Motif ID: Pknox2_Pknox1

Z-value: 0.806

Transcription factors associated with Pknox2_Pknox1:

Gene SymbolEntrez IDGene Name
Pknox1 ENSMUSG00000006705.6 Pknox1
Pknox2 ENSMUSG00000035934.9 Pknox2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pknox2mm10_v2_chr9_-_37147257_371473230.444.3e-03Click!
Pknox1mm10_v2_chr17_+_31564749_31564854-0.067.0e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Pknox2_Pknox1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_113758638 5.062 ENSMUST00000099575.3
Grem1
gremlin 1
chr5_-_134747241 4.047 ENSMUST00000015138.9
Eln
elastin
chr2_-_34913976 3.568 ENSMUST00000028232.3
Phf19
PHD finger protein 19
chr11_+_78324200 3.531 ENSMUST00000102478.3
Aldoc
aldolase C, fructose-bisphosphate
chr9_+_44134562 3.504 ENSMUST00000034650.8
ENSMUST00000098852.2
Mcam

melanoma cell adhesion molecule

chr5_-_109558957 2.559 ENSMUST00000044579.7
Crlf2
cytokine receptor-like factor 2
chr18_+_56432116 2.329 ENSMUST00000070166.5
Gramd3
GRAM domain containing 3
chr2_+_105682463 2.326 ENSMUST00000140173.1
ENSMUST00000135412.1
ENSMUST00000138365.1
ENSMUST00000145744.1
Pax6



paired box gene 6



chr7_-_131410325 2.143 ENSMUST00000154602.1
Ikzf5
IKAROS family zinc finger 5
chr2_-_31141802 2.091 ENSMUST00000073879.5
ENSMUST00000100208.2
ENSMUST00000100207.2
ENSMUST00000113555.1
ENSMUST00000075326.4
ENSMUST00000113552.2
ENSMUST00000136181.1
Fnbp1






formin binding protein 1






chr15_+_32920723 2.015 ENSMUST00000022871.5
Sdc2
syndecan 2
chr16_-_43979050 1.892 ENSMUST00000165648.1
ENSMUST00000036321.7
Zdhhc23

zinc finger, DHHC domain containing 23

chr7_-_131410495 1.868 ENSMUST00000121033.1
ENSMUST00000046306.8
Ikzf5

IKAROS family zinc finger 5

chr15_-_100599864 1.776 ENSMUST00000177247.2
ENSMUST00000177505.2
Pou6f1

POU domain, class 6, transcription factor 1

chr9_+_113930934 1.764 ENSMUST00000084885.5
ENSMUST00000009885.7
Ubp1

upstream binding protein 1

chr11_+_78826575 1.716 ENSMUST00000147875.2
ENSMUST00000141321.1
Lyrm9

LYR motif containing 9

chr18_+_49832622 1.612 ENSMUST00000180611.1
Dmxl1
Dmx-like 1
chr2_-_116065047 1.521 ENSMUST00000028639.6
ENSMUST00000102538.4
Meis2

Meis homeobox 2

chr2_-_31142002 1.461 ENSMUST00000113560.1
ENSMUST00000113564.2
ENSMUST00000113562.2
Fnbp1


formin binding protein 1


chr7_+_112225856 1.453 ENSMUST00000050149.5
ENSMUST00000106647.1
ENSMUST00000106648.1
Mical2


microtubule associated monooxygenase, calponin and LIM domain containing 2


chr3_-_84270782 1.329 ENSMUST00000054990.4
Trim2
tripartite motif-containing 2
chr5_-_138619653 1.304 ENSMUST00000129832.1
Zfp68
zinc finger protein 68
chr11_-_72795801 1.302 ENSMUST00000079681.5
Cyb5d2
cytochrome b5 domain containing 2
chr1_-_52727457 1.260 ENSMUST00000156876.1
ENSMUST00000087701.3
Mfsd6

major facilitator superfamily domain containing 6

chr9_+_68653761 1.252 ENSMUST00000034766.7
Rora
RAR-related orphan receptor alpha
chr11_-_72796028 1.231 ENSMUST00000156294.1
Cyb5d2
cytochrome b5 domain containing 2
chr4_-_3938354 1.204 ENSMUST00000003369.3
Plag1
pleiomorphic adenoma gene 1
chr18_-_79109391 1.171 ENSMUST00000025430.8
ENSMUST00000161465.2
Setbp1

SET binding protein 1

chr7_-_48881032 1.156 ENSMUST00000058745.8
E2f8
E2F transcription factor 8
chr13_+_63815240 1.053 ENSMUST00000021926.5
ENSMUST00000095724.3
ENSMUST00000143449.1
ENSMUST00000067821.5
Ercc6l2



excision repair cross-complementing rodent repair deficiency, complementation group 6 like 2



chr14_+_54640952 1.022 ENSMUST00000169818.2
Gm17606
predicted gene, 17606
chr5_-_111761697 0.988 ENSMUST00000129146.1
ENSMUST00000137398.1
ENSMUST00000129065.1
E130006D01Rik


RIKEN cDNA E130006D01 gene


chr16_-_11176056 0.955 ENSMUST00000142389.1
ENSMUST00000138185.1
Zc3h7a

zinc finger CCCH type containing 7 A

chr8_-_115707778 0.943 ENSMUST00000109104.1
Maf
avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog
chr9_+_123366921 0.922 ENSMUST00000038863.7
Lars2
leucyl-tRNA synthetase, mitochondrial
chr5_+_150673739 0.911 ENSMUST00000016569.4
ENSMUST00000038900.8
Pds5b

PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)

chr3_-_67375163 0.908 ENSMUST00000166353.1
Gm17402
predicted gene, 17402
chr16_+_91391721 0.902 ENSMUST00000160764.1
Gm21970
predicted gene 21970
chr11_+_72796164 0.885 ENSMUST00000172220.1
Zzef1
zinc finger, ZZ-type with EF hand domain 1
chr17_-_66077022 0.884 ENSMUST00000150766.1
ENSMUST00000038116.5
Ankrd12

ankyrin repeat domain 12

chr3_-_51560816 0.873 ENSMUST00000037141.7
Setd7
SET domain containing (lysine methyltransferase) 7
chr13_-_58274121 0.847 ENSMUST00000091579.4
Gkap1
G kinase anchoring protein 1
chrX_-_48034842 0.844 ENSMUST00000039026.7
Apln
apelin
chr9_-_44134481 0.823 ENSMUST00000180670.1
Gm10687
predicted gene 10687
chr8_-_111522073 0.810 ENSMUST00000034437.6
ENSMUST00000038193.7
Wdr59

WD repeat domain 59

chrX_-_109013389 0.785 ENSMUST00000033597.8
Hmgn5
high-mobility group nucleosome binding domain 5
chr10_-_42276688 0.781 ENSMUST00000175881.1
ENSMUST00000056974.3
Foxo3

forkhead box O3

chr11_-_114795888 0.765 ENSMUST00000000206.3
Btbd17
BTB (POZ) domain containing 17
chr5_-_25498702 0.757 ENSMUST00000173073.1
ENSMUST00000045291.7
Kmt2c

lysine (K)-specific methyltransferase 2C

chr1_+_75549581 0.754 ENSMUST00000154101.1
Slc4a3
solute carrier family 4 (anion exchanger), member 3
chr2_-_30415509 0.744 ENSMUST00000134120.1
ENSMUST00000102854.3
Crat

carnitine acetyltransferase

chr8_+_20136455 0.739 ENSMUST00000179299.1
ENSMUST00000096485.4
Gm21811

predicted gene, 21811

chr8_+_56294552 0.732 ENSMUST00000034026.8
Hpgd
hydroxyprostaglandin dehydrogenase 15 (NAD)
chr2_-_30415767 0.719 ENSMUST00000102855.1
ENSMUST00000028207.6
Crat

carnitine acetyltransferase

chr10_-_42276744 0.702 ENSMUST00000105502.1
ENSMUST00000105501.1
Foxo3

forkhead box O3

chr9_-_82975475 0.673 ENSMUST00000034787.5
Phip
pleckstrin homology domain interacting protein
chr3_-_89402650 0.653 ENSMUST00000168325.1
ENSMUST00000057431.5
Lenep

lens epithelial protein

chr5_+_34761734 0.638 ENSMUST00000080036.2
Htt
huntingtin
chr11_+_23256001 0.634 ENSMUST00000020538.6
ENSMUST00000109551.1
ENSMUST00000102870.1
ENSMUST00000102869.1
Xpo1



exportin 1, CRM1 homolog (yeast)



chr2_-_132578128 0.618 ENSMUST00000028822.7
Gpcpd1
glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)
chr3_+_107631322 0.582 ENSMUST00000106703.1
Gm10961
predicted gene 10961
chr16_+_55973881 0.580 ENSMUST00000050248.8
Rpl24
ribosomal protein L24
chr7_-_48881596 0.569 ENSMUST00000119223.1
E2f8
E2F transcription factor 8
chr19_-_44069690 0.554 ENSMUST00000169092.1
Erlin1
ER lipid raft associated 1
chrX_-_102505359 0.545 ENSMUST00000087916.4
Hdac8
histone deacetylase 8
chr11_+_72796254 0.542 ENSMUST00000069395.5
Zzef1
zinc finger, ZZ-type with EF hand domain 1
chr2_-_132578155 0.504 ENSMUST00000110136.1
ENSMUST00000124107.1
ENSMUST00000060955.5
Gpcpd1


glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)


chr2_-_91649785 0.485 ENSMUST00000111333.1
Zfp408
zinc finger protein 408
chr10_-_123196916 0.475 ENSMUST00000020334.7
Usp15
ubiquitin specific peptidase 15
chr2_-_91649751 0.467 ENSMUST00000099714.3
Zfp408
zinc finger protein 408
chr2_-_160872985 0.461 ENSMUST00000109460.1
ENSMUST00000127201.1
Zhx3

zinc fingers and homeoboxes 3

chr2_-_132578244 0.442 ENSMUST00000110142.1
Gpcpd1
glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)
chr2_+_128967383 0.442 ENSMUST00000110320.2
ENSMUST00000110319.2
Zc3h6

zinc finger CCCH type containing 6

chr9_-_62980874 0.429 ENSMUST00000098651.4
Pias1
protein inhibitor of activated STAT 1
chr1_-_179546261 0.401 ENSMUST00000027769.5
Tfb2m
transcription factor B2, mitochondrial
chr1_+_194619815 0.387 ENSMUST00000027952.5
Plxna2
plexin A2
chrX_+_13632769 0.368 ENSMUST00000096492.3
Gpr34
G protein-coupled receptor 34
chr14_+_118137101 0.364 ENSMUST00000022728.2
Gpr180
G protein-coupled receptor 180
chr5_-_100500592 0.358 ENSMUST00000149714.1
ENSMUST00000046154.5
Lin54

lin-54 homolog (C. elegans)

chr2_+_146855861 0.336 ENSMUST00000099278.2
ENSMUST00000156232.1
Plk1s1

polo-like kinase 1 substrate 1

chr8_-_69184177 0.323 ENSMUST00000185176.1
Lzts1
leucine zipper, putative tumor suppressor 1
chr8_+_19682268 0.318 ENSMUST00000153710.1
ENSMUST00000127799.1
Gm6483

predicted gene 6483

chr19_+_32757497 0.303 ENSMUST00000013807.7
Pten
phosphatase and tensin homolog
chr3_+_51415986 0.295 ENSMUST00000029303.7
Naa15
N(alpha)-acetyltransferase 15, NatA auxiliary subunit
chr5_-_138619702 0.287 ENSMUST00000063262.4
Zfp68
zinc finger protein 68
chr10_+_7792891 0.284 ENSMUST00000015901.4
Ppil4
peptidylprolyl isomerase (cyclophilin)-like 4
chr4_+_141444654 0.283 ENSMUST00000006377.6
Zbtb17
zinc finger and BTB domain containing 17
chr9_+_67840386 0.270 ENSMUST00000077879.5
Vps13c
vacuolar protein sorting 13C (yeast)
chr11_-_80080928 0.266 ENSMUST00000103233.3
ENSMUST00000061283.8
Crlf3

cytokine receptor-like factor 3

chr5_-_138619751 0.254 ENSMUST00000085852.4
ENSMUST00000110905.2
Zfp68

zinc finger protein 68

chr19_+_11965817 0.250 ENSMUST00000025590.9
Osbp
oxysterol binding protein
chr4_+_3938904 0.244 ENSMUST00000120732.1
ENSMUST00000041122.4
ENSMUST00000121651.1
ENSMUST00000121210.1
ENSMUST00000119307.1
ENSMUST00000123769.1
Chchd7





coiled-coil-helix-coiled-coil-helix domain containing 7





chr10_-_62651194 0.240 ENSMUST00000020270.4
Ddx50
DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
chr7_+_25221417 0.234 ENSMUST00000055604.4
Zfp526
zinc finger protein 526
chr1_-_58973421 0.232 ENSMUST00000173590.1
ENSMUST00000027186.5
Trak2

trafficking protein, kinesin binding 2

chr4_+_11758147 0.219 ENSMUST00000029871.5
ENSMUST00000108303.1
Cdh17

cadherin 17

chr19_-_44069526 0.208 ENSMUST00000170801.1
Erlin1
ER lipid raft associated 1
chr1_+_156558844 0.201 ENSMUST00000166172.2
ENSMUST00000027888.6
Abl2

v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene)

chr2_-_160872829 0.198 ENSMUST00000176141.1
Zhx3
zinc fingers and homeoboxes 3
chr19_-_44069736 0.186 ENSMUST00000172041.1
ENSMUST00000071698.6
ENSMUST00000112028.3
Erlin1


ER lipid raft associated 1


chr5_+_44100442 0.178 ENSMUST00000072800.4
Gm16401
predicted gene 16401
chr5_-_34187670 0.174 ENSMUST00000042701.6
ENSMUST00000119171.1
Mxd4

Max dimerization protein 4

chr11_-_49712674 0.158 ENSMUST00000020624.6
ENSMUST00000145353.1
Cnot6

CCR4-NOT transcription complex, subunit 6

chr5_+_34989473 0.157 ENSMUST00000114284.1
ENSMUST00000114285.1
Rgs12

regulator of G-protein signaling 12

chr8_+_3655762 0.152 ENSMUST00000012849.8
ENSMUST00000169234.2
Retn

resistin

chr10_-_7792795 0.152 ENSMUST00000065124.1
6530403G13Rik
RIKEN cDNA 6530403G13 gene
chr6_+_95117740 0.152 ENSMUST00000032107.7
ENSMUST00000119582.1
Kbtbd8

kelch repeat and BTB (POZ) domain containing 8

chr3_+_116594959 0.138 ENSMUST00000029571.8
Sass6
spindle assembly 6 homolog (C. elegans)
chr2_+_30416031 0.114 ENSMUST00000042055.3
Ppp2r4
protein phosphatase 2A, regulatory subunit B (PR 53)
chr1_+_156558759 0.078 ENSMUST00000173929.1
Abl2
v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene)
chr13_+_109685994 0.065 ENSMUST00000074103.5
Pde4d
phosphodiesterase 4D, cAMP specific
chr2_+_30416096 0.060 ENSMUST00000113601.3
ENSMUST00000113603.3
Ppp2r4

protein phosphatase 2A, regulatory subunit B (PR 53)

chr7_+_98703091 0.055 ENSMUST00000033009.9
Prkrir
protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
chr7_-_126584220 0.054 ENSMUST00000128970.1
ENSMUST00000116269.2
Cln3

ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease)

chr8_+_25601591 0.053 ENSMUST00000155861.1
Whsc1l1
Wolf-Hirschhorn syndrome candidate 1-like 1 (human)
chr15_-_76723814 0.053 ENSMUST00000036247.8
C030006K11Rik
RIKEN cDNA C030006K11 gene
chr4_+_3938888 0.051 ENSMUST00000121110.1
ENSMUST00000108386.1
ENSMUST00000149544.1
Chchd7


coiled-coil-helix-coiled-coil-helix domain containing 7


chr1_-_74588117 0.042 ENSMUST00000066986.6
Zfp142
zinc finger protein 142
chr10_+_41810528 0.041 ENSMUST00000099931.3
Sesn1
sestrin 1
chr7_+_13398115 0.036 ENSMUST00000005791.7
Cabp5
calcium binding protein 5
chr5_+_93268247 0.029 ENSMUST00000121127.1
Ccng2
cyclin G2
chr7_-_45434590 0.029 ENSMUST00000107771.3
ENSMUST00000141761.1
Ruvbl2

RuvB-like protein 2

chr16_+_23107413 0.028 ENSMUST00000023599.6
ENSMUST00000168891.1
Eif4a2

eukaryotic translation initiation factor 4A2

chr9_-_71771535 0.026 ENSMUST00000122065.1
ENSMUST00000121322.1
ENSMUST00000072899.2
Cgnl1


cingulin-like 1


chr1_+_134182404 0.020 ENSMUST00000153856.1
ENSMUST00000082060.3
ENSMUST00000133701.1
ENSMUST00000132873.1
Chi3l1



chitinase 3-like 1



chr3_+_85574109 0.010 ENSMUST00000127348.1
ENSMUST00000107672.1
ENSMUST00000107674.1
Pet112


PET112 homolog (S. cerevisiae)



Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.1 GO:1901228 regulation of osteoclast proliferation(GO:0090289) positive regulation of transcription from RNA polymerase II promoter involved in heart development(GO:1901228) negative regulation of bone development(GO:1903011)
0.6 1.7 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
0.5 3.6 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.5 2.3 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
0.4 2.6 GO:0035745 T-helper 2 cell cytokine production(GO:0035745)
0.4 1.5 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.4 3.5 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.3 0.3 GO:1901630 negative regulation of presynaptic membrane organization(GO:1901630)
0.3 0.8 GO:1904020 regulation of G-protein coupled receptor internalization(GO:1904020)
0.3 1.6 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.2 0.6 GO:1904580 quinolinate biosynthetic process(GO:0019805) regulation of intracellular mRNA localization(GO:1904580)
0.2 1.5 GO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death(GO:1901300)
0.2 1.5 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.2 0.5 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.2 1.6 GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.1 0.6 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.1 0.9 GO:0045541 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.1 0.9 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.1 1.3 GO:2000188 regulation of cholesterol homeostasis(GO:2000188)
0.1 0.5 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.1 0.7 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.1 0.7 GO:0007567 parturition(GO:0007567) ductus arteriosus closure(GO:0097070)
0.1 1.2 GO:0060736 prostate gland growth(GO:0060736)
0.1 0.6 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.1 0.4 GO:0035590 purinergic nucleotide receptor signaling pathway(GO:0035590)
0.1 0.2 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.1 0.4 GO:0019236 response to pheromone(GO:0019236)
0.1 1.9 GO:0018345 protein palmitoylation(GO:0018345)
0.1 1.1 GO:0036297 interstrand cross-link repair(GO:0036297)
0.1 3.5 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.1 0.4 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.0 0.4 GO:0060174 limb bud formation(GO:0060174)
0.0 0.3 GO:0061734 parkin-mediated mitophagy in response to mitochondrial depolarization(GO:0061734)
0.0 0.8 GO:0061029 eyelid development in camera-type eye(GO:0061029)
0.0 0.3 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 0.3 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.0 0.4 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0 0.2 GO:2000325 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966) regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.0 0.2 GO:0038032 termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.0 4.0 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.0 0.9 GO:0070306 lens fiber cell differentiation(GO:0070306)
0.0 0.2 GO:0098937 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937)
0.0 0.3 GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407)
0.0 0.2 GO:2000252 negative regulation of feeding behavior(GO:2000252)
0.0 1.5 GO:0008542 visual learning(GO:0008542)
0.0 0.5 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 4.0 GO:0051291 protein heterooligomerization(GO:0051291)
0.0 0.8 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.0 2.3 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)
0.0 0.2 GO:0044144 regulation of growth of symbiont in host(GO:0044126) modulation of growth of symbiont involved in interaction with host(GO:0044144)
0.0 0.3 GO:0007398 ectoderm development(GO:0007398)
0.0 0.9 GO:0032543 mitochondrial translation(GO:0032543)
0.0 0.2 GO:0014029 neural crest formation(GO:0014029)
0.0 0.1 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
0.0 0.8 GO:0006749 glutathione metabolic process(GO:0006749)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 4.0 GO:0071953 elastic fiber(GO:0071953)
0.1 3.6 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 0.9 GO:0061700 GATOR2 complex(GO:0061700)
0.1 0.8 GO:0044666 MLL3/4 complex(GO:0044666)
0.1 0.6 GO:0005642 annulate lamellae(GO:0005642)
0.1 0.6 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.0 0.3 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.0 0.3 GO:0031415 NatA complex(GO:0031415)
0.0 2.3 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 6.1 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 2.1 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 0.1 GO:0098536 deuterosome(GO:0098536)
0.0 0.3 GO:0032993 protein-DNA complex(GO:0032993)
0.0 0.3 GO:0001891 phagocytic cup(GO:0001891)
0.0 5.4 GO:0009986 cell surface(GO:0009986)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.5 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.6 5.1 GO:0036122 BMP binding(GO:0036122)
0.4 1.6 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.4 1.5 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092)
0.3 1.3 GO:0008142 oxysterol binding(GO:0008142)
0.2 0.9 GO:0004920 interleukin-10 receptor activity(GO:0004920)
0.1 0.7 GO:0004954 icosanoid receptor activity(GO:0004953) prostanoid receptor activity(GO:0004954) prostaglandin receptor activity(GO:0004955)
0.1 2.3 GO:0003680 AT DNA binding(GO:0003680)
0.1 4.0 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 0.3 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.1 0.4 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.1 0.6 GO:0034452 dynactin binding(GO:0034452)
0.1 0.5 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.1 0.2 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.1 1.5 GO:0071949 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) FAD binding(GO:0071949)
0.1 0.9 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.1 1.9 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 0.6 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.1 0.4 GO:0061665 SUMO ligase activity(GO:0061665)
0.1 0.4 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 3.6 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.8 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 2.5 GO:0020037 heme binding(GO:0020037)
0.0 0.8 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.8 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.9 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 0.7 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.5 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 1.8 GO:0001221 transcription cofactor binding(GO:0001221)
0.0 0.2 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.4 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 2.6 GO:0005125 cytokine activity(GO:0005125)
0.0 5.7 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.3 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 1.3 GO:0017022 myosin binding(GO:0017022)
0.0 0.9 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.2 GO:0050811 GABA receptor binding(GO:0050811)
0.0 1.9 GO:0030165 PDZ domain binding(GO:0030165)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.1 PID_BMP_PATHWAY BMP receptor signaling
0.1 2.0 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.1 1.1 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 1.5 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.9 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 1.3 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.0 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 1.2 PID_CDC42_PATHWAY CDC42 signaling events
0.0 0.3 PID_MYC_PATHWAY C-MYC pathway
0.0 1.6 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.3 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1 2.0 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.1 3.5 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 1.5 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.0 1.5 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 1.3 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.9 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.6 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.4 REACTOME_REGULATION_OF_IFNG_SIGNALING Genes involved in Regulation of IFNG signaling
0.0 0.4 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.3 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.4 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.0 0.3 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation