Motif ID: Hoxa7_Hoxc8

Z-value: 0.514

Transcription factors associated with Hoxa7_Hoxc8:

Gene SymbolEntrez IDGene Name
Hoxa7 ENSMUSG00000038236.6 Hoxa7
Hoxc8 ENSMUSG00000001657.6 Hoxc8






Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa7_Hoxc8

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_+_80000292 5.353 ENSMUST00000088735.3
Olfm4
olfactomedin 4
chr5_-_62766153 4.148 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr6_-_137169710 3.657 ENSMUST00000117919.1
Rerg
RAS-like, estrogen-regulated, growth-inhibitor
chrX_-_143933089 3.035 ENSMUST00000087313.3
Dcx
doublecortin
chr14_-_100149764 2.172 ENSMUST00000097079.4
Klf12
Kruppel-like factor 12
chr7_-_46667375 2.161 ENSMUST00000107669.2
Tph1
tryptophan hydroxylase 1
chr3_+_5218516 1.930 ENSMUST00000175866.1
Zfhx4
zinc finger homeodomain 4
chrX_-_143933204 1.533 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
Dcx


doublecortin


chr17_-_45659312 1.480 ENSMUST00000120717.1
Capn11
calpain 11
chr9_-_55919605 1.350 ENSMUST00000037408.8
Scaper
S phase cyclin A-associated protein in the ER
chr6_-_118479237 1.307 ENSMUST00000161170.1
Zfp9
zinc finger protein 9
chr2_+_69897255 1.216 ENSMUST00000131553.1
Ubr3
ubiquitin protein ligase E3 component n-recognin 3
chr2_+_116067213 1.199 ENSMUST00000152412.1
G630016G05Rik
RIKEN cDNA G630016G05 gene
chr17_+_88440711 1.128 ENSMUST00000112238.2
ENSMUST00000155640.1
Foxn2

forkhead box N2

chr1_-_134955847 1.037 ENSMUST00000168381.1
Ppp1r12b
protein phosphatase 1, regulatory (inhibitor) subunit 12B
chr10_-_117148474 0.970 ENSMUST00000020381.3
Frs2
fibroblast growth factor receptor substrate 2
chr15_-_8710409 0.954 ENSMUST00000157065.1
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr2_-_116067391 0.900 ENSMUST00000140185.1
2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr9_-_103228420 0.874 ENSMUST00000126359.1
Trf
transferrin
chr3_+_5218589 0.859 ENSMUST00000177488.1
Zfhx4
zinc finger homeodomain 4
chr18_+_37518341 0.851 ENSMUST00000097609.1
Pcdhb22
protocadherin beta 22
chr1_+_72284367 0.851 ENSMUST00000027380.5
ENSMUST00000141783.1
Tmem169

transmembrane protein 169

chr9_-_90255927 0.846 ENSMUST00000144646.1
Tbc1d2b
TBC1 domain family, member 2B
chr6_+_30541582 0.817 ENSMUST00000096066.4
Cpa2
carboxypeptidase A2, pancreatic
chr3_+_5218546 0.814 ENSMUST00000026284.6
Zfhx4
zinc finger homeodomain 4
chrM_+_9870 0.807 ENSMUST00000084013.1
mt-Nd4l
mitochondrially encoded NADH dehydrogenase 4L
chr12_-_87775755 0.792 ENSMUST00000164517.2
Gm21319
predicted gene, 21319
chr14_-_36919314 0.786 ENSMUST00000182797.1
Ccser2
coiled-coil serine rich 2
chr13_+_42681513 0.780 ENSMUST00000149235.1
Phactr1
phosphatase and actin regulator 1
chr2_+_69897220 0.779 ENSMUST00000055758.9
ENSMUST00000112251.2
Ubr3

ubiquitin protein ligase E3 component n-recognin 3

chr2_-_177267036 0.777 ENSMUST00000108963.1
Gm14409
predicted gene 14409
chr7_+_51621830 0.773 ENSMUST00000032710.5
Slc17a6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr14_-_108914237 0.771 ENSMUST00000100322.2
Slitrk1
SLIT and NTRK-like family, member 1
chr4_+_108719649 0.742 ENSMUST00000178992.1
3110021N24Rik
RIKEN cDNA 3110021N24 gene
chr1_-_134955908 0.734 ENSMUST00000045665.6
ENSMUST00000086444.4
ENSMUST00000112163.1
Ppp1r12b


protein phosphatase 1, regulatory (inhibitor) subunit 12B


chr11_+_29373618 0.726 ENSMUST00000040182.6
ENSMUST00000109477.1
Ccdc88a

coiled coil domain containing 88A

chr17_-_36032682 0.681 ENSMUST00000102678.4
H2-T23
histocompatibility 2, T region locus 23
chr5_+_66968559 0.681 ENSMUST00000127184.1
Limch1
LIM and calponin homology domains 1
chr13_+_83732438 0.645 ENSMUST00000182701.1
C130071C03Rik
RIKEN cDNA C130071C03 gene
chr9_+_113812547 0.613 ENSMUST00000166734.2
ENSMUST00000111838.2
ENSMUST00000163895.2
Clasp2


CLIP associating protein 2


chr2_+_109917639 0.577 ENSMUST00000046548.7
ENSMUST00000111037.2
Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr2_-_79456750 0.563 ENSMUST00000041099.4
Neurod1
neurogenic differentiation 1
chr5_+_29195983 0.563 ENSMUST00000160888.1
ENSMUST00000159272.1
ENSMUST00000001247.5
ENSMUST00000161398.1
ENSMUST00000160246.1
Rnf32




ring finger protein 32




chr15_-_8710734 0.546 ENSMUST00000005493.7
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr17_-_29007925 0.472 ENSMUST00000009138.5
ENSMUST00000119274.1
Stk38

serine/threonine kinase 38

chr2_-_45117349 0.468 ENSMUST00000176438.2
Zeb2
zinc finger E-box binding homeobox 2
chr7_+_126950687 0.465 ENSMUST00000106333.1
Sez6l2
seizure related 6 homolog like 2
chr18_+_32067729 0.448 ENSMUST00000025243.3
Iws1
IWS1 homolog (S. cerevisiae)
chr2_+_125136692 0.423 ENSMUST00000099452.2
Ctxn2
cortexin 2
chr5_+_66968416 0.405 ENSMUST00000038188.7
Limch1
LIM and calponin homology domains 1
chr3_+_55461758 0.401 ENSMUST00000070418.4
Dclk1
doublecortin-like kinase 1
chr9_+_110052016 0.398 ENSMUST00000164930.1
ENSMUST00000163979.1
Map4

microtubule-associated protein 4

chr8_+_45885479 0.375 ENSMUST00000034053.5
Pdlim3
PDZ and LIM domain 3
chr6_+_145934113 0.354 ENSMUST00000032383.7
Sspn
sarcospan
chr7_+_103550368 0.351 ENSMUST00000106888.1
Olfr613
olfactory receptor 613
chr3_-_66296807 0.348 ENSMUST00000029419.7
Veph1
ventricular zone expressed PH domain-containing 1
chr1_-_24612700 0.324 ENSMUST00000088336.1
Gm10222
predicted gene 10222
chr1_+_82316452 0.310 ENSMUST00000027322.7
Rhbdd1
rhomboid domain containing 1
chr18_+_23753708 0.308 ENSMUST00000115830.1
Mapre2
microtubule-associated protein, RP/EB family, member 2
chr10_-_86011833 0.300 ENSMUST00000105304.1
ENSMUST00000061699.5
Bpifc

BPI fold containing family C

chr10_+_116018213 0.297 ENSMUST00000063470.4
Ptprr
protein tyrosine phosphatase, receptor type, R
chr13_+_43785107 0.293 ENSMUST00000015540.2
Cd83
CD83 antigen
chr4_-_82850721 0.291 ENSMUST00000139401.1
Zdhhc21
zinc finger, DHHC domain containing 21
chr5_-_62765618 0.276 ENSMUST00000159470.1
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr4_+_100478806 0.268 ENSMUST00000133493.2
ENSMUST00000092730.3
ENSMUST00000106979.3
Ube2u


ubiquitin-conjugating enzyme E2U (putative)


chr12_+_71170589 0.264 ENSMUST00000129376.1
2700049A03Rik
RIKEN cDNA 2700049A03 gene
chr2_+_23069210 0.261 ENSMUST00000155602.1
Acbd5
acyl-Coenzyme A binding domain containing 5
chr19_-_32196393 0.254 ENSMUST00000151822.1
Sgms1
sphingomyelin synthase 1
chr10_+_75037066 0.251 ENSMUST00000147802.1
ENSMUST00000020391.5
Rab36

RAB36, member RAS oncogene family

chr15_-_75905349 0.241 ENSMUST00000127550.1
Eef1d
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
chrX_+_16619698 0.238 ENSMUST00000026013.5
Maoa
monoamine oxidase A
chr7_-_83550258 0.234 ENSMUST00000177929.1
Gm10610
predicted gene 10610
chr16_-_45724600 0.228 ENSMUST00000096057.4
Tagln3
transgelin 3
chr6_+_37870786 0.226 ENSMUST00000120428.1
ENSMUST00000031859.7
Trim24

tripartite motif-containing 24

chr14_+_64589802 0.213 ENSMUST00000180610.1
A930011O12Rik
RIKEN cDNA A930011O12 gene
chr18_+_55057557 0.187 ENSMUST00000181765.1
Gm4221
predicted gene 4221
chr2_+_36230426 0.168 ENSMUST00000062069.5
Ptgs1
prostaglandin-endoperoxide synthase 1
chr4_+_102589687 0.164 ENSMUST00000097949.4
ENSMUST00000106901.1
Pde4b

phosphodiesterase 4B, cAMP specific

chr16_-_50330987 0.162 ENSMUST00000114488.1
Bbx
bobby sox homolog (Drosophila)
chr18_-_75697639 0.158 ENSMUST00000165559.1
Ctif
CBP80/20-dependent translation initiation factor
chrM_+_14138 0.153 ENSMUST00000082421.1
mt-Cytb
mitochondrially encoded cytochrome b
chr1_-_132367879 0.119 ENSMUST00000142609.1
Tmcc2
transmembrane and coiled-coil domains 2
chr6_+_63255971 0.116 ENSMUST00000159561.1
ENSMUST00000095852.3
Grid2

glutamate receptor, ionotropic, delta 2

chr14_+_54431597 0.101 ENSMUST00000089688.4
Mmp14
matrix metallopeptidase 14 (membrane-inserted)
chr2_+_110597298 0.096 ENSMUST00000045972.6
ENSMUST00000111026.2
Slc5a12

solute carrier family 5 (sodium/glucose cotransporter), member 12

chr7_+_35802593 0.088 ENSMUST00000052454.2
E130304I02Rik
RIKEN cDNA E130304I02 gene
chr18_-_10706688 0.086 ENSMUST00000002549.7
ENSMUST00000117726.1
ENSMUST00000117828.1
Abhd3


abhydrolase domain containing 3


chr6_+_134640940 0.083 ENSMUST00000062755.8
Loh12cr1
loss of heterozygosity, 12, chromosomal region 1 homolog (human)
chr19_+_55895508 0.073 ENSMUST00000111646.1
Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr11_+_102285161 0.068 ENSMUST00000156326.1
Tmub2
transmembrane and ubiquitin-like domain containing 2
chr19_-_41933276 0.053 ENSMUST00000075280.4
ENSMUST00000112123.2
Exosc1

exosome component 1

chr10_-_76110956 0.050 ENSMUST00000120757.1
Slc5a4b
solute carrier family 5 (neutral amino acid transporters, system A), member 4b
chr10_+_23894688 0.033 ENSMUST00000041416.7
Vnn1
vanin 1
chr2_-_164171113 0.028 ENSMUST00000045196.3
Kcns1
K+ voltage-gated channel, subfamily S, 1
chr18_-_3281036 0.016 ENSMUST00000049942.6
ENSMUST00000139537.1
ENSMUST00000124747.1
Crem


cAMP responsive element modulator



Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.0 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.4 1.5 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.3 4.6 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.3 2.2 GO:1901162 serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.2 1.0 GO:0046619 optic placode formation involved in camera-type eye formation(GO:0046619)
0.2 0.7 GO:2000564 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.2 0.6 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.2 0.8 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.1 0.7 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.1 0.6 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.1 5.4 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1 0.9 GO:0098707 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.1 0.3 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.1 0.6 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.1 0.4 GO:0051012 microtubule sliding(GO:0051012) negative regulation of nonmotile primary cilium assembly(GO:1902856)
0.1 0.5 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.1 0.3 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.1 0.4 GO:0000414 regulation of histone H3-K36 methylation(GO:0000414)
0.1 0.2 GO:0042420 dopamine catabolic process(GO:0042420)
0.0 0.3 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)
0.0 0.2 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.0 0.3 GO:0030242 pexophagy(GO:0030242)
0.0 0.2 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.0 0.2 GO:0033762 response to glucagon(GO:0033762)
0.0 0.3 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.3 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.5 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.0 0.1 GO:0051895 negative regulation of focal adhesion assembly(GO:0051895)
0.0 0.8 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 2.9 GO:0030308 negative regulation of cell growth(GO:0030308)
0.0 1.1 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 0.2 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.4 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 0.4 GO:0007608 sensory perception of smell(GO:0007608)
0.0 0.8 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 0.1 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
0.0 0.1 GO:1904659 glucose transmembrane transport(GO:1904659)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 5.4 GO:0042581 specific granule(GO:0042581)
0.2 0.6 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.1 0.9 GO:0097433 dense body(GO:0097433)
0.1 0.7 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.2 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 1.8 GO:0031672 A band(GO:0031672)
0.0 0.3 GO:0033503 HULC complex(GO:0033503)
0.0 0.2 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.8 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.3 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.3 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 0.9 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.4 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 1.5 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.1 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 0.2 GO:0045275 respiratory chain complex III(GO:0045275)
0.0 3.0 GO:0030426 growth cone(GO:0030426)
0.0 0.3 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.6 GO:0016235 aggresome(GO:0016235)
0.0 0.1 GO:0071664 beta-catenin-TCF7L2 complex(GO:0070369) catenin-TCF7L2 complex(GO:0071664)
0.0 1.0 GO:0005913 cell-cell adherens junction(GO:0005913)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.2 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.2 1.5 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 0.9 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.1 1.0 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.1 4.4 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 0.7 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.1 1.5 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 0.2 GO:0051378 primary amine oxidase activity(GO:0008131) serotonin binding(GO:0051378)
0.1 0.4 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 0.3 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 0.6 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.8 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.6 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.2 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.7 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.1 GO:0052740 phosphatidylserine 1-acylhydrolase activity(GO:0052739) 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.0 0.8 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.3 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.0 6.1 GO:0008017 microtubule binding(GO:0008017)
0.0 0.2 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.2 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.1 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 3.9 GO:0003924 GTPase activity(GO:0003924)
0.0 0.5 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 0.4 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.5 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.6 GO:0070888 E-box binding(GO:0070888)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.6 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 4.4 PID_ARF6_PATHWAY Arf6 signaling events
0.0 1.0 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.2 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 1.0 REACTOME_PROLONGED_ERK_ACTIVATION_EVENTS Genes involved in Prolonged ERK activation events
0.0 3.7 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.0 1.5 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 4.4 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.6 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.2 REACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.3 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation