Motif ID: Zkscan3

Z-value: 0.463


Transcription factors associated with Zkscan3:

Gene SymbolEntrez IDGene Name
Zkscan3 ENSMUSG00000021327.12 Zkscan3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zkscan3mm10_v2_chr13_-_21402688_21402755-0.067.3e-01Click!


Activity profile for motif Zkscan3.

activity profile for motif Zkscan3


Sorted Z-values histogram for motif Zkscan3

Sorted Z-values for motif Zkscan3



Network of associatons between targets according to the STRING database.



First level regulatory network of Zkscan3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_75422586 1.470 ENSMUST00000138661.1
ENSMUST00000000769.7
Serpinf1

serine (or cysteine) peptidase inhibitor, clade F, member 1

chr4_+_156026120 1.317 ENSMUST00000103173.3
Tnfrsf18
tumor necrosis factor receptor superfamily, member 18
chr12_+_112588753 1.268 ENSMUST00000101029.2
Inf2
inverted formin, FH2 and WH2 domain containing
chr6_-_97459279 1.211 ENSMUST00000113359.1
Frmd4b
FERM domain containing 4B
chr1_-_173333503 1.064 ENSMUST00000038227.4
Darc
Duffy blood group, chemokine receptor
chr1_+_132298606 1.061 ENSMUST00000046071.4
Klhdc8a
kelch domain containing 8A
chr2_-_66634952 0.938 ENSMUST00000100064.2
ENSMUST00000100063.2
Scn9a

sodium channel, voltage-gated, type IX, alpha

chr2_+_104095796 0.908 ENSMUST00000040423.5
ENSMUST00000168176.1
Cd59a

CD59a antigen

chr11_-_75422524 0.870 ENSMUST00000125982.1
ENSMUST00000137103.1
Serpinf1

serine (or cysteine) peptidase inhibitor, clade F, member 1

chr4_+_156026304 0.868 ENSMUST00000040274.7
ENSMUST00000122001.1
Tnfrsf18

tumor necrosis factor receptor superfamily, member 18

chr8_-_70760889 0.758 ENSMUST00000038626.8
Mpv17l2
MPV17 mitochondrial membrane protein-like 2
chr5_+_24985840 0.756 ENSMUST00000075081.6
1500035N22Rik
RIKEN cDNA 1500035N22 gene
chr5_-_73338580 0.714 ENSMUST00000087195.5
Ociad2
OCIA domain containing 2
chr6_+_125552948 0.654 ENSMUST00000112254.1
ENSMUST00000112253.1
ENSMUST00000001995.7
Vwf


Von Willebrand factor homolog


chr1_-_40790642 0.653 ENSMUST00000039672.5
Mfsd9
major facilitator superfamily domain containing 9
chr13_+_42709482 0.632 ENSMUST00000066928.5
ENSMUST00000148891.1
Phactr1

phosphatase and actin regulator 1

chr13_+_104109737 0.567 ENSMUST00000044385.7
Sgtb
small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta
chr2_-_30194112 0.509 ENSMUST00000113659.1
ENSMUST00000113660.1
Ccbl1

cysteine conjugate-beta lyase 1

chr6_-_113719880 0.508 ENSMUST00000064993.5
Ghrl
ghrelin
chr13_-_19395728 0.475 ENSMUST00000039694.7
Stard3nl
STARD3 N-terminal like
chr5_-_88675190 0.472 ENSMUST00000133532.1
ENSMUST00000150438.1
Grsf1

G-rich RNA sequence binding factor 1

chr6_+_127453705 0.470 ENSMUST00000039680.5
Parp11
poly (ADP-ribose) polymerase family, member 11
chr12_+_76533540 0.467 ENSMUST00000075249.4
Plekhg3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr8_+_31091593 0.460 ENSMUST00000161713.1
Dusp26
dual specificity phosphatase 26 (putative)
chr2_+_156613664 0.444 ENSMUST00000169464.2
ENSMUST00000109567.3
Dlgap4

discs, large homolog-associated protein 4 (Drosophila)

chr11_+_116918844 0.412 ENSMUST00000103027.3
Mgat5b
mannoside acetylglucosaminyltransferase 5, isoenzyme B
chr6_-_43666158 0.407 ENSMUST00000114644.2
ENSMUST00000150599.1
ENSMUST00000067888.7
Tpk1


thiamine pyrophosphokinase


chr6_+_127453667 0.388 ENSMUST00000112193.1
Parp11
poly (ADP-ribose) polymerase family, member 11
chr14_+_51893610 0.385 ENSMUST00000047726.5
ENSMUST00000161888.1
Slc39a2

solute carrier family 39 (zinc transporter), member 2

chr11_-_102218923 0.371 ENSMUST00000131254.1
Hdac5
histone deacetylase 5
chr16_-_16359016 0.355 ENSMUST00000023477.7
ENSMUST00000096229.3
ENSMUST00000115749.1
Dnm1l


dynamin 1-like


chr2_+_155775333 0.348 ENSMUST00000029141.5
Mmp24
matrix metallopeptidase 24
chr13_+_44730726 0.331 ENSMUST00000173704.1
ENSMUST00000044608.7
ENSMUST00000173367.1
Jarid2


jumonji, AT rich interactive domain 2


chr13_-_38658991 0.327 ENSMUST00000001757.7
Eef1e1
eukaryotic translation elongation factor 1 epsilon 1
chr13_+_104109752 0.327 ENSMUST00000160322.1
ENSMUST00000159574.1
Sgtb

small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta

chr2_+_32646586 0.313 ENSMUST00000009705.7
ENSMUST00000167841.1
Eng

endoglin

chr9_+_114688782 0.306 ENSMUST00000047404.6
Dync1li1
dynein cytoplasmic 1 light intermediate chain 1
chr2_+_121171155 0.288 ENSMUST00000110658.1
Tubgcp4
tubulin, gamma complex associated protein 4
chr8_+_70616816 0.276 ENSMUST00000052437.3
Lrrc25
leucine rich repeat containing 25
chr19_+_6276725 0.269 ENSMUST00000025684.3
Ehd1
EH-domain containing 1
chr18_+_61105844 0.267 ENSMUST00000115268.3
Csf1r
colony stimulating factor 1 receptor
chr15_-_3979432 0.257 ENSMUST00000022791.8
Fbxo4
F-box protein 4
chr19_-_10869757 0.251 ENSMUST00000120524.1
ENSMUST00000025645.7
Tmem132a

transmembrane protein 132A

chr4_+_63544747 0.243 ENSMUST00000035301.6
Atp6v1g1
ATPase, H+ transporting, lysosomal V1 subunit G1
chr8_-_105758570 0.235 ENSMUST00000155038.2
ENSMUST00000013294.9
Gfod2

glucose-fructose oxidoreductase domain containing 2

chr14_+_57424054 0.230 ENSMUST00000122063.1
Ift88
intraflagellar transport 88
chr8_+_94810446 0.224 ENSMUST00000034232.1
Ccl17
chemokine (C-C motif) ligand 17
chr3_-_63929376 0.221 ENSMUST00000061706.6
E130311K13Rik
RIKEN cDNA E130311K13 gene
chr8_-_116978908 0.219 ENSMUST00000070577.5
1700030J22Rik
RIKEN cDNA 1700030J22 gene
chr5_+_117976761 0.217 ENSMUST00000035579.6
Fbxo21
F-box protein 21
chrX_-_17571563 0.216 ENSMUST00000177213.1
Fundc1
FUN14 domain containing 1
chr10_+_89744988 0.212 ENSMUST00000020112.5
Uhrf1bp1l
UHRF1 (ICBP90) binding protein 1-like
chr10_-_33951190 0.199 ENSMUST00000048222.4
Zufsp
zinc finger with UFM1-specific peptidase domain
chrX_-_17572241 0.190 ENSMUST00000176638.1
ENSMUST00000026016.6
Fundc1

FUN14 domain containing 1

chr17_-_24150910 0.176 ENSMUST00000052462.6
Pdpk1
3-phosphoinositide dependent protein kinase 1
chr6_-_122856151 0.160 ENSMUST00000042081.8
C3ar1
complement component 3a receptor 1
chr8_+_33732237 0.155 ENSMUST00000171010.1
Gtf2e2
general transcription factor II E, polypeptide 2 (beta subunit)
chr17_+_46110982 0.154 ENSMUST00000024763.3
ENSMUST00000123646.1
Mrps18a

mitochondrial ribosomal protein S18A

chr11_-_102365111 0.141 ENSMUST00000006749.9
Slc4a1
solute carrier family 4 (anion exchanger), member 1
chr12_+_69724939 0.135 ENSMUST00000021372.5
Atp5s
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit s
chr5_-_88675613 0.131 ENSMUST00000113234.1
ENSMUST00000153565.1
Grsf1

G-rich RNA sequence binding factor 1

chr4_-_155863362 0.108 ENSMUST00000030949.3
Tas1r3
taste receptor, type 1, member 3
chr13_-_32851176 0.106 ENSMUST00000091668.5
ENSMUST00000076352.6
Serpinb1a

serine (or cysteine) peptidase inhibitor, clade B, member 1a

chr11_-_100650693 0.103 ENSMUST00000103119.3
Zfp385c
zinc finger protein 385C
chr7_-_98178254 0.103 ENSMUST00000040971.7
Capn5
calpain 5
chr2_+_121171204 0.100 ENSMUST00000039541.5
ENSMUST00000110657.1
Tubgcp4

tubulin, gamma complex associated protein 4

chr8_-_124897685 0.097 ENSMUST00000098312.2
Exoc8
exocyst complex component 8
chr11_+_35769462 0.095 ENSMUST00000018990.7
Pank3
pantothenate kinase 3
chr7_-_27228605 0.094 ENSMUST00000003850.7
Itpkc
inositol 1,4,5-trisphosphate 3-kinase C
chr7_+_126759601 0.064 ENSMUST00000050201.4
ENSMUST00000057669.9
Mapk3

mitogen-activated protein kinase 3

chr5_+_24586721 0.046 ENSMUST00000121863.1
ENSMUST00000088295.4
Chpf2

chondroitin polymerizing factor 2

chr11_-_88851462 0.044 ENSMUST00000107903.1
Akap1
A kinase (PRKA) anchor protein 1
chr1_+_37997975 0.010 ENSMUST00000027252.7
Eif5b
eukaryotic translation initiation factor 5B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.3 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.2 0.5 GO:0035482 intestine smooth muscle contraction(GO:0014827) gastric motility(GO:0035482) gastric emptying(GO:0035483) regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) negative regulation of tumor necrosis factor biosynthetic process(GO:0042536) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938) positive regulation of cortisol secretion(GO:0051464) regulation of gastro-intestinal system smooth muscle contraction(GO:1904304) regulation of small intestine smooth muscle contraction(GO:1904347) small intestine smooth muscle contraction(GO:1990770)
0.2 0.5 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.2 0.9 GO:0090272 negative regulation of fibroblast growth factor production(GO:0090272)
0.1 0.8 GO:0061668 mitochondrial ribosome assembly(GO:0061668)
0.1 0.4 GO:1904578 response to thapsigargin(GO:1904578) cellular response to thapsigargin(GO:1904579)
0.1 0.3 GO:1905072 detection of oxygen(GO:0003032) positive regulation of vascular smooth muscle cell differentiation(GO:1905065) cardiac jelly development(GO:1905072)
0.1 0.2 GO:0007290 spermatid nucleus elongation(GO:0007290)
0.1 0.3 GO:2001137 positive regulation of endocytic recycling(GO:2001137)
0.1 0.3 GO:0038145 macrophage colony-stimulating factor signaling pathway(GO:0038145)
0.1 0.3 GO:2000774 positive regulation of cellular senescence(GO:2000774)
0.1 2.2 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
0.1 0.4 GO:0051418 interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)
0.1 0.2 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.0 1.3 GO:0090140 regulation of mitochondrial fission(GO:0090140)
0.0 0.9 GO:0048266 behavioral response to pain(GO:0048266)
0.0 0.4 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.0 0.3 GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
0.0 0.3 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.0 1.2 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.3 GO:0044331 cell-cell adhesion mediated by cadherin(GO:0044331)
0.0 0.3 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.0 0.1 GO:0050912 detection of chemical stimulus involved in sensory perception(GO:0050907) detection of chemical stimulus involved in sensory perception of taste(GO:0050912)
0.0 0.4 GO:0006767 water-soluble vitamin metabolic process(GO:0006767)
0.0 0.2 GO:0006968 cellular defense response(GO:0006968)
0.0 0.1 GO:0001927 exocyst assembly(GO:0001927)
0.0 0.1 GO:0000189 MAPK import into nucleus(GO:0000189)
0.0 0.9 GO:0006998 nuclear envelope organization(GO:0006998)
0.0 0.2 GO:0036296 cellular response to increased oxygen levels(GO:0036295) response to increased oxygen levels(GO:0036296)
0.0 0.4 GO:0006829 zinc II ion transport(GO:0006829)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.3 GO:0043203 axon hillock(GO:0043203)
0.1 0.7 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 0.3 GO:0020018 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
0.1 0.3 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.1 0.9 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 0.4 GO:0000923 equatorial microtubule organizing center(GO:0000923)
0.1 0.2 GO:0005673 transcription factor TFIIE complex(GO:0005673)
0.0 0.4 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.5 GO:0044232 organelle membrane contact site(GO:0044232)
0.0 0.2 GO:0060091 kinocilium(GO:0060091)
0.0 0.3 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 1.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.3 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.4 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.2 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0 0.8 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.6 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.3 GO:0032588 trans-Golgi network membrane(GO:0032588)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.1 2.2 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.1 0.4 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.1 0.4 GO:0016778 diphosphotransferase activity(GO:0016778)
0.1 0.7 GO:0019865 immunoglobulin binding(GO:0019865)
0.1 0.3 GO:0005534 galactose binding(GO:0005534)
0.1 0.2 GO:0004875 complement receptor activity(GO:0004875)
0.1 2.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 0.4 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.0 0.9 GO:0031402 sodium ion binding(GO:0031402)
0.0 0.9 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.5 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.0 0.4 GO:0051011 microtubule minus-end binding(GO:0051011)
0.0 0.1 GO:0008527 taste receptor activity(GO:0008527)
0.0 0.4 GO:0051400 BH domain binding(GO:0051400)
0.0 0.6 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.1 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.3 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.2 GO:0016004 phospholipase activator activity(GO:0016004) lipase activator activity(GO:0060229)
0.0 0.4 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.1 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.2 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 2.2 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.1 0.5 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.5 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.3 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.4 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 1.4 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.3 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.2 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling