Motif ID: Scrt2

Z-value: 1.395


Transcription factors associated with Scrt2:

Gene SymbolEntrez IDGene Name
Scrt2 ENSMUSG00000060257.2 Scrt2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Scrt2mm10_v2_chr2_+_152081529_152081624-0.742.6e-08Click!


Activity profile for motif Scrt2.

activity profile for motif Scrt2


Sorted Z-values histogram for motif Scrt2

Sorted Z-values for motif Scrt2



Network of associatons between targets according to the STRING database.



First level regulatory network of Scrt2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_34649987 16.308 ENSMUST00000099151.2
Sox2
SRY-box containing gene 2
chr7_-_25250720 12.607 ENSMUST00000116343.2
ENSMUST00000045847.8
Erf

Ets2 repressor factor

chr10_+_56377300 11.606 ENSMUST00000068581.7
Gja1
gap junction protein, alpha 1
chr15_-_98004634 11.600 ENSMUST00000131560.1
ENSMUST00000088355.5
Col2a1

collagen, type II, alpha 1

chr11_-_55419898 11.177 ENSMUST00000108858.1
ENSMUST00000141530.1
Sparc

secreted acidic cysteine rich glycoprotein

chr2_+_31950257 10.643 ENSMUST00000001920.7
Aif1l
allograft inflammatory factor 1-like
chr7_-_30973399 10.519 ENSMUST00000098553.4
ENSMUST00000147431.1
Lsr

lipolysis stimulated lipoprotein receptor

chr17_-_25570678 10.095 ENSMUST00000025003.3
ENSMUST00000173447.1
Sox8

SRY-box containing gene 8

chr2_-_164443177 9.960 ENSMUST00000017153.3
Sdc4
syndecan 4
chr7_-_30973367 9.809 ENSMUST00000108116.3
Lsr
lipolysis stimulated lipoprotein receptor
chr7_-_30973464 9.386 ENSMUST00000001279.8
Lsr
lipolysis stimulated lipoprotein receptor
chr2_+_91257323 7.483 ENSMUST00000111349.2
ENSMUST00000131711.1
Pacsin3

protein kinase C and casein kinase substrate in neurons 3

chr1_-_133424377 7.261 ENSMUST00000153799.1
Sox13
SRY-box containing gene 13
chr2_+_91256813 7.005 ENSMUST00000144394.1
ENSMUST00000028694.5
ENSMUST00000168916.1
ENSMUST00000156919.1
Pacsin3



protein kinase C and casein kinase substrate in neurons 3



chr3_-_108840477 6.438 ENSMUST00000106596.3
ENSMUST00000102621.4
Stxbp3a

syntaxin binding protein 3A

chr6_-_53820764 5.510 ENSMUST00000127748.2
Tril
TLR4 interactor with leucine-rich repeats
chrX_-_72274747 5.458 ENSMUST00000064780.3
Gabre
gamma-aminobutyric acid (GABA) A receptor, subunit epsilon
chr7_+_126847908 5.315 ENSMUST00000147257.1
ENSMUST00000139174.1
Doc2a

double C2, alpha

chr6_-_135168162 5.271 ENSMUST00000045855.7
Hebp1
heme binding protein 1
chr6_-_23839137 5.163 ENSMUST00000166458.2
ENSMUST00000142913.2
ENSMUST00000115357.1
ENSMUST00000069074.7
ENSMUST00000115361.2
ENSMUST00000018122.7
ENSMUST00000115355.1
ENSMUST00000115356.2
Cadps2







Ca2+-dependent activator protein for secretion 2







chr8_+_31187317 5.007 ENSMUST00000066173.5
ENSMUST00000161788.1
ENSMUST00000110527.2
ENSMUST00000161502.1
Fut10



fucosyltransferase 10



chr13_+_23756937 4.979 ENSMUST00000102965.2
Hist1h4b
histone cluster 1, H4b
chr13_-_81633119 4.954 ENSMUST00000126444.1
ENSMUST00000128585.1
ENSMUST00000146749.1
ENSMUST00000095585.4
Gpr98



G protein-coupled receptor 98



chr11_+_53770458 4.760 ENSMUST00000138913.1
ENSMUST00000123376.1
ENSMUST00000019043.6
ENSMUST00000133291.1
Irf1



interferon regulatory factor 1



chr4_+_98923810 4.316 ENSMUST00000030289.2
Usp1
ubiquitin specific peptidase 1
chr4_+_98923845 4.230 ENSMUST00000091358.4
Usp1
ubiquitin specific peptidase 1
chr12_-_91779129 4.037 ENSMUST00000170077.1
Ston2
stonin 2
chr9_-_27155418 3.934 ENSMUST00000167074.1
ENSMUST00000034472.8
Jam3

junction adhesion molecule 3

chr16_+_16213318 3.898 ENSMUST00000162150.1
ENSMUST00000161342.1
ENSMUST00000039408.2
Pkp2


plakophilin 2


chr5_-_137116177 3.850 ENSMUST00000054384.5
ENSMUST00000152207.1
Trim56

tripartite motif-containing 56

chr4_-_129189646 3.786 ENSMUST00000106059.1
S100pbp
S100P binding protein
chrX_+_85048309 3.751 ENSMUST00000113991.1
ENSMUST00000113992.2
Dmd

dystrophin, muscular dystrophy

chr4_+_15265798 3.749 ENSMUST00000062684.8
Tmem64
transmembrane protein 64
chr15_-_50889691 3.667 ENSMUST00000165201.2
ENSMUST00000184458.1
Trps1

trichorhinophalangeal syndrome I (human)

chr4_-_151044564 3.641 ENSMUST00000103204.4
Per3
period circadian clock 3
chr11_-_100355383 3.640 ENSMUST00000146878.2
Hap1
huntingtin-associated protein 1
chr3_-_67375163 3.600 ENSMUST00000166353.1
Gm17402
predicted gene, 17402
chr3_+_81036360 3.469 ENSMUST00000029652.3
Pdgfc
platelet-derived growth factor, C polypeptide
chr9_-_21852603 3.429 ENSMUST00000034728.7
Dock6
dedicator of cytokinesis 6
chr4_-_129189512 3.282 ENSMUST00000117965.1
ENSMUST00000106061.2
ENSMUST00000072431.6
S100pbp


S100P binding protein


chr15_-_36598019 3.116 ENSMUST00000155116.1
Pabpc1
poly(A) binding protein, cytoplasmic 1
chr12_+_78748947 3.109 ENSMUST00000082024.5
Mpp5
membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
chr12_-_40037387 3.003 ENSMUST00000146905.1
Arl4a
ADP-ribosylation factor-like 4A
chr15_+_34306666 2.989 ENSMUST00000163455.2
ENSMUST00000022947.5
Matn2

matrilin 2

chr9_+_91368970 2.686 ENSMUST00000172646.1
Zic4
zinc finger protein of the cerebellum 4
chr9_+_91368811 2.628 ENSMUST00000173054.1
Zic4
zinc finger protein of the cerebellum 4
chr6_-_120357422 2.592 ENSMUST00000032283.5
Ccdc77
coiled-coil domain containing 77
chr3_+_130180882 2.562 ENSMUST00000106353.1
ENSMUST00000080335.4
Col25a1

collagen, type XXV, alpha 1

chr4_-_129189600 2.432 ENSMUST00000117497.1
ENSMUST00000117350.1
S100pbp

S100P binding protein

chr5_-_138171248 2.431 ENSMUST00000153867.1
Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
chr12_+_113098199 2.346 ENSMUST00000009099.6
ENSMUST00000109723.1
ENSMUST00000109726.1
ENSMUST00000109727.2
ENSMUST00000069690.4
Mta1




metastasis associated 1




chr11_+_71749914 2.179 ENSMUST00000150531.1
Wscd1
WSC domain containing 1
chr6_-_120357440 2.036 ENSMUST00000112703.1
Ccdc77
coiled-coil domain containing 77
chrX_-_101085352 2.029 ENSMUST00000101362.1
ENSMUST00000073927.4
Slc7a3

solute carrier family 7 (cationic amino acid transporter, y+ system), member 3

chr16_+_44347121 1.889 ENSMUST00000050897.6
Spice1
spindle and centriole associated protein 1
chr4_+_98923908 1.888 ENSMUST00000169053.1
Usp1
ubiquitin specific peptidase 1
chrX_+_153139941 1.855 ENSMUST00000039720.4
ENSMUST00000144175.2
Rragb

Ras-related GTP binding B

chr9_+_59656368 1.839 ENSMUST00000034834.9
ENSMUST00000163694.2
Pkm

pyruvate kinase, muscle

chr6_-_120357342 1.806 ENSMUST00000163827.1
Ccdc77
coiled-coil domain containing 77
chr7_-_65370908 1.765 ENSMUST00000032729.6
Tjp1
tight junction protein 1
chr7_-_45830776 1.762 ENSMUST00000107723.2
ENSMUST00000131384.1
Grwd1

glutamate-rich WD repeat containing 1

chr2_-_170131156 1.755 ENSMUST00000063710.6
Zfp217
zinc finger protein 217
chr17_-_24533709 1.447 ENSMUST00000061764.7
Rab26
RAB26, member RAS oncogene family
chr3_-_53657339 1.436 ENSMUST00000091137.4
Frem2
Fras1 related extracellular matrix protein 2
chr12_+_65036319 1.298 ENSMUST00000120580.1
Prpf39
PRP39 pre-mRNA processing factor 39 homolog (yeast)
chr7_+_81523531 1.204 ENSMUST00000181903.1
2900076A07Rik
RIKEN cDNA 2900076A07 gene
chr14_+_54883377 1.140 ENSMUST00000022806.3
ENSMUST00000172844.1
ENSMUST00000133397.2
ENSMUST00000134077.1
Bcl2l2


Gm20521
BCL2-like 2


predicted gene 20521
chr15_-_50890041 1.092 ENSMUST00000077935.5
Trps1
trichorhinophalangeal syndrome I (human)
chr5_-_138171216 1.050 ENSMUST00000147920.1
Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
chrX_-_152769461 1.046 ENSMUST00000101141.2
ENSMUST00000062317.4
Shroom2

shroom family member 2

chr11_+_76945719 0.955 ENSMUST00000125145.1
Blmh
bleomycin hydrolase
chr19_-_4839286 0.810 ENSMUST00000037246.5
Ccs
copper chaperone for superoxide dismutase
chr7_+_107370728 0.765 ENSMUST00000137663.1
ENSMUST00000073459.5
Syt9

synaptotagmin IX

chrX_-_104671048 0.725 ENSMUST00000042070.5
Zdhhc15
zinc finger, DHHC domain containing 15
chr9_-_22117123 0.716 ENSMUST00000013966.6
Elof1
elongation factor 1 homolog (ELF1, S. cerevisiae)
chrX_-_133981765 0.686 ENSMUST00000113297.2
ENSMUST00000174542.1
ENSMUST00000033608.8
ENSMUST00000113294.1
Sytl4



synaptotagmin-like 4



chr17_-_25844514 0.675 ENSMUST00000176709.1
Rhot2
ras homolog gene family, member T2
chr18_-_3281036 0.649 ENSMUST00000049942.6
ENSMUST00000139537.1
ENSMUST00000124747.1
Crem


cAMP responsive element modulator


chr5_-_31241215 0.630 ENSMUST00000068997.3
Gm9970
predicted gene 9970
chr17_-_56183887 0.453 ENSMUST00000019723.7
D17Wsu104e
DNA segment, Chr 17, Wayne State University 104, expressed
chr17_-_25844417 0.444 ENSMUST00000176591.1
Rhot2
ras homolog gene family, member T2
chr4_+_135759705 0.413 ENSMUST00000105854.1
Myom3
myomesin family, member 3
chr5_-_137611429 0.351 ENSMUST00000031731.7
Pcolce
procollagen C-endopeptidase enhancer protein
chr2_-_32260138 0.347 ENSMUST00000002625.8
Uck1
uridine-cytidine kinase 1
chr19_-_57008187 0.322 ENSMUST00000118800.1
ENSMUST00000111584.2
ENSMUST00000122359.1
ENSMUST00000148049.1
Afap1l2



actin filament associated protein 1-like 2



chr8_-_71537402 0.314 ENSMUST00000051672.7
Bst2
bone marrow stromal cell antigen 2
chr3_+_121426495 0.287 ENSMUST00000029773.8
Cnn3
calponin 3, acidic
chr3_-_33143227 0.280 ENSMUST00000108219.1
Pex5l
peroxisomal biogenesis factor 5-like
chr9_+_94669876 0.256 ENSMUST00000033463.9
Slc9a9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr5_-_137611372 0.231 ENSMUST00000054564.6
Pcolce
procollagen C-endopeptidase enhancer protein
chr15_+_31276491 0.226 ENSMUST00000068987.5
Fam136b-ps
family with sequence similarity 136, member B, pseudogene
chr5_-_138171813 0.209 ENSMUST00000155902.1
ENSMUST00000148879.1
Mcm7

minichromosome maintenance deficient 7 (S. cerevisiae)

chr9_+_6168638 0.196 ENSMUST00000058692.7
Pdgfd
platelet-derived growth factor, D polypeptide
chr5_-_123684275 0.179 ENSMUST00000111561.1
Clip1
CAP-GLY domain containing linker protein 1
chr6_-_148831448 0.160 ENSMUST00000048418.7
Ipo8
importin 8
chr3_-_57301919 0.127 ENSMUST00000029376.8
Tm4sf1
transmembrane 4 superfamily member 1
chr5_-_123684289 0.125 ENSMUST00000111564.1
ENSMUST00000063905.5
Clip1

CAP-GLY domain containing linker protein 1

chr11_+_101070012 0.052 ENSMUST00000001802.9
Naglu
alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)
chr7_+_81523555 0.043 ENSMUST00000180385.1
ENSMUST00000180879.1
ENSMUST00000181164.1
ENSMUST00000181264.1
2900076A07Rik



RIKEN cDNA 2900076A07 gene



chr11_+_50376982 0.036 ENSMUST00000109142.1
Hnrnph1
heterogeneous nuclear ribonucleoprotein H1
chr10_-_61979073 0.033 ENSMUST00000105453.1
ENSMUST00000105452.2
ENSMUST00000105454.2
Col13a1


collagen, type XIII, alpha 1


chr6_-_85765744 0.011 ENSMUST00000050780.7
Cml3
camello-like 3
chr3_-_89101907 0.011 ENSMUST00000081848.8
Fdps
farnesyl diphosphate synthetase
chr1_+_120602405 0.001 ENSMUST00000079721.7
En1
engrailed 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
9.9 29.7 GO:1904274 tricellular tight junction assembly(GO:1904274)
3.9 11.6 GO:0003104 positive regulation of glomerular filtration(GO:0003104) cell communication by chemical coupling(GO:0010643)
3.4 10.1 GO:0072034 renal vesicle induction(GO:0072034)
2.5 12.6 GO:0010668 ectodermal cell differentiation(GO:0010668)
2.3 16.3 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
2.0 10.0 GO:1903553 positive regulation of extracellular exosome assembly(GO:1903553)
1.6 4.8 GO:2000564 CD8-positive, alpha-beta T cell proliferation(GO:0035740) negative regulation of regulatory T cell differentiation(GO:0045590) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564)
1.3 3.9 GO:0002159 desmosome assembly(GO:0002159) adherens junction maintenance(GO:0034334) intermediate filament bundle assembly(GO:0045110) maintenance of organ identity(GO:0048496)
1.3 3.8 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
1.2 3.7 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
1.1 11.6 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.9 10.4 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.9 3.5 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.8 2.3 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.7 5.2 GO:1990504 dense core granule exocytosis(GO:1990504)
0.7 3.6 GO:0032901 positive regulation of neurotrophin production(GO:0032901)
0.6 3.1 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.6 14.5 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.6 7.3 GO:0046643 regulation of gamma-delta T cell differentiation(GO:0045586) regulation of gamma-delta T cell activation(GO:0046643)
0.4 3.9 GO:0002318 myeloid progenitor cell differentiation(GO:0002318)
0.4 2.6 GO:0060385 axonogenesis involved in innervation(GO:0060385)
0.4 2.0 GO:0015822 ornithine transport(GO:0015822)
0.4 3.7 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.3 11.2 GO:0001937 negative regulation of endothelial cell proliferation(GO:0001937)
0.3 1.8 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.3 5.0 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.3 3.6 GO:0045187 regulation of circadian sleep/wake cycle, sleep(GO:0045187)
0.2 5.5 GO:0034142 toll-like receptor 4 signaling pathway(GO:0034142)
0.2 3.9 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.2 4.8 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.2 5.5 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.2 1.1 GO:0060011 Sertoli cell proliferation(GO:0060011)
0.2 4.2 GO:0008105 asymmetric protein localization(GO:0008105)
0.2 6.5 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.2 1.9 GO:1990253 cellular response to leucine starvation(GO:1990253)
0.2 5.0 GO:0097150 neuronal stem cell population maintenance(GO:0097150)
0.2 1.3 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.2 1.0 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.1 1.8 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.1 1.8 GO:0006337 nucleosome disassembly(GO:0006337)
0.1 4.4 GO:0042168 heme metabolic process(GO:0042168)
0.1 1.9 GO:0046599 regulation of centriole replication(GO:0046599)
0.1 3.0 GO:0050873 brown fat cell differentiation(GO:0050873)
0.1 0.3 GO:1901252 regulation of intracellular transport of viral material(GO:1901252)
0.1 0.3 GO:0044861 protein transport into plasma membrane raft(GO:0044861)
0.1 0.3 GO:0008655 pyrimidine-containing compound salvage(GO:0008655) pyrimidine nucleoside salvage(GO:0043097)
0.1 0.2 GO:0035696 monocyte extravasation(GO:0035696) regulation of monocyte extravasation(GO:2000437)
0.1 3.0 GO:0031102 neuron projection regeneration(GO:0031102) response to axon injury(GO:0048678)
0.1 0.7 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 1.4 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 1.1 GO:0097345 mitochondrial outer membrane permeabilization(GO:0097345)
0.0 0.3 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.0 0.3 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.7 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.3 GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742)
0.0 0.8 GO:0051353 positive regulation of oxidoreductase activity(GO:0051353)
0.0 2.8 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
5.0 29.7 GO:0061689 tricellular tight junction(GO:0061689)
2.8 11.2 GO:0031092 platelet alpha granule membrane(GO:0031092)
1.1 11.6 GO:0005916 fascia adherens(GO:0005916)
1.0 11.6 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.9 5.5 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.8 3.9 GO:0033010 paranodal junction(GO:0033010)
0.4 3.1 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.4 1.9 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.4 3.9 GO:0030057 desmosome(GO:0030057)
0.3 13.7 GO:0043034 costamere(GO:0043034)
0.2 3.7 GO:0042555 MCM complex(GO:0042555)
0.2 1.8 GO:0046581 intercellular canaliculus(GO:0046581)
0.2 5.0 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 3.1 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 23.6 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.1 1.3 GO:0000243 commitment complex(GO:0000243)
0.1 1.1 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 2.3 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 16.1 GO:0070382 exocytic vesicle(GO:0070382)
0.1 0.3 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.1 2.6 GO:0005581 collagen trimer(GO:0005581)
0.0 5.5 GO:0005814 centriole(GO:0005814)
0.0 11.6 GO:0005802 trans-Golgi network(GO:0005802)
0.0 4.4 GO:0005604 basement membrane(GO:0005604)
0.0 6.3 GO:0005884 actin filament(GO:0005884)
0.0 1.1 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 1.8 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 8.4 GO:0016607 nuclear speck(GO:0016607)
0.0 0.4 GO:0031430 M band(GO:0031430)
0.0 4.4 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.8 GO:0030667 secretory granule membrane(GO:0030667)
0.0 0.7 GO:0008023 transcription elongation factor complex(GO:0008023)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 11.6 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) gap junction channel activity involved in cell communication by electrical coupling(GO:1903763)
2.3 11.6 GO:0042289 MHC class II protein binding(GO:0042289)
2.1 29.7 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
2.0 10.0 GO:0070053 thrombospondin receptor activity(GO:0070053)
1.3 5.0 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
1.1 14.5 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.8 16.1 GO:0035198 miRNA binding(GO:0035198)
0.6 1.8 GO:0004743 pyruvate kinase activity(GO:0004743)
0.5 2.0 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.5 1.4 GO:0019002 GMP binding(GO:0019002)
0.5 3.6 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
0.4 5.5 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.3 5.5 GO:0004890 GABA-A receptor activity(GO:0004890)
0.3 3.9 GO:0045294 alpha-catenin binding(GO:0045294)
0.3 3.8 GO:0002162 dystroglycan binding(GO:0002162)
0.3 1.8 GO:0071253 connexin binding(GO:0071253)
0.2 3.7 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.2 11.2 GO:0050840 extracellular matrix binding(GO:0050840)
0.2 0.8 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.2 4.5 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.2 3.1 GO:0008266 poly(U) RNA binding(GO:0008266)
0.1 10.4 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 3.1 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 1.8 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 9.4 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 10.1 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1 3.7 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 2.3 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 5.3 GO:0020037 heme binding(GO:0020037)
0.1 1.1 GO:0051400 BH domain binding(GO:0051400)
0.1 0.3 GO:0004849 uridine kinase activity(GO:0004849)
0.1 12.6 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 4.8 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 9.7 GO:0051015 actin filament binding(GO:0051015)
0.0 2.6 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 2.2 GO:0008146 sulfotransferase activity(GO:0008146)
0.0 3.7 GO:0005178 integrin binding(GO:0005178)
0.0 0.3 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 1.3 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.7 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.3 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.0 0.7 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 13.4 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.0 0.3 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 6.0 GO:0003924 GTPase activity(GO:0003924)
0.0 0.3 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.6 GO:0016504 peptidase activator activity(GO:0016504)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 14.2 NABA_COLLAGENS Genes encoding collagen proteins
0.3 10.0 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.3 11.6 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.3 3.9 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.2 10.4 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.2 4.8 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 3.7 PID_ATR_PATHWAY ATR signaling pathway
0.1 11.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 3.4 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 1.8 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 2.3 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 2.2 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 3.7 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 1.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 10.4 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
1.0 11.6 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.4 10.0 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.3 3.5 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.3 1.8 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.2 14.8 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.2 4.8 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.2 3.7 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.1 3.8 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 5.0 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.1 3.1 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.1 9.2 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 3.1 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 2.0 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 3.9 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 3.4 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.3 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism