Motif ID: Msx2_Hoxd4

Z-value: 1.138

Transcription factors associated with Msx2_Hoxd4:

Gene SymbolEntrez IDGene Name
Msx2 ENSMUSG00000021469.8 Msx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Msx2mm10_v2_chr13_-_53473074_53473074-0.324.3e-02Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Msx2_Hoxd4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_62766153 15.235 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr1_-_190170671 9.647 ENSMUST00000175916.1
Prox1
prospero-related homeobox 1
chr1_-_190170178 8.440 ENSMUST00000177288.1
Prox1
prospero-related homeobox 1
chr2_+_4017727 7.680 ENSMUST00000177457.1
Frmd4a
FERM domain containing 4A
chr2_-_63184253 7.579 ENSMUST00000075052.3
ENSMUST00000112454.1
Kcnh7

potassium voltage-gated channel, subfamily H (eag-related), member 7

chr3_+_62419668 6.707 ENSMUST00000161057.1
Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr3_-_85741389 6.201 ENSMUST00000094148.4
Fam160a1
family with sequence similarity 160, member A1
chr6_-_36811361 6.197 ENSMUST00000101534.1
Ptn
pleiotrophin
chr14_-_88471396 6.101 ENSMUST00000061628.5
Pcdh20
protocadherin 20
chr3_-_49757257 5.754 ENSMUST00000035931.7
Pcdh18
protocadherin 18
chr1_-_163725123 5.642 ENSMUST00000159679.1
Mettl11b
methyltransferase like 11B
chr2_-_63184170 5.156 ENSMUST00000112452.1
Kcnh7
potassium voltage-gated channel, subfamily H (eag-related), member 7
chr1_+_165788681 4.200 ENSMUST00000161971.1
ENSMUST00000178336.1
ENSMUST00000005907.5
ENSMUST00000027849.4
Cd247



CD247 antigen



chr1_+_159737510 3.947 ENSMUST00000111669.3
Tnr
tenascin R
chr5_-_62765618 3.741 ENSMUST00000159470.1
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr15_+_21111452 3.448 ENSMUST00000075132.6
Cdh12
cadherin 12
chr1_+_165788746 3.370 ENSMUST00000161559.2
Cd247
CD247 antigen
chrX_+_101640056 3.089 ENSMUST00000119299.1
ENSMUST00000044475.4
Ogt

O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)

chr7_+_96522342 2.784 ENSMUST00000129737.1
Tenm4
teneurin transmembrane protein 4
chr18_+_52767994 2.580 ENSMUST00000025413.7
ENSMUST00000163742.2
ENSMUST00000178011.1
Sncaip


synuclein, alpha interacting protein (synphilin)


chr2_-_144527341 2.364 ENSMUST00000163701.1
ENSMUST00000081982.5
Dzank1

double zinc ribbon and ankyrin repeat domains 1

chr4_+_124657646 2.274 ENSMUST00000053491.7
Pou3f1
POU domain, class 3, transcription factor 1
chr7_-_73537621 2.273 ENSMUST00000172704.1
Chd2
chromodomain helicase DNA binding protein 2
chrX_+_159708593 2.234 ENSMUST00000080394.6
Sh3kbp1
SH3-domain kinase binding protein 1
chr2_-_33086366 2.180 ENSMUST00000049618.2
Garnl3
GTPase activating RANGAP domain-like 3
chr7_+_126950518 2.085 ENSMUST00000106335.1
ENSMUST00000146017.1
Sez6l2

seizure related 6 homolog like 2

chr3_+_138065052 2.067 ENSMUST00000163080.2
1110002E22Rik
RIKEN cDNA 1110002E22 gene
chr11_+_103133303 2.036 ENSMUST00000107037.1
Hexim2
hexamethylene bis-acetamide inducible 2
chr3_-_146495115 2.018 ENSMUST00000093951.2
Spata1
spermatogenesis associated 1
chrX_+_56454871 1.993 ENSMUST00000039374.2
ENSMUST00000101553.2
Ddx26b

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B

chr17_-_90088343 1.976 ENSMUST00000173917.1
Nrxn1
neurexin I
chr18_+_37513652 1.944 ENSMUST00000061405.4
Pcdhb21
protocadherin beta 21
chr9_+_22454290 1.937 ENSMUST00000168332.1
Gm17545
predicted gene, 17545
chr6_-_136171722 1.865 ENSMUST00000053880.6
Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr17_-_25785324 1.856 ENSMUST00000150324.1
Haghl
hydroxyacylglutathione hydrolase-like
chr8_-_120228221 1.849 ENSMUST00000183235.1
A330074K22Rik
RIKEN cDNA A330074K22 gene
chr3_-_66296807 1.831 ENSMUST00000029419.7
Veph1
ventricular zone expressed PH domain-containing 1
chr19_+_26749726 1.795 ENSMUST00000175842.1
Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chrX_+_150547375 1.761 ENSMUST00000066337.6
ENSMUST00000112715.1
Alas2

aminolevulinic acid synthase 2, erythroid

chr6_+_136518820 1.743 ENSMUST00000032335.6
Atf7ip
activating transcription factor 7 interacting protein
chr18_-_37969742 1.718 ENSMUST00000166148.1
ENSMUST00000163131.1
ENSMUST00000043437.7
Fchsd1


FCH and double SH3 domains 1


chr16_-_44016387 1.707 ENSMUST00000036174.3
Gramd1c
GRAM domain containing 1C
chr4_-_129121889 1.686 ENSMUST00000139450.1
ENSMUST00000125931.1
ENSMUST00000116444.2
Hpca


hippocalcin


chr11_+_103133333 1.673 ENSMUST00000124928.1
ENSMUST00000062530.4
Hexim2

hexamethylene bis-acetamide inducible 2

chr7_+_126950687 1.649 ENSMUST00000106333.1
Sez6l2
seizure related 6 homolog like 2
chr10_+_39612934 1.638 ENSMUST00000019987.6
Traf3ip2
TRAF3 interacting protein 2
chr17_-_46327949 1.612 ENSMUST00000047970.7
Abcc10
ATP-binding cassette, sub-family C (CFTR/MRP), member 10
chr3_+_68869563 1.605 ENSMUST00000054551.2
1110032F04Rik
RIKEN cDNA 1110032F04 gene
chr5_-_107875035 1.598 ENSMUST00000138111.1
ENSMUST00000112642.1
Evi5

ecotropic viral integration site 5

chr7_-_73541738 1.587 ENSMUST00000169922.2
Chd2
chromodomain helicase DNA binding protein 2
chr12_+_36314160 1.560 ENSMUST00000041407.5
Sostdc1
sclerostin domain containing 1
chr1_+_180109192 1.557 ENSMUST00000143176.1
ENSMUST00000135056.1
Cdc42bpa

CDC42 binding protein kinase alpha

chr15_-_79285502 1.548 ENSMUST00000165408.1
Baiap2l2
BAI1-associated protein 2-like 2
chr3_+_52268337 1.526 ENSMUST00000053764.5
Foxo1
forkhead box O1
chr2_-_45112890 1.502 ENSMUST00000076836.6
Zeb2
zinc finger E-box binding homeobox 2
chr7_+_126950837 1.445 ENSMUST00000106332.1
Sez6l2
seizure related 6 homolog like 2
chr7_-_121074501 1.408 ENSMUST00000047194.2
Igsf6
immunoglobulin superfamily, member 6
chr4_-_40722307 1.395 ENSMUST00000181475.1
Gm6297
predicted gene 6297
chrX_-_8132770 1.384 ENSMUST00000130832.1
ENSMUST00000033506.6
ENSMUST00000115623.1
ENSMUST00000153839.1
Wdr13



WD repeat domain 13



chr1_-_24612700 1.363 ENSMUST00000088336.1
Gm10222
predicted gene 10222
chrM_+_9870 1.310 ENSMUST00000084013.1
mt-Nd4l
mitochondrially encoded NADH dehydrogenase 4L
chr18_+_37320374 1.280 ENSMUST00000078271.2
Pcdhb5
protocadherin beta 5
chr5_-_84417359 1.245 ENSMUST00000113401.1
Epha5
Eph receptor A5
chr13_+_75967704 1.238 ENSMUST00000022081.1
Spata9
spermatogenesis associated 9
chr2_-_45110336 1.164 ENSMUST00000028229.6
ENSMUST00000152232.1
Zeb2

zinc finger E-box binding homeobox 2

chr5_-_146220901 1.156 ENSMUST00000169407.2
ENSMUST00000161331.1
ENSMUST00000159074.2
ENSMUST00000067837.3
Rnf6



ring finger protein (C3H2C3 type) 6



chr18_+_37518341 1.132 ENSMUST00000097609.1
Pcdhb22
protocadherin beta 22
chr15_+_92597104 1.108 ENSMUST00000035399.8
Pdzrn4
PDZ domain containing RING finger 4
chr12_+_74297474 1.042 ENSMUST00000072100.3
Dbpht2
DNA binding protein with his-thr domain
chr13_+_76098734 1.038 ENSMUST00000091466.3
Ttc37
tetratricopeptide repeat domain 37
chr15_-_37459327 1.026 ENSMUST00000119730.1
ENSMUST00000120746.1
Ncald

neurocalcin delta

chrX_-_143933089 1.020 ENSMUST00000087313.3
Dcx
doublecortin
chr14_-_36919314 1.018 ENSMUST00000182797.1
Ccser2
coiled-coil serine rich 2
chr9_-_55919605 0.997 ENSMUST00000037408.8
Scaper
S phase cyclin A-associated protein in the ER
chr9_-_50739365 0.980 ENSMUST00000117093.1
ENSMUST00000121634.1
Dixdc1

DIX domain containing 1

chr2_-_60125651 0.967 ENSMUST00000112550.1
Baz2b
bromodomain adjacent to zinc finger domain, 2B
chr1_+_33908172 0.949 ENSMUST00000182513.1
ENSMUST00000183034.1
Dst

dystonin

chr16_+_14705832 0.940 ENSMUST00000023356.6
Snai2
snail homolog 2 (Drosophila)
chr19_+_46396885 0.935 ENSMUST00000039922.6
ENSMUST00000111867.2
ENSMUST00000120778.1
Sufu


suppressor of fused homolog (Drosophila)


chr5_-_23616528 0.922 ENSMUST00000088392.4
Srpk2
serine/arginine-rich protein specific kinase 2
chr13_-_95250166 0.840 ENSMUST00000162153.1
ENSMUST00000160957.2
ENSMUST00000159598.1
ENSMUST00000162412.1
Pde8b



phosphodiesterase 8B



chrM_+_10167 0.826 ENSMUST00000082414.1
mt-Nd4
mitochondrially encoded NADH dehydrogenase 4
chr2_+_125136692 0.820 ENSMUST00000099452.2
Ctxn2
cortexin 2
chr18_+_59062462 0.820 ENSMUST00000058633.2
ENSMUST00000175897.1
ENSMUST00000118510.1
ENSMUST00000175830.1
A730017C20Rik



RIKEN cDNA A730017C20 gene



chr15_+_41830921 0.803 ENSMUST00000166917.1
Oxr1
oxidation resistance 1
chr1_+_157458554 0.785 ENSMUST00000046743.4
ENSMUST00000119891.1
BC026585

cDNA sequence BC026585

chr4_-_141078302 0.769 ENSMUST00000030760.8
Necap2
NECAP endocytosis associated 2
chr10_+_128303322 0.757 ENSMUST00000005825.6
Pan2
PAN2 polyA specific ribonuclease subunit homolog (S. cerevisiae)
chr4_-_149126688 0.706 ENSMUST00000030815.2
Cort
cortistatin
chr10_+_75037066 0.678 ENSMUST00000147802.1
ENSMUST00000020391.5
Rab36

RAB36, member RAS oncogene family

chr7_-_29906524 0.652 ENSMUST00000159920.1
ENSMUST00000162592.1
Zfp27

zinc finger protein 27

chr2_-_176144697 0.636 ENSMUST00000178872.1
Gm2004
predicted gene 2004
chr13_-_75943812 0.626 ENSMUST00000022078.5
ENSMUST00000109606.1
Rhobtb3

Rho-related BTB domain containing 3

chrX_-_143933204 0.584 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
Dcx


doublecortin


chr9_+_32116040 0.552 ENSMUST00000174641.1
Arhgap32
Rho GTPase activating protein 32
chr1_+_191025350 0.549 ENSMUST00000181050.1
A230020J21Rik
RIKEN cDNA A230020J21 gene
chr15_-_37458523 0.543 ENSMUST00000116445.2
Ncald
neurocalcin delta
chrX_-_94123359 0.534 ENSMUST00000137853.1
ENSMUST00000088102.5
ENSMUST00000113927.1
Zfx


zinc finger protein X-linked


chr1_-_152625212 0.533 ENSMUST00000027760.7
Rgl1
ral guanine nucleotide dissociation stimulator,-like 1
chr10_-_14718191 0.527 ENSMUST00000020016.4
Gje1
gap junction protein, epsilon 1
chr11_+_95010277 0.511 ENSMUST00000124735.1
Samd14
sterile alpha motif domain containing 14
chr9_-_107770945 0.504 ENSMUST00000183248.1
ENSMUST00000182022.1
ENSMUST00000035199.6
ENSMUST00000182659.1
Rbm5



RNA binding motif protein 5



chr3_+_84952146 0.498 ENSMUST00000029727.7
Fbxw7
F-box and WD-40 domain protein 7
chr6_+_124304646 0.492 ENSMUST00000112541.2
ENSMUST00000032234.2
Cd163

CD163 antigen

chr3_+_19957037 0.448 ENSMUST00000091309.5
ENSMUST00000108329.1
ENSMUST00000003714.6
Cp


ceruloplasmin


chr13_+_51408618 0.433 ENSMUST00000087978.3
S1pr3
sphingosine-1-phosphate receptor 3
chr4_-_82850721 0.424 ENSMUST00000139401.1
Zdhhc21
zinc finger, DHHC domain containing 21
chr7_-_45921418 0.409 ENSMUST00000038876.5
Emp3
epithelial membrane protein 3
chr7_-_45920830 0.408 ENSMUST00000164119.1
Emp3
epithelial membrane protein 3
chr1_-_133661318 0.408 ENSMUST00000027736.6
ENSMUST00000179598.1
Zc3h11a
Zbed6
zinc finger CCCH type containing 11A
zinc finger, BED domain containing 6
chrX_-_150814265 0.405 ENSMUST00000026302.6
ENSMUST00000129768.1
ENSMUST00000112699.2
Maged2


melanoma antigen, family D, 2


chr8_-_70527645 0.391 ENSMUST00000132867.1
Kxd1
KxDL motif containing 1
chr7_+_123123870 0.372 ENSMUST00000094053.5
Tnrc6a
trinucleotide repeat containing 6a
chr9_-_114390633 0.371 ENSMUST00000084881.4
Crtap
cartilage associated protein
chr18_+_34840575 0.355 ENSMUST00000043484.7
Reep2
receptor accessory protein 2
chr15_-_50890396 0.349 ENSMUST00000185183.1
Trps1
trichorhinophalangeal syndrome I (human)
chr3_+_144570687 0.349 ENSMUST00000106211.1
Sep15
selenoprotein
chr11_-_87826023 0.346 ENSMUST00000103177.3
Lpo
lactoperoxidase
chr9_-_89705017 0.343 ENSMUST00000058488.6
Tmed3
transmembrane emp24 domain containing 3
chr1_+_72284367 0.338 ENSMUST00000027380.5
ENSMUST00000141783.1
Tmem169

transmembrane protein 169

chr10_+_127421208 0.336 ENSMUST00000168780.1
R3hdm2
R3H domain containing 2
chr15_+_85510812 0.331 ENSMUST00000079690.2
Gm4825
predicted pseudogene 4825
chr19_-_53371766 0.325 ENSMUST00000086887.1
Gm10197
predicted gene 10197
chr6_-_106800051 0.305 ENSMUST00000013882.7
ENSMUST00000049675.4
ENSMUST00000113239.3
Crbn


cereblon


chr12_-_27160311 0.301 ENSMUST00000182473.1
ENSMUST00000177636.1
ENSMUST00000183238.1
Gm9866


predicted gene 9866


chr12_-_85374696 0.276 ENSMUST00000040766.7
Tmed10
transmembrane emp24-like trafficking protein 10 (yeast)
chrM_+_7759 0.263 ENSMUST00000082407.1
ENSMUST00000082408.1
mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr1_-_72284248 0.257 ENSMUST00000097698.4
ENSMUST00000027381.6
Pecr

peroxisomal trans-2-enoyl-CoA reductase

chr9_-_112187766 0.255 ENSMUST00000111872.2
ENSMUST00000164754.2
Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr18_-_3281712 0.253 ENSMUST00000182204.1
ENSMUST00000154705.1
ENSMUST00000182833.1
ENSMUST00000151084.1
Crem



cAMP responsive element modulator



chr4_+_102570065 0.246 ENSMUST00000097950.2
Pde4b
phosphodiesterase 4B, cAMP specific
chr12_-_76177251 0.237 ENSMUST00000101291.3
ENSMUST00000076634.4
Esr2

estrogen receptor 2 (beta)

chrM_+_2743 0.230 ENSMUST00000082392.1
mt-Nd1
mitochondrially encoded NADH dehydrogenase 1
chr6_+_37870786 0.220 ENSMUST00000120428.1
ENSMUST00000031859.7
Trim24

tripartite motif-containing 24

chr3_+_144570409 0.220 ENSMUST00000082437.3
Sep15
selenoprotein
chr17_+_46161021 0.214 ENSMUST00000024748.7
ENSMUST00000172170.1
Gtpbp2

GTP binding protein 2

chrM_-_14060 0.204 ENSMUST00000082419.1
mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr4_-_148160031 0.189 ENSMUST00000057907.3
Fbxo44
F-box protein 44
chrX_-_74246534 0.178 ENSMUST00000101454.2
ENSMUST00000033699.6
Flna

filamin, alpha

chr7_+_65693417 0.172 ENSMUST00000032726.7
ENSMUST00000107495.3
Tm2d3

TM2 domain containing 3

chr6_+_34746368 0.172 ENSMUST00000142716.1
Cald1
caldesmon 1
chr2_+_76650264 0.153 ENSMUST00000099986.2
Dfnb59
deafness, autosomal recessive 59 (human)
chr13_+_40859768 0.153 ENSMUST00000110191.2
Gcnt2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr17_+_45506825 0.151 ENSMUST00000024733.7
Aars2
alanyl-tRNA synthetase 2, mitochondrial (putative)
chr1_+_63176818 0.128 ENSMUST00000129339.1
Eef1b2
eukaryotic translation elongation factor 1 beta 2
chrX_-_103981242 0.127 ENSMUST00000121153.1
ENSMUST00000070705.4
Rlim

ring finger protein, LIM domain interacting

chr7_-_84679346 0.117 ENSMUST00000069537.2
ENSMUST00000178385.1
Zfand6

zinc finger, AN1-type domain 6

chr4_-_148159838 0.116 ENSMUST00000151127.1
ENSMUST00000105705.2
Fbxo44

F-box protein 44

chr2_+_180710117 0.107 ENSMUST00000029090.2
Gid8
GID complex subunit 8 homolog (S. cerevisiae)
chr10_+_127421124 0.100 ENSMUST00000170336.1
R3hdm2
R3H domain containing 2
chr4_-_62519885 0.090 ENSMUST00000107444.1
ENSMUST00000030090.3
Alad

aminolevulinate, delta-, dehydratase

chr7_+_65693447 0.081 ENSMUST00000143508.1
Tm2d3
TM2 domain containing 3
chr14_+_54259227 0.069 ENSMUST00000041197.7
Abhd4
abhydrolase domain containing 4
chr6_+_34745952 0.060 ENSMUST00000123823.1
ENSMUST00000136907.1
ENSMUST00000126181.1
Cald1


caldesmon 1


chr5_-_31179901 0.055 ENSMUST00000101411.2
ENSMUST00000140793.1
Gtf3c2

general transcription factor IIIC, polypeptide 2, beta

chr1_-_172632931 0.046 ENSMUST00000027826.5
Dusp23
dual specificity phosphatase 23
chr8_+_70527724 0.040 ENSMUST00000119353.2
ENSMUST00000075491.7
Fkbp8

FK506 binding protein 8

chr7_+_97400003 0.025 ENSMUST00000032882.8
Ndufc2
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2
chr4_+_136143497 0.011 ENSMUST00000008016.2
Id3
inhibitor of DNA binding 3
chr1_-_132390301 0.010 ENSMUST00000132435.1
Tmcc2
transmembrane and coiled-coil domains 2

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
6.0 18.1 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
2.1 6.2 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
1.0 3.1 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
1.0 3.9 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.7 2.8 GO:0032289 central nervous system myelin formation(GO:0032289) cardiac cell fate specification(GO:0060912)
0.6 1.7 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
0.5 1.6 GO:2000016 negative regulation of determination of dorsal identity(GO:2000016)
0.5 2.0 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.5 1.9 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.4 2.7 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.3 6.7 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.3 0.9 GO:1901420 negative regulation of response to alcohol(GO:1901420)
0.3 5.8 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.3 0.8 GO:0035106 operant conditioning(GO:0035106)
0.3 7.6 GO:0070207 protein homotrimerization(GO:0070207)
0.2 1.2 GO:0044314 protein K27-linked ubiquitination(GO:0044314)
0.2 5.2 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.2 3.9 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.2 1.8 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.2 1.9 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.2 0.9 GO:0035063 nuclear speck organization(GO:0035063)
0.2 7.7 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.2 0.7 GO:0050913 sensory perception of bitter taste(GO:0050913)
0.2 5.6 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.1 1.5 GO:0071455 cellular response to hyperoxia(GO:0071455)
0.1 1.4 GO:0061469 regulation of type B pancreatic cell proliferation(GO:0061469)
0.1 0.9 GO:0021775 smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
0.1 3.7 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.1 0.5 GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.1 1.2 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.1 9.5 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 1.6 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 1.7 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.1 2.6 GO:0090083 regulation of inclusion body assembly(GO:0090083)
0.1 1.5 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.1 1.6 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.1 0.3 GO:0035964 COPI-coated vesicle budding(GO:0035964)
0.1 1.7 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.1 1.0 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.1 0.2 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.1 2.3 GO:0032292 myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
0.1 13.1 GO:0051291 protein heterooligomerization(GO:0051291)
0.1 0.4 GO:0070294 renal sodium ion transport(GO:0003096) renal sodium ion absorption(GO:0070294)
0.1 0.8 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.1 0.2 GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
0.1 0.9 GO:0008090 retrograde axonal transport(GO:0008090)
0.1 1.9 GO:0006783 heme biosynthetic process(GO:0006783)
0.1 0.2 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.1 0.4 GO:0045602 negative regulation of endothelial cell differentiation(GO:0045602)
0.1 0.2 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.1 1.5 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.1 0.2 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.1 0.7 GO:0045187 regulation of circadian sleep/wake cycle(GO:0042749) regulation of circadian sleep/wake cycle, sleep(GO:0045187)
0.1 0.9 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.8 GO:0000291 nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291)
0.0 0.8 GO:0032060 bleb assembly(GO:0032060)
0.0 0.3 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.0 0.4 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.4 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.0 1.3 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 0.4 GO:0046688 response to copper ion(GO:0046688)
0.0 4.3 GO:0007416 synapse assembly(GO:0007416)
0.0 0.4 GO:0045974 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.0 0.2 GO:0036438 maintenance of lens transparency(GO:0036438)
0.0 0.5 GO:0060746 parental behavior(GO:0060746)
0.0 0.5 GO:0006953 acute-phase response(GO:0006953)
0.0 2.2 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.1 GO:1900095 regulation of dosage compensation by inactivation of X chromosome(GO:1900095)
0.0 0.4 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 1.6 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.0 0.2 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.3 GO:0030497 fatty acid elongation(GO:0030497)
0.0 0.2 GO:0033194 response to hydroperoxide(GO:0033194)
0.0 2.2 GO:0008360 regulation of cell shape(GO:0008360)
0.0 1.0 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 0.5 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 7.6 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
1.3 3.9 GO:0072534 perineuronal net(GO:0072534)
0.3 1.0 GO:0055087 Ski complex(GO:0055087)
0.3 0.8 GO:0031251 PAN complex(GO:0031251)
0.2 0.9 GO:0031673 H zone(GO:0031673)
0.2 2.0 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.2 3.4 GO:0042588 zymogen granule(GO:0042588)
0.2 1.5 GO:0071439 clathrin complex(GO:0071439)
0.1 1.9 GO:0043083 synaptic cleft(GO:0043083)
0.1 1.7 GO:0044327 dendritic spine head(GO:0044327)
0.1 0.5 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.1 1.8 GO:0071564 npBAF complex(GO:0071564)
0.1 7.9 GO:0031594 neuromuscular junction(GO:0031594)
0.1 7.5 GO:0005923 bicellular tight junction(GO:0005923)
0.0 0.2 GO:0031523 Myb complex(GO:0031523)
0.0 0.2 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.4 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 0.5 GO:0005922 connexon complex(GO:0005922)
0.0 0.8 GO:0030125 clathrin vesicle coat(GO:0030125)
0.0 1.1 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.2 GO:0030478 actin cap(GO:0030478)
0.0 2.1 GO:0070469 respiratory chain(GO:0070469)
0.0 0.3 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 2.6 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.4 GO:0000346 transcription export complex(GO:0000346)
0.0 0.4 GO:0031083 BLOC-1 complex(GO:0031083)
0.0 0.3 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0 0.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 1.2 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.3 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 17.9 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 3.8 GO:0005911 cell-cell junction(GO:0005911)
0.0 1.2 GO:0016605 PML body(GO:0016605)
0.0 3.7 GO:0016607 nuclear speck(GO:0016607)
0.0 0.2 GO:0000930 gamma-tubulin complex(GO:0000930)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.2 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
1.5 18.1 GO:0050693 LBD domain binding(GO:0050693)
1.0 3.1 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.6 12.7 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.6 1.8 GO:0016748 succinyltransferase activity(GO:0016748)
0.5 3.7 GO:0097322 7SK snRNA binding(GO:0097322)
0.4 19.0 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.2 1.9 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.2 3.9 GO:0046625 sphingolipid binding(GO:0046625)
0.2 1.6 GO:0098821 BMP receptor activity(GO:0098821)
0.2 1.9 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.2 2.0 GO:0097109 neuroligin family protein binding(GO:0097109)
0.2 1.2 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.1 7.6 GO:1990782 protein tyrosine kinase binding(GO:1990782)
0.1 0.5 GO:0050816 phosphothreonine binding(GO:0050816)
0.1 0.4 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 0.5 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 0.3 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.1 0.2 GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.1 2.1 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 2.7 GO:0070412 R-SMAD binding(GO:0070412)
0.1 3.5 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 5.0 GO:0008276 protein methyltransferase activity(GO:0008276)
0.1 0.4 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.1 1.5 GO:0001223 transcription coactivator binding(GO:0001223)
0.1 1.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 0.2 GO:0034056 estrogen response element binding(GO:0034056)
0.1 7.7 GO:0030674 protein binding, bridging(GO:0030674)
0.1 0.2 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.1 1.6 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 0.2 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.0 0.2 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.0 0.9 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 0.8 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.7 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 1.2 GO:0050681 androgen receptor binding(GO:0050681)
0.0 17.5 GO:0005509 calcium ion binding(GO:0005509)
0.0 1.2 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 4.1 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.0 0.5 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 2.2 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.4 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 1.6 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 2.6 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 4.8 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 0.9 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 19.0 PID_ARF6_PATHWAY Arf6 signaling events
0.4 6.2 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.2 7.6 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 2.6 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.1 1.5 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 1.2 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 1.9 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 1.5 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 2.2 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 1.6 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 4.9 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.6 PID_BMP_PATHWAY BMP receptor signaling
0.0 2.0 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 0.4 PID_S1P_S1P3_PATHWAY S1P3 pathway
0.0 0.2 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.9 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.6 PID_CDC42_PATHWAY CDC42 signaling events
0.0 0.5 PID_MYC_PATHWAY C-MYC pathway
0.0 0.9 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.9 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.6 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.3 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 7.6 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.3 12.7 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 18.7 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 3.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 1.9 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1 1.6 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 1.9 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 2.2 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 1.5 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.4 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.0 0.4 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.4 REACTOME_REGULATORY_RNA_PATHWAYS Genes involved in Regulatory RNA pathways
0.0 0.5 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis