1 | 3.3 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
0.0 | 3.8 | REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
0.0 | 0.3 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
0.0 | 0.3 | REACTOME_TRYPTOPHAN_CATABOLISM | Genes involved in Tryptophan catabolism |
0.0 | 1.2 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
0.0 | 0.5 | REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
0.0 | 1.1 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
0.0 | 0.6 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
0.0 | 1.9 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
0.0 | 0.4 | REACTOME_METAL_ION_SLC_TRANSPORTERS | Genes involved in Metal ion SLC transporters |
0.0 | 0.3 | REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
0.0 | 0.2 | REACTOME_ACTIVATION_OF_RAC | Genes involved in Activation of Rac |
0.0 | 0.7 | REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
0.0 | 0.3 | REACTOME_DEADENYLATION_OF_MRNA | Genes involved in Deadenylation of mRNA |
0.0 | 0.2 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |