Motif ID: Gsx2_Hoxd3_Vax1

Z-value: 0.728

Transcription factors associated with Gsx2_Hoxd3_Vax1:

Gene SymbolEntrez IDGene Name
Gsx2 ENSMUSG00000035946.6 Gsx2
Hoxd3 ENSMUSG00000079277.3 Hoxd3
Vax1 ENSMUSG00000006270.6 Vax1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gsx2mm10_v2_chr5_+_75075464_750756010.811.9e-10Click!
Vax1mm10_v2_chr19_-_59170978_591709780.795.6e-10Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Gsx2_Hoxd3_Vax1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_8710734 13.904 ENSMUST00000005493.7
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr15_-_8710409 12.276 ENSMUST00000157065.1
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr8_+_94152607 5.916 ENSMUST00000034211.8
Mt3
metallothionein 3
chr15_+_25773985 4.925 ENSMUST00000125667.1
Myo10
myosin X
chr4_-_14621805 4.580 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chr2_+_91457501 3.703 ENSMUST00000028689.3
Lrp4
low density lipoprotein receptor-related protein 4
chr9_-_90255927 3.106 ENSMUST00000144646.1
Tbc1d2b
TBC1 domain family, member 2B
chr3_+_66219909 3.061 ENSMUST00000029421.5
Ptx3
pentraxin related gene
chr4_-_14621494 3.058 ENSMUST00000149633.1
Slc26a7
solute carrier family 26, member 7
chr4_-_14621669 2.910 ENSMUST00000143105.1
Slc26a7
solute carrier family 26, member 7
chr2_+_116067213 2.610 ENSMUST00000152412.1
G630016G05Rik
RIKEN cDNA G630016G05 gene
chr18_+_57142782 2.547 ENSMUST00000139892.1
Megf10
multiple EGF-like-domains 10
chr18_+_56432116 2.389 ENSMUST00000070166.5
Gramd3
GRAM domain containing 3
chr15_+_98571004 2.270 ENSMUST00000023728.6
4930415O20Rik
RIKEN cDNA 4930415O20 gene
chr3_+_159839729 2.183 ENSMUST00000068952.5
Wls
wntless homolog (Drosophila)
chr2_+_109917639 2.060 ENSMUST00000046548.7
ENSMUST00000111037.2
Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr2_-_168767136 2.037 ENSMUST00000029061.5
ENSMUST00000103074.1
Sall4

sal-like 4 (Drosophila)

chr9_+_119063429 1.926 ENSMUST00000141185.1
ENSMUST00000126251.1
ENSMUST00000136561.1
Vill


villin-like


chr2_+_20737306 1.881 ENSMUST00000114606.1
ENSMUST00000114608.1
Etl4

enhancer trap locus 4

chr4_+_8690399 1.860 ENSMUST00000127476.1
Chd7
chromodomain helicase DNA binding protein 7
chr14_-_48662740 1.844 ENSMUST00000122009.1
Otx2
orthodenticle homolog 2 (Drosophila)
chr2_-_168767029 1.816 ENSMUST00000075044.3
Sall4
sal-like 4 (Drosophila)
chr2_+_91257323 1.526 ENSMUST00000111349.2
ENSMUST00000131711.1
Pacsin3

protein kinase C and casein kinase substrate in neurons 3

chr6_-_34317442 1.492 ENSMUST00000154655.1
ENSMUST00000102980.4
Akr1b3

aldo-keto reductase family 1, member B3 (aldose reductase)

chr12_-_55014329 1.351 ENSMUST00000172875.1
Baz1a
bromodomain adjacent to zinc finger domain 1A
chr2_+_71389239 1.267 ENSMUST00000028408.2
Hat1
histone aminotransferase 1
chr10_-_8886033 1.244 ENSMUST00000015449.5
Sash1
SAM and SH3 domain containing 1
chr17_-_70853482 1.188 ENSMUST00000118283.1
Tgif1
TGFB-induced factor homeobox 1
chrX_+_9885622 1.188 ENSMUST00000067529.2
ENSMUST00000086165.3
Sytl5

synaptotagmin-like 5

chr15_-_37459327 1.164 ENSMUST00000119730.1
ENSMUST00000120746.1
Ncald

neurocalcin delta

chr19_+_55895508 1.141 ENSMUST00000111646.1
Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr2_-_116067391 1.107 ENSMUST00000140185.1
2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr14_+_26259109 1.034 ENSMUST00000174494.1
Duxbl3
double homeobox B-like 3
chr15_+_39006272 1.011 ENSMUST00000179165.1
ENSMUST00000022906.7
Fzd6

frizzled homolog 6 (Drosophila)

chr13_-_102906046 0.972 ENSMUST00000171791.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr11_+_59306920 0.940 ENSMUST00000000128.3
ENSMUST00000108783.3
Wnt9a

wingless-type MMTV integration site 9A

chr13_+_51408618 0.940 ENSMUST00000087978.3
S1pr3
sphingosine-1-phosphate receptor 3
chr13_-_102905740 0.889 ENSMUST00000167462.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr2_+_106693185 0.806 ENSMUST00000111063.1
Mpped2
metallophosphoesterase domain containing 2
chr8_-_106573461 0.785 ENSMUST00000073722.5
Gm10073
predicted pseudogene 10073
chr3_+_103739366 0.740 ENSMUST00000106852.1
Gm10964
predicted gene 10964
chr6_+_8948608 0.729 ENSMUST00000160300.1
Nxph1
neurexophilin 1
chr14_+_79515618 0.713 ENSMUST00000110835.1
Elf1
E74-like factor 1
chr1_+_161070767 0.691 ENSMUST00000111618.1
ENSMUST00000111620.3
ENSMUST00000028035.7
Cenpl


centromere protein L


chr3_-_116253467 0.682 ENSMUST00000090473.5
Gpr88
G-protein coupled receptor 88
chr2_-_91649785 0.680 ENSMUST00000111333.1
Zfp408
zinc finger protein 408
chr12_+_38780284 0.659 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
Etv1


ets variant gene 1


chr14_+_26119811 0.650 ENSMUST00000173617.1
Duxbl2
doubl homeobox B-like 2
chr3_+_53488677 0.639 ENSMUST00000029307.3
Stoml3
stomatin (Epb7.2)-like 3
chr12_-_79296266 0.633 ENSMUST00000021547.6
Zfyve26
zinc finger, FYVE domain containing 26
chr11_-_109611417 0.629 ENSMUST00000103060.3
ENSMUST00000047186.3
ENSMUST00000106689.1
Wipi1


WD repeat domain, phosphoinositide interacting 1


chr2_-_91649751 0.608 ENSMUST00000099714.3
Zfp408
zinc finger protein 408
chrX_+_106920618 0.581 ENSMUST00000060576.7
Lpar4
lysophosphatidic acid receptor 4
chr1_-_152625212 0.562 ENSMUST00000027760.7
Rgl1
ral guanine nucleotide dissociation stimulator,-like 1
chr12_+_38781093 0.561 ENSMUST00000161513.1
Etv1
ets variant gene 1
chr4_-_42661893 0.542 ENSMUST00000108006.3
Il11ra2
interleukin 11 receptor, alpha chain 2
chrM_-_14060 0.535 ENSMUST00000082419.1
mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr11_+_60537978 0.534 ENSMUST00000044250.3
Alkbh5
alkB, alkylation repair homolog 5 (E. coli)
chr14_+_25980039 0.526 ENSMUST00000173155.1
Duxbl1
double homeobox B-like 1
chr7_+_101896340 0.525 ENSMUST00000035395.7
ENSMUST00000106973.1
ENSMUST00000144207.1
Anapc15


anaphase prompoting complex C subunit 15


chr2_-_29787622 0.517 ENSMUST00000177467.1
ENSMUST00000113807.3
Trub2

TruB pseudouridine (psi) synthase homolog 2 (E. coli)

chr13_-_53473074 0.500 ENSMUST00000021922.8
Msx2
msh homeobox 2
chr9_-_39603635 0.497 ENSMUST00000119722.1
AW551984
expressed sequence AW551984
chr6_-_54566484 0.467 ENSMUST00000019268.4
Scrn1
secernin 1
chr14_+_47298260 0.446 ENSMUST00000166743.1
Mapk1ip1l
mitogen-activated protein kinase 1 interacting protein 1-like
chr9_+_121950988 0.442 ENSMUST00000043011.7
Fam198a
family with sequence similarity 198, member A
chrX_+_107255878 0.435 ENSMUST00000101294.2
ENSMUST00000118820.1
ENSMUST00000120971.1
Gpr174


G protein-coupled receptor 174


chr8_+_36489191 0.421 ENSMUST00000171777.1
6430573F11Rik
RIKEN cDNA 6430573F11 gene
chr1_-_172027269 0.419 ENSMUST00000027837.6
ENSMUST00000111264.1
Vangl2

vang-like 2 (van gogh, Drosophila)

chr10_-_83648631 0.392 ENSMUST00000146876.2
ENSMUST00000176294.1
Appl2

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2

chr5_-_63968867 0.392 ENSMUST00000154169.1
Rell1
RELT-like 1
chr5_+_48242549 0.391 ENSMUST00000172493.1
Slit2
slit homolog 2 (Drosophila)
chr5_-_149051300 0.380 ENSMUST00000110505.1
Hmgb1
high mobility group box 1
chr5_+_136987019 0.321 ENSMUST00000004968.4
Plod3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr3_+_19187321 0.320 ENSMUST00000130806.1
ENSMUST00000117529.1
ENSMUST00000119865.1
Mtfr1


mitochondrial fission regulator 1


chr7_+_19368498 0.310 ENSMUST00000132655.1
Ppp1r13l
protein phosphatase 1, regulatory (inhibitor) subunit 13 like
chr12_+_111814170 0.308 ENSMUST00000021714.7
Zfyve21
zinc finger, FYVE domain containing 21
chr5_-_138187177 0.295 ENSMUST00000110937.1
ENSMUST00000139276.1
ENSMUST00000048698.7
ENSMUST00000123415.1
Taf6



TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor



chr12_+_38780817 0.275 ENSMUST00000160856.1
Etv1
ets variant gene 1
chrX_-_101086020 0.266 ENSMUST00000113710.1
Slc7a3
solute carrier family 7 (cationic amino acid transporter, y+ system), member 3
chr10_-_33995054 0.258 ENSMUST00000164429.1
Gm17567
predicted gene, 17567
chr12_-_98577940 0.247 ENSMUST00000110113.1
Kcnk10
potassium channel, subfamily K, member 10
chr16_-_50330987 0.244 ENSMUST00000114488.1
Bbx
bobby sox homolog (Drosophila)
chr4_+_105789869 0.240 ENSMUST00000184254.1
Gm12728
predicted gene 12728
chrX_-_160138375 0.229 ENSMUST00000033662.8
Pdha1
pyruvate dehydrogenase E1 alpha 1
chr11_+_114851507 0.219 ENSMUST00000177952.1
Gprc5c
G protein-coupled receptor, family C, group 5, member C
chr2_-_120154600 0.204 ENSMUST00000028755.7
Ehd4
EH-domain containing 4
chr4_+_154964117 0.201 ENSMUST00000030931.4
ENSMUST00000070953.4
Pank4

pantothenate kinase 4

chr10_-_76110956 0.197 ENSMUST00000120757.1
Slc5a4b
solute carrier family 5 (neutral amino acid transporters, system A), member 4b
chr3_-_59220150 0.195 ENSMUST00000170388.1
P2ry12
purinergic receptor P2Y, G-protein coupled 12
chrX_+_169685191 0.194 ENSMUST00000112104.1
ENSMUST00000112107.1
Mid1

midline 1

chr8_-_112011266 0.191 ENSMUST00000164470.1
ENSMUST00000093120.5
Kars

lysyl-tRNA synthetase

chr14_+_48446128 0.186 ENSMUST00000124720.1
Tmem260
transmembrane protein 260
chr2_-_164389095 0.181 ENSMUST00000167427.1
Slpi
secretory leukocyte peptidase inhibitor
chr6_+_47920476 0.175 ENSMUST00000009411.8
Zfp212
Zinc finger protein 212
chr9_+_94669876 0.170 ENSMUST00000033463.9
Slc9a9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr8_-_112011320 0.168 ENSMUST00000034426.6
Kars
lysyl-tRNA synthetase
chr2_+_110597298 0.159 ENSMUST00000045972.6
ENSMUST00000111026.2
Slc5a12

solute carrier family 5 (sodium/glucose cotransporter), member 12

chr4_+_103143052 0.150 ENSMUST00000106855.1
Mier1
mesoderm induction early response 1 homolog (Xenopus laevis
chr2_+_19371636 0.147 ENSMUST00000023856.8
Msrb2
methionine sulfoxide reductase B2
chr14_-_64455903 0.142 ENSMUST00000067927.7
Msra
methionine sulfoxide reductase A
chr12_-_84617326 0.135 ENSMUST00000021666.4
Abcd4
ATP-binding cassette, sub-family D (ALD), member 4
chr1_-_161070613 0.130 ENSMUST00000035430.3
Dars2
aspartyl-tRNA synthetase 2 (mitochondrial)
chr9_-_13818665 0.117 ENSMUST00000150893.1
ENSMUST00000124883.1
Cep57

centrosomal protein 57

chr5_-_3647806 0.111 ENSMUST00000119783.1
ENSMUST00000007559.8
Gatad1

GATA zinc finger domain containing 1

chr5_+_138187485 0.105 ENSMUST00000110934.2
Cnpy4
canopy 4 homolog (zebrafish)
chr2_-_28916412 0.101 ENSMUST00000050776.2
ENSMUST00000113849.1
Barhl1

BarH-like 1 (Drosophila)

chr4_-_117682233 0.092 ENSMUST00000102687.3
Dmap1
DNA methyltransferase 1-associated protein 1
chr10_+_128337761 0.090 ENSMUST00000005826.7
Cs
citrate synthase
chr1_+_93421682 0.088 ENSMUST00000096427.4
Gm17415
predicted gene, 17415
chr11_+_58171648 0.088 ENSMUST00000020820.1
Mrpl22
mitochondrial ribosomal protein L22
chr9_+_37208291 0.085 ENSMUST00000034632.8
Tmem218
transmembrane protein 218
chr1_-_163725123 0.073 ENSMUST00000159679.1
Mettl11b
methyltransferase like 11B
chr19_-_32196393 0.062 ENSMUST00000151822.1
Sgms1
sphingomyelin synthase 1
chr2_+_69897255 0.056 ENSMUST00000131553.1
Ubr3
ubiquitin protein ligase E3 component n-recognin 3
chr10_+_128083273 0.048 ENSMUST00000026459.5
Atp5b
ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit
chr4_-_129227883 0.048 ENSMUST00000106051.1
C77080
expressed sequence C77080
chr5_-_137072254 0.047 ENSMUST00000077523.3
ENSMUST00000041388.4
Serpine1

serine (or cysteine) peptidase inhibitor, clade E, member 1

chr5_-_100416115 0.045 ENSMUST00000182886.1
ENSMUST00000094578.4
Sec31a

Sec31 homolog A (S. cerevisiae)

chr3_+_88297147 0.035 ENSMUST00000164166.1
ENSMUST00000168062.1
Cct3

chaperonin containing Tcp1, subunit 3 (gamma)

chr12_+_102128718 0.034 ENSMUST00000159329.1
Slc24a4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr5_+_66968559 0.033 ENSMUST00000127184.1
Limch1
LIM and calponin homology domains 1
chr7_+_101896817 0.031 ENSMUST00000143835.1
Anapc15
anaphase prompoting complex C subunit 15
chr14_-_52104015 0.031 ENSMUST00000111610.4
ENSMUST00000164655.1
Hnrnpc

heterogeneous nuclear ribonucleoprotein C

chrX_-_157415286 0.030 ENSMUST00000079945.4
ENSMUST00000138396.1
Phex

phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)

chr2_+_120476911 0.026 ENSMUST00000110716.1
ENSMUST00000028748.6
ENSMUST00000090028.5
ENSMUST00000110719.2
Capn3



calpain 3



chr12_-_80643799 0.023 ENSMUST00000166931.1
Erh
enhancer of rudimentary homolog (Drosophila)
chr4_+_62525369 0.005 ENSMUST00000062145.1
4933430I17Rik
RIKEN cDNA 4933430I17 gene
chr3_+_88297115 0.003 ENSMUST00000001452.7
Cct3
chaperonin containing Tcp1, subunit 3 (gamma)

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
6.5 26.2 GO:0043490 malate-aspartate shuttle(GO:0043490)
2.0 5.9 GO:0097212 lysosomal membrane organization(GO:0097212)
1.5 10.5 GO:0019532 oxalate transport(GO:0019532)
1.2 3.7 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.7 2.2 GO:0061357 Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) positive regulation of Wnt protein secretion(GO:0061357)
0.7 2.1 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.6 1.9 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.6 3.1 GO:0052428 modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
0.5 1.5 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.5 1.5 GO:0006059 hexitol metabolic process(GO:0006059) alditol biosynthetic process(GO:0019401)
0.5 1.8 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.4 2.6 GO:0014719 skeletal muscle satellite cell activation(GO:0014719)
0.4 1.2 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.2 3.8 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.2 0.7 GO:0061743 motor learning(GO:0061743)
0.1 1.1 GO:0048625 myoblast fate commitment(GO:0048625)
0.1 1.3 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.1 0.4 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.1 1.5 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 0.5 GO:0035553 oxidative single-stranded RNA demethylation(GO:0035553)
0.1 0.4 GO:0021972 corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260)
0.1 0.4 GO:0045819 plasmacytoid dendritic cell activation(GO:0002270) positive regulation of glycogen catabolic process(GO:0045819)
0.1 0.4 GO:0045575 basophil activation involved in immune response(GO:0002276) basophil activation(GO:0045575)
0.1 0.5 GO:0060923 cardiac muscle cell fate commitment(GO:0060923)
0.1 0.3 GO:0046947 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.1 0.9 GO:0045602 negative regulation of endothelial cell differentiation(GO:0045602)
0.1 1.2 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 4.9 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.1 0.2 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.1 1.5 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 0.3 GO:0015822 ornithine transport(GO:0015822)
0.0 0.6 GO:0048199 protein localization to pre-autophagosomal structure(GO:0034497) vesicle targeting, to, from or within Golgi(GO:0048199)
0.0 1.2 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.9 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.0 1.6 GO:0051693 actin filament capping(GO:0051693)
0.0 3.1 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 0.2 GO:1904659 glucose transmembrane transport(GO:1904659)
0.0 0.4 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.0 0.6 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.1 GO:0030091 protein repair(GO:0030091)
0.0 0.1 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.0 0.6 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.0 0.2 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.1 GO:0009235 cobalamin metabolic process(GO:0009235)
0.0 0.5 GO:0001522 pseudouridine synthesis(GO:0001522)
0.0 0.3 GO:0003215 cardiac right ventricle morphogenesis(GO:0003215)
0.0 0.2 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.1 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0 0.2 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.0 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.0 0.0 GO:2000097 arachidonic acid metabolite production involved in inflammatory response(GO:0002538) regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.0 1.2 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.0 1.9 GO:0048706 embryonic skeletal system development(GO:0048706)
0.0 0.2 GO:0031937 positive regulation of chromatin silencing(GO:0031937)
0.0 0.2 GO:0015937 coenzyme A biosynthetic process(GO:0015937)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.5 GO:0097454 Schwann cell microvillus(GO:0097454)
0.3 1.4 GO:0008623 CHRAC(GO:0008623)
0.3 3.7 GO:0016600 flotillin complex(GO:0016600)
0.2 1.1 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 36.6 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 2.5 GO:0001891 phagocytic cup(GO:0001891)
0.1 4.9 GO:0016459 myosin complex(GO:0016459)
0.1 1.0 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 2.2 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.6 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 2.6 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 6.1 GO:0070382 exocytic vesicle(GO:0070382)
0.0 3.5 GO:0000792 heterochromatin(GO:0000792)
0.0 0.4 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.4 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 0.6 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.1 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.3 GO:0033276 transcription factor TFTC complex(GO:0033276)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.4 26.2 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
1.0 10.5 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.8 5.6 GO:0001849 complement component C1q binding(GO:0001849)
0.3 1.5 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.2 2.2 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.2 4.7 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.2 2.1 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 0.5 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.1 0.4 GO:0000402 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)
0.1 2.0 GO:0045125 bioactive lipid receptor activity(GO:0045125)
0.1 1.5 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.1 0.6 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 4.9 GO:0030507 spectrin binding(GO:0030507)
0.1 0.3 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.1 1.3 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.1 0.4 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.1 0.3 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.1 1.1 GO:0070016 gamma-catenin binding(GO:0045295) armadillo repeat domain binding(GO:0070016)
0.1 1.2 GO:0070410 co-SMAD binding(GO:0070410)
0.1 1.9 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.4 GO:0048495 GTPase inhibitor activity(GO:0005095) Roundabout binding(GO:0048495)
0.0 0.1 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0 1.2 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.2 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.1 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0 1.2 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 0.5 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.5 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.3 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 1.3 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.1 GO:0034604 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.0 0.2 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.9 GO:0005109 frizzled binding(GO:0005109)
0.0 1.2 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.2 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.2 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.2 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.1 GO:0005118 sevenless binding(GO:0005118)
0.0 0.4 GO:0070566 adenylyltransferase activity(GO:0070566)
0.0 0.1 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 1.9 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 2.2 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.2 GO:0005355 glucose transmembrane transporter activity(GO:0005355)
0.0 0.1 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.9 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 3.1 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 2.9 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.1 1.5 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.9 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 5.0 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.6 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.4 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 0.7 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 3.4 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 0.4 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 1.2 PID_AR_PATHWAY Coregulation of Androgen receptor activity

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 23.9 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.2 10.8 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 5.3 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 0.8 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.1 1.2 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.2 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 1.2 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.4 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 0.5 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 1.7 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.2 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.7 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.1 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex