Motif ID: Runx3

Z-value: 0.580


Transcription factors associated with Runx3:

Gene SymbolEntrez IDGene Name
Runx3 ENSMUSG00000070691.4 Runx3



Activity profile for motif Runx3.

activity profile for motif Runx3


Sorted Z-values histogram for motif Runx3

Sorted Z-values for motif Runx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Runx3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_-_20181773 5.800 ENSMUST00000024011.8
Kcnk5
potassium channel, subfamily K, member 5
chr2_-_71546745 3.659 ENSMUST00000024159.6
Dlx2
distal-less homeobox 2
chr11_-_89302545 3.367 ENSMUST00000061728.3
Nog
noggin
chr13_-_22041352 3.216 ENSMUST00000102977.2
Hist1h4i
histone cluster 1, H4i
chr3_-_154330543 2.746 ENSMUST00000184966.1
ENSMUST00000177846.2
Lhx8

LIM homeobox protein 8

chr13_-_23551648 2.265 ENSMUST00000102971.1
Hist1h4f
histone cluster 1, H4f
chr13_-_23698454 2.017 ENSMUST00000102967.1
Hist1h4c
histone cluster 1, H4c
chr18_-_47368446 1.830 ENSMUST00000076043.6
ENSMUST00000135790.1
Sema6a

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

chr17_+_27556668 1.814 ENSMUST00000117254.1
ENSMUST00000118570.1
Hmga1

high mobility group AT-hook 1

chr17_+_27556613 1.755 ENSMUST00000117600.1
ENSMUST00000114888.3
Hmga1

high mobility group AT-hook 1

chrX_+_99136119 1.749 ENSMUST00000052839.6
Efnb1
ephrin B1
chr17_+_27556641 1.725 ENSMUST00000119486.1
ENSMUST00000118599.1
Hmga1

high mobility group AT-hook 1

chr13_+_51645232 1.718 ENSMUST00000075853.5
Cks2
CDC28 protein kinase regulatory subunit 2
chr13_-_21832194 1.666 ENSMUST00000102979.1
Hist1h4n
histone cluster 1, H4n
chr7_-_78783026 1.563 ENSMUST00000032841.5
Mrpl46
mitochondrial ribosomal protein L46
chr7_+_141216626 1.534 ENSMUST00000141804.1
ENSMUST00000148975.1
Rassf7

Ras association (RalGDS/AF-6) domain family (N-terminal) member 7

chr11_-_5878207 1.356 ENSMUST00000102922.3
Pold2
polymerase (DNA directed), delta 2, regulatory subunit
chr19_-_36736653 1.289 ENSMUST00000087321.2
Ppp1r3c
protein phosphatase 1, regulatory (inhibitor) subunit 3C
chr13_+_21735055 1.246 ENSMUST00000087714.4
Hist1h4j
histone cluster 1, H4j
chr17_+_30005029 1.149 ENSMUST00000057897.7
Zfand3
zinc finger, AN1-type domain 3
chr2_+_72476225 1.147 ENSMUST00000157019.1
Cdca7
cell division cycle associated 7
chr2_+_72476159 1.141 ENSMUST00000102691.4
Cdca7
cell division cycle associated 7
chr9_+_106429399 0.991 ENSMUST00000150576.1
Rpl29
ribosomal protein L29
chr6_-_100671126 0.972 ENSMUST00000089245.6
ENSMUST00000113312.2
ENSMUST00000170667.1
Shq1


SHQ1 homolog (S. cerevisiae)


chr7_+_28808795 0.963 ENSMUST00000172529.1
Hnrnpl
heterogeneous nuclear ribonucleoprotein L
chr7_+_35802593 0.962 ENSMUST00000052454.2
E130304I02Rik
RIKEN cDNA E130304I02 gene
chr10_+_128083273 0.956 ENSMUST00000026459.5
Atp5b
ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit
chr5_+_45493374 0.950 ENSMUST00000046122.6
Lap3
leucine aminopeptidase 3
chr9_+_106429537 0.919 ENSMUST00000059802.6
Rpl29
ribosomal protein L29
chr7_+_78783119 0.896 ENSMUST00000032840.4
Mrps11
mitochondrial ribosomal protein S11
chr8_-_115706994 0.878 ENSMUST00000069009.6
Maf
avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog
chr13_-_35906324 0.858 ENSMUST00000174230.1
ENSMUST00000171686.2
Rpp40

ribonuclease P 40 subunit

chr17_+_28328471 0.854 ENSMUST00000042334.8
Rpl10a
ribosomal protein L10A
chr4_-_120570252 0.843 ENSMUST00000030381.7
Ctps
cytidine 5'-triphosphate synthase
chr7_-_16816731 0.781 ENSMUST00000061390.7
Fkrp
fukutin related protein
chr9_-_20898592 0.770 ENSMUST00000004206.8
Eif3g
eukaryotic translation initiation factor 3, subunit G
chr9_-_108094459 0.694 ENSMUST00000081309.7
Apeh
acylpeptide hydrolase
chr13_+_37826225 0.683 ENSMUST00000128570.1
Rreb1
ras responsive element binding protein 1
chr16_+_92301266 0.666 ENSMUST00000063641.4
ENSMUST00000118064.1
Smim11

small integral membrane protein 11

chr3_+_122245625 0.638 ENSMUST00000178826.1
Gclm
glutamate-cysteine ligase, modifier subunit
chr2_+_145785980 0.607 ENSMUST00000110005.1
ENSMUST00000094480.4
Rin2

Ras and Rab interactor 2

chr3_+_95658771 0.556 ENSMUST00000178686.1
Mcl1
myeloid cell leukemia sequence 1
chr17_+_35879770 0.549 ENSMUST00000025292.8
Dhx16
DEAH (Asp-Glu-Ala-His) box polypeptide 16
chr18_-_77713978 0.525 ENSMUST00000074653.4
8030462N17Rik
RIKEN cDNA 8030462N17 gene
chr10_-_62602261 0.513 ENSMUST00000045866.7
Ddx21
DEAD (Asp-Glu-Ala-Asp) box polypeptide 21
chr9_-_78481724 0.487 ENSMUST00000042235.8
Eef1a1
eukaryotic translation elongation factor 1 alpha 1
chr11_+_75679259 0.452 ENSMUST00000017920.7
ENSMUST00000108426.1
ENSMUST00000108425.1
ENSMUST00000093115.3
Crk



v-crk sarcoma virus CT10 oncogene homolog (avian)



chr13_-_115101909 0.420 ENSMUST00000061673.7
Itga1
integrin alpha 1
chr3_+_95658714 0.359 ENSMUST00000037947.8
Mcl1
myeloid cell leukemia sequence 1
chr11_-_23665862 0.341 ENSMUST00000020523.3
Pex13
peroxisomal biogenesis factor 13
chr11_-_70220794 0.317 ENSMUST00000159867.1
Slc16a13
solute carrier family 16 (monocarboxylic acid transporters), member 13
chr5_-_25223153 0.286 ENSMUST00000066954.1
E130116L18Rik
RIKEN cDNA E130116L18 gene
chr11_-_70220776 0.282 ENSMUST00000141290.1
Slc16a13
solute carrier family 16 (monocarboxylic acid transporters), member 13
chr14_-_72709534 0.281 ENSMUST00000162478.1
Fndc3a
fibronectin type III domain containing 3A
chr18_-_3337539 0.254 ENSMUST00000142690.1
ENSMUST00000025069.4
ENSMUST00000082141.5
ENSMUST00000165086.1
ENSMUST00000149803.1
Crem




cAMP responsive element modulator




chr7_+_3617357 0.239 ENSMUST00000076657.4
ENSMUST00000108644.1
Ndufa3

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3

chr6_-_99632376 0.227 ENSMUST00000176255.1
Gm20696
predicted gene 20696
chr11_-_70220969 0.206 ENSMUST00000060010.2
Slc16a13
solute carrier family 16 (monocarboxylic acid transporters), member 13
chr4_-_133672601 0.205 ENSMUST00000062118.4
ENSMUST00000067902.6
Pigv

phosphatidylinositol glycan anchor biosynthesis, class V

chr17_+_8165501 0.195 ENSMUST00000097419.3
ENSMUST00000024636.8
Fgfr1op

Fgfr1 oncogene partner

chrX_-_73458990 0.194 ENSMUST00000033737.8
ENSMUST00000077243.4
Haus7

HAUS augmin-like complex, subunit 7

chr11_-_84916338 0.191 ENSMUST00000103195.4
Znhit3
zinc finger, HIT type 3
chr1_+_58713241 0.183 ENSMUST00000114309.1
ENSMUST00000069333.7
Cflar

CASP8 and FADD-like apoptosis regulator

chr18_-_34651703 0.176 ENSMUST00000025228.5
ENSMUST00000133181.1
Cdc23

CDC23 cell division cycle 23

chr4_-_116627478 0.176 ENSMUST00000081182.4
ENSMUST00000030457.5
Nasp

nuclear autoantigenic sperm protein (histone-binding)

chr9_+_70012540 0.169 ENSMUST00000118198.1
ENSMUST00000119905.1
ENSMUST00000119413.1
ENSMUST00000140305.1
ENSMUST00000122087.1
Gtf2a2




general transcription factor II A, 2




chr2_-_50296680 0.162 ENSMUST00000144143.1
ENSMUST00000102769.4
ENSMUST00000133768.1
Mmadhc


methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria


chr7_-_35802968 0.128 ENSMUST00000061586.4
Zfp507
zinc finger protein 507
chr3_+_122245557 0.128 ENSMUST00000029769.7
Gclm
glutamate-cysteine ligase, modifier subunit
chr14_-_72709986 0.114 ENSMUST00000089017.5
Fndc3a
fibronectin type III domain containing 3A
chr2_+_155517948 0.111 ENSMUST00000029135.8
ENSMUST00000065973.2
ENSMUST00000103142.5
Acss2


acyl-CoA synthetase short-chain family member 2


chr11_-_70410010 0.078 ENSMUST00000019065.3
ENSMUST00000135148.1
Pelp1

proline, glutamic acid and leucine rich protein 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.7 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.8 3.4 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
0.5 9.3 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.5 4.6 GO:0030322 stabilization of membrane potential(GO:0030322)
0.3 1.0 GO:0090071 negative regulation of ribosome biogenesis(GO:0090071)
0.2 1.0 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.2 0.9 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.2 1.4 GO:0006271 DNA strand elongation involved in DNA replication(GO:0006271)
0.2 0.8 GO:0075525 viral translational termination-reinitiation(GO:0075525)
0.2 0.5 GO:1990859 cellular response to endothelin(GO:1990859)
0.1 1.0 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.1 5.3 GO:0006284 base-excision repair(GO:0006284)
0.1 0.2 GO:0014891 striated muscle atrophy(GO:0014891)
0.1 0.8 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.1 0.8 GO:0051409 response to nitrosative stress(GO:0051409)
0.1 1.7 GO:0031295 T cell costimulation(GO:0031295)
0.1 0.7 GO:1903689 regulation of wound healing, spreading of epidermal cells(GO:1903689) positive regulation of lamellipodium morphogenesis(GO:2000394)
0.1 0.9 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.1 1.8 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.1 0.3 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.1 0.8 GO:0046036 CTP biosynthetic process(GO:0006241) CTP metabolic process(GO:0046036)
0.0 2.7 GO:0021884 forebrain neuron development(GO:0021884)
0.0 0.9 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.1 GO:0006083 acetate metabolic process(GO:0006083)
0.0 1.7 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.0 1.9 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 0.9 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.0 0.2 GO:0009235 cobalamin metabolic process(GO:0009235)
0.0 0.9 GO:0070306 lens fiber cell differentiation(GO:0070306)
0.0 0.4 GO:0032516 positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.0 0.5 GO:0043330 response to exogenous dsRNA(GO:0043330)
0.0 0.5 GO:1903427 negative regulation of reactive oxygen species biosynthetic process(GO:1903427)
0.0 0.7 GO:0050435 beta-amyloid metabolic process(GO:0050435)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 5.3 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.5 2.7 GO:0001674 female germ cell nucleus(GO:0001674)
0.5 1.4 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.3 0.8 GO:0017109 glutamate-cysteine ligase complex(GO:0017109)
0.2 7.7 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 1.3 GO:0042587 glycogen granule(GO:0042587)
0.1 1.9 GO:0042788 polysomal ribosome(GO:0042788)
0.1 0.9 GO:0005655 nucleolar ribonuclease P complex(GO:0005655)
0.1 1.0 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.1 0.9 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.8 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.8 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 1.7 GO:0000786 nucleosome(GO:0000786)
0.0 1.0 GO:0045120 pronucleus(GO:0045120)
0.0 0.2 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 0.2 GO:0031501 mannosyltransferase complex(GO:0031501)
0.0 0.2 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 1.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 1.6 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.9 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.2 GO:0070652 HAUS complex(GO:0070652)
0.0 0.4 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 0.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.3 GO:0005779 integral component of peroxisomal membrane(GO:0005779)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 5.3 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.4 1.7 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.4 4.6 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.3 0.8 GO:0004357 glutamate-cysteine ligase activity(GO:0004357)
0.2 0.8 GO:0003883 CTP synthase activity(GO:0003883)
0.2 1.0 GO:0043532 angiostatin binding(GO:0043532)
0.1 0.4 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.1 0.9 GO:0051434 BH3 domain binding(GO:0051434)
0.1 0.7 GO:0008242 omega peptidase activity(GO:0008242)
0.1 1.0 GO:1990715 mRNA CDS binding(GO:1990715)
0.1 0.9 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.1 0.9 GO:0004526 ribonuclease P activity(GO:0004526)
0.1 1.6 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 0.5 GO:0097322 7SK snRNA binding(GO:0097322)
0.1 1.4 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.2 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 3.4 GO:0019955 cytokine binding(GO:0019955)
0.0 3.7 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 2.2 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.3 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 9.1 GO:0042393 histone binding(GO:0042393)
0.0 0.1 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 4.3 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.9 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 0.2 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0 0.5 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.8 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 0.2 GO:0031996 thioesterase binding(GO:0031996)
0.0 1.3 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 0.8 GO:0003743 translation initiation factor activity(GO:0003743)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.4 PID_BMP_PATHWAY BMP receptor signaling
0.1 7.6 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.7 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.5 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 1.1 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.4 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.0 0.2 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.9 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 1.6 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.6 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 5.3 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.2 7.7 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.1 1.4 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.1 3.4 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.1 2.3 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.1 1.0 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 0.8 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.8 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.5 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 0.8 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 3.3 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.0 0.1 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.0 0.2 REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis