Motif ID: Hes1

Z-value: 1.529


Transcription factors associated with Hes1:

Gene SymbolEntrez IDGene Name
Hes1 ENSMUSG00000022528.7 Hes1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hes1mm10_v2_chr16_+_30065333_300653510.612.6e-05Click!


Activity profile for motif Hes1.

activity profile for motif Hes1


Sorted Z-values histogram for motif Hes1

Sorted Z-values for motif Hes1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hes1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_12026237 31.184 ENSMUST00000150972.1
Grb10
growth factor receptor bound protein 10
chr11_-_12026732 28.431 ENSMUST00000143915.1
Grb10
growth factor receptor bound protein 10
chr11_-_89302545 13.208 ENSMUST00000061728.3
Nog
noggin
chr14_-_79301623 12.354 ENSMUST00000022595.7
Rgcc
regulator of cell cycle
chr17_-_25797032 11.333 ENSMUST00000165838.1
ENSMUST00000002344.6
Metrn

meteorin, glial cell differentiation regulator

chr4_+_154960915 10.180 ENSMUST00000049621.6
Hes5
hairy and enhancer of split 5 (Drosophila)
chr1_+_153652943 7.389 ENSMUST00000041776.5
Rgs8
regulator of G-protein signaling 8
chr4_+_65124174 7.356 ENSMUST00000084501.3
Pappa
pregnancy-associated plasma protein A
chr19_+_60144682 6.861 ENSMUST00000065383.4
E330013P04Rik
RIKEN cDNA E330013P04 gene
chr4_-_58553553 6.610 ENSMUST00000107575.2
ENSMUST00000107574.1
ENSMUST00000147354.1
Lpar1


lysophosphatidic acid receptor 1


chrX_-_52165252 6.299 ENSMUST00000033450.2
Gpc4
glypican 4
chr4_-_58553311 5.525 ENSMUST00000107571.1
ENSMUST00000055018.4
Lpar1

lysophosphatidic acid receptor 1

chr1_-_175692624 5.402 ENSMUST00000027809.7
Opn3
opsin 3
chr6_-_90716489 5.312 ENSMUST00000101153.3
Iqsec1
IQ motif and Sec7 domain 1
chr10_-_30842765 5.267 ENSMUST00000019924.8
Hey2
hairy/enhancer-of-split related with YRPW motif 2
chr5_+_93093428 5.063 ENSMUST00000074733.7
Sept11
septin 11
chr12_+_110279228 5.022 ENSMUST00000097228.4
Dio3
deiodinase, iodothyronine type III
chr4_-_41695442 4.817 ENSMUST00000102961.3
ENSMUST00000064443.6
Cntfr

ciliary neurotrophic factor receptor

chr4_-_41695935 4.814 ENSMUST00000145379.1
Cntfr
ciliary neurotrophic factor receptor
chr1_-_166309585 4.452 ENSMUST00000168347.1
5330438I03Rik
RIKEN cDNA 5330438I03 gene
chr4_+_116877376 4.344 ENSMUST00000044823.3
Zswim5
zinc finger SWIM-type containing 5
chr19_-_24555819 4.342 ENSMUST00000112673.2
ENSMUST00000025800.8
Pip5k1b

phosphatidylinositol-4-phosphate 5-kinase, type 1 beta

chr6_+_17306335 4.334 ENSMUST00000007799.6
ENSMUST00000115456.1
ENSMUST00000115455.2
ENSMUST00000130505.1
Cav1



caveolin 1, caveolae protein



chr18_+_82910863 4.292 ENSMUST00000171238.1
Zfp516
zinc finger protein 516
chr11_+_72042455 4.183 ENSMUST00000021164.3
Fam64a
family with sequence similarity 64, member A
chr8_+_71406003 4.105 ENSMUST00000119976.1
ENSMUST00000120725.1
Ankle1

ankyrin repeat and LEM domain containing 1

chr2_-_172043466 3.954 ENSMUST00000087950.3
Cbln4
cerebellin 4 precursor protein
chr8_+_119446719 3.860 ENSMUST00000098363.3
Necab2
N-terminal EF-hand calcium binding protein 2
chr11_-_102925086 3.829 ENSMUST00000021311.9
Kif18b
kinesin family member 18B
chr7_+_79660196 3.765 ENSMUST00000035977.7
Ticrr
TOPBP1-interacting checkpoint and replication regulator
chr1_+_132316112 3.657 ENSMUST00000082125.5
ENSMUST00000072177.7
Nuak2

NUAK family, SNF1-like kinase, 2

chr11_-_60811228 3.646 ENSMUST00000018744.8
Shmt1
serine hydroxymethyltransferase 1 (soluble)
chr7_-_140049083 3.611 ENSMUST00000055353.7
Msx3
msh homeobox 3
chr6_+_124829540 3.604 ENSMUST00000150120.1
Cdca3
cell division cycle associated 3
chr4_-_141874879 3.583 ENSMUST00000036854.3
Efhd2
EF hand domain containing 2
chr17_+_87282880 3.528 ENSMUST00000041110.5
ENSMUST00000125875.1
Ttc7

tetratricopeptide repeat domain 7

chr11_-_116828000 3.520 ENSMUST00000047715.5
ENSMUST00000021170.2
Mxra7

matrix-remodelling associated 7

chr13_-_23551648 3.457 ENSMUST00000102971.1
Hist1h4f
histone cluster 1, H4f
chr4_-_41713491 3.406 ENSMUST00000038434.3
Rpp25l
ribonuclease P/MRP 25 subunit-like
chr3_+_127633134 3.382 ENSMUST00000029587.7
Neurog2
neurogenin 2
chr17_-_87282793 3.350 ENSMUST00000146560.2
4833418N02Rik
RIKEN cDNA 4833418N02 gene
chr4_-_58553184 3.336 ENSMUST00000145361.1
Lpar1
lysophosphatidic acid receptor 1
chr2_+_156840966 3.318 ENSMUST00000109564.1
Tgif2
TGFB-induced factor homeobox 2
chr10_+_26078255 3.290 ENSMUST00000041011.3
Gm9767
predicted gene 9767
chr6_+_120666388 3.250 ENSMUST00000112686.1
Cecr2
cat eye syndrome chromosome region, candidate 2
chr14_+_46882854 3.205 ENSMUST00000022386.8
ENSMUST00000100672.3
Samd4

sterile alpha motif domain containing 4

chr1_-_84696182 3.182 ENSMUST00000049126.6
Dner
delta/notch-like EGF-related receptor
chr11_-_59787636 3.146 ENSMUST00000125307.1
Pld6
phospholipase D family, member 6
chr9_-_48835932 3.119 ENSMUST00000093852.3
Zbtb16
zinc finger and BTB domain containing 16
chr8_-_87959560 3.090 ENSMUST00000109655.2
Zfp423
zinc finger protein 423
chr1_-_189688074 3.041 ENSMUST00000171929.1
ENSMUST00000165962.1
Cenpf

centromere protein F

chr1_+_95313607 2.998 ENSMUST00000059975.6
Fam174a
family with sequence similarity 174, member A
chr13_-_56296551 2.948 ENSMUST00000021970.9
Cxcl14
chemokine (C-X-C motif) ligand 14
chr18_-_53418004 2.920 ENSMUST00000025419.7
Ppic
peptidylprolyl isomerase C
chr9_-_103365769 2.893 ENSMUST00000035484.4
ENSMUST00000072249.6
Cdv3

carnitine deficiency-associated gene expressed in ventricle 3

chr2_+_72476225 2.868 ENSMUST00000157019.1
Cdca7
cell division cycle associated 7
chr15_-_38300693 2.863 ENSMUST00000074043.5
Klf10
Kruppel-like factor 10
chr12_-_17176888 2.838 ENSMUST00000170580.1
Kcnf1
potassium voltage-gated channel, subfamily F, member 1
chrX_-_141725181 2.799 ENSMUST00000067841.7
Irs4
insulin receptor substrate 4
chr17_-_87282771 2.792 ENSMUST00000161759.1
4833418N02Rik
RIKEN cDNA 4833418N02 gene
chr7_+_45017953 2.773 ENSMUST00000044111.7
Rras
Harvey rat sarcoma oncogene, subgroup R
chr12_-_50649190 2.745 ENSMUST00000002765.7
Prkd1
protein kinase D1
chrX_-_73930751 2.735 ENSMUST00000155597.1
ENSMUST00000114379.1
Renbp

renin binding protein

chr2_+_72476159 2.730 ENSMUST00000102691.4
Cdca7
cell division cycle associated 7
chr3_+_37639945 2.638 ENSMUST00000108109.1
ENSMUST00000038569.1
Spry1

sprouty homolog 1 (Drosophila)

chr6_-_38299236 2.597 ENSMUST00000058524.2
Zc3hav1l
zinc finger CCCH-type, antiviral 1-like
chr5_-_52566264 2.585 ENSMUST00000039750.5
Lgi2
leucine-rich repeat LGI family, member 2
chr7_+_137437591 2.528 ENSMUST00000064404.6
Glrx3
glutaredoxin 3
chr5_+_73006897 2.527 ENSMUST00000031127.7
Slc10a4
solute carrier family 10 (sodium/bile acid cotransporter family), member 4
chr4_-_55532453 2.513 ENSMUST00000132746.1
ENSMUST00000107619.2
Klf4

Kruppel-like factor 4 (gut)

chr1_-_118982551 2.488 ENSMUST00000159678.1
Gli2
GLI-Kruppel family member GLI2
chr7_-_118856254 2.480 ENSMUST00000033277.7
Knop1
lysine rich nucleolar protein 1
chr12_+_116077720 2.463 ENSMUST00000011315.3
Vipr2
vasoactive intestinal peptide receptor 2
chr5_+_30105161 2.444 ENSMUST00000058045.4
Gareml
GRB2 associated, regulator of MAPK1-like
chr11_-_69921329 2.400 ENSMUST00000108613.3
ENSMUST00000043419.3
ENSMUST00000070996.4
Eif5a


eukaryotic translation initiation factor 5A


chr7_+_19083842 2.383 ENSMUST00000032568.7
ENSMUST00000122999.1
ENSMUST00000108473.3
ENSMUST00000108474.1
Dmpk



dystrophia myotonica-protein kinase



chrX_-_155338460 2.363 ENSMUST00000026328.4
Prdx4
peroxiredoxin 4
chr1_-_131097535 2.309 ENSMUST00000016672.4
Mapkapk2
MAP kinase-activated protein kinase 2
chr10_-_127534540 2.287 ENSMUST00000095266.2
Nxph4
neurexophilin 4
chr16_-_16146771 2.273 ENSMUST00000040248.7
Spidr
scaffolding protein involved i DNA repair
chr4_+_130360132 2.250 ENSMUST00000105994.3
Snrnp40
small nuclear ribonucleoprotein 40 (U5)
chr7_-_126799163 2.204 ENSMUST00000032934.5
Aldoa
aldolase A, fructose-bisphosphate
chr2_+_180171485 2.198 ENSMUST00000061437.4
Adrm1
adhesion regulating molecule 1
chr4_+_128654686 2.101 ENSMUST00000030588.6
ENSMUST00000136377.1
Phc2

polyhomeotic-like 2 (Drosophila)

chr7_+_128523576 2.093 ENSMUST00000033136.7
Bag3
BCL2-associated athanogene 3
chr7_-_126799134 2.085 ENSMUST00000087566.4
Aldoa
aldolase A, fructose-bisphosphate
chr2_+_30286383 2.057 ENSMUST00000064447.5
Nup188
nucleoporin 188
chr13_-_81710937 2.035 ENSMUST00000161920.1
ENSMUST00000048993.5
Polr3g

polymerase (RNA) III (DNA directed) polypeptide G

chr16_-_97922582 2.021 ENSMUST00000170757.1
C2cd2
C2 calcium-dependent domain containing 2
chr2_-_84727350 1.983 ENSMUST00000028475.8
Clp1
CLP1, cleavage and polyadenylation factor I subunit
chr6_+_17306415 1.981 ENSMUST00000150901.1
Cav1
caveolin 1, caveolae protein
chr8_+_75033673 1.953 ENSMUST00000078847.5
ENSMUST00000165630.1
Tom1

target of myb1 homolog (chicken)

chr4_+_32983008 1.919 ENSMUST00000098190.3
ENSMUST00000029946.7
Rragd

Ras-related GTP binding D

chr17_+_35861343 1.913 ENSMUST00000172931.1
Nrm
nurim (nuclear envelope membrane protein)
chr5_+_34336928 1.881 ENSMUST00000182047.1
Rnf4
ring finger protein 4
chr15_+_84923383 1.875 ENSMUST00000165443.2
Nup50
nucleoporin 50
chr2_+_34772089 1.844 ENSMUST00000028222.6
ENSMUST00000100171.2
Hspa5

heat shock protein 5

chr15_-_73184840 1.809 ENSMUST00000044113.10
Ago2
argonaute RISC catalytic subunit 2
chr3_-_90052463 1.790 ENSMUST00000029553.9
ENSMUST00000064639.8
ENSMUST00000090908.6
Ubap2l


ubiquitin associated protein 2-like


chr4_-_108848619 1.777 ENSMUST00000164855.1
A730015C16Rik
RIKEN cDNA A730015C16 gene
chr12_-_111485808 1.755 ENSMUST00000010673.5
Gm266
predicted gene 266
chr11_-_21371143 1.739 ENSMUST00000060895.5
Ugp2
UDP-glucose pyrophosphorylase 2
chr18_+_70568189 1.657 ENSMUST00000074058.4
ENSMUST00000114946.3
Mbd2

methyl-CpG binding domain protein 2

chr9_+_62342449 1.613 ENSMUST00000156461.1
Anp32a
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
chr11_-_88718165 1.597 ENSMUST00000107908.1
Msi2
musashi RNA-binding protein 2
chr9_+_106429537 1.579 ENSMUST00000059802.6
Rpl29
ribosomal protein L29
chr13_-_29984219 1.565 ENSMUST00000146092.1
E2f3
E2F transcription factor 3
chr17_+_20570362 1.549 ENSMUST00000095633.3
Gm5145
predicted pseudogene 5145
chr10_+_128790903 1.544 ENSMUST00000026411.6
Mmp19
matrix metallopeptidase 19
chr1_-_93445642 1.542 ENSMUST00000042498.7
Hdlbp
high density lipoprotein (HDL) binding protein
chr11_-_88955366 1.497 ENSMUST00000000287.8
Scpep1
serine carboxypeptidase 1
chr12_+_108792946 1.488 ENSMUST00000021692.7
Yy1
YY1 transcription factor
chr14_-_30626196 1.474 ENSMUST00000112210.3
ENSMUST00000112211.2
ENSMUST00000112208.1
Prkcd


protein kinase C, delta


chrX_+_71555918 1.460 ENSMUST00000072699.6
ENSMUST00000114582.2
ENSMUST00000015361.4
ENSMUST00000088874.3
Hmgb3



high mobility group box 3



chr8_-_124949165 1.459 ENSMUST00000034469.5
Egln1
EGL nine homolog 1 (C. elegans)
chr4_-_43562397 1.455 ENSMUST00000030187.7
Tln1
talin 1
chr16_-_57167307 1.445 ENSMUST00000023432.8
Nit2
nitrilase family, member 2
chr11_+_54866374 1.442 ENSMUST00000020504.5
Hint1
histidine triad nucleotide binding protein 1
chr4_+_115737754 1.437 ENSMUST00000106522.2
Efcab14
EF-hand calcium binding domain 14
chr5_+_143403819 1.420 ENSMUST00000110731.2
Kdelr2
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
chr12_+_85599388 1.397 ENSMUST00000050687.6
Jdp2
Jun dimerization protein 2
chr16_+_10835046 1.395 ENSMUST00000037913.8
Rmi2
RMI2, RecQ mediated genome instability 2, homolog (S. cerevisiae)
chr11_+_99041237 1.375 ENSMUST00000017637.6
Igfbp4
insulin-like growth factor binding protein 4
chr2_-_84727236 1.365 ENSMUST00000165219.1
Clp1
CLP1, cleavage and polyadenylation factor I subunit
chr11_-_66525964 1.343 ENSMUST00000066679.6
Shisa6
shisa homolog 6 (Xenopus laevis)
chr9_-_75409951 1.338 ENSMUST00000049355.10
Mapk6
mitogen-activated protein kinase 6
chr2_-_25546872 1.337 ENSMUST00000114234.1
ENSMUST00000028311.6
Traf2

TNF receptor-associated factor 2

chr6_+_48593883 1.331 ENSMUST00000154010.1
ENSMUST00000163452.1
ENSMUST00000118229.1
ENSMUST00000009420.8
Repin1



replication initiator 1



chr1_-_93478785 1.298 ENSMUST00000170883.1
Hdlbp
high density lipoprotein (HDL) binding protein
chr16_-_33967032 1.279 ENSMUST00000023510.6
Umps
uridine monophosphate synthetase
chr7_-_45459839 1.279 ENSMUST00000094434.4
Ftl1
ferritin light chain 1
chr4_+_115737738 1.277 ENSMUST00000106525.2
Efcab14
EF-hand calcium binding domain 14
chr13_-_47106176 1.251 ENSMUST00000021807.6
ENSMUST00000135278.1
Dek

DEK oncogene (DNA binding)

chr10_-_77515775 1.247 ENSMUST00000045454.7
Fam207a
family with sequence similarity 207, member A
chr2_+_30286406 1.242 ENSMUST00000138666.1
ENSMUST00000113634.2
Nup188

nucleoporin 188

chr1_-_191907527 1.240 ENSMUST00000069573.5
1700034H15Rik
RIKEN cDNA 1700034H15 gene
chr18_-_34931931 1.227 ENSMUST00000180351.1
Etf1
eukaryotic translation termination factor 1
chr9_+_118478344 1.221 ENSMUST00000035020.8
Eomes
eomesodermin homolog (Xenopus laevis)
chr11_-_66525795 1.196 ENSMUST00000123454.1
Shisa6
shisa homolog 6 (Xenopus laevis)
chr12_+_69372112 1.191 ENSMUST00000050063.7
Arf6
ADP-ribosylation factor 6
chr11_-_100759942 1.181 ENSMUST00000107363.2
Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr1_+_36068371 1.158 ENSMUST00000088174.3
Hs6st1
heparan sulfate 6-O-sulfotransferase 1
chr16_-_96127604 1.132 ENSMUST00000133885.1
ENSMUST00000050884.7
Hmgn1

high mobility group nucleosomal binding domain 1

chr2_-_26352067 1.130 ENSMUST00000028295.8
Dnlz
DNL-type zinc finger
chr6_-_117907753 1.113 ENSMUST00000035534.4
4933440N22Rik
RIKEN cDNA 4933440N22 gene
chr7_-_62420139 1.112 ENSMUST00000094340.3
Mkrn3
makorin, ring finger protein, 3
chr6_-_124965248 1.089 ENSMUST00000129976.1
Cops7a
COP9 (constitutive photomorphogenic) homolog, subunit 7a (Arabidopsis thaliana)
chr5_+_122158265 1.082 ENSMUST00000102528.4
ENSMUST00000086294.6
Ppp1cc

protein phosphatase 1, catalytic subunit, gamma isoform

chr7_+_97696634 1.076 ENSMUST00000026506.4
Clns1a
chloride channel, nucleotide-sensitive, 1A
chr2_-_131160006 1.073 ENSMUST00000103188.3
ENSMUST00000133602.1
ENSMUST00000028800.5
1700037H04Rik


RIKEN cDNA 1700037H04 gene


chr3_+_89773562 1.060 ENSMUST00000038356.8
Ube2q1
ubiquitin-conjugating enzyme E2Q (putative) 1
chr7_-_139582790 1.060 ENSMUST00000106095.2
Nkx6-2
NK6 homeobox 2
chr11_+_100545607 1.052 ENSMUST00000092684.5
ENSMUST00000006976.7
Ttc25

tetratricopeptide repeat domain 25

chrX_+_20688379 1.047 ENSMUST00000033380.6
Cdk16
cyclin-dependent kinase 16
chr2_+_144368961 1.047 ENSMUST00000028911.8
ENSMUST00000147747.1
ENSMUST00000183618.1
Csrp2bp

Pet117
cysteine and glycine-rich protein 2 binding protein

PET117 homolog (S. cerevisiae)
chr13_+_73330982 1.041 ENSMUST00000022098.8
Mrpl36
mitochondrial ribosomal protein L36
chr10_+_127739516 1.029 ENSMUST00000054287.7
Zbtb39
zinc finger and BTB domain containing 39
chr4_+_123904832 1.020 ENSMUST00000030400.7
Mycbp
c-myc binding protein
chr6_-_31563978 0.994 ENSMUST00000026698.7
Podxl
podocalyxin-like
chr12_+_83950608 0.975 ENSMUST00000053744.7
2410016O06Rik
RIKEN cDNA 2410016O06 gene
chr11_-_116853083 0.971 ENSMUST00000092404.6
Srsf2
serine/arginine-rich splicing factor 2
chr15_+_79028212 0.959 ENSMUST00000180086.1
H1f0
H1 histone family, member 0
chr17_-_65613521 0.950 ENSMUST00000024897.8
Vapa
vesicle-associated membrane protein, associated protein A
chr10_+_95515116 0.950 ENSMUST00000099329.3
Ube2n
ubiquitin-conjugating enzyme E2N
chr10_-_62486772 0.923 ENSMUST00000105447.3
Vps26a
vacuolar protein sorting 26 homolog A (yeast)
chr5_+_148265202 0.922 ENSMUST00000110515.2
Mtus2
microtubule associated tumor suppressor candidate 2
chr8_-_69974367 0.918 ENSMUST00000116463.2
Gatad2a
GATA zinc finger domain containing 2A
chr6_-_86526164 0.903 ENSMUST00000053015.5
Pcbp1
poly(rC) binding protein 1
chr15_-_75909543 0.898 ENSMUST00000123712.1
ENSMUST00000141475.1
ENSMUST00000144614.1
Eef1d


eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)


chr18_+_67800101 0.892 ENSMUST00000025425.5
Cep192
centrosomal protein 192
chrX_-_106221145 0.891 ENSMUST00000113495.2
Taf9b
TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr2_+_103970115 0.883 ENSMUST00000111143.1
ENSMUST00000138815.1
Lmo2

LIM domain only 2

chr11_-_29547820 0.851 ENSMUST00000102844.3
Rps27a
ribosomal protein S27A
chr5_+_26817357 0.826 ENSMUST00000071500.6
Dpp6
dipeptidylpeptidase 6
chr13_-_41220162 0.809 ENSMUST00000117096.1
Elovl2
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2
chr1_+_92906959 0.806 ENSMUST00000060913.6
Dusp28
dual specificity phosphatase 28
chr11_-_100527862 0.803 ENSMUST00000107385.1
Acly
ATP citrate lyase
chr10_-_127522428 0.795 ENSMUST00000026470.4
Shmt2
serine hydroxymethyltransferase 2 (mitochondrial)
chr3_-_146839365 0.790 ENSMUST00000084614.3
Gm10288
predicted gene 10288
chr9_-_106887000 0.774 ENSMUST00000055843.7
Rbm15b
RNA binding motif protein 15B
chr9_+_50617516 0.748 ENSMUST00000141366.1
Pih1d2
PIH1 domain containing 2
chr6_-_124965207 0.745 ENSMUST00000148485.1
Cops7a
COP9 (constitutive photomorphogenic) homolog, subunit 7a (Arabidopsis thaliana)
chr11_+_3202612 0.741 ENSMUST00000110049.1
Eif4enif1
eukaryotic translation initiation factor 4E nuclear import factor 1
chr6_-_65144908 0.737 ENSMUST00000031982.4
Hpgds
hematopoietic prostaglandin D synthase
chr4_+_123904907 0.733 ENSMUST00000106202.3
Mycbp
c-myc binding protein
chr3_-_89213840 0.727 ENSMUST00000173477.1
ENSMUST00000119222.1
Mtx1

metaxin 1

chr2_-_38712195 0.726 ENSMUST00000112883.1
Nr5a1
nuclear receptor subfamily 5, group A, member 1
chr19_-_4615647 0.723 ENSMUST00000113822.2
Lrfn4
leucine rich repeat and fibronectin type III domain containing 4
chr8_-_70510322 0.717 ENSMUST00000140679.1
ENSMUST00000129909.1
ENSMUST00000081940.4
Uba52


ubiquitin A-52 residue ribosomal protein fusion product 1


chr15_+_94543666 0.713 ENSMUST00000109248.1
Irak4
interleukin-1 receptor-associated kinase 4
chr2_+_158028481 0.709 ENSMUST00000103123.3
Rprd1b
regulation of nuclear pre-mRNA domain containing 1B
chr8_-_107588392 0.703 ENSMUST00000044106.4
Psmd7
proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
chr7_-_141475131 0.703 ENSMUST00000043870.8
Polr2l
polymerase (RNA) II (DNA directed) polypeptide L
chr17_+_28232723 0.696 ENSMUST00000002320.8
Ppard
peroxisome proliferator activator receptor delta
chr8_-_70510552 0.694 ENSMUST00000125184.1
Uba52
ubiquitin A-52 residue ribosomal protein fusion product 1
chr2_+_158028687 0.690 ENSMUST00000109518.1
ENSMUST00000029180.7
Rprd1b

regulation of nuclear pre-mRNA domain containing 1B

chr4_-_135353164 0.679 ENSMUST00000084846.5
ENSMUST00000136342.2
ENSMUST00000105861.1
Srrm1


serine/arginine repetitive matrix 1


chr2_-_30286312 0.669 ENSMUST00000100219.3
Dolk
dolichol kinase
chr17_-_15498263 0.654 ENSMUST00000014913.9
Psmb1
proteasome (prosome, macropain) subunit, beta type 1
chr17_+_8165501 0.648 ENSMUST00000097419.3
ENSMUST00000024636.8
Fgfr1op

Fgfr1 oncogene partner


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
6.6 59.6 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
3.9 15.5 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
3.3 13.2 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
3.1 12.4 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
2.5 10.2 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
2.4 9.6 GO:0003360 brainstem development(GO:0003360)
1.8 5.4 GO:0018298 protein-chromophore linkage(GO:0018298)
1.8 5.3 GO:0003195 tricuspid valve formation(GO:0003195) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
1.3 3.9 GO:0060167 regulation of adenosine receptor signaling pathway(GO:0060167) regulation of G-protein coupled receptor internalization(GO:1904020)
1.3 6.3 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
1.1 4.4 GO:0006545 glycine biosynthetic process(GO:0006545)
1.0 2.9 GO:2000501 natural killer cell chemotaxis(GO:0035747) regulation of natural killer cell chemotaxis(GO:2000501)
0.9 5.2 GO:0035087 siRNA loading onto RISC involved in RNA interference(GO:0035087)
0.8 2.5 GO:0014738 regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900)
0.8 4.1 GO:0070197 meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240)
0.7 2.2 GO:0060399 positive regulation of growth hormone receptor signaling pathway(GO:0060399)
0.7 5.0 GO:0046549 phenol-containing compound catabolic process(GO:0019336) retinal cone cell development(GO:0046549)
0.7 3.3 GO:0090521 glomerular visceral epithelial cell migration(GO:0090521)
0.6 3.1 GO:0048133 NK T cell differentiation(GO:0001865) germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138) germline stem cell asymmetric division(GO:0098728)
0.6 2.5 GO:0060032 notochord regression(GO:0060032)
0.6 3.1 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.6 1.8 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.6 2.4 GO:0014722 regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
0.6 1.7 GO:0006011 UDP-glucose metabolic process(GO:0006011) glucose 1-phosphate metabolic process(GO:0019255)
0.5 7.4 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.5 2.6 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.5 3.1 GO:0034587 piRNA metabolic process(GO:0034587)
0.5 1.5 GO:0071707 immunoglobulin heavy chain V-D-J recombination(GO:0071707)
0.5 1.5 GO:0033122 regulation of purine nucleotide catabolic process(GO:0033121) negative regulation of purine nucleotide catabolic process(GO:0033122) regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051342) negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
0.5 3.8 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.5 4.2 GO:0001842 neural fold formation(GO:0001842)
0.5 2.3 GO:0072757 cellular response to camptothecin(GO:0072757)
0.4 2.6 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.4 4.3 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.4 1.3 GO:0009174 UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.4 1.2 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.4 2.7 GO:0089700 protein kinase D signaling(GO:0089700)
0.4 2.7 GO:0019262 N-acetylneuraminate catabolic process(GO:0019262)
0.4 2.3 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535) macropinocytosis(GO:0044351)
0.4 1.1 GO:0000720 pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)
0.4 2.5 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.3 1.3 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.3 1.9 GO:0071394 cellular response to testosterone stimulus(GO:0071394)
0.3 1.5 GO:0006680 glucosylceramide catabolic process(GO:0006680)
0.3 1.5 GO:0045578 negative regulation of B cell differentiation(GO:0045578)
0.3 1.6 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.3 1.3 GO:2001032 regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.2 0.7 GO:2000195 negative regulation of female gonad development(GO:2000195)
0.2 1.4 GO:0006528 asparagine metabolic process(GO:0006528)
0.2 1.9 GO:0043201 response to leucine(GO:0043201) cellular response to leucine(GO:0071233)
0.2 2.5 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.2 3.0 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.2 0.6 GO:1905051 regulation of base-excision repair(GO:1905051) positive regulation of base-excision repair(GO:1905053)
0.2 3.2 GO:0007220 Notch receptor processing(GO:0007220)
0.2 1.1 GO:0070459 prolactin secretion(GO:0070459)
0.2 0.6 GO:2000054 regulation of chondrocyte development(GO:0061181) negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.2 5.3 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.2 1.4 GO:0006621 protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.2 0.6 GO:1905223 epicardium morphogenesis(GO:1905223)
0.2 1.8 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.2 1.2 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.2 1.9 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.2 3.5 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.2 1.5 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.2 0.5 GO:0045617 negative regulation of keratinocyte differentiation(GO:0045617)
0.2 0.4 GO:1990523 bone regeneration(GO:1990523)
0.2 0.7 GO:0006776 vitamin A metabolic process(GO:0006776)
0.2 2.8 GO:0000338 protein deneddylation(GO:0000338)
0.2 0.9 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
0.2 3.3 GO:0038092 nodal signaling pathway(GO:0038092)
0.2 1.1 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.1 1.0 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.1 1.4 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.1 0.4 GO:0014063 negative regulation of serotonin secretion(GO:0014063)
0.1 3.6 GO:0035067 negative regulation of histone acetylation(GO:0035067)
0.1 0.5 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.1 2.1 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.1 3.2 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.1 2.5 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.1 4.3 GO:0009409 response to cold(GO:0009409)
0.1 0.4 GO:0060468 prevention of polyspermy(GO:0060468)
0.1 2.9 GO:0045672 positive regulation of osteoclast differentiation(GO:0045672)
0.1 4.8 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.1 1.1 GO:0045794 negative regulation of cell volume(GO:0045794)
0.1 0.3 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241)
0.1 1.7 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.1 2.9 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 0.5 GO:0010993 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.1 0.3 GO:0071929 alpha-tubulin acetylation(GO:0071929)
0.1 0.2 GO:0034392 negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.1 1.1 GO:0006415 translational termination(GO:0006415)
0.1 0.9 GO:0033182 regulation of histone ubiquitination(GO:0033182)
0.1 3.1 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.1 1.2 GO:0034143 regulation of toll-like receptor 4 signaling pathway(GO:0034143)
0.1 0.5 GO:0075525 viral translational termination-reinitiation(GO:0075525)
0.1 1.5 GO:0030574 collagen catabolic process(GO:0030574)
0.1 2.7 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.1 0.6 GO:0006105 succinate metabolic process(GO:0006105)
0.1 2.1 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.1 0.4 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.1 0.5 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.1 5.1 GO:0051384 response to glucocorticoid(GO:0051384)
0.1 0.9 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.1 1.4 GO:0031065 positive regulation of histone deacetylation(GO:0031065)
0.1 3.0 GO:0021591 ventricular system development(GO:0021591)
0.1 0.4 GO:0007603 phototransduction, visible light(GO:0007603)
0.1 1.1 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 8.1 GO:0050772 positive regulation of axonogenesis(GO:0050772)
0.1 1.0 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.1 0.6 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.1 0.8 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.1 1.3 GO:2001273 regulation of glucose import in response to insulin stimulus(GO:2001273)
0.1 2.8 GO:0060325 face morphogenesis(GO:0060325)
0.1 0.6 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.1 0.8 GO:0090308 regulation of methylation-dependent chromatin silencing(GO:0090308)
0.1 1.5 GO:0045776 negative regulation of blood pressure(GO:0045776)
0.1 0.2 GO:0061198 response to trichostatin A(GO:0035983) cellular response to trichostatin A(GO:0035984) fungiform papilla formation(GO:0061198)
0.0 1.2 GO:0007020 microtubule nucleation(GO:0007020)
0.0 0.5 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.0 2.8 GO:0006661 phosphatidylinositol biosynthetic process(GO:0006661)
0.0 0.9 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
0.0 0.1 GO:0043686 co-translational protein modification(GO:0043686)
0.0 0.3 GO:0045583 regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585)
0.0 0.1 GO:0071287 cellular response to manganese ion(GO:0071287)
0.0 0.6 GO:0034453 microtubule anchoring(GO:0034453)
0.0 0.4 GO:0043586 tongue development(GO:0043586)
0.0 1.0 GO:0030252 growth hormone secretion(GO:0030252)
0.0 2.0 GO:0007019 microtubule depolymerization(GO:0007019)
0.0 2.2 GO:0051291 protein heterooligomerization(GO:0051291)
0.0 0.7 GO:0002446 neutrophil mediated immunity(GO:0002446)
0.0 1.6 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 0.4 GO:0090435 protein localization to nuclear envelope(GO:0090435)
0.0 1.4 GO:0009261 purine ribonucleotide catabolic process(GO:0009154) ribonucleotide catabolic process(GO:0009261)
0.0 0.2 GO:0072643 interferon-gamma secretion(GO:0072643)
0.0 0.0 GO:1902416 positive regulation of mRNA binding(GO:1902416) positive regulation of RNA binding(GO:1905216)
0.0 1.0 GO:0006414 translational elongation(GO:0006414)
0.0 0.1 GO:0002756 MyD88-independent toll-like receptor signaling pathway(GO:0002756)
0.0 0.4 GO:0007608 sensory perception of smell(GO:0007608)
0.0 1.4 GO:0033045 regulation of sister chromatid segregation(GO:0033045)
0.0 0.5 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.8 GO:0019228 neuronal action potential(GO:0019228)
0.0 0.8 GO:0031648 protein destabilization(GO:0031648)
0.0 2.0 GO:0045089 positive regulation of innate immune response(GO:0045089)
0.0 3.4 GO:0007411 axon guidance(GO:0007411)
0.0 0.1 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.0 1.7 GO:0006626 protein targeting to mitochondrion(GO:0006626)
0.0 0.6 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 0.9 GO:0030307 positive regulation of cell growth(GO:0030307)
0.0 1.1 GO:0048024 regulation of mRNA splicing, via spliceosome(GO:0048024)
0.0 0.2 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.0 0.7 GO:0045665 negative regulation of neuron differentiation(GO:0045665)
0.0 0.2 GO:0006406 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 9.6 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.8 3.3 GO:0090537 CERF complex(GO:0090537)
0.7 3.3 GO:0044611 nuclear pore inner ring(GO:0044611)
0.6 3.8 GO:0000235 astral microtubule(GO:0000235)
0.6 3.3 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.5 6.3 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.5 4.3 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.4 1.3 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.4 1.9 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.3 1.0 GO:0035061 interchromatin granule(GO:0035061)
0.3 0.9 GO:0031372 UBC13-MMS2 complex(GO:0031372)
0.3 4.3 GO:0035686 sperm fibrous sheath(GO:0035686)
0.3 5.5 GO:0016580 Sin3 complex(GO:0016580)
0.3 4.1 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.2 2.6 GO:0005642 annulate lamellae(GO:0005642)
0.2 3.0 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.2 0.9 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.2 1.1 GO:0034715 pICln-Sm protein complex(GO:0034715)
0.2 1.8 GO:0070578 RISC-loading complex(GO:0070578)
0.2 2.2 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.2 0.8 GO:0070552 BRISC complex(GO:0070552)
0.2 2.5 GO:0097542 ciliary tip(GO:0097542)
0.2 7.4 GO:0032809 neuronal cell body membrane(GO:0032809)
0.2 1.0 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.2 3.5 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.2 2.8 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.1 0.6 GO:0045283 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.1 1.8 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 0.6 GO:0099524 region of cytosol(GO:0099522) postsynaptic cytosol(GO:0099524)
0.1 1.3 GO:0044754 secondary lysosome(GO:0005767) autolysosome(GO:0044754)
0.1 2.7 GO:0000421 autophagosome membrane(GO:0000421)
0.1 2.4 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 2.1 GO:0035102 PRC1 complex(GO:0035102)
0.1 2.3 GO:0005682 U5 snRNP(GO:0005682)
0.1 16.9 GO:0030139 endocytic vesicle(GO:0030139)
0.1 1.0 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 1.6 GO:0042788 polysomal ribosome(GO:0042788)
0.1 3.5 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 1.5 GO:0031011 Ino80 complex(GO:0031011)
0.1 0.2 GO:0044194 cytolytic granule(GO:0044194)
0.1 0.4 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.1 1.7 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.1 3.5 GO:0005719 nuclear euchromatin(GO:0005719)
0.1 1.3 GO:0032156 septin cytoskeleton(GO:0032156)
0.1 2.8 GO:0008180 COP9 signalosome(GO:0008180)
0.1 0.5 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.1 2.4 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.1 0.5 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 0.7 GO:0005838 proteasome regulatory particle(GO:0005838)
0.1 7.0 GO:0031225 anchored component of membrane(GO:0031225)
0.1 1.2 GO:0000242 pericentriolar material(GO:0000242)
0.1 0.7 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 3.1 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 5.2 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 4.0 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.4 GO:0070652 HAUS complex(GO:0070652)
0.0 3.9 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 2.2 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.5 GO:0032433 filopodium tip(GO:0032433)
0.0 0.2 GO:0033391 chromatoid body(GO:0033391)
0.0 3.7 GO:0030018 Z disc(GO:0030018)
0.0 4.2 GO:0022626 cytosolic ribosome(GO:0022626)
0.0 0.5 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.6 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 16.1 GO:0005813 centrosome(GO:0005813)
0.0 1.4 GO:0005801 cis-Golgi network(GO:0005801)
0.0 1.9 GO:0005643 nuclear pore(GO:0005643)
0.0 0.2 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 27.5 GO:0005615 extracellular space(GO:0005615)
0.0 1.4 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 2.8 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 0.2 GO:0017119 Golgi transport complex(GO:0017119)
0.0 1.3 GO:0043292 contractile fiber(GO:0043292)
0.0 0.8 GO:0005844 polysome(GO:0005844)
0.0 0.8 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 0.8 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.4 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.6 GO:0031519 PcG protein complex(GO:0031519)
0.0 1.2 GO:0016605 PML body(GO:0016605)
0.0 1.6 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 0.5 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 15.5 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
1.8 5.4 GO:0009881 photoreceptor activity(GO:0009881)
1.8 5.3 GO:0035939 microsatellite binding(GO:0035939)
1.6 9.6 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
1.5 59.9 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
1.5 4.4 GO:0008732 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
1.3 6.3 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
1.0 3.9 GO:0031687 A2A adenosine receptor binding(GO:0031687)
0.7 4.3 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.6 2.5 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.6 2.5 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.6 3.3 GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.5 4.3 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.5 2.5 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.4 2.9 GO:0016018 cyclosporin A binding(GO:0016018)
0.4 1.5 GO:0070976 calcium-independent protein kinase C activity(GO:0004699) TIR domain binding(GO:0070976)
0.4 1.4 GO:0046923 ER retention sequence binding(GO:0046923)
0.3 3.5 GO:0035197 siRNA binding(GO:0035197)
0.3 1.9 GO:0033142 progesterone receptor binding(GO:0033142)
0.3 3.1 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.3 1.2 GO:0033883 pyridoxal phosphatase activity(GO:0033883)
0.3 1.2 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.3 11.0 GO:0070412 R-SMAD binding(GO:0070412)
0.3 2.7 GO:0004697 protein kinase C activity(GO:0004697)
0.3 6.3 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.2 2.2 GO:0061133 endopeptidase activator activity(GO:0061133)
0.2 2.1 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.2 0.7 GO:0016501 prostacyclin receptor activity(GO:0016501)
0.2 0.6 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.2 0.6 GO:0008534 oxidized purine nucleobase lesion DNA N-glycosylase activity(GO:0008534)
0.2 2.5 GO:0031996 thioesterase binding(GO:0031996)
0.2 0.6 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177) 3 iron, 4 sulfur cluster binding(GO:0051538)
0.2 1.4 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.2 7.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.2 0.7 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.2 13.9 GO:0019955 cytokine binding(GO:0019955)
0.2 5.3 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.2 1.9 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.2 1.5 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.2 1.5 GO:0030274 LIM domain binding(GO:0030274)
0.2 2.6 GO:0017070 U6 snRNA binding(GO:0017070)
0.2 2.7 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.2 1.7 GO:0032557 pyrimidine ribonucleotide binding(GO:0032557)
0.2 0.9 GO:0008494 translation activator activity(GO:0008494)
0.1 1.5 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.1 2.4 GO:0051920 peroxiredoxin activity(GO:0051920)
0.1 3.3 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 0.8 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 0.5 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.1 3.2 GO:0030371 translation repressor activity(GO:0030371)
0.1 0.6 GO:0001069 regulatory region RNA binding(GO:0001069)
0.1 2.5 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.1 0.9 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.1 0.2 GO:0035851 Krueppel-associated box domain binding(GO:0035851)
0.1 1.6 GO:0008266 poly(U) RNA binding(GO:0008266)
0.1 3.0 GO:0070840 dynein complex binding(GO:0070840)
0.1 2.9 GO:0008009 chemokine activity(GO:0008009)
0.1 1.8 GO:0051787 misfolded protein binding(GO:0051787)
0.1 0.6 GO:0070411 I-SMAD binding(GO:0070411)
0.1 2.5 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 1.0 GO:0003680 AT DNA binding(GO:0003680)
0.1 7.9 GO:0033613 activating transcription factor binding(GO:0033613)
0.1 0.5 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.1 3.5 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.1 0.9 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.1 0.7 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.1 1.5 GO:0000400 four-way junction DNA binding(GO:0000400)
0.1 6.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 2.0 GO:0030276 clathrin binding(GO:0030276)
0.1 0.3 GO:0010484 H3 histone acetyltransferase activity(GO:0010484)
0.1 4.7 GO:0019003 GDP binding(GO:0019003)
0.1 3.1 GO:0004521 endoribonuclease activity(GO:0004521)
0.1 0.5 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 2.8 GO:0005158 insulin receptor binding(GO:0005158)
0.1 0.5 GO:0005047 signal recognition particle binding(GO:0005047)
0.1 12.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 0.4 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 4.1 GO:0004519 endonuclease activity(GO:0004519)
0.1 1.9 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.1 0.7 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1 1.1 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 1.7 GO:0005112 Notch binding(GO:0005112)
0.0 0.6 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 4.0 GO:0003777 microtubule motor activity(GO:0003777)
0.0 2.0 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.4 GO:0008227 G-protein coupled amine receptor activity(GO:0008227)
0.0 1.3 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.6 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.0 0.7 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 0.6 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 1.4 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0 1.0 GO:0001671 ATPase activator activity(GO:0001671)
0.0 6.9 GO:0042393 histone binding(GO:0042393)
0.0 0.5 GO:0005521 lamin binding(GO:0005521)
0.0 1.4 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.4 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 1.3 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763) carboxy-lyase activity(GO:0016831)
0.0 0.1 GO:0043682 copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682)
0.0 3.8 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.4 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.6 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 1.3 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.8 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 0.7 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0 0.3 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 1.5 GO:0031072 heat shock protein binding(GO:0031072)
0.0 1.3 GO:0005506 iron ion binding(GO:0005506)
0.0 1.9 GO:0001047 core promoter binding(GO:0001047)
0.0 0.4 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 0.2 GO:0003746 translation elongation factor activity(GO:0003746)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 63.1 PID_IGF1_PATHWAY IGF1 pathway
0.4 10.7 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.2 7.5 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.2 11.2 PID_BMP_PATHWAY BMP receptor signaling
0.2 14.5 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.1 2.7 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 6.8 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.1 11.9 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 1.1 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.1 5.7 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 1.4 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.1 2.0 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.1 2.8 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.1 2.6 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.1 5.4 PID_CDC42_PATHWAY CDC42 signaling events
0.1 2.8 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.1 2.2 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 1.3 PID_CD40_PATHWAY CD40/CD40L signaling
0.1 3.5 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 0.7 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.1 0.6 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.1 3.5 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 1.4 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 0.6 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 2.5 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.8 PID_IL1_PATHWAY IL1-mediated signaling events
0.0 0.7 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 1.2 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 1.6 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 4.5 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 0.6 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 1.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 59.6 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.5 8.7 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.5 5.0 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.4 13.2 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.3 7.4 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.3 2.5 REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS Genes involved in Glucagon-type ligand receptors
0.3 4.2 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.3 2.3 REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.2 16.0 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.2 1.8 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.2 0.2 REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.2 3.3 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.2 3.3 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2 1.7 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.2 27.4 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.2 2.9 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events
0.2 5.2 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.1 1.6 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.1 4.3 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 1.7 REACTOME_SIGNALING_BY_NOTCH1 Genes involved in Signaling by NOTCH1
0.1 1.5 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1 0.8 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION_IN_TLR7_8_OR_9_SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.1 4.3 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 3.0 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.1 2.4 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.1 1.3 REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.1 5.1 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 4.5 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.1 3.4 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 1.1 REACTOME_METABOLISM_OF_NON_CODING_RNA Genes involved in Metabolism of non-coding RNA
0.1 1.0 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 1.0 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 1.3 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.1 0.5 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 1.7 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.1 1.5 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 1.2 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.8 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 1.0 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.0 2.1 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.7 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 2.3 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.3 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.6 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.6 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 3.4 REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_BY_THE_EXON_JUNCTION_COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.0 1.9 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 1.5 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.0 0.6 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.0 5.9 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.2 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 1.4 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.5 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels