Motif ID: Nkx3-1

Z-value: 0.709


Transcription factors associated with Nkx3-1:

Gene SymbolEntrez IDGene Name
Nkx3-1 ENSMUSG00000022061.8 Nkx3-1



Activity profile for motif Nkx3-1.

activity profile for motif Nkx3-1


Sorted Z-values histogram for motif Nkx3-1

Sorted Z-values for motif Nkx3-1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx3-1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_132757162 5.263 ENSMUST00000030709.8
Smpdl3b
sphingomyelin phosphodiesterase, acid-like 3B
chr10_-_13324160 4.802 ENSMUST00000105545.4
Phactr2
phosphatase and actin regulator 2
chr3_-_57575760 4.684 ENSMUST00000029380.7
Wwtr1
WW domain containing transcription regulator 1
chr3_-_57575907 4.637 ENSMUST00000120977.1
Wwtr1
WW domain containing transcription regulator 1
chrX_+_100625737 3.918 ENSMUST00000048962.3
Kif4
kinesin family member 4
chr9_+_78191966 3.871 ENSMUST00000034903.5
Gsta4
glutathione S-transferase, alpha 4
chr18_+_60963517 2.893 ENSMUST00000115295.2
ENSMUST00000039904.6
Camk2a

calcium/calmodulin-dependent protein kinase II alpha

chr9_+_72438534 2.521 ENSMUST00000034746.8
Mns1
meiosis-specific nuclear structural protein 1
chr6_+_128362919 2.418 ENSMUST00000073316.6
Foxm1
forkhead box M1
chr10_-_13324250 2.274 ENSMUST00000105543.1
Phactr2
phosphatase and actin regulator 2
chr5_+_136919137 2.265 ENSMUST00000181045.1
4933404O12Rik
RIKEN cDNA 4933404O12 gene
chr1_-_163289214 2.264 ENSMUST00000183691.1
Prrx1
paired related homeobox 1
chr9_+_72438519 2.228 ENSMUST00000184604.1
Mns1
meiosis-specific nuclear structural protein 1
chr3_-_104818539 2.227 ENSMUST00000106774.1
ENSMUST00000106775.1
ENSMUST00000166979.1
ENSMUST00000136148.1
Mov10



Moloney leukemia virus 10



chr8_+_114133557 2.167 ENSMUST00000073521.5
ENSMUST00000066514.6
Nudt7

nudix (nucleoside diphosphate linked moiety X)-type motif 7

chr8_+_114133635 2.127 ENSMUST00000147605.1
ENSMUST00000134593.1
Nudt7

nudix (nucleoside diphosphate linked moiety X)-type motif 7

chr17_+_56304313 2.101 ENSMUST00000113035.1
ENSMUST00000113039.2
ENSMUST00000142387.1
Uhrf1


ubiquitin-like, containing PHD and RING finger domains, 1


chr9_-_124493793 1.860 ENSMUST00000178787.1
Gm21836
predicted gene, 21836
chr5_-_8422582 1.782 ENSMUST00000168500.1
ENSMUST00000002368.9
Dbf4

DBF4 homolog (S. cerevisiae)

chr17_-_25727364 1.733 ENSMUST00000170070.1
ENSMUST00000048054.7
Chtf18

CTF18, chromosome transmission fidelity factor 18

chrX_-_75874536 1.729 ENSMUST00000033547.7
Pls3
plastin 3 (T-isoform)
chrX_-_75875101 1.719 ENSMUST00000114059.3
Pls3
plastin 3 (T-isoform)
chr1_-_133907053 1.678 ENSMUST00000149380.1
ENSMUST00000124051.2
Optc

opticin

chr9_-_20976762 1.585 ENSMUST00000054197.5
S1pr2
sphingosine-1-phosphate receptor 2
chr5_-_149051300 1.535 ENSMUST00000110505.1
Hmgb1
high mobility group box 1
chr8_-_123318553 1.520 ENSMUST00000118395.1
ENSMUST00000035495.8
Fanca

Fanconi anemia, complementation group A

chr7_+_58658181 1.448 ENSMUST00000168747.1
Atp10a
ATPase, class V, type 10A
chr4_-_140774196 1.348 ENSMUST00000026381.6
Padi4
peptidyl arginine deiminase, type IV
chr10_+_94514825 1.338 ENSMUST00000065060.5
Tmcc3
transmembrane and coiled coil domains 3
chr1_-_133906973 1.195 ENSMUST00000126123.1
Optc
opticin
chr11_+_97685903 1.136 ENSMUST00000107583.2
Cisd3
CDGSH iron sulfur domain 3
chr12_+_52516077 1.135 ENSMUST00000110725.1
Arhgap5
Rho GTPase activating protein 5
chrX_+_164269371 1.128 ENSMUST00000145412.1
ENSMUST00000033749.7
Pir

pirin

chr13_+_51408618 1.102 ENSMUST00000087978.3
S1pr3
sphingosine-1-phosphate receptor 3
chr4_+_62619515 1.093 ENSMUST00000084521.4
ENSMUST00000107424.1
Rgs3

regulator of G-protein signaling 3

chr10_-_12861735 1.007 ENSMUST00000076817.4
Utrn
utrophin
chr18_+_82910863 1.004 ENSMUST00000171238.1
Zfp516
zinc finger protein 516
chr11_+_97685794 0.993 ENSMUST00000107584.1
ENSMUST00000107585.2
Cisd3

CDGSH iron sulfur domain 3

chr4_-_156255327 0.988 ENSMUST00000179919.1
Samd11
sterile alpha motif domain containing 11
chr4_+_3940747 0.980 ENSMUST00000119403.1
Chchd7
coiled-coil-helix-coiled-coil-helix domain containing 7
chr4_+_32623985 0.896 ENSMUST00000108178.1
Casp8ap2
caspase 8 associated protein 2
chr2_+_110597298 0.853 ENSMUST00000045972.6
ENSMUST00000111026.2
Slc5a12

solute carrier family 5 (sodium/glucose cotransporter), member 12

chr2_+_62664279 0.853 ENSMUST00000028257.2
Gca
grancalcin
chrX_-_100625901 0.796 ENSMUST00000059099.6
Pdzd11
PDZ domain containing 11
chr1_-_75046639 0.791 ENSMUST00000152855.1
Nhej1
nonhomologous end-joining factor 1
chr11_-_21370452 0.790 ENSMUST00000102875.4
Ugp2
UDP-glucose pyrophosphorylase 2
chr8_+_36457548 0.787 ENSMUST00000135373.1
ENSMUST00000147525.1
6430573F11Rik

RIKEN cDNA 6430573F11 gene

chr6_-_108185552 0.763 ENSMUST00000167338.1
ENSMUST00000172188.1
ENSMUST00000032191.9
Sumf1


sulfatase modifying factor 1


chr5_-_86676346 0.754 ENSMUST00000038448.6
Tmprss11bnl
transmembrane protease, serine 11b N terminal like
chr4_+_116708571 0.746 ENSMUST00000106462.2
ENSMUST00000138305.1
ENSMUST00000125671.1
ENSMUST00000130828.1
Ccdc163



coiled-coil domain containing 163



chr17_+_37270214 0.731 ENSMUST00000038580.6
H2-M3
histocompatibility 2, M region locus 3
chr10_+_100488289 0.731 ENSMUST00000164751.1
Cep290
centrosomal protein 290
chr11_-_83645621 0.730 ENSMUST00000182502.1
Rpl9-ps1
ribosomal protein L9, pseudogene 1
chr1_-_53297001 0.722 ENSMUST00000126590.1
ENSMUST00000126412.1
ENSMUST00000135246.1
ENSMUST00000027267.7
Pms1



postmeiotic segregation increased 1 (S. cerevisiae)



chr13_-_99900645 0.679 ENSMUST00000022150.6
Cartpt
CART prepropeptide
chr1_-_162866502 0.668 ENSMUST00000046049.7
Fmo1
flavin containing monooxygenase 1
chr5_+_90367204 0.659 ENSMUST00000068250.3
Gm9958
predicted gene 9958
chr15_-_50882806 0.623 ENSMUST00000184885.1
Trps1
trichorhinophalangeal syndrome I (human)
chr13_+_23571382 0.608 ENSMUST00000079251.5
Hist1h2bg
histone cluster 1, H2bg
chr10_+_4432467 0.606 ENSMUST00000095893.4
ENSMUST00000118544.1
ENSMUST00000117489.1
1700052N19Rik


RIKEN cDNA 1700052N19 gene


chr14_-_55788810 0.599 ENSMUST00000022830.6
ENSMUST00000168716.1
ENSMUST00000178399.1
Ripk3


receptor-interacting serine-threonine kinase 3


chr6_+_88465409 0.545 ENSMUST00000032165.9
Ruvbl1
RuvB-like protein 1
chr5_-_21785115 0.540 ENSMUST00000115193.1
ENSMUST00000115192.1
ENSMUST00000115195.1
ENSMUST00000030771.5
Dnajc2



DnaJ (Hsp40) homolog, subfamily C, member 2



chrX_+_7579666 0.536 ENSMUST00000115740.1
ENSMUST00000115739.1
Foxp3

forkhead box P3

chrX_+_56317608 0.535 ENSMUST00000151426.1
ENSMUST00000138262.1
1600025M17Rik

RIKEN cDNA 1600025M17 gene

chr10_-_128211788 0.532 ENSMUST00000061995.8
Spryd4
SPRY domain containing 4
chr11_-_3976778 0.526 ENSMUST00000042344.1
4930556J24Rik
RIKEN cDNA 4930556J24 gene
chr10_-_62486575 0.523 ENSMUST00000092473.3
Vps26a
vacuolar protein sorting 26 homolog A (yeast)
chr17_-_65772686 0.494 ENSMUST00000070673.7
Rab31
RAB31, member RAS oncogene family
chr1_+_167598450 0.488 ENSMUST00000111386.1
ENSMUST00000111384.1
Rxrg

retinoid X receptor gamma

chr5_+_138161071 0.469 ENSMUST00000019638.8
ENSMUST00000110951.1
Cops6

COP9 (constitutive photomorphogenic) homolog, subunit 6 (Arabidopsis thaliana)

chr1_+_167598384 0.468 ENSMUST00000015987.3
Rxrg
retinoid X receptor gamma
chr14_+_79515618 0.455 ENSMUST00000110835.1
Elf1
E74-like factor 1
chr7_+_100537192 0.454 ENSMUST00000120454.1
Coa4
cytochrome c oxidase assembly factor 4
chr9_-_35570393 0.445 ENSMUST00000115110.4
Hyls1
hydrolethalus syndrome 1
chr7_+_100537052 0.443 ENSMUST00000054310.3
Coa4
cytochrome c oxidase assembly factor 4
chr1_-_175688353 0.431 ENSMUST00000104984.1
Chml
choroideremia-like
chr2_+_79707780 0.422 ENSMUST00000090760.2
ENSMUST00000040863.4
ENSMUST00000111780.2
Ppp1r1c


protein phosphatase 1, regulatory (inhibitor) subunit 1C


chr10_-_14718191 0.412 ENSMUST00000020016.4
Gje1
gap junction protein, epsilon 1
chr9_+_105053239 0.393 ENSMUST00000035177.8
ENSMUST00000149243.1
Mrpl3

mitochondrial ribosomal protein L3

chr14_+_47663756 0.380 ENSMUST00000022391.7
Ktn1
kinectin 1
chr10_+_90576708 0.371 ENSMUST00000182430.1
ENSMUST00000182960.1
ENSMUST00000182045.1
ENSMUST00000182083.1
Anks1b



ankyrin repeat and sterile alpha motif domain containing 1B



chr11_-_80080928 0.364 ENSMUST00000103233.3
ENSMUST00000061283.8
Crlf3

cytokine receptor-like factor 3

chr10_+_90576252 0.361 ENSMUST00000182427.1
ENSMUST00000182053.1
ENSMUST00000182113.1
Anks1b


ankyrin repeat and sterile alpha motif domain containing 1B


chr7_+_43607169 0.358 ENSMUST00000120935.1
ENSMUST00000127765.1
ENSMUST00000032661.7
Zfp819


zinc finger protein 819


chr8_-_23237623 0.342 ENSMUST00000033950.5
Gins4
GINS complex subunit 4 (Sld5 homolog)
chr2_+_71873224 0.341 ENSMUST00000006669.5
Pdk1
pyruvate dehydrogenase kinase, isoenzyme 1
chr7_+_75455534 0.333 ENSMUST00000147005.1
ENSMUST00000166315.1
Akap13

A kinase (PRKA) anchor protein 13

chrX_+_140456613 0.322 ENSMUST00000033809.3
Prps1
phosphoribosyl pyrophosphate synthetase 1
chrY_+_17874741 0.316 ENSMUST00000177639.1
Gm20831
predicted gene, 20831
chr9_+_89199319 0.291 ENSMUST00000138109.1
Mthfs
5, 10-methenyltetrahydrofolate synthetase
chr14_-_54864055 0.283 ENSMUST00000142283.2
Homez
homeodomain leucine zipper-encoding gene
chr16_+_36934976 0.271 ENSMUST00000023531.8
Hcls1
hematopoietic cell specific Lyn substrate 1
chr10_+_90576678 0.271 ENSMUST00000182284.1
Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr7_-_127930066 0.252 ENSMUST00000032988.8
Prss8
protease, serine, 8 (prostasin)
chr16_+_20535475 0.248 ENSMUST00000090023.6
ENSMUST00000007216.8
Ap2m1

adaptor-related protein complex 2, mu 1 subunit

chr9_+_40873981 0.242 ENSMUST00000067375.3
Bsx
brain specific homeobox
chr1_-_156034800 0.237 ENSMUST00000169241.1
Tor1aip1
torsin A interacting protein 1
chr3_+_14863495 0.231 ENSMUST00000029076.4
Car3
carbonic anhydrase 3
chr12_-_54695829 0.231 ENSMUST00000162106.1
ENSMUST00000160085.1
ENSMUST00000161592.1
ENSMUST00000163433.1
Eapp



E2F-associated phosphoprotein



chr2_+_132846638 0.228 ENSMUST00000028835.6
ENSMUST00000110122.3
Crls1

cardiolipin synthase 1

chr10_+_90576570 0.227 ENSMUST00000182786.1
ENSMUST00000182600.1
Anks1b

ankyrin repeat and sterile alpha motif domain containing 1B

chr18_-_6241486 0.226 ENSMUST00000025083.7
Kif5b
kinesin family member 5B
chr9_+_78051938 0.217 ENSMUST00000024104.7
Gcm1
glial cells missing homolog 1 (Drosophila)
chr12_-_54695813 0.216 ENSMUST00000110713.3
Eapp
E2F-associated phosphoprotein
chr5_-_110046486 0.216 ENSMUST00000167969.1
Gm17655
predicted gene, 17655
chr14_-_46831984 0.208 ENSMUST00000181311.1
ENSMUST00000074862.2
Gm10101

predicted gene 10101

chr18_-_42262053 0.207 ENSMUST00000097590.3
Lars
leucyl-tRNA synthetase
chr7_-_121035096 0.196 ENSMUST00000065740.2
Gm9905
predicted gene 9905
chrX_+_56454871 0.182 ENSMUST00000039374.2
ENSMUST00000101553.2
Ddx26b

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B

chr2_-_153015331 0.176 ENSMUST00000028972.8
Pdrg1
p53 and DNA damage regulated 1
chr7_-_63938862 0.166 ENSMUST00000063694.8
Klf13
Kruppel-like factor 13
chr5_+_72914264 0.160 ENSMUST00000144843.1
Slain2
SLAIN motif family, member 2
chr15_-_52478228 0.159 ENSMUST00000081993.1
Gm10020
predicted pseudogene 10020
chr19_-_61297069 0.158 ENSMUST00000179346.1
Gm21060
predicted gene, 21060
chr19_+_8735808 0.151 ENSMUST00000049424.9
Wdr74
WD repeat domain 74
chr12_+_17266545 0.148 ENSMUST00000057288.5
Pdia6
protein disulfide isomerase associated 6
chr16_+_20611585 0.129 ENSMUST00000115522.2
ENSMUST00000119224.1
ENSMUST00000079600.4
ENSMUST00000120394.1
Ece2



endothelin converting enzyme 2



chr1_+_135133272 0.125 ENSMUST00000167080.1
Ptpn7
protein tyrosine phosphatase, non-receptor type 7
chr15_+_78597047 0.120 ENSMUST00000043069.5
Cyth4
cytohesin 4
chr7_+_110627650 0.092 ENSMUST00000033054.8
Adm
adrenomedullin
chr1_-_174921813 0.090 ENSMUST00000055294.3
Grem2
gremlin 2 homolog, cysteine knot superfamily (Xenopus laevis)
chr5_+_8422831 0.088 ENSMUST00000066921.3
Slc25a40
solute carrier family 25, member 40
chr10_+_90576777 0.084 ENSMUST00000183136.1
ENSMUST00000182595.1
Anks1b

ankyrin repeat and sterile alpha motif domain containing 1B

chr2_+_163994960 0.080 ENSMUST00000018470.3
Ywhab
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
chr13_-_41847482 0.080 ENSMUST00000072012.3
Adtrp
androgen dependent TFPI regulating protein
chr17_-_47692466 0.068 ENSMUST00000113300.1
Prickle4
prickle homolog 4 (Drosophila)
chr7_-_28598140 0.055 ENSMUST00000108283.1
ENSMUST00000040531.8
Pak4
Samd4b
p21 protein (Cdc42/Rac)-activated kinase 4
sterile alpha motif domain containing 4B
chr6_-_69284319 0.049 ENSMUST00000103349.1
Igkv4-69
immunoglobulin kappa variable 4-69
chr11_-_17008647 0.046 ENSMUST00000102881.3
Plek
pleckstrin
chr6_-_124857707 0.043 ENSMUST00000023958.3
Leprel2
leprecan-like 2
chr5_+_28071356 0.036 ENSMUST00000059155.10
Insig1
insulin induced gene 1
chr18_-_12862624 0.034 ENSMUST00000121808.1
ENSMUST00000118313.1
Osbpl1a

oxysterol binding protein-like 1A

chrX_-_111537947 0.028 ENSMUST00000132319.1
ENSMUST00000123951.1
Rps6ka6

ribosomal protein S6 kinase polypeptide 6

chr19_+_20601958 0.024 ENSMUST00000087638.3
Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
chr5_-_72559599 0.013 ENSMUST00000074948.4
ENSMUST00000087216.5
Nfxl1

nuclear transcription factor, X-box binding-like 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.3 GO:0015938 coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034) acetyl-CoA catabolic process(GO:0046356)
1.3 9.3 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.8 5.3 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.5 1.5 GO:0045819 plasmacytoid dendritic cell activation(GO:0002270) positive regulation of glycogen catabolic process(GO:0045819)
0.4 3.9 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.4 1.8 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.3 1.0 GO:0007525 somatic muscle development(GO:0007525)
0.3 1.6 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520)
0.3 4.7 GO:0070986 left/right axis specification(GO:0070986)
0.3 0.8 GO:0006011 UDP-glucose metabolic process(GO:0006011) glucose 1-phosphate metabolic process(GO:0019255)
0.3 1.3 GO:0002666 positive regulation of T cell tolerance induction(GO:0002666)
0.2 2.4 GO:2000781 positive regulation of double-strand break repair(GO:2000781)
0.2 3.4 GO:0051639 actin filament network formation(GO:0051639)
0.2 0.7 GO:0070093 negative regulation of glucagon secretion(GO:0070093)
0.2 2.9 GO:0099628 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
0.2 1.5 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.2 1.7 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.2 2.3 GO:0048664 neuron fate determination(GO:0048664)
0.2 0.8 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.1 0.6 GO:2000407 regulation of T cell extravasation(GO:2000407)
0.1 1.3 GO:0019240 citrulline biosynthetic process(GO:0019240)
0.1 0.9 GO:0036337 Fas signaling pathway(GO:0036337)
0.1 2.1 GO:0010216 maintenance of DNA methylation(GO:0010216)
0.1 0.5 GO:0010756 positive regulation of plasminogen activation(GO:0010756)
0.1 0.3 GO:0046101 hypoxanthine metabolic process(GO:0046100) hypoxanthine biosynthetic process(GO:0046101)
0.1 1.1 GO:0045602 negative regulation of endothelial cell differentiation(GO:0045602)
0.1 0.3 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.1 0.9 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.1 0.8 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.1 2.2 GO:0006379 mRNA cleavage(GO:0006379)
0.1 0.3 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.1 0.7 GO:0070995 NADPH oxidation(GO:0070995)
0.1 0.3 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.1 0.2 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.1 0.4 GO:0018344 protein geranylgeranylation(GO:0018344)
0.1 0.2 GO:0006438 valyl-tRNA aminoacylation(GO:0006438)
0.1 0.6 GO:0002227 innate immune response in mucosa(GO:0002227)
0.0 0.7 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 0.3 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.3 GO:0009396 folic acid-containing compound biosynthetic process(GO:0009396)
0.0 0.5 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.4 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.0 2.9 GO:0016525 negative regulation of angiogenesis(GO:0016525)
0.0 0.6 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.0 0.2 GO:0032049 cardiolipin biosynthetic process(GO:0032049)
0.0 1.0 GO:0050873 brown fat cell differentiation(GO:0050873)
0.0 1.4 GO:0015914 phospholipid transport(GO:0015914)
0.0 0.7 GO:0006298 mismatch repair(GO:0006298)
0.0 0.5 GO:0000338 protein deneddylation(GO:0000338)
0.0 1.0 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 0.2 GO:0071763 nuclear membrane organization(GO:0071763)
0.0 0.2 GO:0060056 mammary gland involution(GO:0060056)
0.0 1.1 GO:0002053 positive regulation of mesenchymal cell proliferation(GO:0002053)
0.0 0.5 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
0.0 0.8 GO:0006303 double-strand break repair via nonhomologous end joining(GO:0006303)
0.0 0.3 GO:0070633 transepithelial transport(GO:0070633)
0.0 0.7 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.0 0.5 GO:0090382 phagosome maturation(GO:0090382)
0.0 0.5 GO:2000279 negative regulation of DNA biosynthetic process(GO:2000279)
0.0 0.1 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.0 0.4 GO:0071158 positive regulation of cell cycle arrest(GO:0071158)
0.0 0.1 GO:1900116 sequestering of extracellular ligand from receptor(GO:0035581) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0 0.0 GO:0010920 negative regulation of inositol phosphate biosynthetic process(GO:0010920)
0.0 0.4 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.0 0.2 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 2.9 GO:0099573 glutamatergic postsynaptic density(GO:0099573)
0.2 1.7 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.1 0.7 GO:0032389 MutLalpha complex(GO:0032389)
0.1 1.5 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.1 0.8 GO:0032807 DNA ligase IV complex(GO:0032807)
0.1 0.5 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.1 0.3 GO:0000811 GINS complex(GO:0000811)
0.1 0.3 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.1 0.4 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.1 0.3 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.1 0.5 GO:0097255 R2TP complex(GO:0097255)
0.1 0.6 GO:0097342 ripoptosome(GO:0097342)
0.1 3.4 GO:0032420 stereocilium(GO:0032420)
0.1 4.7 GO:0005882 intermediate filament(GO:0005882)
0.1 1.0 GO:0070938 contractile ring(GO:0070938)
0.1 3.1 GO:0005871 kinesin complex(GO:0005871)
0.0 0.7 GO:0036038 MKS complex(GO:0036038)
0.0 2.1 GO:0000791 euchromatin(GO:0000791)
0.0 4.7 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.7 GO:0042611 MHC protein complex(GO:0042611)
0.0 0.4 GO:0005922 connexon complex(GO:0005922)
0.0 10.7 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.2 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 0.2 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.5 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.2 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 0.1 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.9 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.5 GO:0008180 COP9 signalosome(GO:0008180)
0.0 1.0 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.3 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.7 5.3 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.5 2.1 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.5 1.5 GO:0000402 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)
0.3 1.3 GO:0034618 arginine binding(GO:0034618)
0.3 2.7 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.2 2.9 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.2 0.6 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.2 1.0 GO:0042731 PH domain binding(GO:0042731)
0.2 1.7 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.2 3.8 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.1 0.7 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 0.8 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.1 0.9 GO:0032184 SUMO polymer binding(GO:0032184)
0.1 0.9 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 3.1 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 1.0 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 1.1 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.1 0.5 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.1 0.5 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.1 0.5 GO:0051525 NFAT protein binding(GO:0051525)
0.1 0.3 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.1 0.3 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.1 2.1 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.1 0.8 GO:0070569 pyrimidine ribonucleotide binding(GO:0032557) uridylyltransferase activity(GO:0070569)
0.1 2.3 GO:0071837 HMG box domain binding(GO:0071837)
0.1 1.0 GO:0017166 vinculin binding(GO:0017166)
0.1 1.4 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 0.4 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.1 0.2 GO:0004832 valine-tRNA ligase activity(GO:0004832)
0.0 0.9 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 9.7 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.7 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 1.1 GO:0042169 SH2 domain binding(GO:0042169)
0.0 0.7 GO:0042605 peptide antigen binding(GO:0042605)
0.0 0.2 GO:0016151 nickel cation binding(GO:0016151)
0.0 0.3 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.0 0.4 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.3 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.9 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.3 GO:0005542 folic acid binding(GO:0005542)
0.0 0.1 GO:0015037 peptide disulfide oxidoreductase activity(GO:0015037)
0.0 1.0 GO:0033613 activating transcription factor binding(GO:0033613)
0.0 0.9 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.9 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 2.7 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.1 2.9 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 1.5 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 2.4 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 0.9 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.5 PID_BARD1_PATHWAY BARD1 signaling events
0.0 0.8 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 1.1 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 1.0 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 1.0 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.5 PID_MYC_PATHWAY C-MYC pathway
0.0 1.5 PID_RHOA_REG_PATHWAY Regulation of RhoA activity

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 9.4 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.1 3.8 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.1 2.9 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 0.3 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.1 1.5 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 0.8 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 0.8 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.1 1.9 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 1.5 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
0.0 1.8 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex
0.0 1.4 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.6 REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.5 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.0 0.3 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.2 REACTOME_ACYL_CHAIN_REMODELLING_OF_PG Genes involved in Acyl chain remodelling of PG
0.0 2.7 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.0 0.6 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 1.0 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.2 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.0 0.7 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes