Motif ID: Pax6
Z-value: 0.706

Transcription factors associated with Pax6:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Pax6 | ENSMUSG00000027168.15 | Pax6 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Pax6 | mm10_v2_chr2_+_105682463_105682547 | -0.77 | 4.5e-09 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.1 | 3.4 | GO:1903588 | negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588) |
0.6 | 1.9 | GO:0032696 | negative regulation of interleukin-13 production(GO:0032696) negative regulation of interleukin-10 secretion(GO:2001180) |
0.6 | 1.7 | GO:0002538 | arachidonic acid metabolite production involved in inflammatory response(GO:0002538) |
0.4 | 1.8 | GO:0010040 | response to iron(II) ion(GO:0010040) positive regulation of hydrogen peroxide metabolic process(GO:0010726) negative regulation of synaptic transmission, dopaminergic(GO:0032227) negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963) regulation of peroxidase activity(GO:2000468) |
0.4 | 1.2 | GO:0098974 | postsynaptic actin cytoskeleton organization(GO:0098974) |
0.3 | 2.1 | GO:1990416 | cellular response to brain-derived neurotrophic factor stimulus(GO:1990416) |
0.2 | 1.2 | GO:0015671 | oxygen transport(GO:0015671) |
0.2 | 0.5 | GO:0060743 | epithelial cell maturation involved in prostate gland development(GO:0060743) |
0.2 | 0.6 | GO:1904778 | regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778) |
0.2 | 0.6 | GO:1903542 | negative regulation of exosomal secretion(GO:1903542) |
0.1 | 0.7 | GO:0007603 | phototransduction, visible light(GO:0007603) |
0.1 | 0.4 | GO:1902260 | negative regulation of delayed rectifier potassium channel activity(GO:1902260) |
0.1 | 0.4 | GO:0090204 | protein localization to nuclear pore(GO:0090204) negative regulation of vascular endothelial growth factor production(GO:1904046) |
0.1 | 2.7 | GO:0099612 | protein localization to axon(GO:0099612) |
0.1 | 0.3 | GO:0050915 | sensory perception of sour taste(GO:0050915) |
0.1 | 0.7 | GO:0009098 | branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099) |
0.1 | 0.4 | GO:1902340 | telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340) |
0.1 | 0.9 | GO:0038203 | TORC2 signaling(GO:0038203) |
0.1 | 0.4 | GO:0051661 | maintenance of centrosome location(GO:0051661) |
0.1 | 0.3 | GO:0060708 | spongiotrophoblast differentiation(GO:0060708) |
0.1 | 1.0 | GO:0002347 | response to tumor cell(GO:0002347) |
0.1 | 0.2 | GO:0006667 | sphinganine metabolic process(GO:0006667) |
0.1 | 0.2 | GO:1900369 | negative regulation of RNA interference(GO:1900369) regulation of histone demethylase activity (H3-K4 specific)(GO:1904173) |
0.1 | 0.2 | GO:0060083 | smooth muscle contraction involved in micturition(GO:0060083) |
0.1 | 0.3 | GO:0097527 | necroptotic signaling pathway(GO:0097527) |
0.0 | 0.2 | GO:0006384 | transcription initiation from RNA polymerase III promoter(GO:0006384) |
0.0 | 0.2 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
0.0 | 0.5 | GO:0006654 | phosphatidic acid biosynthetic process(GO:0006654) |
0.0 | 0.1 | GO:0002430 | complement receptor mediated signaling pathway(GO:0002430) |
0.0 | 0.3 | GO:0090043 | regulation of tubulin deacetylation(GO:0090043) |
0.0 | 0.2 | GO:0060414 | response to potassium ion(GO:0035864) cellular response to potassium ion(GO:0035865) aorta smooth muscle tissue morphogenesis(GO:0060414) |
0.0 | 0.2 | GO:0014816 | skeletal muscle satellite cell differentiation(GO:0014816) |
0.0 | 1.9 | GO:0019882 | antigen processing and presentation(GO:0019882) |
0.0 | 0.1 | GO:0030242 | pexophagy(GO:0030242) |
0.0 | 0.6 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
0.0 | 0.1 | GO:0033140 | negative regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033140) |
0.0 | 0.2 | GO:0071624 | positive regulation of granulocyte chemotaxis(GO:0071624) positive regulation of neutrophil chemotaxis(GO:0090023) |
0.0 | 0.1 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
0.0 | 0.3 | GO:1904355 | positive regulation of telomere capping(GO:1904355) |
0.0 | 0.2 | GO:0050832 | defense response to fungus(GO:0050832) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.7 | 2.7 | GO:1990769 | proximal neuron projection(GO:1990769) |
0.4 | 1.8 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
0.1 | 1.2 | GO:0005833 | hemoglobin complex(GO:0005833) |
0.1 | 3.4 | GO:0045334 | clathrin-coated endocytic vesicle(GO:0045334) |
0.1 | 0.6 | GO:0097208 | alveolar lamellar body(GO:0097208) |
0.1 | 0.7 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
0.1 | 0.4 | GO:0001740 | Barr body(GO:0001740) |
0.1 | 0.9 | GO:0031932 | TORC2 complex(GO:0031932) |
0.0 | 0.2 | GO:0001533 | cornified envelope(GO:0001533) |
0.0 | 0.4 | GO:0044613 | nuclear pore central transport channel(GO:0044613) |
0.0 | 1.2 | GO:0043189 | NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562) |
0.0 | 0.2 | GO:0035339 | SPOTS complex(GO:0035339) |
0.0 | 1.2 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
0.0 | 0.1 | GO:0034272 | phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272) |
0.0 | 0.3 | GO:0031265 | CD95 death-inducing signaling complex(GO:0031265) |
0.0 | 0.2 | GO:0005851 | eukaryotic translation initiation factor 2B complex(GO:0005851) |
0.0 | 0.4 | GO:1990635 | proximal dendrite(GO:1990635) |
0.0 | 0.2 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
0.0 | 0.6 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
0.0 | 0.4 | GO:0031616 | spindle pole centrosome(GO:0031616) |
0.0 | 0.3 | GO:0030126 | COPI vesicle coat(GO:0030126) |
0.0 | 0.3 | GO:0000124 | SAGA complex(GO:0000124) |
0.0 | 0.6 | GO:0099738 | cell cortex region(GO:0099738) |
0.0 | 0.1 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 3.4 | GO:0050544 | arachidonic acid binding(GO:0050544) |
0.4 | 1.2 | GO:0098973 | structural constituent of synapse(GO:0098918) structural constituent of postsynaptic actin cytoskeleton(GO:0098973) |
0.3 | 3.4 | GO:0048406 | neurotrophin TRKA receptor binding(GO:0005168) nerve growth factor binding(GO:0048406) |
0.3 | 1.2 | GO:0031721 | hemoglobin alpha binding(GO:0031721) |
0.2 | 0.7 | GO:0000026 | alpha-1,2-mannosyltransferase activity(GO:0000026) |
0.1 | 2.1 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
0.1 | 0.3 | GO:0008527 | taste receptor activity(GO:0008527) |
0.1 | 0.7 | GO:0052654 | branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656) |
0.1 | 0.6 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) |
0.1 | 0.3 | GO:0019912 | cyclin-dependent protein kinase activating kinase activity(GO:0019912) |
0.1 | 0.7 | GO:0047391 | alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391) |
0.1 | 1.9 | GO:0031489 | myosin V binding(GO:0031489) |
0.1 | 0.2 | GO:0004758 | serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454) |
0.0 | 0.2 | GO:0086056 | voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056) |
0.0 | 1.4 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
0.0 | 0.5 | GO:0005123 | death receptor binding(GO:0005123) |
0.0 | 0.4 | GO:0004033 | aldo-keto reductase (NADP) activity(GO:0004033) |
0.0 | 0.2 | GO:0019869 | chloride channel inhibitor activity(GO:0019869) |
0.0 | 0.5 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
0.0 | 0.1 | GO:0004875 | complement receptor activity(GO:0004875) |
0.0 | 0.2 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
0.0 | 0.2 | GO:0003964 | telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964) |
0.0 | 0.1 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
0.0 | 0.4 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
0.0 | 0.6 | GO:0019003 | GDP binding(GO:0019003) |
0.0 | 0.0 | GO:0015143 | urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 3.4 | SA_TRKA_RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
0.1 | 0.7 | PID_RHODOPSIN_PATHWAY | Visual signal transduction: Rods |
0.1 | 0.6 | PID_S1P_S1P4_PATHWAY | S1P4 pathway |
0.0 | 1.8 | PID_ALPHA_SYNUCLEIN_PATHWAY | Alpha-synuclein signaling |
0.0 | 2.1 | PID_ERBB1_INTERNALIZATION_PATHWAY | Internalization of ErbB1 |
0.0 | 0.3 | SA_FAS_SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
0.0 | 0.1 | PID_PI3K_PLC_TRK_PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
0.0 | 0.9 | PID_MTOR_4PATHWAY | mTOR signaling pathway |
0.0 | 1.2 | WNT_SIGNALING | Genes related to Wnt-mediated signal transduction |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 3.4 | REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL | Genes involved in NF-kB is activated and signals survival |
0.1 | 0.7 | REACTOME_OLFACTORY_SIGNALING_PATHWAY | Genes involved in Olfactory Signaling Pathway |
0.1 | 2.1 | REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
0.1 | 2.7 | REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS | Genes involved in O-linked glycosylation of mucins |
0.0 | 0.6 | REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY | Genes involved in Adenylate cyclase inhibitory pathway |
0.0 | 2.2 | REACTOME_AMYLOIDS | Genes involved in Amyloids |
0.0 | 1.2 | REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC | Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC |
0.0 | 0.7 | REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
0.0 | 0.6 | REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
0.0 | 0.7 | REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
0.0 | 0.3 | REACTOME_COPI_MEDIATED_TRANSPORT | Genes involved in COPI Mediated Transport |
0.0 | 0.5 | REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING | Genes involved in DCC mediated attractive signaling |
0.0 | 0.3 | REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
0.0 | 0.2 | REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
0.0 | 1.9 | REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION | Genes involved in PPARA Activates Gene Expression |
0.0 | 0.5 | REACTOME_SYNTHESIS_OF_PA | Genes involved in Synthesis of PA |
0.0 | 0.4 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |