Motif ID: Fli1

Z-value: 1.617


Transcription factors associated with Fli1:

Gene SymbolEntrez IDGene Name
Fli1 ENSMUSG00000016087.7 Fli1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Fli1mm10_v2_chr9_-_32541589_32541602-0.086.1e-01Click!


Activity profile for motif Fli1.

activity profile for motif Fli1


Sorted Z-values histogram for motif Fli1

Sorted Z-values for motif Fli1



Network of associatons between targets according to the STRING database.



First level regulatory network of Fli1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_175491130 43.723 ENSMUST00000027812.5
Rgs7
regulator of G protein signaling 7
chr10_+_26229707 40.236 ENSMUST00000060716.5
ENSMUST00000164660.1
Samd3

sterile alpha motif domain containing 3

chrX_-_136868537 21.370 ENSMUST00000058814.6
Rab9b
RAB9B, member RAS oncogene family
chr7_-_140082489 12.590 ENSMUST00000026541.7
Caly
calcyon neuron-specific vesicular protein
chr9_+_74848437 9.336 ENSMUST00000161862.1
ENSMUST00000162089.1
ENSMUST00000160017.1
ENSMUST00000160950.1
Gm16551


Gm20649
predicted gene 16551


predicted gene 20649
chr11_+_32000496 8.548 ENSMUST00000093219.3
Nsg2
neuron specific gene family member 2
chr4_+_43406435 8.190 ENSMUST00000098106.2
ENSMUST00000139198.1
Rusc2

RUN and SH3 domain containing 2

chr11_-_100759740 8.090 ENSMUST00000107361.2
Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr11_+_32000452 8.029 ENSMUST00000020537.2
ENSMUST00000109409.1
Nsg2

neuron specific gene family member 2

chr11_-_100759942 7.621 ENSMUST00000107363.2
Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr6_-_77979515 7.315 ENSMUST00000159626.1
ENSMUST00000075340.5
ENSMUST00000162273.1
Ctnna2


catenin (cadherin associated protein), alpha 2


chr11_-_68927049 6.954 ENSMUST00000038932.7
Odf4
outer dense fiber of sperm tails 4
chr6_-_77979652 6.706 ENSMUST00000161846.1
ENSMUST00000160894.1
Ctnna2

catenin (cadherin associated protein), alpha 2

chrX_+_123581700 5.868 ENSMUST00000178457.1
Gm6604
predicted gene 6604
chrX_+_123793665 5.709 ENSMUST00000178148.1
Gm5167
predicted gene 5167
chr5_+_117133567 5.528 ENSMUST00000179276.1
ENSMUST00000092889.5
ENSMUST00000145640.1
Taok3


TAO kinase 3


chr16_-_42340595 5.303 ENSMUST00000102817.4
Gap43
growth associated protein 43
chr8_+_23035116 5.274 ENSMUST00000117296.1
ENSMUST00000141784.2
Ank1

ankyrin 1, erythroid

chr9_+_118478182 5.148 ENSMUST00000111763.1
Eomes
eomesodermin homolog (Xenopus laevis)
chr2_+_65845833 4.909 ENSMUST00000053910.3
Csrnp3
cysteine-serine-rich nuclear protein 3
chr17_-_53539411 4.870 ENSMUST00000056198.3
Pp2d1
protein phosphatase 2C-like domain containing 1
chr2_+_65845767 4.847 ENSMUST00000122912.1
Csrnp3
cysteine-serine-rich nuclear protein 3
chr5_-_36398090 4.569 ENSMUST00000037370.7
ENSMUST00000070720.6
Sorcs2

sortilin-related VPS10 domain containing receptor 2

chr1_-_191318090 4.397 ENSMUST00000046770.9
Nenf
neuron derived neurotrophic factor
chr10_+_69533761 4.097 ENSMUST00000182884.1
Ank3
ankyrin 3, epithelial
chr5_-_106458440 3.994 ENSMUST00000086795.6
Barhl2
BarH-like 2 (Drosophila)
chr10_+_69533803 3.946 ENSMUST00000182155.1
ENSMUST00000183169.1
ENSMUST00000183148.1
Ank3


ankyrin 3, epithelial


chr15_-_76521902 3.855 ENSMUST00000164703.1
ENSMUST00000096365.3
Scrt1

scratch homolog 1, zinc finger protein (Drosophila)

chr8_+_23035099 3.762 ENSMUST00000117662.1
Ank1
ankyrin 1, erythroid
chrX_-_72656135 3.551 ENSMUST00000055966.6
Gabra3
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3
chr6_-_120822680 3.466 ENSMUST00000019354.8
Atp6v1e1
ATPase, H+ transporting, lysosomal V1 subunit E1
chr10_+_69534208 3.418 ENSMUST00000182439.1
ENSMUST00000092434.5
ENSMUST00000092432.5
ENSMUST00000092431.5
ENSMUST00000054167.8
ENSMUST00000047061.6
Ank3





ankyrin 3, epithelial





chr3_+_156561792 3.392 ENSMUST00000074015.4
Negr1
neuronal growth regulator 1
chr18_-_75697639 3.382 ENSMUST00000165559.1
Ctif
CBP80/20-dependent translation initiation factor
chr1_+_182763961 3.202 ENSMUST00000153348.1
Susd4
sushi domain containing 4
chr3_+_156562141 3.139 ENSMUST00000175773.1
Negr1
neuronal growth regulator 1
chr3_+_156561950 3.120 ENSMUST00000041425.5
ENSMUST00000106065.1
Negr1

neuronal growth regulator 1

chr7_+_3390629 3.007 ENSMUST00000182222.1
Cacng8
calcium channel, voltage-dependent, gamma subunit 8
chr15_-_76126538 2.900 ENSMUST00000054022.5
ENSMUST00000089654.3
BC024139

cDNA sequence BC024139

chr7_+_24862193 2.866 ENSMUST00000052897.4
ENSMUST00000170837.2
Gm9844
Gm9844
predicted pseudogene 9844
predicted pseudogene 9844
chr1_+_42952872 2.660 ENSMUST00000179766.1
Gpr45
G protein-coupled receptor 45
chr9_+_111439063 2.658 ENSMUST00000111879.3
Dclk3
doublecortin-like kinase 3
chr13_+_109260481 2.636 ENSMUST00000153234.1
Pde4d
phosphodiesterase 4D, cAMP specific
chr4_+_42655251 2.597 ENSMUST00000177785.1
Ccl27b
chemokine (C-C motif) ligand 27b
chr11_+_57011945 2.491 ENSMUST00000094179.4
Gria1
glutamate receptor, ionotropic, AMPA1 (alpha 1)
chr10_+_69534039 2.451 ENSMUST00000182557.1
Ank3
ankyrin 3, epithelial
chr11_+_57011798 2.405 ENSMUST00000036315.9
Gria1
glutamate receptor, ionotropic, AMPA1 (alpha 1)
chr13_+_42709482 2.397 ENSMUST00000066928.5
ENSMUST00000148891.1
Phactr1

phosphatase and actin regulator 1

chr1_-_126492900 2.292 ENSMUST00000161954.1
Nckap5
NCK-associated protein 5
chr5_-_73338580 2.250 ENSMUST00000087195.5
Ociad2
OCIA domain containing 2
chr18_+_61953048 2.220 ENSMUST00000051720.5
Sh3tc2
SH3 domain and tetratricopeptide repeats 2
chr12_+_86678685 2.092 ENSMUST00000021681.3
Vash1
vasohibin 1
chr10_-_71285234 2.087 ENSMUST00000020085.6
Ube2d1
ubiquitin-conjugating enzyme E2D 1
chr10_+_21993890 2.073 ENSMUST00000092673.4
Sgk1
serum/glucocorticoid regulated kinase 1
chr4_+_42158092 2.022 ENSMUST00000098122.2
Gm13306
predicted gene 13306
chr14_+_76487759 1.785 ENSMUST00000142683.1
Tsc22d1
TSC22 domain family, member 1
chr9_+_104569671 1.779 ENSMUST00000057742.8
Cpne4
copine IV
chr9_+_104569754 1.707 ENSMUST00000077190.6
Cpne4
copine IV
chr13_-_51203065 1.677 ENSMUST00000091708.4
Hist1h2al
histone cluster 1, H2al
chr12_+_100199435 1.605 ENSMUST00000110082.3
Calm1
calmodulin 1
chr17_-_33358832 1.598 ENSMUST00000054072.8
Zfp81
zinc finger protein 81
chrX_+_109095359 1.584 ENSMUST00000033598.8
Sh3bgrl
SH3-binding domain glutamic acid-rich protein like
chr11_+_87595646 1.570 ENSMUST00000134216.1
Mtmr4
myotubularin related protein 4
chr6_-_28831747 1.550 ENSMUST00000062304.5
Lrrc4
leucine rich repeat containing 4
chr10_+_84917616 1.535 ENSMUST00000038523.7
ENSMUST00000095385.3
Ric8b

resistance to inhibitors of cholinesterase 8 homolog B (C. elegans)

chr15_-_97020322 1.507 ENSMUST00000166223.1
Slc38a4
solute carrier family 38, member 4
chr10_-_127620960 1.507 ENSMUST00000121829.1
Lrp1
low density lipoprotein receptor-related protein 1
chr9_+_70679016 1.500 ENSMUST00000144537.1
Adam10
a disintegrin and metallopeptidase domain 10
chr5_-_120711927 1.379 ENSMUST00000031607.6
Dtx1
deltex 1 homolog (Drosophila)
chr3_-_122619442 1.329 ENSMUST00000162947.1
Fnbp1l
formin binding protein 1-like
chr2_+_4017727 1.316 ENSMUST00000177457.1
Frmd4a
FERM domain containing 4A
chr7_-_4445595 1.298 ENSMUST00000119485.1
Rdh13
retinol dehydrogenase 13 (all-trans and 9-cis)
chr1_+_42953106 1.292 ENSMUST00000179655.1
Gpr45
G protein-coupled receptor 45
chr10_-_127620922 1.279 ENSMUST00000118455.1
Lrp1
low density lipoprotein receptor-related protein 1
chr6_-_145250177 1.237 ENSMUST00000111710.1
ENSMUST00000155145.1
ENSMUST00000032399.5
Kras


v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog


chr11_-_95076657 1.216 ENSMUST00000001548.7
Itga3
integrin alpha 3
chr7_-_4445637 1.216 ENSMUST00000008579.7
Rdh13
retinol dehydrogenase 13 (all-trans and 9-cis)
chr10_-_127621107 1.214 ENSMUST00000049149.8
Lrp1
low density lipoprotein receptor-related protein 1
chr9_+_70678950 1.152 ENSMUST00000067880.6
Adam10
a disintegrin and metallopeptidase domain 10
chr13_+_55464237 1.151 ENSMUST00000046533.7
Prr7
proline rich 7 (synaptic)
chr4_+_109280266 1.140 ENSMUST00000102729.3
Eps15
epidermal growth factor receptor pathway substrate 15
chr11_-_95076797 1.113 ENSMUST00000145671.1
ENSMUST00000120375.1
Itga3

integrin alpha 3

chr5_+_92137896 1.023 ENSMUST00000031355.6
Uso1
USO1 vesicle docking factor
chr13_+_83732438 1.021 ENSMUST00000182701.1
C130071C03Rik
RIKEN cDNA C130071C03 gene
chr3_-_30793549 1.009 ENSMUST00000180833.1
4933429H19Rik
RIKEN cDNA 4933429H19 gene
chr12_-_118301429 1.004 ENSMUST00000026367.9
Sp4
trans-acting transcription factor 4
chr17_+_8849974 1.000 ENSMUST00000115720.1
Pde10a
phosphodiesterase 10A
chr2_+_119547697 0.978 ENSMUST00000014221.6
ENSMUST00000119172.1
Chp1

calcineurin-like EF hand protein 1

chr14_+_70077375 0.978 ENSMUST00000035908.1
Egr3
early growth response 3
chr2_+_181520485 0.968 ENSMUST00000072334.5
Dnajc5
DnaJ (Hsp40) homolog, subfamily C, member 5
chr4_+_40723084 0.939 ENSMUST00000149794.1
Dnaja1
DnaJ (Hsp40) homolog, subfamily A, member 1
chr11_-_5915124 0.889 ENSMUST00000109823.2
ENSMUST00000109822.1
Gck

glucokinase

chr17_+_6106880 0.878 ENSMUST00000149756.1
Tulp4
tubby like protein 4
chr2_-_121037048 0.871 ENSMUST00000102490.3
Epb4.2
erythrocyte protein band 4.2
chrX_-_167209149 0.864 ENSMUST00000112176.1
Tmsb4x
thymosin, beta 4, X chromosome
chr18_+_65581704 0.856 ENSMUST00000182979.1
Zfp532
zinc finger protein 532
chr8_-_71486037 0.832 ENSMUST00000093450.4
Ano8
anoctamin 8
chr2_-_45112890 0.777 ENSMUST00000076836.6
Zeb2
zinc finger E-box binding homeobox 2
chr7_+_35186370 0.760 ENSMUST00000135452.1
ENSMUST00000001854.5
Slc7a10

solute carrier family 7 (cationic amino acid transporter, y+ system), member 10

chr2_-_33086366 0.753 ENSMUST00000049618.2
Garnl3
GTPase activating RANGAP domain-like 3
chr18_-_56975333 0.740 ENSMUST00000139243.2
ENSMUST00000025488.8
C330018D20Rik

RIKEN cDNA C330018D20 gene

chr2_-_38287347 0.723 ENSMUST00000102787.3
Dennd1a
DENN/MADD domain containing 1A
chr15_-_98763195 0.698 ENSMUST00000053183.9
Arf3
ADP-ribosylation factor 3
chrX_-_8175890 0.686 ENSMUST00000143984.1
Tbc1d25
TBC1 domain family, member 25
chr5_-_135349991 0.678 ENSMUST00000044972.7
Fkbp6
FK506 binding protein 6
chr15_-_98762992 0.673 ENSMUST00000156572.1
Arf3
ADP-ribosylation factor 3
chr19_-_8880883 0.665 ENSMUST00000096253.5
AI462493
expressed sequence AI462493
chr6_+_142414012 0.661 ENSMUST00000141548.1
B230216G23Rik
RIKEN cDNA B230216G23 gene
chr9_-_106789130 0.652 ENSMUST00000046502.5
Rad54l2
RAD54 like 2 (S. cerevisiae)
chr11_+_17257558 0.612 ENSMUST00000000594.2
ENSMUST00000156784.1
C1d

C1D nuclear receptor co-repressor

chr7_-_4996044 0.581 ENSMUST00000162502.1
Zfp579
zinc finger protein 579
chr3_+_122245557 0.570 ENSMUST00000029769.7
Gclm
glutamate-cysteine ligase, modifier subunit
chr7_-_4996095 0.562 ENSMUST00000108572.1
Zfp579
zinc finger protein 579
chr15_+_84167804 0.548 ENSMUST00000045289.4
Pnpla3
patatin-like phospholipase domain containing 3
chr17_-_24644933 0.546 ENSMUST00000019684.5
Slc9a3r2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chr4_+_40722912 0.534 ENSMUST00000164233.1
ENSMUST00000137246.1
ENSMUST00000125442.1
Dnaja1


DnaJ (Hsp40) homolog, subfamily A, member 1


chr2_+_121956411 0.534 ENSMUST00000110578.1
Ctdspl2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr9_-_65021645 0.529 ENSMUST00000036615.5
Ptplad1
protein tyrosine phosphatase-like A domain containing 1
chr11_+_79993062 0.524 ENSMUST00000017692.8
ENSMUST00000163272.1
Suz12

suppressor of zeste 12 homolog (Drosophila)

chr2_-_119547627 0.481 ENSMUST00000060009.2
Exd1
exonuclease 3'-5' domain containing 1
chr11_-_74723829 0.465 ENSMUST00000102520.2
Pafah1b1
platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
chr9_-_62811592 0.456 ENSMUST00000034775.8
Fem1b
feminization 1 homolog b (C. elegans)
chr2_+_121956651 0.431 ENSMUST00000110574.1
Ctdspl2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr4_+_148602527 0.399 ENSMUST00000105701.2
ENSMUST00000052060.6
Masp2

mannan-binding lectin serine peptidase 2

chr4_+_147940859 0.388 ENSMUST00000103232.1
2510039O18Rik
RIKEN cDNA 2510039O18 gene
chr17_+_48346465 0.371 ENSMUST00000113237.3
Trem2
triggering receptor expressed on myeloid cells 2
chr6_+_145934113 0.370 ENSMUST00000032383.7
Sspn
sarcospan
chr2_-_45113255 0.361 ENSMUST00000068415.4
ENSMUST00000127520.1
Zeb2

zinc finger E-box binding homeobox 2

chr11_-_79296906 0.354 ENSMUST00000068448.2
Gm9964
predicted gene 9964
chr2_+_121955964 0.314 ENSMUST00000036647.6
Ctdspl2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr3_+_89136572 0.309 ENSMUST00000107482.3
ENSMUST00000127058.1
Pklr

pyruvate kinase liver and red blood cell

chr4_-_41697040 0.265 ENSMUST00000102962.3
ENSMUST00000084701.5
Cntfr

ciliary neurotrophic factor receptor

chr16_-_36666067 0.262 ENSMUST00000089620.4
Cd86
CD86 antigen
chr15_-_55072139 0.261 ENSMUST00000041733.7
Taf2
TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr11_+_109362771 0.260 ENSMUST00000020930.7
ENSMUST00000106702.3
Gna13

guanine nucleotide binding protein, alpha 13

chr5_+_123252087 0.247 ENSMUST00000121964.1
Wdr66
WD repeat domain 66
chr12_-_75596195 0.231 ENSMUST00000021447.7
Ppp2r5e
protein phosphatase 2, regulatory subunit B (B56), epsilon isoform
chr7_-_4445181 0.217 ENSMUST00000138798.1
Rdh13
retinol dehydrogenase 13 (all-trans and 9-cis)
chr11_-_87086752 0.204 ENSMUST00000020801.7
Smg8
smg-8 homolog, nonsense mediated mRNA decay factor (C. elegans)
chr5_-_134456702 0.169 ENSMUST00000073161.5
ENSMUST00000171794.2
ENSMUST00000111245.2
ENSMUST00000100654.3
ENSMUST00000167084.2
ENSMUST00000100652.3
ENSMUST00000100650.3
ENSMUST00000074114.5
Gtf2ird1







general transcription factor II I repeat domain-containing 1







chr17_+_48346401 0.162 ENSMUST00000024791.8
Trem2
triggering receptor expressed on myeloid cells 2
chr13_+_44840686 0.151 ENSMUST00000173906.1
Jarid2
jumonji, AT rich interactive domain 2
chr2_+_91082362 0.148 ENSMUST00000169852.1
Spi1
spleen focus forming virus (SFFV) proviral integration oncogene
chr2_+_152962485 0.137 ENSMUST00000099197.2
ENSMUST00000103155.3
Ttll9

tubulin tyrosine ligase-like family, member 9

chr1_+_134182404 0.134 ENSMUST00000153856.1
ENSMUST00000082060.3
ENSMUST00000133701.1
ENSMUST00000132873.1
Chi3l1



chitinase 3-like 1



chr6_+_29279587 0.133 ENSMUST00000167131.1
Fam71f2
family with sequence similarity 71, member F2
chr8_-_106893515 0.128 ENSMUST00000176090.1
Chtf8
CTF8, chromosome transmission fidelity factor 8
chr8_+_88174560 0.093 ENSMUST00000074808.2
9430002A10Rik
RIKEN cDNA 9430002A10 gene
chr7_+_116093296 0.090 ENSMUST00000032899.5
1110004F10Rik
RIKEN cDNA 1110004F10 gene
chr3_-_108911687 0.083 ENSMUST00000029480.8
Prpf38b
PRP38 pre-mRNA processing factor 38 (yeast) domain containing B
chr2_-_165287755 0.065 ENSMUST00000109298.1
ENSMUST00000109299.1
ENSMUST00000130393.1
ENSMUST00000017808.7
ENSMUST00000131409.1
ENSMUST00000156134.1
ENSMUST00000133961.1
Slc35c2






solute carrier family 35, member C2






chr1_-_181183739 0.055 ENSMUST00000159290.1
Wdr26
WD repeat domain 26
chr4_-_149454971 0.052 ENSMUST00000030848.2
Rbp7
retinol binding protein 7, cellular
chr7_-_141214080 0.025 ENSMUST00000026573.5
ENSMUST00000170841.1
1600016N20Rik

RIKEN cDNA 1600016N20 gene


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 13.9 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
1.2 14.0 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
1.1 29.5 GO:0048268 clathrin coat assembly(GO:0048268)
1.0 4.0 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
0.8 3.2 GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002924)
0.6 5.3 GO:0016198 axon choice point recognition(GO:0016198)
0.5 2.7 GO:0042117 monocyte activation(GO:0042117)
0.5 2.1 GO:1901491 negative regulation of lymphangiogenesis(GO:1901491)
0.5 1.0 GO:0070885 negative regulation of calcineurin-NFAT signaling cascade(GO:0070885)
0.4 4.4 GO:0032096 negative regulation of response to food(GO:0032096) negative regulation of appetite(GO:0032099)
0.3 43.7 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.3 2.3 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.3 2.7 GO:0009644 response to high light intensity(GO:0009644)
0.3 0.9 GO:0034287 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.3 5.5 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.3 21.4 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.2 1.2 GO:2000774 positive regulation of Rac protein signal transduction(GO:0035022) positive regulation of cellular senescence(GO:2000774)
0.2 5.4 GO:0045838 positive regulation of membrane potential(GO:0045838)
0.2 9.0 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
0.2 2.6 GO:1901898 regulation of cell communication by electrical coupling(GO:0010649) regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.2 2.2 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)
0.2 1.2 GO:0034587 piRNA metabolic process(GO:0034587)
0.2 0.8 GO:0015825 L-serine transport(GO:0015825)
0.2 0.5 GO:0002586 positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002582) regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002586) positive regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002588) detection of peptidoglycan(GO:0032499)
0.2 1.0 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.2 1.5 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.2 0.5 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.1 2.1 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.1 0.8 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.1 3.0 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.1 3.5 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.1 3.6 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1 9.8 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 0.7 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.1 1.5 GO:0097119 postsynaptic density protein 95 clustering(GO:0097119)
0.1 1.1 GO:1902916 positive regulation of protein polyubiquitination(GO:1902916)
0.1 0.3 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.1 0.9 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.1 0.5 GO:0051661 maintenance of centrosome location(GO:0051661)
0.1 1.0 GO:0033089 positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.1 9.9 GO:0007631 feeding behavior(GO:0007631)
0.1 3.6 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.1 3.9 GO:2001222 regulation of neuron migration(GO:2001222)
0.1 0.3 GO:0002667 lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911)
0.1 0.7 GO:1901096 regulation of autophagosome maturation(GO:1901096)
0.1 1.0 GO:0046069 cGMP catabolic process(GO:0046069)
0.1 0.4 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.1 0.5 GO:0098532 negative regulation of chemokine production(GO:0032682) histone H3-K27 trimethylation(GO:0098532)
0.1 0.3 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.0 1.5 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.3 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.0 0.5 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.0 1.4 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 4.0 GO:0030516 regulation of axon extension(GO:0030516)
0.0 1.3 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 12.8 GO:0042391 regulation of membrane potential(GO:0042391)
0.0 1.6 GO:0043388 positive regulation of DNA binding(GO:0043388)
0.0 0.1 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
0.0 0.1 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.0 1.3 GO:0006914 autophagy(GO:0006914)
0.0 2.7 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.0 5.3 GO:0006470 protein dephosphorylation(GO:0006470)
0.0 0.8 GO:0006821 chloride transport(GO:0006821)
0.0 0.6 GO:0000460 maturation of 5.8S rRNA(GO:0000460)
0.0 0.1 GO:0015786 UDP-glucose transport(GO:0015786)
0.0 4.8 GO:0007186 G-protein coupled receptor signaling pathway(GO:0007186)
0.0 0.2 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 43.7 GO:0044292 dendrite terminus(GO:0044292)
1.1 22.9 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.9 7.0 GO:0001520 outer dense fiber(GO:0001520)
0.8 4.9 GO:0044308 axonal spine(GO:0044308)
0.8 2.3 GO:0034667 integrin alpha3-beta1 complex(GO:0034667)
0.3 21.4 GO:0045335 phagocytic vesicle(GO:0045335)
0.3 2.7 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.3 5.3 GO:0031527 filopodium membrane(GO:0031527)
0.2 3.6 GO:1902711 GABA-A receptor complex(GO:1902711)
0.2 3.5 GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain(GO:0033178)
0.1 13.7 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 0.3 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.1 9.6 GO:0031225 anchored component of membrane(GO:0031225)
0.1 0.5 GO:0000235 astral microtubule(GO:0000235)
0.1 3.0 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 2.6 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 0.9 GO:0045180 basal cortex(GO:0045180)
0.1 0.2 GO:0017109 glutamate-cysteine ligase complex(GO:0017109)
0.0 1.0 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 4.3 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 0.4 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.6 GO:0000178 exosome (RNase complex)(GO:0000178)
0.0 0.7 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 29.3 GO:0031410 cytoplasmic vesicle(GO:0031410)
0.0 0.8 GO:0097440 apical dendrite(GO:0097440)
0.0 0.7 GO:0000795 synaptonemal complex(GO:0000795)
0.0 1.6 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.5 GO:0032420 stereocilium(GO:0032420)
0.0 1.5 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 1.3 GO:0005923 bicellular tight junction(GO:0005923)
0.0 0.3 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 1.0 GO:0043204 perikaryon(GO:0043204)
0.0 0.2 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 1.5 GO:0043197 dendritic spine(GO:0043197)
0.0 1.2 GO:0045211 postsynaptic membrane(GO:0045211)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 29.2 GO:0032051 clathrin light chain binding(GO:0032051)
2.7 48.6 GO:0031681 G-protein beta-subunit binding(GO:0031681)
1.3 4.0 GO:0016964 alpha-2 macroglobulin receptor activity(GO:0016964)
1.1 9.0 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.8 5.9 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.4 1.2 GO:0019002 GMP binding(GO:0019002)
0.4 1.6 GO:0031800 type 3 metabotropic glutamate receptor binding(GO:0031800)
0.3 21.4 GO:0019003 GDP binding(GO:0019003)
0.3 3.5 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.3 13.9 GO:0030507 spectrin binding(GO:0030507)
0.3 2.1 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.2 1.5 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.2 3.6 GO:0004890 GABA-A receptor activity(GO:0004890)
0.2 15.7 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.1 0.9 GO:0004340 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396)
0.1 1.0 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.1 0.5 GO:0070891 peptidoglycan binding(GO:0042834) lipoteichoic acid binding(GO:0070891)
0.1 3.1 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 0.3 GO:0004743 pyruvate kinase activity(GO:0004743)
0.1 6.4 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 2.6 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.1 0.3 GO:0001129 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129) RNA polymerase II transcription factor activity, TBP-class protein binding(GO:0001132)
0.1 0.3 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.1 2.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 0.8 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.1 3.0 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.1 2.3 GO:0043236 laminin binding(GO:0043236)
0.1 0.5 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.1 2.7 GO:0042169 SH2 domain binding(GO:0042169)
0.1 0.2 GO:0004357 glutamate-cysteine ligase activity(GO:0004357)
0.1 0.8 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.1 1.0 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.1 1.5 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 2.1 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.3 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.0 0.9 GO:0003785 actin monomer binding(GO:0003785)
0.0 1.4 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 6.4 GO:0051015 actin filament binding(GO:0051015)
0.0 0.7 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.4 GO:0001846 opsonin binding(GO:0001846)
0.0 5.4 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.9 GO:0005112 Notch binding(GO:0005112)
0.0 0.1 GO:0051525 NFAT protein binding(GO:0051525)
0.0 0.5 GO:0005123 death receptor binding(GO:0005123)
0.0 0.8 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.5 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 2.2 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 0.5 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.0 1.5 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.0 3.3 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.0 0.6 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 1.5 GO:0017124 SH3 domain binding(GO:0017124)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.2 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 4.8 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.1 6.1 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.1 5.0 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 1.4 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1 4.0 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.1 2.4 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 2.1 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.0 1.0 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.3 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 1.2 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.5 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 1.0 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 0.5 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 0.5 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 0.3 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 22.9 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.4 15.7 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.3 43.7 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.2 3.6 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.2 4.9 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.2 3.5 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.2 2.2 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1 1.4 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.1 3.0 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.1 2.1 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1 3.1 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.1 1.6 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 1.6 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 1.2 REACTOME_RAF_MAP_KINASE_CASCADE Genes involved in RAF/MAP kinase cascade
0.1 2.6 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 0.4 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 0.3 REACTOME_THROMBOXANE_SIGNALLING_THROUGH_TP_RECEPTOR Genes involved in Thromboxane signalling through TP receptor
0.1 1.5 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 1.4 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 1.2 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 1.0 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.3 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.5 REACTOME_CTLA4_INHIBITORY_SIGNALING Genes involved in CTLA4 inhibitory signaling
0.0 0.5 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.9 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+