Motif ID: Nr0b1

Z-value: 0.610


Transcription factors associated with Nr0b1:

Gene SymbolEntrez IDGene Name
Nr0b1 ENSMUSG00000025056.4 Nr0b1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr0b1mm10_v2_chrX_+_86191764_86191782-0.038.7e-01Click!


Activity profile for motif Nr0b1.

activity profile for motif Nr0b1


Sorted Z-values histogram for motif Nr0b1

Sorted Z-values for motif Nr0b1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr0b1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_42697146 1.948 ENSMUST00000054883.2
Pou3f3
POU domain, class 3, transcription factor 3
chr2_-_54085542 1.672 ENSMUST00000100089.2
Rprm
reprimo, TP53 dependent G2 arrest mediator candidate
chr7_+_19094594 1.551 ENSMUST00000049454.5
Six5
sine oculis-related homeobox 5
chr16_-_45844303 1.391 ENSMUST00000036355.6
Phldb2
pleckstrin homology-like domain, family B, member 2
chr16_-_45844228 1.355 ENSMUST00000076333.5
Phldb2
pleckstrin homology-like domain, family B, member 2
chr5_+_30913398 1.082 ENSMUST00000031055.5
Emilin1
elastin microfibril interfacer 1
chr7_+_79500081 1.018 ENSMUST00000181511.2
ENSMUST00000182937.1
AI854517

expressed sequence AI854517

chr5_-_99037342 0.938 ENSMUST00000161490.1
Prkg2
protein kinase, cGMP-dependent, type II
chr5_-_99037035 0.914 ENSMUST00000031277.6
Prkg2
protein kinase, cGMP-dependent, type II
chr17_-_70851189 0.880 ENSMUST00000059775.8
Tgif1
TGFB-induced factor homeobox 1
chr7_+_79500018 0.868 ENSMUST00000182495.1
ENSMUST00000183043.1
AI854517

expressed sequence AI854517

chrX_-_48034842 0.831 ENSMUST00000039026.7
Apln
apelin
chr11_+_102604370 0.822 ENSMUST00000057893.5
Fzd2
frizzled homolog 2 (Drosophila)
chr5_-_115436508 0.793 ENSMUST00000078701.3
4930430O22Rik
RIKEN cDNA 4930430O22 gene
chr5_+_64803513 0.755 ENSMUST00000165536.1
Klf3
Kruppel-like factor 3 (basic)
chr7_+_82867327 0.751 ENSMUST00000082237.5
Mex3b
mex3 homolog B (C. elegans)
chr2_-_65238625 0.730 ENSMUST00000112429.2
ENSMUST00000102726.1
ENSMUST00000112430.1
Cobll1


Cobl-like 1


chr11_+_77930800 0.705 ENSMUST00000093995.3
ENSMUST00000000646.7
Sez6

seizure related gene 6

chr8_-_105707933 0.662 ENSMUST00000013299.9
Enkd1
enkurin domain containing 1
chr11_+_94328242 0.629 ENSMUST00000021227.5
Ankrd40
ankyrin repeat domain 40
chr11_+_94327984 0.587 ENSMUST00000107818.2
ENSMUST00000051221.6
Ankrd40

ankyrin repeat domain 40

chr19_-_46039442 0.575 ENSMUST00000137771.1
Ldb1
LIM domain binding 1
chr10_-_81350389 0.542 ENSMUST00000020454.4
ENSMUST00000105324.2
ENSMUST00000154609.2
ENSMUST00000105323.1
Hmg20b



high mobility group 20B



chr4_+_148130883 0.536 ENSMUST00000084129.2
Mad2l2
MAD2 mitotic arrest deficient-like 2
chr2_+_30066419 0.466 ENSMUST00000067996.6
Set
SET nuclear oncogene
chr14_+_11553523 0.446 ENSMUST00000022264.6
Ptprg
protein tyrosine phosphatase, receptor type, G
chr9_+_80165013 0.433 ENSMUST00000035889.8
ENSMUST00000113268.1
Myo6

myosin VI

chr7_-_65371210 0.432 ENSMUST00000102592.3
Tjp1
tight junction protein 1
chr2_+_4718145 0.428 ENSMUST00000056914.6
Bend7
BEN domain containing 7
chr9_+_80165079 0.427 ENSMUST00000184480.1
Myo6
myosin VI
chr2_+_157279065 0.417 ENSMUST00000029171.5
Rpn2
ribophorin II
chr13_-_94358818 0.410 ENSMUST00000059598.2
Gm9776
predicted gene 9776
chr8_-_95434869 0.394 ENSMUST00000034249.6
Gtl3
gene trap locus 3
chr11_-_74723829 0.392 ENSMUST00000102520.2
Pafah1b1
platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
chr2_+_71786923 0.371 ENSMUST00000112101.1
ENSMUST00000028522.3
Itga6

integrin alpha 6

chr11_+_23306884 0.359 ENSMUST00000180046.1
Usp34
ubiquitin specific peptidase 34
chr1_-_9700209 0.354 ENSMUST00000088658.4
Mybl1
myeloblastosis oncogene-like 1
chr4_-_132422484 0.344 ENSMUST00000102568.3
Phactr4
phosphatase and actin regulator 4
chr2_+_157279026 0.344 ENSMUST00000116380.2
Rpn2
ribophorin II
chr18_+_35829798 0.319 ENSMUST00000060722.6
Cxxc5
CXXC finger 5
chr18_+_80046854 0.315 ENSMUST00000070219.7
Pard6g
par-6 partitioning defective 6 homolog gamma (C. elegans)
chr14_+_75845296 0.304 ENSMUST00000142061.1
Tpt1
tumor protein, translationally-controlled 1
chr13_-_106936907 0.299 ENSMUST00000080856.7
Ipo11
importin 11
chr7_+_28180226 0.297 ENSMUST00000172467.1
Dyrk1b
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
chr8_-_85080679 0.282 ENSMUST00000093357.5
Wdr83
WD repeat domain containing 83
chr3_+_86224665 0.281 ENSMUST00000107635.1
Lrba
LPS-responsive beige-like anchor
chr16_+_44173239 0.276 ENSMUST00000119746.1
Gm608
predicted gene 608
chr4_-_123750236 0.271 ENSMUST00000102636.3
Akirin1
akirin 1
chr3_-_123690806 0.269 ENSMUST00000154668.1
Ndst3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr5_+_110230975 0.267 ENSMUST00000031474.7
ENSMUST00000086674.5
Ankle2

ankyrin repeat and LEM domain containing 2

chr11_+_105181793 0.267 ENSMUST00000092537.3
ENSMUST00000015107.6
ENSMUST00000145048.1
Tlk2


tousled-like kinase 2 (Arabidopsis)


chr10_+_38965515 0.242 ENSMUST00000019992.5
Lama4
laminin, alpha 4
chr15_-_38078842 0.239 ENSMUST00000110336.2
Ubr5
ubiquitin protein ligase E3 component n-recognin 5
chr4_-_132422394 0.235 ENSMUST00000152271.1
ENSMUST00000084170.5
Phactr4

phosphatase and actin regulator 4

chr9_-_109059711 0.234 ENSMUST00000061973.4
Trex1
three prime repair exonuclease 1
chr1_+_140246216 0.225 ENSMUST00000119786.1
ENSMUST00000120796.1
ENSMUST00000060201.8
ENSMUST00000120709.1
Kcnt2



potassium channel, subfamily T, member 2



chr17_+_34898463 0.221 ENSMUST00000114033.2
ENSMUST00000078061.6
Ehmt2

euchromatic histone lysine N-methyltransferase 2

chr7_+_28180272 0.215 ENSMUST00000173223.1
Dyrk1b
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b
chr13_-_29984219 0.210 ENSMUST00000146092.1
E2f3
E2F transcription factor 3
chr4_-_129696817 0.205 ENSMUST00000102588.3
Tmem39b
transmembrane protein 39b
chr19_+_45015198 0.199 ENSMUST00000179108.1
Lzts2
leucine zipper, putative tumor suppressor 2
chr13_-_64274879 0.186 ENSMUST00000109770.1
Cdc14b
CDC14 cell division cycle 14B
chr11_-_70687917 0.184 ENSMUST00000108545.2
ENSMUST00000120261.1
ENSMUST00000036299.7
ENSMUST00000119120.1
ENSMUST00000100933.3
Camta2




calmodulin binding transcription activator 2




chr1_+_162570687 0.175 ENSMUST00000050010.4
ENSMUST00000150040.1
Vamp4

vesicle-associated membrane protein 4

chr11_+_23306910 0.169 ENSMUST00000137823.1
Usp34
ubiquitin specific peptidase 34
chr17_+_29490812 0.169 ENSMUST00000024811.6
Pim1
proviral integration site 1
chr8_-_85080652 0.166 ENSMUST00000152785.1
Wdr83
WD repeat domain containing 83
chr10_+_116301374 0.163 ENSMUST00000092167.5
Ptprb
protein tyrosine phosphatase, receptor type, B
chr2_-_80581380 0.160 ENSMUST00000111760.2
Nckap1
NCK-associated protein 1
chr11_+_105181527 0.158 ENSMUST00000106941.2
Tlk2
tousled-like kinase 2 (Arabidopsis)
chr6_+_47454320 0.155 ENSMUST00000031697.8
Cul1
cullin 1
chr4_+_116221633 0.153 ENSMUST00000030464.7
Pik3r3
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
chr2_-_80581234 0.125 ENSMUST00000028386.5
Nckap1
NCK-associated protein 1
chr2_+_85037448 0.119 ENSMUST00000168266.1
ENSMUST00000130729.1
Ssrp1

structure specific recognition protein 1

chr18_-_10030017 0.118 ENSMUST00000116669.1
ENSMUST00000092096.6
Usp14

ubiquitin specific peptidase 14

chr17_-_80728026 0.104 ENSMUST00000112389.2
ENSMUST00000025089.7
Map4k3

mitogen-activated protein kinase kinase kinase kinase 3

chr11_+_107547925 0.099 ENSMUST00000100305.1
ENSMUST00000075012.1
ENSMUST00000106746.1
Helz


helicase with zinc finger domain


chr17_-_84790517 0.092 ENSMUST00000112308.2
Lrpprc
leucine-rich PPR-motif containing
chr17_-_23745829 0.084 ENSMUST00000046525.8
Kremen2
kringle containing transmembrane protein 2
chr13_-_55488038 0.077 ENSMUST00000109921.2
ENSMUST00000109923.2
ENSMUST00000021950.8
Dbn1


drebrin 1


chr5_+_31193227 0.077 ENSMUST00000031029.8
ENSMUST00000133711.1
ENSMUST00000132471.1
Snx17


sorting nexin 17


chr15_+_80711292 0.060 ENSMUST00000067689.7
Tnrc6b
trinucleotide repeat containing 6b
chr19_-_6077183 0.054 ENSMUST00000025711.5
ENSMUST00000160590.1
Vps51

vacuolar protein sorting 51 homolog (S. cerevisiae)

chr11_+_50237002 0.034 ENSMUST00000180443.1
Gm26542
predicted gene, 26542
chr5_-_137531952 0.028 ENSMUST00000140139.1
Gnb2
guanine nucleotide binding protein (G protein), beta 2
chr9_+_57521232 0.023 ENSMUST00000000090.6
Cox5a
cytochrome c oxidase subunit Va
chr4_-_135971894 0.022 ENSMUST00000105852.1
Lypla2
lysophospholipase 2
chr12_+_49385174 0.021 ENSMUST00000110746.1
3110039M20Rik
RIKEN cDNA 3110039M20 gene
chr9_-_44881274 0.019 ENSMUST00000002095.3
ENSMUST00000114689.1
ENSMUST00000128768.1
Kmt2a


lysine (K)-specific methyltransferase 2A


chr9_+_110333402 0.017 ENSMUST00000133114.1
ENSMUST00000125759.1
Scap

SREBF chaperone

chr7_+_19359740 0.010 ENSMUST00000140836.1
Ppp1r13l
protein phosphatase 1, regulatory (inhibitor) subunit 13 like
chr9_-_110117379 0.002 ENSMUST00000111991.2
ENSMUST00000149199.1
ENSMUST00000035056.7
ENSMUST00000148287.1
ENSMUST00000127744.1
Dhx30




DEAH (Asp-Glu-Ala-His) box polypeptide 30





Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.9 GO:0072236 DCT cell differentiation(GO:0072069) metanephric loop of Henle development(GO:0072236) metanephric DCT cell differentiation(GO:0072240)
0.4 2.7 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.3 0.8 GO:1904020 regulation of G-protein coupled receptor internalization(GO:1904020)
0.3 1.9 GO:2001225 cellular hypotonic response(GO:0071476) regulation of chloride transport(GO:2001225)
0.2 0.8 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223)
0.1 0.6 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.1 0.6 GO:0043973 histone H3-K4 acetylation(GO:0043973)
0.1 0.5 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.1 1.6 GO:0014842 regulation of skeletal muscle satellite cell proliferation(GO:0014842)
0.1 0.8 GO:0072697 protein localization to cell cortex(GO:0072697)
0.1 0.4 GO:0051661 maintenance of centrosome location(GO:0051661)
0.1 0.3 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.1 0.2 GO:1902915 negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.1 0.3 GO:2000383 regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384)
0.1 0.2 GO:0036166 phenotypic switching(GO:0036166)
0.1 0.3 GO:0008078 zygotic determination of anterior/posterior axis, embryo(GO:0007354) mesodermal cell migration(GO:0008078)
0.1 0.9 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.1 0.4 GO:0035878 nail development(GO:0035878)
0.1 0.9 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.7 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.3 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 0.1 GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
0.0 1.1 GO:0070207 protein homotrimerization(GO:0070207)
0.0 0.4 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.4 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 0.2 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.0 0.5 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.0 0.1 GO:0000957 mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
0.0 0.7 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.0 0.3 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.1 GO:0010643 cell communication by chemical coupling(GO:0010643) negative regulation of locomotion involved in locomotory behavior(GO:0090327)
0.0 0.2 GO:0070561 vitamin D receptor signaling pathway(GO:0070561) positive regulation of cell proliferation involved in heart morphogenesis(GO:2000138)
0.0 0.2 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.0 0.2 GO:0090003 regulation of Golgi to plasma membrane protein transport(GO:0042996) regulation of establishment of protein localization to plasma membrane(GO:0090003)
0.0 0.5 GO:0007520 myoblast fusion(GO:0007520)
0.0 1.7 GO:0007050 cell cycle arrest(GO:0007050)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.7 GO:0045180 basal cortex(GO:0045180)
0.1 0.5 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
0.1 0.5 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.1 0.4 GO:0000235 astral microtubule(GO:0000235)
0.1 1.5 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.1 0.4 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 0.8 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.2 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.9 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 0.3 GO:0045298 tubulin complex(GO:0045298)
0.0 0.3 GO:0031209 SCAR complex(GO:0031209)
0.0 0.1 GO:1902737 dendritic filopodium(GO:1902737)
0.0 0.7 GO:0097440 apical dendrite(GO:0097440)
0.0 0.7 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.2 GO:0005605 basal lamina(GO:0005605)
0.0 0.1 GO:1990745 EARP complex(GO:1990745)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.9 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.2 1.1 GO:0098634 protein binding involved in cell-matrix adhesion(GO:0098634)
0.1 0.6 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.1 0.3 GO:0042328 heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328)
0.1 0.6 GO:0030274 LIM domain binding(GO:0030274)
0.1 1.9 GO:0071837 HMG box domain binding(GO:0071837)
0.1 0.8 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1 0.2 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.1 0.3 GO:0038132 neuregulin binding(GO:0038132)
0.1 1.4 GO:0008432 JUN kinase binding(GO:0008432)
0.0 0.4 GO:0071253 connexin binding(GO:0071253)
0.0 0.4 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 0.8 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.8 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.8 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.2 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0 0.7 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.5 GO:0000400 four-way junction DNA binding(GO:0000400)
0.0 0.2 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.4 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 0.2 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.2 GO:0043024 ribosomal small subunit binding(GO:0043024)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.9 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.1 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.2 PID_IL5_PATHWAY IL5-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.1 0.4 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.9 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.0 0.9 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.2 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.2 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.8 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)