Motif ID: Ebf3

Z-value: 1.200


Transcription factors associated with Ebf3:

Gene SymbolEntrez IDGene Name
Ebf3 ENSMUSG00000010476.7 Ebf3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ebf3mm10_v2_chr7_-_137314394_137314445-0.508.6e-04Click!


Activity profile for motif Ebf3.

activity profile for motif Ebf3


Sorted Z-values histogram for motif Ebf3

Sorted Z-values for motif Ebf3



Network of associatons between targets according to the STRING database.



First level regulatory network of Ebf3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_66812593 11.761 ENSMUST00000100572.3
Sla
src-like adaptor
chr5_+_117781017 7.595 ENSMUST00000138579.2
Nos1
nitric oxide synthase 1, neuronal
chr1_-_56969827 5.357 ENSMUST00000176759.1
Satb2
special AT-rich sequence binding protein 2
chr1_-_56969864 5.266 ENSMUST00000177424.1
Satb2
special AT-rich sequence binding protein 2
chr7_+_123982799 3.764 ENSMUST00000106437.1
Hs3st4
heparan sulfate (glucosamine) 3-O-sulfotransferase 4
chr4_-_129121234 3.695 ENSMUST00000030572.3
Hpca
hippocalcin
chr2_-_118703963 3.564 ENSMUST00000104937.1
Ankrd63
ankyrin repeat domain 63
chr11_+_104231465 3.215 ENSMUST00000145227.1
Mapt
microtubule-associated protein tau
chr11_+_104231573 3.206 ENSMUST00000132977.1
ENSMUST00000132245.1
ENSMUST00000100347.4
Mapt


microtubule-associated protein tau


chr4_-_129121699 3.117 ENSMUST00000135763.1
ENSMUST00000149763.1
ENSMUST00000164649.1
Hpca


hippocalcin


chr9_+_89909775 3.073 ENSMUST00000034912.4
ENSMUST00000034909.4
Rasgrf1

RAS protein-specific guanine nucleotide-releasing factor 1

chr11_+_104231515 2.962 ENSMUST00000106993.3
Mapt
microtubule-associated protein tau
chr1_-_154725920 2.949 ENSMUST00000004214.8
Cacna1e
calcium channel, voltage-dependent, R type, alpha 1E subunit
chr15_-_98677451 2.833 ENSMUST00000120997.1
ENSMUST00000109149.2
ENSMUST00000003451.4
Rnd1


Rho family GTPase 1


chr15_+_99224976 2.813 ENSMUST00000041415.3
Kcnh3
potassium voltage-gated channel, subfamily H (eag-related), member 3
chr1_-_193370260 2.732 ENSMUST00000016323.4
Camk1g
calcium/calmodulin-dependent protein kinase I gamma
chr5_-_139130159 2.732 ENSMUST00000129851.1
Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr3_+_26331150 2.730 ENSMUST00000099182.2
A830092H15Rik
RIKEN cDNA A830092H15 gene
chr1_-_193370225 2.693 ENSMUST00000169907.1
Camk1g
calcium/calmodulin-dependent protein kinase I gamma
chr1_+_75400070 2.617 ENSMUST00000113589.1
Speg
SPEG complex locus
chr15_-_45114926 2.578 ENSMUST00000022967.5
Kcnv1
potassium channel, subfamily V, member 1
chr7_+_27607997 2.439 ENSMUST00000142365.1
Akt2
thymoma viral proto-oncogene 2
chr3_-_107760221 2.432 ENSMUST00000153114.1
ENSMUST00000118593.1
ENSMUST00000120243.1
Csf1


colony stimulating factor 1 (macrophage)


chr5_-_139129662 2.374 ENSMUST00000026973.7
Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr7_+_27607748 2.338 ENSMUST00000136962.1
Akt2
thymoma viral proto-oncogene 2
chr19_+_43440404 2.320 ENSMUST00000165311.1
Cnnm1
cyclin M1
chr8_+_70493156 2.240 ENSMUST00000008032.7
Crlf1
cytokine receptor-like factor 1
chr11_+_104231390 2.236 ENSMUST00000106992.3
Mapt
microtubule-associated protein tau
chr6_-_32588192 2.207 ENSMUST00000115096.2
Plxna4
plexin A4
chr5_+_30711849 2.174 ENSMUST00000088081.4
ENSMUST00000101442.3
Dpysl5

dihydropyrimidinase-like 5

chr13_+_54949388 2.133 ENSMUST00000026994.7
ENSMUST00000109994.2
Unc5a

unc-5 homolog A (C. elegans)

chr5_+_30711564 2.123 ENSMUST00000114729.1
Dpysl5
dihydropyrimidinase-like 5
chr18_-_43393346 2.117 ENSMUST00000025379.7
Dpysl3
dihydropyrimidinase-like 3
chr14_-_64455903 1.998 ENSMUST00000067927.7
Msra
methionine sulfoxide reductase A
chr3_+_68494208 1.949 ENSMUST00000182719.1
Schip1
schwannomin interacting protein 1
chr4_-_149676043 1.920 ENSMUST00000118704.1
Pik3cd
phosphatidylinositol 3-kinase catalytic delta polypeptide
chr2_-_93462386 1.891 ENSMUST00000123565.1
ENSMUST00000099696.1
Cd82

CD82 antigen

chr6_+_58831748 1.854 ENSMUST00000126292.1
ENSMUST00000031823.5
Herc3

hect domain and RLD 3

chr2_+_170731807 1.842 ENSMUST00000029075.4
Dok5
docking protein 5
chr11_+_75650501 1.839 ENSMUST00000102505.3
Myo1c
myosin IC
chr14_-_60086832 1.787 ENSMUST00000080368.5
Atp8a2
ATPase, aminophospholipid transporter-like, class I, type 8A, member 2
chr2_-_93462457 1.730 ENSMUST00000028644.4
Cd82
CD82 antigen
chr9_-_58313189 1.728 ENSMUST00000061799.8
Loxl1
lysyl oxidase-like 1
chr19_+_5740885 1.684 ENSMUST00000081496.5
Ltbp3
latent transforming growth factor beta binding protein 3
chr11_-_98329641 1.639 ENSMUST00000041685.6
Neurod2
neurogenic differentiation 2
chr7_-_4546567 1.631 ENSMUST00000065957.5
Syt5
synaptotagmin V
chr4_+_137681663 1.620 ENSMUST00000047243.5
Rap1gap
Rap1 GTPase-activating protein
chr4_-_148130678 1.561 ENSMUST00000030862.4
Draxin
dorsal inhibitory axon guidance protein
chr10_+_80299084 1.545 ENSMUST00000154212.1
Apc2
adenomatosis polyposis coli 2
chr7_-_68749170 1.441 ENSMUST00000118110.1
ENSMUST00000048068.7
Arrdc4

arrestin domain containing 4

chr9_-_44288131 1.436 ENSMUST00000160384.1
Abcg4
ATP-binding cassette, sub-family G (WHITE), member 4
chr6_-_119848093 1.413 ENSMUST00000079582.4
Erc1
ELKS/RAB6-interacting/CAST family member 1
chr2_+_55437100 1.376 ENSMUST00000112633.2
ENSMUST00000112632.1
Kcnj3

potassium inwardly-rectifying channel, subfamily J, member 3

chr19_+_38481057 1.361 ENSMUST00000182481.1
Plce1
phospholipase C, epsilon 1
chr3_+_93555080 1.347 ENSMUST00000045756.7
S100a10
S100 calcium binding protein A10 (calpactin)
chr15_+_82256023 1.308 ENSMUST00000143238.1
1500009C09Rik
RIKEN cDNA 1500009C09 gene
chr11_+_75733037 1.307 ENSMUST00000131398.1
Ywhae
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
chr1_-_173367638 1.296 ENSMUST00000005470.4
ENSMUST00000111220.1
Cadm3

cell adhesion molecule 3

chr19_+_37550397 1.291 ENSMUST00000066439.6
Exoc6
exocyst complex component 6
chr5_+_37245792 1.287 ENSMUST00000031004.7
Crmp1
collapsin response mediator protein 1
chr11_+_101246960 1.269 ENSMUST00000107282.3
Ramp2
receptor (calcitonin) activity modifying protein 2
chr6_-_119848059 1.267 ENSMUST00000184864.1
Erc1
ELKS/RAB6-interacting/CAST family member 1
chr13_-_49309217 1.263 ENSMUST00000110087.2
Fgd3
FYVE, RhoGEF and PH domain containing 3
chr11_+_97801917 1.257 ENSMUST00000127033.2
Lasp1
LIM and SH3 protein 1
chr5_+_135806859 1.210 ENSMUST00000126232.1
Srrm3
serine/arginine repetitive matrix 3
chr9_-_64022043 1.210 ENSMUST00000041029.5
Smad6
SMAD family member 6
chr4_+_101496648 1.189 ENSMUST00000106930.1
ENSMUST00000154120.1
Dnajc6

DnaJ (Hsp40) homolog, subfamily C, member 6

chr18_-_31447383 1.160 ENSMUST00000025110.3
Syt4
synaptotagmin IV
chr11_+_83409137 1.142 ENSMUST00000021022.3
Rasl10b
RAS-like, family 10, member B
chr5_+_117363513 1.140 ENSMUST00000111959.1
Wsb2
WD repeat and SOCS box-containing 2
chr5_+_141241490 1.135 ENSMUST00000085774.4
Sdk1
sidekick homolog 1 (chicken)
chr9_+_31280525 1.132 ENSMUST00000117389.1
Prdm10
PR domain containing 10
chr10_-_41303171 1.116 ENSMUST00000043814.3
Fig4
FIG4 homolog (S. cerevisiae)
chr19_+_58728887 1.112 ENSMUST00000048644.5
Pnliprp1
pancreatic lipase related protein 1
chr11_-_29825649 1.093 ENSMUST00000104962.1
4931440F15Rik
RIKEN cDNA 4931440F15 gene
chr8_+_94772009 1.088 ENSMUST00000034230.5
Cx3cl1
chemokine (C-X3-C motif) ligand 1
chr9_-_103228420 1.084 ENSMUST00000126359.1
Trf
transferrin
chr2_+_178414512 1.044 ENSMUST00000094251.4
Fam217b
family with sequence similarity 217, member B
chr4_-_155345696 1.000 ENSMUST00000103178.4
Prkcz
protein kinase C, zeta
chr2_+_55435918 0.999 ENSMUST00000067101.3
Kcnj3
potassium inwardly-rectifying channel, subfamily J, member 3
chr19_-_5683873 0.982 ENSMUST00000141577.1
Pcnxl3
pecanex-like 3 (Drosophila)
chr17_+_83706137 0.975 ENSMUST00000112350.1
ENSMUST00000112349.2
ENSMUST00000112352.3
Mta3


metastasis associated 3


chr9_+_54538984 0.972 ENSMUST00000060242.5
ENSMUST00000118413.1
Sh2d7

SH2 domain containing 7

chr12_+_82170016 0.953 ENSMUST00000166429.1
Sipa1l1
signal-induced proliferation-associated 1 like 1
chr13_+_49187485 0.945 ENSMUST00000049022.8
ENSMUST00000120733.1
Ninj1

ninjurin 1

chr11_-_97744659 0.937 ENSMUST00000018691.8
Pip4k2b
phosphatidylinositol-5-phosphate 4-kinase, type II, beta
chr6_-_124464772 0.929 ENSMUST00000008297.4
Clstn3
calsyntenin 3
chr11_+_101246405 0.928 ENSMUST00000122006.1
ENSMUST00000151830.1
Ramp2

receptor (calcitonin) activity modifying protein 2

chr4_-_133756769 0.924 ENSMUST00000008024.6
Arid1a
AT rich interactive domain 1A (SWI-like)
chr7_-_45510315 0.919 ENSMUST00000131589.1
ENSMUST00000132875.1
Nucb1

nucleobindin 1

chr11_+_83409655 0.915 ENSMUST00000175848.1
ENSMUST00000108140.3
Rasl10b

RAS-like, family 10, member B

chr18_+_51117754 0.898 ENSMUST00000116639.2
Prr16
proline rich 16
chr17_+_83706170 0.888 ENSMUST00000067826.8
Mta3
metastasis associated 3
chr9_+_121366958 0.887 ENSMUST00000045903.6
Trak1
trafficking protein, kinesin binding 1
chr7_-_100932140 0.887 ENSMUST00000107032.1
Arhgef17
Rho guanine nucleotide exchange factor (GEF) 17
chr15_+_78913916 0.885 ENSMUST00000089378.4
Pdxp
pyridoxal (pyridoxine, vitamin B6) phosphatase
chr11_-_116110211 0.883 ENSMUST00000106441.1
ENSMUST00000021120.5
Trim47

tripartite motif-containing 47

chr19_+_4231899 0.873 ENSMUST00000025773.3
Pold4
polymerase (DNA-directed), delta 4
chr19_+_6364557 0.872 ENSMUST00000155973.1
Sf1
splicing factor 1
chr5_+_125532377 0.871 ENSMUST00000031446.6
Tmem132b
transmembrane protein 132B
chr7_-_4844665 0.868 ENSMUST00000066041.5
ENSMUST00000172377.1
Shisa7

shisa homolog 7 (Xenopus laevis)

chr16_+_21891969 0.865 ENSMUST00000042065.6
Map3k13
mitogen-activated protein kinase kinase kinase 13
chr7_-_79743034 0.865 ENSMUST00000032761.7
Pex11a
peroxisomal biogenesis factor 11 alpha
chr9_+_30942541 0.837 ENSMUST00000068135.6
Adamts8
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 8
chr2_-_128687354 0.835 ENSMUST00000110332.1
ENSMUST00000110333.1
ENSMUST00000014499.3
Anapc1


anaphase promoting complex subunit 1


chr5_-_24601961 0.833 ENSMUST00000030791.7
Smarcd3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr8_+_113635787 0.806 ENSMUST00000035777.8
Mon1b
MON1 homolog b (yeast)
chr11_-_120630126 0.804 ENSMUST00000106180.1
Mafg
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian)
chr11_+_117308135 0.802 ENSMUST00000153668.1
Sept9
septin 9
chrX_-_101419788 0.802 ENSMUST00000117901.1
ENSMUST00000120201.1
ENSMUST00000117637.1
ENSMUST00000134005.1
ENSMUST00000121520.1
Zmym3




zinc finger, MYM-type 3




chr2_+_59612034 0.795 ENSMUST00000112568.1
ENSMUST00000037526.4
Tanc1

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

chr5_+_134099704 0.774 ENSMUST00000016088.8
Gatsl2
GATS protein-like 2
chrX_+_7638674 0.768 ENSMUST00000128890.1
Syp
synaptophysin
chr3_+_97158767 0.762 ENSMUST00000090759.4
Acp6
acid phosphatase 6, lysophosphatidic
chr17_+_47672720 0.758 ENSMUST00000152724.1
Usp49
ubiquitin specific peptidase 49
chr11_-_100527862 0.756 ENSMUST00000107385.1
Acly
ATP citrate lyase
chr18_+_31634374 0.753 ENSMUST00000025109.7
Sap130
Sin3A associated protein
chrX_-_101420348 0.749 ENSMUST00000119699.1
Zmym3
zinc finger, MYM-type 3
chr17_-_6782775 0.738 ENSMUST00000064234.6
Ezr
ezrin
chr5_-_38159457 0.729 ENSMUST00000031009.4
Nsg1
neuron specific gene family member 1
chr17_-_34121944 0.721 ENSMUST00000151986.1
Brd2
bromodomain containing 2
chr18_+_38418946 0.711 ENSMUST00000025293.3
Ndfip1
Nedd4 family interacting protein 1
chr2_+_121956651 0.704 ENSMUST00000110574.1
Ctdspl2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr18_+_31634368 0.701 ENSMUST00000178164.1
Sap130
Sin3A associated protein
chrX_-_101420206 0.686 ENSMUST00000118092.1
Zmym3
zinc finger, MYM-type 3
chr1_-_36709904 0.669 ENSMUST00000043951.3
Actr1b
ARP1 actin-related protein 1B, centractin beta
chr4_+_141147911 0.669 ENSMUST00000030757.9
Fbxo42
F-box protein 42
chr5_+_143363890 0.665 ENSMUST00000010969.8
Grid2ip
glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1
chr11_-_69837781 0.663 ENSMUST00000108634.2
Nlgn2
neuroligin 2
chr4_+_154960915 0.661 ENSMUST00000049621.6
Hes5
hairy and enhancer of split 5 (Drosophila)
chr2_+_91457501 0.653 ENSMUST00000028689.3
Lrp4
low density lipoprotein receptor-related protein 4
chr19_+_46341118 0.645 ENSMUST00000128041.1
Tmem180
transmembrane protein 180
chr8_-_111910171 0.643 ENSMUST00000034430.4
Chst5
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
chr6_-_119848120 0.629 ENSMUST00000183703.1
ENSMUST00000183911.1
Erc1

ELKS/RAB6-interacting/CAST family member 1

chr8_-_104395765 0.613 ENSMUST00000179802.1
Cmtm4
CKLF-like MARVEL transmembrane domain containing 4
chr5_+_76140700 0.603 ENSMUST00000152642.1
ENSMUST00000127278.1
Srd5a3

steroid 5 alpha-reductase 3

chr2_+_154548888 0.603 ENSMUST00000045116.4
ENSMUST00000109709.3
1700003F12Rik

RIKEN cDNA 1700003F12 gene

chr7_+_101378183 0.599 ENSMUST00000084895.5
Arap1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr15_-_100424208 0.593 ENSMUST00000154331.1
Slc11a2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr2_-_28840274 0.586 ENSMUST00000037117.5
ENSMUST00000171404.1
Gtf3c4

general transcription factor IIIC, polypeptide 4

chr11_+_95010277 0.578 ENSMUST00000124735.1
Samd14
sterile alpha motif domain containing 14
chr10_-_127060163 0.577 ENSMUST00000040307.5
March9
membrane-associated ring finger (C3HC4) 9
chr9_-_110743653 0.574 ENSMUST00000166716.1
Pth1r
parathyroid hormone 1 receptor
chr13_+_30659999 0.571 ENSMUST00000091672.6
ENSMUST00000110310.1
ENSMUST00000095914.5
Dusp22


dual specificity phosphatase 22


chr14_-_64949632 0.561 ENSMUST00000176832.1
Hmbox1
homeobox containing 1
chr8_+_71469186 0.555 ENSMUST00000124745.1
ENSMUST00000138892.1
ENSMUST00000147642.1
Dda1


DET1 and DDB1 associated 1


chr1_-_166409773 0.544 ENSMUST00000135673.1
ENSMUST00000079972.6
ENSMUST00000169324.1
ENSMUST00000111411.2
ENSMUST00000128861.1
Pogk




pogo transposable element with KRAB domain




chr11_+_101316200 0.534 ENSMUST00000142640.1
ENSMUST00000019470.7
Psme3

proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki)

chr17_-_32388885 0.521 ENSMUST00000087703.5
ENSMUST00000170603.1
Wiz

widely-interspaced zinc finger motifs

chr2_+_82053222 0.518 ENSMUST00000047527.7
Zfp804a
zinc finger protein 804A
chr11_+_75193783 0.518 ENSMUST00000102514.3
Rtn4rl1
reticulon 4 receptor-like 1
chr14_-_41013753 0.516 ENSMUST00000143143.1
ENSMUST00000128236.1
ENSMUST00000022317.8
ENSMUST00000118466.1
Fam213a



family with sequence similarity 213, member A



chr4_+_152096719 0.513 ENSMUST00000105661.3
ENSMUST00000084115.3
Plekhg5

pleckstrin homology domain containing, family G (with RhoGef domain) member 5

chr2_-_92024502 0.506 ENSMUST00000028663.4
Creb3l1
cAMP responsive element binding protein 3-like 1
chr7_-_45510400 0.501 ENSMUST00000033096.7
Nucb1
nucleobindin 1
chr11_+_63128973 0.500 ENSMUST00000108702.1
Pmp22
peripheral myelin protein 22
chr7_+_45785331 0.490 ENSMUST00000120005.1
ENSMUST00000123585.1
Lmtk3

lemur tyrosine kinase 3

chr9_+_45117813 0.480 ENSMUST00000170998.1
ENSMUST00000093855.3
Scn2b

sodium channel, voltage-gated, type II, beta

chrX_+_56787701 0.478 ENSMUST00000151033.1
Fhl1
four and a half LIM domains 1
chr19_-_47464406 0.472 ENSMUST00000111800.2
ENSMUST00000081619.2
Sh3pxd2a

SH3 and PX domains 2A

chr12_-_109068173 0.471 ENSMUST00000073156.7
Begain
brain-enriched guanylate kinase-associated
chr1_-_57970032 0.469 ENSMUST00000159826.1
Kctd18
potassium channel tetramerisation domain containing 18
chr4_+_114680769 0.465 ENSMUST00000146346.1
Gm12829
predicted gene 12829
chrX_+_73716712 0.464 ENSMUST00000114461.2
Abcd1
ATP-binding cassette, sub-family D (ALD), member 1
chr15_+_86214431 0.456 ENSMUST00000063414.8
Tbc1d22a
TBC1 domain family, member 22a
chr2_+_71786923 0.454 ENSMUST00000112101.1
ENSMUST00000028522.3
Itga6

integrin alpha 6

chr4_-_131821516 0.448 ENSMUST00000097860.2
Ptpru
protein tyrosine phosphatase, receptor type, U
chr7_+_28180272 0.448 ENSMUST00000173223.1
Dyrk1b
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
chr19_+_6363719 0.446 ENSMUST00000113489.1
ENSMUST00000113488.1
Sf1

splicing factor 1

chr9_+_121760000 0.438 ENSMUST00000093772.3
Zfp651
zinc finger protein 651
chr16_+_30065333 0.437 ENSMUST00000023171.7
Hes1
hairy and enhancer of split 1 (Drosophila)
chr17_-_50094277 0.434 ENSMUST00000113195.1
Rftn1
raftlin lipid raft linker 1
chr14_-_62292959 0.421 ENSMUST00000063169.8
Dleu7
deleted in lymphocytic leukemia, 7
chr2_-_32260138 0.419 ENSMUST00000002625.8
Uck1
uridine-cytidine kinase 1
chr11_+_98927785 0.412 ENSMUST00000107474.1
Rara
retinoic acid receptor, alpha
chr18_+_36348739 0.412 ENSMUST00000152804.2
Cystm1
cysteine-rich transmembrane module containing 1
chr7_-_25477607 0.408 ENSMUST00000098669.1
ENSMUST00000098668.1
ENSMUST00000098666.2
Ceacam1


carcinoembryonic antigen-related cell adhesion molecule 1


chr10_+_80151154 0.405 ENSMUST00000146516.1
ENSMUST00000144526.1
Midn

midnolin

chr6_+_56832059 0.402 ENSMUST00000031795.7
Fkbp9
FK506 binding protein 9
chr9_-_103222063 0.402 ENSMUST00000170904.1
Trf
transferrin
chr19_-_10869757 0.396 ENSMUST00000120524.1
ENSMUST00000025645.7
Tmem132a

transmembrane protein 132A

chr1_+_156558844 0.392 ENSMUST00000166172.2
ENSMUST00000027888.6
Abl2

v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene)

chr7_-_44670820 0.387 ENSMUST00000048102.7
Myh14
myosin, heavy polypeptide 14
chr19_-_7483212 0.384 ENSMUST00000088169.5
Rtn3
reticulon 3
chr2_+_127590321 0.383 ENSMUST00000146131.1
Mrps5
mitochondrial ribosomal protein S5
chr15_-_100424092 0.379 ENSMUST00000154676.1
Slc11a2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr5_-_62765618 0.376 ENSMUST00000159470.1
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr11_+_101316917 0.361 ENSMUST00000151385.1
Psme3
proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki)
chr14_-_69805524 0.359 ENSMUST00000022665.2
Rhobtb2
Rho-related BTB domain containing 2
chr10_+_80150448 0.350 ENSMUST00000153477.1
Midn
midnolin
chr2_-_52558539 0.348 ENSMUST00000102760.3
ENSMUST00000102761.2
Cacnb4

calcium channel, voltage-dependent, beta 4 subunit

chr19_-_5610038 0.345 ENSMUST00000113641.2
Kat5
K(lysine) acetyltransferase 5
chr10_+_80329953 0.339 ENSMUST00000105358.1
ENSMUST00000105357.1
ENSMUST00000105354.1
ENSMUST00000105355.1
Reep6



receptor accessory protein 6



chr7_-_24587612 0.326 ENSMUST00000094705.2
Zfp575
zinc finger protein 575
chr1_+_167598450 0.322 ENSMUST00000111386.1
ENSMUST00000111384.1
Rxrg

retinoid X receptor gamma

chr6_+_124663027 0.321 ENSMUST00000004381.7
Lpcat3
lysophosphatidylcholine acyltransferase 3
chr7_+_49975228 0.320 ENSMUST00000107603.1
Nell1
NEL-like 1
chr5_-_120503593 0.316 ENSMUST00000031597.6
Plbd2
phospholipase B domain containing 2
chr1_+_89454769 0.313 ENSMUST00000027521.8
ENSMUST00000074945.5
Agap1

ArfGAP with GTPase domain, ankyrin repeat and PH domain 1

chr19_-_3686549 0.313 ENSMUST00000025856.10
ENSMUST00000176867.1
Lrp5

low density lipoprotein receptor-related protein 5


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 7.6 GO:0099548 drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738) retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by nitric oxide(GO:0099548)
2.3 6.8 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
1.3 13.2 GO:1902474 positive regulation of protein localization to synapse(GO:1902474)
0.8 2.4 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.8 4.8 GO:0097473 cellular response to light intensity(GO:0071484) cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473)
0.7 10.6 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.6 2.9 GO:0090273 regulation of somatostatin secretion(GO:0090273)
0.6 1.7 GO:1902460 transforming growth factor beta activation(GO:0036363) regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.6 2.2 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
0.5 1.1 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
0.5 1.6 GO:2000297 negative regulation of synapse maturation(GO:2000297)
0.5 2.8 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.4 5.1 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.4 1.6 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.4 2.2 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.4 1.8 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.4 2.2 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.4 0.7 GO:0048294 negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.3 2.4 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.3 1.0 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.3 1.3 GO:1904529 regulation of actin filament binding(GO:1904529) regulation of actin binding(GO:1904616)
0.3 1.2 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.3 1.5 GO:1902309 negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.3 0.8 GO:0003219 cardiac right ventricle formation(GO:0003219)
0.3 2.5 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.3 1.9 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
0.3 1.1 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.3 0.8 GO:0019085 early viral transcription(GO:0019085)
0.3 2.1 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.3 0.8 GO:0038003 opioid receptor signaling pathway(GO:0038003) regulation of opioid receptor signaling pathway(GO:2000474)
0.2 0.7 GO:1900041 intestinal D-glucose absorption(GO:0001951) negative regulation of interleukin-2 secretion(GO:1900041) terminal web assembly(GO:1902896)
0.2 0.9 GO:0042822 pyridoxal phosphate metabolic process(GO:0042822)
0.2 0.6 GO:0016095 polyprenol catabolic process(GO:0016095)
0.2 1.0 GO:2000551 regulation of T-helper 2 cell cytokine production(GO:2000551) positive regulation of T-helper 2 cell cytokine production(GO:2000553)
0.2 1.2 GO:0072318 clathrin coat disassembly(GO:0072318)
0.2 1.0 GO:0015692 vanadium ion transport(GO:0015676) lead ion transport(GO:0015692)
0.2 1.5 GO:0070447 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447)
0.2 3.3 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.2 3.1 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.2 1.4 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.2 0.9 GO:0006344 maintenance of chromatin silencing(GO:0006344)
0.2 0.8 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.1 1.6 GO:0033327 Leydig cell differentiation(GO:0033327)
0.1 10.3 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.1 0.9 GO:0016557 peroxisome membrane biogenesis(GO:0016557) regulation of peroxisome size(GO:0044375)
0.1 0.4 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.1 0.4 GO:2001187 natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.1 1.8 GO:0001765 membrane raft assembly(GO:0001765)
0.1 0.8 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.1 1.1 GO:0031642 negative regulation of myelination(GO:0031642)
0.1 1.8 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.1 1.9 GO:0001553 luteinization(GO:0001553)
0.1 0.5 GO:0070278 extracellular matrix constituent secretion(GO:0070278)
0.1 0.9 GO:0019896 axonal transport of mitochondrion(GO:0019896)
0.1 0.5 GO:1902775 mitochondrial large ribosomal subunit assembly(GO:1902775)
0.1 1.5 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.1 2.1 GO:0051764 actin crosslink formation(GO:0051764)
0.1 0.5 GO:0046684 response to pyrethroid(GO:0046684)
0.1 0.5 GO:0072675 osteoclast fusion(GO:0072675)
0.1 0.9 GO:2000786 positive regulation of autophagosome assembly(GO:2000786)
0.1 2.1 GO:0001990 regulation of systemic arterial blood pressure by hormone(GO:0001990)
0.1 0.3 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.1 0.5 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.1 0.4 GO:0008655 pyrimidine-containing compound salvage(GO:0008655) pyrimidine nucleoside salvage(GO:0043097)
0.1 0.6 GO:0002710 negative regulation of T cell mediated immunity(GO:0002710)
0.1 0.2 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.1 0.7 GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane(GO:0098887)
0.1 0.2 GO:0006642 triglyceride mobilization(GO:0006642) oncostatin-M-mediated signaling pathway(GO:0038165) regulation of interleukin-6-mediated signaling pathway(GO:0070103) negative regulation of interleukin-6-mediated signaling pathway(GO:0070104)
0.1 1.1 GO:0016322 neuron remodeling(GO:0016322)
0.1 1.9 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971)
0.1 0.2 GO:1990839 response to endothelin(GO:1990839)
0.1 0.1 GO:0021773 striatal medium spiny neuron differentiation(GO:0021773)
0.1 1.2 GO:0021516 dorsal spinal cord development(GO:0021516)
0.1 0.5 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.1 0.3 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
0.1 0.9 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.9 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.2 GO:0042373 vitamin K metabolic process(GO:0042373)
0.0 0.8 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.0 1.6 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.6 GO:0060732 positive regulation of inositol phosphate biosynthetic process(GO:0060732)
0.0 1.1 GO:0048148 behavioral response to cocaine(GO:0048148)
0.0 1.5 GO:0007520 myoblast fusion(GO:0007520)
0.0 1.4 GO:0033344 cholesterol efflux(GO:0033344)
0.0 0.5 GO:0048681 negative regulation of axon regeneration(GO:0048681)
0.0 0.3 GO:0051503 adenine nucleotide transport(GO:0051503)
0.0 5.4 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.0 0.3 GO:0071732 cellular response to nitric oxide(GO:0071732)
0.0 0.8 GO:0052646 alditol phosphate metabolic process(GO:0052646)
0.0 0.9 GO:0000731 DNA synthesis involved in DNA repair(GO:0000731)
0.0 0.5 GO:0097186 amelogenesis(GO:0097186)
0.0 0.9 GO:0042246 tissue regeneration(GO:0042246)
0.0 2.6 GO:0055013 cardiac muscle cell development(GO:0055013)
0.0 0.1 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.0 0.3 GO:0033689 negative regulation of osteoblast proliferation(GO:0033689)
0.0 0.1 GO:0019062 virion attachment to host cell(GO:0019062) adhesion of symbiont to host cell(GO:0044650)
0.0 1.3 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.6 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.0 0.7 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 0.5 GO:0035767 endothelial cell chemotaxis(GO:0035767)
0.0 0.9 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 0.9 GO:0051443 positive regulation of ubiquitin-protein transferase activity(GO:0051443)
0.0 0.3 GO:0032703 negative regulation of interleukin-2 production(GO:0032703)
0.0 0.5 GO:0032288 myelin assembly(GO:0032288)
0.0 0.3 GO:0045792 negative regulation of cell size(GO:0045792)
0.0 0.8 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.3 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.2 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 1.4 GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway(GO:0007200)
0.0 1.3 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.4 GO:0051382 kinetochore assembly(GO:0051382)
0.0 1.0 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 0.2 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 0.2 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.0 0.6 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 0.6 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0 0.1 GO:0010572 positive regulation of platelet activation(GO:0010572)
0.0 0.4 GO:0071625 vocalization behavior(GO:0071625)
0.0 0.1 GO:0097369 sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.7 GO:0060292 long term synaptic depression(GO:0060292)
0.0 0.2 GO:0016486 peptide hormone processing(GO:0016486)
0.0 0.3 GO:0070207 protein homotrimerization(GO:0070207)
0.0 2.0 GO:0007568 aging(GO:0007568)
0.0 0.5 GO:0032212 positive regulation of telomere maintenance via telomerase(GO:0032212)
0.0 0.2 GO:0032292 myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
0.0 0.0 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 0.2 GO:0097435 fibril organization(GO:0097435)
0.0 0.1 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.0 0.1 GO:0007398 ectoderm development(GO:0007398)
0.0 0.4 GO:0030534 adult behavior(GO:0030534)
0.0 0.1 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.0 0.9 GO:2000045 regulation of G1/S transition of mitotic cell cycle(GO:2000045)
0.0 0.1 GO:0007096 regulation of exit from mitosis(GO:0007096)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 11.6 GO:0045298 tubulin complex(GO:0045298)
0.7 2.2 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.7 2.2 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.7 7.6 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.6 1.8 GO:0045160 myosin I complex(GO:0045160)
0.5 6.8 GO:0044327 dendritic spine head(GO:0044327)
0.4 2.2 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.4 1.6 GO:1990769 proximal neuron projection(GO:1990769)
0.4 5.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.3 4.2 GO:0008385 IkappaB kinase complex(GO:0008385)
0.3 0.9 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.3 4.8 GO:0032593 insulin-responsive compartment(GO:0032593)
0.3 0.8 GO:0098592 cytoplasmic side of apical plasma membrane(GO:0098592)
0.2 1.7 GO:0098576 lumenal side of membrane(GO:0098576)
0.2 0.9 GO:0008537 proteasome activator complex(GO:0008537)
0.2 1.0 GO:0070826 paraferritin complex(GO:0070826)
0.2 1.5 GO:0097433 dense body(GO:0097433)
0.2 1.0 GO:0045179 apical cortex(GO:0045179)
0.1 2.7 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 1.5 GO:0016342 catenin complex(GO:0016342)
0.1 9.7 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 1.9 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 1.2 GO:0097449 astrocyte projection(GO:0097449)
0.1 0.7 GO:0016600 flotillin complex(GO:0016600)
0.1 1.5 GO:0071564 npBAF complex(GO:0071564)
0.1 2.6 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 11.9 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 3.3 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 0.6 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.1 0.7 GO:0098845 postsynaptic endosome(GO:0098845)
0.1 0.3 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 0.9 GO:0070938 contractile ring(GO:0070938)
0.1 1.3 GO:0000145 exocyst(GO:0000145)
0.1 2.8 GO:0031941 filamentous actin(GO:0031941)
0.1 0.8 GO:0061700 GATOR2 complex(GO:0061700)
0.1 0.4 GO:0097513 myosin II filament(GO:0097513)
0.1 0.9 GO:1904115 axon cytoplasm(GO:1904115)
0.1 3.6 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.7 GO:0005869 dynactin complex(GO:0005869)
0.0 0.2 GO:0070552 BRISC complex(GO:0070552)
0.0 0.5 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.6 GO:0031105 septin complex(GO:0031105)
0.0 0.7 GO:0097470 ribbon synapse(GO:0097470)
0.0 1.3 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.0 0.4 GO:0042101 T cell receptor complex(GO:0042101)
0.0 1.1 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.0 0.8 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.5 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.3 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.9 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.5 GO:0043218 compact myelin(GO:0043218)
0.0 1.4 GO:0005871 kinesin complex(GO:0005871)
0.0 1.7 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 1.0 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.5 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.3 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 1.1 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.5 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 1.3 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.1 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.5 GO:0002102 podosome(GO:0002102)
0.0 0.2 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.9 GO:0005776 autophagosome(GO:0005776)
0.0 0.3 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 0.4 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 2.8 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 7.6 GO:0004517 nitric-oxide synthase activity(GO:0004517)
1.7 11.6 GO:0099609 microtubule lateral binding(GO:0099609)
0.7 2.0 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.5 2.4 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.5 2.8 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.5 5.1 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.4 2.2 GO:0097643 amylin receptor activity(GO:0097643)
0.4 1.6 GO:0045131 pre-mRNA branch point binding(GO:0045131)
0.4 1.4 GO:0034041 sterol-transporting ATPase activity(GO:0034041)
0.4 2.1 GO:0005042 netrin receptor activity(GO:0005042)
0.4 2.5 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.3 0.9 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.3 11.8 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.3 2.6 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.3 1.2 GO:0030348 syntaxin-3 binding(GO:0030348)
0.2 1.9 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.2 3.3 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.2 1.1 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.2 0.9 GO:0033883 pyridoxal phosphatase activity(GO:0033883)
0.2 0.6 GO:0047751 3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765) enone reductase activity(GO:0035671) cholestenone 5-alpha-reductase activity(GO:0047751)
0.2 1.0 GO:0015086 cadmium ion transmembrane transporter activity(GO:0015086) lead ion transmembrane transporter activity(GO:0015094) vanadium ion transmembrane transporter activity(GO:0015100) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.2 1.2 GO:0070697 activin receptor binding(GO:0070697)
0.2 2.2 GO:0017154 semaphorin receptor activity(GO:0017154)
0.2 1.7 GO:0031005 filamin binding(GO:0031005)
0.1 1.5 GO:0008199 ferric iron binding(GO:0008199)
0.1 2.2 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 0.7 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.1 5.6 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 1.5 GO:0050815 phosphoserine binding(GO:0050815)
0.1 1.7 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.1 0.3 GO:0071936 coreceptor activity involved in Wnt signaling pathway(GO:0071936)
0.1 0.9 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 1.1 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 0.3 GO:0046964 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity(GO:0046964)
0.1 0.7 GO:0032051 clathrin light chain binding(GO:0032051)
0.1 0.5 GO:0038132 neuregulin binding(GO:0038132)
0.1 0.8 GO:0003993 acid phosphatase activity(GO:0003993)
0.1 0.4 GO:0004849 uridine kinase activity(GO:0004849)
0.1 0.5 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.1 0.2 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.1 1.3 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.1 3.9 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.1 1.8 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 0.5 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.1 0.7 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.1 1.8 GO:0005158 insulin receptor binding(GO:0005158)
0.1 5.1 GO:0005080 protein kinase C binding(GO:0005080)
0.1 1.3 GO:0043274 phospholipase binding(GO:0043274)
0.1 0.6 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 0.9 GO:0050811 GABA receptor binding(GO:0050811)
0.1 0.3 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.1 0.3 GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.0 0.2 GO:0004090 carbonyl reductase (NADPH) activity(GO:0004090)
0.0 0.2 GO:0046923 ER retention sequence binding(GO:0046923)
0.0 0.3 GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.0 2.3 GO:0070888 E-box binding(GO:0070888)
0.0 1.8 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.5 GO:0003964 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.0 0.4 GO:0035014 retinoic acid binding(GO:0001972) phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.0 1.6 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.7 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 1.6 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.5 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.8 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 1.1 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 0.8 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 0.7 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.9 GO:0034061 DNA-directed DNA polymerase activity(GO:0003887) DNA polymerase activity(GO:0034061)
0.0 0.1 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.0 0.2 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 2.3 GO:0005125 cytokine activity(GO:0005125)
0.0 0.1 GO:0003996 acyl-CoA ligase activity(GO:0003996)
0.0 3.4 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds(GO:0016810)
0.0 0.2 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.0 0.7 GO:0017046 peptide hormone binding(GO:0017046)
0.0 0.2 GO:0001515 opioid peptide activity(GO:0001515)
0.0 0.3 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 1.0 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.1 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 1.5 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.0 0.4 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.7 GO:0050699 WW domain binding(GO:0050699)
0.0 2.3 GO:0030165 PDZ domain binding(GO:0030165)
0.0 2.2 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.4 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 1.1 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.3 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.1 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 0.7 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 8.9 GO:0003682 chromatin binding(GO:0003682)
0.0 0.1 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 5.5 GO:0003779 actin binding(GO:0003779)
0.0 0.3 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 1.4 GO:0044325 ion channel binding(GO:0044325)
0.0 0.2 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.0 0.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.7 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.0 0.8 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 11.6 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.2 2.4 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.2 6.9 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.1 5.4 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 3.3 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.1 2.0 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 3.3 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.1 2.4 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.1 2.1 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 13.1 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.1 0.4 ST_TYPE_I_INTERFERON_PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.1 0.7 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.0 0.3 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 1.1 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.0 2.7 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.9 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.9 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.0 1.2 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.4 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.3 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 0.6 PID_MYC_PATHWAY C-MYC pathway
0.0 0.2 PID_IL27_PATHWAY IL27-mediated signaling events
0.0 0.4 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.7 PID_CDC42_PATHWAY CDC42 signaling events
0.0 2.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.3 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.3 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 0.4 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.3 PID_PI3KCI_AKT_PATHWAY Class I PI3K signaling events mediated by Akt
0.0 0.8 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.0 2.2 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 0.1 ST_P38_MAPK_PATHWAY p38 MAPK Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 10.6 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.4 2.8 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.4 7.7 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.3 4.8 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.2 6.9 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.2 5.1 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.2 2.1 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.1 5.4 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 0.6 REACTOME_ANDROGEN_BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.1 1.1 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 3.8 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 2.7 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1 0.9 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.1 2.9 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 1.7 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 2.4 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 1.6 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.1 1.3 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 1.5 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.1 1.9 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 2.8 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.8 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 1.1 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 1.0 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.3 REACTOME_ACYL_CHAIN_REMODELLING_OF_PS Genes involved in Acyl chain remodelling of PS
0.0 1.6 REACTOME_REGULATION_OF_INSULIN_SECRETION Genes involved in Regulation of Insulin Secretion
0.0 1.2 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.8 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.6 REACTOME_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.0 0.4 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 0.6 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_2_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.0 0.2 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.7 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.0 0.3 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 0.4 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.5 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.3 REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0 0.1 REACTOME_MEMBRANE_BINDING_AND_TARGETTING_OF_GAG_PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 1.0 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.5 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.2 REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING Genes involved in SHC1 events in EGFR signaling
0.0 0.4 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.8 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK