Motif ID: Pbx1_Pbx3

Z-value: 1.252

Transcription factors associated with Pbx1_Pbx3:

Gene SymbolEntrez IDGene Name
Pbx1 ENSMUSG00000052534.9 Pbx1
Pbx3 ENSMUSG00000038718.9 Pbx3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pbx1mm10_v2_chr1_-_168432270_168432347-0.202.2e-01Click!
Pbx3mm10_v2_chr2_-_34372004_343720440.105.2e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Pbx1_Pbx3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_63711969 8.852 ENSMUST00000154323.1
Smad3
SMAD family member 3
chr17_+_85620816 7.879 ENSMUST00000175898.2
Six3
sine oculis-related homeobox 3
chr13_+_15463837 6.716 ENSMUST00000110510.3
Gli3
GLI-Kruppel family member GLI3
chr19_+_55741810 6.518 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr2_-_36104060 6.230 ENSMUST00000112961.3
ENSMUST00000112966.3
Lhx6

LIM homeobox protein 6

chrX_-_60893430 5.587 ENSMUST00000135107.2
Sox3
SRY-box containing gene 3
chr16_+_30065333 5.523 ENSMUST00000023171.7
Hes1
hairy and enhancer of split 1 (Drosophila)
chr17_+_83215271 5.062 ENSMUST00000170794.1
Pkdcc
protein kinase domain containing, cytoplasmic
chr17_+_85621017 4.806 ENSMUST00000162695.2
Six3
sine oculis-related homeobox 3
chr4_-_3938354 4.329 ENSMUST00000003369.3
Plag1
pleiomorphic adenoma gene 1
chr17_-_85688252 4.302 ENSMUST00000024947.7
ENSMUST00000163568.2
Six2

sine oculis-related homeobox 2

chr4_-_43523388 4.242 ENSMUST00000107913.3
ENSMUST00000030184.5
Tpm2

tropomyosin 2, beta

chrX_-_141474034 4.175 ENSMUST00000101205.2
Col4a6
collagen, type IV, alpha 6
chr17_-_70853482 4.124 ENSMUST00000118283.1
Tgif1
TGFB-induced factor homeobox 1
chr11_-_19018956 3.841 ENSMUST00000068264.7
ENSMUST00000144988.1
ENSMUST00000185131.1
Meis1


Meis homeobox 1


chr14_-_48667508 3.693 ENSMUST00000144465.1
ENSMUST00000133479.1
ENSMUST00000119070.1
ENSMUST00000152018.1
Otx2



orthodenticle homolog 2 (Drosophila)



chr19_-_9899450 3.684 ENSMUST00000025562.7
Incenp
inner centromere protein
chr13_-_64153194 3.646 ENSMUST00000059817.4
ENSMUST00000117241.1
Zfp367

zinc finger protein 367

chr8_-_115707778 3.598 ENSMUST00000109104.1
Maf
avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog
chr11_-_22001605 3.591 ENSMUST00000006071.7
Otx1
orthodenticle homolog 1 (Drosophila)
chr14_-_61037937 3.515 ENSMUST00000111236.2
Tnfrsf19
tumor necrosis factor receptor superfamily, member 19
chr5_-_67427794 3.508 ENSMUST00000169190.1
Bend4
BEN domain containing 4
chr14_+_99046406 3.489 ENSMUST00000022656.6
Bora
bora, aurora kinase A activator
chr14_-_122465677 3.318 ENSMUST00000039118.6
Zic5
zinc finger protein of the cerebellum 5
chr4_+_11579647 3.314 ENSMUST00000180239.1
Fsbp
fibrinogen silencer binding protein
chr10_-_42583628 3.309 ENSMUST00000019938.4
Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr4_-_43523746 3.238 ENSMUST00000150592.1
Tpm2
tropomyosin 2, beta
chr19_-_12501996 3.216 ENSMUST00000045521.7
Dtx4
deltex 4 homolog (Drosophila)
chr3_+_37639945 3.052 ENSMUST00000108109.1
ENSMUST00000038569.1
Spry1

sprouty homolog 1 (Drosophila)

chr3_+_37639985 2.951 ENSMUST00000108107.1
Spry1
sprouty homolog 1 (Drosophila)
chr4_-_151044564 2.948 ENSMUST00000103204.4
Per3
period circadian clock 3
chr5_+_103425181 2.912 ENSMUST00000048957.9
Ptpn13
protein tyrosine phosphatase, non-receptor type 13
chr11_-_19018714 2.895 ENSMUST00000177417.1
Meis1
Meis homeobox 1
chr4_+_3938888 2.830 ENSMUST00000121110.1
ENSMUST00000108386.1
ENSMUST00000149544.1
Chchd7


coiled-coil-helix-coiled-coil-helix domain containing 7


chrX_+_58030622 2.797 ENSMUST00000088627.4
Zic3
zinc finger protein of the cerebellum 3
chr4_-_43523595 2.704 ENSMUST00000107914.3
Tpm2
tropomyosin 2, beta
chr17_-_56830916 2.681 ENSMUST00000002444.7
ENSMUST00000086801.5
Rfx2

regulatory factor X, 2 (influences HLA class II expression)

chr11_-_87108656 2.592 ENSMUST00000051395.8
Prr11
proline rich 11
chr19_+_55742242 2.517 ENSMUST00000111652.1
ENSMUST00000111649.1
ENSMUST00000111651.1
ENSMUST00000111653.1
ENSMUST00000111656.1
ENSMUST00000127233.1
ENSMUST00000153888.1
Tcf7l2






transcription factor 7 like 2, T cell specific, HMG box






chr17_+_47596061 2.436 ENSMUST00000182539.1
Ccnd3
cyclin D3
chr6_+_108660772 2.387 ENSMUST00000163617.1
Bhlhe40
basic helix-loop-helix family, member e40
chr5_-_100500592 2.347 ENSMUST00000149714.1
ENSMUST00000046154.5
Lin54

lin-54 homolog (C. elegans)

chr19_+_55894508 2.340 ENSMUST00000142291.1
Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr2_+_91257323 2.283 ENSMUST00000111349.2
ENSMUST00000131711.1
Pacsin3

protein kinase C and casein kinase substrate in neurons 3

chr8_+_23411490 2.191 ENSMUST00000033952.7
Sfrp1
secreted frizzled-related protein 1
chr18_-_77047243 2.176 ENSMUST00000137354.1
ENSMUST00000137498.1
Katnal2

katanin p60 subunit A-like 2

chr4_-_129189600 2.155 ENSMUST00000117497.1
ENSMUST00000117350.1
S100pbp

S100P binding protein

chr4_-_129189646 2.145 ENSMUST00000106059.1
S100pbp
S100P binding protein
chr9_-_21760275 2.143 ENSMUST00000098942.4
Spc24
SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr4_-_129189512 2.064 ENSMUST00000117965.1
ENSMUST00000106061.2
ENSMUST00000072431.6
S100pbp


S100P binding protein


chr4_+_3938904 2.044 ENSMUST00000120732.1
ENSMUST00000041122.4
ENSMUST00000121651.1
ENSMUST00000121210.1
ENSMUST00000119307.1
ENSMUST00000123769.1
Chchd7





coiled-coil-helix-coiled-coil-helix domain containing 7





chr3_-_53657339 1.980 ENSMUST00000091137.4
Frem2
Fras1 related extracellular matrix protein 2
chrX_-_52165252 1.961 ENSMUST00000033450.2
Gpc4
glypican 4
chr9_+_106281061 1.957 ENSMUST00000072206.6
Poc1a
POC1 centriolar protein homolog A (Chlamydomonas)
chr18_-_77047282 1.918 ENSMUST00000154665.1
ENSMUST00000026486.6
ENSMUST00000123650.1
ENSMUST00000126153.1
Katnal2



katanin p60 subunit A-like 2



chr2_+_109917639 1.848 ENSMUST00000046548.7
ENSMUST00000111037.2
Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr9_+_122951051 1.740 ENSMUST00000040717.5
Kif15
kinesin family member 15
chrX_-_109013389 1.731 ENSMUST00000033597.8
Hmgn5
high-mobility group nucleosome binding domain 5
chr2_+_27886416 1.718 ENSMUST00000028280.7
Col5a1
collagen, type V, alpha 1
chr10_-_41809607 1.717 ENSMUST00000019951.9
Cep57l1
centrosomal protein 57-like 1
chr9_-_37147257 1.710 ENSMUST00000039674.5
ENSMUST00000080754.5
Pknox2

Pbx/knotted 1 homeobox 2

chr5_-_115436508 1.651 ENSMUST00000078701.3
4930430O22Rik
RIKEN cDNA 4930430O22 gene
chr17_+_31564749 1.641 ENSMUST00000175806.1
ENSMUST00000097352.3
Pknox1

Pbx/knotted 1 homeobox

chrX_+_110814390 1.640 ENSMUST00000078229.3
Pou3f4
POU domain, class 3, transcription factor 4
chr11_-_115813621 1.592 ENSMUST00000041684.4
ENSMUST00000156812.1
Caskin2

CASK-interacting protein 2

chr3_-_154328634 1.559 ENSMUST00000167744.1
Lhx8
LIM homeobox protein 8
chr3_-_8667033 1.559 ENSMUST00000042412.3
Hey1
hairy/enhancer-of-split related with YRPW motif 1
chr10_-_81600857 1.534 ENSMUST00000151858.1
ENSMUST00000142948.1
ENSMUST00000072020.2
Tle6


transducin-like enhancer of split 6, homolog of Drosophila E(spl)


chr2_-_116065047 1.531 ENSMUST00000028639.6
ENSMUST00000102538.4
Meis2

Meis homeobox 2

chr5_-_51553896 1.524 ENSMUST00000132734.1
Ppargc1a
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
chr9_-_100546053 1.519 ENSMUST00000116522.1
Nck1
non-catalytic region of tyrosine kinase adaptor protein 1
chr5_-_21701332 1.501 ENSMUST00000115217.1
ENSMUST00000060899.8
Napepld

N-acyl phosphatidylethanolamine phospholipase D

chr13_-_106936907 1.496 ENSMUST00000080856.7
Ipo11
importin 11
chr6_+_34476207 1.488 ENSMUST00000045372.5
ENSMUST00000138668.1
ENSMUST00000139067.1
Bpgm


2,3-bisphosphoglycerate mutase


chr10_-_40302186 1.466 ENSMUST00000099945.4
Amd1
S-adenosylmethionine decarboxylase 1
chr2_+_116067213 1.452 ENSMUST00000152412.1
G630016G05Rik
RIKEN cDNA G630016G05 gene
chr13_-_119408985 1.437 ENSMUST00000099149.3
ENSMUST00000069902.6
ENSMUST00000109204.1
Nnt


nicotinamide nucleotide transhydrogenase


chr4_+_129820198 1.409 ENSMUST00000030578.7
Ptp4a2
protein tyrosine phosphatase 4a2
chr3_+_127633134 1.398 ENSMUST00000029587.7
Neurog2
neurogenin 2
chr9_+_113930934 1.389 ENSMUST00000084885.5
ENSMUST00000009885.7
Ubp1

upstream binding protein 1

chr17_-_30612613 1.372 ENSMUST00000167624.1
ENSMUST00000024823.6
Glo1

glyoxalase 1

chr19_+_55741884 1.367 ENSMUST00000111658.3
ENSMUST00000111654.1
Tcf7l2

transcription factor 7 like 2, T cell specific, HMG box

chr14_-_65425453 1.315 ENSMUST00000059339.5
Pnoc
prepronociceptin
chr16_+_21204755 1.308 ENSMUST00000006112.6
Ephb3
Eph receptor B3
chr14_+_46832127 1.229 ENSMUST00000068532.8
Cgrrf1
cell growth regulator with ring finger domain 1
chr9_-_95845215 1.228 ENSMUST00000093800.2
Pls1
plastin 1 (I-isoform)
chr11_-_80080928 1.216 ENSMUST00000103233.3
ENSMUST00000061283.8
Crlf3

cytokine receptor-like factor 3

chr18_+_60925612 1.207 ENSMUST00000102888.3
ENSMUST00000025519.4
Camk2a

calcium/calmodulin-dependent protein kinase II alpha

chr8_-_116732991 1.191 ENSMUST00000109102.2
Cdyl2
chromodomain protein, Y chromosome-like 2
chr12_-_54986363 1.190 ENSMUST00000173433.1
ENSMUST00000173803.1
Baz1a
Gm20403
bromodomain adjacent to zinc finger domain 1A
predicted gene 20403
chr7_-_110061319 1.171 ENSMUST00000098110.2
AA474408
expressed sequence AA474408
chr4_+_98546919 1.169 ENSMUST00000030290.7
Inadl
InaD-like (Drosophila)
chr10_-_10558199 1.161 ENSMUST00000019974.3
Rab32
RAB32, member RAS oncogene family
chr19_+_55742056 1.145 ENSMUST00000111659.2
Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr4_+_41760454 1.127 ENSMUST00000108040.1
Il11ra1
interleukin 11 receptor, alpha chain 1
chr4_+_98546710 1.126 ENSMUST00000102792.3
Inadl
InaD-like (Drosophila)
chr10_-_13324250 1.125 ENSMUST00000105543.1
Phactr2
phosphatase and actin regulator 2
chr18_-_84086379 1.099 ENSMUST00000060303.8
Tshz1
teashirt zinc finger family member 1
chr13_+_91461050 1.090 ENSMUST00000004094.8
ENSMUST00000042122.8
Ssbp2

single-stranded DNA binding protein 2

chr2_+_172549581 1.037 ENSMUST00000030391.2
Tfap2c
transcription factor AP-2, gamma
chr14_+_25694170 1.033 ENSMUST00000022419.6
Ppif
peptidylprolyl isomerase F (cyclophilin F)
chrX_+_136822671 1.027 ENSMUST00000033800.6
Plp1
proteolipid protein (myelin) 1
chr16_-_31201150 1.024 ENSMUST00000058033.7
Acap2
ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
chr3_+_88579602 1.007 ENSMUST00000035785.7
Ssr2
signal sequence receptor, beta
chr3_-_5576233 0.996 ENSMUST00000059021.4
Pex2
peroxisomal biogenesis factor 2
chr12_-_54986328 0.991 ENSMUST00000038926.6
Baz1a
bromodomain adjacent to zinc finger domain 1A
chr3_-_5576111 0.986 ENSMUST00000165309.1
ENSMUST00000164828.1
ENSMUST00000071280.5
Pex2


peroxisomal biogenesis factor 2


chr15_-_83464570 0.985 ENSMUST00000056177.6
Pacsin2
protein kinase C and casein kinase substrate in neurons 2
chr4_+_59581563 0.978 ENSMUST00000030078.5
Hsdl2
hydroxysteroid dehydrogenase like 2
chr12_-_83921809 0.951 ENSMUST00000135962.1
ENSMUST00000155112.1
ENSMUST00000136848.1
ENSMUST00000126943.1
Numb



numb gene homolog (Drosophila)



chr6_-_54593139 0.943 ENSMUST00000046520.6
Fkbp14
FK506 binding protein 14
chr11_-_89538556 0.942 ENSMUST00000169201.1
Ankfn1
ankyrin-repeat and fibronectin type III domain containing 1
chr2_-_125506385 0.928 ENSMUST00000028633.6
Fbn1
fibrillin 1
chr16_+_64851991 0.919 ENSMUST00000067744.7
Cggbp1
CGG triplet repeat binding protein 1
chr5_+_92897981 0.916 ENSMUST00000113051.2
Shroom3
shroom family member 3
chr14_-_31640878 0.898 ENSMUST00000167066.1
ENSMUST00000127204.2
ENSMUST00000022437.8
Hacl1


2-hydroxyacyl-CoA lyase 1


chr8_+_75033673 0.896 ENSMUST00000078847.5
ENSMUST00000165630.1
Tom1

target of myb1 homolog (chicken)

chr11_+_16951371 0.893 ENSMUST00000109635.1
ENSMUST00000061327.1
Fbxo48

F-box protein 48

chr8_+_105900421 0.892 ENSMUST00000049699.8
Pskh1
protein serine kinase H1
chr12_-_83921899 0.890 ENSMUST00000117217.1
Numb
numb gene homolog (Drosophila)
chr10_+_77978524 0.871 ENSMUST00000105397.3
ENSMUST00000105398.1
1810043G02Rik

RIKEN cDNA 1810043G02 gene

chr3_-_51560816 0.859 ENSMUST00000037141.7
Setd7
SET domain containing (lysine methyltransferase) 7
chr4_+_98395768 0.845 ENSMUST00000041284.3
Inadl
InaD-like (Drosophila)
chr11_-_106998483 0.843 ENSMUST00000124541.1
Kpna2
karyopherin (importin) alpha 2
chr15_-_83464595 0.839 ENSMUST00000171436.1
Pacsin2
protein kinase C and casein kinase substrate in neurons 2
chr8_-_46152159 0.834 ENSMUST00000110378.2
Snx25
sorting nexin 25
chr4_-_115939923 0.828 ENSMUST00000124071.2
ENSMUST00000084338.6
Dmbx1

diencephalon/mesencephalon homeobox 1

chr4_-_151057933 0.820 ENSMUST00000030797.3
Vamp3
vesicle-associated membrane protein 3
chr1_-_75506331 0.798 ENSMUST00000113567.2
ENSMUST00000113565.2
Obsl1

obscurin-like 1

chr5_+_115011111 0.792 ENSMUST00000031530.5
Sppl3
signal peptide peptidase 3
chr15_-_8099182 0.788 ENSMUST00000045766.6
Wdr70
WD repeat domain 70
chr4_+_98395817 0.783 ENSMUST00000107033.1
ENSMUST00000107034.1
Inadl

InaD-like (Drosophila)

chr3_+_37312514 0.774 ENSMUST00000057975.7
ENSMUST00000108121.3
Bbs12

Bardet-Biedl syndrome 12 (human)

chr11_+_60537978 0.769 ENSMUST00000044250.3
Alkbh5
alkB, alkylation repair homolog 5 (E. coli)
chr4_+_59581645 0.766 ENSMUST00000107528.1
Hsdl2
hydroxysteroid dehydrogenase like 2
chr17_+_25240166 0.759 ENSMUST00000063574.6
Tsr3
TSR3 20S rRNA accumulation
chr11_-_96005872 0.758 ENSMUST00000013559.2
Igf2bp1
insulin-like growth factor 2 mRNA binding protein 1
chrX_+_136822781 0.756 ENSMUST00000113085.1
Plp1
proteolipid protein (myelin) 1
chrX_-_36874111 0.751 ENSMUST00000047486.5
C330007P06Rik
RIKEN cDNA C330007P06 gene
chr12_+_72939724 0.737 ENSMUST00000021519.5
Six6
sine oculis-related homeobox 6
chr2_-_116067391 0.731 ENSMUST00000140185.1
2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr14_+_54894133 0.714 ENSMUST00000116476.2
ENSMUST00000022808.7
ENSMUST00000150975.1
Pabpn1


poly(A) binding protein, nuclear 1


chr7_-_18910391 0.708 ENSMUST00000150065.1
ENSMUST00000098780.3
Ccdc61

coiled-coil domain containing 61

chr7_-_18910377 0.697 ENSMUST00000139077.1
Ccdc61
coiled-coil domain containing 61
chr7_+_122289297 0.694 ENSMUST00000064989.5
ENSMUST00000064921.4
Prkcb

protein kinase C, beta

chr1_-_183147461 0.694 ENSMUST00000171366.1
Disp1
dispatched homolog 1 (Drosophila)
chrX_-_8074720 0.694 ENSMUST00000115636.3
ENSMUST00000115638.3
Suv39h1

suppressor of variegation 3-9 homolog 1 (Drosophila)

chr17_-_22867075 0.691 ENSMUST00000150092.1
Zfp945
zinc finger protein 945
chr2_+_110017879 0.689 ENSMUST00000150183.2
Ccdc34
coiled-coil domain containing 34
chr17_-_56290499 0.689 ENSMUST00000019726.6
Plin3
perilipin 3
chr8_+_124231359 0.681 ENSMUST00000034458.8
Galnt2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2
chr2_+_110017806 0.668 ENSMUST00000028580.5
Ccdc34
coiled-coil domain containing 34
chrX_+_106187100 0.662 ENSMUST00000081593.6
Pgk1
phosphoglycerate kinase 1
chrX_-_73930751 0.659 ENSMUST00000155597.1
ENSMUST00000114379.1
Renbp

renin binding protein

chr2_+_158794807 0.658 ENSMUST00000029186.7
ENSMUST00000109478.2
ENSMUST00000156893.1
Dhx35


DEAH (Asp-Glu-Ala-His) box polypeptide 35


chr10_+_79854658 0.647 ENSMUST00000171599.1
ENSMUST00000095457.4
Ptbp1

polypyrimidine tract binding protein 1

chr10_+_79854618 0.641 ENSMUST00000165704.1
Ptbp1
polypyrimidine tract binding protein 1
chr15_+_99702278 0.635 ENSMUST00000023759.4
Smarcd1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
chr19_-_44069526 0.627 ENSMUST00000170801.1
Erlin1
ER lipid raft associated 1
chr11_-_100441795 0.622 ENSMUST00000107398.1
Nt5c3b
5'-nucleotidase, cytosolic IIIB
chr17_-_24960620 0.611 ENSMUST00000024981.7
Hn1l
hematological and neurological expressed 1-like
chr10_+_20148457 0.605 ENSMUST00000020173.8
Map7
microtubule-associated protein 7
chr18_+_60925644 0.600 ENSMUST00000115297.1
Camk2a
calcium/calmodulin-dependent protein kinase II alpha
chr10_-_78009737 0.575 ENSMUST00000020522.8
Pfkl
phosphofructokinase, liver, B-type
chr5_-_138172383 0.574 ENSMUST00000000505.9
Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
chr11_+_70562898 0.571 ENSMUST00000102559.4
Mink1
misshapen-like kinase 1 (zebrafish)
chr11_+_23256001 0.570 ENSMUST00000020538.6
ENSMUST00000109551.1
ENSMUST00000102870.1
ENSMUST00000102869.1
Xpo1



exportin 1, CRM1 homolog (yeast)



chr1_+_136624901 0.565 ENSMUST00000047734.8
ENSMUST00000112046.1
Zfp281

zinc finger protein 281

chr14_+_21500879 0.563 ENSMUST00000182964.1
Kat6b
K(lysine) acetyltransferase 6B
chr3_+_88206786 0.558 ENSMUST00000181134.1
ENSMUST00000181550.1
Gm3764

predicted gene 3764

chr13_+_94173992 0.551 ENSMUST00000121618.1
Lhfpl2
lipoma HMGIC fusion partner-like 2
chr3_+_89215192 0.541 ENSMUST00000142051.1
ENSMUST00000119084.1
Thbs3

thrombospondin 3

chr3_+_89215170 0.532 ENSMUST00000029682.4
Thbs3
thrombospondin 3
chr1_+_75192143 0.532 ENSMUST00000152233.2
ENSMUST00000127625.2
Ankzf1

ankyrin repeat and zinc finger domain containing 1

chr13_+_44730726 0.532 ENSMUST00000173704.1
ENSMUST00000044608.7
ENSMUST00000173367.1
Jarid2


jumonji, AT rich interactive domain 2


chr6_-_49214954 0.531 ENSMUST00000031838.7
Igf2bp3
insulin-like growth factor 2 mRNA binding protein 3
chr3_-_75956888 0.531 ENSMUST00000038563.7
ENSMUST00000167078.1
ENSMUST00000117242.1
Golim4


golgi integral membrane protein 4


chr2_-_174464063 0.529 ENSMUST00000016396.7
Atp5e
ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit
chr11_+_70562840 0.524 ENSMUST00000072237.6
ENSMUST00000072873.7
Mink1

misshapen-like kinase 1 (zebrafish)

chr4_+_140961203 0.522 ENSMUST00000010007.8
Sdhb
succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
chr3_-_107333289 0.512 ENSMUST00000061772.9
Rbm15
RNA binding motif protein 15
chr17_-_25240112 0.510 ENSMUST00000038973.6
ENSMUST00000115154.4
Gnptg

N-acetylglucosamine-1-phosphotransferase, gamma subunit

chr16_+_87354185 0.510 ENSMUST00000054442.4
ENSMUST00000118310.1
ENSMUST00000120284.1
ENSMUST00000118115.1
N6amt1



N-6 adenine-specific DNA methyltransferase 1 (putative)



chr14_+_31641051 0.506 ENSMUST00000090147.6
Btd
biotinidase
chr17_-_46031813 0.503 ENSMUST00000024747.7
Vegfa
vascular endothelial growth factor A
chr3_+_133338936 0.498 ENSMUST00000150386.1
ENSMUST00000125858.1
Ppa2

pyrophosphatase (inorganic) 2

chr7_+_89632689 0.497 ENSMUST00000032856.6
Me3
malic enzyme 3, NADP(+)-dependent, mitochondrial
chr13_-_71963713 0.490 ENSMUST00000077337.8
Irx1
Iroquois related homeobox 1 (Drosophila)
chr11_-_82890541 0.489 ENSMUST00000092844.6
ENSMUST00000021033.9
ENSMUST00000018985.8
Rad51d


RAD51 homolog D


chr10_-_111997204 0.488 ENSMUST00000074805.5
Glipr1
GLI pathogenesis-related 1 (glioma)
chr4_-_137048695 0.483 ENSMUST00000049583.7
Zbtb40
zinc finger and BTB domain containing 40
chr10_-_54075730 0.482 ENSMUST00000105469.1
ENSMUST00000003843.8
Man1a

mannosidase 1, alpha

chrX_-_73930834 0.477 ENSMUST00000116578.1
Renbp
renin binding protein
chr8_+_71464910 0.470 ENSMUST00000048914.6
Mrpl34
mitochondrial ribosomal protein L34
chr2_+_119325784 0.468 ENSMUST00000102517.3
Dll4
delta-like 4 (Drosophila)
chr19_-_44069736 0.461 ENSMUST00000172041.1
ENSMUST00000071698.6
ENSMUST00000112028.3
Erlin1


ER lipid raft associated 1


chr16_+_17233560 0.456 ENSMUST00000090190.5
ENSMUST00000115698.2
Hic2

hypermethylated in cancer 2

chr1_-_91413163 0.444 ENSMUST00000086851.1
Hes6
hairy and enhancer of split 6
chr7_-_31054815 0.436 ENSMUST00000071697.4
ENSMUST00000108110.3
Fxyd1

FXYD domain-containing ion transport regulator 1

chr2_-_126618655 0.435 ENSMUST00000028838.4
Hdc
histidine decarboxylase

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 12.7 GO:0097402 neuroblast migration(GO:0097402)
3.0 8.9 GO:0044413 regulation of lung blood pressure(GO:0014916) evasion or tolerance of host defenses by virus(GO:0019049) positive regulation of transforming growth factor beta3 production(GO:0032916) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
2.2 6.7 GO:0060364 frontal suture morphogenesis(GO:0060364)
1.8 5.5 GO:0021557 oculomotor nerve development(GO:0021557)
1.7 13.9 GO:0048625 myoblast fate commitment(GO:0048625)
1.2 6.0 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
1.1 4.3 GO:0097168 condensed mesenchymal cell proliferation(GO:0072137) mesenchymal stem cell proliferation(GO:0097168)
1.0 6.2 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.9 3.7 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.8 5.1 GO:0090005 negative regulation of Golgi to plasma membrane protein transport(GO:0042997) negative regulation of establishment of protein localization to plasma membrane(GO:0090005)
0.7 2.2 GO:1904956 regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.7 3.6 GO:0048852 diencephalon morphogenesis(GO:0048852)
0.7 3.3 GO:0021764 amygdala development(GO:0021764)
0.6 1.8 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.6 1.8 GO:0030862 neuroblast division in subventricular zone(GO:0021849) positive regulation of polarized epithelial cell differentiation(GO:0030862)
0.6 1.7 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.5 1.6 GO:0072049 comma-shaped body morphogenesis(GO:0072049)
0.5 1.5 GO:0002191 cap-dependent translational initiation(GO:0002191)
0.5 1.5 GO:0006597 spermine biosynthetic process(GO:0006597)
0.5 2.8 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.4 1.3 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.4 1.2 GO:0001951 intestinal D-glucose absorption(GO:0001951) terminal web assembly(GO:1902896)
0.4 2.0 GO:0003431 growth plate cartilage chondrocyte development(GO:0003431)
0.4 1.5 GO:2000182 regulation of progesterone biosynthetic process(GO:2000182)
0.4 1.1 GO:0060023 soft palate development(GO:0060023)
0.3 1.0 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.3 1.0 GO:1902445 regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445)
0.3 0.9 GO:1903011 negative regulation of bone development(GO:1903011)
0.3 6.7 GO:0060044 negative regulation of cardiac muscle cell proliferation(GO:0060044)
0.3 1.5 GO:1903998 regulation of eating behavior(GO:1903998)
0.3 4.3 GO:0060736 prostate gland growth(GO:0060736)
0.3 5.6 GO:0007530 sex determination(GO:0007530)
0.3 0.8 GO:1902336 neuropilin signaling pathway(GO:0038189) VEGF-activated neuropilin signaling pathway(GO:0038190) positive regulation of retinal ganglion cell axon guidance(GO:1902336)
0.3 1.1 GO:0072272 proximal/distal pattern formation involved in metanephric nephron development(GO:0072272)
0.3 1.1 GO:0060346 bone trabecula formation(GO:0060346)
0.3 4.2 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.2 4.2 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.2 0.7 GO:1904245 regulation of polynucleotide adenylyltransferase activity(GO:1904245)
0.2 1.2 GO:1903232 melanosome assembly(GO:1903232)
0.2 2.9 GO:0045187 regulation of circadian sleep/wake cycle, sleep(GO:0045187)
0.2 1.3 GO:0043383 negative T cell selection(GO:0043383) negative thymic T cell selection(GO:0045060)
0.2 2.7 GO:0001675 acrosome assembly(GO:0001675)
0.2 1.6 GO:2001054 negative regulation of mesenchymal cell apoptotic process(GO:2001054)
0.2 0.8 GO:0035553 oxidative single-stranded RNA demethylation(GO:0035553)
0.2 1.8 GO:0038166 angiotensin-activated signaling pathway(GO:0038166)
0.2 0.9 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.2 1.4 GO:0045541 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.2 0.5 GO:0016256 N-glycan processing to lysosome(GO:0016256)
0.2 1.8 GO:0070836 caveola assembly(GO:0070836)
0.2 1.1 GO:0019262 N-acetylneuraminate catabolic process(GO:0019262)
0.2 1.3 GO:0050957 equilibrioception(GO:0050957)
0.2 0.8 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.2 0.5 GO:0072554 blood vessel lumenization(GO:0072554) negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.2 1.5 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.2 0.8 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.1 1.4 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.1 0.7 GO:0018242 protein O-linked glycosylation via serine(GO:0018242)
0.1 1.5 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.1 2.4 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.1 0.4 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.1 2.0 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.1 0.3 GO:0021506 anterior neuropore closure(GO:0021506) neuropore closure(GO:0021995)
0.1 0.4 GO:0036500 ATF6-mediated unfolded protein response(GO:0036500)
0.1 3.2 GO:0070306 lens fiber cell differentiation(GO:0070306)
0.1 1.8 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.1 0.8 GO:0008343 adult feeding behavior(GO:0008343)
0.1 1.3 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.1 0.7 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.1 2.3 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 0.8 GO:0051533 positive regulation of NFAT protein import into nucleus(GO:0051533)
0.1 0.4 GO:0001692 histamine metabolic process(GO:0001692) histidine metabolic process(GO:0006547) imidazole-containing compound catabolic process(GO:0052805)
0.1 0.9 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.1 0.3 GO:0090202 transcriptional activation by promoter-enhancer looping(GO:0071733) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899) gene looping(GO:0090202) dsDNA loop formation(GO:0090579)
0.1 3.5 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.1 1.3 GO:0046697 decidualization(GO:0046697)
0.1 0.5 GO:0051881 regulation of mitochondrial membrane potential(GO:0051881)
0.1 0.2 GO:1904580 regulation of intracellular mRNA localization(GO:1904580)
0.1 0.3 GO:0043686 co-translational protein modification(GO:0043686)
0.1 2.7 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.1 0.5 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.1 0.4 GO:1903795 regulation of inorganic anion transmembrane transport(GO:1903795)
0.1 0.4 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.1 0.5 GO:0006108 malate metabolic process(GO:0006108)
0.1 0.5 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.1 0.4 GO:0060576 intestinal epithelial cell development(GO:0060576)
0.1 0.3 GO:0001887 selenium compound metabolic process(GO:0001887) selenocysteine metabolic process(GO:0016259)
0.1 0.6 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.1 0.7 GO:0036123 histone H3-K9 dimethylation(GO:0036123)
0.1 1.0 GO:0036010 protein localization to endosome(GO:0036010)
0.1 0.7 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.1 0.3 GO:0097298 regulation of nucleus size(GO:0097298)
0.1 0.8 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.1 0.7 GO:0060539 diaphragm development(GO:0060539)
0.1 0.6 GO:0033327 Leydig cell differentiation(GO:0033327)
0.1 0.6 GO:0030388 fructose 6-phosphate metabolic process(GO:0006002) fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1 0.5 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.1 0.8 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 1.0 GO:0006613 cotranslational protein targeting to membrane(GO:0006613)
0.1 0.2 GO:1904684 negative regulation of metalloendopeptidase activity(GO:1904684)
0.1 0.5 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.1 0.6 GO:0006337 nucleosome disassembly(GO:0006337)
0.1 0.4 GO:0033147 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606) negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.1 0.7 GO:0031639 plasminogen activation(GO:0031639)
0.0 0.1 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.0 0.5 GO:0006105 succinate metabolic process(GO:0006105)
0.0 0.8 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.1 GO:0072086 specification of loop of Henle identity(GO:0072086)
0.0 1.4 GO:0006739 NADP metabolic process(GO:0006739)
0.0 0.1 GO:0050847 progesterone receptor signaling pathway(GO:0050847)
0.0 0.1 GO:0060681 branch elongation involved in ureteric bud branching(GO:0060681)
0.0 0.3 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 0.1 GO:0060672 negative regulation of keratinocyte differentiation(GO:0045617) epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
0.0 0.2 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
0.0 0.4 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.0 0.1 GO:1904207 chemokine (C-C motif) ligand 2 secretion(GO:0035926) regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.0 0.3 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 0.4 GO:0045199 maintenance of epithelial cell apical/basal polarity(GO:0045199)
0.0 1.3 GO:0048546 digestive tract morphogenesis(GO:0048546)
0.0 1.2 GO:1904894 positive regulation of JAK-STAT cascade(GO:0046427) positive regulation of STAT cascade(GO:1904894)
0.0 3.9 GO:0001843 neural tube closure(GO:0001843) tube closure(GO:0060606)
0.0 0.6 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.0 3.0 GO:0001942 hair follicle development(GO:0001942)
0.0 2.9 GO:0014066 regulation of phosphatidylinositol 3-kinase signaling(GO:0014066)
0.0 1.6 GO:0021884 forebrain neuron development(GO:0021884)
0.0 1.3 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 0.0 GO:0009794 regulation of mitotic cell cycle, embryonic(GO:0009794) mitotic cell cycle, embryonic(GO:0045448)
0.0 0.8 GO:0001921 positive regulation of receptor recycling(GO:0001921)
0.0 0.8 GO:0042755 eating behavior(GO:0042755)
0.0 0.2 GO:0006573 valine metabolic process(GO:0006573)
0.0 0.1 GO:0071455 cellular response to hyperoxia(GO:0071455)
0.0 0.3 GO:0045475 locomotor rhythm(GO:0045475)
0.0 0.5 GO:0006767 water-soluble vitamin metabolic process(GO:0006767)
0.0 7.9 GO:0007015 actin filament organization(GO:0007015)
0.0 0.3 GO:0046855 inositol phosphate dephosphorylation(GO:0046855)
0.0 1.5 GO:0045638 negative regulation of myeloid cell differentiation(GO:0045638)
0.0 0.1 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.0 2.9 GO:0000910 cytokinesis(GO:0000910)
0.0 1.0 GO:0030490 maturation of SSU-rRNA(GO:0030490)
0.0 0.2 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 1.9 GO:0030218 erythrocyte differentiation(GO:0030218)
0.0 0.2 GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518)
0.0 0.5 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.1 GO:0015862 uridine transport(GO:0015862)
0.0 2.2 GO:0007219 Notch signaling pathway(GO:0007219)
0.0 0.1 GO:0005513 detection of calcium ion(GO:0005513)
0.0 1.7 GO:0000070 mitotic sister chromatid segregation(GO:0000070)
0.0 0.4 GO:0006801 superoxide metabolic process(GO:0006801)
0.0 1.1 GO:0006261 DNA-dependent DNA replication(GO:0006261)
0.0 0.4 GO:0032728 positive regulation of interferon-beta production(GO:0032728)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 8.9 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
1.5 13.9 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
1.2 3.7 GO:0000801 central element(GO:0000801)
0.8 4.2 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.8 10.2 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.6 1.8 GO:0099573 glutamatergic postsynaptic density(GO:0099573)
0.6 1.7 GO:0005588 collagen type V trimer(GO:0005588)
0.5 2.2 GO:0008623 CHRAC(GO:0008623)
0.4 3.5 GO:0072687 meiotic spindle(GO:0072687)
0.4 1.2 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.4 2.1 GO:0031262 Ndc80 complex(GO:0031262)
0.3 1.6 GO:0001674 female germ cell nucleus(GO:0001674)
0.2 1.2 GO:1990357 terminal web(GO:1990357)
0.2 1.8 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.2 6.7 GO:0016592 mediator complex(GO:0016592)
0.2 0.8 GO:0071556 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.1 0.6 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.1 0.7 GO:0033553 rDNA heterochromatin(GO:0033553)
0.1 0.5 GO:0045283 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.1 0.8 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.1 0.7 GO:0005796 Golgi lumen(GO:0005796)
0.1 1.4 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 0.5 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.1 0.4 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.1 0.9 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.1 1.1 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 0.5 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.1 0.8 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.1 0.5 GO:0098799 outer mitochondrial membrane protein complex(GO:0098799)
0.1 0.4 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 0.6 GO:0005642 annulate lamellae(GO:0005642)
0.1 0.7 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 0.2 GO:0008091 spectrin(GO:0008091)
0.0 0.3 GO:0097255 R2TP complex(GO:0097255)
0.0 1.8 GO:0043209 myelin sheath(GO:0043209)
0.0 0.7 GO:0042555 MCM complex(GO:0042555)
0.0 2.4 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 4.0 GO:0016363 nuclear matrix(GO:0016363)
0.0 0.5 GO:0046930 pore complex(GO:0046930)
0.0 1.5 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 13.9 GO:0016607 nuclear speck(GO:0016607)
0.0 0.2 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.0 0.3 GO:0031415 NatA complex(GO:0031415)
0.0 1.7 GO:0045171 intercellular bridge(GO:0045171)
0.0 0.8 GO:0031430 M band(GO:0031430)
0.0 2.8 GO:0005604 basement membrane(GO:0005604)
0.0 1.7 GO:0005871 kinesin complex(GO:0005871)
0.0 0.1 GO:0033269 internode region of axon(GO:0033269)
0.0 0.5 GO:0045120 pronucleus(GO:0045120)
0.0 0.5 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.2 GO:0043219 flotillin complex(GO:0016600) lateral loop(GO:0043219)
0.0 0.8 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 2.0 GO:0000922 spindle pole(GO:0000922)
0.0 0.7 GO:0031526 brush border membrane(GO:0031526)
0.0 0.8 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.0 0.1 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 2.4 GO:0030496 midbody(GO:0030496)
0.0 0.3 GO:0036038 MKS complex(GO:0036038)
0.0 7.0 GO:0005667 transcription factor complex(GO:0005667)
0.0 3.5 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.3 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.8 GO:0005643 nuclear pore(GO:0005643)
0.0 0.8 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 3.3 GO:0016324 apical plasma membrane(GO:0016324)
0.0 0.5 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) large ribosomal subunit(GO:0015934)
0.0 0.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.0 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 0.6 GO:0000786 nucleosome(GO:0000786)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 8.9 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.7 14.1 GO:0045295 gamma-catenin binding(GO:0045295)
0.6 4.1 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.5 13.1 GO:0001222 transcription corepressor binding(GO:0001222)
0.5 1.6 GO:0035939 microsatellite binding(GO:0035939)
0.4 1.3 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.4 2.4 GO:0043426 MRF binding(GO:0043426)
0.4 1.2 GO:0035651 AP-1 adaptor complex binding(GO:0035650) AP-3 adaptor complex binding(GO:0035651)
0.4 1.5 GO:0019808 polyamine binding(GO:0019808)
0.3 11.0 GO:0008307 structural constituent of muscle(GO:0008307)
0.3 7.9 GO:0008432 JUN kinase binding(GO:0008432)
0.3 1.1 GO:0004921 interleukin-11 receptor activity(GO:0004921) interleukin-11 binding(GO:0019970)
0.3 0.8 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.2 1.9 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.2 1.3 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.2 1.3 GO:0001069 regulatory region RNA binding(GO:0001069)
0.2 0.8 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.2 1.3 GO:0001515 opioid peptide activity(GO:0001515)
0.2 1.5 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.2 1.8 GO:0045294 alpha-catenin binding(GO:0045294)
0.2 2.3 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.2 0.5 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177) 3 iron, 4 sulfur cluster binding(GO:0051538)
0.2 1.4 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.2 0.5 GO:0004473 malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.2 0.7 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.2 5.3 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.2 1.8 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 1.0 GO:0016018 cyclosporin A binding(GO:0016018)
0.1 0.6 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.1 0.5 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.1 0.5 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.1 1.7 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 2.0 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.1 0.4 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.1 1.6 GO:0003680 AT DNA binding(GO:0003680)
0.1 0.9 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.1 0.8 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.1 2.2 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 1.3 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.1 1.4 GO:0070888 E-box binding(GO:0070888)
0.1 0.8 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.1 4.5 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 0.3 GO:0004980 melanocortin receptor activity(GO:0004977) melanocyte-stimulating hormone receptor activity(GO:0004980)
0.1 1.1 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1 1.8 GO:0032794 GTPase activating protein binding(GO:0032794)
0.1 0.2 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.1 0.4 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.1 6.3 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 1.5 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.1 0.5 GO:0000150 recombinase activity(GO:0000150)
0.1 1.7 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 0.5 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.1 8.2 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 2.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 8.2 GO:0042826 histone deacetylase binding(GO:0042826)
0.1 3.2 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.1 1.1 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.1 0.9 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.1 0.6 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.1 0.3 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.1 1.0 GO:0070300 phosphatidic acid binding(GO:0070300)
0.1 0.9 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.1 0.9 GO:0035064 methylated histone binding(GO:0035064)
0.1 0.3 GO:0042731 PH domain binding(GO:0042731)
0.1 1.3 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 2.0 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.7 GO:0015197 peptide transporter activity(GO:0015197)
0.0 2.8 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.5 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.3 GO:0019841 retinol binding(GO:0019841)
0.0 18.0 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 0.9 GO:0030276 clathrin binding(GO:0030276)
0.0 0.1 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.0 1.1 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.2 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0 0.7 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.6 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.9 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 1.4 GO:0050661 NADP binding(GO:0050661)
0.0 1.0 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.2 GO:0034713 type I transforming growth factor beta receptor binding(GO:0034713)
0.0 0.2 GO:0034452 dynactin binding(GO:0034452)
0.0 0.7 GO:0050681 androgen receptor binding(GO:0050681)
0.0 1.9 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.4 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 1.1 GO:0032934 cholesterol binding(GO:0015485) sterol binding(GO:0032934)
0.0 0.6 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.5 GO:0008276 protein methyltransferase activity(GO:0008276)
0.0 0.3 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.6 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 0.1 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.2 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.0 0.5 GO:0005112 Notch binding(GO:0005112)
0.0 0.4 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.7 GO:0070063 RNA polymerase binding(GO:0070063)
0.0 0.1 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.5 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.6 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 0.1 GO:0044548 S100 protein binding(GO:0044548)
0.0 0.3 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.4 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.4 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.5 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0 1.6 GO:0051015 actin filament binding(GO:0051015)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 9.7 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.2 14.2 PID_AP1_PATHWAY AP-1 transcription factor network
0.2 7.2 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 2.8 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.1 8.8 PID_PLK1_PATHWAY PLK1 signaling events
0.1 5.4 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.1 6.9 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 0.7 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 1.8 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 6.4 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 2.5 PID_ARF6_PATHWAY Arf6 signaling events
0.1 2.5 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 2.2 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 2.3 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 3.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.4 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 1.1 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.6 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.6 PID_ATM_PATHWAY ATM pathway
0.0 1.2 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.3 PID_MYC_PATHWAY C-MYC pathway
0.0 0.7 PID_ATR_PATHWAY ATR signaling pathway
0.0 0.4 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.0 0.9 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 0.3 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.6 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.0 0.7 PID_RB_1PATHWAY Regulation of retinoblastoma protein

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 8.9 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.4 10.2 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.2 5.6 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.2 4.1 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 5.5 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 5.3 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.1 3.9 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 2.5 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.1 5.9 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 1.5 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 1.5 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.1 3.8 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 2.0 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.1 2.0 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 2.8 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 1.7 REACTOME_KINESINS Genes involved in Kinesins
0.1 1.8 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 0.8 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 6.8 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 3.1 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.7 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.7 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 0.7 REACTOME_SIGNALING_BY_PDGF Genes involved in Signaling by PDGF
0.0 0.6 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.2 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 1.1 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.0 0.5 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.9 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.5 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.3 REACTOME_ACTIVATION_OF_NF_KAPPAB_IN_B_CELLS Genes involved in Activation of NF-kappaB in B Cells
0.0 1.6 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.7 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.4 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 1.8 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.0 0.9 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.3 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.0 1.5 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.0 0.2 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.5 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.4 REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0 0.1 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation