Motif ID: Smad2

Z-value: 0.475


Transcription factors associated with Smad2:

Gene SymbolEntrez IDGene Name
Smad2 ENSMUSG00000024563.9 Smad2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad2mm10_v2_chr18_+_76242135_76242174-0.729.7e-08Click!


Activity profile for motif Smad2.

activity profile for motif Smad2


Sorted Z-values histogram for motif Smad2

Sorted Z-values for motif Smad2



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_116237767 2.335 ENSMUST00000182834.1
Plekha7
pleckstrin homology domain containing, family A member 7
chr6_-_6882068 2.004 ENSMUST00000142635.1
ENSMUST00000052609.8
Dlx5

distal-less homeobox 5

chr10_-_42583628 1.891 ENSMUST00000019938.4
Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr8_-_87959560 1.829 ENSMUST00000109655.2
Zfp423
zinc finger protein 423
chr9_-_119578981 1.599 ENSMUST00000117911.1
ENSMUST00000120420.1
Scn5a

sodium channel, voltage-gated, type V, alpha

chr4_+_11191726 1.522 ENSMUST00000029866.9
ENSMUST00000108324.3
Ccne2

cyclin E2

chr14_-_12345847 1.388 ENSMUST00000022262.4
Fezf2
Fez family zinc finger 2
chr16_+_64851991 1.336 ENSMUST00000067744.7
Cggbp1
CGG triplet repeat binding protein 1
chr8_-_105637403 1.241 ENSMUST00000182046.1
Gm5914
predicted gene 5914
chr1_-_172297989 1.220 ENSMUST00000085913.4
ENSMUST00000097464.2
ENSMUST00000137679.1
Atp1a2


ATPase, Na+/K+ transporting, alpha 2 polypeptide


chr19_+_59458372 1.139 ENSMUST00000062216.3
Emx2
empty spiracles homeobox 2
chr10_-_37138863 1.041 ENSMUST00000092584.5
Marcks
myristoylated alanine rich protein kinase C substrate
chr13_+_23752267 1.031 ENSMUST00000091703.2
Hist1h3b
histone cluster 1, H3b
chr3_+_127633134 0.906 ENSMUST00000029587.7
Neurog2
neurogenin 2
chr4_+_117849193 0.891 ENSMUST00000132043.2
ENSMUST00000169990.1
Slc6a9

solute carrier family 6 (neurotransmitter transporter, glycine), member 9

chr8_-_105637350 0.867 ENSMUST00000182863.1
Gm5914
predicted gene 5914
chr4_+_117849361 0.858 ENSMUST00000163288.1
Slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr13_-_78199757 0.856 ENSMUST00000091458.6
Nr2f1
nuclear receptor subfamily 2, group F, member 1
chr15_-_103251465 0.806 ENSMUST00000133600.1
ENSMUST00000134554.1
ENSMUST00000156927.1
ENSMUST00000149111.1
ENSMUST00000132836.1
Nfe2




nuclear factor, erythroid derived 2




chr7_+_82867327 0.780 ENSMUST00000082237.5
Mex3b
mex3 homolog B (C. elegans)
chr4_+_11191354 0.773 ENSMUST00000170901.1
Ccne2
cyclin E2
chr6_+_83137089 0.760 ENSMUST00000121093.1
ENSMUST00000087938.4
Rtkn

rhotekin

chr17_-_34615965 0.740 ENSMUST00000097345.3
ENSMUST00000015611.7
Egfl8

EGF-like domain 8

chr11_+_63131512 0.653 ENSMUST00000018361.3
Pmp22
peripheral myelin protein 22
chr17_-_25861456 0.607 ENSMUST00000079461.8
ENSMUST00000176923.1
Wdr90

WD repeat domain 90

chr8_-_90908415 0.590 ENSMUST00000098517.1
Gm6658
predicted gene 6658
chr14_-_31168587 0.539 ENSMUST00000036618.7
Stab1
stabilin 1
chrX_-_20931520 0.515 ENSMUST00000001156.7
Cfp
complement factor properdin
chr6_-_55175019 0.506 ENSMUST00000003569.5
Inmt
indolethylamine N-methyltransferase
chr3_+_135438722 0.488 ENSMUST00000166033.1
Ube2d3
ubiquitin-conjugating enzyme E2D 3
chr2_-_128967725 0.484 ENSMUST00000099385.2
Gm10762
predicted gene 10762
chr7_-_45052865 0.481 ENSMUST00000057293.6
Prr12
proline rich 12
chr14_-_20496780 0.474 ENSMUST00000022353.3
Mss51
MSS51 mitochondrial translational activator
chr7_-_29180699 0.457 ENSMUST00000059642.10
Psmd8
proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
chr13_+_104817171 0.439 ENSMUST00000022230.8
Srek1ip1
splicing regulatory glutamine/lysine-rich protein 1interacting protein 1
chr7_-_29180454 0.412 ENSMUST00000182328.1
Psmd8
proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
chr10_-_49788743 0.408 ENSMUST00000105483.1
ENSMUST00000105487.1
Grik2

glutamate receptor, ionotropic, kainate 2 (beta 2)

chr9_+_44107286 0.392 ENSMUST00000152956.1
ENSMUST00000114815.1
C1qtnf5

C1q and tumor necrosis factor related protein 5

chr15_+_102102926 0.373 ENSMUST00000169627.1
ENSMUST00000046144.9
Tenc1

tensin like C1 domain-containing phosphatase

chrX_-_94123359 0.344 ENSMUST00000137853.1
ENSMUST00000088102.5
ENSMUST00000113927.1
Zfx


zinc finger protein X-linked


chr3_+_89136133 0.343 ENSMUST00000047111.6
Pklr
pyruvate kinase liver and red blood cell
chr17_+_7925990 0.342 ENSMUST00000036370.7
Tagap
T cell activation Rho GTPase activating protein
chr8_+_109705549 0.341 ENSMUST00000034163.8
Zfp821
zinc finger protein 821
chr13_-_104816908 0.339 ENSMUST00000022228.6
Cwc27
CWC27 spliceosome-associated protein homolog (S. cerevisiae)
chr17_-_35700520 0.335 ENSMUST00000119825.1
Ddr1
discoidin domain receptor family, member 1
chr7_+_101321703 0.323 ENSMUST00000174291.1
ENSMUST00000167888.2
ENSMUST00000172662.1
ENSMUST00000173270.1
ENSMUST00000174083.1
Stard10




START domain containing 10




chr7_-_34654342 0.282 ENSMUST00000108069.1
Kctd15
potassium channel tetramerisation domain containing 15
chr18_-_42579652 0.260 ENSMUST00000054738.3
Gpr151
G protein-coupled receptor 151
chr18_+_40258361 0.257 ENSMUST00000091927.4
Kctd16
potassium channel tetramerisation domain containing 16
chr11_+_101119938 0.256 ENSMUST00000043680.8
Tubg1
tubulin, gamma 1
chr10_+_80150448 0.248 ENSMUST00000153477.1
Midn
midnolin
chrX_+_99821021 0.238 ENSMUST00000096363.2
Tmem28
transmembrane protein 28
chr5_-_113800356 0.231 ENSMUST00000160374.1
ENSMUST00000067853.5
Tmem119

transmembrane protein 119

chr12_+_33147693 0.221 ENSMUST00000077456.6
ENSMUST00000110824.2
Atxn7l1

ataxin 7-like 1

chr14_-_18331855 0.214 ENSMUST00000022296.6
Ube2e1
ubiquitin-conjugating enzyme E2E 1
chr2_+_156863110 0.195 ENSMUST00000029165.3
1110008F13Rik
RIKEN cDNA 1110008F13 gene
chrX_-_7947848 0.175 ENSMUST00000115642.1
ENSMUST00000033501.8
ENSMUST00000145675.1
Hdac6


histone deacetylase 6


chr2_-_148443543 0.133 ENSMUST00000099269.3
Cd93
CD93 antigen
chr11_-_75190458 0.130 ENSMUST00000044949.4
Dph1
DPH1 homolog (S. cerevisiae)
chr2_-_91950386 0.084 ENSMUST00000111303.1
Dgkz
diacylglycerol kinase zeta
chr3_+_135438280 0.082 ENSMUST00000106291.3
Ube2d3
ubiquitin-conjugating enzyme E2D 3
chr17_-_35980197 0.073 ENSMUST00000055454.7
Prr3
proline-rich polypeptide 3
chr2_+_177768044 0.072 ENSMUST00000108942.3
Gm14322
predicted gene 14322
chr6_+_125009665 0.056 ENSMUST00000046064.10
ENSMUST00000152752.1
ENSMUST00000088308.3
ENSMUST00000112425.1
ENSMUST00000084275.5
Zfp384




zinc finger protein 384




chr14_+_21500879 0.042 ENSMUST00000182964.1
Kat6b
K(lysine) acetyltransferase 6B
chr17_-_46032366 0.025 ENSMUST00000071648.5
ENSMUST00000142351.2
ENSMUST00000167860.1
Vegfa


vascular endothelial growth factor A


chr6_-_142702259 0.024 ENSMUST00000073173.5
ENSMUST00000111771.1
ENSMUST00000087527.4
ENSMUST00000100827.2
Abcc9



ATP-binding cassette, sub-family C (CFTR/MRP), member 9



chr3_+_58576636 0.002 ENSMUST00000107924.1
Selt
selenoprotein T

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0060166 olfactory pit development(GO:0060166)
0.6 1.7 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.5 1.6 GO:0014877 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) membrane depolarization during Purkinje myocyte cell action potential(GO:0086047)
0.4 1.2 GO:1903279 regulation of calcium:sodium antiporter activity(GO:1903279)
0.4 2.3 GO:0045218 zonula adherens maintenance(GO:0045218)
0.4 1.9 GO:0021764 amygdala development(GO:0021764)
0.2 1.4 GO:1904936 forebrain anterior/posterior pattern specification(GO:0021797) cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.1 2.0 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.1 0.8 GO:0072697 protein localization to cell cortex(GO:0072697)
0.1 0.5 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 0.8 GO:0034242 negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
0.1 2.3 GO:0007129 synapsis(GO:0007129)
0.1 0.9 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.2 GO:1903012 positive regulation of bone development(GO:1903012)
0.0 0.3 GO:0032782 bile acid secretion(GO:0032782) positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.0 0.3 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.0 1.8 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 1.0 GO:0051764 actin crosslink formation(GO:0051764)
0.0 0.4 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 0.2 GO:0098703 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.0 1.0 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.7 GO:0032060 bleb assembly(GO:0032060)
0.0 0.1 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 0.2 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.0 0.3 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.2 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.6 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.3 GO:0000212 meiotic spindle organization(GO:0000212)
0.0 0.0 GO:0003169 coronary vein morphogenesis(GO:0003169)
0.0 0.3 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.3 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.3 1.0 GO:0042585 germinal vesicle(GO:0042585)
0.2 2.3 GO:0005915 zonula adherens(GO:0005915)
0.2 1.2 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.1 1.6 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 0.9 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1 0.4 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 0.3 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.3 GO:0005827 polar microtubule(GO:0005827)
0.0 1.0 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.7 GO:0043218 compact myelin(GO:0043218)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.6 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.2 2.3 GO:0070097 delta-catenin binding(GO:0070097)
0.2 1.7 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.1 1.2 GO:1990239 steroid hormone binding(GO:1990239)
0.1 0.5 GO:0008172 S-methyltransferase activity(GO:0008172)
0.1 0.8 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.1 0.3 GO:0004743 pyruvate kinase activity(GO:0004743)
0.1 0.2 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.1 0.4 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 2.3 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 2.0 GO:0071837 HMG box domain binding(GO:0071837)
0.1 0.9 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 0.5 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.3 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 0.2 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.8 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 1.9 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 0.8 GO:0050699 WW domain binding(GO:0050699)
0.0 0.9 GO:0070888 E-box binding(GO:0070888)
0.0 1.0 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.1 GO:0001849 complement component C1q binding(GO:0001849)
0.0 1.0 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 2.7 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.3 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 2.0 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 2.3 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.6 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 0.7 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.7 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 1.0 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 2.3 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.0 1.6 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 2.7 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.2 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.3 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.6 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.4 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 1.0 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.9 REACTOME_CDK_MEDIATED_PHOSPHORYLATION_AND_REMOVAL_OF_CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.0 0.2 REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC_C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.0 0.3 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells