Motif ID: Foxo4

Z-value: 0.733


Transcription factors associated with Foxo4:

Gene SymbolEntrez IDGene Name
Foxo4 ENSMUSG00000042903.7 Foxo4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxo4mm10_v2_chrX_+_101254528_1012545740.333.7e-02Click!


Activity profile for motif Foxo4.

activity profile for motif Foxo4


Sorted Z-values histogram for motif Foxo4

Sorted Z-values for motif Foxo4



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxo4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_5796924 3.884 ENSMUST00000174808.1
Malat1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chr7_-_103813913 3.140 ENSMUST00000098192.3
Hbb-bt
hemoglobin, beta adult t chain
chr2_-_175338197 2.150 ENSMUST00000121393.2
Gm4631
predicted gene 4631
chr2_-_175931051 2.017 ENSMUST00000108949.2
ENSMUST00000109018.2
Gm8898

predicted gene 8898

chr2_-_175141999 1.754 ENSMUST00000109062.1
ENSMUST00000109059.1
ENSMUST00000109060.1
Gm14399


predicted gene 14399


chr2_+_176521056 1.697 ENSMUST00000108997.2
ENSMUST00000178443.1
Gm14431

predicted gene 14431

chr2_+_175372436 1.597 ENSMUST00000131676.1
ENSMUST00000109048.2
ENSMUST00000109047.2
Gm4723


predicted gene 4723


chr2_-_175703646 1.562 ENSMUST00000109027.2
ENSMUST00000179061.1
ENSMUST00000131041.1
Gm4245


predicted gene 4245


chr2_+_175469985 1.562 ENSMUST00000109042.3
ENSMUST00000109002.2
ENSMUST00000109043.2
ENSMUST00000143490.1
Gm8923



predicted gene 8923



chr2_-_177957239 1.517 ENSMUST00000108928.1
ENSMUST00000108932.1
ENSMUST00000108930.2
Gm14326


predicted gene 14326


chr7_-_4778141 1.400 ENSMUST00000094892.5
Il11
interleukin 11
chr5_-_70842617 1.388 ENSMUST00000031119.1
Gabrg1
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1
chr2_+_176670522 1.385 ENSMUST00000121956.1
ENSMUST00000108985.2
Gm14306

predicted gene 14306

chr2_+_176226569 1.343 ENSMUST00000099009.2
ENSMUST00000136719.1
2210418O10Rik

RIKEN cDNA 2210418O10 gene

chr11_+_101246960 1.308 ENSMUST00000107282.3
Ramp2
receptor (calcitonin) activity modifying protein 2
chr4_-_32950813 1.261 ENSMUST00000084750.1
ENSMUST00000084748.2
Ankrd6

ankyrin repeat domain 6

chr2_-_176927809 1.232 ENSMUST00000099007.2
Gm14296
predicted gene 14296
chr2_+_178023284 1.219 ENSMUST00000108925.3
ENSMUST00000108926.2
Etohi1

ethanol induced 1

chr6_+_42286676 1.139 ENSMUST00000031894.6
Clcn1
chloride channel 1
chr2_-_175206899 1.111 ENSMUST00000109055.1
ENSMUST00000099028.3
ENSMUST00000109056.1
ENSMUST00000109058.2
Gm14391



predicted gene 14391



chr8_+_79639618 1.084 ENSMUST00000173078.1
ENSMUST00000173286.1
Otud4

OTU domain containing 4

chr17_-_51831884 1.060 ENSMUST00000124222.1
Satb1
special AT-rich sequence binding protein 1
chr2_+_175965331 1.028 ENSMUST00000109007.1
ENSMUST00000174416.1
Gm2026

predicted gene 2026

chr8_+_26119361 0.997 ENSMUST00000014022.8
ENSMUST00000153528.1
ENSMUST00000131138.1
ENSMUST00000110575.1
Rnf170



ring finger protein 170



chr2_-_177840318 0.975 ENSMUST00000108939.2
ENSMUST00000150650.1
Gm14325

predicted gene 14325

chr11_-_77078404 0.961 ENSMUST00000102494.1
Ccdc55
coiled-coil domain containing 55
chr17_+_26202946 0.957 ENSMUST00000122058.1
ENSMUST00000025020.5
Rgs11

regulator of G-protein signaling 11

chr15_-_97767798 0.907 ENSMUST00000129223.2
ENSMUST00000126854.2
ENSMUST00000135080.1
Rapgef3


Rap guanine nucleotide exchange factor (GEF) 3


chr6_+_42286709 0.863 ENSMUST00000163936.1
Clcn1
chloride channel 1
chr17_-_23745829 0.817 ENSMUST00000046525.8
Kremen2
kringle containing transmembrane protein 2
chr18_-_38918642 0.811 ENSMUST00000040647.4
Fgf1
fibroblast growth factor 1
chr2_-_75938407 0.803 ENSMUST00000099996.3
Ttc30b
tetratricopeptide repeat domain 30B
chr2_+_177000956 0.796 ENSMUST00000108975.2
ENSMUST00000156844.1
Gm14419

predicted gene 14419

chr4_+_97777606 0.780 ENSMUST00000075448.6
ENSMUST00000092532.6
Nfia

nuclear factor I/A

chr17_+_78508063 0.764 ENSMUST00000024880.9
Vit
vitrin
chr2_+_176708328 0.740 ENSMUST00000108981.2
ENSMUST00000108980.2
Gm14305

predicted gene 14305

chr2_-_178078425 0.739 ENSMUST00000108924.2
ENSMUST00000131702.1
ENSMUST00000108923.1
Zfp931


zinc finger protein 931


chr2_+_176798612 0.736 ENSMUST00000118012.2
Gm14295
predicted gene 14295
chrX_+_85574018 0.732 ENSMUST00000048250.3
ENSMUST00000137438.1
ENSMUST00000146063.1
Tab3


TGF-beta activated kinase 1/MAP3K7 binding protein 3


chr2_-_176636318 0.698 ENSMUST00000108990.2
ENSMUST00000119149.1
ENSMUST00000117267.1
Gm14308


predicted gene 14308


chr2_-_175435782 0.686 ENSMUST00000152941.1
ENSMUST00000109045.2
Gm4724

predicted gene 4724

chr2_+_175869219 0.676 ENSMUST00000109011.1
Gm6710
predicted gene 6710
chr12_+_75308308 0.652 ENSMUST00000118602.1
ENSMUST00000118966.1
ENSMUST00000055390.5
Rhoj


ras homolog gene family, member J


chr2_-_176486773 0.649 ENSMUST00000120959.1
ENSMUST00000120521.1
Gm14434

predicted gene 14434

chr14_-_25903100 0.628 ENSMUST00000052286.8
Plac9a
placenta specific 9a
chr14_-_26182480 0.614 ENSMUST00000184142.1
Plac9b
placenta specific 9b
chr8_+_70234613 0.609 ENSMUST00000145078.1
Sugp2
SURP and G patch domain containing 2
chr4_-_6454262 0.602 ENSMUST00000029910.5
Nsmaf
neutral sphingomyelinase (N-SMase) activation associated factor
chr10_-_53638269 0.588 ENSMUST00000164393.1
Fam184a
family with sequence similarity 184, member A
chr8_+_26119611 0.572 ENSMUST00000140819.1
Rnf170
ring finger protein 170
chr11_-_42182924 0.547 ENSMUST00000020707.5
ENSMUST00000132971.1
Gabra1

gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1

chr7_-_4524229 0.536 ENSMUST00000154913.1
Tnni3
troponin I, cardiac 3
chr12_-_69892989 0.515 ENSMUST00000110567.1
ENSMUST00000171211.1
Map4k5

mitogen-activated protein kinase kinase kinase kinase 5

chr2_-_177206421 0.508 ENSMUST00000108964.1
Gm14410
predicted gene 14410
chr15_-_102625436 0.497 ENSMUST00000184485.1
ENSMUST00000185070.1
ENSMUST00000184616.1
ENSMUST00000108828.2
ATF7



Cyclic AMP-dependent transcription factor ATF-7



chrX_-_134600976 0.477 ENSMUST00000033621.6
Gla
galactosidase, alpha
chr6_+_95117740 0.449 ENSMUST00000032107.7
ENSMUST00000119582.1
Kbtbd8

kelch repeat and BTB (POZ) domain containing 8

chr8_-_105943382 0.445 ENSMUST00000038896.7
Lcat
lecithin cholesterol acyltransferase
chr11_-_85139939 0.403 ENSMUST00000108075.2
Usp32
ubiquitin specific peptidase 32
chr8_-_45410539 0.395 ENSMUST00000034056.4
ENSMUST00000167106.1
Tlr3

toll-like receptor 3

chr18_-_6490808 0.386 ENSMUST00000028100.6
ENSMUST00000050542.5
Epc1

enhancer of polycomb homolog 1 (Drosophila)

chr9_-_119322421 0.380 ENSMUST00000040853.4
Oxsr1
oxidative-stress responsive 1
chr2_-_45110336 0.355 ENSMUST00000028229.6
ENSMUST00000152232.1
Zeb2

zinc finger E-box binding homeobox 2

chr1_+_171437535 0.349 ENSMUST00000043839.4
F11r
F11 receptor
chr6_+_56714891 0.283 ENSMUST00000031805.8
Avl9
AVL9 homolog (S. cerevisiase)
chr6_-_128424883 0.270 ENSMUST00000001559.8
Itfg2
integrin alpha FG-GAP repeat containing 2
chr15_-_102625061 0.268 ENSMUST00000184077.1
ENSMUST00000184906.1
ENSMUST00000169033.1
ATF7


Cyclic AMP-dependent transcription factor ATF-7


chr2_-_144011202 0.251 ENSMUST00000016072.5
ENSMUST00000037875.5
Rrbp1

ribosome binding protein 1

chr8_-_47352348 0.247 ENSMUST00000110367.2
Stox2
storkhead box 2
chr15_-_80014808 0.202 ENSMUST00000000500.6
Pdgfb
platelet derived growth factor, B polypeptide
chr3_+_107895916 0.198 ENSMUST00000172247.1
ENSMUST00000167387.1
Gstm5

glutathione S-transferase, mu 5

chr5_-_90366176 0.193 ENSMUST00000014421.8
ENSMUST00000081914.6
ENSMUST00000168058.2
Ankrd17


ankyrin repeat domain 17


chr1_+_171213969 0.191 ENSMUST00000005820.4
ENSMUST00000075469.5
ENSMUST00000155126.1
Nr1i3


nuclear receptor subfamily 1, group I, member 3


chr7_-_3629874 0.172 ENSMUST00000155592.1
ENSMUST00000108641.3
Tfpt

TCF3 (E2A) fusion partner

chr10_-_40257648 0.171 ENSMUST00000019982.7
Gtf3c6
general transcription factor IIIC, polypeptide 6, alpha
chr14_+_32028989 0.159 ENSMUST00000022460.4
Galnt15
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15
chr14_-_32085595 0.128 ENSMUST00000022461.4
ENSMUST00000067955.5
ENSMUST00000124303.1
ENSMUST00000112000.1
Dph3



diphthamine biosynthesis 3



chr11_-_102579461 0.124 ENSMUST00000107081.1
Gm11627
predicted gene 11627
chr4_+_45972233 0.106 ENSMUST00000102929.1
Tdrd7
tudor domain containing 7
chr9_+_57076395 0.087 ENSMUST00000168177.1
Sin3a
transcriptional regulator, SIN3A (yeast)
chr5_-_24445254 0.084 ENSMUST00000030800.6
Fastk
Fas-activated serine/threonine kinase
chr9_+_57076343 0.078 ENSMUST00000168678.1
Sin3a
transcriptional regulator, SIN3A (yeast)
chrX_+_7579666 0.044 ENSMUST00000115740.1
ENSMUST00000115739.1
Foxp3

forkhead box P3

chr7_-_27355944 0.033 ENSMUST00000003857.6
Shkbp1
Sh3kbp1 binding protein 1
chr11_+_105589970 0.030 ENSMUST00000168598.1
ENSMUST00000100330.3
Tanc2

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2

chr5_-_24445166 0.024 ENSMUST00000115043.1
ENSMUST00000115041.1
Fastk

Fas-activated serine/threonine kinase

chr11_-_83649349 0.017 ENSMUST00000001008.5
Ccl3
chemokine (C-C motif) ligand 3
chr15_-_102624922 0.009 ENSMUST00000183765.1
ATF7
Cyclic AMP-dependent transcription factor ATF-7
chr16_-_64771146 0.008 ENSMUST00000076991.6
4930453N24Rik
RIKEN cDNA 4930453N24 gene
chr12_+_69893105 0.005 ENSMUST00000021466.8
Atl1
atlastin GTPase 1
chr11_-_102365111 0.004 ENSMUST00000006749.9
Slc4a1
solute carrier family 4 (anion exchanger), member 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.9 GO:0035063 nuclear speck organization(GO:0035063)
0.3 0.8 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.2 0.9 GO:1904451 regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904451) positive regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904453)
0.2 1.3 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.2 2.0 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 0.4 GO:0045349 regulation of dendritic cell cytokine production(GO:0002730) interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of interferon-beta biosynthetic process(GO:0045359)
0.1 0.4 GO:2000686 regulation of rubidium ion transmembrane transporter activity(GO:2000686)
0.1 0.3 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.1 0.5 GO:0001980 regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980)
0.1 0.4 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372)
0.1 1.3 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1 1.9 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1 0.2 GO:0003104 positive regulation of glomerular filtration(GO:0003104) negative regulation of phosphatidylinositol biosynthetic process(GO:0010512) phenotypic switching(GO:0036166) metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.1 0.2 GO:0039533 regulation of MDA-5 signaling pathway(GO:0039533)
0.1 1.1 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.1 0.5 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.1 0.4 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.1 0.2 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.1 0.7 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0 0.8 GO:0072189 ureter development(GO:0072189)
0.0 0.4 GO:0014029 neural crest formation(GO:0014029)
0.0 1.1 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.3 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.2 GO:0070458 detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458)
0.0 0.0 GO:0033092 positive regulation of immature T cell proliferation in thymus(GO:0033092)
0.0 0.4 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 1.4 GO:0046888 negative regulation of hormone secretion(GO:0046888)
0.0 0.8 GO:0042073 intraciliary transport(GO:0042073)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.3 1.3 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.2 0.9 GO:0097574 lateral part of cell(GO:0097574) basolateral part of cell(GO:1990794) rod bipolar cell terminal bouton(GO:1990795)
0.1 0.5 GO:1990584 cardiac Troponin complex(GO:1990584)
0.1 3.9 GO:0034707 chloride channel complex(GO:0034707)
0.1 0.4 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 1.0 GO:0044292 dendrite terminus(GO:0044292)
0.0 0.8 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.3 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.8 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.4 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.2 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.2 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.1 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.0 1.1 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 0.2 GO:0031011 Ino80 complex(GO:0031011)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.1 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.3 1.3 GO:0097643 amylin receptor activity(GO:0097643)
0.2 0.5 GO:0030172 troponin C binding(GO:0030172)
0.2 0.6 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.1 2.0 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 0.9 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1 1.9 GO:0004890 GABA-A receptor activity(GO:0004890)
0.1 0.5 GO:0016936 galactoside binding(GO:0016936)
0.1 0.4 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.1 0.8 GO:0044548 S100 protein binding(GO:0044548)
0.1 1.0 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.5 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.2 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.2 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.0 1.5 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 1.4 GO:0005125 cytokine activity(GO:0005125)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.8 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.3 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 1.1 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 0.4 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 1.1 PID_TNF_PATHWAY TNF receptor signaling pathway
0.0 0.8 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 2.1 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 0.5 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.1 1.1 REACTOME_TRAF6_MEDIATED_INDUCTION_OF_TAK1_COMPLEX Genes involved in TRAF6 mediated induction of TAK1 complex
0.0 0.4 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.5 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 0.9 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.0 0.5 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 1.1 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.3 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 1.3 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.5 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism