Motif ID: Nkx6-3_Dbx2_Barx2
Z-value: 0.454



Transcription factors associated with Nkx6-3_Dbx2_Barx2:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Barx2 | ENSMUSG00000032033.10 | Barx2 |
Dbx2 | ENSMUSG00000045608.6 | Dbx2 |
Nkx6-3 | ENSMUSG00000063672.6 | Nkx6-3 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Dbx2 | mm10_v2_chr15_-_95655960_95655960 | 0.36 | 2.2e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 1.1 | GO:0015866 | ADP transport(GO:0015866) |
0.3 | 1.4 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
0.3 | 1.5 | GO:0098735 | cellular response to caffeine(GO:0071313) positive regulation of the force of heart contraction(GO:0098735) |
0.2 | 1.0 | GO:0015788 | UDP-N-acetylglucosamine transport(GO:0015788) |
0.2 | 1.0 | GO:1900170 | negative regulation of glucocorticoid mediated signaling pathway(GO:1900170) |
0.2 | 0.5 | GO:2000564 | antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187) |
0.1 | 0.4 | GO:1903903 | regulation of establishment of T cell polarity(GO:1903903) |
0.1 | 1.7 | GO:1901898 | negative regulation of relaxation of cardiac muscle(GO:1901898) |
0.1 | 0.3 | GO:0072204 | cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204) |
0.1 | 1.6 | GO:0048672 | positive regulation of collateral sprouting(GO:0048672) |
0.1 | 0.4 | GO:0010700 | negative regulation of norepinephrine secretion(GO:0010700) |
0.1 | 0.3 | GO:0038128 | ERBB2 signaling pathway(GO:0038128) |
0.1 | 0.4 | GO:0002457 | T cell antigen processing and presentation(GO:0002457) |
0.1 | 0.8 | GO:0042415 | norepinephrine metabolic process(GO:0042415) |
0.1 | 0.2 | GO:0044028 | DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029) |
0.1 | 1.0 | GO:0033572 | transferrin transport(GO:0033572) |
0.1 | 0.3 | GO:0090472 | dibasic protein processing(GO:0090472) |
0.1 | 0.2 | GO:1902256 | apoptotic process involved in outflow tract morphogenesis(GO:0003275) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256) |
0.1 | 2.8 | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading(GO:1900026) |
0.1 | 0.4 | GO:1901525 | negative regulation of macromitophagy(GO:1901525) regulation of mitophagy in response to mitochondrial depolarization(GO:1904923) |
0.1 | 1.6 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
0.1 | 0.3 | GO:0060690 | epithelial cell differentiation involved in salivary gland development(GO:0060690) |
0.1 | 0.3 | GO:0048630 | skeletal muscle tissue growth(GO:0048630) |
0.1 | 0.6 | GO:0032570 | response to progesterone(GO:0032570) |
0.1 | 0.3 | GO:1903056 | positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056) |
0.1 | 0.4 | GO:0090091 | positive regulation of extracellular matrix disassembly(GO:0090091) negative regulation of wound healing, spreading of epidermal cells(GO:1903690) |
0.1 | 0.2 | GO:0042420 | dopamine catabolic process(GO:0042420) |
0.1 | 0.3 | GO:0090669 | telomerase RNA stabilization(GO:0090669) |
0.0 | 0.4 | GO:1901162 | serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162) |
0.0 | 0.3 | GO:0019532 | oxalate transport(GO:0019532) |
0.0 | 0.2 | GO:0006780 | uroporphyrinogen III biosynthetic process(GO:0006780) |
0.0 | 0.6 | GO:0016486 | peptide hormone processing(GO:0016486) |
0.0 | 0.1 | GO:0009838 | abscission(GO:0009838) |
0.0 | 0.2 | GO:1902995 | regulation of phospholipid efflux(GO:1902994) positive regulation of phospholipid efflux(GO:1902995) positive regulation of apoptotic cell clearance(GO:2000427) |
0.0 | 0.1 | GO:0070560 | protein secretion by platelet(GO:0070560) |
0.0 | 0.1 | GO:0046619 | optic placode formation involved in camera-type eye formation(GO:0046619) |
0.0 | 0.1 | GO:0071596 | ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596) |
0.0 | 0.5 | GO:0051382 | kinetochore assembly(GO:0051382) |
0.0 | 0.8 | GO:0030903 | notochord development(GO:0030903) |
0.0 | 0.2 | GO:0006451 | selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451) |
0.0 | 0.1 | GO:0051012 | microtubule sliding(GO:0051012) negative regulation of nonmotile primary cilium assembly(GO:1902856) |
0.0 | 0.2 | GO:0035372 | protein localization to microtubule(GO:0035372) |
0.0 | 0.1 | GO:0010273 | detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169) |
0.0 | 1.3 | GO:0009063 | cellular amino acid catabolic process(GO:0009063) |
0.0 | 0.2 | GO:0071578 | zinc II ion transmembrane import(GO:0071578) |
0.0 | 0.6 | GO:0071480 | cellular response to gamma radiation(GO:0071480) |
0.0 | 0.1 | GO:0070562 | regulation of vitamin D receptor signaling pathway(GO:0070562) |
0.0 | 0.1 | GO:0006686 | sphingomyelin biosynthetic process(GO:0006686) |
0.0 | 0.1 | GO:0030242 | pexophagy(GO:0030242) |
0.0 | 0.1 | GO:0045743 | positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743) |
0.0 | 0.2 | GO:0031272 | regulation of pseudopodium assembly(GO:0031272) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 0.7 | GO:0097637 | intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637) |
0.2 | 2.8 | GO:0042581 | specific granule(GO:0042581) |
0.1 | 0.4 | GO:0030981 | cortical microtubule cytoskeleton(GO:0030981) |
0.1 | 0.6 | GO:0097524 | sperm plasma membrane(GO:0097524) |
0.1 | 0.2 | GO:0005943 | phosphatidylinositol 3-kinase complex, class IA(GO:0005943) |
0.0 | 0.4 | GO:0031254 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
0.0 | 1.2 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
0.0 | 0.5 | GO:0042612 | MHC class I protein complex(GO:0042612) |
0.0 | 1.6 | GO:0034707 | chloride channel complex(GO:0034707) |
0.0 | 0.3 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
0.0 | 0.3 | GO:0005915 | zonula adherens(GO:0005915) |
0.0 | 0.3 | GO:0031462 | Cul2-RING ubiquitin ligase complex(GO:0031462) |
0.0 | 0.1 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
0.0 | 0.3 | GO:0017119 | Golgi transport complex(GO:0017119) |
0.0 | 1.5 | GO:0014704 | intercalated disc(GO:0014704) |
0.0 | 0.1 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
0.0 | 0.3 | GO:0012510 | trans-Golgi network transport vesicle membrane(GO:0012510) |
0.0 | 0.1 | GO:0035068 | micro-ribonucleoprotein complex(GO:0035068) |
0.0 | 0.1 | GO:0000138 | Golgi trans cisterna(GO:0000138) |
0.0 | 0.5 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
0.0 | 0.1 | GO:0005726 | perichromatin fibrils(GO:0005726) |
0.0 | 0.2 | GO:0031143 | pseudopodium(GO:0031143) |
0.0 | 0.2 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
0.0 | 0.8 | GO:0001669 | acrosomal vesicle(GO:0001669) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 1.3 | GO:0001716 | L-amino-acid oxidase activity(GO:0001716) |
0.4 | 1.5 | GO:0086038 | calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038) |
0.4 | 1.1 | GO:0015228 | coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122) |
0.2 | 1.4 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
0.1 | 0.4 | GO:0004510 | tryptophan 5-monooxygenase activity(GO:0004510) |
0.1 | 0.5 | GO:0019770 | IgG receptor activity(GO:0019770) |
0.1 | 0.7 | GO:0045134 | uridine-diphosphatase activity(GO:0045134) |
0.1 | 1.6 | GO:0004890 | GABA-A receptor activity(GO:0004890) |
0.1 | 1.0 | GO:0008484 | sulfuric ester hydrolase activity(GO:0008484) |
0.1 | 0.2 | GO:0030226 | apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556) |
0.1 | 0.5 | GO:0046703 | natural killer cell lectin-like receptor binding(GO:0046703) |
0.0 | 0.6 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
0.0 | 1.0 | GO:0005351 | sugar:proton symporter activity(GO:0005351) |
0.0 | 0.8 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
0.0 | 0.2 | GO:0051378 | primary amine oxidase activity(GO:0008131) serotonin binding(GO:0051378) |
0.0 | 1.8 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
0.0 | 0.3 | GO:0051880 | G-quadruplex DNA binding(GO:0051880) |
0.0 | 0.3 | GO:0022848 | acetylcholine-gated cation channel activity(GO:0022848) |
0.0 | 1.1 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
0.0 | 0.3 | GO:0019531 | secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531) |
0.0 | 0.2 | GO:0004852 | uroporphyrinogen-III synthase activity(GO:0004852) |
0.0 | 0.1 | GO:0033188 | sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493) |
0.0 | 0.3 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
0.0 | 0.4 | GO:0002162 | dystroglycan binding(GO:0002162) |
0.0 | 0.2 | GO:0035368 | selenocysteine insertion sequence binding(GO:0035368) |
0.0 | 0.2 | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813) |
0.0 | 0.1 | GO:0008273 | calcium, potassium:sodium antiporter activity(GO:0008273) |
0.0 | 0.3 | GO:0048406 | nerve growth factor binding(GO:0048406) |
0.0 | 0.1 | GO:0034235 | GPI anchor binding(GO:0034235) |
0.0 | 0.8 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
0.0 | 0.8 | GO:0005504 | fatty acid binding(GO:0005504) |
0.0 | 0.7 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
0.0 | 0.1 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
0.0 | 0.1 | GO:0008526 | phosphatidylinositol transporter activity(GO:0008526) |
0.0 | 0.1 | GO:0034056 | estrogen response element binding(GO:0034056) |
0.0 | 0.1 | GO:0004984 | olfactory receptor activity(GO:0004984) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 1.8 | PID_ARF6_PATHWAY | Arf6 signaling events |
0.0 | 1.6 | PID_LIS1_PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
0.0 | 0.5 | PID_ECADHERIN_KERATINOCYTE_PATHWAY | E-cadherin signaling in keratinocytes |
0.0 | 0.1 | ST_INTERFERON_GAMMA_PATHWAY | Interferon gamma pathway. |
0.0 | 0.4 | SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 1.0 | REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
0.1 | 1.5 | REACTOME_PLATELET_CALCIUM_HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
0.0 | 0.3 | REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
0.0 | 1.7 | REACTOME_DARPP_32_EVENTS | Genes involved in DARPP-32 events |
0.0 | 0.4 | REACTOME_AMINE_DERIVED_HORMONES | Genes involved in Amine-derived hormones |
0.0 | 0.3 | REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
0.0 | 1.4 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
0.0 | 1.0 | REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
0.0 | 0.5 | REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
0.0 | 0.2 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |