Motif ID: Grhl1

Z-value: 0.424


Transcription factors associated with Grhl1:

Gene SymbolEntrez IDGene Name
Grhl1 ENSMUSG00000020656.9 Grhl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Grhl1mm10_v2_chr12_+_24572276_24572308-0.057.6e-01Click!


Activity profile for motif Grhl1.

activity profile for motif Grhl1


Sorted Z-values histogram for motif Grhl1

Sorted Z-values for motif Grhl1



Network of associatons between targets according to the STRING database.



First level regulatory network of Grhl1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_87635974 1.719 ENSMUST00000053577.8
Epcam
epithelial cell adhesion molecule
chr16_-_26989974 1.574 ENSMUST00000089832.4
Gmnc
geminin coiled-coil domain containing
chrX_+_100730178 1.565 ENSMUST00000113744.1
Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chr2_-_105399286 1.349 ENSMUST00000006128.6
Rcn1
reticulocalbin 1
chr2_-_151973387 1.348 ENSMUST00000109863.1
Fam110a
family with sequence similarity 110, member A
chr8_-_71381907 1.083 ENSMUST00000002466.8
Nr2f6
nuclear receptor subfamily 2, group F, member 6
chr18_+_56432116 0.818 ENSMUST00000070166.5
Gramd3
GRAM domain containing 3
chr7_+_101321703 0.770 ENSMUST00000174291.1
ENSMUST00000167888.2
ENSMUST00000172662.1
ENSMUST00000173270.1
ENSMUST00000174083.1
Stard10




START domain containing 10




chr14_-_57133268 0.755 ENSMUST00000160703.1
Gjb6
gap junction protein, beta 6
chr2_+_172550761 0.749 ENSMUST00000099058.3
Tfap2c
transcription factor AP-2, gamma
chr13_+_8885501 0.715 ENSMUST00000169314.2
Idi1
isopentenyl-diphosphate delta isomerase
chr17_-_56005566 0.639 ENSMUST00000043785.6
Stap2
signal transducing adaptor family member 2
chr4_+_109676568 0.634 ENSMUST00000102724.4
Faf1
Fas-associated factor 1
chr14_+_75136326 0.607 ENSMUST00000145303.1
Lcp1
lymphocyte cytosolic protein 1
chr6_+_128438757 0.596 ENSMUST00000144745.1
Gm10069
predicted gene 10069
chr10_+_128747850 0.594 ENSMUST00000163377.2
Wibg
within bgcn homolog (Drosophila)
chr4_+_141242850 0.585 ENSMUST00000138096.1
ENSMUST00000006618.2
ENSMUST00000125392.1
Arhgef19


Rho guanine nucleotide exchange factor (GEF) 19


chr10_-_79533750 0.565 ENSMUST00000166804.1
ENSMUST00000063879.5
Ppap2c

phosphatidic acid phosphatase type 2C

chr14_-_79481268 0.534 ENSMUST00000022601.5
Wbp4
WW domain binding protein 4
chr14_+_79481164 0.518 ENSMUST00000040131.5
Elf1
E74-like factor 1
chr7_+_65693417 0.479 ENSMUST00000032726.7
ENSMUST00000107495.3
Tm2d3

TM2 domain containing 3

chr14_+_63943666 0.462 ENSMUST00000079652.5
Sox7
SRY-box containing gene 7
chr12_+_76417598 0.459 ENSMUST00000063977.7
Ppp1r36
protein phosphatase 1, regulatory subunit 36
chr3_-_87263703 0.451 ENSMUST00000146512.1
Fcrls
Fc receptor-like S, scavenger receptor
chr17_-_34628380 0.442 ENSMUST00000167097.2
Ppt2
palmitoyl-protein thioesterase 2
chr3_-_87263518 0.429 ENSMUST00000090986.4
Fcrls
Fc receptor-like S, scavenger receptor
chr7_+_65693447 0.422 ENSMUST00000143508.1
Tm2d3
TM2 domain containing 3
chr10_-_128565827 0.412 ENSMUST00000131728.1
ENSMUST00000026425.6
Pa2g4

proliferation-associated 2G4

chrX_-_38456407 0.401 ENSMUST00000074913.5
ENSMUST00000016678.7
ENSMUST00000061755.8
Lamp2


lysosomal-associated membrane protein 2


chr7_+_12927410 0.382 ENSMUST00000045870.4
2310014L17Rik
RIKEN cDNA 2310014L17 gene
chr9_-_44268156 0.359 ENSMUST00000169651.1
Nlrx1
NLR family member X1
chr1_+_135818593 0.317 ENSMUST00000038760.8
Lad1
ladinin
chr12_-_54656496 0.301 ENSMUST00000056228.6
Sptssa
serine palmitoyltransferase, small subunit A
chr17_+_43389436 0.292 ENSMUST00000113599.1
Gpr116
G protein-coupled receptor 116
chr6_-_113377510 0.253 ENSMUST00000099118.2
Tada3
transcriptional adaptor 3
chr8_+_80494032 0.244 ENSMUST00000063359.6
Gypa
glycophorin A
chr17_-_34628005 0.224 ENSMUST00000166040.2
Ppt2
palmitoyl-protein thioesterase 2
chr19_-_18631754 0.203 ENSMUST00000025631.6
Ostf1
osteoclast stimulating factor 1
chr9_+_15239045 0.201 ENSMUST00000034413.6
Vstm5
V-set and transmembrane domain containing 5
chr6_-_113377376 0.190 ENSMUST00000043333.2
Tada3
transcriptional adaptor 3
chr4_-_155086271 0.182 ENSMUST00000030914.3
Rer1
RER1 retention in endoplasmic reticulum 1 homolog (S. cerevisiae)
chr2_-_25546872 0.181 ENSMUST00000114234.1
ENSMUST00000028311.6
Traf2

TNF receptor-associated factor 2

chr2_-_30205772 0.151 ENSMUST00000113662.1
Ccbl1
cysteine conjugate-beta lyase 1
chr4_+_108834601 0.150 ENSMUST00000030296.8
Txndc12
thioredoxin domain containing 12 (endoplasmic reticulum)
chr2_+_149830840 0.126 ENSMUST00000109934.1
ENSMUST00000140870.1
Syndig1

synapse differentiation inducing 1

chr2_+_149830788 0.106 ENSMUST00000109935.1
Syndig1
synapse differentiation inducing 1
chr1_-_192855723 0.069 ENSMUST00000155579.1
Sertad4
SERTA domain containing 4
chr2_-_30205794 0.063 ENSMUST00000113663.2
ENSMUST00000044038.3
Ccbl1

cysteine conjugate-beta lyase 1

chr2_+_149830894 0.038 ENSMUST00000137280.1
ENSMUST00000149705.1
Syndig1

synapse differentiation inducing 1

chr5_-_86676346 0.025 ENSMUST00000038448.6
Tmprss11bnl
transmembrane protease, serine 11b N terminal like
chr5_+_130029277 0.025 ENSMUST00000026608.7
Crcp
calcitonin gene-related peptide-receptor component protein
chr17_+_29268788 0.018 ENSMUST00000064709.5
ENSMUST00000120346.1
BC004004

cDNA sequence BC004004

chr17_+_56005672 0.004 ENSMUST00000133998.1
Mpnd
MPN domain containing

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.2 0.7 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.2 1.6 GO:0090527 actin filament reorganization(GO:0090527)
0.1 0.4 GO:0071211 protein targeting to vacuole involved in autophagy(GO:0071211)
0.1 0.7 GO:0046490 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate metabolic process(GO:0046490)
0.1 0.8 GO:0032782 bile acid secretion(GO:0032782) positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.1 0.6 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.1 0.4 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.1 1.1 GO:0050965 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.1 0.4 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.0 0.2 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.0 0.6 GO:0051639 actin filament network formation(GO:0051639)
0.0 1.6 GO:0006270 DNA replication initiation(GO:0006270)
0.0 0.5 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.5 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.2 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 0.2 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.0 0.5 GO:0001706 endoderm formation(GO:0001706)
0.0 0.3 GO:0097091 synaptic vesicle clustering(GO:0097091)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0031088 platelet dense granule membrane(GO:0031088) intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637)
0.1 0.8 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 0.2 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.1 0.8 GO:0005922 connexon complex(GO:0005922)
0.1 0.3 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.6 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 0.4 GO:0000124 SAGA complex(GO:0000124)
0.0 0.6 GO:0001891 phagocytic cup(GO:0001891)
0.0 1.7 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.8 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 1.6 GO:0005884 actin filament(GO:0005884)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.6 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.1 1.7 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.1 0.3 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.1 0.7 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 0.7 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 0.1 GO:0019153 protein-disulfide reductase (glutathione) activity(GO:0019153)
0.0 0.5 GO:0070064 proline-rich region binding(GO:0070064)
0.0 1.8 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 0.6 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 0.2 GO:0031996 thioesterase binding(GO:0031996)
0.0 0.4 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.5 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.5 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 0.7 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.2 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism
0.0 1.1 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.2 REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.6 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis