Motif ID: Nkx1-1_Nkx1-2

Z-value: 0.588

Transcription factors associated with Nkx1-1_Nkx1-2:

Gene SymbolEntrez IDGene Name
Nkx1-1 ENSMUSG00000029112.5 Nkx1-1
Nkx1-2 ENSMUSG00000048528.7 Nkx1-2






Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx1-1_Nkx1-2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_55782500 9.710 ENSMUST00000075422.4
Mab21l1
mab-21-like 1 (C. elegans)
chrX_-_60893430 8.140 ENSMUST00000135107.2
Sox3
SRY-box containing gene 3
chr6_-_23248264 5.243 ENSMUST00000031709.5
Fezf1
Fez family zinc finger 1
chr5_+_140607334 4.505 ENSMUST00000031555.1
Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr14_+_46760526 2.219 ENSMUST00000067426.4
Cdkn3
cyclin-dependent kinase inhibitor 3
chr13_-_102906046 2.201 ENSMUST00000171791.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr6_-_124779686 2.183 ENSMUST00000147669.1
ENSMUST00000128697.1
ENSMUST00000032218.3
ENSMUST00000112475.2
Lrrc23



leucine rich repeat containing 23



chr5_+_9100681 2.064 ENSMUST00000115365.1
Tmem243
transmembrane protein 243, mitochondrial
chr13_-_102905740 2.026 ENSMUST00000167462.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr7_-_143460989 1.997 ENSMUST00000167912.1
ENSMUST00000037287.6
Cdkn1c

cyclin-dependent kinase inhibitor 1C (P57)

chr11_-_87108656 1.820 ENSMUST00000051395.8
Prr11
proline rich 11
chr12_-_40037387 1.678 ENSMUST00000146905.1
Arl4a
ADP-ribosylation factor-like 4A
chr14_-_8666236 1.621 ENSMUST00000102996.3
4930452B06Rik
RIKEN cDNA 4930452B06 gene
chr19_+_5490475 1.217 ENSMUST00000116560.2
Cfl1
cofilin 1, non-muscle
chr16_+_52031549 1.207 ENSMUST00000114471.1
Cblb
Casitas B-lineage lymphoma b
chr3_+_94372794 1.196 ENSMUST00000029795.3
Rorc
RAR-related orphan receptor gamma
chr4_-_141599835 1.168 ENSMUST00000141518.1
ENSMUST00000127455.1
ENSMUST00000105784.1
ENSMUST00000147785.1
Fblim1



filamin binding LIM protein 1



chrX_+_106015699 1.132 ENSMUST00000033582.4
Cox7b
cytochrome c oxidase subunit VIIb
chr10_-_88146867 1.064 ENSMUST00000164121.1
ENSMUST00000164803.1
ENSMUST00000168163.1
ENSMUST00000048518.9
Parpbp



PARP1 binding protein



chr18_+_4993795 1.033 ENSMUST00000153016.1
Svil
supervillin
chr9_+_66126611 0.955 ENSMUST00000034945.5
Fam96a
family with sequence similarity 96, member A
chr4_-_119294520 0.902 ENSMUST00000079644.6
Ybx1
Y box protein 1
chr14_-_52104015 0.881 ENSMUST00000111610.4
ENSMUST00000164655.1
Hnrnpc

heterogeneous nuclear ribonucleoprotein C

chr11_+_43681998 0.867 ENSMUST00000061070.5
Pwwp2a
PWWP domain containing 2A
chr5_+_138187485 0.803 ENSMUST00000110934.2
Cnpy4
canopy 4 homolog (zebrafish)
chr9_-_100486788 0.790 ENSMUST00000098458.3
Il20rb
interleukin 20 receptor beta
chr10_+_88147061 0.787 ENSMUST00000169309.1
Nup37
nucleoporin 37
chr11_+_43682038 0.767 ENSMUST00000094294.4
Pwwp2a
PWWP domain containing 2A
chr10_+_88146992 0.761 ENSMUST00000052355.7
Nup37
nucleoporin 37
chr4_-_140774196 0.756 ENSMUST00000026381.6
Padi4
peptidyl arginine deiminase, type IV
chr10_+_128337761 0.709 ENSMUST00000005826.7
Cs
citrate synthase
chr11_-_21371143 0.696 ENSMUST00000060895.5
Ugp2
UDP-glucose pyrophosphorylase 2
chr7_+_101896340 0.691 ENSMUST00000035395.7
ENSMUST00000106973.1
ENSMUST00000144207.1
Anapc15


anaphase prompoting complex C subunit 15


chr11_+_87109221 0.682 ENSMUST00000020794.5
Ska2
spindle and kinetochore associated complex subunit 2
chr17_-_48432723 0.646 ENSMUST00000046549.3
Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr4_-_14621669 0.641 ENSMUST00000143105.1
Slc26a7
solute carrier family 26, member 7
chr2_+_119047116 0.623 ENSMUST00000152380.1
ENSMUST00000099542.2
Casc5

cancer susceptibility candidate 5

chr7_-_27195727 0.606 ENSMUST00000163311.2
ENSMUST00000126211.1
Snrpa

small nuclear ribonucleoprotein polypeptide A

chr7_+_128744870 0.574 ENSMUST00000042942.8
Sec23ip
Sec23 interacting protein
chr12_+_84417196 0.504 ENSMUST00000183146.1
Rnf113a2
ring finger protein 113A2
chr3_-_89101907 0.500 ENSMUST00000081848.8
Fdps
farnesyl diphosphate synthetase
chr10_+_94575257 0.475 ENSMUST00000121471.1
Tmcc3
transmembrane and coiled coil domains 3
chr14_-_59365410 0.473 ENSMUST00000161031.1
ENSMUST00000160425.1
Phf11d

PHD finger protein 11D

chr3_-_116424007 0.449 ENSMUST00000090464.4
Cdc14a
CDC14 cell division cycle 14A
chr8_+_33599608 0.431 ENSMUST00000009774.9
Ppp2cb
protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
chr3_-_116423930 0.425 ENSMUST00000106491.2
Cdc14a
CDC14 cell division cycle 14A
chr2_+_119047129 0.420 ENSMUST00000153300.1
ENSMUST00000028799.5
Casc5

cancer susceptibility candidate 5

chr15_+_81663889 0.403 ENSMUST00000023029.8
ENSMUST00000174229.1
ENSMUST00000172748.1
L3mbtl2


l(3)mbt-like 2 (Drosophila)


chr11_-_43747963 0.389 ENSMUST00000048578.2
ENSMUST00000109278.1
Ttc1

tetratricopeptide repeat domain 1

chr9_-_20959785 0.384 ENSMUST00000177754.1
Dnmt1
DNA methyltransferase (cytosine-5) 1
chr11_-_99230998 0.376 ENSMUST00000103133.3
Smarce1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
chr17_-_63863791 0.376 ENSMUST00000050753.3
A930002H24Rik
RIKEN cDNA A930002H24 gene
chr9_-_44113470 0.372 ENSMUST00000056328.5
Rnf26
ring finger protein 26
chr7_+_101896817 0.366 ENSMUST00000143835.1
Anapc15
anaphase prompoting complex C subunit 15
chr14_-_5863663 0.337 ENSMUST00000178594.1
Gm8237
predicted gene 8237
chrY_+_90785442 0.334 ENSMUST00000177591.1
ENSMUST00000177671.1
ENSMUST00000179077.1
Erdr1


erythroid differentiation regulator 1


chr2_-_69712461 0.329 ENSMUST00000102706.3
ENSMUST00000073152.6
Fastkd1

FAST kinase domains 1

chr4_-_14621494 0.302 ENSMUST00000149633.1
Slc26a7
solute carrier family 26, member 7
chr1_-_172027269 0.295 ENSMUST00000027837.6
ENSMUST00000111264.1
Vangl2

vang-like 2 (van gogh, Drosophila)

chr4_-_14621805 0.229 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chrX_+_170009892 0.223 ENSMUST00000180251.1
Gm21887
predicted gene, 21887
chr14_+_4198185 0.182 ENSMUST00000180184.1
Gm2974
predicted gene 2974
chr3_-_34351685 0.182 ENSMUST00000174114.1
Gm20514
predicted gene 20514
chr7_+_29983948 0.176 ENSMUST00000148442.1
Zfp568
zinc finger protein 568
chr4_-_132075250 0.171 ENSMUST00000105970.1
ENSMUST00000105975.1
Epb4.1

erythrocyte protein band 4.1

chr7_-_30552255 0.170 ENSMUST00000108165.1
ENSMUST00000153594.1
BC053749

cDNA sequence BC053749

chr14_-_6266620 0.167 ENSMUST00000096172.5
Gm3411
predicted gene 3411
chrX_-_160138375 0.160 ENSMUST00000033662.8
Pdha1
pyruvate dehydrogenase E1 alpha 1
chr2_+_151494182 0.159 ENSMUST00000089140.6
Nsfl1c
NSFL1 (p97) cofactor (p47)
chr2_-_132247747 0.150 ENSMUST00000110163.1
ENSMUST00000180286.1
ENSMUST00000028816.2
Tmem230


transmembrane protein 230


chr3_-_90389884 0.139 ENSMUST00000029541.5
Slc27a3
solute carrier family 27 (fatty acid transporter), member 3
chr5_+_138116903 0.127 ENSMUST00000062350.8
ENSMUST00000110961.2
ENSMUST00000080732.3
ENSMUST00000110960.2
ENSMUST00000142185.1
ENSMUST00000136425.1
ENSMUST00000110959.1
Zscan21






zinc finger and SCAN domain containing 21






chrY_+_90784738 0.124 ENSMUST00000179483.1
Erdr1
erythroid differentiation regulator 1
chr5_-_137072254 0.113 ENSMUST00000077523.3
ENSMUST00000041388.4
Serpine1

serine (or cysteine) peptidase inhibitor, clade E, member 1

chr15_+_75993756 0.102 ENSMUST00000089669.4
Mapk15
mitogen-activated protein kinase 15
chrM_+_8600 0.090 ENSMUST00000082409.1
mt-Co3
mitochondrially encoded cytochrome c oxidase III
chr2_-_37703845 0.090 ENSMUST00000155237.1
Strbp
spermatid perinuclear RNA binding protein
chrX_+_107255878 0.089 ENSMUST00000101294.2
ENSMUST00000118820.1
ENSMUST00000120971.1
Gpr174


G protein-coupled receptor 174


chr9_-_107872403 0.084 ENSMUST00000183035.1
Rbm6
RNA binding motif protein 6
chr1_+_174501796 0.083 ENSMUST00000030039.7
Fmn2
formin 2
chr6_+_68161415 0.072 ENSMUST00000168090.1
Igkv1-115
immunoglobulin kappa variable 1-115
chr5_+_115605642 0.059 ENSMUST00000094427.3
Gcn1l1
GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
chr9_-_54661870 0.059 ENSMUST00000034822.5
Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr5_-_34660068 0.053 ENSMUST00000041364.9
Nop14
NOP14 nucleolar protein
chr2_-_165388245 0.038 ENSMUST00000103084.3
Zfp334
zinc finger protein 334
chr7_+_51880312 0.032 ENSMUST00000145049.1
Gas2
growth arrest specific 2
chr8_+_83972951 0.019 ENSMUST00000005606.6
Prkaca
protein kinase, cAMP dependent, catalytic, alpha
chr7_-_100964371 0.004 ENSMUST00000060174.4
P2ry6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr7_-_38019505 0.002 ENSMUST00000085513.4
Uri1
URI1, prefoldin-like chaperone
chr6_+_29694204 0.000 ENSMUST00000046750.7
ENSMUST00000115250.3
Tspan33

tetraspanin 33


Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 4.5 GO:0007386 compartment pattern specification(GO:0007386)
0.9 5.2 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.6 0.6 GO:0016554 cytidine to uridine editing(GO:0016554)
0.4 1.2 GO:2000812 unidimensional cell growth(GO:0009826) establishment or maintenance of cell polarity regulating cell shape(GO:0071963) regulation of barbed-end actin filament capping(GO:2000812)
0.4 1.2 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.4 8.1 GO:0007530 sex determination(GO:0007530)
0.3 0.8 GO:0002865 immune response-inhibiting signal transduction(GO:0002765) negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865)
0.2 0.7 GO:0006011 UDP-glucose metabolic process(GO:0006011) glucose 1-phosphate metabolic process(GO:0019255)
0.2 0.9 GO:0090365 regulation of mRNA modification(GO:0090365)
0.2 0.9 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.2 1.2 GO:0019532 oxalate transport(GO:0019532)
0.2 2.9 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.1 1.2 GO:0072615 interleukin-17 secretion(GO:0072615)
0.1 0.3 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.1 0.4 GO:0090309 positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.1 0.8 GO:0019240 citrulline biosynthetic process(GO:0019240)
0.1 1.2 GO:0033623 regulation of integrin activation(GO:0033623)
0.1 1.1 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.1 1.1 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.1 0.5 GO:0016114 terpenoid biosynthetic process(GO:0016114)
0.1 0.2 GO:0014022 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.1 0.5 GO:0043144 snoRNA processing(GO:0043144)
0.0 0.7 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.0 0.6 GO:0001675 acrosome assembly(GO:0001675)
0.0 1.7 GO:0050873 brown fat cell differentiation(GO:0050873)
0.0 0.1 GO:2000097 arachidonic acid metabolite production involved in inflammatory response(GO:0002538) regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.0 0.4 GO:0006337 nucleosome disassembly(GO:0006337)
0.0 0.1 GO:0070649 meiotic chromosome movement towards spindle pole(GO:0016344) formin-nucleated actin cable assembly(GO:0070649)
0.0 0.4 GO:0007398 ectoderm development(GO:0007398)
0.0 8.7 GO:0043010 camera-type eye development(GO:0043010)
0.0 0.2 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0 0.4 GO:0050687 negative regulation of defense response to virus(GO:0050687)
0.0 0.0 GO:0071374 cellular response to parathyroid hormone stimulus(GO:0071374)
0.0 0.2 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.0 0.4 GO:0046677 response to antibiotic(GO:0046677)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.1 1.5 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 4.5 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 1.1 GO:0045277 respiratory chain complex IV(GO:0045277)
0.1 0.3 GO:0060187 cell pole(GO:0060187)
0.1 0.7 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 0.2 GO:1990730 VCP-NSFL1C complex(GO:1990730)
0.0 1.1 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.9 GO:0045120 pronucleus(GO:0045120)
0.0 0.6 GO:0005685 U1 snRNP(GO:0005685)
0.0 0.2 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.1 GO:0042583 chromaffin granule(GO:0042583)
0.0 1.0 GO:0043034 costamere(GO:0043034)
0.0 0.5 GO:0005684 U2-type spliceosomal complex(GO:0005684)
0.0 0.6 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.4 GO:0071564 npBAF complex(GO:0071564)
0.0 0.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.4 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 1.2 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 1.2 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.1 GO:0030689 Noc complex(GO:0030689)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.5 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.3 1.2 GO:0008142 oxysterol binding(GO:0008142)
0.2 8.1 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.2 0.8 GO:0034618 arginine binding(GO:0034618)
0.2 0.6 GO:0004126 cytidine deaminase activity(GO:0004126)
0.1 2.0 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 0.8 GO:0004920 interleukin-10 receptor activity(GO:0004920)
0.1 0.6 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.1 0.7 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 1.2 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.1 0.9 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.1 1.2 GO:0031005 filamin binding(GO:0031005)
0.1 0.5 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.1 10.4 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.1 3.1 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 1.2 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.4 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.1 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.0 0.2 GO:0034604 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.0 1.2 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 3.1 GO:0000287 magnesium ion binding(GO:0000287)
0.0 0.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 2.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 1.2 GO:1902936 phosphatidylinositol bisphosphate binding(GO:1902936)
0.0 0.4 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.8 GO:0002039 p53 binding(GO:0002039)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 1.2 PID_CD40_PATHWAY CD40/CD40L signaling
0.0 0.4 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.9 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B
0.0 1.0 PID_AR_PATHWAY Coregulation of Androgen receptor activity

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.5 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 0.7 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.1 1.2 REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.0 1.5 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.9 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 1.2 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.4 REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0 1.2 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.7 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.5 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.0 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 1.2 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.1 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 2.4 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.0 0.2 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex