Motif ID: En2

Z-value: 0.575


Transcription factors associated with En2:

Gene SymbolEntrez IDGene Name
En2 ENSMUSG00000039095.7 En2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
En2mm10_v2_chr5_+_28165690_28165717-0.561.2e-04Click!


Activity profile for motif En2.

activity profile for motif En2


Sorted Z-values histogram for motif En2

Sorted Z-values for motif En2



Network of associatons between targets according to the STRING database.



First level regulatory network of En2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_139543889 4.629 ENSMUST00000174792.1
ENSMUST00000031523.8
Uncx

UNC homeobox

chrX_-_60893430 3.555 ENSMUST00000135107.2
Sox3
SRY-box containing gene 3
chr5_-_53707532 3.395 ENSMUST00000031093.3
Cckar
cholecystokinin A receptor
chr6_+_8948608 2.973 ENSMUST00000160300.1
Nxph1
neurexophilin 1
chr13_-_114458720 2.516 ENSMUST00000022287.5
Fst
follistatin
chr6_+_4755327 2.428 ENSMUST00000176551.1
Peg10
paternally expressed 10
chr2_+_25372315 2.384 ENSMUST00000028329.6
ENSMUST00000114293.2
ENSMUST00000100323.2
Sapcd2


suppressor APC domain containing 2


chr5_+_33658123 2.226 ENSMUST00000074849.6
ENSMUST00000079534.4
Tacc3

transforming, acidic coiled-coil containing protein 3

chr12_+_109545390 2.142 ENSMUST00000146701.1
Meg3
maternally expressed 3
chr2_-_72986716 1.950 ENSMUST00000112062.1
Gm11084
predicted gene 11084
chr14_-_67715585 1.926 ENSMUST00000163100.1
ENSMUST00000132705.1
ENSMUST00000124045.1
Cdca2


cell division cycle associated 2


chr6_+_146888481 1.874 ENSMUST00000016631.7
ENSMUST00000111623.2
Ppfibp1

PTPRF interacting protein, binding protein 1 (liprin beta 1)

chr8_+_83955507 1.734 ENSMUST00000005607.8
Asf1b
ASF1 anti-silencing function 1 homolog B (S. cerevisiae)
chr3_-_27153861 1.721 ENSMUST00000108300.1
ENSMUST00000108298.2
Ect2

ect2 oncogene

chr18_-_80986578 1.690 ENSMUST00000057950.7
Sall3
sal-like 3 (Drosophila)
chr5_+_33658567 1.688 ENSMUST00000114426.3
Tacc3
transforming, acidic coiled-coil containing protein 3
chr3_-_27153844 1.616 ENSMUST00000176242.2
ENSMUST00000176780.1
Ect2

ect2 oncogene

chr4_+_62583568 1.589 ENSMUST00000098031.3
Rgs3
regulator of G-protein signaling 3
chr2_+_20737306 1.560 ENSMUST00000114606.1
ENSMUST00000114608.1
Etl4

enhancer trap locus 4

chr3_+_134236483 1.499 ENSMUST00000181904.1
ENSMUST00000053048.9
Cxxc4

CXXC finger 4

chr9_+_65890237 1.404 ENSMUST00000045802.6
2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr13_-_47106176 1.364 ENSMUST00000021807.6
ENSMUST00000135278.1
Dek

DEK oncogene (DNA binding)

chr8_-_90908415 1.338 ENSMUST00000098517.1
Gm6658
predicted gene 6658
chr3_-_116253467 1.330 ENSMUST00000090473.5
Gpr88
G-protein coupled receptor 88
chr5_+_33658550 1.319 ENSMUST00000152847.1
Tacc3
transforming, acidic coiled-coil containing protein 3
chr13_+_23544052 1.309 ENSMUST00000075558.2
Hist1h3f
histone cluster 1, H3f
chr2_-_57114970 1.282 ENSMUST00000028166.2
Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr6_-_50456085 1.245 ENSMUST00000146341.1
ENSMUST00000071728.4
Osbpl3

oxysterol binding protein-like 3

chr4_+_109978004 1.242 ENSMUST00000061187.3
Dmrta2
doublesex and mab-3 related transcription factor like family A2
chr8_-_45382198 1.228 ENSMUST00000093526.6
Fam149a
family with sequence similarity 149, member A
chr18_+_34625009 1.225 ENSMUST00000166044.1
Kif20a
kinesin family member 20A
chr13_+_21717626 1.207 ENSMUST00000091754.2
Hist1h3h
histone cluster 1, H3h
chr19_-_15924928 1.200 ENSMUST00000025542.3
Psat1
phosphoserine aminotransferase 1
chr17_+_34039437 1.192 ENSMUST00000131134.1
ENSMUST00000087497.4
ENSMUST00000114255.1
ENSMUST00000114252.1
Col11a2



collagen, type XI, alpha 2



chr5_-_77115145 1.151 ENSMUST00000081964.5
Hopx
HOP homeobox
chr3_+_159839729 1.149 ENSMUST00000068952.5
Wls
wntless homolog (Drosophila)
chr11_-_101095367 1.146 ENSMUST00000019447.8
Psmc3ip
proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting protein
chr19_-_15924560 1.125 ENSMUST00000162053.1
Psat1
phosphoserine aminotransferase 1
chr12_+_38780817 1.120 ENSMUST00000160856.1
Etv1
ets variant gene 1
chrX_+_134308084 1.071 ENSMUST00000081064.5
ENSMUST00000101251.1
ENSMUST00000129782.1
Cenpi


centromere protein I


chr12_+_38780284 1.058 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
Etv1


ets variant gene 1


chr18_+_34624621 1.057 ENSMUST00000167161.1
Kif20a
kinesin family member 20A
chr4_-_129558355 1.042 ENSMUST00000167288.1
ENSMUST00000134336.1
Lck

lymphocyte protein tyrosine kinase

chr14_+_67716095 1.035 ENSMUST00000078053.6
ENSMUST00000145542.1
ENSMUST00000125212.1
Kctd9


potassium channel tetramerisation domain containing 9


chr10_+_73821857 1.012 ENSMUST00000177128.1
ENSMUST00000064562.7
ENSMUST00000129404.2
ENSMUST00000105426.3
ENSMUST00000131321.2
ENSMUST00000126920.2
ENSMUST00000147189.2
ENSMUST00000105424.3
ENSMUST00000092420.6
ENSMUST00000105429.3
ENSMUST00000131724.2
ENSMUST00000152655.2
ENSMUST00000151116.2
ENSMUST00000155701.2
ENSMUST00000152819.2
ENSMUST00000125517.2
ENSMUST00000124046.1
ENSMUST00000149977.2
ENSMUST00000146682.1
ENSMUST00000177107.1
Pcdh15



















protocadherin 15



















chrM_+_7005 0.991 ENSMUST00000082405.1
mt-Co2
mitochondrially encoded cytochrome c oxidase II
chr13_+_5861489 0.983 ENSMUST00000000080.6
Klf6
Kruppel-like factor 6
chr10_+_26772477 0.955 ENSMUST00000039557.7
Arhgap18
Rho GTPase activating protein 18
chr1_+_110099295 0.949 ENSMUST00000134301.1
Cdh7
cadherin 7, type 2
chr1_+_131527901 0.948 ENSMUST00000068613.4
Fam72a
family with sequence similarity 72, member A
chr2_+_71389239 0.897 ENSMUST00000028408.2
Hat1
histone aminotransferase 1
chr4_-_14621805 0.861 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chr3_-_141982224 0.843 ENSMUST00000029948.8
Bmpr1b
bone morphogenetic protein receptor, type 1B
chr18_+_82914632 0.839 ENSMUST00000071233.6
Zfp516
zinc finger protein 516
chr19_+_25406661 0.774 ENSMUST00000146647.1
Kank1
KN motif and ankyrin repeat domains 1
chr15_-_38300693 0.748 ENSMUST00000074043.5
Klf10
Kruppel-like factor 10
chr4_-_14621669 0.738 ENSMUST00000143105.1
Slc26a7
solute carrier family 26, member 7
chrX_-_134111852 0.735 ENSMUST00000033610.6
Nox1
NADPH oxidase 1
chr3_-_79841729 0.735 ENSMUST00000168038.1
Tmem144
transmembrane protein 144
chr16_-_42340595 0.711 ENSMUST00000102817.4
Gap43
growth associated protein 43
chr7_+_27486910 0.695 ENSMUST00000008528.7
Sertad1
SERTA domain containing 1
chr7_+_101896340 0.645 ENSMUST00000035395.7
ENSMUST00000106973.1
ENSMUST00000144207.1
Anapc15


anaphase prompoting complex C subunit 15


chr9_-_66514567 0.643 ENSMUST00000056890.8
Fbxl22
F-box and leucine-rich repeat protein 22
chr12_-_56613270 0.622 ENSMUST00000072631.5
Nkx2-9
NK2 homeobox 9
chr9_+_45138437 0.610 ENSMUST00000060125.5
Scn4b
sodium channel, type IV, beta
chr4_+_130047840 0.601 ENSMUST00000044565.8
ENSMUST00000132251.1
Col16a1

collagen, type XVI, alpha 1

chr3_+_96268654 0.589 ENSMUST00000098843.2
Hist2h3b
histone cluster 2, H3b
chr4_-_14621494 0.588 ENSMUST00000149633.1
Slc26a7
solute carrier family 26, member 7
chr10_-_109010955 0.568 ENSMUST00000105276.1
ENSMUST00000064054.7
Syt1

synaptotagmin I

chr7_-_116198487 0.568 ENSMUST00000181981.1
Plekha7
pleckstrin homology domain containing, family A member 7
chr7_+_144838590 0.561 ENSMUST00000105898.1
Fgf3
fibroblast growth factor 3
chr15_+_80255184 0.559 ENSMUST00000109605.3
Atf4
activating transcription factor 4
chr4_+_150237694 0.540 ENSMUST00000141931.1
Eno1
enolase 1, alpha non-neuron
chr5_+_81021583 0.537 ENSMUST00000121707.1
Lphn3
latrophilin 3
chr1_-_78968079 0.525 ENSMUST00000049117.5
Gm5830
predicted pseudogene 5830
chr9_-_107635330 0.521 ENSMUST00000055704.6
Gnai2
guanine nucleotide binding protein (G protein), alpha inhibiting 2
chr18_-_88927447 0.492 ENSMUST00000147313.1
Socs6
suppressor of cytokine signaling 6
chr2_+_14873656 0.460 ENSMUST00000114718.1
ENSMUST00000114719.1
Cacnb2

calcium channel, voltage-dependent, beta 2 subunit

chr5_+_135106881 0.457 ENSMUST00000005507.3
Mlxipl
MLX interacting protein-like
chrX_+_102119447 0.448 ENSMUST00000113627.3
Pin4
protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)
chrX_-_57338598 0.433 ENSMUST00000033468.4
ENSMUST00000114736.1
Arhgef6

Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6

chr14_+_58070547 0.426 ENSMUST00000165526.1
Fgf9
fibroblast growth factor 9
chr9_-_109082372 0.414 ENSMUST00000167504.1
Tma7
translational machinery associated 7 homolog (S. cerevisiae)
chrX_-_136741155 0.409 ENSMUST00000166930.1
ENSMUST00000113095.1
ENSMUST00000155207.1
ENSMUST00000080411.6
ENSMUST00000169418.1
Morf4l2




mortality factor 4 like 2




chr18_+_56432116 0.408 ENSMUST00000070166.5
Gramd3
GRAM domain containing 3
chr12_-_91779129 0.401 ENSMUST00000170077.1
Ston2
stonin 2
chr5_+_138187485 0.400 ENSMUST00000110934.2
Cnpy4
canopy 4 homolog (zebrafish)
chr13_-_113663670 0.397 ENSMUST00000054650.4
Hspb3
heat shock protein 3
chr13_+_23574381 0.372 ENSMUST00000090776.4
Hist1h2ad
histone cluster 1, H2ad
chr2_+_9882622 0.371 ENSMUST00000114919.1
4930412O13Rik
RIKEN cDNA 4930412O13 gene
chr14_+_67716262 0.359 ENSMUST00000150768.1
Kctd9
potassium channel tetramerisation domain containing 9
chr8_-_84237042 0.357 ENSMUST00000039480.5
Zswim4
zinc finger SWIM-type containing 4
chr7_+_103550368 0.352 ENSMUST00000106888.1
Olfr613
olfactory receptor 613
chr18_-_61707583 0.350 ENSMUST00000025472.1
Pcyox1l
prenylcysteine oxidase 1 like
chr1_-_75046639 0.342 ENSMUST00000152855.1
Nhej1
nonhomologous end-joining factor 1
chr12_+_108605757 0.315 ENSMUST00000109854.2
Evl
Ena-vasodilator stimulated phosphoprotein
chr6_-_85451248 0.314 ENSMUST00000113770.1
ENSMUST00000032080.2
Pradc1

protease-associated domain containing 1

chr7_-_30559828 0.307 ENSMUST00000108164.1
Lin37
lin-37 homolog (C. elegans)
chr3_+_96629919 0.304 ENSMUST00000048915.6
Rbm8a
RNA binding motif protein 8a
chr3_-_55055038 0.303 ENSMUST00000029368.2
Ccna1
cyclin A1
chrX_-_157415286 0.299 ENSMUST00000079945.4
ENSMUST00000138396.1
Phex

phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)

chrX_+_75514299 0.294 ENSMUST00000114070.3
ENSMUST00000033540.5
Vbp1

von Hippel-Lindau binding protein 1

chr17_+_35424842 0.293 ENSMUST00000174699.1
H2-Q6
histocompatibility 2, Q region locus 6
chr5_-_138187177 0.291 ENSMUST00000110937.1
ENSMUST00000139276.1
ENSMUST00000048698.7
ENSMUST00000123415.1
Taf6



TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor



chr17_-_24886304 0.287 ENSMUST00000044252.5
Nubp2
nucleotide binding protein 2
chr6_-_71632897 0.281 ENSMUST00000065509.4
Kdm3a
lysine (K)-specific demethylase 3A
chr8_-_84662841 0.269 ENSMUST00000060427.4
Ier2
immediate early response 2
chrM_+_3906 0.267 ENSMUST00000082396.1
mt-Nd2
mitochondrially encoded NADH dehydrogenase 2
chr11_-_31671863 0.266 ENSMUST00000058060.7
Bod1
biorientation of chromosomes in cell division 1
chr7_-_45830776 0.264 ENSMUST00000107723.2
ENSMUST00000131384.1
Grwd1

glutamate-rich WD repeat containing 1

chr12_+_72441852 0.263 ENSMUST00000162159.1
Lrrc9
leucine rich repeat containing 9
chrM_+_7759 0.255 ENSMUST00000082407.1
ENSMUST00000082408.1
mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr19_+_6046576 0.253 ENSMUST00000138532.1
ENSMUST00000129081.1
ENSMUST00000156550.1
Syvn1


synovial apoptosis inhibitor 1, synoviolin


chr7_-_30559600 0.247 ENSMUST00000043975.4
ENSMUST00000156241.1
Lin37

lin-37 homolog (C. elegans)

chr12_+_72441933 0.246 ENSMUST00000161284.1
Lrrc9
leucine rich repeat containing 9
chr18_+_84851338 0.241 ENSMUST00000160180.1
Cyb5
cytochrome b-5
chr16_+_52031549 0.241 ENSMUST00000114471.1
Cblb
Casitas B-lineage lymphoma b
chr5_+_88583527 0.234 ENSMUST00000031229.6
Rufy3
RUN and FYVE domain containing 3
chr3_+_19188099 0.233 ENSMUST00000130645.1
Mtfr1
mitochondrial fission regulator 1
chr1_+_66468364 0.226 ENSMUST00000061620.9
Unc80
unc-80 homolog (C. elegans)
chr3_+_76075583 0.218 ENSMUST00000160261.1
Fstl5
follistatin-like 5
chr14_-_55560340 0.217 ENSMUST00000066106.3
A730061H03Rik
RIKEN cDNA A730061H03 gene
chr17_+_45734506 0.216 ENSMUST00000180558.1
F630040K05Rik
RIKEN cDNA F630040K05 gene
chr3_-_107333289 0.211 ENSMUST00000061772.9
Rbm15
RNA binding motif protein 15
chr12_-_85280361 0.209 ENSMUST00000065913.7
ENSMUST00000008966.6
Acyp1

acylphosphatase 1, erythrocyte (common) type

chr3_+_88207308 0.208 ENSMUST00000180582.1
Gm3764
predicted gene 3764
chr6_-_71632651 0.201 ENSMUST00000167220.1
Kdm3a
lysine (K)-specific demethylase 3A
chr6_-_146502141 0.190 ENSMUST00000079573.6
ENSMUST00000139732.1
Itpr2

inositol 1,4,5-triphosphate receptor 2

chrM_+_9452 0.189 ENSMUST00000082411.1
mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chr14_+_32321987 0.189 ENSMUST00000022480.7
Ogdhl
oxoglutarate dehydrogenase-like
chr13_-_23574196 0.184 ENSMUST00000105106.1
Hist1h2bf
histone cluster 1, H2bf
chr9_+_113930934 0.177 ENSMUST00000084885.5
ENSMUST00000009885.7
Ubp1

upstream binding protein 1

chr19_+_25672408 0.168 ENSMUST00000053068.5
Dmrt2
doublesex and mab-3 related transcription factor 2
chr7_+_88430257 0.148 ENSMUST00000107256.2
Rab38
RAB38, member of RAS oncogene family
chr9_-_71163224 0.142 ENSMUST00000074465.2
Aqp9
aquaporin 9
chr13_-_92030897 0.125 ENSMUST00000149630.1
Rasgrf2
RAS protein-specific guanine nucleotide-releasing factor 2
chr14_+_79515618 0.116 ENSMUST00000110835.1
Elf1
E74-like factor 1
chr13_-_23710714 0.112 ENSMUST00000091707.6
ENSMUST00000006787.7
ENSMUST00000091706.6
Hfe


hemochromatosis


chr14_+_53324632 0.108 ENSMUST00000178100.1
Trav7n-6
T cell receptor alpha variable 7N-6
chrM_+_2743 0.106 ENSMUST00000082392.1
mt-Nd1
mitochondrially encoded NADH dehydrogenase 1
chr17_-_12960306 0.104 ENSMUST00000159697.1
Acat2
acetyl-Coenzyme A acetyltransferase 2
chr3_-_146682410 0.098 ENSMUST00000124931.1
ENSMUST00000147113.1
Samd13

sterile alpha motif domain containing 13

chr2_+_152754156 0.098 ENSMUST00000010020.5
Cox4i2
cytochrome c oxidase subunit IV isoform 2
chr5_-_137531952 0.094 ENSMUST00000140139.1
Gnb2
guanine nucleotide binding protein (G protein), beta 2
chr18_+_42511496 0.093 ENSMUST00000025375.7
Tcerg1
transcription elongation regulator 1 (CA150)
chr19_+_3851797 0.092 ENSMUST00000072055.6
Chka
choline kinase alpha
chr8_+_106150359 0.091 ENSMUST00000034377.6
Pla2g15
phospholipase A2, group XV
chr19_-_6942406 0.091 ENSMUST00000099782.3
Gpr137
G protein-coupled receptor 137
chr3_+_108653931 0.065 ENSMUST00000029483.8
ENSMUST00000124384.1
Clcc1

chloride channel CLIC-like 1

chr11_-_102946688 0.064 ENSMUST00000057849.5
C1ql1
complement component 1, q subcomponent-like 1
chr7_+_5015466 0.061 ENSMUST00000086349.3
Zfp524
zinc finger protein 524
chrX_+_152001845 0.060 ENSMUST00000026289.3
ENSMUST00000112617.3
Hsd17b10

hydroxysteroid (17-beta) dehydrogenase 10

chr15_+_100334929 0.052 ENSMUST00000075420.4
Mettl7a3
methyltransferase like 7A3
chr16_+_45093611 0.047 ENSMUST00000099498.2
Ccdc80
coiled-coil domain containing 80
chrX_-_37110257 0.042 ENSMUST00000076265.6
Upf3b
UPF3 regulator of nonsense transcripts homolog B (yeast)
chrX_+_56454871 0.040 ENSMUST00000039374.2
ENSMUST00000101553.2
Ddx26b

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B

chrX_+_20687954 0.039 ENSMUST00000115364.1
Cdk16
cyclin-dependent kinase 16
chr11_-_31671727 0.036 ENSMUST00000109415.1
Bod1
biorientation of chromosomes in cell division 1
chr9_+_107563246 0.033 ENSMUST00000010198.3
Tusc2
tumor suppressor candidate 2
chr19_+_6942501 0.031 ENSMUST00000113423.3
Bad
BCL2-associated agonist of cell death
chr4_+_150853919 0.029 ENSMUST00000073600.2
Errfi1
ERBB receptor feedback inhibitor 1
chr19_+_3851972 0.028 ENSMUST00000025760.6
Chka
choline kinase alpha
chr2_-_27475622 0.025 ENSMUST00000138693.1
ENSMUST00000113941.2
ENSMUST00000077737.6
Brd3


bromodomain containing 3


chr7_+_25681158 0.025 ENSMUST00000108403.3
B9d2
B9 protein domain 2
chr11_+_69059750 0.014 ENSMUST00000051888.2
2310047M10Rik
RIKEN cDNA 2310047M10 gene
chr4_+_21848039 0.012 ENSMUST00000098238.2
ENSMUST00000108229.1
Sfrs18

serine/arginine-rich splicing factor 18

chr6_+_85451488 0.003 ENSMUST00000032078.6
Cct7
chaperonin containing Tcp1, subunit 7 (eta)
chr8_+_94037198 0.003 ENSMUST00000109556.2
ENSMUST00000093301.2
ENSMUST00000060632.7
Ogfod1


2-oxoglutarate and iron-dependent oxygenase domain containing 1



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.4 GO:0090274 positive regulation of somatostatin secretion(GO:0090274)
0.6 4.6 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.5 2.3 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.4 1.2 GO:0060023 soft palate development(GO:0060023)
0.4 1.1 GO:0061357 Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) positive regulation of Wnt protein secretion(GO:0061357)
0.3 1.4 GO:0061743 motor learning(GO:0061743)
0.3 1.3 GO:0051866 general adaptation syndrome(GO:0051866)
0.3 2.2 GO:0019532 oxalate transport(GO:0019532)
0.3 5.2 GO:0030953 astral microtubule organization(GO:0030953)
0.3 2.5 GO:0051798 positive regulation of hair follicle development(GO:0051798)
0.3 1.4 GO:2001032 regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.3 0.8 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.2 0.7 GO:0045113 regulation of integrin biosynthetic process(GO:0045113)
0.2 0.8 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.2 2.2 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.2 1.2 GO:0043415 positive regulation of skeletal muscle tissue regeneration(GO:0043415)
0.2 4.0 GO:0007530 sex determination(GO:0007530)
0.2 3.3 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.2 0.5 GO:0007290 spermatid nucleus elongation(GO:0007290)
0.2 0.5 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.1 4.4 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.1 0.6 GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)
0.1 0.9 GO:0031547 brain-derived neurotrophic factor receptor signaling pathway(GO:0031547)
0.1 1.0 GO:0046645 positive regulation of gamma-delta T cell differentiation(GO:0045588) positive regulation of gamma-delta T cell activation(GO:0046645) positive regulation of uterine smooth muscle contraction(GO:0070474)
0.1 2.3 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.1 1.0 GO:0050957 equilibrioception(GO:0050957)
0.1 1.7 GO:0021891 olfactory bulb interneuron development(GO:0021891)
0.1 0.7 GO:0016198 axon choice point recognition(GO:0016198)
0.1 0.3 GO:0030327 prenylated protein catabolic process(GO:0030327)
0.1 0.5 GO:0090324 negative regulation of oxidative phosphorylation(GO:0090324)
0.1 0.6 GO:0045218 zonula adherens maintenance(GO:0045218)
0.1 0.2 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.1 0.3 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.1 1.2 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.1 0.6 GO:0005513 detection of calcium ion(GO:0005513)
0.1 0.3 GO:0007021 tubulin complex assembly(GO:0007021)
0.1 0.7 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.1 0.2 GO:0061055 myotome development(GO:0061055)
0.1 0.1 GO:0002725 negative regulation of T cell cytokine production(GO:0002725)
0.0 1.3 GO:0008340 determination of adult lifespan(GO:0008340)
0.0 0.6 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.6 GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization(GO:0060307)
0.0 0.5 GO:0001973 adenosine receptor signaling pathway(GO:0001973)
0.0 0.2 GO:0030916 otic vesicle formation(GO:0030916)
0.0 0.1 GO:0060155 platelet dense granule organization(GO:0060155)
0.0 0.1 GO:0030300 regulation of intestinal cholesterol absorption(GO:0030300)
0.0 1.1 GO:0034508 centromere complex assembly(GO:0034508)
0.0 1.1 GO:0007131 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.0 0.7 GO:0045672 positive regulation of osteoclast differentiation(GO:0045672)
0.0 1.8 GO:0035307 positive regulation of protein dephosphorylation(GO:0035307)
0.0 0.2 GO:0071361 cellular response to ethanol(GO:0071361)
0.0 0.2 GO:0046337 phosphatidylethanolamine metabolic process(GO:0046337)
0.0 0.6 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894)
0.0 0.8 GO:0009409 response to cold(GO:0009409)
0.0 1.5 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.0 1.8 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.1 GO:0015791 polyol transport(GO:0015791) bile acid secretion(GO:0032782)
0.0 0.0 GO:0075136 response to defenses of other organism involved in symbiotic interaction(GO:0052173) response to host defenses(GO:0052200) response to host(GO:0075136)
0.0 0.3 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.2 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 0.1 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.1 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.0 GO:1902220 positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902220)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 3.3 GO:0097149 centralspindlin complex(GO:0097149)
0.2 0.7 GO:0071438 invadopodium membrane(GO:0071438)
0.1 0.6 GO:1990590 ATF1-ATF4 transcription factor complex(GO:1990590)
0.1 1.1 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 0.5 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 0.3 GO:0032807 DNA ligase IV complex(GO:0032807)
0.1 1.8 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 0.6 GO:0005915 zonula adherens(GO:0005915)
0.0 0.1 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.5 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 1.2 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 1.0 GO:0000242 pericentriolar material(GO:0000242)
0.0 0.6 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.2 GO:0071437 invadopodium(GO:0071437)
0.0 0.4 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 2.3 GO:0005871 kinesin complex(GO:0005871)
0.0 1.3 GO:0000786 nucleosome(GO:0000786)
0.0 0.7 GO:0031527 filopodium membrane(GO:0031527)
0.0 1.1 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 4.0 GO:0043195 terminal bouton(GO:0043195)
0.0 0.3 GO:0016272 prefoldin complex(GO:0016272)
0.0 1.0 GO:0032420 stereocilium(GO:0032420)
0.0 0.1 GO:1990357 terminal web(GO:1990357)
0.0 0.3 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 0.2 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.3 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 1.3 GO:0005581 collagen trimer(GO:0005581)
0.0 0.3 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.5 GO:0001772 immunological synapse(GO:0001772)
0.0 0.3 GO:0005797 Golgi medial cisterna(GO:0005797)
0.0 0.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.3 GO:0005680 anaphase-promoting complex(GO:0005680)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.2 2.5 GO:0048185 activin binding(GO:0048185)
0.2 1.0 GO:0042610 CD8 receptor binding(GO:0042610)
0.2 2.2 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.1 0.6 GO:0030348 syntaxin-3 binding(GO:0030348)
0.1 0.8 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 2.3 GO:0008483 transaminase activity(GO:0008483)
0.1 1.1 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.1 0.4 GO:0003681 bent DNA binding(GO:0003681)
0.1 0.7 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.1 3.6 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 0.5 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.1 0.6 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.1 0.3 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.1 1.1 GO:0050692 DBD domain binding(GO:0050692)
0.1 3.1 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 0.2 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.1 0.5 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 0.4 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 0.2 GO:0003998 acylphosphatase activity(GO:0003998)
0.0 0.9 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.0 0.1 GO:0035651 AP-1 adaptor complex binding(GO:0035650) AP-3 adaptor complex binding(GO:0035651)
0.0 0.6 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.6 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 2.5 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.0 0.3 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670)
0.0 1.1 GO:0097602 cullin family protein binding(GO:0097602)
0.0 1.3 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.1 GO:0015254 glycerol channel activity(GO:0015254)
0.0 0.7 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 1.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.7 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.1 GO:0004104 choline kinase activity(GO:0004103) cholinesterase activity(GO:0004104) choline binding(GO:0033265)
0.0 0.2 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 2.3 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.5 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 0.5 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.3 GO:0005522 profilin binding(GO:0005522)
0.0 1.2 GO:0015485 cholesterol binding(GO:0015485)
0.0 1.3 GO:0003774 motor activity(GO:0003774)
0.0 0.8 GO:0008013 beta-catenin binding(GO:0008013)
0.0 2.4 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 0.3 GO:0046977 TAP binding(GO:0046977)
0.0 0.3 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.7 GO:0015144 carbohydrate transmembrane transporter activity(GO:0015144) carbohydrate transporter activity(GO:1901476)
0.0 0.1 GO:0016453 acetyl-CoA C-acetyltransferase activity(GO:0003985) C-acetyltransferase activity(GO:0016453)
0.0 0.3 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0 0.1 GO:0039706 co-receptor binding(GO:0039706)
0.0 5.4 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987)
0.0 0.3 GO:0043566 structure-specific DNA binding(GO:0043566)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.5 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 5.2 PID_PLK1_PATHWAY PLK1 signaling events
0.1 3.4 PID_BMP_PATHWAY BMP receptor signaling
0.1 2.6 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 2.2 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.5 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 1.5 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 1.2 NABA_COLLAGENS Genes encoding collagen proteins
0.0 3.0 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.3 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.7 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 0.6 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.0 0.9 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.3 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.4 PID_FGF_PATHWAY FGF signaling pathway
0.0 0.4 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 0.3 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.2 PID_CD40_PATHWAY CD40/CD40L signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 2.3 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 2.3 REACTOME_KINESINS Genes involved in Kinesins
0.1 0.6 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 3.1 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 0.6 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 0.7 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 1.1 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.5 REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.0 0.2 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 2.5 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.8 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 2.0 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 0.5 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.3 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.5 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.0 1.2 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 1.3 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.1 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.5 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.5 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.2 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers