Motif ID: Tbx2
Z-value: 0.461

Transcription factors associated with Tbx2:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Tbx2 | ENSMUSG00000000093.6 | Tbx2 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Tbx2 | mm10_v2_chr11_+_85832551_85832551 | -0.24 | 1.3e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.7 | 3.5 | GO:0035262 | gonad morphogenesis(GO:0035262) |
0.4 | 1.3 | GO:0045110 | intermediate filament bundle assembly(GO:0045110) |
0.3 | 1.2 | GO:0044330 | canonical Wnt signaling pathway involved in positive regulation of wound healing(GO:0044330) lactic acid secretion(GO:0046722) regulation of metanephric cap mesenchymal cell proliferation(GO:0090095) positive regulation of metanephric cap mesenchymal cell proliferation(GO:0090096) |
0.3 | 1.4 | GO:0061086 | negative regulation of histone H3-K27 methylation(GO:0061086) |
0.2 | 0.6 | GO:1902277 | negative regulation of pancreatic amylase secretion(GO:1902277) |
0.2 | 0.7 | GO:0014005 | microglia differentiation(GO:0014004) microglia development(GO:0014005) |
0.2 | 0.9 | GO:0060467 | negative regulation of fertilization(GO:0060467) |
0.1 | 0.4 | GO:0044028 | DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029) |
0.1 | 0.5 | GO:0030240 | skeletal muscle thin filament assembly(GO:0030240) |
0.1 | 0.2 | GO:0090526 | regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526) |
0.1 | 0.2 | GO:0015772 | disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772) |
0.1 | 0.6 | GO:0035735 | intraciliary transport involved in cilium morphogenesis(GO:0035735) |
0.1 | 0.4 | GO:0007386 | compartment pattern specification(GO:0007386) |
0.1 | 0.4 | GO:2001012 | mesenchymal cell differentiation involved in kidney development(GO:0072161) mesenchymal cell differentiation involved in renal system development(GO:2001012) |
0.1 | 1.1 | GO:1904262 | negative regulation of TORC1 signaling(GO:1904262) |
0.1 | 0.2 | GO:0033364 | mast cell secretory granule organization(GO:0033364) |
0.1 | 0.2 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
0.1 | 0.6 | GO:0036371 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
0.1 | 0.3 | GO:1903764 | regulation of potassium ion export across plasma membrane(GO:1903764) |
0.1 | 0.3 | GO:0019355 | nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process(GO:0034627) 'de novo' NAD biosynthetic process from aspartate(GO:0034628) |
0.1 | 0.2 | GO:0002182 | cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248) |
0.1 | 0.2 | GO:0036118 | hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106) |
0.0 | 0.1 | GO:0090327 | negative regulation of locomotion involved in locomotory behavior(GO:0090327) |
0.0 | 0.6 | GO:0060501 | positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) |
0.0 | 0.2 | GO:0015867 | ATP transport(GO:0015867) |
0.0 | 0.5 | GO:0097067 | cellular response to thyroid hormone stimulus(GO:0097067) |
0.0 | 0.1 | GO:0001928 | regulation of exocyst assembly(GO:0001928) |
0.0 | 0.5 | GO:0046543 | development of secondary female sexual characteristics(GO:0046543) |
0.0 | 0.1 | GO:0070973 | protein localization to endoplasmic reticulum exit site(GO:0070973) |
0.0 | 1.4 | GO:0043551 | regulation of phosphatidylinositol 3-kinase activity(GO:0043551) |
0.0 | 1.2 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
0.0 | 0.9 | GO:0010107 | potassium ion import(GO:0010107) |
0.0 | 1.0 | GO:0014912 | negative regulation of smooth muscle cell migration(GO:0014912) |
0.0 | 0.9 | GO:0042149 | cellular response to glucose starvation(GO:0042149) |
0.0 | 0.4 | GO:0048875 | chemical homeostasis within a tissue(GO:0048875) |
0.0 | 0.2 | GO:0050910 | detection of mechanical stimulus involved in sensory perception of sound(GO:0050910) |
0.0 | 0.1 | GO:0046645 | positive regulation of gamma-delta T cell differentiation(GO:0045588) positive regulation of gamma-delta T cell activation(GO:0046645) |
0.0 | 0.1 | GO:1902219 | negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219) |
0.0 | 0.8 | GO:0036075 | endochondral ossification(GO:0001958) replacement ossification(GO:0036075) |
0.0 | 0.2 | GO:0035095 | behavioral response to nicotine(GO:0035095) |
0.0 | 0.2 | GO:0090161 | Golgi ribbon formation(GO:0090161) |
0.0 | 0.2 | GO:0010457 | centriole-centriole cohesion(GO:0010457) |
0.0 | 0.1 | GO:0032929 | negative regulation of superoxide anion generation(GO:0032929) |
0.0 | 0.0 | GO:2001160 | regulation of histone H3-K79 methylation(GO:2001160) |
0.0 | 0.2 | GO:0007220 | Notch receptor processing(GO:0007220) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 1.3 | GO:0033596 | TSC1-TSC2 complex(GO:0033596) |
0.1 | 0.4 | GO:0005943 | phosphatidylinositol 3-kinase complex, class IA(GO:0005943) |
0.1 | 1.8 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
0.1 | 0.2 | GO:0002141 | stereocilia ankle link(GO:0002141) |
0.1 | 1.4 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
0.0 | 0.3 | GO:0042629 | mast cell granule(GO:0042629) |
0.0 | 1.0 | GO:0043034 | costamere(GO:0043034) |
0.0 | 0.2 | GO:1990316 | ATG1/ULK1 kinase complex(GO:1990316) |
0.0 | 1.2 | GO:0005719 | nuclear euchromatin(GO:0005719) |
0.0 | 0.8 | GO:0043194 | axon initial segment(GO:0043194) |
0.0 | 0.5 | GO:0071565 | nBAF complex(GO:0071565) |
0.0 | 0.2 | GO:0070765 | gamma-secretase complex(GO:0070765) |
0.0 | 0.6 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
0.0 | 0.1 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
0.0 | 0.2 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
0.0 | 0.1 | GO:0030015 | CCR4-NOT core complex(GO:0030015) |
0.0 | 0.2 | GO:0070382 | exocytic vesicle(GO:0070382) |
0.0 | 0.2 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
0.0 | 0.4 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 1.8 | GO:0046935 | 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935) |
0.2 | 0.9 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
0.1 | 1.0 | GO:0050291 | sphingosine N-acyltransferase activity(GO:0050291) |
0.1 | 0.2 | GO:0008515 | sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157) |
0.1 | 1.2 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
0.1 | 0.2 | GO:0015228 | coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122) |
0.1 | 0.3 | GO:0030292 | protein tyrosine kinase inhibitor activity(GO:0030292) |
0.1 | 0.3 | GO:0004515 | nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515) |
0.1 | 0.4 | GO:0004652 | polynucleotide adenylyltransferase activity(GO:0004652) |
0.1 | 0.2 | GO:0050501 | hyaluronan synthase activity(GO:0050501) |
0.1 | 0.4 | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813) |
0.1 | 1.3 | GO:0043274 | phospholipase binding(GO:0043274) |
0.0 | 1.0 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
0.0 | 0.1 | GO:0042610 | CD8 receptor binding(GO:0042610) |
0.0 | 0.2 | GO:0070728 | leucine binding(GO:0070728) |
0.0 | 0.4 | GO:0031802 | type 5 metabotropic glutamate receptor binding(GO:0031802) |
0.0 | 1.7 | GO:0070888 | E-box binding(GO:0070888) |
0.0 | 0.1 | GO:0032184 | SUMO polymer binding(GO:0032184) |
0.0 | 0.1 | GO:0005128 | erythropoietin receptor binding(GO:0005128) |
0.0 | 0.3 | GO:0051428 | peptide hormone receptor binding(GO:0051428) |
0.0 | 0.3 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
0.0 | 0.9 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
0.0 | 0.1 | GO:0042806 | fucose binding(GO:0042806) |
0.0 | 1.4 | GO:0035064 | methylated histone binding(GO:0035064) |
0.0 | 0.4 | GO:0004385 | guanylate kinase activity(GO:0004385) |
0.0 | 0.2 | GO:0022848 | acetylcholine-gated cation channel activity(GO:0022848) |
0.0 | 0.6 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
0.0 | 0.2 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
0.0 | 0.2 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
0.0 | 0.6 | GO:0030507 | spectrin binding(GO:0030507) |
0.0 | 0.6 | GO:0048487 | beta-tubulin binding(GO:0048487) |
0.0 | 0.4 | GO:0005112 | Notch binding(GO:0005112) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 2.2 | PID_TRAIL_PATHWAY | TRAIL signaling pathway |
0.0 | 1.2 | PID_MYC_PATHWAY | C-MYC pathway |
0.0 | 0.9 | ST_MYOCYTE_AD_PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
0.0 | 0.3 | PID_BCR_5PATHWAY | BCR signaling pathway |
0.0 | 0.6 | PID_CERAMIDE_PATHWAY | Ceramide signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 1.8 | REACTOME_IL_7_SIGNALING | Genes involved in Interleukin-7 signaling |
0.1 | 1.3 | REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
0.0 | 1.0 | REACTOME_OTHER_SEMAPHORIN_INTERACTIONS | Genes involved in Other semaphorin interactions |
0.0 | 1.2 | REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
0.0 | 1.0 | REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
0.0 | 1.0 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
0.0 | 0.1 | REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
0.0 | 0.4 | REACTOME_TIE2_SIGNALING | Genes involved in Tie2 Signaling |
0.0 | 0.2 | REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
0.0 | 0.1 | REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR | Genes involved in Trafficking and processing of endosomal TLR |
0.0 | 0.3 | REACTOME_DEADENYLATION_OF_MRNA | Genes involved in Deadenylation of mRNA |
0.0 | 0.2 | REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR | Genes involved in Regulated proteolysis of p75NTR |
0.0 | 0.2 | REACTOME_HYALURONAN_METABOLISM | Genes involved in Hyaluronan metabolism |
0.0 | 0.2 | REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |