Motif ID: Pou3f2

Z-value: 0.662


Transcription factors associated with Pou3f2:

Gene SymbolEntrez IDGene Name
Pou3f2 ENSMUSG00000095139.1 Pou3f2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pou3f2mm10_v2_chr4_-_22488296_224883660.251.1e-01Click!


Activity profile for motif Pou3f2.

activity profile for motif Pou3f2


Sorted Z-values histogram for motif Pou3f2

Sorted Z-values for motif Pou3f2



Network of associatons between targets according to the STRING database.



First level regulatory network of Pou3f2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_-_103843685 2.860 ENSMUST00000172237.1
Ednrb
endothelin receptor type B
chr14_-_103844173 2.834 ENSMUST00000022718.3
Ednrb
endothelin receptor type B
chr11_+_23256566 2.170 ENSMUST00000136235.1
Xpo1
exportin 1, CRM1 homolog (yeast)
chr3_+_141465564 1.874 ENSMUST00000106236.2
ENSMUST00000075282.3
Unc5c

unc-5 homolog C (C. elegans)

chr18_+_5593566 1.839 ENSMUST00000160910.1
Zeb1
zinc finger E-box binding homeobox 1
chr14_-_47418407 1.578 ENSMUST00000043296.3
Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr18_+_4920509 1.422 ENSMUST00000126977.1
Svil
supervillin
chr6_+_90465287 1.344 ENSMUST00000113530.1
Klf15
Kruppel-like factor 15
chr14_+_99046406 1.321 ENSMUST00000022656.6
Bora
bora, aurora kinase A activator
chr17_-_46032366 1.262 ENSMUST00000071648.5
ENSMUST00000142351.2
ENSMUST00000167860.1
Vegfa


vascular endothelial growth factor A


chr3_+_88965812 1.131 ENSMUST00000090933.4
Ash1l
ash1 (absent, small, or homeotic)-like (Drosophila)
chr4_-_110286581 1.105 ENSMUST00000138972.1
Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chrX_-_162159717 1.091 ENSMUST00000087085.3
Nhs
Nance-Horan syndrome (human)
chr17_-_46031813 1.081 ENSMUST00000024747.7
Vegfa
vascular endothelial growth factor A
chr18_-_74961252 1.045 ENSMUST00000066532.4
Lipg
lipase, endothelial
chr3_+_141465592 0.998 ENSMUST00000130636.1
Unc5c
unc-5 homolog C (C. elegans)
chr7_+_75610038 0.926 ENSMUST00000125771.1
Akap13
A kinase (PRKA) anchor protein 13
chr9_+_44981779 0.917 ENSMUST00000034602.7
Cd3d
CD3 antigen, delta polypeptide
chr1_+_74661794 0.883 ENSMUST00000129890.1
Ttll4
tubulin tyrosine ligase-like family, member 4
chr3_-_36571952 0.877 ENSMUST00000029270.3
Ccna2
cyclin A2
chr12_-_91384403 0.856 ENSMUST00000141429.1
Cep128
centrosomal protein 128
chr1_+_150392794 0.848 ENSMUST00000124973.2
Tpr
translocated promoter region
chr1_-_139377094 0.841 ENSMUST00000131586.1
ENSMUST00000145244.1
Crb1

crumbs homolog 1 (Drosophila)

chr2_-_60125651 0.831 ENSMUST00000112550.1
Baz2b
bromodomain adjacent to zinc finger domain, 2B
chr19_+_38930909 0.820 ENSMUST00000025965.5
Hells
helicase, lymphoid specific
chr19_+_60144682 0.779 ENSMUST00000065383.4
E330013P04Rik
RIKEN cDNA E330013P04 gene
chr16_+_36875119 0.756 ENSMUST00000135406.1
ENSMUST00000114812.1
ENSMUST00000134616.1
ENSMUST00000023534.6
Golgb1


Golgb1
golgi autoantigen, golgin subfamily b, macrogolgin 1


golgi autoantigen, golgin subfamily b, macrogolgin 1
chr4_-_109665249 0.723 ENSMUST00000063531.4
Cdkn2c
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr11_-_82829024 0.704 ENSMUST00000021036.6
ENSMUST00000074515.4
ENSMUST00000103218.2
Rffl


ring finger and FYVE like domain containing protein


chr1_+_74661714 0.694 ENSMUST00000042125.8
ENSMUST00000141119.1
Ttll4

tubulin tyrosine ligase-like family, member 4

chr7_+_51621830 0.694 ENSMUST00000032710.5
Slc17a6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr14_+_84443553 0.692 ENSMUST00000071370.5
Pcdh17
protocadherin 17
chr12_+_52699297 0.684 ENSMUST00000095737.3
Akap6
A kinase (PRKA) anchor protein 6
chr5_+_107497762 0.624 ENSMUST00000152474.1
ENSMUST00000060553.7
A830010M20Rik

RIKEN cDNA A830010M20 gene

chr15_+_36179530 0.598 ENSMUST00000171205.1
Spag1
sperm associated antigen 1
chrX_-_145505175 0.596 ENSMUST00000143610.1
Amot
angiomotin
chr6_-_23248264 0.576 ENSMUST00000031709.5
Fezf1
Fez family zinc finger 1
chr16_-_36784784 0.575 ENSMUST00000165531.1
Slc15a2
solute carrier family 15 (H+/peptide transporter), member 2
chr7_-_140822124 0.567 ENSMUST00000106052.1
ENSMUST00000080651.6
Zfp941

zinc finger protein 941

chr3_+_27984145 0.540 ENSMUST00000067757.4
Pld1
phospholipase D1
chr10_-_53630439 0.526 ENSMUST00000075540.5
Mcm9
minichromosome maintenance complex component 9
chr11_+_23256001 0.483 ENSMUST00000020538.6
ENSMUST00000109551.1
ENSMUST00000102870.1
ENSMUST00000102869.1
Xpo1



exportin 1, CRM1 homolog (yeast)



chr16_+_44867097 0.469 ENSMUST00000102805.3
Cd200r2
Cd200 receptor 2
chr1_-_150392719 0.445 ENSMUST00000006167.6
ENSMUST00000094477.2
ENSMUST00000097547.3
BC003331


cDNA sequence BC003331


chr3_-_51560816 0.433 ENSMUST00000037141.7
Setd7
SET domain containing (lysine methyltransferase) 7
chr5_+_14025305 0.430 ENSMUST00000073957.6
Sema3e
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr9_+_88581036 0.427 ENSMUST00000164661.2
Trim43a
tripartite motif-containing 43A
chr1_-_172206684 0.415 ENSMUST00000155109.1
Pea15a
phosphoprotein enriched in astrocytes 15A
chr13_+_44840686 0.401 ENSMUST00000173906.1
Jarid2
jumonji, AT rich interactive domain 2
chr1_-_172206775 0.389 ENSMUST00000013842.5
ENSMUST00000111247.1
Pea15a

phosphoprotein enriched in astrocytes 15A

chr2_+_65930117 0.387 ENSMUST00000176109.1
Csrnp3
cysteine-serine-rich nuclear protein 3
chr14_-_16575456 0.382 ENSMUST00000063750.6
Rarb
retinoic acid receptor, beta
chr9_+_88839164 0.379 ENSMUST00000163255.2
Trim43c
tripartite motif-containing 43C
chr2_+_80315461 0.377 ENSMUST00000028392.7
Dnajc10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr6_+_34384218 0.374 ENSMUST00000038383.7
ENSMUST00000115051.1
Akr1b10

aldo-keto reductase family 1, member B10 (aldose reductase)

chr13_-_74376566 0.361 ENSMUST00000091481.2
Zfp72
zinc finger protein 72
chr9_-_89092835 0.359 ENSMUST00000167113.1
Trim43b
tripartite motif-containing 43B
chr17_-_6449571 0.352 ENSMUST00000180035.1
Tmem181b-ps
transmembrane protein 181B, pseudogene
chr2_+_61593077 0.345 ENSMUST00000112495.1
ENSMUST00000112501.2
Tank

TRAF family member-associated Nf-kappa B activator

chr5_+_86804508 0.345 ENSMUST00000038384.7
Ythdc1
YTH domain containing 1
chrX_+_96456362 0.341 ENSMUST00000079322.5
ENSMUST00000113838.1
Heph

hephaestin

chr18_-_43477764 0.340 ENSMUST00000057110.9
Eif3j2
eukaryotic translation initiation factor 3, subunit J2
chr7_+_16781341 0.338 ENSMUST00000108496.2
Slc1a5
solute carrier family 1 (neutral amino acid transporter), member 5
chr14_+_79515618 0.335 ENSMUST00000110835.1
Elf1
E74-like factor 1
chr11_-_50931612 0.323 ENSMUST00000109124.3
Zfp354b
zinc finger protein 354B
chr10_-_69352886 0.308 ENSMUST00000119827.1
ENSMUST00000020099.5
Cdk1

cyclin-dependent kinase 1

chr5_+_107497718 0.307 ENSMUST00000112671.2
A830010M20Rik
RIKEN cDNA A830010M20 gene
chr5_+_122284365 0.303 ENSMUST00000053426.8
Pptc7
PTC7 protein phosphatase homolog (S. cerevisiae)
chr7_-_133015248 0.294 ENSMUST00000169570.1
Ctbp2
C-terminal binding protein 2
chr9_-_105521147 0.282 ENSMUST00000176770.1
ENSMUST00000085133.6
Atp2c1

ATPase, Ca++-sequestering

chr12_-_31351368 0.277 ENSMUST00000110857.3
Dld
dihydrolipoamide dehydrogenase
chr3_+_66985947 0.270 ENSMUST00000161726.1
ENSMUST00000160504.1
Rsrc1

arginine/serine-rich coiled-coil 1

chr4_+_11758147 0.268 ENSMUST00000029871.5
ENSMUST00000108303.1
Cdh17

cadherin 17

chr12_+_71170589 0.252 ENSMUST00000129376.1
2700049A03Rik
RIKEN cDNA 2700049A03 gene
chr13_-_21468474 0.250 ENSMUST00000068235.4
Nkapl
NFKB activating protein-like
chr16_+_58670208 0.247 ENSMUST00000060077.5
Cpox
coproporphyrinogen oxidase
chr3_+_95929246 0.244 ENSMUST00000165307.1
ENSMUST00000015893.6
Anp32e

acidic (leucine-rich) nuclear phosphoprotein 32 family, member E

chr14_-_88471396 0.228 ENSMUST00000061628.5
Pcdh20
protocadherin 20
chr3_+_66985647 0.213 ENSMUST00000162362.1
ENSMUST00000065074.7
Rsrc1

arginine/serine-rich coiled-coil 1

chr16_-_17561240 0.209 ENSMUST00000065125.5
ENSMUST00000100123.3
ENSMUST00000023442.6
4930451C15Rik


RIKEN cDNA 4930451C15 gene


chr8_+_85432686 0.207 ENSMUST00000180883.1
1700051O22Rik
RIKEN cDNA 1700051O22 Gene
chr3_+_66985680 0.202 ENSMUST00000065047.6
Rsrc1
arginine/serine-rich coiled-coil 1
chr3_+_66985700 0.201 ENSMUST00000046542.6
ENSMUST00000162693.1
Rsrc1

arginine/serine-rich coiled-coil 1

chr17_+_71204647 0.201 ENSMUST00000126681.1
Lpin2
lipin 2
chrX_-_145505136 0.198 ENSMUST00000112835.1
Amot
angiomotin
chr6_+_8209216 0.195 ENSMUST00000040017.7
Mios
missing oocyte, meiosis regulator, homolog (Drosophila)
chr12_+_51377560 0.193 ENSMUST00000021335.5
Scfd1
Sec1 family domain containing 1
chr7_+_119690026 0.189 ENSMUST00000047045.8
Acsm4
acyl-CoA synthetase medium-chain family member 4
chr11_-_23519181 0.188 ENSMUST00000020527.5
1700093K21Rik
RIKEN cDNA 1700093K21 gene
chr2_+_65620829 0.186 ENSMUST00000028377.7
Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr16_-_36874806 0.178 ENSMUST00000075946.5
Eaf2
ELL associated factor 2
chr1_-_156036473 0.171 ENSMUST00000097527.3
ENSMUST00000027738.7
Tor1aip1

torsin A interacting protein 1

chr16_-_36784924 0.170 ENSMUST00000168279.1
ENSMUST00000164579.1
ENSMUST00000023616.2
Slc15a2


solute carrier family 15 (H+/peptide transporter), member 2


chr19_+_44203265 0.168 ENSMUST00000026220.5
Scd3
stearoyl-coenzyme A desaturase 3
chr3_+_95929325 0.156 ENSMUST00000171368.1
ENSMUST00000168106.1
Anp32e

acidic (leucine-rich) nuclear phosphoprotein 32 family, member E

chr15_-_83149270 0.153 ENSMUST00000129372.1
Poldip3
polymerase (DNA-directed), delta interacting protein 3
chr14_+_32166104 0.153 ENSMUST00000164341.1
Ncoa4
nuclear receptor coactivator 4
chr1_+_167618246 0.151 ENSMUST00000111380.1
Rxrg
retinoid X receptor gamma
chr3_+_88207308 0.140 ENSMUST00000180582.1
Gm3764
predicted gene 3764
chr15_-_81729864 0.132 ENSMUST00000171115.1
ENSMUST00000170134.1
ENSMUST00000052374.5
Rangap1


RAN GTPase activating protein 1


chr2_+_104590453 0.126 ENSMUST00000028599.7
Cstf3
cleavage stimulation factor, 3' pre-RNA, subunit 3
chr4_-_108780503 0.108 ENSMUST00000106658.1
Zfyve9
zinc finger, FYVE domain containing 9
chr1_-_52490736 0.096 ENSMUST00000170269.1
Nab1
Ngfi-A binding protein 1
chr3_-_157925056 0.093 ENSMUST00000118539.1
Cth
cystathionase (cystathionine gamma-lyase)
chr8_+_85171322 0.078 ENSMUST00000076896.5
Gm6531
predicted gene 6531
chrX_-_165004829 0.074 ENSMUST00000114890.2
Gm17604
predicted gene, 17604
chr10_+_56377300 0.072 ENSMUST00000068581.7
Gja1
gap junction protein, alpha 1
chr2_-_136387929 0.067 ENSMUST00000035264.2
ENSMUST00000077200.3
Pak7

p21 protein (Cdc42/Rac)-activated kinase 7

chr1_+_195017399 0.061 ENSMUST00000181273.1
A330023F24Rik
RIKEN cDNA A330023F24 gene
chr10_+_57794335 0.050 ENSMUST00000151623.1
ENSMUST00000020022.7
Smpdl3a

sphingomyelin phosphodiesterase, acid-like 3A

chrX_+_164419782 0.042 ENSMUST00000033754.7
Piga
phosphatidylinositol glycan anchor biosynthesis, class A
chr3_+_88206786 0.041 ENSMUST00000181134.1
ENSMUST00000181550.1
Gm3764

predicted gene 3764

chr13_-_110280103 0.039 ENSMUST00000167824.1
Rab3c
RAB3C, member RAS oncogene family
chr1_-_72212249 0.038 ENSMUST00000048860.7
Mreg
melanoregulin
chr4_-_108780782 0.037 ENSMUST00000106657.1
Zfyve9
zinc finger, FYVE domain containing 9
chr17_+_70561739 0.036 ENSMUST00000097288.2
Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr17_+_39846958 0.035 ENSMUST00000182010.1
Gm26924
predicted gene, 26924
chrX_-_95166307 0.034 ENSMUST00000113873.2
ENSMUST00000113876.2
ENSMUST00000113885.1
ENSMUST00000113883.1
ENSMUST00000182001.1
ENSMUST00000113882.1
ENSMUST00000113878.1
ENSMUST00000182562.1
Arhgef9







CDC42 guanine nucleotide exchange factor (GEF) 9







chr4_-_136835843 0.028 ENSMUST00000105846.2
ENSMUST00000059287.7
ENSMUST00000105845.2
Ephb2


Eph receptor B2


chr5_-_24527276 0.011 ENSMUST00000088311.4
Gbx1
gastrulation brain homeobox 1
chr11_-_98625661 0.005 ENSMUST00000104933.1
Gm12355
predicted gene 12355

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.7 GO:0014826 vein smooth muscle contraction(GO:0014826)
0.8 2.3 GO:1902336 neuropilin signaling pathway(GO:0038189) VEGF-activated neuropilin signaling pathway(GO:0038190) positive regulation of retinal ganglion cell axon guidance(GO:1902336)
0.4 2.9 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.3 2.7 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.3 0.8 GO:0032240 RNA import into nucleus(GO:0006404) mRNA export from nucleus in response to heat stress(GO:0031990) negative regulation of nucleobase-containing compound transport(GO:0032240) negative regulation of RNA export from nucleus(GO:0046832)
0.3 1.0 GO:0010986 positive regulation of lipoprotein particle clearance(GO:0010986)
0.2 1.8 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.2 0.8 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.2 0.7 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.2 1.6 GO:0018095 protein polyglutamylation(GO:0018095)
0.2 0.7 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.2 1.1 GO:0002674 negative regulation of acute inflammatory response(GO:0002674)
0.2 0.9 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.1 0.7 GO:0042891 antibiotic transport(GO:0042891) dipeptide transport(GO:0042938)
0.1 0.8 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
0.1 0.9 GO:0045059 positive thymic T cell selection(GO:0045059)
0.1 0.6 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 0.3 GO:0009106 lipoate metabolic process(GO:0009106)
0.1 0.3 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.1 0.3 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.1 0.3 GO:0015825 L-serine transport(GO:0015825)
0.1 0.5 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.1 0.7 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.1 1.3 GO:0072112 renal filtration cell differentiation(GO:0061318) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.1 0.3 GO:0055071 cellular manganese ion homeostasis(GO:0030026) Golgi calcium ion homeostasis(GO:0032468) manganese ion homeostasis(GO:0055071)
0.1 0.4 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.1 0.4 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.0 0.7 GO:2000807 regulation of synaptic vesicle clustering(GO:2000807)
0.0 0.2 GO:0046501 protoporphyrinogen IX metabolic process(GO:0046501)
0.0 0.4 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 0.4 GO:0044791 modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791)
0.0 0.2 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0 0.2 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.0 1.3 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.0 0.3 GO:0090166 Golgi disassembly(GO:0090166)
0.0 0.8 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.0 0.1 GO:0019343 cysteine biosynthetic process via cystathionine(GO:0019343) cysteine biosynthetic process(GO:0019344)
0.0 0.4 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.0 0.3 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 0.7 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.0 0.1 GO:0003104 positive regulation of glomerular filtration(GO:0003104) cell communication by chemical coupling(GO:0010643)
0.0 0.8 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 0.3 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.9 GO:0016572 histone phosphorylation(GO:0016572)
0.0 0.9 GO:0046677 response to antibiotic(GO:0046677)
0.0 0.4 GO:0043486 histone exchange(GO:0043486)
0.0 0.2 GO:0071763 nuclear membrane organization(GO:0071763)
0.0 0.2 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)
0.0 0.1 GO:0046826 negative regulation of protein export from nucleus(GO:0046826)
0.0 1.1 GO:0002088 lens development in camera-type eye(GO:0002088)
0.0 0.5 GO:0006270 DNA replication initiation(GO:0006270)
0.0 0.4 GO:2000249 regulation of actin cytoskeleton reorganization(GO:2000249)
0.0 1.1 GO:0043488 regulation of mRNA stability(GO:0043488)
0.0 0.1 GO:0006685 sphingomyelin catabolic process(GO:0006685)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.7 GO:0005642 annulate lamellae(GO:0005642)
0.2 0.9 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.2 0.8 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.1 1.3 GO:0072687 meiotic spindle(GO:0072687)
0.1 0.9 GO:0001940 male pronucleus(GO:0001940)
0.1 1.6 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 1.1 GO:0042788 polysomal ribosome(GO:0042788)
0.1 0.1 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.0 0.3 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.7 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.3 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.5 GO:0042555 MCM complex(GO:0042555)
0.0 1.4 GO:0043034 costamere(GO:0043034)
0.0 0.8 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 0.4 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.7 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 5.9 GO:0031965 nuclear membrane(GO:0031965)
0.0 2.3 GO:0005604 basement membrane(GO:0005604)
0.0 0.1 GO:0005916 fascia adherens(GO:0005916)
0.0 0.9 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.8 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.4 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.2 GO:0061700 GATOR2 complex(GO:0061700)
0.0 0.3 GO:0097470 ribbon synapse(GO:0097470)
0.0 0.9 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.8 GO:0005902 microvillus(GO:0005902)
0.0 1.1 GO:0005814 centriole(GO:0005814)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.7 GO:0004962 endothelin receptor activity(GO:0004962)
0.8 2.3 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.5 2.9 GO:0005042 netrin receptor activity(GO:0005042)
0.3 2.7 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.3 1.0 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.2 0.7 GO:0042936 dipeptide transporter activity(GO:0042936)
0.2 1.6 GO:0070739 protein-glutamic acid ligase activity(GO:0070739)
0.2 1.1 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.2 0.8 GO:0043532 angiostatin binding(GO:0043532)
0.1 0.3 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.1 0.9 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.3 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.1 0.4 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.1 0.3 GO:0015410 manganese-transporting ATPase activity(GO:0015410)
0.1 0.3 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 0.5 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.1 0.2 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 0.2 GO:0003996 acyl-CoA ligase activity(GO:0003996)
0.1 0.3 GO:0034604 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.1 0.7 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.7 GO:0043495 protein anchor(GO:0043495)
0.0 0.2 GO:0032896 palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.0 0.8 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 0.4 GO:0038191 neuropilin binding(GO:0038191)
0.0 1.8 GO:0070888 E-box binding(GO:0070888)
0.0 0.3 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.0 0.7 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.0 0.3 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 1.1 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.2 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.5 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.3 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 1.2 GO:0097472 cyclin-dependent protein kinase activity(GO:0097472)
0.0 0.4 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.0 0.1 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) gap junction channel activity involved in cell communication by electrical coupling(GO:1903763)
0.0 0.1 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.0 0.4 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 0.8 GO:0005080 protein kinase C binding(GO:0005080)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.3 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.2 2.8 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 5.8 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.1 0.9 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 2.9 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 1.8 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 1.6 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 0.3 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 1.3 PID_PLK1_PATHWAY PLK1 signaling events
0.0 1.0 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.0 0.8 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.9 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.0 1.5 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 0.5 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.7 PID_TNF_PATHWAY TNF receptor signaling pathway
0.0 0.3 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.8 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.2 2.3 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.2 0.9 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 5.3 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 2.9 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 1.6 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 0.8 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.8 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 0.3 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.3 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.7 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 0.2 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.0 0.4 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.5 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.0 0.3 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 1.0 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 0.2 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins