Motif ID: Hoxc9

Z-value: 0.760


Transcription factors associated with Hoxc9:

Gene SymbolEntrez IDGene Name
Hoxc9 ENSMUSG00000036139.6 Hoxc9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hoxc9mm10_v2_chr15_+_102977032_1029770320.105.5e-01Click!


Activity profile for motif Hoxc9.

activity profile for motif Hoxc9


Sorted Z-values histogram for motif Hoxc9

Sorted Z-values for motif Hoxc9



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxc9

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_+_80000292 3.669 ENSMUST00000088735.3
Olfm4
olfactomedin 4
chr13_+_94083490 3.616 ENSMUST00000156071.1
Lhfpl2
lipoma HMGIC fusion partner-like 2
chr1_+_58210397 3.520 ENSMUST00000040442.5
Aox4
aldehyde oxidase 4
chr4_+_144893127 3.393 ENSMUST00000142808.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr2_-_26516620 3.279 ENSMUST00000132820.1
Notch1
notch 1
chr9_+_35423582 3.259 ENSMUST00000154652.1
Cdon
cell adhesion molecule-related/down-regulated by oncogenes
chr2_+_4300462 3.040 ENSMUST00000175669.1
Frmd4a
FERM domain containing 4A
chr16_-_37384915 3.020 ENSMUST00000114787.1
ENSMUST00000114782.1
ENSMUST00000023526.2
ENSMUST00000114775.1
Stxbp5l



syntaxin binding protein 5-like



chr2_+_70474923 2.976 ENSMUST00000100043.2
Sp5
trans-acting transcription factor 5
chr1_-_45503282 2.628 ENSMUST00000086430.4
Col5a2
collagen, type V, alpha 2
chr4_+_107830958 2.466 ENSMUST00000106731.2
Lrp8
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
chr8_-_120228221 2.137 ENSMUST00000183235.1
A330074K22Rik
RIKEN cDNA A330074K22 gene
chr16_-_37384940 2.044 ENSMUST00000114781.1
ENSMUST00000114780.1
Stxbp5l

syntaxin binding protein 5-like

chr18_+_65582239 2.019 ENSMUST00000182684.1
Zfp532
zinc finger protein 532
chrX_-_141474034 1.885 ENSMUST00000101205.2
Col4a6
collagen, type IV, alpha 6
chr17_-_49564262 1.817 ENSMUST00000057610.6
Daam2
dishevelled associated activator of morphogenesis 2
chr4_+_100776664 1.801 ENSMUST00000030257.8
ENSMUST00000097955.2
Cachd1

cache domain containing 1

chr3_+_66985680 1.386 ENSMUST00000065047.6
Rsrc1
arginine/serine-rich coiled-coil 1
chrX_+_56609751 1.332 ENSMUST00000144068.1
Slc9a6
solute carrier family 9 (sodium/hydrogen exchanger), member 6
chr10_+_4710119 1.311 ENSMUST00000105588.1
ENSMUST00000105589.1
Esr1

estrogen receptor 1 (alpha)

chr2_+_91256144 1.306 ENSMUST00000154959.1
ENSMUST00000059566.4
Pacsin3

protein kinase C and casein kinase substrate in neurons 3

chr18_+_65582281 1.301 ENSMUST00000183319.1
Zfp532
zinc finger protein 532
chr6_-_99044414 1.277 ENSMUST00000177507.1
ENSMUST00000123992.1
Foxp1

forkhead box P1

chr2_-_84650714 1.231 ENSMUST00000111697.2
ENSMUST00000111670.2
ENSMUST00000111696.1
ENSMUST00000111678.1
ENSMUST00000111690.1
ENSMUST00000111695.1
ENSMUST00000111677.1
ENSMUST00000111698.1
ENSMUST00000099941.2
ENSMUST00000111676.1
ENSMUST00000111694.1
ENSMUST00000111675.1
ENSMUST00000111689.1
ENSMUST00000111687.1
ENSMUST00000111692.1
ENSMUST00000111685.1
ENSMUST00000111686.1
ENSMUST00000111688.1
ENSMUST00000111693.1
ENSMUST00000111684.1
Ctnnd1



















catenin (cadherin associated protein), delta 1



















chr11_+_3330401 1.214 ENSMUST00000045153.4
Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr2_-_84650676 1.088 ENSMUST00000067232.3
Ctnnd1
catenin (cadherin associated protein), delta 1
chrX_-_143933089 1.070 ENSMUST00000087313.3
Dcx
doublecortin
chr2_-_84650490 1.069 ENSMUST00000066177.3
Ctnnd1
catenin (cadherin associated protein), delta 1
chr2_-_84650760 1.064 ENSMUST00000111691.1
Ctnnd1
catenin (cadherin associated protein), delta 1
chr4_-_150003130 1.062 ENSMUST00000084117.6
H6pd
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
chr18_+_65582390 1.007 ENSMUST00000169679.1
ENSMUST00000183326.1
Zfp532

zinc finger protein 532

chr17_-_57000018 0.960 ENSMUST00000002740.2
Pspn
persephin
chrX_-_105928547 0.935 ENSMUST00000101305.2
Atrx
alpha thalassemia/mental retardation syndrome X-linked homolog (human)
chr2_+_128967383 0.915 ENSMUST00000110320.2
ENSMUST00000110319.2
Zc3h6

zinc finger CCCH type containing 6

chr6_-_119388671 0.895 ENSMUST00000169744.1
Adipor2
adiponectin receptor 2
chr4_-_91376433 0.890 ENSMUST00000107109.2
ENSMUST00000107111.2
ENSMUST00000107120.1
Elavl2


ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)


chr10_-_13324250 0.858 ENSMUST00000105543.1
Phactr2
phosphatase and actin regulator 2
chr7_-_116038734 0.809 ENSMUST00000166877.1
Sox6
SRY-box containing gene 6
chr10_-_13324160 0.789 ENSMUST00000105545.4
Phactr2
phosphatase and actin regulator 2
chr19_-_10880370 0.736 ENSMUST00000133303.1
Tmem109
transmembrane protein 109
chr11_-_80080928 0.593 ENSMUST00000103233.3
ENSMUST00000061283.8
Crlf3

cytokine receptor-like factor 3

chr2_-_177578199 0.591 ENSMUST00000108945.1
ENSMUST00000108943.1
Gm14406

predicted gene 14406

chr11_+_85353156 0.590 ENSMUST00000108061.1
ENSMUST00000108062.1
ENSMUST00000108056.1
ENSMUST00000138423.1
ENSMUST00000074875.4
ENSMUST00000092821.3
Bcas3





breast carcinoma amplified sequence 3





chr2_+_175010241 0.583 ENSMUST00000109069.1
ENSMUST00000109070.2
Gm14444

predicted gene 14444

chr17_+_24426676 0.527 ENSMUST00000024946.5
Eci1
enoyl-Coenzyme A delta isomerase 1
chr2_+_91255954 0.522 ENSMUST00000134699.1
Pacsin3
protein kinase C and casein kinase substrate in neurons 3
chr4_+_136143497 0.501 ENSMUST00000008016.2
Id3
inhibitor of DNA binding 3
chr10_-_88605017 0.441 ENSMUST00000119185.1
ENSMUST00000121629.1
Mybpc1

myosin binding protein C, slow-type

chr9_-_89705017 0.405 ENSMUST00000058488.6
Tmed3
transmembrane emp24 domain containing 3
chr2_-_91255995 0.405 ENSMUST00000180732.1
Gm17281
predicted gene, 17281
chr4_+_137594140 0.336 ENSMUST00000105840.1
ENSMUST00000055131.6
ENSMUST00000105839.1
ENSMUST00000105838.1
Usp48



ubiquitin specific peptidase 48



chr8_+_54954728 0.326 ENSMUST00000033915.7
Gpm6a
glycoprotein m6a
chr6_+_125145235 0.307 ENSMUST00000119527.1
ENSMUST00000088276.6
ENSMUST00000051171.7
ENSMUST00000117675.1
Iffo1



intermediate filament family orphan 1



chr3_+_66985700 0.282 ENSMUST00000046542.6
ENSMUST00000162693.1
Rsrc1

arginine/serine-rich coiled-coil 1

chr5_-_44101668 0.240 ENSMUST00000087441.4
ENSMUST00000074113.6
Prom1

prominin 1

chr4_-_91376490 0.205 ENSMUST00000107124.3
Elavl2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr5_+_67260696 0.196 ENSMUST00000161233.1
ENSMUST00000160352.1
Tmem33

transmembrane protein 33

chr3_+_66985647 0.189 ENSMUST00000162362.1
ENSMUST00000065074.7
Rsrc1

arginine/serine-rich coiled-coil 1

chr10_-_92162753 0.166 ENSMUST00000182197.1
Rmst
rhabdomyosarcoma 2 associated transcript (non-coding RNA)
chr9_-_7835255 0.150 ENSMUST00000074246.6
Birc2
baculoviral IAP repeat-containing 2
chr13_+_113209659 0.052 ENSMUST00000038144.8
Esm1
endothelial cell-specific molecule 1
chrX_-_37104523 0.043 ENSMUST00000130324.1
Upf3b
UPF3 regulator of nonsense transcripts homolog B (yeast)
chr13_+_58281183 0.001 ENSMUST00000180882.1
ENSMUST00000180452.1
Gm26555

predicted gene, 26555


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.5 GO:0046110 xanthine metabolic process(GO:0046110)
1.1 3.3 GO:0003219 atrioventricular node development(GO:0003162) cardiac right ventricle formation(GO:0003219)
0.9 4.5 GO:0060690 epithelial cell differentiation involved in salivary gland development(GO:0060690)
0.9 2.6 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.4 3.3 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.4 1.2 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.3 1.3 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.3 3.4 GO:0042572 retinol metabolic process(GO:0042572)
0.3 2.5 GO:0038026 reelin-mediated signaling pathway(GO:0038026)
0.2 0.9 GO:0097393 post-embryonic appendage morphogenesis(GO:0035120) post-embryonic limb morphogenesis(GO:0035127) post-embryonic forelimb morphogenesis(GO:0035128) telomeric repeat-containing RNA transcription(GO:0097393) telomeric repeat-containing RNA transcription from RNA pol II promoter(GO:0097394) regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901580) negative regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901581) positive regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901582)
0.1 1.2 GO:0031547 brain-derived neurotrophic factor receptor signaling pathway(GO:0031547)
0.1 1.3 GO:0061470 interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619)
0.1 3.0 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.1 0.9 GO:0061042 vascular wound healing(GO:0061042)
0.1 1.9 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.1 5.1 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.1 0.4 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.1 0.2 GO:0072139 glomerular parietal epithelial cell differentiation(GO:0072139)
0.1 1.8 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 3.0 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.1 3.7 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1 1.0 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 0.8 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.1 1.1 GO:0006098 pentose-phosphate shunt(GO:0006098)
0.0 0.1 GO:1902527 positive regulation of protein K48-linked ubiquitination(GO:1902524) positive regulation of protein monoubiquitination(GO:1902527)
0.0 1.9 GO:0046677 response to antibiotic(GO:0046677)
0.0 0.6 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0 0.7 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.0 0.5 GO:0030903 notochord development(GO:0030903)
0.0 0.6 GO:0071158 positive regulation of cell cycle arrest(GO:0071158)
0.0 1.0 GO:0001658 branching involved in ureteric bud morphogenesis(GO:0001658)
0.0 0.0 GO:1903896 positive regulation of IRE1-mediated unfolded protein response(GO:1903896)
0.0 0.1 GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 GO:0005588 collagen type V trimer(GO:0005588)
0.7 3.3 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.4 4.5 GO:0005915 zonula adherens(GO:0005915)
0.4 1.9 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.3 3.7 GO:0042581 specific granule(GO:0042581)
0.2 0.9 GO:1990421 subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707)
0.2 1.2 GO:0044308 axonal spine(GO:0044308)
0.2 1.3 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.1 0.2 GO:0071914 prominosome(GO:0071914)
0.1 0.4 GO:0005859 muscle myosin complex(GO:0005859)
0.0 0.6 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.4 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 2.7 GO:0005923 bicellular tight junction(GO:0005923)
0.0 2.1 GO:0005875 microtubule associated complex(GO:0005875)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.5 GO:0030151 molybdenum ion binding(GO:0030151)
0.6 2.5 GO:0038025 reelin receptor activity(GO:0038025)
0.5 3.4 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.4 1.3 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.4 1.2 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.4 1.1 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.2 0.9 GO:0097003 adipokinetic hormone receptor activity(GO:0097003)
0.2 0.6 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.1 1.2 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.1 1.8 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.1 0.9 GO:0015616 DNA translocase activity(GO:0015616)
0.1 0.5 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.1 3.3 GO:0005112 Notch binding(GO:0005112)
0.1 0.4 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 2.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.1 GO:0098770 FBXO family protein binding(GO:0098770)
0.0 5.1 GO:0019905 syntaxin binding(GO:0019905)
0.0 2.7 GO:0030674 protein binding, bridging(GO:0030674)
0.0 0.1 GO:0005171 hepatocyte growth factor receptor binding(GO:0005171)
0.0 1.8 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 5.2 GO:0045296 cadherin binding(GO:0045296)
0.0 0.5 GO:0005504 fatty acid binding(GO:0005504)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.3 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 4.5 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.1 4.2 NABA_COLLAGENS Genes encoding collagen proteins
0.1 3.5 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 3.3 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 3.4 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.3 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 2.0 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 2.3 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.5 REACTOME_PLATELET_SENSITIZATION_BY_LDL Genes involved in Platelet sensitization by LDL
0.1 3.3 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 4.2 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 1.3 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.3 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 0.5 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.4 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction