Motif ID: Nkx2-1

Z-value: 0.671


Transcription factors associated with Nkx2-1:

Gene SymbolEntrez IDGene Name
Nkx2-1 ENSMUSG00000001496.9 Nkx2-1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-1mm10_v2_chr12_-_56536895_565369370.525.7e-04Click!


Activity profile for motif Nkx2-1.

activity profile for motif Nkx2-1


Sorted Z-values histogram for motif Nkx2-1

Sorted Z-values for motif Nkx2-1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_89688196 5.659 ENSMUST00000052478.2
Dmrta1
doublesex and mab-3 related transcription factor like family A1
chr12_+_103314944 5.547 ENSMUST00000179363.1
Fam181a
family with sequence similarity 181, member A
chr8_-_46294592 5.202 ENSMUST00000058636.7
Helt
helt bHLH transcription factor
chr15_-_88978958 3.867 ENSMUST00000042594.6
ENSMUST00000109368.1
Mlc1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

chr19_+_44493472 3.852 ENSMUST00000041163.4
Wnt8b
wingless related MMTV integration site 8b
chr11_+_117849223 3.540 ENSMUST00000081387.4
Birc5
baculoviral IAP repeat-containing 5
chr14_-_47411666 3.528 ENSMUST00000111778.3
Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr16_+_48994185 2.830 ENSMUST00000117994.1
ENSMUST00000048374.5
C330027C09Rik

RIKEN cDNA C330027C09 gene

chr11_+_117849286 2.735 ENSMUST00000093906.4
Birc5
baculoviral IAP repeat-containing 5
chrX_+_100730178 2.646 ENSMUST00000113744.1
Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chr2_-_57114970 2.644 ENSMUST00000028166.2
Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr10_+_88091070 2.416 ENSMUST00000048621.7
Pmch
pro-melanin-concentrating hormone
chr14_+_75455957 2.313 ENSMUST00000164848.1
Siah3
seven in absentia homolog 3 (Drosophila)
chr4_-_141874879 2.180 ENSMUST00000036854.3
Efhd2
EF hand domain containing 2
chr1_+_97024681 1.995 ENSMUST00000054664.7
Gm6430
predicted gene 6430
chr12_+_91400990 1.994 ENSMUST00000021346.7
ENSMUST00000021343.6
Tshr

thyroid stimulating hormone receptor

chr4_-_9643638 1.946 ENSMUST00000108333.1
ENSMUST00000108334.1
ENSMUST00000108335.1
ENSMUST00000152526.1
ENSMUST00000103004.3
Asph




aspartate-beta-hydroxylase




chr2_+_121506715 1.785 ENSMUST00000028676.5
Wdr76
WD repeat domain 76
chr2_+_121506748 1.781 ENSMUST00000099473.3
ENSMUST00000110602.2
Wdr76

WD repeat domain 76

chr11_-_78550777 1.632 ENSMUST00000103242.4
Tmem97
transmembrane protein 97
chr11_+_63133068 1.462 ENSMUST00000108700.1
Pmp22
peripheral myelin protein 22
chr1_-_181842334 1.438 ENSMUST00000005003.6
Lbr
lamin B receptor
chr11_+_94741782 1.434 ENSMUST00000021240.6
Cdc34-ps
cell division cycle 34 homolog, pseudogene (S. cerevisiae)
chr4_+_98923845 1.409 ENSMUST00000091358.4
Usp1
ubiquitin specific peptidase 1
chr4_-_21685782 1.379 ENSMUST00000076206.4
Prdm13
PR domain containing 13
chr17_+_47737030 1.363 ENSMUST00000086932.3
Tfeb
transcription factor EB
chr1_+_75450699 1.351 ENSMUST00000037708.9
Asic4
acid-sensing (proton-gated) ion channel family member 4
chr1_+_75450436 1.324 ENSMUST00000113577.1
Asic4
acid-sensing (proton-gated) ion channel family member 4
chrX_-_142390334 1.264 ENSMUST00000112907.1
Acsl4
acyl-CoA synthetase long-chain family member 4
chr7_+_35397046 1.223 ENSMUST00000079414.5
Cep89
centrosomal protein 89
chr5_+_128601106 1.218 ENSMUST00000117102.2
Fzd10
frizzled homolog 10 (Drosophila)
chr17_-_25861456 1.189 ENSMUST00000079461.8
ENSMUST00000176923.1
Wdr90

WD repeat domain 90

chr1_+_12718496 1.189 ENSMUST00000088585.3
Sulf1
sulfatase 1
chr4_-_41517326 1.141 ENSMUST00000030152.6
ENSMUST00000095126.4
1110017D15Rik

RIKEN cDNA 1110017D15 gene

chr12_-_30911593 1.141 ENSMUST00000062740.7
ENSMUST00000074038.5
Acp1

acid phosphatase 1, soluble

chr17_-_34627365 1.128 ENSMUST00000064953.8
ENSMUST00000170345.1
ENSMUST00000171121.2
ENSMUST00000168391.2
ENSMUST00000169067.2
Ppt2




palmitoyl-protein thioesterase 2




chr16_-_76403673 1.126 ENSMUST00000052867.7
Gm9843
predicted gene 9843
chr1_+_135232045 1.125 ENSMUST00000110798.3
Gm4204
predicted gene 4204
chr9_+_75775355 1.117 ENSMUST00000012281.7
Bmp5
bone morphogenetic protein 5
chr2_-_170406501 1.057 ENSMUST00000154650.1
Bcas1
breast carcinoma amplified sequence 1
chr5_-_110779937 1.041 ENSMUST00000112426.1
Pus1
pseudouridine synthase 1
chr4_-_109665249 0.942 ENSMUST00000063531.4
Cdkn2c
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chrX_+_58030999 0.933 ENSMUST00000088631.4
ENSMUST00000088629.3
Zic3

zinc finger protein of the cerebellum 3

chr3_-_150073620 0.933 ENSMUST00000057740.5
Rpsa-ps10
ribosomal protein SA, pseudogene 10
chr17_-_25570678 0.933 ENSMUST00000025003.3
ENSMUST00000173447.1
Sox8

SRY-box containing gene 8

chr5_+_30105161 0.932 ENSMUST00000058045.4
Gareml
GRB2 associated, regulator of MAPK1-like
chr3_-_95411176 0.914 ENSMUST00000177599.1
Gm5070
predicted gene 5070
chr17_-_34628005 0.896 ENSMUST00000166040.2
Ppt2
palmitoyl-protein thioesterase 2
chr15_+_99702278 0.893 ENSMUST00000023759.4
Smarcd1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
chr17_-_34628380 0.809 ENSMUST00000167097.2
Ppt2
palmitoyl-protein thioesterase 2
chr2_-_158146385 0.787 ENSMUST00000103122.3
Tgm2
transglutaminase 2, C polypeptide
chr8_+_23411490 0.786 ENSMUST00000033952.7
Sfrp1
secreted frizzled-related protein 1
chr10_+_14523062 0.777 ENSMUST00000096020.5
Gm10335
predicted gene 10335
chrX_+_58030622 0.759 ENSMUST00000088627.4
Zic3
zinc finger protein of the cerebellum 3
chr17_-_32388885 0.699 ENSMUST00000087703.5
ENSMUST00000170603.1
Wiz

widely-interspaced zinc finger motifs

chr4_+_45203921 0.666 ENSMUST00000107804.1
Frmpd1
FERM and PDZ domain containing 1
chr14_+_7817957 0.649 ENSMUST00000052678.8
Flnb
filamin, beta
chr13_-_71963713 0.642 ENSMUST00000077337.8
Irx1
Iroquois related homeobox 1 (Drosophila)
chr17_+_34263209 0.488 ENSMUST00000040828.5
H2-Ab1
histocompatibility 2, class II antigen A, beta 1
chr11_+_100622971 0.482 ENSMUST00000142993.1
Nkiras2
NFKB inhibitor interacting Ras-like protein 2
chr17_-_36951636 0.473 ENSMUST00000040402.7
ENSMUST00000174711.1
Ppp1r11

protein phosphatase 1, regulatory (inhibitor) subunit 11

chr1_-_162898665 0.462 ENSMUST00000111510.1
ENSMUST00000045902.6
Fmo2

flavin containing monooxygenase 2

chr2_-_121235689 0.456 ENSMUST00000142400.1
Trp53bp1
transformation related protein 53 binding protein 1
chrX_-_111463043 0.438 ENSMUST00000065976.5
Rps6ka6
ribosomal protein S6 kinase polypeptide 6
chr12_-_71136611 0.409 ENSMUST00000021486.8
ENSMUST00000166120.1
Timm9

translocase of inner mitochondrial membrane 9

chr4_+_120854786 0.403 ENSMUST00000071093.2
Rims3
regulating synaptic membrane exocytosis 3
chr12_+_78748947 0.396 ENSMUST00000082024.5
Mpp5
membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
chr7_+_51879041 0.389 ENSMUST00000107591.2
Gas2
growth arrest specific 2
chr9_+_119937606 0.388 ENSMUST00000035100.5
Ttc21a
tetratricopeptide repeat domain 21A
chr13_+_23738804 0.385 ENSMUST00000040914.1
Hist1h1c
histone cluster 1, H1c
chr14_+_27238018 0.364 ENSMUST00000049206.5
Arhgef3
Rho guanine nucleotide exchange factor (GEF) 3
chr15_+_80234071 0.349 ENSMUST00000023048.4
ENSMUST00000166030.1
Mief1

mitochondrial elongation factor 1

chr16_+_44139821 0.339 ENSMUST00000159514.1
ENSMUST00000161326.1
ENSMUST00000063520.8
ENSMUST00000063542.7
Naa50



N(alpha)-acetyltransferase 50, NatE catalytic subunit



chr7_+_51878967 0.318 ENSMUST00000051912.6
Gas2
growth arrest specific 2
chr3_-_37125943 0.318 ENSMUST00000029275.5
Il2
interleukin 2
chr2_+_71786923 0.312 ENSMUST00000112101.1
ENSMUST00000028522.3
Itga6

integrin alpha 6

chr11_+_80428598 0.312 ENSMUST00000173938.1
ENSMUST00000017572.7
Psmd11

proteasome (prosome, macropain) 26S subunit, non-ATPase, 11

chr11_+_70432627 0.218 ENSMUST00000084954.6
ENSMUST00000108568.3
ENSMUST00000079056.2
ENSMUST00000102564.4
ENSMUST00000124943.1
ENSMUST00000150076.1
ENSMUST00000102563.1
Arrb2






arrestin, beta 2






chr15_+_76710610 0.210 ENSMUST00000136840.1
ENSMUST00000127208.1
ENSMUST00000036423.8
ENSMUST00000137649.1
ENSMUST00000155225.1
ENSMUST00000155735.1
Lrrc14





leucine rich repeat containing 14





chr2_+_80638798 0.203 ENSMUST00000028382.6
ENSMUST00000124377.1
Nup35

nucleoporin 35

chr8_-_83442648 0.194 ENSMUST00000167525.1
Scoc
short coiled-coil protein
chr19_-_8839181 0.192 ENSMUST00000096259.4
Gng3
guanine nucleotide binding protein (G protein), gamma 3
chr3_-_108200807 0.187 ENSMUST00000106655.1
ENSMUST00000065664.6
Cyb561d1

cytochrome b-561 domain containing 1

chr1_-_54194048 0.176 ENSMUST00000120904.1
Hecw2
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
chr17_-_36951338 0.156 ENSMUST00000173540.1
Ppp1r11
protein phosphatase 1, regulatory (inhibitor) subunit 11
chrX_+_114474312 0.147 ENSMUST00000113371.1
ENSMUST00000040504.5
Klhl4

kelch-like 4

chr15_-_10470490 0.120 ENSMUST00000136591.1
Dnajc21
DnaJ (Hsp40) homolog, subfamily C, member 21
chr18_-_36670269 0.112 ENSMUST00000006209.4
Sra1
steroid receptor RNA activator 1
chr11_-_86257518 0.109 ENSMUST00000136469.1
ENSMUST00000018212.6
Ints2

integrator complex subunit 2

chr11_-_120086790 0.089 ENSMUST00000106227.1
ENSMUST00000106229.1
ENSMUST00000180242.1
Azi1


5-azacytidine induced gene 1


chr7_-_28372233 0.087 ENSMUST00000094644.4
Plekhg2
pleckstrin homology domain containing, family G (with RhoGef domain) member 2
chr5_+_145083830 0.082 ENSMUST00000031625.8
Arpc1a
actin related protein 2/3 complex, subunit 1A
chrX_+_7762652 0.080 ENSMUST00000077680.3
ENSMUST00000079542.6
ENSMUST00000115679.1
ENSMUST00000137467.1
Tfe3



transcription factor E3



chr1_+_63176818 0.073 ENSMUST00000129339.1
Eef1b2
eukaryotic translation elongation factor 1 beta 2
chr7_+_30563838 0.066 ENSMUST00000163330.1
U2af1l4
U2 small nuclear RNA auxiliary factor 1-like 4
chr2_+_80315461 0.057 ENSMUST00000028392.7
Dnajc10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr13_+_55635002 0.023 ENSMUST00000172272.1
ENSMUST00000099479.3
Ddx46

DEAD (Asp-Glu-Ala-Asp) box polypeptide 46

chrX_-_111463103 0.014 ENSMUST00000137712.2
Rps6ka6
ribosomal protein S6 kinase polypeptide 6
chr4_-_98383232 0.011 ENSMUST00000143116.1
ENSMUST00000030292.5
ENSMUST00000102793.4
Tm2d1


TM2 domain containing 1


chr7_-_126200397 0.008 ENSMUST00000009344.9
Xpo6
exportin 6
chr11_+_95666957 0.001 ENSMUST00000125172.1
ENSMUST00000036374.5
Phb

prohibitin


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 6.3 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.8 2.4 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.7 1.4 GO:0009814 defense response, incompatible interaction(GO:0009814)
0.7 2.6 GO:0051866 general adaptation syndrome(GO:0051866)
0.6 1.9 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.6 5.7 GO:0060179 male mating behavior(GO:0060179)
0.5 2.3 GO:1903215 negative regulation of protein targeting to mitochondrion(GO:1903215)
0.4 3.9 GO:0047484 regulation of response to osmotic stress(GO:0047484) cellular response to cholesterol(GO:0071397)
0.3 2.0 GO:1904587 response to glycoprotein(GO:1904587)
0.3 5.2 GO:0097154 GABAergic neuron differentiation(GO:0097154)
0.3 0.9 GO:0072034 renal vesicle induction(GO:0072034)
0.3 1.2 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.3 1.7 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.3 1.1 GO:0021502 neural fold elevation formation(GO:0021502)
0.3 2.6 GO:0090527 actin filament reorganization(GO:0090527)
0.3 0.8 GO:0018199 peptidyl-glutamine modification(GO:0018199)
0.3 0.8 GO:1904956 Wnt signaling pathway involved in somitogenesis(GO:0090244) regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.2 1.0 GO:1990481 mRNA pseudouridine synthesis(GO:1990481)
0.2 3.6 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.2 0.6 GO:0072272 proximal/distal pattern formation involved in metanephric nephron development(GO:0072272)
0.2 1.2 GO:0038030 non-canonical Wnt signaling pathway via MAPK cascade(GO:0038030) non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.1 1.3 GO:0032306 regulation of prostaglandin secretion(GO:0032306)
0.1 1.3 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.1 0.5 GO:0072592 oxygen metabolic process(GO:0072592)
0.1 0.5 GO:0002339 B cell selection(GO:0002339)
0.1 0.4 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.1 0.3 GO:0046013 T cell homeostatic proliferation(GO:0001777) regulation of T cell homeostatic proliferation(GO:0046013) negative regulation of T-helper 17 type immune response(GO:2000317) regulation of T-helper 17 cell differentiation(GO:2000319) negative regulation of T-helper 17 cell differentiation(GO:2000320)
0.1 1.5 GO:0032060 bleb assembly(GO:0032060)
0.1 0.7 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.1 0.9 GO:0006337 nucleosome disassembly(GO:0006337)
0.1 0.4 GO:0016584 nucleosome positioning(GO:0016584)
0.1 0.2 GO:0034392 negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.1 0.3 GO:0035878 nail development(GO:0035878)
0.0 0.5 GO:2000381 negative regulation of mesoderm development(GO:2000381)
0.0 2.8 GO:2000179 positive regulation of neural precursor cell proliferation(GO:2000179)
0.0 0.3 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.0 0.6 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0 0.6 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.9 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.0 0.5 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0 0.4 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)
0.0 1.4 GO:0016126 sterol biosynthetic process(GO:0016126)
0.0 1.6 GO:0042632 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.0 0.4 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.0 0.3 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.2 GO:0061635 regulation of protein complex stability(GO:0061635)
0.0 0.3 GO:0090141 positive regulation of mitochondrial fission(GO:0090141)
0.0 0.4 GO:2000300 regulation of synaptic vesicle exocytosis(GO:2000300)
0.0 0.2 GO:0006999 nuclear pore organization(GO:0006999)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 6.3 GO:0032133 interphase microtubule organizing center(GO:0031021) chromosome passenger complex(GO:0032133)
0.3 1.9 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.2 3.5 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 1.1 GO:0002177 manchette(GO:0002177)
0.1 1.3 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.1 1.6 GO:0005652 nuclear lamina(GO:0005652)
0.1 0.4 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.1 1.2 GO:0097539 ciliary transition fiber(GO:0097539)
0.1 0.5 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.4 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.0 0.6 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.9 GO:0071564 npBAF complex(GO:0071564)
0.0 0.4 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 0.3 GO:0031415 NatA complex(GO:0031415)
0.0 3.9 GO:0005901 caveola(GO:0005901)
0.0 0.3 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.3 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.4 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 1.6 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 2.6 GO:0005884 actin filament(GO:0005884)
0.0 4.9 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.1 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0 0.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 2.8 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 0.1 GO:0089701 U2AF(GO:0089701)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.6 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.3 2.8 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.2 1.2 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.2 0.2 GO:0031762 alpha-1A adrenergic receptor binding(GO:0031691) alpha-1B adrenergic receptor binding(GO:0031692) follicle-stimulating hormone receptor binding(GO:0031762)
0.2 0.8 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.2 1.4 GO:0070087 chromo shadow domain binding(GO:0070087)
0.2 2.0 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.2 1.1 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.1 6.3 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 2.4 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 4.6 GO:0005109 frizzled binding(GO:0005109)
0.1 1.3 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 1.1 GO:0070700 BMP receptor binding(GO:0070700)
0.1 0.5 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 0.6 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.1 2.7 GO:0005272 sodium channel activity(GO:0005272)
0.1 2.6 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 1.2 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 0.9 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 0.3 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.1 0.3 GO:0038132 neuregulin binding(GO:0038132)
0.1 0.4 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.1 1.0 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.5 GO:1990405 protein antigen binding(GO:1990405)
0.0 1.1 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 3.9 GO:0008565 protein transporter activity(GO:0008565)
0.0 1.9 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.0 0.9 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 1.4 GO:0042054 histone methyltransferase activity(GO:0042054)
0.0 0.3 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 1.4 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 3.5 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.0 0.1 GO:0010861 thyroid hormone receptor activator activity(GO:0010861)
0.0 0.2 GO:0031702 angiotensin receptor binding(GO:0031701) type 1 angiotensin receptor binding(GO:0031702)
0.0 5.9 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 4.6 GO:0045296 cadherin binding(GO:0045296)
0.0 0.2 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 9.8 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 1.8 PID_ARF6_PATHWAY Arf6 signaling events
0.0 1.1 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 1.2 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.8 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.0 0.8 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 5.5 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 1.4 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 0.7 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 1.0 PID_E2F_PATHWAY E2F transcription factor network
0.0 0.9 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS Genes involved in Hormone ligand-binding receptors
0.1 1.4 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.1 5.3 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.4 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 6.3 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 1.3 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 2.6 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.7 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.4 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.9 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 2.4 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.0 0.2 REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0 0.5 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.3 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.9 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 0.4 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 0.5 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1