Motif ID: Foxd2

Z-value: 1.021


Transcription factors associated with Foxd2:

Gene SymbolEntrez IDGene Name
Foxd2 ENSMUSG00000055210.3 Foxd2



Activity profile for motif Foxd2.

activity profile for motif Foxd2


Sorted Z-values histogram for motif Foxd2

Sorted Z-values for motif Foxd2



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxd2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_104114088 8.786 ENSMUST00000031249.3
Sparcl1
SPARC-like 1
chr3_+_89520152 8.735 ENSMUST00000000811.7
Kcnn3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr16_+_43508118 8.126 ENSMUST00000114690.1
Zbtb20
zinc finger and BTB domain containing 20
chr14_+_101840602 7.639 ENSMUST00000159314.1
Lmo7
LIM domain only 7
chr10_+_67096456 6.843 ENSMUST00000174317.1
Jmjd1c
jumonji domain containing 1C
chr18_+_37504264 6.678 ENSMUST00000052179.6
Pcdhb20
protocadherin beta 20
chr14_+_101840501 6.407 ENSMUST00000159026.1
Lmo7
LIM domain only 7
chr14_-_30353468 6.159 ENSMUST00000112249.1
Cacna1d
calcium channel, voltage-dependent, L type, alpha 1D subunit
chrX_-_105929206 5.808 ENSMUST00000134381.1
ENSMUST00000154866.1
Atrx

alpha thalassemia/mental retardation syndrome X-linked homolog (human)

chr14_+_80000292 5.579 ENSMUST00000088735.3
Olfm4
olfactomedin 4
chrX_-_105929333 5.465 ENSMUST00000134507.1
ENSMUST00000137453.1
ENSMUST00000150914.1
Atrx


alpha thalassemia/mental retardation syndrome X-linked homolog (human)


chr7_-_61982348 5.063 ENSMUST00000181804.1
ENSMUST00000181187.1
A330076H08Rik

RIKEN cDNA A330076H08 gene

chr16_+_43235856 4.956 ENSMUST00000146708.1
Zbtb20
zinc finger and BTB domain containing 20
chr18_+_37513652 4.823 ENSMUST00000061405.4
Pcdhb21
protocadherin beta 21
chr13_-_97747373 4.540 ENSMUST00000123535.1
5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr1_-_157256682 4.270 ENSMUST00000134543.1
Rasal2
RAS protein activator like 2
chr7_-_61982290 4.138 ENSMUST00000180481.1
A330076H08Rik
RIKEN cDNA A330076H08 gene
chrX_+_159697308 3.966 ENSMUST00000123433.1
Sh3kbp1
SH3-domain kinase binding protein 1
chrX_-_105929397 3.510 ENSMUST00000113573.1
ENSMUST00000130980.1
Atrx

alpha thalassemia/mental retardation syndrome X-linked homolog (human)

chr19_+_26748268 3.216 ENSMUST00000175791.1
ENSMUST00000176698.1
ENSMUST00000177252.1
ENSMUST00000176475.1
ENSMUST00000112637.2
Smarca2




SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2




chr17_-_35046726 3.140 ENSMUST00000097338.4
Msh5
mutS homolog 5 (E. coli)
chr1_-_165934900 3.130 ENSMUST00000069609.5
ENSMUST00000111427.2
ENSMUST00000111426.4
Pou2f1


POU domain, class 2, transcription factor 1


chr2_-_45110336 2.910 ENSMUST00000028229.6
ENSMUST00000152232.1
Zeb2

zinc finger E-box binding homeobox 2

chr2_-_62483637 2.894 ENSMUST00000136686.1
ENSMUST00000102733.3
Gcg

glucagon

chr15_+_3270767 2.846 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
Sepp1



selenoprotein P, plasma, 1



chr13_+_16014457 2.800 ENSMUST00000164993.1
Inhba
inhibin beta-A
chr16_-_16527364 2.748 ENSMUST00000069284.7
Fgd4
FYVE, RhoGEF and PH domain containing 4
chr5_+_107497762 2.650 ENSMUST00000152474.1
ENSMUST00000060553.7
A830010M20Rik

RIKEN cDNA A830010M20 gene

chr15_+_92597104 2.608 ENSMUST00000035399.8
Pdzrn4
PDZ domain containing RING finger 4
chr11_+_97801917 2.607 ENSMUST00000127033.2
Lasp1
LIM and SH3 protein 1
chr1_-_170867761 2.604 ENSMUST00000027974.6
Atf6
activating transcription factor 6
chr13_+_83732438 2.545 ENSMUST00000182701.1
C130071C03Rik
RIKEN cDNA C130071C03 gene
chr6_+_136518820 2.518 ENSMUST00000032335.6
Atf7ip
activating transcription factor 7 interacting protein
chr6_+_13069758 2.425 ENSMUST00000124234.1
ENSMUST00000142211.1
ENSMUST00000031556.7
Tmem106b


transmembrane protein 106B


chr9_-_89092835 2.396 ENSMUST00000167113.1
Trim43b
tripartite motif-containing 43B
chr18_+_51117754 2.385 ENSMUST00000116639.2
Prr16
proline rich 16
chr12_+_103434211 2.251 ENSMUST00000079294.5
ENSMUST00000076788.5
ENSMUST00000076702.5
ENSMUST00000066701.6
ENSMUST00000085065.5
ENSMUST00000140838.1
Ifi27





interferon, alpha-inducible protein 27





chr5_+_107497718 2.219 ENSMUST00000112671.2
A830010M20Rik
RIKEN cDNA A830010M20 gene
chr5_-_103100054 2.070 ENSMUST00000112848.1
Mapk10
mitogen-activated protein kinase 10
chr9_-_20879718 2.036 ENSMUST00000043726.6
Angptl6
angiopoietin-like 6
chr10_-_128744014 1.951 ENSMUST00000026414.7
Dgka
diacylglycerol kinase, alpha
chr2_-_160619971 1.932 ENSMUST00000109473.1
Gm14221
predicted gene 14221
chr2_-_122702615 1.854 ENSMUST00000005952.4
ENSMUST00000099457.3
Slc30a4

solute carrier family 30 (zinc transporter), member 4

chr14_-_52213379 1.799 ENSMUST00000140603.1
Chd8
chromodomain helicase DNA binding protein 8
chr2_+_120977017 1.722 ENSMUST00000067582.7
Tmem62
transmembrane protein 62
chr11_-_69369377 1.702 ENSMUST00000092971.6
ENSMUST00000108661.1
Chd3

chromodomain helicase DNA binding protein 3

chr18_+_37725706 1.677 ENSMUST00000066149.6
Pcdhga9
protocadherin gamma subfamily A, 9
chr2_-_73312701 1.677 ENSMUST00000058615.9
Cir1
corepressor interacting with RBPJ, 1
chr9_+_54980880 1.672 ENSMUST00000093844.3
Chrna5
cholinergic receptor, nicotinic, alpha polypeptide 5
chr18_+_37674303 1.624 ENSMUST00000073447.5
Pcdhga9
protocadherin gamma subfamily A, 9
chr9_-_95750335 1.576 ENSMUST00000053785.3
Trpc1
transient receptor potential cation channel, subfamily C, member 1
chr4_-_82850721 1.563 ENSMUST00000139401.1
Zdhhc21
zinc finger, DHHC domain containing 21
chr7_-_14562171 1.538 ENSMUST00000181796.1
Vmn1r90
vomeronasal 1 receptor 90
chr9_+_14276301 1.525 ENSMUST00000034507.7
Sesn3
sestrin 3
chr8_-_123754138 1.524 ENSMUST00000181805.1
4732419C18Rik
RIKEN cDNA 4732419C18 gene
chr16_-_4880284 1.509 ENSMUST00000037843.6
Ubald1
UBA-like domain containing 1
chr19_-_29753600 1.490 ENSMUST00000175764.1
9930021J03Rik
RIKEN cDNA 9930021J03 gene
chr12_-_101958148 1.386 ENSMUST00000159883.1
ENSMUST00000160251.1
ENSMUST00000161011.1
ENSMUST00000021606.5
Atxn3



ataxin 3



chr6_+_61180313 1.307 ENSMUST00000126214.1
Ccser1
coiled-coil serine rich 1
chr2_+_125136692 1.222 ENSMUST00000099452.2
Ctxn2
cortexin 2
chr17_-_56276750 1.217 ENSMUST00000058136.8
Ticam1
toll-like receptor adaptor molecule 1
chr1_-_57970032 1.151 ENSMUST00000159826.1
Kctd18
potassium channel tetramerisation domain containing 18
chr9_+_78109188 1.129 ENSMUST00000118869.1
ENSMUST00000125615.1
Ick

intestinal cell kinase

chr6_-_54972603 1.120 ENSMUST00000060655.8
Nod1
nucleotide-binding oligomerization domain containing 1
chr7_-_87493371 1.076 ENSMUST00000004770.5
Tyr
tyrosinase
chr1_-_132367879 0.954 ENSMUST00000142609.1
Tmcc2
transmembrane and coiled-coil domains 2
chr9_+_96258697 0.942 ENSMUST00000179416.1
Tfdp2
transcription factor Dp 2
chr1_+_171840607 0.939 ENSMUST00000136479.1
ENSMUST00000042302.6
Cd84

CD84 antigen

chr4_+_150087365 0.922 ENSMUST00000094451.3
Gpr157
G protein-coupled receptor 157
chr9_-_55283582 0.893 ENSMUST00000114306.1
ENSMUST00000164721.1
Nrg4

neuregulin 4

chr15_-_98607611 0.861 ENSMUST00000096224.4
Adcy6
adenylate cyclase 6
chr3_+_76075583 0.860 ENSMUST00000160261.1
Fstl5
follistatin-like 5
chr6_+_77242644 0.823 ENSMUST00000159616.1
Lrrtm1
leucine rich repeat transmembrane neuronal 1
chr1_-_57970104 0.767 ENSMUST00000114410.3
Kctd18
potassium channel tetramerisation domain containing 18
chr10_-_89621253 0.734 ENSMUST00000020102.7
Slc17a8
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8
chr9_-_78109020 0.711 ENSMUST00000001402.7
Fbxo9
f-box protein 9
chr6_+_77242715 0.697 ENSMUST00000161677.1
Lrrtm1
leucine rich repeat transmembrane neuronal 1
chr10_-_19011948 0.678 ENSMUST00000105527.1
Tnfaip3
tumor necrosis factor, alpha-induced protein 3
chr18_-_6516089 0.659 ENSMUST00000115870.2
Epc1
enhancer of polycomb homolog 1 (Drosophila)
chr15_+_100154379 0.658 ENSMUST00000023768.6
ENSMUST00000108971.2
Dip2b

DIP2 disco-interacting protein 2 homolog B (Drosophila)

chr9_-_50555170 0.613 ENSMUST00000119103.1
Bco2
beta-carotene oxygenase 2
chr4_-_136898803 0.613 ENSMUST00000046285.5
C1qa
complement component 1, q subcomponent, alpha polypeptide
chr17_-_78418083 0.600 ENSMUST00000070039.7
ENSMUST00000112487.1
Fez2

fasciculation and elongation protein zeta 2 (zygin II)

chr1_-_126830632 0.588 ENSMUST00000112583.1
ENSMUST00000094609.3
Nckap5

NCK-associated protein 5

chr1_-_126830786 0.548 ENSMUST00000162646.1
Nckap5
NCK-associated protein 5
chr11_+_43682038 0.496 ENSMUST00000094294.4
Pwwp2a
PWWP domain containing 2A
chr9_-_90270712 0.484 ENSMUST00000041767.7
ENSMUST00000144348.1
Tbc1d2b

TBC1 domain family, member 2B

chr1_+_172698046 0.461 ENSMUST00000038495.3
Crp
C-reactive protein, pentraxin-related
chr7_-_127195875 0.426 ENSMUST00000035771.3
ENSMUST00000166791.1
Cd2bp2

CD2 antigen (cytoplasmic tail) binding protein 2

chr1_-_37496095 0.407 ENSMUST00000148047.1
ENSMUST00000143636.1
Mgat4a

mannoside acetylglucosaminyltransferase 4, isoenzyme A

chr11_+_75650501 0.394 ENSMUST00000102505.3
Myo1c
myosin IC
chr9_+_105642957 0.289 ENSMUST00000065778.6
Pik3r4
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 4, p150
chr5_+_24393640 0.288 ENSMUST00000138168.1
ENSMUST00000115077.1
Abcb8

ATP-binding cassette, sub-family B (MDR/TAP), member 8

chr14_-_45388772 0.276 ENSMUST00000046191.7
Gnpnat1
glucosamine-phosphate N-acetyltransferase 1
chr4_+_115737738 0.205 ENSMUST00000106525.2
Efcab14
EF-hand calcium binding domain 14
chr4_+_32243733 0.193 ENSMUST00000165661.1
D130062J21Rik
RIKEN cDNA D130062J21 gene
chr15_+_78935177 0.185 ENSMUST00000145157.1
ENSMUST00000123013.1
Nol12

nucleolar protein 12

chr5_-_31295862 0.176 ENSMUST00000041266.7
ENSMUST00000172435.1
Fndc4

fibronectin type III domain containing 4

chr1_-_118311132 0.175 ENSMUST00000027623.7
Tsn
translin
chr19_+_57452900 0.164 ENSMUST00000026073.6
ENSMUST00000026072.3
Trub1

TruB pseudouridine (psi) synthase homolog 1 (E. coli)

chr4_+_115737754 0.134 ENSMUST00000106522.2
Efcab14
EF-hand calcium binding domain 14
chr6_+_11926758 0.130 ENSMUST00000133776.1
Phf14
PHD finger protein 14
chr8_+_46739745 0.097 ENSMUST00000034041.7
Irf2
interferon regulatory factor 2
chr5_-_88675190 0.077 ENSMUST00000133532.1
ENSMUST00000150438.1
Grsf1

G-rich RNA sequence binding factor 1

chr7_+_43634718 0.072 ENSMUST00000032663.8
Ceacam18
carcinoembryonic antigen-related cell adhesion molecule 18
chr7_-_99980431 0.062 ENSMUST00000080817.4
Rnf169
ring finger protein 169
chr2_+_164832881 0.042 ENSMUST00000103092.1
ENSMUST00000151493.1
ENSMUST00000127650.1
Ctsa


cathepsin A


chr15_+_99393574 0.002 ENSMUST00000162624.1
Tmbim6
transmembrane BAX inhibitor motif containing 6

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.7 14.8 GO:0097393 post-embryonic appendage morphogenesis(GO:0035120) post-embryonic limb morphogenesis(GO:0035127) post-embryonic forelimb morphogenesis(GO:0035128) telomeric repeat-containing RNA transcription(GO:0097393) telomeric repeat-containing RNA transcription from RNA pol II promoter(GO:0097394) regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901580) negative regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901581) positive regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901582)
1.5 6.2 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
1.0 6.8 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.6 3.1 GO:0051026 chiasma assembly(GO:0051026)
0.6 2.8 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.5 2.9 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.4 3.1 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.4 2.9 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072366)
0.4 1.2 GO:0045359 positive regulation of interferon-beta biosynthetic process(GO:0045359)
0.4 3.2 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.3 2.1 GO:0007258 JUN phosphorylation(GO:0007258)
0.3 13.1 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.3 0.9 GO:2001180 negative regulation of interleukin-18 production(GO:0032701) negative regulation of interleukin-10 secretion(GO:2001180)
0.3 2.7 GO:0030035 microspike assembly(GO:0030035)
0.2 0.7 GO:0070428 granuloma formation(GO:0002432) negative regulation of toll-like receptor 3 signaling pathway(GO:0034140) toll-like receptor 5 signaling pathway(GO:0034146) regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428) regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070432)
0.2 1.1 GO:0035720 intraciliary anterograde transport(GO:0035720)
0.2 1.1 GO:0042228 positive regulation of dendritic cell antigen processing and presentation(GO:0002606) detection of bacterium(GO:0016045) interleukin-8 biosynthetic process(GO:0042228) detection of other organism(GO:0098543)
0.2 2.6 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.2 0.9 GO:0035811 negative regulation of urine volume(GO:0035811)
0.2 1.9 GO:0061088 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.2 1.7 GO:0035095 behavioral response to nicotine(GO:0035095)
0.2 1.6 GO:0046541 saliva secretion(GO:0046541)
0.2 1.5 GO:0038203 TORC2 signaling(GO:0038203)
0.2 1.8 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.2 2.0 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.1 2.5 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.1 1.6 GO:0048733 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231) sebaceous gland development(GO:0048733)
0.1 1.4 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.1 2.4 GO:0045793 positive regulation of cell size(GO:0045793)
0.1 4.9 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1 0.6 GO:0008300 isoprenoid catabolic process(GO:0008300)
0.1 0.4 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.1 0.9 GO:0060019 radial glial cell differentiation(GO:0060019)
0.1 0.5 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.1 13.0 GO:0007416 synapse assembly(GO:0007416)
0.1 4.3 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)
0.1 6.3 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.1 1.1 GO:0042438 melanin biosynthetic process(GO:0042438)
0.1 0.3 GO:0006041 glucosamine metabolic process(GO:0006041)
0.0 0.3 GO:0030242 pexophagy(GO:0030242)
0.0 2.3 GO:0046825 regulation of protein export from nucleus(GO:0046825)
0.0 0.1 GO:0035790 platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790)
0.0 2.4 GO:0032418 lysosome localization(GO:0032418)
0.0 0.7 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.6 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 0.2 GO:1990481 mRNA pseudouridine synthesis(GO:1990481)
0.0 0.7 GO:0015813 L-glutamate transport(GO:0015813)
0.0 0.7 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 3.8 GO:0008360 regulation of cell shape(GO:0008360)
0.0 1.0 GO:0042982 amyloid precursor protein metabolic process(GO:0042982)
0.0 0.9 GO:0007606 sensory perception of chemical stimulus(GO:0007606)
0.0 0.2 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)
0.0 1.7 GO:0006333 chromatin assembly or disassembly(GO:0006333)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.7 14.8 GO:1990421 subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707)
0.9 2.8 GO:0043512 inhibin A complex(GO:0043512)
0.6 6.2 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.4 5.6 GO:0042581 specific granule(GO:0042581)
0.3 4.3 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.2 0.7 GO:0097450 astrocyte end-foot(GO:0097450)
0.2 3.2 GO:0071564 npBAF complex(GO:0071564)
0.2 1.2 GO:0097342 ripoptosome(GO:0097342)
0.2 1.7 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 0.7 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 0.4 GO:0045160 myosin I complex(GO:0045160)
0.1 1.5 GO:0061700 GATOR2 complex(GO:0061700)
0.1 13.8 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 11.9 GO:0030175 filopodium(GO:0030175)
0.1 3.1 GO:0000795 synaptonemal complex(GO:0000795)
0.1 0.3 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.1 1.4 GO:0042405 nuclear inclusion body(GO:0042405)
0.1 1.1 GO:0097542 ciliary tip(GO:0097542)
0.1 0.9 GO:0031528 microvillus membrane(GO:0031528)
0.1 1.7 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 2.3 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 1.8 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 1.1 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 2.6 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 1.6 GO:0043034 costamere(GO:0043034)
0.0 4.0 GO:0030139 endocytic vesicle(GO:0030139)
0.0 8.8 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.6 GO:0005581 collagen trimer(GO:0005581)
0.0 4.1 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.9 GO:0060170 ciliary membrane(GO:0060170)
0.0 1.7 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.4 GO:0005682 U5 snRNP(GO:0005682)
0.0 2.4 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 2.1 GO:0043204 perikaryon(GO:0043204)
0.0 2.4 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 2.1 GO:0005770 late endosome(GO:0005770)
0.0 1.1 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 1.5 GO:0045211 postsynaptic membrane(GO:0045211)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 8.7 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
2.1 14.8 GO:0015616 DNA translocase activity(GO:0015616)
0.8 6.2 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.5 2.1 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.5 2.8 GO:0070699 type II activin receptor binding(GO:0070699)
0.4 3.1 GO:0030983 mismatched DNA binding(GO:0030983)
0.4 11.6 GO:0042805 actinin binding(GO:0042805)
0.4 6.8 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.4 1.1 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.3 2.1 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.2 1.1 GO:0050700 CARD domain binding(GO:0050700)
0.2 2.0 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.2 1.7 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.2 8.8 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 0.9 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.1 1.6 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 2.6 GO:0035497 cAMP response element binding(GO:0035497)
0.1 3.1 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.1 2.3 GO:0005521 lamin binding(GO:0005521)
0.1 1.8 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 2.9 GO:0070412 R-SMAD binding(GO:0070412)
0.1 0.4 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1 3.2 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 13.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 0.5 GO:0001849 complement component C1q binding(GO:0001849)
0.1 1.6 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 0.6 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0 2.9 GO:0005179 hormone activity(GO:0005179)
0.0 0.7 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.0 5.7 GO:0051015 actin filament binding(GO:0051015)
0.0 4.0 GO:0017124 SH3 domain binding(GO:0017124)
0.0 4.8 GO:0005096 GTPase activator activity(GO:0005096)
0.0 4.5 GO:0045296 cadherin binding(GO:0045296)
0.0 0.7 GO:0004402 histone acetyltransferase activity(GO:0004402)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 6.0 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 2.8 PID_ALK1_PATHWAY ALK1 signaling events
0.1 2.7 PID_CD40_PATHWAY CD40/CD40L signaling
0.1 0.9 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 4.0 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 0.9 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 1.8 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 3.2 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 1.2 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 5.9 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.3 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 1.0 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 1.8 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.9 PID_E2F_PATHWAY E2F transcription factor network
0.0 1.7 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 0.5 PID_IL6_7_PATHWAY IL6-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.8 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.3 2.6 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.2 1.7 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.2 1.1 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.2 1.2 REACTOME_TRAF6_MEDIATED_INDUCTION_OF_TAK1_COMPLEX Genes involved in TRAF6 mediated induction of TAK1 complex
0.2 2.9 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 3.2 REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.1 4.0 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 3.1 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.1 8.7 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.1 0.9 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 2.0 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 2.3 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 3.1 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.1 1.6 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.0 6.1 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.9 REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 2.7 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 0.7 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.4 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.3 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.3 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis