Motif ID: Tfap2d

Z-value: 0.763


Transcription factors associated with Tfap2d:

Gene SymbolEntrez IDGene Name
Tfap2d ENSMUSG00000042596.7 Tfap2d

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap2dmm10_v2_chr1_+_19103022_191030430.251.2e-01Click!


Activity profile for motif Tfap2d.

activity profile for motif Tfap2d


Sorted Z-values histogram for motif Tfap2d

Sorted Z-values for motif Tfap2d



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap2d

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_32222233 4.394 ENSMUST00000150381.1
ENSMUST00000144902.1
ENSMUST00000020524.8
Rhbdf1


rhomboid family 1 (Drosophila)


chr12_+_84009481 3.607 ENSMUST00000168120.1
Acot1
acyl-CoA thioesterase 1
chr18_+_64340225 3.051 ENSMUST00000175965.2
ENSMUST00000115145.3
Onecut2

one cut domain, family member 2

chr8_-_105637350 2.856 ENSMUST00000182863.1
Gm5914
predicted gene 5914
chr2_+_25180737 2.292 ENSMUST00000104999.2
Nrarp
Notch-regulated ankyrin repeat protein
chr4_-_154636831 2.290 ENSMUST00000030902.6
ENSMUST00000105637.1
ENSMUST00000070313.7
ENSMUST00000105636.1
ENSMUST00000105638.2
ENSMUST00000097759.2
ENSMUST00000124771.1
Prdm16






PR domain containing 16






chr4_+_152008803 2.237 ENSMUST00000097773.3
Klhl21
kelch-like 21
chr7_+_130936172 2.199 ENSMUST00000006367.7
Htra1
HtrA serine peptidase 1
chr12_+_83987854 2.188 ENSMUST00000021649.7
Acot2
acyl-CoA thioesterase 2
chr11_-_31370066 2.185 ENSMUST00000020546.2
Stc2
stanniocalcin 2
chr9_-_79718631 1.904 ENSMUST00000180083.1
Col12a1
collagen, type XII, alpha 1
chr2_+_26586607 1.883 ENSMUST00000174211.1
ENSMUST00000145575.2
ENSMUST00000173920.1
Egfl7


EGF-like domain 7


chr19_+_38481057 1.872 ENSMUST00000182481.1
Plce1
phospholipase C, epsilon 1
chr7_-_4789541 1.832 ENSMUST00000168578.1
Tmem238
transmembrane protein 238
chr2_+_91257323 1.726 ENSMUST00000111349.2
ENSMUST00000131711.1
Pacsin3

protein kinase C and casein kinase substrate in neurons 3

chr8_-_105637403 1.712 ENSMUST00000182046.1
Gm5914
predicted gene 5914
chr9_-_79718518 1.710 ENSMUST00000071750.6
Col12a1
collagen, type XII, alpha 1
chr9_-_79718720 1.661 ENSMUST00000121227.1
Col12a1
collagen, type XII, alpha 1
chr2_-_173276144 1.557 ENSMUST00000139306.1
Pmepa1
prostate transmembrane protein, androgen induced 1
chr6_-_134632388 1.522 ENSMUST00000047443.3
Mansc1
MANSC domain containing 1
chr2_+_91945703 1.488 ENSMUST00000178895.1
Gm9821
predicted gene 9821
chr19_+_8929628 1.434 ENSMUST00000096241.4
Eml3
echinoderm microtubule associated protein like 3
chr3_-_104961695 1.413 ENSMUST00000029429.4
Wnt2b
wingless related MMTV integration site 2b
chr3_+_33799791 1.410 ENSMUST00000099153.3
Ttc14
tetratricopeptide repeat domain 14
chr12_-_80112998 1.405 ENSMUST00000165114.1
ENSMUST00000021552.1
Zfp36l1

zinc finger protein 36, C3H type-like 1

chr5_-_71095765 1.393 ENSMUST00000000572.5
Gabra2
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2
chr1_+_74391479 1.371 ENSMUST00000027367.7
Ctdsp1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr19_+_42147373 1.353 ENSMUST00000061111.9
Marveld1
MARVEL (membrane-associating) domain containing 1
chr18_+_24709436 1.235 ENSMUST00000037097.7
Fhod3
formin homology 2 domain containing 3
chr18_-_80986578 1.225 ENSMUST00000057950.7
Sall3
sal-like 3 (Drosophila)
chr17_-_85688252 1.215 ENSMUST00000024947.7
ENSMUST00000163568.2
Six2

sine oculis-related homeobox 2

chr4_-_106464167 1.192 ENSMUST00000049507.5
Pcsk9
proprotein convertase subtilisin/kexin type 9
chr5_+_32611171 1.188 ENSMUST00000072311.6
ENSMUST00000168707.2
Yes1

Yamaguchi sarcoma viral (v-yes) oncogene homolog 1

chr12_+_113098199 1.158 ENSMUST00000009099.6
ENSMUST00000109723.1
ENSMUST00000109726.1
ENSMUST00000109727.2
ENSMUST00000069690.4
Mta1




metastasis associated 1




chr7_-_127708886 1.153 ENSMUST00000061468.8
Bcl7c
B cell CLL/lymphoma 7C
chr5_-_113015473 1.143 ENSMUST00000065167.4
Adrbk2
adrenergic receptor kinase, beta 2
chr2_+_119742306 1.140 ENSMUST00000028758.7
Itpka
inositol 1,4,5-trisphosphate 3-kinase A
chr2_-_173276526 1.133 ENSMUST00000036248.6
Pmepa1
prostate transmembrane protein, androgen induced 1
chr13_-_83729544 1.119 ENSMUST00000181705.1
Gm26803
predicted gene, 26803
chr5_+_129584169 1.110 ENSMUST00000031390.8
Mmp17
matrix metallopeptidase 17
chr2_+_128126030 1.095 ENSMUST00000089634.5
ENSMUST00000019281.7
ENSMUST00000110341.2
ENSMUST00000103211.1
ENSMUST00000103210.1
Bcl2l11




BCL2-like 11 (apoptosis facilitator)




chr13_+_31625802 1.087 ENSMUST00000042054.2
Foxf2
forkhead box F2
chr18_+_84720019 1.086 ENSMUST00000161429.1
ENSMUST00000052501.1
Fam69c

family with sequence similarity 69, member C

chr5_-_124354671 1.072 ENSMUST00000031341.4
Cdk2ap1
CDK2 (cyclin-dependent kinase 2)-associated protein 1
chr8_-_11008458 1.060 ENSMUST00000040514.6
Irs2
insulin receptor substrate 2
chr3_-_87930121 1.049 ENSMUST00000005016.9
Rrnad1
ribosomal RNA adenine dimethylase domain containing 1
chr17_-_79020816 1.026 ENSMUST00000168887.1
ENSMUST00000119284.1
Prkd3

protein kinase D3

chr4_+_129513581 1.011 ENSMUST00000062356.6
Marcksl1
MARCKS-like 1
chr17_-_72603709 0.982 ENSMUST00000086639.4
Alk
anaplastic lymphoma kinase
chr7_+_65862029 0.976 ENSMUST00000055576.5
ENSMUST00000098391.4
Pcsk6

proprotein convertase subtilisin/kexin type 6

chr3_+_33800158 0.940 ENSMUST00000139880.1
ENSMUST00000076916.6
ENSMUST00000142280.1
ENSMUST00000117915.1
ENSMUST00000108210.2
Ttc14




tetratricopeptide repeat domain 14




chr6_+_124996681 0.938 ENSMUST00000032479.4
Pianp
PILR alpha associated neural protein
chr4_+_114406717 0.924 ENSMUST00000094894.3
Trabd2b
TraB domain containing 2B
chr2_+_27677201 0.923 ENSMUST00000077257.5
Rxra
retinoid X receptor alpha
chr6_+_72355425 0.921 ENSMUST00000069695.2
ENSMUST00000132243.1
Tmem150a

transmembrane protein 150A

chr9_+_53384017 0.898 ENSMUST00000037853.3
Kdelc2
KDEL (Lys-Asp-Glu-Leu) containing 2
chr4_+_129985098 0.877 ENSMUST00000106017.1
ENSMUST00000121049.1
Bai2

brain-specific angiogenesis inhibitor 2

chr4_+_46450892 0.875 ENSMUST00000102926.4
Anp32b
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr10_-_42276744 0.864 ENSMUST00000105502.1
ENSMUST00000105501.1
Foxo3

forkhead box O3

chr11_-_69795930 0.857 ENSMUST00000045971.8
Chrnb1
cholinergic receptor, nicotinic, beta polypeptide 1 (muscle)
chr1_+_194938821 0.850 ENSMUST00000016638.2
ENSMUST00000110815.2
Cd34

CD34 antigen

chr11_+_85832551 0.803 ENSMUST00000000095.6
Tbx2
T-box 2
chrX_-_142966709 0.791 ENSMUST00000041317.2
Ammecr1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr4_+_108619925 0.774 ENSMUST00000030320.6
Cc2d1b
coiled-coil and C2 domain containing 1B
chr16_+_17646564 0.767 ENSMUST00000182117.1
ENSMUST00000182671.1
ENSMUST00000182344.1
Ccdc74a


coiled-coil domain containing 74A


chr2_+_4717825 0.754 ENSMUST00000184139.1
ENSMUST00000115022.1
Bend7

BEN domain containing 7

chr2_+_27677234 0.740 ENSMUST00000166775.1
Rxra
retinoid X receptor alpha
chr18_+_35118880 0.739 ENSMUST00000042345.6
Ctnna1
catenin (cadherin associated protein), alpha 1
chr8_-_104395765 0.738 ENSMUST00000179802.1
Cmtm4
CKLF-like MARVEL transmembrane domain containing 4
chr8_-_120228221 0.737 ENSMUST00000183235.1
A330074K22Rik
RIKEN cDNA A330074K22 gene
chr10_-_80399389 0.727 ENSMUST00000105348.1
Mbd3
methyl-CpG binding domain protein 3
chr16_-_38713235 0.721 ENSMUST00000023487.4
Arhgap31
Rho GTPase activating protein 31
chr2_-_32712728 0.717 ENSMUST00000009699.9
Cdk9
cyclin-dependent kinase 9 (CDC2-related kinase)
chr2_-_30359190 0.709 ENSMUST00000100215.4
ENSMUST00000113620.3
Sh3glb2

SH3-domain GRB2-like endophilin B2

chr2_-_30359278 0.683 ENSMUST00000163668.2
ENSMUST00000028214.8
ENSMUST00000113621.3
Sh3glb2


SH3-domain GRB2-like endophilin B2


chr12_-_50649190 0.664 ENSMUST00000002765.7
Prkd1
protein kinase D1
chr11_+_59306920 0.662 ENSMUST00000000128.3
ENSMUST00000108783.3
Wnt9a

wingless-type MMTV integration site 9A

chr15_-_89425856 0.653 ENSMUST00000109313.2
Cpt1b
carnitine palmitoyltransferase 1b, muscle
chr17_+_23803179 0.645 ENSMUST00000088621.4
Srrm2
serine/arginine repetitive matrix 2
chr15_-_58076425 0.644 ENSMUST00000176935.1
9130401M01Rik
RIKEN cDNA 9130401M01 gene
chrX_+_73673150 0.643 ENSMUST00000033752.7
ENSMUST00000114467.2
Slc6a8

solute carrier family 6 (neurotransmitter transporter, creatine), member 8

chr10_-_42276688 0.622 ENSMUST00000175881.1
ENSMUST00000056974.3
Foxo3

forkhead box O3

chr16_+_4639941 0.619 ENSMUST00000038770.3
Vasn
vasorin
chr2_+_4718145 0.618 ENSMUST00000056914.6
Bend7
BEN domain containing 7
chr4_+_84884418 0.610 ENSMUST00000169371.2
Cntln
centlein, centrosomal protein
chr1_-_64737735 0.605 ENSMUST00000063982.5
ENSMUST00000116133.2
Fzd5

frizzled homolog 5 (Drosophila)

chr2_+_167688915 0.602 ENSMUST00000070642.3
Cebpb
CCAAT/enhancer binding protein (C/EBP), beta
chr4_+_84884276 0.594 ENSMUST00000047023.6
Cntln
centlein, centrosomal protein
chr4_+_137993445 0.591 ENSMUST00000105831.2
ENSMUST00000084214.5
Eif4g3

eukaryotic translation initiation factor 4 gamma, 3

chr5_-_76304474 0.585 ENSMUST00000075159.1
Clock
circadian locomotor output cycles kaput
chr15_-_75909543 0.584 ENSMUST00000123712.1
ENSMUST00000141475.1
ENSMUST00000144614.1
Eef1d


eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)


chr19_+_47579602 0.583 ENSMUST00000026043.5
Slk
STE20-like kinase
chr8_-_69902712 0.576 ENSMUST00000180068.1
Yjefn3
YjeF N-terminal domain containing 3
chr14_+_30825580 0.575 ENSMUST00000006701.5
Tmem110
transmembrane protein 110
chr1_+_92831614 0.573 ENSMUST00000045970.6
Gpc1
glypican 1
chr17_-_24696147 0.568 ENSMUST00000046839.8
Gfer
growth factor, erv1 (S. cerevisiae)-like (augmenter of liver regeneration)
chr18_+_84088077 0.566 ENSMUST00000060223.2
Zadh2
zinc binding alcohol dehydrogenase, domain containing 2
chr5_-_115119277 0.564 ENSMUST00000031524.7
Acads
acyl-Coenzyme A dehydrogenase, short chain
chr2_-_18392736 0.564 ENSMUST00000091418.5
ENSMUST00000166495.1
Dnajc1

DnaJ (Hsp40) homolog, subfamily C, member 1

chr1_+_60098254 0.563 ENSMUST00000124986.1
Carf
calcium response factor
chr7_+_120842824 0.563 ENSMUST00000047875.8
Eef2k
eukaryotic elongation factor-2 kinase
chr14_-_31830402 0.563 ENSMUST00000014640.7
Ankrd28
ankyrin repeat domain 28
chr12_+_11265867 0.562 ENSMUST00000020931.5
Smc6
structural maintenance of chromosomes 6
chr10_-_80399478 0.554 ENSMUST00000092295.3
ENSMUST00000105349.1
Mbd3

methyl-CpG binding domain protein 3

chr7_-_19604444 0.552 ENSMUST00000086041.5
Clasrp
CLK4-associating serine/arginine rich protein
chr9_-_71771535 0.550 ENSMUST00000122065.1
ENSMUST00000121322.1
ENSMUST00000072899.2
Cgnl1


cingulin-like 1


chr13_-_101768154 0.539 ENSMUST00000055518.6
Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr11_-_88718223 0.538 ENSMUST00000107909.1
Msi2
musashi RNA-binding protein 2
chr8_-_69902558 0.537 ENSMUST00000110167.3
Ndufa13
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
chr3_-_86920830 0.535 ENSMUST00000029719.8
Dclk2
doublecortin-like kinase 2
chr7_+_81213567 0.531 ENSMUST00000026672.7
Pde8a
phosphodiesterase 8A
chr5_+_63812447 0.523 ENSMUST00000081747.3
0610040J01Rik
RIKEN cDNA 0610040J01 gene
chr4_-_126968124 0.520 ENSMUST00000106108.2
Zmym4
zinc finger, MYM-type 4
chr2_+_156065738 0.509 ENSMUST00000137966.1
Spag4
sperm associated antigen 4
chrX_+_41401128 0.508 ENSMUST00000115103.2
Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chr7_-_3677509 0.506 ENSMUST00000038743.8
Tmc4
transmembrane channel-like gene family 4
chr17_+_35439155 0.505 ENSMUST00000071951.6
ENSMUST00000078205.7
ENSMUST00000116598.3
ENSMUST00000076256.7
H2-Q7



histocompatibility 2, Q region locus 7



chr11_-_107131922 0.503 ENSMUST00000057892.8
Bptf
bromodomain PHD finger transcription factor
chr6_+_124997062 0.496 ENSMUST00000159391.1
Pianp
PILR alpha associated neural protein
chr5_-_34187670 0.491 ENSMUST00000042701.6
ENSMUST00000119171.1
Mxd4

Max dimerization protein 4

chr17_+_24696234 0.491 ENSMUST00000019464.7
Noxo1
NADPH oxidase organizer 1
chr6_-_39725448 0.487 ENSMUST00000002487.8
Braf
Braf transforming gene
chr9_-_107635330 0.486 ENSMUST00000055704.6
Gnai2
guanine nucleotide binding protein (G protein), alpha inhibiting 2
chr7_+_120843551 0.478 ENSMUST00000106489.1
ENSMUST00000143279.1
Eef2k

eukaryotic elongation factor-2 kinase

chrX_-_7574120 0.473 ENSMUST00000045924.7
ENSMUST00000115742.2
ENSMUST00000150787.1
Ppp1r3f


protein phosphatase 1, regulatory (inhibitor) subunit 3F


chr11_-_72796028 0.472 ENSMUST00000156294.1
Cyb5d2
cytochrome b5 domain containing 2
chr11_-_88718165 0.467 ENSMUST00000107908.1
Msi2
musashi RNA-binding protein 2
chr12_-_108275409 0.465 ENSMUST00000136175.1
Ccdc85c
coiled-coil domain containing 85C
chr14_+_34673888 0.456 ENSMUST00000048263.7
Wapal
wings apart-like homolog (Drosophila)
chr6_+_41605482 0.455 ENSMUST00000114732.2
Ephb6
Eph receptor B6
chr8_+_41239718 0.445 ENSMUST00000045218.7
Pcm1
pericentriolar material 1
chr12_-_111485808 0.443 ENSMUST00000010673.5
Gm266
predicted gene 266
chr5_-_138170992 0.443 ENSMUST00000139983.1
Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
chr12_+_84038363 0.442 ENSMUST00000021652.3
Acot4
acyl-CoA thioesterase 4
chr17_+_28313513 0.437 ENSMUST00000114803.1
ENSMUST00000114801.1
ENSMUST00000114804.3
ENSMUST00000088007.4
Fance



Fanconi anemia, complementation group E



chr19_+_3851972 0.434 ENSMUST00000025760.6
Chka
choline kinase alpha
chr2_+_162931520 0.433 ENSMUST00000130411.1
Srsf6
serine/arginine-rich splicing factor 6
chr2_+_156065180 0.430 ENSMUST00000038860.5
Spag4
sperm associated antigen 4
chr13_-_24937585 0.428 ENSMUST00000037615.6
Aldh5a1
aldhehyde dehydrogenase family 5, subfamily A1
chr7_-_37772868 0.428 ENSMUST00000176205.1
Zfp536
zinc finger protein 536
chr7_+_25282179 0.427 ENSMUST00000163320.1
ENSMUST00000005578.6
Cic

capicua homolog (Drosophila)

chr3_+_36065979 0.419 ENSMUST00000011492.8
Acad9
acyl-Coenzyme A dehydrogenase family, member 9
chr6_-_24956106 0.416 ENSMUST00000127247.2
Tmem229a
transmembrane protein 229A
chr1_-_38129618 0.415 ENSMUST00000027251.6
Rev1
REV1 homolog (S. cerevisiae)
chr9_+_27030159 0.409 ENSMUST00000073127.7
ENSMUST00000086198.4
Ncapd3

non-SMC condensin II complex, subunit D3

chr6_-_142702259 0.408 ENSMUST00000073173.5
ENSMUST00000111771.1
ENSMUST00000087527.4
ENSMUST00000100827.2
Abcc9



ATP-binding cassette, sub-family C (CFTR/MRP), member 9



chr5_+_139150211 0.408 ENSMUST00000026975.6
Heatr2
HEAT repeat containing 2
chr1_+_92910758 0.406 ENSMUST00000027487.8
Rnpepl1
arginyl aminopeptidase (aminopeptidase B)-like 1
chr17_-_12318660 0.402 ENSMUST00000089058.5
Map3k4
mitogen-activated protein kinase kinase kinase 4
chr7_-_29232478 0.400 ENSMUST00000085818.4
Kcnk6
potassium inwardly-rectifying channel, subfamily K, member 6
chr2_-_168230575 0.400 ENSMUST00000109193.1
Dpm1
dolichol-phosphate (beta-D) mannosyltransferase 1
chr13_-_92131494 0.400 ENSMUST00000099326.3
ENSMUST00000146492.1
Rasgrf2

RAS protein-specific guanine nucleotide-releasing factor 2

chr8_-_90348343 0.391 ENSMUST00000109621.3
Tox3
TOX high mobility group box family member 3
chr13_-_43480973 0.389 ENSMUST00000144326.2
Ranbp9
RAN binding protein 9
chr2_+_26581050 0.388 ENSMUST00000166920.2
Egfl7
EGF-like domain 7
chr6_+_107529717 0.387 ENSMUST00000049285.8
Lrrn1
leucine rich repeat protein 1, neuronal
chr11_-_72795801 0.387 ENSMUST00000079681.5
Cyb5d2
cytochrome b5 domain containing 2
chr5_+_135168382 0.387 ENSMUST00000111187.3
ENSMUST00000111188.1
Bcl7b

B cell CLL/lymphoma 7B

chr11_+_78188737 0.378 ENSMUST00000108322.2
Rab34
RAB34, member of RAS oncogene family
chr16_+_65815508 0.374 ENSMUST00000168064.1
Vgll3
vestigial like 3 (Drosophila)
chr7_-_45333754 0.365 ENSMUST00000042194.8
Trpm4
transient receptor potential cation channel, subfamily M, member 4
chr8_+_92357787 0.363 ENSMUST00000034184.10
Irx5
Iroquois related homeobox 5 (Drosophila)
chrX_-_74023908 0.353 ENSMUST00000033769.8
ENSMUST00000114352.1
ENSMUST00000068286.5
ENSMUST00000114360.3
ENSMUST00000114354.3
Irak1




interleukin-1 receptor-associated kinase 1




chr5_-_138171248 0.352 ENSMUST00000153867.1
Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
chr5_-_138171216 0.352 ENSMUST00000147920.1
Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
chr4_+_86748526 0.349 ENSMUST00000082026.7
ENSMUST00000045512.8
Dennd4c

DENN/MADD domain containing 4C

chr5_-_72559599 0.348 ENSMUST00000074948.4
ENSMUST00000087216.5
Nfxl1

nuclear transcription factor, X-box binding-like 1

chr4_+_98395768 0.346 ENSMUST00000041284.3
Inadl
InaD-like (Drosophila)
chr9_+_106477269 0.345 ENSMUST00000047721.8
Rrp9
RRP9, small subunit (SSU) processome component, homolog (yeast)
chr5_+_100039990 0.339 ENSMUST00000169390.1
ENSMUST00000031268.6
Enoph1

enolase-phosphatase 1

chr4_-_128806045 0.336 ENSMUST00000106072.2
ENSMUST00000170934.1
Zfp362

zinc finger protein 362

chr5_+_135168283 0.335 ENSMUST00000031692.5
Bcl7b
B cell CLL/lymphoma 7B
chr19_+_3851797 0.332 ENSMUST00000072055.6
Chka
choline kinase alpha
chr4_-_132922547 0.332 ENSMUST00000030696.4
Fam76a
family with sequence similarity 76, member A
chr16_-_46496772 0.324 ENSMUST00000149901.1
ENSMUST00000096052.2
Pvrl3

poliovirus receptor-related 3

chr8_+_69902178 0.324 ENSMUST00000050373.5
Tssk6
testis-specific serine kinase 6
chr4_-_132922487 0.322 ENSMUST00000097856.3
Fam76a
family with sequence similarity 76, member A
chr3_+_87930256 0.322 ENSMUST00000055984.6
Isg20l2
interferon stimulated exonuclease gene 20-like 2
chr12_-_112674193 0.319 ENSMUST00000001780.3
Akt1
thymoma viral proto-oncogene 1
chr12_+_4592992 0.316 ENSMUST00000062580.7
Itsn2
intersectin 2
chr6_-_82774448 0.315 ENSMUST00000000642.4
Hk2
hexokinase 2
chr6_-_120038647 0.313 ENSMUST00000088646.5
ENSMUST00000177761.1
ENSMUST00000088644.6
ENSMUST00000060043.6
Wnk1



WNK lysine deficient protein kinase 1



chr8_-_46152159 0.312 ENSMUST00000110378.2
Snx25
sorting nexin 25
chr5_-_24601961 0.311 ENSMUST00000030791.7
Smarcd3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr1_+_91366412 0.311 ENSMUST00000086861.5
Fam132b
family with sequence similarity 132, member B
chr19_+_18670780 0.309 ENSMUST00000025632.9
2410127L17Rik
RIKEN cDNA 2410127L17 gene
chr11_+_74619594 0.302 ENSMUST00000100866.2
E130309D14Rik
RIKEN cDNA E130309D14 gene
chr19_-_8774431 0.300 ENSMUST00000010249.5
Tmem179b
transmembrane protein 179B
chr3_+_66985647 0.298 ENSMUST00000162362.1
ENSMUST00000065074.7
Rsrc1

arginine/serine-rich coiled-coil 1

chr5_+_28165690 0.296 ENSMUST00000036177.7
En2
engrailed 2
chr15_-_76538728 0.295 ENSMUST00000023219.7
Fbxl6
F-box and leucine-rich repeat protein 6
chr7_-_43489967 0.295 ENSMUST00000107974.1
Iglon5
IgLON family member 5
chrX_-_94123359 0.293 ENSMUST00000137853.1
ENSMUST00000088102.5
ENSMUST00000113927.1
Zfx


zinc finger protein X-linked


chr7_+_141327840 0.292 ENSMUST00000126510.1
ENSMUST00000145184.1
Tmem80

transmembrane protein 80

chr2_-_104494400 0.286 ENSMUST00000028600.7
Hipk3
homeodomain interacting protein kinase 3
chr3_+_107595031 0.283 ENSMUST00000014747.1
Alx3
aristaless-like homeobox 3
chr18_+_32163073 0.281 ENSMUST00000096575.3
Map3k2
mitogen-activated protein kinase kinase kinase 2
chr9_+_65141154 0.280 ENSMUST00000034961.4
Igdcc3
immunoglobulin superfamily, DCC subclass, member 3
chr8_-_84687839 0.277 ENSMUST00000001975.4
Nacc1
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
chr1_-_179517992 0.274 ENSMUST00000128302.1
ENSMUST00000111134.1
Smyd3

SET and MYND domain containing 3


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.7 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.5 1.6 GO:1904580 regulation of intracellular mRNA localization(GO:1904580)
0.5 3.2 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
0.5 1.4 GO:0060423 foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492)
0.4 1.2 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.3 1.7 GO:0006447 regulation of translational initiation by iron(GO:0006447) positive regulation of translational initiation by iron(GO:0045994)
0.3 0.3 GO:0003219 cardiac right ventricle formation(GO:0003219)
0.3 1.2 GO:0097168 condensed mesenchymal cell proliferation(GO:0072137) mesenchymal stem cell proliferation(GO:0097168)
0.3 1.2 GO:0001920 negative regulation of receptor recycling(GO:0001920) positive regulation of low-density lipoprotein particle receptor catabolic process(GO:0032805)
0.3 2.3 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.3 0.9 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
0.3 3.1 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.3 1.1 GO:0052151 positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation of apoptotic process by virus(GO:0060139) apoptotic process involved in embryonic digit morphogenesis(GO:1902263)
0.3 1.4 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.3 0.8 GO:0007521 muscle cell fate determination(GO:0007521) mammary placode formation(GO:0060596)
0.3 2.3 GO:0014807 regulation of somitogenesis(GO:0014807)
0.2 1.0 GO:0007354 zygotic determination of anterior/posterior axis, embryo(GO:0007354)
0.2 2.2 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.2 1.7 GO:0089700 protein kinase D signaling(GO:0089700)
0.2 1.5 GO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death(GO:1901300)
0.2 1.2 GO:0051775 response to redox state(GO:0051775)
0.2 0.6 GO:2001016 heparan sulfate proteoglycan catabolic process(GO:0030200) positive regulation of skeletal muscle cell differentiation(GO:2001016)
0.2 0.7 GO:2001045 response to indole-3-methanol(GO:0071680) cellular response to indole-3-methanol(GO:0071681) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.2 1.4 GO:0046459 short-chain fatty acid metabolic process(GO:0046459)
0.1 1.5 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.1 0.7 GO:2001168 regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168)
0.1 2.2 GO:0006817 phosphate ion transport(GO:0006817)
0.1 0.8 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646) choline metabolic process(GO:0019695)
0.1 1.5 GO:0010748 negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748)
0.1 1.1 GO:0042756 drinking behavior(GO:0042756)
0.1 0.9 GO:0018158 protein oxidation(GO:0018158)
0.1 1.1 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.1 1.0 GO:0006020 inositol metabolic process(GO:0006020)
0.1 0.5 GO:2000525 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.1 0.6 GO:0035864 response to potassium ion(GO:0035864) cellular response to potassium ion(GO:0035865)
0.1 0.4 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.1 0.4 GO:0045617 negative regulation of keratinocyte differentiation(GO:0045617)
0.1 0.3 GO:0002432 granuloma formation(GO:0002432)
0.1 0.5 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.1 1.5 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.1 0.3 GO:0023016 signal transduction by trans-phosphorylation(GO:0023016)
0.1 1.2 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.1 0.5 GO:0035590 purinergic nucleotide receptor signaling pathway(GO:0035590)
0.1 0.9 GO:0035095 behavioral response to nicotine(GO:0035095)
0.1 1.2 GO:0021891 olfactory bulb interneuron development(GO:0021891)
0.1 0.4 GO:1904179 positive regulation of adipose tissue development(GO:1904179)
0.1 0.2 GO:0090188 negative regulation of pancreatic juice secretion(GO:0090188)
0.1 1.7 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 0.3 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.1 0.6 GO:0060903 positive regulation of meiosis I(GO:0060903)
0.1 0.3 GO:0071544 diphosphoinositol polyphosphate catabolic process(GO:0071544)
0.1 0.2 GO:0030070 insulin processing(GO:0030070)
0.1 0.2 GO:0060854 patterning of lymph vessels(GO:0060854)
0.1 0.6 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.1 0.3 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.1 0.2 GO:0006059 hexitol metabolic process(GO:0006059)
0.1 0.3 GO:1902340 telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340)
0.1 0.4 GO:1905169 protein localization to phagocytic vesicle(GO:1905161) regulation of protein localization to phagocytic vesicle(GO:1905169) positive regulation of protein localization to phagocytic vesicle(GO:1905171)
0.1 0.2 GO:1903519 penetration of zona pellucida(GO:0007341) apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.1 0.4 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.1 1.0 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.1 1.2 GO:0036120 cellular response to platelet-derived growth factor stimulus(GO:0036120)
0.1 0.4 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.1 0.2 GO:1904049 negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
0.1 0.4 GO:0060075 regulation of resting membrane potential(GO:0060075)
0.1 0.3 GO:1901526 negative regulation of mitochondrial membrane permeability(GO:0035795) positive regulation of macromitophagy(GO:1901526) positive regulation of mitophagy in response to mitochondrial depolarization(GO:1904925)
0.1 0.3 GO:0043974 histone H3-K27 acetylation(GO:0043974) regulation of histone H3-K27 acetylation(GO:1901674)
0.1 0.2 GO:0045358 negative regulation of interferon-beta biosynthetic process(GO:0045358)
0.1 2.2 GO:0034629 cellular protein complex localization(GO:0034629)
0.1 0.4 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.1 3.6 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.1 0.5 GO:0010459 negative regulation of heart rate(GO:0010459)
0.1 2.3 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.1 0.4 GO:0019348 dolichol metabolic process(GO:0019348)
0.1 0.6 GO:0097421 liver regeneration(GO:0097421)
0.1 0.3 GO:0018242 protein O-linked glycosylation via serine(GO:0018242)
0.1 0.6 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.1 0.2 GO:0061739 protein lipidation involved in autophagosome assembly(GO:0061739)
0.1 0.2 GO:0060971 embryonic heart tube left/right pattern formation(GO:0060971)
0.1 0.9 GO:0043486 histone exchange(GO:0043486)
0.1 0.5 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.1 0.6 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.1 0.2 GO:2000642 negative regulation of early endosome to late endosome transport(GO:2000642)
0.1 1.1 GO:0042249 establishment of planar polarity of embryonic epithelium(GO:0042249)
0.1 0.4 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.0 0.2 GO:0042373 vitamin K metabolic process(GO:0042373)
0.0 0.9 GO:0035115 embryonic forelimb morphogenesis(GO:0035115)
0.0 0.1 GO:1990523 bone regeneration(GO:1990523)
0.0 0.3 GO:0036506 maintenance of unfolded protein(GO:0036506) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.0 0.3 GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
0.0 0.3 GO:0035092 sperm chromatin condensation(GO:0035092)
0.0 0.2 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.0 0.5 GO:2000465 regulation of glycogen (starch) synthase activity(GO:2000465)
0.0 3.8 GO:0050709 negative regulation of protein secretion(GO:0050709)
0.0 1.9 GO:0032835 glomerulus development(GO:0032835)
0.0 0.2 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.0 0.9 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.2 GO:0099515 actin filament-based transport(GO:0099515)
0.0 1.4 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 0.2 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.0 0.4 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.3 GO:0033129 positive regulation of histone phosphorylation(GO:0033129)
0.0 0.7 GO:0015909 long-chain fatty acid transport(GO:0015909)
0.0 0.5 GO:1901032 negative regulation of response to reactive oxygen species(GO:1901032) negative regulation of hydrogen peroxide-induced cell death(GO:1903206)
0.0 1.4 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.0 1.6 GO:0006414 translational elongation(GO:0006414)
0.0 0.3 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.0 0.7 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)
0.0 0.6 GO:0072337 modified amino acid transport(GO:0072337)
0.0 0.0 GO:0018307 enzyme active site formation(GO:0018307)
0.0 0.5 GO:0021860 pyramidal neuron development(GO:0021860)
0.0 0.2 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.0 0.3 GO:1990403 embryonic brain development(GO:1990403)
0.0 0.1 GO:0032886 regulation of microtubule-based process(GO:0032886)
0.0 0.5 GO:0022617 extracellular matrix disassembly(GO:0022617)
0.0 0.1 GO:0070309 lens fiber cell morphogenesis(GO:0070309)
0.0 0.1 GO:0072272 proximal/distal pattern formation involved in metanephric nephron development(GO:0072272)
0.0 0.1 GO:0046462 monoacylglycerol metabolic process(GO:0046462)
0.0 0.1 GO:0061188 regulation of chromatin silencing at rDNA(GO:0061187) negative regulation of chromatin silencing at rDNA(GO:0061188)
0.0 0.2 GO:0046959 habituation(GO:0046959)
0.0 0.3 GO:0071549 cellular response to dexamethasone stimulus(GO:0071549)
0.0 0.1 GO:0031998 regulation of fatty acid beta-oxidation(GO:0031998)
0.0 0.2 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.3 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 0.1 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.0 0.5 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.0 0.4 GO:0048599 oocyte development(GO:0048599)
0.0 0.1 GO:2000973 regulation of pro-B cell differentiation(GO:2000973)
0.0 0.6 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.6 GO:0048286 lung alveolus development(GO:0048286)
0.0 0.3 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.3 GO:0030934 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)
0.4 1.2 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.3 2.2 GO:0005827 polar microtubule(GO:0005827)
0.2 0.6 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.2 0.6 GO:0035061 interchromatin granule(GO:0035061)
0.1 0.4 GO:0000799 nuclear condensin complex(GO:0000799) germinal vesicle(GO:0042585)
0.1 0.4 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.1 2.4 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 0.4 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.1 1.1 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 0.5 GO:0043020 NADPH oxidase complex(GO:0043020)
0.1 0.6 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 0.9 GO:0046930 pore complex(GO:0046930)
0.1 0.6 GO:0005726 perichromatin fibrils(GO:0005726)
0.1 0.9 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 0.2 GO:0097543 ciliary inversin compartment(GO:0097543)
0.1 1.1 GO:0042555 MCM complex(GO:0042555)
0.1 0.6 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1 0.7 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.1 0.4 GO:0001940 male pronucleus(GO:0001940)
0.1 0.7 GO:0016600 flotillin complex(GO:0016600)
0.1 0.9 GO:0043083 synaptic cleft(GO:0043083)
0.1 1.4 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 0.2 GO:1990812 growth cone filopodium(GO:1990812)
0.0 0.3 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 2.3 GO:0016235 aggresome(GO:0016235)
0.0 0.3 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0 1.2 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 0.3 GO:0001740 Barr body(GO:0001740)
0.0 0.5 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.2 GO:1990761 growth cone lamellipodium(GO:1990761)
0.0 0.4 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.5 GO:0016589 NURF complex(GO:0016589)
0.0 0.9 GO:0000421 autophagosome membrane(GO:0000421)
0.0 1.4 GO:0031901 early endosome membrane(GO:0031901)
0.0 1.0 GO:0035869 ciliary transition zone(GO:0035869)
0.0 0.2 GO:0070578 RISC-loading complex(GO:0070578)
0.0 0.3 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.2 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.0 0.2 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.2 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 1.0 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.5 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.2 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.2 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.0 0.2 GO:0031045 dense core granule(GO:0031045)
0.0 1.5 GO:0005814 centriole(GO:0005814)
0.0 0.4 GO:0031985 Golgi cisterna(GO:0031985)
0.0 0.8 GO:0016459 myosin complex(GO:0016459)
0.0 4.0 GO:0000139 Golgi membrane(GO:0000139)
0.0 0.4 GO:0005811 lipid particle(GO:0005811)
0.0 0.6 GO:0005923 bicellular tight junction(GO:0005923)
0.0 5.8 GO:0031012 extracellular matrix(GO:0031012)
0.0 0.7 GO:0030027 lamellipodium(GO:0030027)
0.0 1.4 GO:0005884 actin filament(GO:0005884)
0.0 0.5 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 1.1 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 1.6 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.1 GO:0071564 npBAF complex(GO:0071564)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0034190 very-low-density lipoprotein particle binding(GO:0034189) apolipoprotein receptor binding(GO:0034190)
0.4 6.2 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.3 1.0 GO:0004686 elongation factor-2 kinase activity(GO:0004686)
0.3 1.7 GO:0070644 vitamin D response element binding(GO:0070644)
0.2 1.4 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.2 0.8 GO:0004104 choline kinase activity(GO:0004103) cholinesterase activity(GO:0004104) choline binding(GO:0033265)
0.2 0.6 GO:0070052 collagen V binding(GO:0070052)
0.2 0.6 GO:0036132 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
0.2 1.4 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.2 0.6 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.2 1.1 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.1 0.6 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.1 1.2 GO:0008420 CTD phosphatase activity(GO:0008420)
0.1 0.5 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.1 1.7 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.1 0.7 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.1 0.9 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 0.1 GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.1 0.9 GO:0043199 sulfate binding(GO:0043199)
0.1 0.5 GO:2001069 glycogen binding(GO:2001069)
0.1 1.6 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 1.5 GO:0043495 protein anchor(GO:0043495)
0.1 0.4 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.1 2.2 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 1.9 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.1 0.7 GO:0097322 7SK snRNA binding(GO:0097322)
0.1 1.0 GO:0048406 nerve growth factor binding(GO:0048406)
0.1 0.3 GO:0034511 U3 snoRNA binding(GO:0034511)
0.1 0.9 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 0.5 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.1 0.3 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.1 0.2 GO:0004335 galactokinase activity(GO:0004335)
0.1 0.2 GO:0031686 A1 adenosine receptor binding(GO:0031686)
0.1 2.7 GO:0050699 WW domain binding(GO:0050699)
0.1 0.5 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.1 1.5 GO:0017147 Wnt-protein binding(GO:0017147)
0.1 2.2 GO:0005112 Notch binding(GO:0005112)
0.1 0.3 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.1 0.3 GO:0045322 unmethylated CpG binding(GO:0045322)
0.1 0.9 GO:0046527 glucosyltransferase activity(GO:0046527)
0.1 0.4 GO:0034056 estrogen response element binding(GO:0034056)
0.1 4.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 1.0 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.1 1.2 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 1.3 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 2.0 GO:0005109 frizzled binding(GO:0005109)
0.0 0.2 GO:1904288 BAT3 complex binding(GO:1904288)
0.0 3.0 GO:0020037 heme binding(GO:0020037)
0.0 0.3 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.0 0.3 GO:0005536 glucose binding(GO:0005536)
0.0 0.3 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 0.9 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.2 GO:2001070 starch binding(GO:2001070)
0.0 0.7 GO:0017166 vinculin binding(GO:0017166)
0.0 0.2 GO:0003945 N-acetyllactosamine synthase activity(GO:0003945)
0.0 0.3 GO:0000298 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.0 1.5 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 0.2 GO:0043426 TFIIB-class transcription factor binding(GO:0001093) MRF binding(GO:0043426)
0.0 0.4 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.5 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.0 1.1 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 0.6 GO:0034713 type I transforming growth factor beta receptor binding(GO:0034713)
0.0 0.3 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.0 0.4 GO:1990226 histone methyltransferase binding(GO:1990226)
0.0 0.2 GO:0005042 netrin receptor activity(GO:0005042)
0.0 1.1 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 1.2 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.7 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.4 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 1.1 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.6 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.2 GO:0004185 serine-type carboxypeptidase activity(GO:0004185) serine-type exopeptidase activity(GO:0070008)
0.0 0.6 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 1.1 GO:0001221 transcription cofactor binding(GO:0001221)
0.0 0.3 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.5 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.1 GO:0008494 translation activator activity(GO:0008494)
0.0 1.2 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0 0.4 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 0.6 GO:0070888 E-box binding(GO:0070888)
0.0 1.8 GO:0046332 SMAD binding(GO:0046332)
0.0 0.2 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.3 GO:0000146 microfilament motor activity(GO:0000146)
0.0 0.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.3 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 1.4 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.2 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 1.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.1 GO:0039706 co-receptor binding(GO:0039706)
0.0 0.4 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.0 0.1 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 0.2 GO:0004659 prenyltransferase activity(GO:0004659)
0.0 0.1 GO:0004954 icosanoid receptor activity(GO:0004953) prostanoid receptor activity(GO:0004954) prostaglandin receptor activity(GO:0004955)
0.0 0.1 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 4.2 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 0.2 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 0.1 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.4 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.2 GO:0043274 phospholipase binding(GO:0043274)
0.0 0.5 GO:0008094 DNA-dependent ATPase activity(GO:0008094)
0.0 0.1 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.4 GO:0015459 potassium channel regulator activity(GO:0015459)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway
0.1 5.3 NABA_COLLAGENS Genes encoding collagen proteins
0.1 1.7 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.1 1.1 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 1.0 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 1.8 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.1 1.7 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.0 1.1 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.7 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.9 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 1.1 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.0 1.2 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 0.6 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 1.3 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.7 PID_IGF1_PATHWAY IGF1 pathway
0.0 1.1 PID_ATR_PATHWAY ATR signaling pathway
0.0 3.8 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.2 PID_TXA2PATHWAY Thromboxane A2 receptor signaling
0.0 1.3 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.5 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 0.5 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.3 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 0.4 PID_BARD1_PATHWAY BARD1 signaling events
0.0 0.4 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.3 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 2.5 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 0.8 ST_FAS_SIGNALING_PATHWAY Fas Signaling Pathway
0.0 0.3 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.7 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.3 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.6 PID_CASPASE_PATHWAY Caspase cascade in apoptosis

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.1 1.9 REACTOME_DESTABILIZATION_OF_MRNA_BY_BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.1 5.3 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 2.3 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 2.1 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.1 1.2 REACTOME_PECAM1_INTERACTIONS Genes involved in PECAM1 interactions
0.1 1.1 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.1 0.8 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.1 0.6 REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION Genes involved in Extracellular matrix organization
0.1 1.1 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.1 0.9 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.1 0.2 REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.0 0.5 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.4 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION_IN_TLR7_8_OR_9_SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 0.3 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.0 0.9 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.6 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 0.8 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.0 0.9 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 1.1 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.6 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.2 REACTOME_ADP_SIGNALLING_THROUGH_P2RY1 Genes involved in ADP signalling through P2Y purinoceptor 1
0.0 0.3 REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0 0.7 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 2.3 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.4 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.3 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.2 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.3 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.4 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
0.0 0.1 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.6 REACTOME_ELONGATION_ARREST_AND_RECOVERY Genes involved in Elongation arrest and recovery
0.0 0.2 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.4 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.2 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.1 REACTOME_ACYL_CHAIN_REMODELLING_OF_PS Genes involved in Acyl chain remodelling of PS
0.0 0.4 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.2 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.2 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 0.2 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.6 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import