Motif ID: Ddit3
Z-value: 0.719

Transcription factors associated with Ddit3:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Ddit3 | ENSMUSG00000025408.9 | Ddit3 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Ddit3 | mm10_v2_chr10_+_127290774_127290803 | 0.51 | 7.5e-04 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.8 | 7.1 | GO:0036371 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
0.7 | 2.0 | GO:0034334 | adherens junction maintenance(GO:0034334) |
0.4 | 2.5 | GO:0019695 | choline metabolic process(GO:0019695) |
0.4 | 4.5 | GO:1903818 | positive regulation of voltage-gated potassium channel activity(GO:1903818) |
0.4 | 1.1 | GO:0086042 | cardiac muscle cell-cardiac muscle cell adhesion(GO:0086042) |
0.3 | 1.0 | GO:2000620 | positive regulation of histone H4-K16 acetylation(GO:2000620) |
0.3 | 2.7 | GO:0018095 | protein polyglutamylation(GO:0018095) |
0.3 | 2.9 | GO:0051901 | positive regulation of mitochondrial depolarization(GO:0051901) |
0.2 | 1.2 | GO:0018364 | peptidyl-glutamine methylation(GO:0018364) |
0.2 | 0.7 | GO:0010845 | positive regulation of reciprocal meiotic recombination(GO:0010845) |
0.2 | 0.9 | GO:0016340 | calcium-dependent cell-matrix adhesion(GO:0016340) |
0.2 | 1.8 | GO:0033184 | positive regulation of histone ubiquitination(GO:0033184) |
0.2 | 1.5 | GO:0044838 | cell quiescence(GO:0044838) |
0.2 | 0.9 | GO:0071680 | response to indole-3-methanol(GO:0071680) cellular response to indole-3-methanol(GO:0071681) |
0.2 | 2.7 | GO:0035881 | amacrine cell differentiation(GO:0035881) |
0.2 | 0.8 | GO:0099527 | postsynapse to nucleus signaling pathway(GO:0099527) |
0.2 | 0.8 | GO:0070086 | ubiquitin-dependent endocytosis(GO:0070086) |
0.2 | 1.2 | GO:0072318 | clathrin coat disassembly(GO:0072318) |
0.2 | 1.2 | GO:1903056 | positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056) |
0.2 | 0.9 | GO:1902995 | apolipoprotein A-I-mediated signaling pathway(GO:0038027) regulation of phospholipid efflux(GO:1902994) positive regulation of phospholipid efflux(GO:1902995) positive regulation of apoptotic cell clearance(GO:2000427) |
0.2 | 0.6 | GO:0070649 | meiotic chromosome movement towards spindle pole(GO:0016344) formin-nucleated actin cable assembly(GO:0070649) |
0.2 | 0.5 | GO:0051715 | cytolysis in other organism(GO:0051715) |
0.2 | 1.0 | GO:1903071 | positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071) |
0.2 | 0.6 | GO:0006751 | glutathione catabolic process(GO:0006751) |
0.2 | 0.6 | GO:0016240 | autophagosome docking(GO:0016240) |
0.1 | 0.7 | GO:2000774 | positive regulation of cellular senescence(GO:2000774) |
0.1 | 1.1 | GO:0090091 | positive regulation of axon extension involved in axon guidance(GO:0048842) positive regulation of extracellular matrix disassembly(GO:0090091) |
0.1 | 1.0 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
0.1 | 0.9 | GO:0006561 | proline biosynthetic process(GO:0006561) |
0.1 | 0.5 | GO:0033540 | fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540) |
0.1 | 0.5 | GO:0036089 | cleavage furrow formation(GO:0036089) |
0.1 | 2.8 | GO:0045475 | locomotor rhythm(GO:0045475) |
0.1 | 1.6 | GO:1990403 | embryonic brain development(GO:1990403) |
0.1 | 0.7 | GO:2000483 | negative regulation of interleukin-8 secretion(GO:2000483) |
0.1 | 1.7 | GO:0050901 | leukocyte tethering or rolling(GO:0050901) |
0.1 | 8.1 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
0.1 | 0.7 | GO:0030242 | pexophagy(GO:0030242) |
0.1 | 1.0 | GO:0090232 | positive regulation of spindle checkpoint(GO:0090232) |
0.1 | 0.5 | GO:0010747 | positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747) |
0.1 | 0.7 | GO:0061635 | regulation of protein complex stability(GO:0061635) |
0.1 | 2.1 | GO:0035025 | positive regulation of Rho protein signal transduction(GO:0035025) |
0.1 | 0.4 | GO:0045743 | positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743) |
0.1 | 0.2 | GO:0051892 | negative regulation of cardioblast differentiation(GO:0051892) |
0.1 | 0.6 | GO:0031125 | rRNA 3'-end processing(GO:0031125) |
0.1 | 0.2 | GO:0042138 | meiotic DNA double-strand break formation(GO:0042138) |
0.1 | 1.5 | GO:0031571 | mitotic G1 DNA damage checkpoint(GO:0031571) |
0.1 | 0.5 | GO:0071816 | tail-anchored membrane protein insertion into ER membrane(GO:0071816) |
0.1 | 0.2 | GO:0015882 | L-ascorbic acid transport(GO:0015882) transepithelial L-ascorbic acid transport(GO:0070904) |
0.1 | 1.3 | GO:0008090 | retrograde axonal transport(GO:0008090) |
0.1 | 0.2 | GO:0042275 | error-free postreplication DNA repair(GO:0042275) |
0.0 | 0.3 | GO:0032308 | positive regulation of prostaglandin secretion(GO:0032308) |
0.0 | 0.2 | GO:1901475 | pyruvate transmembrane transport(GO:1901475) |
0.0 | 0.6 | GO:0090141 | positive regulation of mitochondrial fission(GO:0090141) |
0.0 | 0.4 | GO:0000244 | spliceosomal tri-snRNP complex assembly(GO:0000244) |
0.0 | 0.2 | GO:0061086 | negative regulation of histone H3-K27 methylation(GO:0061086) |
0.0 | 1.3 | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184) |
0.0 | 0.2 | GO:2000258 | negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258) |
0.0 | 0.7 | GO:0051457 | maintenance of protein location in nucleus(GO:0051457) |
0.0 | 1.3 | GO:0006904 | vesicle docking involved in exocytosis(GO:0006904) |
0.0 | 0.2 | GO:1990928 | response to amino acid starvation(GO:1990928) |
0.0 | 0.6 | GO:0045956 | positive regulation of calcium ion-dependent exocytosis(GO:0045956) |
0.0 | 0.1 | GO:0055071 | cellular manganese ion homeostasis(GO:0030026) Golgi calcium ion homeostasis(GO:0032468) manganese ion homeostasis(GO:0055071) |
0.0 | 2.7 | GO:0007416 | synapse assembly(GO:0007416) |
0.0 | 0.5 | GO:0000305 | response to oxygen radical(GO:0000305) |
0.0 | 0.4 | GO:0032011 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
0.0 | 0.2 | GO:0015809 | arginine transport(GO:0015809) |
0.0 | 1.7 | GO:0043149 | contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149) |
0.0 | 0.3 | GO:0099517 | anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517) |
0.0 | 0.2 | GO:0042407 | cristae formation(GO:0042407) |
0.0 | 1.8 | GO:0006338 | chromatin remodeling(GO:0006338) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 1.3 | GO:0031673 | H zone(GO:0031673) |
0.3 | 4.6 | GO:0043083 | synaptic cleft(GO:0043083) |
0.3 | 7.1 | GO:0031430 | M band(GO:0031430) |
0.2 | 2.9 | GO:0043203 | axon hillock(GO:0043203) |
0.2 | 0.6 | GO:0097629 | extrinsic component of omegasome membrane(GO:0097629) |
0.2 | 1.0 | GO:1990037 | Lewy body core(GO:1990037) |
0.2 | 8.0 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
0.2 | 1.2 | GO:0031428 | box C/D snoRNP complex(GO:0031428) |
0.2 | 1.7 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
0.1 | 2.1 | GO:0016514 | SWI/SNF complex(GO:0016514) |
0.1 | 1.5 | GO:1990635 | proximal dendrite(GO:1990635) |
0.1 | 0.6 | GO:0071204 | histone pre-mRNA 3'end processing complex(GO:0071204) |
0.1 | 0.9 | GO:0016600 | flotillin complex(GO:0016600) |
0.1 | 0.2 | GO:0031372 | UBC13-MMS2 complex(GO:0031372) |
0.1 | 0.8 | GO:0043196 | varicosity(GO:0043196) |
0.1 | 1.1 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
0.0 | 0.7 | GO:0030008 | TRAPP complex(GO:0030008) |
0.0 | 0.8 | GO:0030914 | STAGA complex(GO:0030914) |
0.0 | 1.6 | GO:0035869 | ciliary transition zone(GO:0035869) |
0.0 | 0.9 | GO:0001891 | phagocytic cup(GO:0001891) |
0.0 | 1.3 | GO:0035145 | exon-exon junction complex(GO:0035145) |
0.0 | 1.0 | GO:0055038 | recycling endosome membrane(GO:0055038) |
0.0 | 0.4 | GO:0031045 | dense core granule(GO:0031045) |
0.0 | 0.8 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
0.0 | 0.4 | GO:0005682 | U5 snRNP(GO:0005682) |
0.0 | 0.2 | GO:0005850 | eukaryotic translation initiation factor 2 complex(GO:0005850) |
0.0 | 2.6 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
0.0 | 0.3 | GO:1904115 | axon cytoplasm(GO:1904115) |
0.0 | 0.2 | GO:0061617 | MICOS complex(GO:0061617) |
0.0 | 1.2 | GO:0005604 | basement membrane(GO:0005604) |
0.0 | 0.7 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.7 | 2.7 | GO:0070740 | tubulin-glutamic acid ligase activity(GO:0070740) |
0.6 | 2.5 | GO:0004104 | cholinesterase activity(GO:0004104) choline binding(GO:0033265) |
0.5 | 1.5 | GO:0098770 | FBXO family protein binding(GO:0098770) |
0.5 | 2.5 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
0.4 | 1.1 | GO:0035373 | chondroitin sulfate proteoglycan binding(GO:0035373) |
0.3 | 0.9 | GO:0030226 | apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556) |
0.3 | 1.8 | GO:0045322 | unmethylated CpG binding(GO:0045322) |
0.2 | 4.5 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
0.2 | 1.2 | GO:0004719 | protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719) |
0.2 | 0.9 | GO:0004735 | pyrroline-5-carboxylate reductase activity(GO:0004735) |
0.2 | 1.1 | GO:0086080 | protein binding involved in heterotypic cell-cell adhesion(GO:0086080) |
0.2 | 0.6 | GO:0071207 | histone pre-mRNA stem-loop binding(GO:0071207) |
0.2 | 1.1 | GO:0001849 | complement component C1q binding(GO:0001849) |
0.2 | 8.8 | GO:0030507 | spectrin binding(GO:0030507) |
0.1 | 0.4 | GO:0017134 | fibroblast growth factor binding(GO:0017134) |
0.1 | 0.4 | GO:0000386 | second spliceosomal transesterification activity(GO:0000386) |
0.1 | 2.9 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
0.1 | 0.6 | GO:0003839 | gamma-glutamylcyclotransferase activity(GO:0003839) |
0.1 | 0.5 | GO:0042834 | peptidoglycan binding(GO:0042834) |
0.1 | 2.1 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
0.1 | 0.5 | GO:0004791 | thioredoxin-disulfide reductase activity(GO:0004791) |
0.1 | 0.5 | GO:0016401 | palmitoyl-CoA oxidase activity(GO:0016401) |
0.1 | 1.2 | GO:0008649 | rRNA methyltransferase activity(GO:0008649) |
0.1 | 2.0 | GO:0003785 | actin monomer binding(GO:0003785) |
0.1 | 0.9 | GO:0045294 | alpha-catenin binding(GO:0045294) |
0.1 | 1.2 | GO:0005003 | ephrin receptor activity(GO:0005003) |
0.1 | 1.5 | GO:0070064 | proline-rich region binding(GO:0070064) |
0.1 | 1.7 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
0.1 | 0.2 | GO:0070890 | L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890) |
0.1 | 1.6 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
0.0 | 0.2 | GO:0050833 | pyruvate transmembrane transporter activity(GO:0050833) |
0.0 | 0.7 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
0.0 | 0.2 | GO:0015181 | arginine transmembrane transporter activity(GO:0015181) |
0.0 | 1.2 | GO:0070412 | R-SMAD binding(GO:0070412) |
0.0 | 1.3 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
0.0 | 0.8 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
0.0 | 0.5 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
0.0 | 1.0 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
0.0 | 0.3 | GO:0015929 | hexosaminidase activity(GO:0015929) |
0.0 | 0.1 | GO:0015410 | manganese-transporting ATPase activity(GO:0015410) |
0.0 | 0.7 | GO:0000062 | fatty-acyl-CoA binding(GO:0000062) |
0.0 | 1.1 | GO:0051018 | protein kinase A binding(GO:0051018) |
0.0 | 0.3 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
0.0 | 0.2 | GO:0000990 | transcription factor activity, core RNA polymerase binding(GO:0000990) |
0.0 | 1.0 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
0.0 | 0.7 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
0.0 | 0.3 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
0.0 | 0.9 | GO:0017022 | myosin binding(GO:0017022) |
0.0 | 8.3 | GO:0005509 | calcium ion binding(GO:0005509) |
0.0 | 0.8 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
0.0 | 0.4 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
0.0 | 0.5 | GO:0008028 | monocarboxylic acid transmembrane transporter activity(GO:0008028) |
0.0 | 0.8 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
0.0 | 0.5 | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding(GO:0005546) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 2.5 | PID_ATF2_PATHWAY | ATF-2 transcription factor network |
0.0 | 1.5 | PID_IL2_STAT5_PATHWAY | IL2 signaling events mediated by STAT5 |
0.0 | 1.2 | PID_EPHA_FWDPATHWAY | EPHA forward signaling |
0.0 | 0.9 | PID_ECADHERIN_KERATINOCYTE_PATHWAY | E-cadherin signaling in keratinocytes |
0.0 | 2.1 | PID_TRKR_PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
0.0 | 2.0 | PID_HEDGEHOG_GLI_PATHWAY | Hedgehog signaling events mediated by Gli proteins |
0.0 | 1.2 | PID_FAK_PATHWAY | Signaling events mediated by focal adhesion kinase |
0.0 | 1.3 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
0.0 | 0.7 | PID_MYC_PATHWAY | C-MYC pathway |
0.0 | 0.3 | PID_ANTHRAX_PATHWAY | Cellular roles of Anthrax toxin |
0.0 | 2.8 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
0.0 | 0.8 | PID_PI3KCI_AKT_PATHWAY | Class I PI3K signaling events mediated by Akt |
0.0 | 1.0 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 7.0 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
0.1 | 0.9 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
0.1 | 2.5 | REACTOME_SYNTHESIS_OF_PC | Genes involved in Synthesis of PC |
0.1 | 2.1 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
0.1 | 1.1 | REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
0.1 | 0.8 | REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
0.0 | 1.1 | REACTOME_OTHER_SEMAPHORIN_INTERACTIONS | Genes involved in Other semaphorin interactions |
0.0 | 0.9 | REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
0.0 | 1.0 | REACTOME_ACTIVATION_OF_GENES_BY_ATF4 | Genes involved in Activation of Genes by ATF4 |
0.0 | 1.5 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
0.0 | 1.2 | REACTOME_LYSOSOME_VESICLE_BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
0.0 | 1.4 | REACTOME_MRNA_3_END_PROCESSING | Genes involved in mRNA 3'-end processing |
0.0 | 0.5 | REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
0.0 | 0.5 | REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
0.0 | 0.3 | REACTOME_ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION | Genes involved in activated TAK1 mediates p38 MAPK activation |
0.0 | 0.4 | REACTOME_MRNA_SPLICING_MINOR_PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |