Motif ID: Spic

Z-value: 0.721


Transcription factors associated with Spic:

Gene SymbolEntrez IDGene Name
Spic ENSMUSG00000004359.10 Spic

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Spicmm10_v2_chr10_-_88683021_886830250.105.4e-01Click!


Activity profile for motif Spic.

activity profile for motif Spic


Sorted Z-values histogram for motif Spic

Sorted Z-values for motif Spic



Network of associatons between targets according to the STRING database.



First level regulatory network of Spic

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_136892867 3.008 ENSMUST00000046332.5
C1qc
complement component 1, q subcomponent, C chain
chr1_-_56978534 2.685 ENSMUST00000177282.1
Satb2
special AT-rich sequence binding protein 2
chr4_-_136886187 2.199 ENSMUST00000046384.8
C1qb
complement component 1, q subcomponent, beta polypeptide
chr11_+_78324200 2.185 ENSMUST00000102478.3
Aldoc
aldolase C, fructose-bisphosphate
chr11_-_106715251 2.163 ENSMUST00000080853.4
ENSMUST00000183610.1
ENSMUST00000103069.3
ENSMUST00000106796.2
Pecam1



platelet/endothelial cell adhesion molecule 1



chr4_-_118489755 2.140 ENSMUST00000184261.1
Tie1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr8_-_122432924 1.826 ENSMUST00000017604.8
Cyba
cytochrome b-245, alpha polypeptide
chr12_+_75308308 1.751 ENSMUST00000118602.1
ENSMUST00000118966.1
ENSMUST00000055390.5
Rhoj


ras homolog gene family, member J


chr14_+_80000292 1.718 ENSMUST00000088735.3
Olfm4
olfactomedin 4
chr4_+_130913120 1.664 ENSMUST00000151698.1
Laptm5
lysosomal-associated protein transmembrane 5
chr15_-_66812593 1.569 ENSMUST00000100572.3
Sla
src-like adaptor
chr6_+_5725639 1.553 ENSMUST00000115556.1
ENSMUST00000115555.1
ENSMUST00000115559.3
Dync1i1


dynein cytoplasmic 1 intermediate chain 1


chr17_-_25785533 1.529 ENSMUST00000140738.1
ENSMUST00000145053.1
ENSMUST00000138759.1
ENSMUST00000133071.1
ENSMUST00000077938.3
Haghl




hydroxyacylglutathione hydrolase-like




chrX_+_8271133 1.497 ENSMUST00000127103.1
ENSMUST00000115591.1
Slc38a5

solute carrier family 38, member 5

chr4_+_130913264 1.421 ENSMUST00000156225.1
ENSMUST00000156742.1
Laptm5

lysosomal-associated protein transmembrane 5

chr19_+_4231899 1.304 ENSMUST00000025773.3
Pold4
polymerase (DNA-directed), delta 4
chr6_-_48708206 1.267 ENSMUST00000119315.1
ENSMUST00000053661.4
Gimap6

GTPase, IMAP family member 6

chr12_-_4592927 1.214 ENSMUST00000170816.1
Gm3625
predicted gene 3625
chr3_+_95526777 1.211 ENSMUST00000015667.2
ENSMUST00000116304.2
Ctss

cathepsin S

chr17_-_25785324 1.177 ENSMUST00000150324.1
Haghl
hydroxyacylglutathione hydrolase-like
chr1_-_171234290 1.152 ENSMUST00000079957.6
Fcer1g
Fc receptor, IgE, high affinity I, gamma polypeptide
chr7_+_28833975 1.140 ENSMUST00000066723.8
Lgals4
lectin, galactose binding, soluble 4
chr8_+_84701430 1.128 ENSMUST00000037165.4
Lyl1
lymphoblastomic leukemia 1
chr6_+_125215551 1.109 ENSMUST00000032487.7
ENSMUST00000100942.2
ENSMUST00000063588.8
Vamp1


vesicle-associated membrane protein 1


chr2_-_91070180 1.066 ENSMUST00000153367.1
ENSMUST00000079976.3
Slc39a13

solute carrier family 39 (metal ion transporter), member 13

chr7_-_25658726 1.065 ENSMUST00000071329.6
Bckdha
branched chain ketoacid dehydrogenase E1, alpha polypeptide
chr10_+_112271123 1.001 ENSMUST00000092175.2
Kcnc2
potassium voltage gated channel, Shaw-related subfamily, member 2
chr14_+_57524734 0.996 ENSMUST00000089494.4
Il17d
interleukin 17D
chr2_-_91070283 0.988 ENSMUST00000111436.2
ENSMUST00000073575.5
Slc39a13

solute carrier family 39 (metal ion transporter), member 13

chr7_+_126695942 0.979 ENSMUST00000106369.1
Bola2
bolA-like 2 (E. coli)
chr8_-_70897407 0.885 ENSMUST00000054220.8
Rpl18a
ribosomal protein L18A
chr17_-_33955658 0.876 ENSMUST00000174609.2
ENSMUST00000008812.7
Rps18

ribosomal protein S18

chr11_+_102836296 0.848 ENSMUST00000021302.8
ENSMUST00000107072.1
Higd1b

HIG1 domain family, member 1B

chr16_+_77846693 0.845 ENSMUST00000169531.1
Gm17333
predicted gene, 17333
chr9_-_116175318 0.823 ENSMUST00000061101.4
ENSMUST00000035014.6
Tgfbr2

transforming growth factor, beta receptor II

chr2_-_167492826 0.818 ENSMUST00000109211.2
ENSMUST00000057627.9
Spata2

spermatogenesis associated 2

chr11_-_69662625 0.802 ENSMUST00000018905.5
Mpdu1
mannose-P-dolichol utilization defect 1
chr7_+_25659153 0.791 ENSMUST00000079634.6
Exosc5
exosome component 5
chr10_+_80292453 0.789 ENSMUST00000068408.7
ENSMUST00000062674.6
Rps15

ribosomal protein S15

chr11_-_113565740 0.782 ENSMUST00000071539.3
ENSMUST00000106633.3
ENSMUST00000042657.9
ENSMUST00000149034.1
Slc39a11



solute carrier family 39 (metal ion transporter), member 11



chr3_-_106790143 0.775 ENSMUST00000038845.8
Cd53
CD53 antigen
chr10_+_112172540 0.770 ENSMUST00000132994.1
Caps2
calcyphosphine 2
chr11_-_69662564 0.770 ENSMUST00000129224.1
ENSMUST00000155200.1
Mpdu1

mannose-P-dolichol utilization defect 1

chr4_-_147936713 0.756 ENSMUST00000105712.1
ENSMUST00000019199.7
Plod1

procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1

chr11_-_96916448 0.743 ENSMUST00000103152.4
Cdk5rap3
CDK5 regulatory subunit associated protein 3
chr1_-_171294937 0.733 ENSMUST00000111302.3
ENSMUST00000080001.2
Ufc1

ubiquitin-fold modifier conjugating enzyme 1

chr10_-_83648713 0.728 ENSMUST00000020500.7
Appl2
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
chr19_+_6306456 0.699 ENSMUST00000025681.7
Cdc42bpg
CDC42 binding protein kinase gamma (DMPK-like)
chr4_-_133277730 0.692 ENSMUST00000105907.2
Tmem222
transmembrane protein 222
chr4_-_40722307 0.690 ENSMUST00000181475.1
Gm6297
predicted gene 6297
chr9_-_119977250 0.685 ENSMUST00000035101.7
Csrnp1
cysteine-serine-rich nuclear protein 1
chr6_-_142702259 0.679 ENSMUST00000073173.5
ENSMUST00000111771.1
ENSMUST00000087527.4
ENSMUST00000100827.2
Abcc9



ATP-binding cassette, sub-family C (CFTR/MRP), member 9



chr10_-_30655859 0.670 ENSMUST00000092610.4
Ncoa7
nuclear receptor coactivator 7
chr2_-_130424242 0.669 ENSMUST00000089581.4
Pced1a
PC-esterase domain containing 1A
chr1_-_150393024 0.667 ENSMUST00000097546.2
ENSMUST00000111913.2
BC003331

cDNA sequence BC003331

chr5_-_110839575 0.666 ENSMUST00000145318.1
Hscb
HscB iron-sulfur cluster co-chaperone homolog (E. coli)
chr13_-_8038106 0.652 ENSMUST00000165220.2
Gm9742
predicted gene 9742
chr19_-_6909599 0.652 ENSMUST00000173091.1
Prdx5
peroxiredoxin 5
chr10_-_117282262 0.652 ENSMUST00000092163.7
Lyz2
lysozyme 2
chr2_-_148045891 0.644 ENSMUST00000109964.1
Foxa2
forkhead box A2
chr7_-_126695731 0.644 ENSMUST00000144897.1
Slx1b
SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)
chr19_-_6084941 0.636 ENSMUST00000025707.2
ENSMUST00000160712.1
Zfpl1

zinc finger like protein 1

chr16_+_91406235 0.634 ENSMUST00000023691.5
Il10rb
interleukin 10 receptor, beta
chr4_-_117887292 0.634 ENSMUST00000150204.1
ENSMUST00000147845.1
ENSMUST00000036380.7
ENSMUST00000136596.1
Atp6v0b



ATPase, H+ transporting, lysosomal V0 subunit B



chr19_-_6910088 0.627 ENSMUST00000025904.5
Prdx5
peroxiredoxin 5
chr19_-_45591820 0.620 ENSMUST00000160003.1
ENSMUST00000162879.1
Fbxw4

F-box and WD-40 domain protein 4

chr5_-_116024452 0.618 ENSMUST00000031486.7
Prkab1
protein kinase, AMP-activated, beta 1 non-catalytic subunit
chr15_+_78877172 0.615 ENSMUST00000041587.7
Gga1
golgi associated, gamma adaptin ear containing, ARF binding protein 1
chr10_+_58255465 0.614 ENSMUST00000057659.7
ENSMUST00000162041.1
ENSMUST00000162860.1
Gcc2


GRIP and coiled-coil domain containing 2


chr12_+_84361636 0.609 ENSMUST00000110276.1
Coq6
coenzyme Q6 homolog (yeast)
chr7_-_19604444 0.608 ENSMUST00000086041.5
Clasrp
CLK4-associating serine/arginine rich protein
chr1_+_87620334 0.604 ENSMUST00000042275.8
ENSMUST00000168783.1
Inpp5d

inositol polyphosphate-5-phosphatase D

chr4_+_138775735 0.598 ENSMUST00000030528.2
Pla2g2d
phospholipase A2, group IID
chrX_-_21061981 0.595 ENSMUST00000040628.5
ENSMUST00000115333.2
ENSMUST00000115334.1
Zfp182


zinc finger protein 182


chr11_-_103344651 0.589 ENSMUST00000041385.7
Arhgap27
Rho GTPase activating protein 27
chr1_+_171840607 0.585 ENSMUST00000136479.1
ENSMUST00000042302.6
Cd84

CD84 antigen

chr1_+_72711259 0.585 ENSMUST00000059980.9
Rpl37a
ribosomal protein L37a
chr17_-_47688028 0.584 ENSMUST00000113301.1
ENSMUST00000113302.3
Tomm6

translocase of outer mitochondrial membrane 6 homolog (yeast)

chr12_+_4592992 0.583 ENSMUST00000062580.7
Itsn2
intersectin 2
chr11_-_102469839 0.579 ENSMUST00000103086.3
Itga2b
integrin alpha 2b
chr7_-_90129339 0.578 ENSMUST00000181189.1
2310010J17Rik
RIKEN cDNA 2310010J17 gene
chr11_+_70540260 0.577 ENSMUST00000018429.5
ENSMUST00000108557.3
ENSMUST00000108556.1
Pld2


phospholipase D2


chr8_-_85080679 0.576 ENSMUST00000093357.5
Wdr83
WD repeat domain containing 83
chr11_-_120151194 0.569 ENSMUST00000179094.1
ENSMUST00000103018.4
ENSMUST00000045402.7
ENSMUST00000076697.6
ENSMUST00000053692.8
Slc38a10




solute carrier family 38, member 10




chr8_+_85080939 0.566 ENSMUST00000140621.1
BC056474
cDNA sequence BC056474
chr5_+_44966583 0.555 ENSMUST00000079389.5
4930431F12Rik
RIKEN cDNA 4930431F12 gene
chr1_-_150392719 0.551 ENSMUST00000006167.6
ENSMUST00000094477.2
ENSMUST00000097547.3
BC003331


cDNA sequence BC003331


chr11_-_50431101 0.551 ENSMUST00000020643.3
Rufy1
RUN and FYVE domain containing 1
chr1_-_165934900 0.550 ENSMUST00000069609.5
ENSMUST00000111427.2
ENSMUST00000111426.4
Pou2f1


POU domain, class 2, transcription factor 1


chr3_+_95499273 0.548 ENSMUST00000015664.3
Ctsk
cathepsin K
chr2_+_180257373 0.545 ENSMUST00000059080.6
Rps21
ribosomal protein S21
chr17_-_29347902 0.542 ENSMUST00000095427.4
ENSMUST00000118366.1
Mtch1

mitochondrial carrier homolog 1 (C. elegans)

chr7_+_44857309 0.538 ENSMUST00000098478.3
Pnkp
polynucleotide kinase 3'- phosphatase
chr19_+_6941861 0.533 ENSMUST00000025910.5
Bad
BCL2-associated agonist of cell death
chr11_-_5837760 0.530 ENSMUST00000109837.1
Polm
polymerase (DNA directed), mu
chr4_+_11758147 0.530 ENSMUST00000029871.5
ENSMUST00000108303.1
Cdh17

cadherin 17

chr12_+_84361968 0.528 ENSMUST00000021661.6
Coq6
coenzyme Q6 homolog (yeast)
chr8_-_85080652 0.522 ENSMUST00000152785.1
Wdr83
WD repeat domain containing 83
chr7_-_79743034 0.522 ENSMUST00000032761.7
Pex11a
peroxisomal biogenesis factor 11 alpha
chr11_-_11627824 0.521 ENSMUST00000081896.4
4930512M02Rik
RIKEN cDNA 4930512M02 gene
chr11_+_114851142 0.518 ENSMUST00000133245.1
ENSMUST00000122967.2
Gprc5c

G protein-coupled receptor, family C, group 5, member C

chrX_+_107255878 0.517 ENSMUST00000101294.2
ENSMUST00000118820.1
ENSMUST00000120971.1
Gpr174


G protein-coupled receptor 174


chr7_+_105640522 0.510 ENSMUST00000106785.1
ENSMUST00000106786.1
ENSMUST00000106780.1
ENSMUST00000106784.1
Timm10b



translocase of inner mitochondrial membrane 10B



chr2_+_36230426 0.508 ENSMUST00000062069.5
Ptgs1
prostaglandin-endoperoxide synthase 1
chr9_+_58253164 0.501 ENSMUST00000034883.5
Stoml1
stomatin-like 1
chr1_-_171059390 0.501 ENSMUST00000164044.1
ENSMUST00000169017.1
Fcgr3

Fc receptor, IgG, low affinity III

chr2_-_25319095 0.496 ENSMUST00000114318.3
ENSMUST00000114310.3
ENSMUST00000114308.3
ENSMUST00000114317.3
ENSMUST00000028335.6
ENSMUST00000114314.3
ENSMUST00000114307.1
Grin1






glutamate receptor, ionotropic, NMDA1 (zeta 1)






chr13_+_98263187 0.495 ENSMUST00000091356.3
ENSMUST00000123924.1
Ankra2

ankyrin repeat, family A (RFXANK-like), 2

chr11_-_96916366 0.494 ENSMUST00000144731.1
ENSMUST00000127048.1
Cdk5rap3

CDK5 regulatory subunit associated protein 3

chr15_-_80264276 0.492 ENSMUST00000052499.7
Rps19bp1
ribosomal protein S19 binding protein 1
chr13_-_38960498 0.476 ENSMUST00000167513.1
Slc35b3
solute carrier family 35, member B3
chr6_-_136941887 0.471 ENSMUST00000111891.1
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr15_-_89128634 0.470 ENSMUST00000082197.5
Hdac10
histone deacetylase 10
chr19_+_8871512 0.468 ENSMUST00000166407.1
Ubxn1
UBX domain protein 1
chr2_+_130424321 0.467 ENSMUST00000128994.1
ENSMUST00000028900.9
Vps16

vacuolar protein sorting 16 (yeast)

chr4_+_129335593 0.465 ENSMUST00000141235.1
Zbtb8os
zinc finger and BTB domain containing 8 opposite strand
chr16_+_32419696 0.463 ENSMUST00000014220.8
ENSMUST00000080316.7
Tctex1d2

Tctex1 domain containing 2

chr8_+_66386292 0.461 ENSMUST00000039540.5
ENSMUST00000110253.2
March1

membrane-associated ring finger (C3HC4) 1

chr2_-_130424673 0.455 ENSMUST00000110277.1
Pced1a
PC-esterase domain containing 1A
chr13_-_90089513 0.452 ENSMUST00000160232.1
Xrcc4
X-ray repair complementing defective repair in Chinese hamster cells 4
chr19_+_18631927 0.446 ENSMUST00000159572.1
ENSMUST00000042392.7
Nmrk1

nicotinamide riboside kinase 1

chr12_+_84362029 0.446 ENSMUST00000110278.1
ENSMUST00000145522.1
Coq6

coenzyme Q6 homolog (yeast)

chr1_+_155158703 0.446 ENSMUST00000027743.7
Stx6
syntaxin 6
chr1_-_179546261 0.445 ENSMUST00000027769.5
Tfb2m
transcription factor B2, mitochondrial
chr4_-_124850670 0.444 ENSMUST00000163946.1
ENSMUST00000106190.3
1110065P20Rik

RIKEN cDNA 1110065P20 gene

chr7_+_44857137 0.443 ENSMUST00000107876.1
ENSMUST00000003044.7
ENSMUST00000154968.1
Pnkp


polynucleotide kinase 3'- phosphatase


chr6_-_83121385 0.442 ENSMUST00000146328.1
ENSMUST00000113936.3
ENSMUST00000032111.4
Wbp1


WW domain binding protein 1


chr6_-_72362382 0.437 ENSMUST00000114095.1
ENSMUST00000069595.6
ENSMUST00000069580.5
Rnf181


ring finger protein 181


chr11_+_49609263 0.433 ENSMUST00000020617.2
Flt4
FMS-like tyrosine kinase 4
chr5_+_136962077 0.433 ENSMUST00000019198.6
Fis1
fission 1 (mitochondrial outer membrane) homolog (yeast)
chr4_-_117887279 0.430 ENSMUST00000132073.1
Atp6v0b
ATPase, H+ transporting, lysosomal V0 subunit B
chr13_-_58128542 0.429 ENSMUST00000007980.6
Hnrnpa0
heterogeneous nuclear ribonucleoprotein A0
chr11_-_96916407 0.426 ENSMUST00000130774.1
Cdk5rap3
CDK5 regulatory subunit associated protein 3
chr5_-_116024475 0.424 ENSMUST00000111999.1
Prkab1
protein kinase, AMP-activated, beta 1 non-catalytic subunit
chr7_-_105640308 0.420 ENSMUST00000133519.1
ENSMUST00000084782.2
ENSMUST00000131446.1
Arfip2


ADP-ribosylation factor interacting protein 2


chr6_+_17749170 0.412 ENSMUST00000053148.7
ENSMUST00000115417.3
St7

suppression of tumorigenicity 7

chr19_-_6084873 0.411 ENSMUST00000160977.1
ENSMUST00000159859.1
Zfpl1

zinc finger like protein 1

chr11_+_69914179 0.408 ENSMUST00000057884.5
Gps2
G protein pathway suppressor 2
chr8_+_107056870 0.408 ENSMUST00000034392.5
ENSMUST00000170962.1
Nip7

nuclear import 7 homolog (S. cerevisiae)

chr17_+_29268788 0.408 ENSMUST00000064709.5
ENSMUST00000120346.1
BC004004

cDNA sequence BC004004

chr8_+_123102344 0.408 ENSMUST00000000756.5
Rpl13
ribosomal protein L13
chr13_-_38960846 0.407 ENSMUST00000021870.4
Slc35b3
solute carrier family 35, member B3
chr19_-_6084679 0.405 ENSMUST00000161548.1
Zfpl1
zinc finger like protein 1
chr11_-_97782409 0.402 ENSMUST00000103146.4
Rpl23
ribosomal protein L23
chr11_+_78176711 0.397 ENSMUST00000098545.5
Tlcd1
TLC domain containing 1
chr5_-_3893907 0.394 ENSMUST00000117463.1
ENSMUST00000044746.4
Mterf

mitochondrial transcription termination factor

chr4_-_86857365 0.393 ENSMUST00000102814.4
Rps6
ribosomal protein S6
chr6_+_113604749 0.392 ENSMUST00000035725.5
Brk1
BRICK1, SCAR/WAVE actin-nucleating complex subunit
chr7_+_105640448 0.391 ENSMUST00000058333.3
Timm10b
translocase of inner mitochondrial membrane 10B
chr9_+_20644792 0.382 ENSMUST00000162303.1
ENSMUST00000161486.1
Ubl5

ubiquitin-like 5

chr5_+_34999111 0.381 ENSMUST00000114283.1
Rgs12
regulator of G-protein signaling 12
chr7_-_16286744 0.377 ENSMUST00000150528.2
ENSMUST00000118976.2
ENSMUST00000146609.2
Ccdc9


coiled-coil domain containing 9


chr4_+_115839192 0.375 ENSMUST00000019677.5
ENSMUST00000144427.1
ENSMUST00000106513.3
ENSMUST00000130819.1
ENSMUST00000151203.1
ENSMUST00000140315.1
Mknk1





MAP kinase-interacting serine/threonine kinase 1





chr19_+_8871636 0.375 ENSMUST00000096255.5
Ubxn1
UBX domain protein 1
chr16_+_13903152 0.374 ENSMUST00000128757.1
Mpv17l
Mpv17 transgene, kidney disease mutant-like
chr1_+_74771886 0.372 ENSMUST00000006716.6
Wnt6
wingless-related MMTV integration site 6
chr1_+_17601893 0.372 ENSMUST00000088476.2
Pi15
peptidase inhibitor 15
chr7_+_122133036 0.371 ENSMUST00000033156.4
Dctn5
dynactin 5
chrX_+_48623737 0.367 ENSMUST00000114936.1
Slc25a14
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr4_-_154160632 0.357 ENSMUST00000105639.3
ENSMUST00000030896.8
Tprgl

transformation related protein 63 regulated like

chr13_+_98263242 0.355 ENSMUST00000022164.8
ENSMUST00000150352.1
Ankra2

ankyrin repeat, family A (RFXANK-like), 2

chr5_+_34999046 0.353 ENSMUST00000114281.1
Rgs12
regulator of G-protein signaling 12
chr2_+_156840966 0.350 ENSMUST00000109564.1
Tgif2
TGFB-induced factor homeobox 2
chr7_+_126695355 0.349 ENSMUST00000130498.1
Bola2
bolA-like 2 (E. coli)
chr11_-_78176619 0.349 ENSMUST00000148154.2
ENSMUST00000017549.6
Nek8

NIMA (never in mitosis gene a)-related expressed kinase 8

chr7_-_104315455 0.348 ENSMUST00000106837.1
ENSMUST00000106839.2
ENSMUST00000070943.6
Trim12a


tripartite motif-containing 12A


chr7_-_5413145 0.344 ENSMUST00000108569.2
Vmn1r58
vomeronasal 1 receptor 58
chr17_+_34850373 0.343 ENSMUST00000097343.4
ENSMUST00000173357.1
ENSMUST00000173065.1
ENSMUST00000165953.2
Nelfe



negative elongation factor complex member E, Rdbp



chr12_+_11265867 0.340 ENSMUST00000020931.5
Smc6
structural maintenance of chromosomes 6
chr6_-_136941694 0.339 ENSMUST00000032344.5
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr3_-_84582476 0.336 ENSMUST00000107687.2
ENSMUST00000098990.3
Arfip1

ADP-ribosylation factor interacting protein 1

chr1_+_36307745 0.334 ENSMUST00000142319.1
ENSMUST00000097778.2
ENSMUST00000115031.1
ENSMUST00000115032.1
ENSMUST00000137906.1
ENSMUST00000115029.1
Arid5a





AT rich interactive domain 5A (MRF1-like)





chr5_+_124552845 0.329 ENSMUST00000071057.7
Ddx55
DEAD (Asp-Glu-Ala-Asp) box polypeptide 55
chr6_-_136941494 0.329 ENSMUST00000111892.1
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr7_-_100856289 0.329 ENSMUST00000139604.1
Relt
RELT tumor necrosis factor receptor
chr12_-_78980758 0.327 ENSMUST00000174072.1
Tmem229b
transmembrane protein 229B
chr16_+_35154870 0.325 ENSMUST00000114913.1
Adcy5
adenylate cyclase 5
chr16_+_36934976 0.325 ENSMUST00000023531.8
Hcls1
hematopoietic cell specific Lyn substrate 1
chr13_+_98263105 0.325 ENSMUST00000150916.1
Ankra2
ankyrin repeat, family A (RFXANK-like), 2
chr8_-_95434869 0.320 ENSMUST00000034249.6
Gtl3
gene trap locus 3
chr10_-_89732253 0.318 ENSMUST00000020109.3
Actr6
ARP6 actin-related protein 6
chr5_+_124552905 0.311 ENSMUST00000111438.1
Ddx55
DEAD (Asp-Glu-Ala-Asp) box polypeptide 55
chr15_+_76368884 0.306 ENSMUST00000023213.6
Fam203a
family with sequence similarity 203, member A
chrX_-_74023908 0.306 ENSMUST00000033769.8
ENSMUST00000114352.1
ENSMUST00000068286.5
ENSMUST00000114360.3
ENSMUST00000114354.3
Irak1




interleukin-1 receptor-associated kinase 1




chr17_+_74489492 0.305 ENSMUST00000024873.6
Yipf4
Yip1 domain family, member 4
chr9_+_20644851 0.303 ENSMUST00000161882.1
Ubl5
ubiquitin-like 5
chr5_+_114100308 0.300 ENSMUST00000031588.7
Usp30
ubiquitin specific peptidase 30
chr11_+_70130329 0.299 ENSMUST00000041550.5
ENSMUST00000165951.1
Mgl2

macrophage galactose N-acetyl-galactosamine specific lectin 2

chr1_+_150393250 0.296 ENSMUST00000119161.2
Tpr
translocated promoter region
chr14_-_68655804 0.294 ENSMUST00000111072.1
ENSMUST00000022642.5
Adam28

a disintegrin and metallopeptidase domain 28

chr6_+_48684570 0.293 ENSMUST00000067506.7
ENSMUST00000119575.1
ENSMUST00000114527.2
ENSMUST00000121957.1
ENSMUST00000090070.5
Gimap4




GTPase, IMAP family member 4




chr1_+_171895664 0.291 ENSMUST00000097466.2
Gm10521
predicted gene 10521
chr5_-_130002838 0.290 ENSMUST00000111308.1
ENSMUST00000111307.1
Gusb

glucuronidase, beta

chr19_+_6909722 0.289 ENSMUST00000116551.3
Trmt112
tRNA methyltransferase 11-2
chr1_+_150392794 0.285 ENSMUST00000124973.2
Tpr
translocated promoter region
chr5_+_145140362 0.285 ENSMUST00000162594.1
ENSMUST00000162308.1
ENSMUST00000159018.1
ENSMUST00000160075.1
Bud31



BUD31 homolog (yeast)



chr2_-_164804876 0.283 ENSMUST00000103094.4
ENSMUST00000017451.6
Acot8

acyl-CoA thioesterase 8

chr5_-_91962715 0.282 ENSMUST00000169948.1
Rchy1
ring finger and CHY zinc finger domain containing 1
chr5_-_138171216 0.282 ENSMUST00000147920.1
Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
chr3_+_7612702 0.281 ENSMUST00000181286.1
Gm16685
predicted gene, 16685

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.2 GO:0050904 diapedesis(GO:0050904)
0.5 1.5 GO:0001803 type III hypersensitivity(GO:0001802) regulation of type III hypersensitivity(GO:0001803) positive regulation of type III hypersensitivity(GO:0001805)
0.4 1.3 GO:0060785 regulation of apoptosis involved in tissue homeostasis(GO:0060785)
0.4 0.8 GO:2000157 regulation of protein K48-linked deubiquitination(GO:1903093) negative regulation of protein K48-linked deubiquitination(GO:1903094) negative regulation of ubiquitin-specific protease activity(GO:2000157)
0.4 2.7 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
0.4 1.8 GO:0033864 positive regulation of NAD(P)H oxidase activity(GO:0033864) positive regulation of toll-like receptor 2 signaling pathway(GO:0034137)
0.3 1.0 GO:0098501 polynucleotide dephosphorylation(GO:0098501)
0.3 0.8 GO:0003274 endocardial cushion fusion(GO:0003274)
0.3 0.3 GO:0016068 regulation of type I hypersensitivity(GO:0001810) type I hypersensitivity(GO:0016068)
0.3 2.7 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.3 0.8 GO:0070476 rRNA (guanine-N7)-methylation(GO:0070476)
0.3 2.3 GO:0071569 protein ufmylation(GO:0071569)
0.2 0.4 GO:0002309 T cell proliferation involved in immune response(GO:0002309)
0.2 2.2 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.2 0.7 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.2 0.6 GO:0045014 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) detection of glucose(GO:0051594)
0.2 0.6 GO:1904431 positive regulation of t-circle formation(GO:1904431)
0.2 1.0 GO:0038032 termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.2 0.6 GO:0045658 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
0.2 0.8 GO:0071051 polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.2 0.8 GO:0010700 negative regulation of norepinephrine secretion(GO:0010700)
0.2 0.6 GO:2001180 negative regulation of interleukin-18 production(GO:0032701) negative regulation of interleukin-10 secretion(GO:2001180)
0.2 0.6 GO:0032240 mRNA export from nucleus in response to heat stress(GO:0031990) negative regulation of nucleobase-containing compound transport(GO:0032240) negative regulation of RNA export from nucleus(GO:0046832)
0.2 1.1 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.2 0.8 GO:0046947 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.2 2.7 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.2 0.5 GO:1902220 positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902220)
0.2 0.5 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.2 1.0 GO:0035878 nail development(GO:0035878)
0.2 0.5 GO:1900673 olefin metabolic process(GO:1900673)
0.2 1.1 GO:0001955 blood vessel maturation(GO:0001955)
0.1 0.4 GO:1904578 response to thapsigargin(GO:1904578) cellular response to thapsigargin(GO:1904579)
0.1 1.6 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.1 1.6 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.1 0.3 GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'(GO:0034427)
0.1 1.8 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.1 0.4 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.1 0.6 GO:0072717 cellular response to actinomycin D(GO:0072717)
0.1 2.1 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.1 1.5 GO:0015816 glycine transport(GO:0015816)
0.1 1.0 GO:0051103 DNA ligation involved in DNA repair(GO:0051103)
0.1 2.2 GO:0006958 complement activation, classical pathway(GO:0006958)
0.1 0.6 GO:0071955 recycling endosome to Golgi transport(GO:0071955)
0.1 0.3 GO:0044313 protein K6-linked deubiquitination(GO:0044313)
0.1 0.7 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.1 1.7 GO:0035493 SNARE complex assembly(GO:0035493)
0.1 0.5 GO:0031125 rRNA 3'-end processing(GO:0031125)
0.1 0.5 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.1 1.4 GO:0030574 collagen catabolic process(GO:0030574)
0.1 1.6 GO:0006744 ubiquinone biosynthetic process(GO:0006744)
0.1 0.5 GO:0016557 peroxisome membrane biogenesis(GO:0016557) regulation of peroxisome size(GO:0044375)
0.1 0.3 GO:1905076 regulation of interleukin-17 secretion(GO:1905076) positive regulation of T-helper 17 type immune response(GO:2000318)
0.1 1.0 GO:1903818 positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.1 0.2 GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
0.1 0.5 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.1 0.3 GO:2000152 regulation of ubiquitin-specific protease activity(GO:2000152)
0.1 0.6 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.1 2.0 GO:0045026 plasma membrane fusion(GO:0045026)
0.1 0.2 GO:1904569 regulation of selenocysteine incorporation(GO:1904569)
0.1 0.3 GO:0016559 peroxisome fission(GO:0016559)
0.1 0.4 GO:1901727 positive regulation of histone deacetylase activity(GO:1901727)
0.1 0.2 GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045869)
0.1 0.3 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.1 1.1 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.1 0.4 GO:0010730 negative regulation of hydrogen peroxide metabolic process(GO:0010727) negative regulation of hydrogen peroxide biosynthetic process(GO:0010730)
0.1 0.2 GO:2001187 positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.1 1.3 GO:0000731 DNA synthesis involved in DNA repair(GO:0000731)
0.1 1.2 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)
0.1 0.2 GO:0048611 ectodermal digestive tract development(GO:0007439) embryonic ectodermal digestive tract development(GO:0048611)
0.1 0.2 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.1 0.7 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.1 0.4 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.1 0.5 GO:0016446 somatic hypermutation of immunoglobulin genes(GO:0016446)
0.0 0.1 GO:0090289 regulation of osteoclast proliferation(GO:0090289)
0.0 0.8 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.0 1.1 GO:0007035 vacuolar acidification(GO:0007035)
0.0 0.4 GO:0090037 positive regulation of protein kinase C signaling(GO:0090037)
0.0 0.2 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.0 0.1 GO:0035928 rRNA import into mitochondrion(GO:0035928)
0.0 0.7 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 0.3 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.0 0.5 GO:2000650 negative regulation of sodium ion transmembrane transporter activity(GO:2000650)
0.0 0.6 GO:0006829 zinc II ion transport(GO:0006829)
0.0 0.3 GO:0007195 adenosine receptor signaling pathway(GO:0001973) adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.0 1.7 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 0.2 GO:0034379 very-low-density lipoprotein particle assembly(GO:0034379)
0.0 0.5 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0 0.6 GO:0060363 cranial suture morphogenesis(GO:0060363)
0.0 0.2 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.0 0.3 GO:1900364 negative regulation of mRNA polyadenylation(GO:1900364)
0.0 0.1 GO:1901069 guanosine-containing compound catabolic process(GO:1901069)
0.0 0.3 GO:0009396 folic acid-containing compound biosynthetic process(GO:0009396)
0.0 0.2 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.0 0.2 GO:0072697 protein localization to cell cortex(GO:0072697)
0.0 0.3 GO:0035330 regulation of hippo signaling(GO:0035330)
0.0 0.2 GO:0071476 cellular hypotonic response(GO:0071476)
0.0 0.1 GO:0017185 peptidyl-lysine hydroxylation(GO:0017185)
0.0 0.4 GO:0090161 Golgi ribbon formation(GO:0090161)
0.0 0.1 GO:1904809 dense core granule localization(GO:0032253) dense core granule transport(GO:1901950) regulation of dense core granule transport(GO:1904809) positive regulation of dense core granule transport(GO:1904811)
0.0 0.4 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0 0.6 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 0.2 GO:0033008 positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of mast cell degranulation(GO:0043306)
0.0 0.5 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0 0.5 GO:0000338 protein deneddylation(GO:0000338)
0.0 0.1 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 0.3 GO:0031145 anaphase-promoting complex-dependent catabolic process(GO:0031145)
0.0 0.3 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 0.1 GO:0006742 NADP catabolic process(GO:0006742) pyridine nucleotide catabolic process(GO:0019364)
0.0 1.6 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 0.1 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406)
0.0 0.3 GO:0019363 pyridine nucleotide biosynthetic process(GO:0019363)
0.0 0.2 GO:0061002 negative regulation of dendritic spine morphogenesis(GO:0061002)
0.0 0.1 GO:0006983 ER overload response(GO:0006983)
0.0 0.1 GO:0090024 negative regulation of granulocyte chemotaxis(GO:0071623) negative regulation of neutrophil chemotaxis(GO:0090024)
0.0 0.2 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.0 0.4 GO:0038092 nodal signaling pathway(GO:0038092)
0.0 0.6 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.1 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0 0.0 GO:0090400 stress-induced premature senescence(GO:0090400)
0.0 0.3 GO:0006298 mismatch repair(GO:0006298)
0.0 0.6 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.2 GO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesis(GO:0003413)
0.0 0.7 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.7 GO:1901998 toxin transport(GO:1901998)
0.0 0.1 GO:0006788 heme oxidation(GO:0006788)
0.0 0.3 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 2.2 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.0 0.3 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.0 0.1 GO:0006544 glycine metabolic process(GO:0006544)
0.0 0.2 GO:0016486 peptide hormone processing(GO:0016486)
0.0 0.1 GO:0006013 mannose metabolic process(GO:0006013)
0.0 0.1 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.0 0.2 GO:0045116 protein neddylation(GO:0045116)
0.0 1.5 GO:0051607 defense response to virus(GO:0051607)
0.0 0.4 GO:0046329 negative regulation of JNK cascade(GO:0046329)
0.0 0.1 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.0 0.0 GO:0043651 linoleic acid metabolic process(GO:0043651)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:1990257 piccolo-bassoon transport vesicle(GO:1990257)
0.4 1.3 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.4 2.2 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.4 1.9 GO:0043020 NADPH oxidase complex(GO:0043020)
0.3 1.1 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.2 1.2 GO:0070820 tertiary granule(GO:0070820)
0.2 1.2 GO:1990393 3M complex(GO:1990393)
0.2 0.9 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.2 0.7 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.2 1.0 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) DNA ligase IV complex(GO:0032807)
0.2 1.7 GO:0042581 specific granule(GO:0042581)
0.2 1.1 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.1 0.7 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.1 0.5 GO:0044307 dendritic branch(GO:0044307)
0.1 0.3 GO:0097543 ciliary inversin compartment(GO:0097543)
0.1 0.3 GO:0035061 interchromatin granule(GO:0035061)
0.1 0.3 GO:0099631 postsynaptic endocytic zone cytoplasmic component(GO:0099631)
0.1 0.6 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.1 0.5 GO:0031021 interphase microtubule organizing center(GO:0031021)
0.1 0.3 GO:0055087 Ski complex(GO:0055087)
0.1 0.2 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 5.4 GO:0005581 collagen trimer(GO:0005581)
0.1 0.6 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 0.8 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.1 0.5 GO:0033263 CORVET complex(GO:0033263)
0.1 1.0 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 0.6 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 0.8 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 1.6 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 3.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 0.2 GO:0032021 NELF complex(GO:0032021)
0.1 0.2 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.1 0.2 GO:0098888 extrinsic component of presynaptic membrane(GO:0098888)
0.0 0.5 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 0.3 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.2 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0 0.5 GO:0031209 SCAR complex(GO:0031209)
0.0 0.1 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.2 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 0.1 GO:0097651 phosphatidylinositol 3-kinase complex, class I(GO:0097651)
0.0 0.2 GO:1990745 EARP complex(GO:1990745)
0.0 0.3 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.0 2.4 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.0 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.0 0.4 GO:0005869 dynactin complex(GO:0005869)
0.0 0.3 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 1.0 GO:0030673 axolemma(GO:0030673)
0.0 0.2 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.2 GO:0034709 methylosome(GO:0034709)
0.0 2.4 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.6 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.6 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.8 GO:0097440 apical dendrite(GO:0097440)
0.0 0.9 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.3 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.6 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.3 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.3 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.2 GO:0002080 acrosomal membrane(GO:0002080)
0.0 1.6 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 0.0 GO:0070985 TFIIK complex(GO:0070985)
0.0 1.3 GO:0005901 caveola(GO:0005901)
0.0 0.5 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 0.1 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.3 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.2 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 0.5 GO:0008180 COP9 signalosome(GO:0008180)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.9 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.4 1.3 GO:0072541 peroxynitrite reductase activity(GO:0072541)
0.4 2.2 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.3 2.7 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.3 1.8 GO:0019864 immunoglobulin receptor activity(GO:0019763) IgG binding(GO:0019864)
0.3 0.9 GO:0046964 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity(GO:0046964)
0.2 0.7 GO:0071568 UFM1 transferase activity(GO:0071568)
0.2 0.7 GO:0003796 lysozyme activity(GO:0003796)
0.2 0.8 GO:0036435 K48-linked polyubiquitin binding(GO:0036435)
0.2 0.8 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.2 1.0 GO:0046403 polynucleotide 3'-phosphatase activity(GO:0046403)
0.2 0.8 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.2 0.5 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.2 0.5 GO:0005118 sevenless binding(GO:0005118)
0.2 1.1 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.2 1.0 GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599)
0.1 1.5 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.1 1.2 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.1 0.8 GO:0016936 galactoside binding(GO:0016936)
0.1 0.6 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.1 0.6 GO:0051425 PTB domain binding(GO:0051425)
0.1 0.6 GO:0070051 fibrinogen binding(GO:0070051)
0.1 0.4 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.1 0.6 GO:0004920 interleukin-10 receptor activity(GO:0004920)
0.1 2.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 1.0 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.1 0.3 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.1 1.1 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.1 1.7 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.1 1.6 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 1.1 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 0.8 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.1 0.5 GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.1 0.2 GO:1990955 G-rich single-stranded DNA binding(GO:1990955)
0.1 1.8 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.1 0.2 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.1 0.2 GO:0016901 glycerol-3-phosphate dehydrogenase activity(GO:0004368) oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
0.1 0.5 GO:0016248 ion channel inhibitor activity(GO:0008200) channel inhibitor activity(GO:0016248)
0.1 1.7 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 0.4 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.1 0.2 GO:1904288 BAT3 complex binding(GO:1904288)
0.1 2.0 GO:0043394 proteoglycan binding(GO:0043394)
0.1 0.2 GO:0004660 protein farnesyltransferase activity(GO:0004660)
0.1 0.6 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.1 1.0 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 0.3 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.1 0.7 GO:0031386 protein tag(GO:0031386)
0.0 0.5 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0 1.7 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.3 GO:0045322 unmethylated CpG binding(GO:0045322)
0.0 0.3 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.2 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
0.0 0.4 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 1.2 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.0 0.5 GO:0045125 bioactive lipid receptor activity(GO:0045125)
0.0 2.1 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0 1.4 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 1.0 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.2 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.0 4.8 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.3 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 0.2 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 0.1 GO:0004875 complement receptor activity(GO:0004875)
0.0 0.1 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 0.1 GO:0008517 folic acid transporter activity(GO:0008517)
0.0 0.8 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.2 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.6 GO:0070840 dynein complex binding(GO:0070840)
0.0 0.5 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.3 GO:0042288 MHC class I protein binding(GO:0042288)
0.0 0.2 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 0.5 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 0.1 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.2 GO:0034711 inhibin binding(GO:0034711)
0.0 0.3 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.3 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 0.3 GO:0035613 RNA stem-loop binding(GO:0035613)
0.0 0.3 GO:0005542 folic acid binding(GO:0005542)
0.0 0.3 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.1 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.0 0.2 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.4 GO:0050699 WW domain binding(GO:0050699)
0.0 0.6 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 1.0 GO:0019905 syntaxin binding(GO:0019905)
0.0 0.5 GO:0004601 peroxidase activity(GO:0004601)
0.0 0.7 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.4 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 0.4 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.1 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.2 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.4 GO:0005109 frizzled binding(GO:0005109)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.5 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 3.7 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.0 5.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.4 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 1.9 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 0.2 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 2.5 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.5 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.2 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.0 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 1.2 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 0.2 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 1.2 PID_VEGFR1_2_PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.3 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 1.7 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.0 0.4 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.0 1.0 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 0.2 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.4 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.0 0.3 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.0 1.1 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.3 PID_ARF_3PATHWAY Arf1 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 5.2 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.4 1.2 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.2 1.6 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.1 2.0 REACTOME_PECAM1_INTERACTIONS Genes involved in PECAM1 interactions
0.1 1.6 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 1.2 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 3.2 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.1 1.0 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1 0.8 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.1 0.6 REACTOME_ACYL_CHAIN_REMODELLING_OF_PI Genes involved in Acyl chain remodelling of PI
0.1 0.5 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR
0.1 0.6 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.1 1.0 REACTOME_INTEGRATION_OF_PROVIRUS Genes involved in Integration of provirus
0.1 2.2 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 0.5 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 5.5 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.0 1.1 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.5 REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 1.5 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.8 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.4 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.5 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 0.4 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.5 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 0.3 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.6 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 1.0 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.3 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.0 0.5 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 0.5 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.2 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.6 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 1.0 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.3 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.0 0.3 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.4 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.3 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 1.2 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.6 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.3 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 0.2 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.2 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation