Motif ID: Zic2
Z-value: 0.592

Transcription factors associated with Zic2:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Zic2 | ENSMUSG00000061524.8 | Zic2 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Zic2 | mm10_v2_chr14_+_122475397_122475435 | 0.20 | 2.2e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 1.5 | GO:1903002 | regulation of lipid transport across blood brain barrier(GO:1903000) positive regulation of lipid transport across blood brain barrier(GO:1903002) |
0.4 | 2.2 | GO:1901731 | positive regulation of platelet aggregation(GO:1901731) |
0.3 | 0.9 | GO:0048496 | maintenance of organ identity(GO:0048496) |
0.3 | 2.7 | GO:0070874 | negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874) |
0.3 | 1.1 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
0.2 | 1.2 | GO:0007386 | compartment pattern specification(GO:0007386) |
0.2 | 0.7 | GO:0035574 | histone H4-K20 demethylation(GO:0035574) |
0.2 | 0.9 | GO:0061743 | motor learning(GO:0061743) |
0.2 | 0.6 | GO:0010814 | substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959) |
0.2 | 0.7 | GO:0042414 | epinephrine metabolic process(GO:0042414) |
0.2 | 0.9 | GO:0010273 | detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169) |
0.2 | 0.5 | GO:2000170 | positive regulation of peptidyl-cysteine S-nitrosylation(GO:2000170) |
0.2 | 0.5 | GO:0021759 | globus pallidus development(GO:0021759) |
0.1 | 0.4 | GO:0036118 | hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106) |
0.1 | 0.7 | GO:0021764 | amygdala development(GO:0021764) |
0.1 | 0.4 | GO:0030200 | heparan sulfate proteoglycan catabolic process(GO:0030200) |
0.1 | 0.4 | GO:1904809 | dense core granule localization(GO:0032253) cellular response to isoquinoline alkaloid(GO:0071317) dense core granule transport(GO:1901950) regulation of dense core granule transport(GO:1904809) positive regulation of dense core granule transport(GO:1904811) |
0.1 | 0.5 | GO:1902037 | proteasomal ubiquitin-independent protein catabolic process(GO:0010499) positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091) negative regulation of hematopoietic stem cell differentiation(GO:1902037) |
0.1 | 0.3 | GO:0045590 | negative regulation of regulatory T cell differentiation(GO:0045590) |
0.1 | 1.0 | GO:0015074 | DNA integration(GO:0015074) |
0.1 | 0.2 | GO:0035019 | somatic stem cell population maintenance(GO:0035019) |
0.1 | 0.4 | GO:0098968 | neurotransmitter receptor transport postsynaptic membrane to endosome(GO:0098968) |
0.1 | 1.1 | GO:0018095 | protein polyglutamylation(GO:0018095) |
0.1 | 0.3 | GO:0010838 | positive regulation of keratinocyte proliferation(GO:0010838) |
0.1 | 0.7 | GO:0032488 | Cdc42 protein signal transduction(GO:0032488) |
0.1 | 1.0 | GO:0043568 | positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568) |
0.1 | 1.0 | GO:0033314 | mitotic DNA replication checkpoint(GO:0033314) |
0.1 | 0.3 | GO:0097278 | transforming growth factor beta activation(GO:0036363) complement-dependent cytotoxicity(GO:0097278) |
0.1 | 1.5 | GO:0060159 | regulation of dopamine receptor signaling pathway(GO:0060159) |
0.1 | 0.7 | GO:0048251 | elastic fiber assembly(GO:0048251) |
0.1 | 0.9 | GO:1902166 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166) |
0.1 | 0.6 | GO:1990086 | lens fiber cell apoptotic process(GO:1990086) |
0.1 | 0.4 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
0.1 | 0.3 | GO:0010248 | B cell negative selection(GO:0002352) establishment or maintenance of transmembrane electrochemical gradient(GO:0010248) |
0.1 | 0.3 | GO:0045950 | negative regulation of mitotic recombination(GO:0045950) |
0.1 | 0.4 | GO:0006987 | activation of signaling protein activity involved in unfolded protein response(GO:0006987) |
0.1 | 0.4 | GO:1903998 | regulation of eating behavior(GO:1903998) |
0.1 | 0.7 | GO:0099550 | trans-synaptic signalling, modulating synaptic transmission(GO:0099550) |
0.1 | 0.2 | GO:0006931 | substrate-dependent cell migration, cell attachment to substrate(GO:0006931) transforming growth factor-beta secretion(GO:0038044) blood coagulation, fibrin clot formation(GO:0072378) |
0.1 | 1.4 | GO:0030574 | collagen catabolic process(GO:0030574) |
0.1 | 0.2 | GO:0097026 | dendritic cell dendrite assembly(GO:0097026) |
0.1 | 0.3 | GO:1904706 | regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579) negative regulation of vascular smooth muscle cell proliferation(GO:1904706) |
0.1 | 0.4 | GO:2000255 | negative regulation of male germ cell proliferation(GO:2000255) |
0.1 | 0.3 | GO:0046210 | nitrate catabolic process(GO:0043602) nitric oxide catabolic process(GO:0046210) cellular organohalogen metabolic process(GO:0090345) cellular organofluorine metabolic process(GO:0090346) |
0.1 | 0.2 | GO:0009814 | defense response, incompatible interaction(GO:0009814) |
0.1 | 0.2 | GO:0006657 | CDP-choline pathway(GO:0006657) |
0.1 | 0.3 | GO:0030576 | Cajal body organization(GO:0030576) |
0.1 | 0.5 | GO:0032534 | regulation of microvillus assembly(GO:0032534) |
0.1 | 0.2 | GO:0002184 | cytoplasmic translational termination(GO:0002184) |
0.1 | 1.4 | GO:0032060 | bleb assembly(GO:0032060) |
0.1 | 0.8 | GO:0046339 | diacylglycerol metabolic process(GO:0046339) |
0.1 | 1.0 | GO:0048681 | negative regulation of axon regeneration(GO:0048681) |
0.1 | 0.3 | GO:1903463 | regulation of mitotic cell cycle DNA replication(GO:1903463) |
0.1 | 0.3 | GO:1904694 | negative regulation of vascular smooth muscle contraction(GO:1904694) |
0.1 | 0.3 | GO:0060024 | rhythmic synaptic transmission(GO:0060024) |
0.1 | 0.3 | GO:0055091 | phospholipid homeostasis(GO:0055091) |
0.1 | 0.2 | GO:0019482 | beta-alanine metabolic process(GO:0019482) |
0.1 | 0.2 | GO:1904778 | regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778) |
0.1 | 0.2 | GO:0006601 | creatine biosynthetic process(GO:0006601) |
0.1 | 0.2 | GO:0070829 | heterochromatin maintenance(GO:0070829) |
0.1 | 0.4 | GO:0021830 | interneuron migration from the subpallium to the cortex(GO:0021830) |
0.1 | 0.3 | GO:0032483 | regulation of Rab protein signal transduction(GO:0032483) |
0.1 | 0.2 | GO:0002934 | desmosome organization(GO:0002934) |
0.1 | 0.3 | GO:0035405 | histone-threonine phosphorylation(GO:0035405) |
0.1 | 0.8 | GO:0051639 | actin filament network formation(GO:0051639) |
0.0 | 0.5 | GO:0051574 | positive regulation of histone H3-K9 methylation(GO:0051574) |
0.0 | 0.7 | GO:0015809 | arginine transport(GO:0015809) |
0.0 | 0.1 | GO:0002554 | serotonin secretion by platelet(GO:0002554) interleukin-3 production(GO:0032632) beta selection(GO:0043366) |
0.0 | 0.3 | GO:0061092 | regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092) |
0.0 | 0.5 | GO:0060539 | diaphragm development(GO:0060539) |
0.0 | 0.3 | GO:0046826 | negative regulation of protein export from nucleus(GO:0046826) |
0.0 | 0.3 | GO:0051775 | response to redox state(GO:0051775) |
0.0 | 0.9 | GO:0005980 | polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247) |
0.0 | 1.1 | GO:0006677 | glycosylceramide metabolic process(GO:0006677) |
0.0 | 0.8 | GO:0021521 | ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573) |
0.0 | 0.2 | GO:1904491 | protein localization to ciliary transition zone(GO:1904491) |
0.0 | 0.2 | GO:0000050 | urea cycle(GO:0000050) urea metabolic process(GO:0019627) |
0.0 | 0.4 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
0.0 | 0.1 | GO:2000224 | regulation of testosterone biosynthetic process(GO:2000224) |
0.0 | 0.2 | GO:0006868 | glutamine transport(GO:0006868) |
0.0 | 0.1 | GO:0007066 | female meiosis sister chromatid cohesion(GO:0007066) |
0.0 | 0.2 | GO:1902302 | regulation of potassium ion export(GO:1902302) |
0.0 | 0.1 | GO:0019355 | nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process(GO:0034627) 'de novo' NAD biosynthetic process from aspartate(GO:0034628) |
0.0 | 0.1 | GO:0043456 | regulation of pentose-phosphate shunt(GO:0043456) |
0.0 | 0.2 | GO:1903847 | regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849) |
0.0 | 0.1 | GO:2001222 | regulation of neuron migration(GO:2001222) |
0.0 | 0.2 | GO:0040031 | snRNA modification(GO:0040031) |
0.0 | 0.5 | GO:0042178 | xenobiotic catabolic process(GO:0042178) |
0.0 | 0.6 | GO:0042711 | maternal behavior(GO:0042711) |
0.0 | 0.5 | GO:2000353 | positive regulation of endothelial cell apoptotic process(GO:2000353) |
0.0 | 0.1 | GO:0006669 | sphinganine-1-phosphate biosynthetic process(GO:0006669) |
0.0 | 0.2 | GO:1900262 | regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264) |
0.0 | 0.3 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
0.0 | 0.2 | GO:1990481 | mRNA pseudouridine synthesis(GO:1990481) |
0.0 | 0.0 | GO:0015822 | ornithine transport(GO:0015822) |
0.0 | 0.1 | GO:0035622 | intrahepatic bile duct development(GO:0035622) |
0.0 | 0.1 | GO:0010898 | positive regulation of triglyceride catabolic process(GO:0010898) |
0.0 | 1.3 | GO:0051489 | regulation of filopodium assembly(GO:0051489) |
0.0 | 0.2 | GO:0021891 | olfactory bulb interneuron development(GO:0021891) |
0.0 | 0.1 | GO:0018298 | protein-chromophore linkage(GO:0018298) |
0.0 | 0.7 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
0.0 | 0.2 | GO:0006013 | mannose metabolic process(GO:0006013) |
0.0 | 0.1 | GO:0045085 | negative regulation of interleukin-2 biosynthetic process(GO:0045085) |
0.0 | 0.3 | GO:0071712 | ER-associated misfolded protein catabolic process(GO:0071712) |
0.0 | 0.1 | GO:0098928 | presynaptic signal transduction(GO:0098928) presynapse to nucleus signaling pathway(GO:0099526) |
0.0 | 0.2 | GO:0003062 | regulation of heart rate by chemical signal(GO:0003062) |
0.0 | 0.2 | GO:0010820 | positive regulation of T cell chemotaxis(GO:0010820) |
0.0 | 0.6 | GO:2000249 | regulation of actin cytoskeleton reorganization(GO:2000249) |
0.0 | 0.8 | GO:0016601 | Rac protein signal transduction(GO:0016601) |
0.0 | 0.3 | GO:0045324 | late endosome to vacuole transport(GO:0045324) |
0.0 | 0.0 | GO:0002901 | mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906) |
0.0 | 0.2 | GO:0035459 | cargo loading into vesicle(GO:0035459) cargo loading into COPII-coated vesicle(GO:0090110) |
0.0 | 0.1 | GO:0048563 | post-embryonic organ morphogenesis(GO:0048563) |
0.0 | 0.1 | GO:2000409 | positive regulation of T cell extravasation(GO:2000409) |
0.0 | 0.1 | GO:0046959 | habituation(GO:0046959) |
0.0 | 0.3 | GO:0046597 | negative regulation of viral entry into host cell(GO:0046597) |
0.0 | 0.5 | GO:0014046 | dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059) |
0.0 | 0.6 | GO:0050873 | brown fat cell differentiation(GO:0050873) |
0.0 | 0.5 | GO:0046827 | positive regulation of protein export from nucleus(GO:0046827) |
0.0 | 0.5 | GO:0060445 | branching involved in salivary gland morphogenesis(GO:0060445) |
0.0 | 0.2 | GO:0032331 | negative regulation of chondrocyte differentiation(GO:0032331) |
0.0 | 0.2 | GO:0021819 | layer formation in cerebral cortex(GO:0021819) |
0.0 | 0.5 | GO:0061003 | positive regulation of dendritic spine morphogenesis(GO:0061003) |
0.0 | 0.9 | GO:0002066 | columnar/cuboidal epithelial cell development(GO:0002066) |
0.0 | 0.1 | GO:0046501 | protoporphyrinogen IX metabolic process(GO:0046501) |
0.0 | 0.2 | GO:0006516 | glycoprotein catabolic process(GO:0006516) |
0.0 | 0.3 | GO:0045540 | regulation of cholesterol biosynthetic process(GO:0045540) |
0.0 | 0.3 | GO:1902043 | positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043) |
0.0 | 0.5 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
0.0 | 0.1 | GO:0006654 | phosphatidic acid biosynthetic process(GO:0006654) |
0.0 | 0.1 | GO:0002322 | B cell proliferation involved in immune response(GO:0002322) |
0.0 | 0.3 | GO:0031571 | mitotic G1 DNA damage checkpoint(GO:0031571) |
0.0 | 0.1 | GO:0009404 | toxin metabolic process(GO:0009404) |
0.0 | 0.2 | GO:0045947 | negative regulation of translational initiation(GO:0045947) |
0.0 | 0.1 | GO:0044829 | positive regulation by host of viral genome replication(GO:0044829) |
0.0 | 0.1 | GO:0034315 | regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315) |
0.0 | 0.4 | GO:0018345 | protein palmitoylation(GO:0018345) |
0.0 | 0.2 | GO:0031937 | positive regulation of chromatin silencing(GO:0031937) |
0.0 | 0.2 | GO:0035024 | negative regulation of Rho protein signal transduction(GO:0035024) |
0.0 | 0.1 | GO:0000712 | resolution of meiotic recombination intermediates(GO:0000712) |
0.0 | 0.1 | GO:0006777 | Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) |
0.0 | 0.1 | GO:0033234 | negative regulation of protein sumoylation(GO:0033234) |
0.0 | 0.0 | GO:0035754 | B cell chemotaxis(GO:0035754) |
0.0 | 0.1 | GO:1901165 | positive regulation of trophoblast cell migration(GO:1901165) |
0.0 | 0.0 | GO:1902261 | positive regulation of delayed rectifier potassium channel activity(GO:1902261) |
0.0 | 0.2 | GO:0045943 | positive regulation of transcription from RNA polymerase I promoter(GO:0045943) |
0.0 | 0.1 | GO:0006265 | DNA topological change(GO:0006265) |
0.0 | 0.2 | GO:0034472 | snRNA 3'-end processing(GO:0034472) |
0.0 | 0.4 | GO:0000027 | ribosomal large subunit assembly(GO:0000027) |
0.0 | 0.1 | GO:0035336 | long-chain fatty-acyl-CoA metabolic process(GO:0035336) |
0.0 | 0.1 | GO:0035188 | blastocyst hatching(GO:0001835) hatching(GO:0035188) organism emergence from protective structure(GO:0071684) |
0.0 | 0.2 | GO:0006895 | Golgi to endosome transport(GO:0006895) |
0.0 | 0.0 | GO:0006409 | tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431) |
0.0 | 0.0 | GO:0010726 | positive regulation of hydrogen peroxide metabolic process(GO:0010726) |
0.0 | 0.8 | GO:0046785 | microtubule polymerization(GO:0046785) |
0.0 | 0.1 | GO:0051012 | microtubule sliding(GO:0051012) negative regulation of nonmotile primary cilium assembly(GO:1902856) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 1.5 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
0.3 | 0.9 | GO:0097543 | ciliary inversin compartment(GO:0097543) |
0.2 | 2.2 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
0.2 | 0.7 | GO:0045009 | melanosome membrane(GO:0033162) chitosome(GO:0045009) |
0.2 | 0.6 | GO:0097233 | lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233) |
0.2 | 0.8 | GO:0032127 | dense core granule membrane(GO:0032127) |
0.2 | 0.6 | GO:0005940 | septin ring(GO:0005940) |
0.2 | 0.7 | GO:1902937 | inward rectifier potassium channel complex(GO:1902937) |
0.2 | 0.9 | GO:0044301 | climbing fiber(GO:0044301) |
0.1 | 0.4 | GO:1990597 | AIP1-IRE1 complex(GO:1990597) |
0.1 | 0.6 | GO:0033093 | Weibel-Palade body(GO:0033093) |
0.1 | 1.0 | GO:0097427 | microtubule bundle(GO:0097427) |
0.1 | 0.3 | GO:0034272 | phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272) |
0.1 | 0.2 | GO:0071953 | fibrinogen complex(GO:0005577) elastic fiber(GO:0071953) |
0.1 | 0.2 | GO:0036488 | CHOP-C/EBP complex(GO:0036488) |
0.1 | 0.2 | GO:0018444 | translation release factor complex(GO:0018444) |
0.1 | 0.2 | GO:0032311 | angiogenin-PRI complex(GO:0032311) |
0.1 | 0.3 | GO:0034751 | aryl hydrocarbon receptor complex(GO:0034751) |
0.1 | 0.7 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
0.1 | 0.1 | GO:0098554 | cytoplasmic side of endoplasmic reticulum membrane(GO:0098554) |
0.0 | 0.2 | GO:0048476 | Holliday junction resolvase complex(GO:0048476) |
0.0 | 0.3 | GO:0070531 | BRCA1-A complex(GO:0070531) |
0.0 | 0.4 | GO:0034750 | Scrib-APC-beta-catenin complex(GO:0034750) |
0.0 | 0.1 | GO:0043541 | UDP-N-acetylglucosamine transferase complex(GO:0043541) |
0.0 | 0.9 | GO:0043218 | compact myelin(GO:0043218) |
0.0 | 1.3 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
0.0 | 0.5 | GO:0031528 | microvillus membrane(GO:0031528) |
0.0 | 0.3 | GO:0032591 | dendritic spine membrane(GO:0032591) |
0.0 | 0.5 | GO:0043083 | synaptic cleft(GO:0043083) |
0.0 | 0.1 | GO:0030132 | clathrin coat of coated pit(GO:0030132) |
0.0 | 1.3 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
0.0 | 0.2 | GO:0031390 | Ctf18 RFC-like complex(GO:0031390) |
0.0 | 0.1 | GO:0032021 | NELF complex(GO:0032021) |
0.0 | 0.2 | GO:0042587 | glycogen granule(GO:0042587) |
0.0 | 0.1 | GO:0002139 | stereocilia coupling link(GO:0002139) |
0.0 | 0.3 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
0.0 | 0.3 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) |
0.0 | 0.1 | GO:0005916 | fascia adherens(GO:0005916) |
0.0 | 0.1 | GO:1990257 | piccolo-bassoon transport vesicle(GO:1990257) |
0.0 | 0.1 | GO:0048179 | activin receptor complex(GO:0048179) |
0.0 | 0.5 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
0.0 | 0.3 | GO:0042555 | MCM complex(GO:0042555) |
0.0 | 0.2 | GO:0036038 | MKS complex(GO:0036038) |
0.0 | 0.4 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
0.0 | 0.1 | GO:0032009 | early phagosome(GO:0032009) |
0.0 | 0.6 | GO:0048786 | presynaptic active zone(GO:0048786) |
0.0 | 0.2 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
0.0 | 0.2 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
0.0 | 0.3 | GO:0030673 | axolemma(GO:0030673) |
0.0 | 0.7 | GO:0016459 | myosin complex(GO:0016459) |
0.0 | 0.2 | GO:0030127 | COPII vesicle coat(GO:0030127) |
0.0 | 0.1 | GO:0032421 | stereocilium(GO:0032420) stereocilium bundle(GO:0032421) |
0.0 | 2.9 | GO:0000139 | Golgi membrane(GO:0000139) |
0.0 | 0.3 | GO:0030665 | clathrin-coated vesicle membrane(GO:0030665) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 1.5 | GO:0046911 | hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
0.4 | 1.2 | GO:0033829 | O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829) |
0.3 | 1.0 | GO:0030158 | protein xylosyltransferase activity(GO:0030158) |
0.2 | 0.7 | GO:0035575 | histone demethylase activity (H4-K20 specific)(GO:0035575) |
0.2 | 0.7 | GO:0030368 | interleukin-17 receptor activity(GO:0030368) |
0.2 | 2.2 | GO:0015250 | water channel activity(GO:0015250) |
0.2 | 1.1 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
0.2 | 1.1 | GO:0001665 | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665) |
0.1 | 0.4 | GO:0050501 | hyaluronan synthase activity(GO:0050501) |
0.1 | 0.7 | GO:0035240 | dopamine binding(GO:0035240) |
0.1 | 0.7 | GO:0005030 | neurotrophin receptor activity(GO:0005030) |
0.1 | 1.1 | GO:0070739 | protein-glutamic acid ligase activity(GO:0070739) |
0.1 | 0.4 | GO:0036132 | 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522) |
0.1 | 0.4 | GO:2001069 | glycogen binding(GO:2001069) |
0.1 | 0.6 | GO:0010997 | anaphase-promoting complex binding(GO:0010997) |
0.1 | 0.4 | GO:0008184 | glycogen phosphorylase activity(GO:0008184) |
0.1 | 0.4 | GO:0004667 | prostaglandin-D synthase activity(GO:0004667) |
0.1 | 1.3 | GO:0005225 | volume-sensitive anion channel activity(GO:0005225) |
0.1 | 0.3 | GO:0070140 | isopeptidase activity(GO:0070122) ubiquitin-like protein-specific isopeptidase activity(GO:0070138) SUMO-specific isopeptidase activity(GO:0070140) |
0.1 | 0.4 | GO:0043208 | glycosphingolipid binding(GO:0043208) |
0.1 | 0.7 | GO:0015181 | arginine transmembrane transporter activity(GO:0015181) |
0.1 | 0.2 | GO:0004489 | methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489) |
0.1 | 0.2 | GO:0003987 | acetate-CoA ligase activity(GO:0003987) |
0.1 | 0.4 | GO:0010385 | double-stranded methylated DNA binding(GO:0010385) |
0.1 | 0.2 | GO:0004022 | alcohol dehydrogenase (NAD) activity(GO:0004022) |
0.1 | 0.3 | GO:0016708 | nitric oxide dioxygenase activity(GO:0008941) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor(GO:0016708) iron-cytochrome-c reductase activity(GO:0047726) |
0.1 | 2.7 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
0.1 | 0.6 | GO:0035251 | UDP-glucosyltransferase activity(GO:0035251) |
0.1 | 0.3 | GO:0046920 | alpha-(1->3)-fucosyltransferase activity(GO:0046920) |
0.1 | 0.1 | GO:0001729 | ceramide kinase activity(GO:0001729) |
0.1 | 0.1 | GO:0004645 | phosphorylase activity(GO:0004645) |
0.1 | 0.7 | GO:0005522 | profilin binding(GO:0005522) |
0.1 | 0.5 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
0.1 | 0.3 | GO:0030284 | estrogen receptor activity(GO:0030284) |
0.1 | 0.6 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
0.1 | 0.4 | GO:0070290 | N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290) |
0.1 | 0.5 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
0.0 | 0.3 | GO:0002135 | CTP binding(GO:0002135) |
0.0 | 0.2 | GO:0032422 | purine-rich negative regulatory element binding(GO:0032422) |
0.0 | 0.2 | GO:0070051 | fibrinogen binding(GO:0070051) |
0.0 | 0.1 | GO:0035402 | histone kinase activity (H3-T11 specific)(GO:0035402) |
0.0 | 0.2 | GO:0004105 | choline-phosphate cytidylyltransferase activity(GO:0004105) |
0.0 | 0.2 | GO:0004768 | stearoyl-CoA 9-desaturase activity(GO:0004768) |
0.0 | 0.2 | GO:1902282 | voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282) |
0.0 | 0.1 | GO:0035184 | histone threonine kinase activity(GO:0035184) |
0.0 | 0.7 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
0.0 | 0.5 | GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) |
0.0 | 0.2 | GO:0015186 | L-glutamine transmembrane transporter activity(GO:0015186) |
0.0 | 0.1 | GO:0004515 | nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515) |
0.0 | 0.1 | GO:0046538 | bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538) |
0.0 | 1.5 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
0.0 | 0.6 | GO:0017166 | vinculin binding(GO:0017166) |
0.0 | 0.2 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
0.0 | 0.3 | GO:0050431 | transforming growth factor beta binding(GO:0050431) |
0.0 | 0.2 | GO:0004043 | L-aminoadipate-semialdehyde dehydrogenase activity(GO:0004043) |
0.0 | 0.1 | GO:0004574 | oligo-1,6-glucosidase activity(GO:0004574) |
0.0 | 0.2 | GO:0008821 | crossover junction endodeoxyribonuclease activity(GO:0008821) |
0.0 | 0.4 | GO:0008484 | sulfuric ester hydrolase activity(GO:0008484) |
0.0 | 0.1 | GO:0004686 | elongation factor-2 kinase activity(GO:0004686) |
0.0 | 0.1 | GO:0052658 | inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) |
0.0 | 0.1 | GO:0004692 | cGMP-dependent protein kinase activity(GO:0004692) |
0.0 | 0.5 | GO:0070402 | NADPH binding(GO:0070402) |
0.0 | 0.4 | GO:0015923 | mannosidase activity(GO:0015923) |
0.0 | 0.2 | GO:0003747 | translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079) |
0.0 | 0.1 | GO:0008113 | peptide-methionine (S)-S-oxide reductase activity(GO:0008113) |
0.0 | 0.0 | GO:0000064 | L-ornithine transmembrane transporter activity(GO:0000064) |
0.0 | 0.4 | GO:0005161 | platelet-derived growth factor receptor binding(GO:0005161) |
0.0 | 0.2 | GO:0000182 | rDNA binding(GO:0000182) |
0.0 | 0.2 | GO:0003689 | DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) |
0.0 | 0.1 | GO:0017050 | sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050) |
0.0 | 0.1 | GO:0009881 | photoreceptor activity(GO:0009881) |
0.0 | 0.3 | GO:0001968 | fibronectin binding(GO:0001968) |
0.0 | 0.2 | GO:0097371 | MDM2/MDM4 family protein binding(GO:0097371) |
0.0 | 0.1 | GO:0004716 | receptor signaling protein tyrosine kinase activity(GO:0004716) |
0.0 | 0.1 | GO:0004534 | 5'-3' exoribonuclease activity(GO:0004534) |
0.0 | 0.1 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) |
0.0 | 0.2 | GO:0008420 | CTD phosphatase activity(GO:0008420) |
0.0 | 0.2 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
0.0 | 0.5 | GO:0050840 | extracellular matrix binding(GO:0050840) |
0.0 | 0.2 | GO:0015299 | solute:proton antiporter activity(GO:0015299) |
0.0 | 0.3 | GO:0051400 | BH domain binding(GO:0051400) |
0.0 | 0.5 | GO:0030371 | translation repressor activity(GO:0030371) |
0.0 | 0.2 | GO:0045499 | chemorepellent activity(GO:0045499) |
0.0 | 0.1 | GO:0016004 | phospholipase activator activity(GO:0016004) lipase activator activity(GO:0060229) |
0.0 | 0.4 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
0.0 | 0.9 | GO:0030507 | spectrin binding(GO:0030507) |
0.0 | 0.2 | GO:0001013 | RNA polymerase I regulatory region DNA binding(GO:0001013) |
0.0 | 0.7 | GO:0005507 | copper ion binding(GO:0005507) |
0.0 | 0.4 | GO:0004385 | guanylate kinase activity(GO:0004385) |
0.0 | 0.5 | GO:0050998 | nitric-oxide synthase binding(GO:0050998) |
0.0 | 0.1 | GO:0016361 | activin receptor activity, type I(GO:0016361) |
0.0 | 0.4 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
0.0 | 1.0 | GO:0005518 | collagen binding(GO:0005518) |
0.0 | 0.1 | GO:0035877 | death effector domain binding(GO:0035877) |
0.0 | 0.1 | GO:2001070 | starch binding(GO:2001070) |
0.0 | 0.2 | GO:0005328 | neurotransmitter:sodium symporter activity(GO:0005328) |
0.0 | 0.4 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
0.0 | 0.5 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
0.0 | 0.3 | GO:0019905 | syntaxin binding(GO:0019905) |
0.0 | 0.5 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
0.0 | 0.2 | GO:0001056 | RNA polymerase III activity(GO:0001056) |
0.0 | 1.1 | GO:0033613 | activating transcription factor binding(GO:0033613) |
0.0 | 0.0 | GO:0038085 | vascular endothelial growth factor binding(GO:0038085) |
0.0 | 0.2 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
0.0 | 0.1 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 3.0 | PID_RET_PATHWAY | Signaling events regulated by Ret tyrosine kinase |
0.0 | 0.6 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
0.0 | 1.5 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
0.0 | 1.1 | PID_INSULIN_GLUCOSE_PATHWAY | Insulin-mediated glucose transport |
0.0 | 0.7 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
0.0 | 0.4 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
0.0 | 0.8 | PID_SYNDECAN_4_PATHWAY | Syndecan-4-mediated signaling events |
0.0 | 0.8 | PID_A6B1_A6B4_INTEGRIN_PATHWAY | a6b1 and a6b4 Integrin signaling |
0.0 | 0.5 | PID_HIF1A_PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
0.0 | 0.3 | PID_SYNDECAN_2_PATHWAY | Syndecan-2-mediated signaling events |
0.0 | 0.5 | SA_CASPASE_CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
0.0 | 1.7 | PID_ERA_GENOMIC_PATHWAY | Validated nuclear estrogen receptor alpha network |
0.0 | 0.8 | PID_CERAMIDE_PATHWAY | Ceramide signaling pathway |
0.0 | 0.8 | PID_FGF_PATHWAY | FGF signaling pathway |
0.0 | 0.3 | SA_PROGRAMMED_CELL_DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
0.0 | 0.1 | PID_TCR_JNK_PATHWAY | JNK signaling in the CD4+ TCR pathway |
0.0 | 0.7 | PID_AJDISS_2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
0.0 | 2.3 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
0.0 | 0.6 | PID_ATR_PATHWAY | ATR signaling pathway |
0.0 | 0.2 | PID_PRL_SIGNALING_EVENTS_PATHWAY | Signaling events mediated by PRL |
0.0 | 0.3 | PID_FOXM1_PATHWAY | FOXM1 transcription factor network |
0.0 | 0.1 | PID_AVB3_OPN_PATHWAY | Osteopontin-mediated events |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 2.7 | REACTOME_SIGNAL_ATTENUATION | Genes involved in Signal attenuation |
0.1 | 1.5 | REACTOME_HDL_MEDIATED_LIPID_TRANSPORT | Genes involved in HDL-mediated lipid transport |
0.1 | 1.0 | REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
0.1 | 0.7 | REACTOME_AMINE_DERIVED_HORMONES | Genes involved in Amine-derived hormones |
0.1 | 1.1 | REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
0.1 | 0.6 | REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING | Genes involved in Role of second messengers in netrin-1 signaling |
0.1 | 0.6 | REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
0.0 | 0.4 | REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
0.0 | 0.3 | REACTOME_THE_NLRP3_INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
0.0 | 2.2 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
0.0 | 0.5 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
0.0 | 0.6 | REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
0.0 | 0.8 | REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
0.0 | 0.3 | REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
0.0 | 0.3 | REACTOME_CALNEXIN_CALRETICULIN_CYCLE | Genes involved in Calnexin/calreticulin cycle |
0.0 | 0.2 | REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
0.0 | 0.4 | REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
0.0 | 0.4 | REACTOME_HS_GAG_DEGRADATION | Genes involved in HS-GAG degradation |
0.0 | 0.4 | REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
0.0 | 0.9 | REACTOME_NETRIN1_SIGNALING | Genes involved in Netrin-1 signaling |
0.0 | 0.6 | REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
0.0 | 0.3 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
0.0 | 0.3 | REACTOME_UNWINDING_OF_DNA | Genes involved in Unwinding of DNA |
0.0 | 0.4 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
0.0 | 0.2 | REACTOME_ACTIVATION_OF_NF_KAPPAB_IN_B_CELLS | Genes involved in Activation of NF-kappaB in B Cells |
0.0 | 0.2 | REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
0.0 | 0.3 | REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
0.0 | 0.6 | REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE | Genes involved in NGF signalling via TRKA from the plasma membrane |
0.0 | 0.2 | REACTOME_SYNTHESIS_OF_PC | Genes involved in Synthesis of PC |
0.0 | 0.2 | REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
0.0 | 0.3 | REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING | Genes involved in Integrin alphaIIb beta3 signaling |
0.0 | 0.2 | REACTOME_ABORTIVE_ELONGATION_OF_HIV1_TRANSCRIPT_IN_THE_ABSENCE_OF_TAT | Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat |
0.0 | 0.4 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |