Motif ID: Plagl1

Z-value: 0.419


Transcription factors associated with Plagl1:

Gene SymbolEntrez IDGene Name
Plagl1 ENSMUSG00000019817.12 Plagl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Plagl1mm10_v2_chr10_+_13090788_13090843-0.647.6e-06Click!


Activity profile for motif Plagl1.

activity profile for motif Plagl1


Sorted Z-values histogram for motif Plagl1

Sorted Z-values for motif Plagl1



Network of associatons between targets according to the STRING database.



First level regulatory network of Plagl1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_152338619 1.686 ENSMUST00000030775.5
ENSMUST00000164662.1
Chd5

chromodomain helicase DNA binding protein 5

chr17_+_46297406 1.575 ENSMUST00000061722.6
ENSMUST00000166280.1
Dlk2

delta-like 2 homolog (Drosophila)

chr2_-_104257400 1.419 ENSMUST00000141159.1
D430041D05Rik
RIKEN cDNA D430041D05 gene
chr5_-_139130159 1.408 ENSMUST00000129851.1
Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr6_-_91807424 1.374 ENSMUST00000162300.1
Grip2
glutamate receptor interacting protein 2
chr6_-_91807318 1.105 ENSMUST00000159684.1
Grip2
glutamate receptor interacting protein 2
chr17_+_46297917 1.073 ENSMUST00000166617.1
ENSMUST00000170271.1
Dlk2

delta-like 2 homolog (Drosophila)

chr17_-_24644933 0.994 ENSMUST00000019684.5
Slc9a3r2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chr3_+_26331150 0.898 ENSMUST00000099182.2
A830092H15Rik
RIKEN cDNA A830092H15 gene
chr10_-_81482655 0.873 ENSMUST00000120508.1
ENSMUST00000118763.1
Celf5

CUGBP, Elav-like family member 5

chr19_+_6497772 0.849 ENSMUST00000113458.1
ENSMUST00000113459.1
Nrxn2

neurexin II

chr4_+_129136948 0.832 ENSMUST00000102600.3
Fndc5
fibronectin type III domain containing 5
chr15_-_43869993 0.804 ENSMUST00000067469.4
Tmem74
transmembrane protein 74
chr4_-_22488296 0.789 ENSMUST00000178174.1
Pou3f2
POU domain, class 3, transcription factor 2
chr11_-_120047144 0.775 ENSMUST00000103020.1
Aatk
apoptosis-associated tyrosine kinase
chr7_-_99695809 0.749 ENSMUST00000107086.2
Slco2b1
solute carrier organic anion transporter family, member 2b1
chr10_+_38965515 0.723 ENSMUST00000019992.5
Lama4
laminin, alpha 4
chr10_-_81014902 0.691 ENSMUST00000126317.1
ENSMUST00000092285.3
ENSMUST00000117805.1
Gng7


guanine nucleotide binding protein (G protein), gamma 7


chr18_+_32377176 0.674 ENSMUST00000091967.5
ENSMUST00000025239.7
Bin1

bridging integrator 1

chrX_+_163911401 0.673 ENSMUST00000140845.1
Ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr11_+_70018421 0.671 ENSMUST00000108588.1
Dlg4
discs, large homolog 4 (Drosophila)
chr5_-_34187670 0.669 ENSMUST00000042701.6
ENSMUST00000119171.1
Mxd4

Max dimerization protein 4

chr6_+_4504814 0.636 ENSMUST00000141483.1
Col1a2
collagen, type I, alpha 2
chr2_-_65567465 0.606 ENSMUST00000066432.5
Scn3a
sodium channel, voltage-gated, type III, alpha
chr2_-_39190687 0.595 ENSMUST00000142872.1
ENSMUST00000038874.5
Scai

suppressor of cancer cell invasion

chr11_+_98741805 0.592 ENSMUST00000064187.5
Thra
thyroid hormone receptor alpha
chr19_+_45047557 0.588 ENSMUST00000062213.5
ENSMUST00000111954.4
ENSMUST00000084493.6
Sfxn3


sideroflexin 3


chr4_+_101496648 0.540 ENSMUST00000106930.1
ENSMUST00000154120.1
Dnajc6

DnaJ (Hsp40) homolog, subfamily C, member 6

chr9_+_75625707 0.530 ENSMUST00000034702.4
Lysmd2
LysM, putative peptidoglycan-binding, domain containing 2
chr11_+_98741871 0.530 ENSMUST00000103139.4
Thra
thyroid hormone receptor alpha
chrX_-_73824938 0.518 ENSMUST00000114438.2
ENSMUST00000002080.5
Pdzd4

PDZ domain containing 4

chr2_-_65567505 0.509 ENSMUST00000100069.2
Scn3a
sodium channel, voltage-gated, type III, alpha
chr1_+_179546303 0.500 ENSMUST00000040706.8
Cnst
consortin, connexin sorting protein
chr3_-_108017877 0.469 ENSMUST00000004140.4
Gstm1
glutathione S-transferase, mu 1
chr7_-_139616309 0.463 ENSMUST00000166503.1
ENSMUST00000093991.3
E030019B06Rik

RIKEN cDNA E030019B06 gene

chr6_+_110645572 0.461 ENSMUST00000071076.6
ENSMUST00000172951.1
Grm7

glutamate receptor, metabotropic 7

chr17_+_25016343 0.434 ENSMUST00000024983.5
Ift140
intraflagellar transport 140
chr7_+_142533012 0.427 ENSMUST00000038675.6
Mrpl23
mitochondrial ribosomal protein L23
chr6_-_128143525 0.419 ENSMUST00000032503.5
ENSMUST00000112173.1
Tspan9

tetraspanin 9

chr5_+_125475814 0.403 ENSMUST00000031445.3
Aacs
acetoacetyl-CoA synthetase
chr3_-_108017806 0.374 ENSMUST00000126593.1
Gstm1
glutathione S-transferase, mu 1
chr10_-_95415484 0.371 ENSMUST00000172070.1
ENSMUST00000150432.1
Socs2

suppressor of cytokine signaling 2

chr6_-_128200598 0.369 ENSMUST00000071101.6
Gm10010
predicted gene 10010
chr2_-_18998126 0.363 ENSMUST00000006912.5
Pip4k2a
phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
chr4_+_148160613 0.361 ENSMUST00000047951.8
Fbxo2
F-box protein 2
chr12_-_69893162 0.339 ENSMUST00000049239.7
ENSMUST00000110570.1
Map4k5

mitogen-activated protein kinase kinase kinase kinase 5

chr5_-_136883115 0.339 ENSMUST00000057497.6
ENSMUST00000111103.1
Col26a1

collagen, type XXVI, alpha 1

chr19_+_4711153 0.337 ENSMUST00000008991.6
Sptbn2
spectrin beta, non-erythrocytic 2
chr6_+_83179568 0.337 ENSMUST00000113919.3
ENSMUST00000113918.1
ENSMUST00000141680.1
Dctn1


dynactin 1


chr11_+_95010277 0.321 ENSMUST00000124735.1
Samd14
sterile alpha motif domain containing 14
chr2_-_130642770 0.320 ENSMUST00000045761.6
Lzts3
leucine zipper, putative tumor suppressor family member 3
chr5_-_123012874 0.312 ENSMUST00000172729.1
Kdm2b
lysine (K)-specific demethylase 2B
chr12_+_100199435 0.306 ENSMUST00000110082.3
Calm1
calmodulin 1
chr2_+_174076296 0.303 ENSMUST00000155000.1
ENSMUST00000134876.1
ENSMUST00000147038.1
Stx16


syntaxin 16


chr7_+_5015466 0.286 ENSMUST00000086349.3
Zfp524
zinc finger protein 524
chr4_-_139092958 0.277 ENSMUST00000042844.6
Nbl1
neuroblastoma, suppression of tumorigenicity 1
chr5_-_92083455 0.274 ENSMUST00000169094.1
ENSMUST00000167918.1
G3bp2

GTPase activating protein (SH3 domain) binding protein 2

chr11_+_67966442 0.263 ENSMUST00000021286.4
ENSMUST00000108675.1
Stx8

syntaxin 8

chr11_+_53519725 0.261 ENSMUST00000108987.1
ENSMUST00000121334.1
ENSMUST00000117061.1
Sept8


septin 8


chr10_-_70599284 0.261 ENSMUST00000046513.3
Phyhipl
phytanoyl-CoA hydroxylase interacting protein-like
chr12_+_110889231 0.257 ENSMUST00000169597.1
ENSMUST00000165978.1
Tecpr2

tectonin beta-propeller repeat containing 2

chr5_-_143269958 0.245 ENSMUST00000161448.1
Zfp316
zinc finger protein 316
chr2_-_3419019 0.237 ENSMUST00000115084.1
ENSMUST00000115083.1
Meig1

meiosis expressed gene 1

chr4_-_45489794 0.233 ENSMUST00000146236.1
Shb
src homology 2 domain-containing transforming protein B
chr10_-_95415283 0.229 ENSMUST00000119917.1
Socs2
suppressor of cytokine signaling 2
chr4_+_47288057 0.226 ENSMUST00000140413.1
ENSMUST00000107731.2
Col15a1

collagen, type XV, alpha 1

chr1_-_179546261 0.220 ENSMUST00000027769.5
Tfb2m
transcription factor B2, mitochondrial
chr1_+_74588347 0.220 ENSMUST00000113732.1
Bcs1l
BCS1-like (yeast)
chr8_+_93810832 0.219 ENSMUST00000034198.8
ENSMUST00000125716.1
Gnao1

guanine nucleotide binding protein, alpha O

chr2_+_25428699 0.219 ENSMUST00000102919.3
Abca2
ATP-binding cassette, sub-family A (ABC1), member 2
chr9_+_108662098 0.217 ENSMUST00000035222.5
Slc25a20
solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20
chr1_+_74588289 0.215 ENSMUST00000113733.3
ENSMUST00000027358.4
Bcs1l

BCS1-like (yeast)

chr1_+_134455524 0.214 ENSMUST00000112232.1
ENSMUST00000027725.4
ENSMUST00000116528.1
Klhl12


kelch-like 12


chr5_-_92083667 0.213 ENSMUST00000113127.3
G3bp2
GTPase activating protein (SH3 domain) binding protein 2
chr2_-_152830615 0.208 ENSMUST00000146380.1
ENSMUST00000134902.1
ENSMUST00000134357.1
ENSMUST00000109820.3
Bcl2l1



BCL2-like 1



chr2_-_152831112 0.205 ENSMUST00000128172.1
Bcl2l1
BCL2-like 1
chr12_-_103443653 0.188 ENSMUST00000055071.8
Ifi27l2a
interferon, alpha-inducible protein 27 like 2A
chr2_-_132145057 0.179 ENSMUST00000028815.8
Slc23a2
solute carrier family 23 (nucleobase transporters), member 2
chr11_-_120727226 0.178 ENSMUST00000106148.3
ENSMUST00000026144.4
Dcxr

dicarbonyl L-xylulose reductase

chr13_+_5861489 0.177 ENSMUST00000000080.6
Klf6
Kruppel-like factor 6
chr8_-_25101985 0.176 ENSMUST00000128715.1
ENSMUST00000064883.6
Plekha2

pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2

chr2_-_152332639 0.175 ENSMUST00000028964.7
Rbck1
RanBP-type and C3HC4-type zinc finger containing 1
chr12_-_15816762 0.169 ENSMUST00000020922.7
Trib2
tribbles homolog 2 (Drosophila)
chr18_-_38601268 0.160 ENSMUST00000025295.6
Spry4
sprouty homolog 4 (Drosophila)
chr11_+_53519920 0.159 ENSMUST00000147912.1
Sept8
septin 8
chr1_-_88205674 0.151 ENSMUST00000119972.2
Dnajb3
DnaJ (Hsp40) homolog, subfamily B, member 3
chr11_+_32455362 0.135 ENSMUST00000051053.4
Ubtd2
ubiquitin domain containing 2
chr5_+_24393640 0.129 ENSMUST00000138168.1
ENSMUST00000115077.1
Abcb8

ATP-binding cassette, sub-family B (MDR/TAP), member 8

chr1_-_120074023 0.126 ENSMUST00000056089.7
Tmem37
transmembrane protein 37
chr5_-_136567242 0.123 ENSMUST00000175975.2
ENSMUST00000176216.2
ENSMUST00000176745.1
Cux1


cut-like homeobox 1


chrX_-_37085402 0.118 ENSMUST00000115231.3
Rpl39
ribosomal protein L39
chrX_+_99821021 0.105 ENSMUST00000096363.2
Tmem28
transmembrane protein 28
chr9_+_46273064 0.104 ENSMUST00000156440.1
ENSMUST00000034583.6
ENSMUST00000114552.3
Zfp259


zinc finger protein 259


chr6_-_48086530 0.093 ENSMUST00000073124.6
Zfp746
zinc finger protein 746
chr17_+_37193889 0.092 ENSMUST00000038844.6
Ubd
ubiquitin D
chr2_-_3419066 0.077 ENSMUST00000115082.3
Meig1
meiosis expressed gene 1
chr6_+_42286676 0.076 ENSMUST00000031894.6
Clcn1
chloride channel 1
chr1_-_52490736 0.075 ENSMUST00000170269.1
Nab1
Ngfi-A binding protein 1
chr6_+_42286709 0.073 ENSMUST00000163936.1
Clcn1
chloride channel 1
chr4_+_155249960 0.060 ENSMUST00000178473.1
ENSMUST00000105627.1
ENSMUST00000097747.2
2610002J02Rik


RIKEN cDNA 2610002J02 gene


chr17_+_29549783 0.058 ENSMUST00000048677.7
Tbc1d22b
TBC1 domain family, member 22B
chr15_-_52478228 0.054 ENSMUST00000081993.1
Gm10020
predicted pseudogene 10020
chr15_-_99251929 0.052 ENSMUST00000041190.9
ENSMUST00000163506.1
Mcrs1

microspherule protein 1

chr17_-_25868727 0.052 ENSMUST00000026828.5
Fam195a
family with sequence similarity 195, member A
chr11_+_53519871 0.049 ENSMUST00000120878.2
Sept8
septin 8
chr8_-_13974715 0.046 ENSMUST00000119182.1
ENSMUST00000062613.4
Tdrp

testis development related protein

chr3_-_89960562 0.036 ENSMUST00000069805.7
Atp8b2
ATPase, class I, type 8B, member 2
chr17_+_29660710 0.035 ENSMUST00000130423.1
Cmtr1
cap methyltransferase 1
chr17_-_35115428 0.034 ENSMUST00000172854.1
ENSMUST00000062657.4
Ly6g5b

lymphocyte antigen 6 complex, locus G5B

chr6_+_40325471 0.031 ENSMUST00000031977.8
Agk
acylglycerol kinase
chr16_+_32277449 0.030 ENSMUST00000155649.1
ENSMUST00000014218.8
ENSMUST00000171474.1
Rnf168


ring finger protein 168


chr13_+_74350299 0.026 ENSMUST00000022063.7
Ccdc127
coiled-coil domain containing 127
chr4_+_47288287 0.022 ENSMUST00000146967.1
Col15a1
collagen, type XV, alpha 1
chr17_-_25274299 0.021 ENSMUST00000172587.1
ENSMUST00000049911.9
ENSMUST00000173713.1
Ube2i


ubiquitin-conjugating enzyme E2I


chr3_+_124321031 0.020 ENSMUST00000058994.4
Tram1l1
translocation associated membrane protein 1-like 1
chr19_-_42779936 0.011 ENSMUST00000069298.6
ENSMUST00000160455.1
ENSMUST00000162004.1
Hps1


Hermansky-Pudlak syndrome 1 homolog (human)


chr9_-_59486610 0.010 ENSMUST00000171975.1
Arih1
ariadne ubiquitin-conjugating enzyme E2 binding protein homolog 1 (Drosophila)
chr5_-_124352233 0.001 ENSMUST00000111472.1
Cdk2ap1
CDK2 (cyclin-dependent kinase 2)-associated protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0017055 negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055)
0.2 2.5 GO:0014824 artery smooth muscle contraction(GO:0014824)
0.2 1.7 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.2 1.1 GO:0046684 response to pyrethroid(GO:0046684)
0.2 0.5 GO:0090004 positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.1 1.4 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.1 0.8 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.1 0.4 GO:0046898 response to cycloheximide(GO:0046898)
0.1 0.5 GO:0001661 conditioned taste aversion(GO:0001661)
0.1 0.5 GO:0072318 clathrin coat disassembly(GO:0072318)
0.1 0.8 GO:0032482 Rab protein signal transduction(GO:0032482)
0.1 0.3 GO:0035582 sequestering of BMP in extracellular matrix(GO:0035582)
0.1 0.7 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1 0.7 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.1 0.3 GO:0090063 positive regulation of microtubule nucleation(GO:0090063)
0.1 2.6 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.1 0.3 GO:0021993 initiation of neural tube closure(GO:0021993)
0.1 0.8 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.1 0.2 GO:0015882 L-ascorbic acid transport(GO:0015882) transepithelial L-ascorbic acid transport(GO:0070904)
0.1 0.2 GO:0042732 D-xylose metabolic process(GO:0042732)
0.1 0.7 GO:0048711 positive regulation of astrocyte differentiation(GO:0048711)
0.1 0.7 GO:0099628 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
0.0 0.8 GO:0042178 xenobiotic catabolic process(GO:0042178)
0.0 0.6 GO:0043589 skin morphogenesis(GO:0043589)
0.0 0.4 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.0 0.2 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.0 1.0 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.0 0.8 GO:0042297 vocal learning(GO:0042297) imitative learning(GO:0098596)
0.0 0.4 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0 0.4 GO:2000786 positive regulation of autophagosome assembly(GO:2000786)
0.0 0.2 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.0 0.2 GO:0032380 regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.0 0.2 GO:0015879 carnitine transport(GO:0015879)
0.0 0.2 GO:0048208 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.0 0.6 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.0 0.6 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.0 0.7 GO:0050873 brown fat cell differentiation(GO:0050873)
0.0 0.2 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.0 0.4 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.0 0.5 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.2 GO:0032693 negative regulation of interleukin-10 production(GO:0032693)
0.0 0.1 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.9 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.3 GO:0090161 Golgi ribbon formation(GO:0090161)
0.0 0.3 GO:0021692 cerebellar Purkinje cell layer morphogenesis(GO:0021692)
0.0 0.1 GO:0098703 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.0 0.7 GO:0060612 adipose tissue development(GO:0060612)
0.0 0.0 GO:0097309 cap1 mRNA methylation(GO:0097309)
0.0 0.1 GO:1904751 positive regulation of protein localization to nucleolus(GO:1904751)
0.0 0.0 GO:0070535 histone H2A K63-linked ubiquitination(GO:0070535)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0005584 collagen type I trimer(GO:0005584)
0.1 1.4 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 1.1 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 1.7 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 1.3 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 0.3 GO:0008091 spectrin(GO:0008091)
0.0 0.4 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 0.4 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.2 GO:0071797 LUBAC complex(GO:0071797)
0.0 0.5 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 0.4 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.7 GO:0005605 basal lamina(GO:0005605)
0.0 0.3 GO:0005869 dynactin complex(GO:0005869)
0.0 2.5 GO:0043198 dendritic shaft(GO:0043198)
0.0 0.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.2 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.8 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.9 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.5 GO:0032420 stereocilium(GO:0032420)
0.0 0.6 GO:0031201 SNARE complex(GO:0031201)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
0.4 1.1 GO:0002153 steroid receptor RNA activator RNA binding(GO:0002153)
0.2 0.5 GO:0070905 serine binding(GO:0070905)
0.1 1.4 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.1 0.4 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.1 0.6 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.1 0.7 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.1 0.4 GO:0047760 butyrate-CoA ligase activity(GO:0047760)
0.1 0.3 GO:0016015 morphogen activity(GO:0016015)
0.1 0.7 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.1 0.8 GO:0016151 nickel cation binding(GO:0016151)
0.1 0.3 GO:0031800 type 3 metabotropic glutamate receptor binding(GO:0031800)
0.1 0.2 GO:0070890 L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890)
0.1 1.1 GO:0031402 sodium ion binding(GO:0031402)
0.1 0.5 GO:0071253 connexin binding(GO:0071253)
0.1 0.2 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.1 0.2 GO:0015226 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.0 0.4 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.6 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.2 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.0 0.1 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.3 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 2.5 GO:0035254 glutamate receptor binding(GO:0035254)
0.0 1.0 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.0 0.3 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.8 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.8 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.4 GO:0048156 tau protein binding(GO:0048156)
0.0 0.3 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.8 GO:0005179 hormone activity(GO:0005179)
0.0 0.3 GO:0070840 dynein complex binding(GO:0070840)
0.0 0.2 GO:0055103 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.0 GO:0001729 ceramide kinase activity(GO:0001729)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.4 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.0 1.4 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.0 1.1 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.7 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 0.4 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.2 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.0 0.6 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.0 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 0.6 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 0.7 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 0.3 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 0.2 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 0.6 PID_IL2_1PATHWAY IL2-mediated signaling events
0.0 0.2 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.5 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 0.7 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.1 1.4 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.6 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.7 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.6 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.5 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.8 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 0.4 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.9 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.0 0.5 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.3 REACTOME_CA_DEPENDENT_EVENTS Genes involved in Ca-dependent events
0.0 0.6 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.0 1.1 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.4 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane