Motif ID: Rhox11

Z-value: 0.349


Transcription factors associated with Rhox11:

Gene SymbolEntrez IDGene Name
Rhox11 ENSMUSG00000051038.9 Rhox11



Activity profile for motif Rhox11.

activity profile for motif Rhox11


Sorted Z-values histogram for motif Rhox11

Sorted Z-values for motif Rhox11



Network of associatons between targets according to the STRING database.



First level regulatory network of Rhox11

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_17574268 2.838 ENSMUST00000030568.7
Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr5_+_17574726 2.188 ENSMUST00000169603.1
Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr5_-_139130159 2.001 ENSMUST00000129851.1
Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr5_+_21186267 1.433 ENSMUST00000036031.8
Gsap
gamma-secretase activating protein
chr5_+_111733924 1.278 ENSMUST00000180627.1
Gm26897
predicted gene, 26897
chr11_+_29373618 1.093 ENSMUST00000040182.6
ENSMUST00000109477.1
Ccdc88a

coiled coil domain containing 88A

chr11_-_30198232 0.986 ENSMUST00000102838.3
Sptbn1
spectrin beta, non-erythrocytic 1
chr15_+_8169067 0.962 ENSMUST00000110617.1
2410089E03Rik
RIKEN cDNA 2410089E03 gene
chr16_+_29579347 0.884 ENSMUST00000038867.6
ENSMUST00000161186.1
Opa1

optic atrophy 1

chr3_+_156561792 0.856 ENSMUST00000074015.4
Negr1
neuronal growth regulator 1
chr17_+_79614900 0.775 ENSMUST00000040368.2
Rmdn2
regulator of microtubule dynamics 2
chr2_-_150362708 0.764 ENSMUST00000051153.5
3300002I08Rik
RIKEN cDNA 3300002I08 gene
chr16_+_29579331 0.734 ENSMUST00000160597.1
Opa1
optic atrophy 1
chr8_+_104831572 0.726 ENSMUST00000059449.6
Ces2b
carboxyesterase 2B
chr13_+_49653297 0.666 ENSMUST00000021824.7
Nol8
nucleolar protein 8
chr10_+_58394361 0.639 ENSMUST00000020077.4
Lims1
LIM and senescent cell antigen-like domains 1
chr12_+_74288735 0.614 ENSMUST00000095617.1
1700086L19Rik
RIKEN cDNA 1700086L19 gene
chr9_-_20521375 0.597 ENSMUST00000068296.7
ENSMUST00000174462.1
Zfp266

zinc finger protein 266

chr13_-_3611064 0.569 ENSMUST00000096069.3
BC016423
cDNA sequence BC016423
chr10_+_58394381 0.561 ENSMUST00000105468.1
Lims1
LIM and senescent cell antigen-like domains 1
chr8_+_72492915 0.529 ENSMUST00000181452.1
Gm17435
predicted gene, 17435
chr18_+_62977854 0.516 ENSMUST00000150267.1
Napg
N-ethylmaleimide sensitive fusion protein attachment protein gamma
chr4_+_126556994 0.509 ENSMUST00000147675.1
Clspn
claspin
chr18_-_24709348 0.508 ENSMUST00000067987.1
Gm9955
predicted gene 9955
chr16_+_23107413 0.491 ENSMUST00000023599.6
ENSMUST00000168891.1
Eif4a2

eukaryotic translation initiation factor 4A2

chr1_-_162866502 0.472 ENSMUST00000046049.7
Fmo1
flavin containing monooxygenase 1
chr14_+_51091077 0.466 ENSMUST00000022428.5
ENSMUST00000171688.1
Rnase4
Ang
ribonuclease, RNase A family 4
angiogenin, ribonuclease, RNase A family, 5
chr7_-_46795661 0.445 ENSMUST00000123725.1
Hps5
Hermansky-Pudlak syndrome 5 homolog (human)
chr15_+_25742314 0.394 ENSMUST00000135981.1
Myo10
myosin X
chr1_+_99772765 0.394 ENSMUST00000086738.3
Cntnap5b
contactin associated protein-like 5B
chr8_-_105827190 0.390 ENSMUST00000041400.5
Ranbp10
RAN binding protein 10
chr9_-_20644726 0.370 ENSMUST00000148631.1
ENSMUST00000131128.1
ENSMUST00000151861.1
ENSMUST00000131343.1
ENSMUST00000086458.3
Fbxl12




F-box and leucine-rich repeat protein 12




chr5_+_121220191 0.368 ENSMUST00000119892.2
ENSMUST00000042614.6
Gm15800

predicted gene 15800

chr9_-_60838200 0.361 ENSMUST00000063858.7
Gm9869
predicted gene 9869
chr16_+_23107754 0.358 ENSMUST00000077605.5
ENSMUST00000115341.3
Eif4a2

eukaryotic translation initiation factor 4A2

chr2_-_131352857 0.339 ENSMUST00000059372.4
Rnf24
ring finger protein 24
chr15_+_36179299 0.327 ENSMUST00000047348.3
Spag1
sperm associated antigen 1
chr7_-_28008416 0.322 ENSMUST00000180024.1
Zfp850
zinc finger protein 850
chr7_-_46795881 0.275 ENSMUST00000107653.1
ENSMUST00000107654.1
ENSMUST00000014562.7
ENSMUST00000152759.1
Hps5



Hermansky-Pudlak syndrome 5 homolog (human)



chr1_-_175688353 0.269 ENSMUST00000104984.1
Chml
choroideremia-like
chr13_+_47043499 0.269 ENSMUST00000037025.8
ENSMUST00000143868.1
Kdm1b

lysine (K)-specific demethylase 1B

chr9_-_44713196 0.253 ENSMUST00000144251.1
ENSMUST00000156918.1
Phldb1

pleckstrin homology-like domain, family B, member 1

chr11_+_70639118 0.251 ENSMUST00000055184.6
ENSMUST00000108551.2
Gp1ba

glycoprotein 1b, alpha polypeptide

chr5_+_143933059 0.250 ENSMUST00000166847.1
Rsph10b
radial spoke head 10 homolog B (Chlamydomonas)
chr2_+_178118975 0.233 ENSMUST00000108917.1
Phactr3
phosphatase and actin regulator 3
chr9_+_50768228 0.233 ENSMUST00000042391.6
Fdxacb1
ferredoxin-fold anticodon binding domain containing 1
chr19_-_8818924 0.221 ENSMUST00000153281.1
Ttc9c
tetratricopeptide repeat domain 9C
chr1_+_87853264 0.217 ENSMUST00000027517.7
Dgkd
diacylglycerol kinase, delta
chr15_+_7129557 0.209 ENSMUST00000067190.5
ENSMUST00000164529.1
Lifr

leukemia inhibitory factor receptor

chr6_-_106800051 0.201 ENSMUST00000013882.7
ENSMUST00000049675.4
ENSMUST00000113239.3
Crbn


cereblon


chr1_-_169969143 0.174 ENSMUST00000027989.6
ENSMUST00000111353.3
Hsd17b7

hydroxysteroid (17-beta) dehydrogenase 7

chr6_+_128662379 0.155 ENSMUST00000032518.4
Clec2h
C-type lectin domain family 2, member h
chr8_+_94386438 0.135 ENSMUST00000161576.1
Herpud1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr4_-_119383732 0.128 ENSMUST00000044781.2
ENSMUST00000084307.3
Ccdc30

coiled-coil domain containing 30

chr11_-_97700327 0.124 ENSMUST00000018681.7
Pcgf2
polycomb group ring finger 2
chr5_-_114858682 0.119 ENSMUST00000066959.4
Gm9936
predicted gene 9936
chr7_+_46796088 0.115 ENSMUST00000006774.4
ENSMUST00000165031.1
Gtf2h1

general transcription factor II H, polypeptide 1

chr14_-_46822232 0.114 ENSMUST00000111817.1
ENSMUST00000079314.5
Gmfb

glia maturation factor, beta

chr11_+_98741805 0.112 ENSMUST00000064187.5
Thra
thyroid hormone receptor alpha
chrX_-_111536325 0.102 ENSMUST00000156639.1
Rps6ka6
ribosomal protein S6 kinase polypeptide 6
chr3_+_90603767 0.100 ENSMUST00000001046.5
ENSMUST00000107330.1
S100a4

S100 calcium binding protein A4

chr9_-_16378231 0.092 ENSMUST00000082170.5
Fat3
FAT tumor suppressor homolog 3 (Drosophila)
chr6_-_34977999 0.073 ENSMUST00000044387.7
2010107G12Rik
RIKEN cDNA 2010107G12 gene
chr8_+_14888022 0.063 ENSMUST00000123990.1
ENSMUST00000027554.7
Cln8

ceroid-lipofuscinosis, neuronal 8

chr18_+_6765171 0.061 ENSMUST00000097680.5
Rab18
RAB18, member RAS oncogene family
chr13_+_40886758 0.045 ENSMUST00000069958.7
Gcnt2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr8_+_3353415 0.040 ENSMUST00000098966.3
A430078G23Rik
RIKEN cDNA A430078G23 gene
chr10_-_59951753 0.031 ENSMUST00000020308.3
Ddit4
DNA-damage-inducible transcript 4
chr3_+_68468162 0.023 ENSMUST00000182532.1
Schip1
schwannomin interacting protein 1
chr9_+_86743616 0.019 ENSMUST00000036426.6
Prss35
protease, serine, 35
chr8_+_94386486 0.013 ENSMUST00000034220.7
Herpud1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr17_-_57059795 0.012 ENSMUST00000040280.7
Slc25a23
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
chr14_-_20496780 0.009 ENSMUST00000022353.3
Mss51
MSS51 mitochondrial translational activator
chr17_+_25727726 0.006 ENSMUST00000047273.1
Rpusd1
RNA pseudouridylate synthase domain containing 1
chr5_+_98329298 0.003 ENSMUST00000080333.3
1700007G11Rik
RIKEN cDNA 1700007G11 gene
chr7_-_119720742 0.003 ENSMUST00000033236.7
Thumpd1
THUMP domain containing 1
chr19_+_57452900 0.002 ENSMUST00000026073.6
ENSMUST00000026072.3
Trub1

TruB pseudouridine (psi) synthase homolog 1 (E. coli)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 5.0 GO:0003350 pulmonary myocardium development(GO:0003350)
0.4 1.6 GO:0014042 positive regulation of neuron maturation(GO:0014042)
0.2 1.2 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.2 1.1 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.2 2.0 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.2 1.0 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.2 0.5 GO:0032430 positive regulation of phospholipase A2 activity(GO:0032430)
0.1 1.0 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.1 1.4 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.1 0.2 GO:0038165 oncostatin-M-mediated signaling pathway(GO:0038165)
0.1 0.7 GO:1902570 protein localization to nucleolus(GO:1902570)
0.1 0.2 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0 0.4 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.0 0.5 GO:0070995 toxin metabolic process(GO:0009404) NADPH oxidation(GO:0070995)
0.0 0.3 GO:0034720 histone H3-K4 demethylation(GO:0034720)
0.0 0.1 GO:0017055 negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055)
0.0 0.3 GO:0018344 protein geranylgeranylation(GO:0018344)
0.0 0.3 GO:0042730 fibrinolysis(GO:0042730)
0.0 0.1 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.0 0.3 GO:2001197 regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.0 0.2 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.0 0.2 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.0 0.1 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
0.0 0.1 GO:0001306 age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571) amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.0 0.8 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 0.2 GO:0006968 cellular defense response(GO:0006968)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.6 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.2 1.0 GO:0032437 cuticular plate(GO:0032437)
0.2 0.7 GO:0031084 BLOC-2 complex(GO:0031084)
0.2 0.5 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.2 2.0 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 0.2 GO:0009328 phenylalanine-tRNA ligase complex(GO:0009328)
0.1 0.3 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.1 GO:1990037 Lewy body core(GO:1990037)
0.0 0.3 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 1.0 GO:0035869 ciliary transition zone(GO:0035869)
0.0 0.3 GO:0045180 basal cortex(GO:0045180)
0.0 0.2 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0 0.1 GO:0000439 core TFIIH complex(GO:0000439)
0.0 0.1 GO:0001739 sex chromatin(GO:0001739)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 5.0 GO:0038191 neuropilin binding(GO:0038191)
0.2 1.6 GO:1901612 phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)
0.2 2.0 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.1 0.5 GO:0005483 soluble NSF attachment protein activity(GO:0005483)
0.1 0.5 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 0.2 GO:0004923 leukemia inhibitory factor receptor activity(GO:0004923) oncostatin-M receptor activity(GO:0004924)
0.1 0.4 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.1 0.3 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.1 0.4 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.1 0.2 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.0 0.2 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.0 1.1 GO:0043422 protein kinase B binding(GO:0043422)
0.0 1.0 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.1 GO:0002153 steroid receptor RNA activator RNA binding(GO:0002153)
0.0 1.4 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.2 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.2 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.1 GO:0050786 RAGE receptor binding(GO:0050786)
0.0 0.0 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.1 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.0 0.8 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.3 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.0 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.0 5.0 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.2 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 0.3 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 1.0 PID_TGFBR_PATHWAY TGF-beta receptor signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 1.2 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 1.0 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 0.8 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 0.3 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.5 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds