Motif ID: Lef1

Z-value: 1.662


Transcription factors associated with Lef1:

Gene SymbolEntrez IDGene Name
Lef1 ENSMUSG00000027985.8 Lef1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lef1mm10_v2_chr3_+_131110350_1311104710.221.6e-01Click!


Activity profile for motif Lef1.

activity profile for motif Lef1


Sorted Z-values histogram for motif Lef1

Sorted Z-values for motif Lef1



Network of associatons between targets according to the STRING database.



First level regulatory network of Lef1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_73271925 16.767 ENSMUST00000090813.5
Sp9
trans-acting transcription factor 9
chr3_-_57575760 15.271 ENSMUST00000029380.7
Wwtr1
WW domain containing transcription regulator 1
chr3_-_57575907 13.883 ENSMUST00000120977.1
Wwtr1
WW domain containing transcription regulator 1
chr2_+_70474923 13.750 ENSMUST00000100043.2
Sp5
trans-acting transcription factor 5
chr12_-_119238794 13.150 ENSMUST00000026360.8
Itgb8
integrin beta 8
chr19_-_59170978 12.306 ENSMUST00000172821.2
Vax1
ventral anterior homeobox containing gene 1
chr8_-_46294592 11.319 ENSMUST00000058636.7
Helt
helt bHLH transcription factor
chr2_+_71528657 11.094 ENSMUST00000126400.1
Dlx1
distal-less homeobox 1
chr5_+_75075464 10.472 ENSMUST00000160104.1
ENSMUST00000040477.3
Gsx2

GS homeobox 2

chr15_-_8710734 9.068 ENSMUST00000005493.7
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr2_-_26092149 8.635 ENSMUST00000114159.2
Nacc2
nucleus accumbens associated 2, BEN and BTB (POZ) domain containing
chr15_-_8710409 7.865 ENSMUST00000157065.1
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr1_+_59482133 6.956 ENSMUST00000114246.2
ENSMUST00000037105.6
Fzd7

frizzled homolog 7 (Drosophila)

chr19_+_55742242 6.238 ENSMUST00000111652.1
ENSMUST00000111649.1
ENSMUST00000111651.1
ENSMUST00000111653.1
ENSMUST00000111656.1
ENSMUST00000127233.1
ENSMUST00000153888.1
Tcf7l2






transcription factor 7 like 2, T cell specific, HMG box






chr7_-_115824699 6.028 ENSMUST00000169129.1
Sox6
SRY-box containing gene 6
chr12_+_103314944 5.752 ENSMUST00000179363.1
Fam181a
family with sequence similarity 181, member A
chr17_-_70851189 5.727 ENSMUST00000059775.8
Tgif1
TGFB-induced factor homeobox 1
chr4_-_58499398 5.552 ENSMUST00000107570.1
Lpar1
lysophosphatidic acid receptor 1
chr11_+_108920800 5.090 ENSMUST00000140821.1
Axin2
axin2
chr2_+_116067213 4.933 ENSMUST00000152412.1
G630016G05Rik
RIKEN cDNA G630016G05 gene
chr2_+_91257323 4.574 ENSMUST00000111349.2
ENSMUST00000131711.1
Pacsin3

protein kinase C and casein kinase substrate in neurons 3

chr6_+_53573364 4.494 ENSMUST00000047450.7
Creb5
cAMP responsive element binding protein 5
chr2_+_30078584 4.483 ENSMUST00000045246.7
Pkn3
protein kinase N3
chr16_+_45094036 4.428 ENSMUST00000061050.5
Ccdc80
coiled-coil domain containing 80
chr16_+_45093611 4.309 ENSMUST00000099498.2
Ccdc80
coiled-coil domain containing 80
chr13_-_113046357 4.040 ENSMUST00000022282.3
Gpx8
glutathione peroxidase 8 (putative)
chr2_+_31950257 3.763 ENSMUST00000001920.7
Aif1l
allograft inflammatory factor 1-like
chr7_-_37772868 3.752 ENSMUST00000176205.1
Zfp536
zinc finger protein 536
chr12_+_52516077 3.721 ENSMUST00000110725.1
Arhgap5
Rho GTPase activating protein 5
chr6_-_72788952 3.678 ENSMUST00000114053.2
Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
chr14_-_98169542 3.670 ENSMUST00000069334.7
ENSMUST00000071533.6
Dach1

dachshund 1 (Drosophila)

chr8_+_44950208 3.651 ENSMUST00000098796.3
Fat1
FAT tumor suppressor homolog 1 (Drosophila)
chr1_-_186705980 3.647 ENSMUST00000045288.8
Tgfb2
transforming growth factor, beta 2
chr9_+_22454290 3.597 ENSMUST00000168332.1
Gm17545
predicted gene, 17545
chr6_-_72789240 3.577 ENSMUST00000069536.5
Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
chr11_+_108920342 3.564 ENSMUST00000052915.7
Axin2
axin2
chr7_+_45216671 3.552 ENSMUST00000134420.1
Tead2
TEA domain family member 2
chr19_+_55741810 3.481 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr14_+_101840602 3.456 ENSMUST00000159314.1
Lmo7
LIM domain only 7
chr5_-_148392810 3.430 ENSMUST00000138257.1
Slc7a1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chrX_-_48034842 3.395 ENSMUST00000039026.7
Apln
apelin
chr14_+_55824795 3.383 ENSMUST00000024179.5
ENSMUST00000172271.1
Nfatc4

nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4

chr12_+_76072016 3.345 ENSMUST00000131480.1
Syne2
spectrin repeat containing, nuclear envelope 2
chr11_+_88068242 3.286 ENSMUST00000018521.4
Vezf1
vascular endothelial zinc finger 1
chr19_+_55741884 3.180 ENSMUST00000111658.3
ENSMUST00000111654.1
Tcf7l2

transcription factor 7 like 2, T cell specific, HMG box

chr15_-_50889691 3.170 ENSMUST00000165201.2
ENSMUST00000184458.1
Trps1

trichorhinophalangeal syndrome I (human)

chr13_+_104287855 3.155 ENSMUST00000065766.6
Adamts6
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6
chr10_-_13388753 3.098 ENSMUST00000105546.1
Phactr2
phosphatase and actin regulator 2
chr2_-_116067391 3.069 ENSMUST00000140185.1
2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr10_-_13388830 2.957 ENSMUST00000079698.5
Phactr2
phosphatase and actin regulator 2
chr11_+_108921648 2.944 ENSMUST00000144511.1
Axin2
axin2
chr7_+_44896125 2.922 ENSMUST00000166552.1
ENSMUST00000168207.1
Fuz

fuzzy homolog (Drosophila)

chr7_-_116038734 2.879 ENSMUST00000166877.1
Sox6
SRY-box containing gene 6
chr19_+_55742056 2.859 ENSMUST00000111659.2
Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr4_+_117849193 2.807 ENSMUST00000132043.2
ENSMUST00000169990.1
Slc6a9

solute carrier family 6 (neurotransmitter transporter, glycine), member 9

chr6_+_29735667 2.799 ENSMUST00000001812.4
Smo
smoothened homolog (Drosophila)
chr6_-_148944750 2.796 ENSMUST00000111562.1
ENSMUST00000081956.5
Fam60a

family with sequence similarity 60, member A

chr12_-_54986363 2.792 ENSMUST00000173433.1
ENSMUST00000173803.1
Baz1a
Gm20403
bromodomain adjacent to zinc finger domain 1A
predicted gene 20403
chr5_+_110330697 2.788 ENSMUST00000112481.1
Pole
polymerase (DNA directed), epsilon
chr3_-_116424007 2.786 ENSMUST00000090464.4
Cdc14a
CDC14 cell division cycle 14A
chr5_+_65131184 2.770 ENSMUST00000031089.5
ENSMUST00000101191.3
Klhl5

kelch-like 5

chr7_-_78577771 2.754 ENSMUST00000039438.7
Ntrk3
neurotrophic tyrosine kinase, receptor, type 3
chr1_-_163313661 2.735 ENSMUST00000174397.1
ENSMUST00000075805.6
ENSMUST00000027878.7
Prrx1


paired related homeobox 1


chr11_-_101785252 2.682 ENSMUST00000164750.1
ENSMUST00000107176.1
ENSMUST00000017868.6
Etv4


ets variant gene 4 (E1A enhancer binding protein, E1AF)


chr3_-_116423930 2.634 ENSMUST00000106491.2
Cdc14a
CDC14 cell division cycle 14A
chr14_-_48662740 2.573 ENSMUST00000122009.1
Otx2
orthodenticle homolog 2 (Drosophila)
chr15_-_72034202 2.512 ENSMUST00000159993.1
Col22a1
collagen, type XXII, alpha 1
chr14_+_46760526 2.503 ENSMUST00000067426.4
Cdkn3
cyclin-dependent kinase inhibitor 3
chr18_-_62756275 2.477 ENSMUST00000067450.1
ENSMUST00000048109.5
2700046A07Rik

RIKEN cDNA 2700046A07 gene

chr7_-_144939823 2.466 ENSMUST00000093962.4
Ccnd1
cyclin D1
chr2_-_101883010 2.377 ENSMUST00000154525.1
Prr5l
proline rich 5 like
chr4_+_117849361 2.328 ENSMUST00000163288.1
Slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr14_+_27039001 2.311 ENSMUST00000035336.3
Il17rd
interleukin 17 receptor D
chr1_+_74391479 2.285 ENSMUST00000027367.7
Ctdsp1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr19_-_4334001 2.222 ENSMUST00000176653.1
Kdm2a
lysine (K)-specific demethylase 2A
chr18_+_82914632 2.214 ENSMUST00000071233.6
Zfp516
zinc finger protein 516
chr15_-_78405824 2.210 ENSMUST00000058659.7
Tst
thiosulfate sulfurtransferase, mitochondrial
chr18_+_11633276 2.180 ENSMUST00000115861.2
Rbbp8
retinoblastoma binding protein 8
chr2_+_4559742 2.178 ENSMUST00000176828.1
Frmd4a
FERM domain containing 4A
chr16_-_4559720 2.170 ENSMUST00000005862.7
Tfap4
transcription factor AP4
chr4_-_34882919 2.167 ENSMUST00000098163.2
ENSMUST00000047950.5
Zfp292

zinc finger protein 292

chr14_+_101729907 2.125 ENSMUST00000100337.3
Lmo7
LIM domain only 7
chr7_-_37773555 2.124 ENSMUST00000176534.1
Zfp536
zinc finger protein 536
chr1_+_187997821 2.088 ENSMUST00000027906.6
Esrrg
estrogen-related receptor gamma
chr19_+_55895508 2.084 ENSMUST00000111646.1
Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr8_-_11312731 2.078 ENSMUST00000033898.9
Col4a1
collagen, type IV, alpha 1
chr1_+_187997835 2.055 ENSMUST00000110938.1
Esrrg
estrogen-related receptor gamma
chr12_-_54986328 2.037 ENSMUST00000038926.6
Baz1a
bromodomain adjacent to zinc finger domain 1A
chr10_-_5805412 1.932 ENSMUST00000019907.7
Fbxo5
F-box protein 5
chr3_-_141982224 1.910 ENSMUST00000029948.8
Bmpr1b
bone morphogenetic protein receptor, type 1B
chr10_-_21160925 1.908 ENSMUST00000020158.6
Myb
myeloblastosis oncogene
chr17_+_35076902 1.901 ENSMUST00000172494.1
ENSMUST00000172678.1
ENSMUST00000013910.4
Ly6g6e


lymphocyte antigen 6 complex, locus G6E


chr1_+_165788681 1.877 ENSMUST00000161971.1
ENSMUST00000178336.1
ENSMUST00000005907.5
ENSMUST00000027849.4
Cd247



CD247 antigen



chr14_+_101840501 1.838 ENSMUST00000159026.1
Lmo7
LIM domain only 7
chr6_-_99096196 1.836 ENSMUST00000175886.1
Foxp1
forkhead box P1
chr14_+_54259227 1.810 ENSMUST00000041197.7
Abhd4
abhydrolase domain containing 4
chr7_+_44896077 1.789 ENSMUST00000071207.7
ENSMUST00000166849.1
ENSMUST00000168712.1
ENSMUST00000168389.1
Fuz



fuzzy homolog (Drosophila)



chr3_-_154330543 1.784 ENSMUST00000184966.1
ENSMUST00000177846.2
Lhx8

LIM homeobox protein 8

chr11_-_102925086 1.724 ENSMUST00000021311.9
Kif18b
kinesin family member 18B
chr15_+_34238026 1.723 ENSMUST00000022867.3
Laptm4b
lysosomal-associated protein transmembrane 4B
chr11_+_117332335 1.705 ENSMUST00000106349.1
Sept9
septin 9
chr6_-_138426735 1.672 ENSMUST00000162932.1
Lmo3
LIM domain only 3
chrX_+_129749740 1.663 ENSMUST00000167619.2
ENSMUST00000037854.8
Diap2

diaphanous homolog 2 (Drosophila)

chr11_-_52282564 1.635 ENSMUST00000086844.3
Tcf7
transcription factor 7, T cell specific
chr9_-_71896047 1.627 ENSMUST00000184448.1
Tcf12
transcription factor 12
chr2_-_116065047 1.612 ENSMUST00000028639.6
ENSMUST00000102538.4
Meis2

Meis homeobox 2

chr4_-_82705735 1.600 ENSMUST00000155821.1
Nfib
nuclear factor I/B
chr17_-_79020816 1.544 ENSMUST00000168887.1
ENSMUST00000119284.1
Prkd3

protein kinase D3

chr19_-_37330613 1.539 ENSMUST00000131070.1
Ide
insulin degrading enzyme
chr1_-_165934900 1.527 ENSMUST00000069609.5
ENSMUST00000111427.2
ENSMUST00000111426.4
Pou2f1


POU domain, class 2, transcription factor 1


chrX_+_129749830 1.513 ENSMUST00000113320.2
Diap2
diaphanous homolog 2 (Drosophila)
chr5_+_77266196 1.502 ENSMUST00000113449.1
Rest
RE1-silencing transcription factor
chr18_+_34625009 1.497 ENSMUST00000166044.1
Kif20a
kinesin family member 20A
chr2_-_173276526 1.494 ENSMUST00000036248.6
Pmepa1
prostate transmembrane protein, androgen induced 1
chr7_-_37769624 1.487 ENSMUST00000175941.1
Zfp536
zinc finger protein 536
chr5_+_77265454 1.483 ENSMUST00000080359.5
Rest
RE1-silencing transcription factor
chr5_-_138170992 1.481 ENSMUST00000139983.1
Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
chr12_+_119945957 1.465 ENSMUST00000058644.8
Tmem196
transmembrane protein 196
chr4_+_107367757 1.446 ENSMUST00000139560.1
Ndc1
NDC1 transmembrane nucleoporin
chr18_+_82910863 1.442 ENSMUST00000171238.1
Zfp516
zinc finger protein 516
chr13_-_29984219 1.429 ENSMUST00000146092.1
E2f3
E2F transcription factor 3
chr11_-_88718078 1.419 ENSMUST00000092794.5
Msi2
musashi RNA-binding protein 2
chr5_-_51553896 1.405 ENSMUST00000132734.1
Ppargc1a
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
chr4_-_24430838 1.373 ENSMUST00000183964.1
RP23-35K5.2
RP23-35K5.2
chr4_+_116558056 1.367 ENSMUST00000106475.1
Gpbp1l1
GC-rich promoter binding protein 1-like 1
chr15_-_50882806 1.362 ENSMUST00000184885.1
Trps1
trichorhinophalangeal syndrome I (human)
chrX_+_6415736 1.358 ENSMUST00000143641.3
Shroom4
shroom family member 4
chr9_+_65630552 1.348 ENSMUST00000055844.8
Rbpms2
RNA binding protein with multiple splicing 2
chr18_+_69593361 1.322 ENSMUST00000114978.2
ENSMUST00000114977.1
Tcf4

transcription factor 4

chr13_+_35741313 1.312 ENSMUST00000163595.2
Cdyl
chromodomain protein, Y chromosome-like
chr4_+_108479081 1.308 ENSMUST00000155068.1
Zcchc11
zinc finger, CCHC domain containing 11
chr12_-_73113407 1.303 ENSMUST00000175693.1
Six4
sine oculis-related homeobox 4
chr7_-_78578308 1.297 ENSMUST00000039431.7
Ntrk3
neurotrophic tyrosine kinase, receptor, type 3
chr14_-_48667508 1.292 ENSMUST00000144465.1
ENSMUST00000133479.1
ENSMUST00000119070.1
ENSMUST00000152018.1
Otx2



orthodenticle homolog 2 (Drosophila)



chr1_+_59516264 1.290 ENSMUST00000114243.1
Gm973
predicted gene 973
chr5_+_47984793 1.289 ENSMUST00000170109.2
ENSMUST00000174421.1
ENSMUST00000173702.1
ENSMUST00000173107.1
Slit2



slit homolog 2 (Drosophila)



chr1_+_165788746 1.288 ENSMUST00000161559.2
Cd247
CD247 antigen
chr17_+_8182247 1.279 ENSMUST00000161898.1
Fgfr1op
Fgfr1 oncogene partner
chr3_-_51560816 1.259 ENSMUST00000037141.7
Setd7
SET domain containing (lysine methyltransferase) 7
chr12_-_98737405 1.232 ENSMUST00000170188.1
Ptpn21
protein tyrosine phosphatase, non-receptor type 21
chr8_-_84773381 1.225 ENSMUST00000109764.1
Nfix
nuclear factor I/X
chr3_+_89215192 1.217 ENSMUST00000142051.1
ENSMUST00000119084.1
Thbs3

thrombospondin 3

chr7_+_73375494 1.212 ENSMUST00000094312.5
ENSMUST00000119206.1
Rgma

RGM domain family, member A

chr5_-_138171248 1.209 ENSMUST00000153867.1
Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
chr12_+_76370266 1.193 ENSMUST00000042779.3
Zbtb1
zinc finger and BTB domain containing 1
chr3_-_75956888 1.188 ENSMUST00000038563.7
ENSMUST00000167078.1
ENSMUST00000117242.1
Golim4


golgi integral membrane protein 4


chr14_-_101729690 1.181 ENSMUST00000066461.3
Gm9922
predicted gene 9922
chr3_+_131110350 1.169 ENSMUST00000066849.6
ENSMUST00000106341.2
ENSMUST00000029611.7
Lef1


lymphoid enhancer binding factor 1


chr5_+_47984571 1.169 ENSMUST00000174313.1
Slit2
slit homolog 2 (Drosophila)
chr6_+_15185203 1.145 ENSMUST00000154448.1
Foxp2
forkhead box P2
chr2_-_173276144 1.143 ENSMUST00000139306.1
Pmepa1
prostate transmembrane protein, androgen induced 1
chr10_+_94036001 1.133 ENSMUST00000020208.4
Fgd6
FYVE, RhoGEF and PH domain containing 6
chr2_-_172370506 1.128 ENSMUST00000109139.1
ENSMUST00000028997.7
ENSMUST00000109140.3
Aurka


aurora kinase A


chr3_-_141931523 1.120 ENSMUST00000106232.1
Bmpr1b
bone morphogenetic protein receptor, type 1B
chr3_-_88762244 1.113 ENSMUST00000183267.1
Syt11
synaptotagmin XI
chr17_-_51810866 1.103 ENSMUST00000176669.1
Satb1
special AT-rich sequence binding protein 1
chr3_-_116968827 1.102 ENSMUST00000119557.1
Palmd
palmdelphin
chr3_+_89215170 1.100 ENSMUST00000029682.4
Thbs3
thrombospondin 3
chr3_-_97297778 1.099 ENSMUST00000181368.1
Gm17608
predicted gene, 17608
chr15_-_13173607 1.095 ENSMUST00000036439.4
Cdh6
cadherin 6
chr2_+_96318014 1.094 ENSMUST00000135431.1
ENSMUST00000162807.2
Lrrc4c

leucine rich repeat containing 4C

chr9_+_17030045 1.089 ENSMUST00000164523.2
Gm5611
predicted gene 5611
chr9_-_48835932 1.069 ENSMUST00000093852.3
Zbtb16
zinc finger and BTB domain containing 16
chr18_+_4921662 1.060 ENSMUST00000143254.1
Svil
supervillin
chr8_+_11312805 1.035 ENSMUST00000033899.7
Col4a2
collagen, type IV, alpha 2
chr4_+_116557658 1.016 ENSMUST00000030460.8
Gpbp1l1
GC-rich promoter binding protein 1-like 1
chr18_+_34624621 1.015 ENSMUST00000167161.1
Kif20a
kinesin family member 20A
chr1_+_135232045 0.993 ENSMUST00000110798.3
Gm4204
predicted gene 4204
chr16_+_43508118 0.991 ENSMUST00000114690.1
Zbtb20
zinc finger and BTB domain containing 20
chr12_+_80518990 0.987 ENSMUST00000021558.6
Galnt16
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 16
chr5_-_138155694 0.984 ENSMUST00000132318.1
ENSMUST00000049393.8
Zfp113

zinc finger protein 113

chr2_+_92185438 0.959 ENSMUST00000128781.2
Phf21a
PHD finger protein 21A
chr10_-_86011833 0.955 ENSMUST00000105304.1
ENSMUST00000061699.5
Bpifc

BPI fold containing family C

chr8_+_108714644 0.949 ENSMUST00000043896.8
Zfhx3
zinc finger homeobox 3
chr6_+_83137089 0.948 ENSMUST00000121093.1
ENSMUST00000087938.4
Rtkn

rhotekin

chr19_-_34877880 0.947 ENSMUST00000112460.1
Pank1
pantothenate kinase 1
chr11_-_47379405 0.944 ENSMUST00000077221.5
Sgcd
sarcoglycan, delta (dystrophin-associated glycoprotein)
chr9_+_110132015 0.924 ENSMUST00000088716.5
ENSMUST00000111969.1
ENSMUST00000035057.7
ENSMUST00000111966.1
ENSMUST00000111968.1
Smarcc1




SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1




chr12_+_29938036 0.921 ENSMUST00000122328.1
ENSMUST00000118321.1
Pxdn

peroxidasin homolog (Drosophila)

chrX_+_143518671 0.917 ENSMUST00000134402.1
Pak3
p21 protein (Cdc42/Rac)-activated kinase 3
chr16_-_56024628 0.909 ENSMUST00000119981.1
ENSMUST00000096021.3
Pcnp

PEST proteolytic signal containing nuclear protein

chr16_+_70314057 0.900 ENSMUST00000171132.1
Gbe1
glucan (1,4-alpha-), branching enzyme 1
chr3_+_86084434 0.897 ENSMUST00000107664.2
Sh3d19
SH3 domain protein D19
chr13_-_105054895 0.895 ENSMUST00000063551.5
Rgs7bp
regulator of G-protein signalling 7 binding protein
chr9_+_37367354 0.895 ENSMUST00000051839.7
Hepacam
hepatocyte cell adhesion molecule
chr16_+_78930940 0.889 ENSMUST00000114216.1
ENSMUST00000069148.6
ENSMUST00000023568.7
Chodl


chondrolectin


chr14_+_25607797 0.881 ENSMUST00000160229.1
Zmiz1
zinc finger, MIZ-type containing 1
chr2_-_180889660 0.872 ENSMUST00000137629.1
Gm14342
predicted gene 14342
chr10_+_53596936 0.844 ENSMUST00000020004.6
Asf1a
ASF1 anti-silencing function 1 homolog A (S. cerevisiae)
chr6_-_124813065 0.834 ENSMUST00000149610.2
Tpi1
triosephosphate isomerase 1
chrX_+_9272756 0.823 ENSMUST00000015486.6
Xk
Kell blood group precursor (McLeod phenotype) homolog
chr4_+_8691303 0.820 ENSMUST00000051558.3
Chd7
chromodomain helicase DNA binding protein 7
chrX_+_99975570 0.818 ENSMUST00000113779.1
ENSMUST00000113776.1
ENSMUST00000113775.1
ENSMUST00000113780.1
ENSMUST00000113778.1
ENSMUST00000113781.1
ENSMUST00000113783.1
ENSMUST00000071453.2
ENSMUST00000113777.1
Eda








ectodysplasin-A








chr13_-_104109576 0.801 ENSMUST00000109315.3
Nln
neurolysin (metallopeptidase M3 family)
chr6_+_17463927 0.796 ENSMUST00000115442.1
Met
met proto-oncogene
chr11_-_120598346 0.792 ENSMUST00000026125.2
Alyref
Aly/REF export factor
chr4_+_86053887 0.791 ENSMUST00000107178.2
ENSMUST00000048885.5
ENSMUST00000141889.1
ENSMUST00000120678.1
Adamtsl1



ADAMTS-like 1



chr2_-_60125651 0.788 ENSMUST00000112550.1
Baz2b
bromodomain adjacent to zinc finger domain, 2B
chr12_+_18514738 0.786 ENSMUST00000177778.1
ENSMUST00000063216.4
5730507C01Rik

RIKEN cDNA 5730507C01 gene

chr7_-_73541738 0.782 ENSMUST00000169922.2
Chd2
chromodomain helicase DNA binding protein 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 16.9 GO:0043490 malate-aspartate shuttle(GO:0043490)
4.2 29.2 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
3.9 11.6 GO:0061181 regulation of chondrocyte development(GO:0061181)
3.7 11.1 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
2.4 7.3 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
2.3 18.3 GO:0048625 myoblast fate commitment(GO:0048625)
1.7 7.0 GO:2000383 regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384)
1.7 5.1 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
1.6 4.7 GO:2000314 negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314)
1.4 5.6 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
1.4 10.8 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406)
1.4 4.1 GO:0048687 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
1.3 6.5 GO:0060242 contact inhibition(GO:0060242)
1.2 3.6 GO:1902256 endocardial cushion fusion(GO:0003274) apoptotic process involved in outflow tract morphogenesis(GO:0003275) atrial septum primum morphogenesis(GO:0003289) positive regulation of catagen(GO:0051795) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256)
1.1 3.4 GO:2000297 negative regulation of synapse maturation(GO:2000297)
1.1 2.1 GO:0098528 skeletal muscle fiber differentiation(GO:0098528)
1.0 3.9 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.9 2.8 GO:0045004 DNA replication proofreading(GO:0045004)
0.9 10.5 GO:0048853 forebrain morphogenesis(GO:0048853)
0.8 11.9 GO:2000739 regulation of mesenchymal stem cell differentiation(GO:2000739)
0.8 2.5 GO:1904020 regulation of G-protein coupled receptor internalization(GO:1904020)
0.8 2.5 GO:0021972 corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260)
0.8 1.6 GO:0048619 embryonic hindgut morphogenesis(GO:0048619)
0.8 3.9 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.8 3.1 GO:0007056 spindle assembly involved in female meiosis(GO:0007056)
0.8 12.2 GO:0001573 ganglioside metabolic process(GO:0001573)
0.8 3.0 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.8 12.1 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.7 11.2 GO:0097154 GABAergic neuron differentiation(GO:0097154)
0.7 2.2 GO:0035928 rRNA import into mitochondrion(GO:0035928)
0.7 2.7 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.7 8.6 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.7 2.0 GO:0061153 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.6 14.4 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.5 5.4 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.5 2.6 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.5 0.5 GO:0071336 regulation of hair follicle cell proliferation(GO:0071336) positive regulation of hair follicle cell proliferation(GO:0071338)
0.5 1.5 GO:0045204 MAPK export from nucleus(GO:0045204)
0.4 2.2 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.4 1.6 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.4 1.5 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.4 1.1 GO:1990927 negative regulation of membrane invagination(GO:1905154) calcium ion regulated lysosome exocytosis(GO:1990927)
0.4 1.1 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.4 1.1 GO:1900039 positive regulation of cellular response to hypoxia(GO:1900039)
0.4 2.5 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.4 1.4 GO:2000182 regulation of progesterone biosynthetic process(GO:2000182)
0.3 3.7 GO:0002053 positive regulation of mesenchymal cell proliferation(GO:0002053)
0.3 2.3 GO:0060346 bone trabecula formation(GO:0060346)
0.3 3.3 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.3 0.9 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.3 1.5 GO:0089700 protein kinase D signaling(GO:0089700)
0.3 0.6 GO:2001160 regulation of histone H3-K79 methylation(GO:2001160)
0.3 2.7 GO:0048664 neuron fate determination(GO:0048664)
0.3 1.2 GO:0002572 pro-T cell differentiation(GO:0002572)
0.3 2.1 GO:0061304 retinal blood vessel morphogenesis(GO:0061304)
0.3 1.4 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.3 6.7 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.3 0.8 GO:0019405 alditol catabolic process(GO:0019405) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.3 2.2 GO:0033184 positive regulation of histone ubiquitination(GO:0033184)
0.3 0.8 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.3 2.2 GO:0043922 negative regulation by host of viral transcription(GO:0043922)
0.3 1.9 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.3 2.4 GO:0038203 TORC2 signaling(GO:0038203)
0.3 4.5 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.2 0.7 GO:0097401 synaptic vesicle lumen acidification(GO:0097401)
0.2 2.3 GO:0061470 interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619)
0.2 3.4 GO:0015809 arginine transport(GO:0015809)
0.2 1.5 GO:0010992 ubiquitin homeostasis(GO:0010992)
0.2 0.8 GO:0031133 regulation of axon diameter(GO:0031133)
0.2 1.4 GO:0007296 vitellogenesis(GO:0007296)
0.2 3.9 GO:0030903 notochord development(GO:0030903)
0.2 1.9 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.2 0.5 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.2 0.6 GO:0050904 diapedesis(GO:0050904)
0.2 1.3 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.1 1.3 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.1 0.4 GO:0045578 negative regulation of B cell differentiation(GO:0045578)
0.1 0.4 GO:0071579 regulation of zinc ion transport(GO:0071579)
0.1 7.6 GO:0060612 adipose tissue development(GO:0060612)
0.1 2.5 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.1 0.6 GO:0051866 general adaptation syndrome(GO:0051866)
0.1 0.6 GO:0003097 renal water transport(GO:0003097) renal water absorption(GO:0070295)
0.1 0.1 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.1 3.2 GO:0070207 protein homotrimerization(GO:0070207)
0.1 1.3 GO:0042118 endothelial cell activation(GO:0042118)
0.1 1.0 GO:2000794 regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000794)
0.1 0.6 GO:2000325 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966) regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.1 4.1 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.1 13.2 GO:0030326 embryonic limb morphogenesis(GO:0030326) embryonic appendage morphogenesis(GO:0035113)
0.1 1.4 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.1 0.7 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.1 0.5 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.1 0.5 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.1 0.6 GO:0034773 histone H4-K20 trimethylation(GO:0034773) establishment of Sertoli cell barrier(GO:0097368)
0.1 0.8 GO:0010587 miRNA catabolic process(GO:0010587)
0.1 0.8 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.1 0.3 GO:1904207 chemokine (C-C motif) ligand 2 secretion(GO:0035926) regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.1 0.3 GO:1904245 regulation of polynucleotide adenylyltransferase activity(GO:1904245)
0.1 0.7 GO:0016576 histone dephosphorylation(GO:0016576)
0.1 3.7 GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.1 1.7 GO:0001967 suckling behavior(GO:0001967)
0.1 2.4 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.1 1.7 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.1 1.1 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.1 1.2 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.1 8.7 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.1 1.1 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.1 1.0 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.1 0.3 GO:0033580 protein glycosylation at cell surface(GO:0033575) protein galactosylation at cell surface(GO:0033580) protein galactosylation(GO:0042125)
0.1 0.4 GO:0097473 cellular response to light intensity(GO:0071484) cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473)
0.1 0.9 GO:0006337 nucleosome disassembly(GO:0006337)
0.1 0.9 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.1 0.3 GO:1902775 mitochondrial large ribosomal subunit assembly(GO:1902775)
0.1 0.7 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.1 0.9 GO:0048642 negative regulation of skeletal muscle tissue development(GO:0048642)
0.1 3.0 GO:0060976 coronary vasculature development(GO:0060976)
0.1 0.4 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.1 0.9 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.0 0.2 GO:0035547 interferon-beta secretion(GO:0035546) regulation of interferon-beta secretion(GO:0035547) positive regulation of interferon-beta secretion(GO:0035549) CRD-mediated mRNA stabilization(GO:0070934)
0.0 0.3 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.0 2.7 GO:0001885 endothelial cell development(GO:0001885)
0.0 1.3 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.2 GO:0071442 N-terminal peptidyl-lysine acetylation(GO:0018076) regulation of histone H3-K14 acetylation(GO:0071440) positive regulation of histone H3-K14 acetylation(GO:0071442)
0.0 1.6 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.0 0.2 GO:0070314 G1 to G0 transition(GO:0070314)
0.0 4.8 GO:0006261 DNA-dependent DNA replication(GO:0006261)
0.0 0.3 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.0 0.1 GO:0003263 cardioblast proliferation(GO:0003263) regulation of cardioblast proliferation(GO:0003264) vitamin D receptor signaling pathway(GO:0070561) positive regulation of cell proliferation involved in heart morphogenesis(GO:2000138)
0.0 0.3 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 1.0 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 0.8 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)
0.0 0.2 GO:0035881 amacrine cell differentiation(GO:0035881)
0.0 0.1 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.0 1.0 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.0 1.3 GO:0045638 negative regulation of myeloid cell differentiation(GO:0045638)
0.0 2.3 GO:0007050 cell cycle arrest(GO:0007050)
0.0 0.2 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.0 0.4 GO:0050873 brown fat cell differentiation(GO:0050873)
0.0 0.2 GO:0060712 spongiotrophoblast layer development(GO:0060712)
0.0 0.2 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.0 0.2 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
0.0 0.9 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0 0.6 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
0.0 1.1 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.2 GO:0006465 signal peptide processing(GO:0006465)
0.0 2.0 GO:0090132 epithelial cell migration(GO:0010631) tissue migration(GO:0090130) epithelium migration(GO:0090132)
0.0 0.1 GO:0070914 UV-damage excision repair(GO:0070914)
0.0 0.5 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 0.3 GO:0097352 autophagosome maturation(GO:0097352)
0.0 0.1 GO:0061436 establishment of skin barrier(GO:0061436)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 18.3 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
1.2 4.8 GO:0008623 CHRAC(GO:0008623)
1.2 3.6 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.8 3.2 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.6 3.1 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.6 1.8 GO:0042585 germinal vesicle(GO:0042585)
0.6 1.8 GO:0001674 female germ cell nucleus(GO:0001674)
0.6 1.2 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.6 13.1 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.6 2.8 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.5 8.5 GO:0005614 interstitial matrix(GO:0005614)
0.5 3.9 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.4 2.8 GO:0016580 Sin3 complex(GO:0016580)
0.4 8.6 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.3 1.7 GO:0000235 astral microtubule(GO:0000235)
0.2 0.9 GO:0016012 sarcoglycan complex(GO:0016012)
0.2 2.8 GO:0044294 dendritic growth cone(GO:0044294)
0.2 3.3 GO:0042555 MCM complex(GO:0042555)
0.2 11.5 GO:0017053 transcriptional repressor complex(GO:0017053)
0.2 1.1 GO:0044305 calyx of Held(GO:0044305)
0.2 72.4 GO:0005667 transcription factor complex(GO:0005667)
0.2 0.6 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.2 5.8 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 2.4 GO:0031932 TORC2 complex(GO:0031932)
0.1 1.1 GO:0032009 early phagosome(GO:0032009)
0.1 1.5 GO:0031597 cytosolic proteasome complex(GO:0031597)
0.1 1.7 GO:0031105 septin complex(GO:0031105)
0.1 1.4 GO:0016460 myosin II complex(GO:0016460)
0.1 17.2 GO:0043197 dendritic spine(GO:0043197)
0.1 1.6 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 0.9 GO:0044666 MLL3/4 complex(GO:0044666)
0.1 0.3 GO:0033269 internode region of axon(GO:0033269)
0.1 0.7 GO:0042581 specific granule(GO:0042581)
0.1 0.2 GO:0005726 perichromatin fibrils(GO:0005726)
0.1 0.9 GO:0071564 npBAF complex(GO:0071564)
0.0 0.5 GO:0030057 desmosome(GO:0030057)
0.0 4.7 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.2 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 4.1 GO:0072686 mitotic spindle(GO:0072686)
0.0 1.7 GO:1990391 DNA repair complex(GO:1990391)
0.0 1.4 GO:0097440 apical dendrite(GO:0097440)
0.0 1.5 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.4 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 2.7 GO:0005604 basement membrane(GO:0005604)
0.0 0.7 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.1 GO:0030289 protein phosphatase 4 complex(GO:0030289)
0.0 0.2 GO:0005787 signal peptidase complex(GO:0005787)
0.0 1.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.4 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 2.0 GO:0030175 filopodium(GO:0030175)
0.0 1.6 GO:0030118 clathrin coat(GO:0030118)
0.0 1.2 GO:0005871 kinesin complex(GO:0005871)
0.0 0.3 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 0.2 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.6 GO:0030027 lamellipodium(GO:0030027)
0.0 0.1 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0 0.2 GO:0005581 collagen trimer(GO:0005581)
0.0 1.0 GO:0005844 polysome(GO:0005844)
0.0 0.3 GO:0031430 M band(GO:0031430)
0.0 2.2 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.1 GO:0005677 chromatin silencing complex(GO:0005677)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 16.9 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
1.9 13.1 GO:1990430 extracellular matrix protein binding(GO:1990430)
1.5 12.3 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.9 2.8 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.9 19.5 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.9 3.6 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.8 4.1 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.8 2.4 GO:0030549 acetylcholine receptor activator activity(GO:0030549)
0.8 5.6 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.8 2.3 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.6 5.1 GO:0005283 sodium:amino acid symporter activity(GO:0005283)
0.6 11.1 GO:0070411 I-SMAD binding(GO:0070411)
0.6 2.8 GO:0005113 patched binding(GO:0005113)
0.5 3.0 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.5 1.9 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.5 1.9 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.5 3.7 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.4 2.2 GO:0004792 thiosulfate sulfurtransferase activity(GO:0004792)
0.4 3.4 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.4 3.4 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.4 5.0 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.4 5.7 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.4 2.2 GO:0045322 unmethylated CpG binding(GO:0045322)
0.3 5.7 GO:0070410 co-SMAD binding(GO:0070410)
0.3 1.3 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.3 8.7 GO:0001968 fibronectin binding(GO:0001968)
0.3 1.3 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.3 4.1 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.3 4.0 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.3 7.0 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.3 1.9 GO:1990948 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.3 1.3 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.3 2.3 GO:0008420 CTD phosphatase activity(GO:0008420)
0.3 6.0 GO:0004697 protein kinase C activity(GO:0004697)
0.2 7.4 GO:0042805 actinin binding(GO:0042805)
0.2 1.1 GO:0035174 histone serine kinase activity(GO:0035174)
0.2 0.9 GO:0003844 1,4-alpha-glucan branching enzyme activity(GO:0003844)
0.2 3.6 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.2 0.8 GO:0070012 oligopeptidase activity(GO:0070012)
0.2 4.8 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.2 0.9 GO:0004594 pantothenate kinase activity(GO:0004594)
0.2 8.6 GO:0004407 histone deacetylase activity(GO:0004407)
0.2 0.7 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.2 8.6 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.2 1.4 GO:0043559 insulin binding(GO:0043559)
0.2 3.4 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.2 4.0 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.2 32.5 GO:0003714 transcription corepressor activity(GO:0003714)
0.2 1.1 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.2 22.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 0.4 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.1 2.1 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 0.5 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.1 3.9 GO:0070888 E-box binding(GO:0070888)
0.1 0.9 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 2.6 GO:0070412 R-SMAD binding(GO:0070412)
0.1 7.1 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.1 0.8 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 1.2 GO:1990459 transferrin receptor binding(GO:1990459)
0.1 0.6 GO:0015288 porin activity(GO:0015288)
0.1 0.5 GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.1 3.5 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 3.7 GO:0042169 SH2 domain binding(GO:0042169)
0.1 0.8 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.1 2.0 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 40.4 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.1 1.4 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 0.3 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.1 0.7 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.1 1.2 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 8.8 GO:0051015 actin filament binding(GO:0051015)
0.0 0.3 GO:0047276 N-acetyllactosaminide 3-alpha-galactosyltransferase activity(GO:0047276)
0.0 0.9 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.1 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.0 0.9 GO:0070064 proline-rich region binding(GO:0070064)
0.0 14.5 GO:0003682 chromatin binding(GO:0003682)
0.0 0.2 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.8 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.3 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.1 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.0 0.3 GO:0019213 deacetylase activity(GO:0019213)
0.0 0.5 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 1.0 GO:0030332 cyclin binding(GO:0030332)
0.0 1.7 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.2 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 0.6 GO:0019903 protein phosphatase binding(GO:0019903)
0.0 1.1 GO:0030276 clathrin binding(GO:0030276)
0.0 0.1 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.0 0.8 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.2 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 1.8 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 0.2 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 1.1 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 0.4 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 13.1 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.5 55.0 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.4 3.6 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.2 7.0 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.2 4.5 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.1 2.0 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.1 13.0 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 6.5 PID_BMP_PATHWAY BMP receptor signaling
0.1 2.5 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.1 3.3 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events
0.1 3.1 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.1 2.7 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 5.6 PID_PLK1_PATHWAY PLK1 signaling events
0.1 4.1 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.1 1.8 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 3.0 NABA_COLLAGENS Genes encoding collagen proteins
0.1 2.9 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.1 5.3 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.1 2.3 PID_SHP2_PATHWAY SHP2 signaling
0.1 2.7 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.7 PID_ATR_PATHWAY ATR signaling pathway
0.0 0.4 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 2.2 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 2.1 PID_E2F_PATHWAY E2F transcription factor network
0.0 0.7 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.0 1.2 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.8 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.0 3.2 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.1 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 1.1 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 0.7 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 2.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.5 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 32.9 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.5 3.2 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.5 5.1 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.5 2.3 REACTOME_SIGNALING_BY_FGFR Genes involved in Signaling by FGFR
0.4 19.0 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.3 4.8 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.2 3.3 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.2 2.3 REACTOME_SIGNALING_BY_PDGF Genes involved in Signaling by PDGF
0.2 2.8 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.2 15.0 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.2 2.5 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.2 1.4 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.2 1.1 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 3.9 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 5.2 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 1.9 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 3.0 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.1 2.6 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.1 3.0 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 8.3 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 0.7 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 0.6 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 3.1 REACTOME_RNA_POL_III_TRANSCRIPTION Genes involved in RNA Polymerase III Transcription
0.1 4.2 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 0.9 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 1.6 REACTOME_KINESINS Genes involved in Kinesins
0.1 6.1 REACTOME_MEIOSIS Genes involved in Meiosis
0.1 5.5 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.1 0.4 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.0 1.3 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 1.9 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 0.6 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.0 1.9 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.5 REACTOME_ACYL_CHAIN_REMODELLING_OF_PC Genes involved in Acyl chain remodelling of PC
0.0 1.1 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.1 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 1.2 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 0.5 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 2.2 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.4 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.8 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.9 REACTOME_GLUCOSE_METABOLISM Genes involved in Glucose metabolism
0.0 1.6 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.4 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 1.1 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.0 0.8 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.2 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.0 0.9 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis