Motif ID: Hes5_Hes7
Z-value: 1.433


Transcription factors associated with Hes5_Hes7:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Hes5 | ENSMUSG00000048001.7 | Hes5 |
Hes7 | ENSMUSG00000023781.2 | Hes7 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Hes5 | mm10_v2_chr4_+_154960915_154960930 | 0.64 | 5.4e-06 | Click! |
Hes7 | mm10_v2_chr11_+_69120404_69120404 | -0.08 | 6.4e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
10.1 | 90.5 | GO:0070874 | negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874) |
5.1 | 15.2 | GO:0021529 | spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) musculoskeletal movement, spinal reflex action(GO:0050883) olfactory pit development(GO:0060166) |
2.2 | 6.5 | GO:0021759 | globus pallidus development(GO:0021759) |
1.9 | 5.8 | GO:0010814 | substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959) |
1.0 | 6.8 | GO:0006685 | sphingomyelin catabolic process(GO:0006685) |
0.9 | 7.4 | GO:0043951 | negative regulation of cAMP-mediated signaling(GO:0043951) |
0.9 | 2.7 | GO:0060167 | regulation of adenosine receptor signaling pathway(GO:0060167) regulation of G-protein coupled receptor internalization(GO:1904020) |
0.9 | 8.7 | GO:0042095 | interferon-gamma biosynthetic process(GO:0042095) |
0.6 | 1.7 | GO:0015772 | disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772) |
0.5 | 4.3 | GO:0006975 | DNA damage induced protein phosphorylation(GO:0006975) |
0.4 | 2.0 | GO:0010636 | positive regulation of mitochondrial fusion(GO:0010636) |
0.4 | 1.5 | GO:0015744 | succinate transport(GO:0015744) |
0.4 | 1.1 | GO:0009174 | UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049) |
0.2 | 4.7 | GO:0043567 | regulation of insulin-like growth factor receptor signaling pathway(GO:0043567) |
0.2 | 5.5 | GO:0045780 | positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852) |
0.2 | 0.7 | GO:0006344 | maintenance of chromatin silencing(GO:0006344) |
0.2 | 5.2 | GO:0008340 | determination of adult lifespan(GO:0008340) |
0.2 | 1.5 | GO:0038031 | non-canonical Wnt signaling pathway via JNK cascade(GO:0038031) |
0.2 | 1.8 | GO:0000244 | spliceosomal tri-snRNP complex assembly(GO:0000244) |
0.1 | 0.4 | GO:1903334 | positive regulation of protein folding(GO:1903334) |
0.1 | 1.1 | GO:0007016 | cytoskeletal anchoring at plasma membrane(GO:0007016) |
0.1 | 1.1 | GO:0033690 | positive regulation of osteoblast proliferation(GO:0033690) |
0.1 | 19.4 | GO:0030326 | embryonic limb morphogenesis(GO:0030326) embryonic appendage morphogenesis(GO:0035113) |
0.1 | 3.5 | GO:0030513 | positive regulation of BMP signaling pathway(GO:0030513) |
0.1 | 1.3 | GO:0090557 | establishment of endothelial intestinal barrier(GO:0090557) |
0.1 | 5.8 | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) |
0.1 | 12.6 | GO:0030177 | positive regulation of Wnt signaling pathway(GO:0030177) |
0.1 | 0.4 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
0.1 | 0.6 | GO:0061484 | hematopoietic stem cell homeostasis(GO:0061484) |
0.1 | 0.6 | GO:0007000 | nucleolus organization(GO:0007000) |
0.1 | 0.5 | GO:0019388 | galactose catabolic process(GO:0019388) |
0.1 | 1.8 | GO:0050850 | positive regulation of calcium-mediated signaling(GO:0050850) |
0.0 | 0.3 | GO:0009098 | branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099) |
0.0 | 2.1 | GO:0014003 | oligodendrocyte development(GO:0014003) |
0.0 | 0.7 | GO:0043248 | proteasome assembly(GO:0043248) |
0.0 | 0.7 | GO:0007250 | activation of NF-kappaB-inducing kinase activity(GO:0007250) |
0.0 | 0.2 | GO:0048170 | positive regulation of long-term neuronal synaptic plasticity(GO:0048170) |
0.0 | 0.4 | GO:0034143 | regulation of toll-like receptor 4 signaling pathway(GO:0034143) |
0.0 | 1.7 | GO:0048488 | synaptic vesicle endocytosis(GO:0048488) |
0.0 | 0.3 | GO:0006450 | regulation of translational fidelity(GO:0006450) |
0.0 | 0.1 | GO:0070944 | neutrophil mediated killing of bacterium(GO:0070944) |
0.0 | 0.2 | GO:0090286 | cytoskeletal anchoring at nuclear membrane(GO:0090286) |
0.0 | 0.2 | GO:0015991 | energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) |
0.0 | 4.4 | GO:1901657 | glycosyl compound metabolic process(GO:1901657) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.2 | 5.8 | GO:0033093 | Weibel-Palade body(GO:0033093) |
0.3 | 0.9 | GO:0097135 | cyclin E2-CDK2 complex(GO:0097135) |
0.2 | 1.7 | GO:0044233 | ER-mitochondrion membrane contact site(GO:0044233) |
0.2 | 1.3 | GO:0046581 | intercellular canaliculus(GO:0046581) |
0.1 | 1.7 | GO:0005652 | nuclear lamina(GO:0005652) |
0.1 | 15.2 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
0.1 | 1.8 | GO:0046540 | U4/U6 x U5 tri-snRNP complex(GO:0046540) |
0.1 | 0.6 | GO:0070545 | PeBoW complex(GO:0070545) |
0.1 | 6.8 | GO:0031225 | anchored component of membrane(GO:0031225) |
0.1 | 4.1 | GO:0005657 | replication fork(GO:0005657) |
0.0 | 0.4 | GO:0090543 | Flemming body(GO:0090543) |
0.0 | 4.0 | GO:0000118 | histone deacetylase complex(GO:0000118) |
0.0 | 0.7 | GO:0071564 | npBAF complex(GO:0071564) |
0.0 | 0.4 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
0.0 | 0.4 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
0.0 | 4.8 | GO:0005903 | brush border(GO:0005903) |
0.0 | 9.7 | GO:0016607 | nuclear speck(GO:0016607) |
0.0 | 5.5 | GO:0009897 | external side of plasma membrane(GO:0009897) |
0.0 | 6.1 | GO:0005667 | transcription factor complex(GO:0005667) |
0.0 | 0.2 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
0.0 | 65.5 | GO:0005829 | cytosol(GO:0005829) |
0.0 | 1.1 | GO:0005581 | collagen trimer(GO:0005581) |
0.0 | 1.9 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
0.0 | 1.1 | GO:0001726 | ruffle(GO:0001726) |
0.0 | 0.6 | GO:0031519 | PcG protein complex(GO:0031519) |
0.0 | 0.0 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
0.0 | 2.4 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.3 | 90.5 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
1.4 | 4.3 | GO:0035402 | histone kinase activity (H3-T11 specific)(GO:0035402) |
1.2 | 4.8 | GO:0008422 | beta-glucosidase activity(GO:0008422) |
0.9 | 6.8 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
0.7 | 2.7 | GO:0031687 | A2A adenosine receptor binding(GO:0031687) |
0.6 | 4.7 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
0.6 | 1.7 | GO:0008515 | sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157) |
0.5 | 6.5 | GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) |
0.5 | 1.5 | GO:0015140 | malate transmembrane transporter activity(GO:0015140) |
0.3 | 15.2 | GO:0070888 | E-box binding(GO:0070888) |
0.2 | 7.4 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
0.1 | 1.3 | GO:0071253 | connexin binding(GO:0071253) |
0.1 | 1.1 | GO:0030274 | LIM domain binding(GO:0030274) |
0.1 | 1.1 | GO:0031996 | thioesterase binding(GO:0031996) |
0.1 | 1.5 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
0.1 | 3.5 | GO:0005109 | frizzled binding(GO:0005109) |
0.1 | 2.0 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
0.1 | 11.5 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
0.1 | 0.4 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
0.1 | 1.7 | GO:0034185 | apolipoprotein binding(GO:0034185) |
0.1 | 0.5 | GO:0004614 | phosphoglucomutase activity(GO:0004614) |
0.1 | 5.4 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
0.0 | 0.3 | GO:0052654 | branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656) |
0.0 | 2.0 | GO:0004521 | endoribonuclease activity(GO:0004521) |
0.0 | 0.4 | GO:0015037 | peptide disulfide oxidoreductase activity(GO:0015037) |
0.0 | 0.9 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
0.0 | 0.4 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
0.0 | 1.1 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
0.0 | 1.5 | GO:0035064 | methylated histone binding(GO:0035064) |
0.0 | 0.7 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
0.0 | 1.6 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
0.0 | 0.3 | GO:0002161 | aminoacyl-tRNA editing activity(GO:0002161) |
0.0 | 0.2 | GO:0043495 | protein anchor(GO:0043495) |
0.0 | 13.1 | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981) |
0.0 | 0.2 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
0.0 | 4.7 | GO:0005096 | GTPase activator activity(GO:0005096) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.7 | 90.5 | PID_IGF1_PATHWAY | IGF1 pathway |
0.5 | 4.3 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
0.3 | 12.0 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
0.3 | 8.7 | PID_P38_MKK3_6PATHWAY | p38 MAPK signaling pathway |
0.2 | 15.2 | PID_HES_HEY_PATHWAY | Notch-mediated HES/HEY network |
0.1 | 2.6 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
0.1 | 0.9 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
0.1 | 6.1 | PID_MYC_ACTIV_PATHWAY | Validated targets of C-MYC transcriptional activation |
0.0 | 1.5 | PID_INTEGRIN_A4B1_PATHWAY | Alpha4 beta1 integrin signaling events |
0.0 | 4.7 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
0.0 | 2.4 | WNT_SIGNALING | Genes related to Wnt-mediated signal transduction |
0.0 | 0.9 | PID_NOTCH_PATHWAY | Notch signaling pathway |
0.0 | 0.4 | PID_AURORA_A_PATHWAY | Aurora A signaling |
0.0 | 0.5 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
4.3 | 90.5 | REACTOME_SIGNAL_ATTENUATION | Genes involved in Signal attenuation |
0.4 | 4.3 | REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
0.3 | 4.7 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
0.1 | 5.5 | REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
0.1 | 1.7 | REACTOME_CALNEXIN_CALRETICULIN_CYCLE | Genes involved in Calnexin/calreticulin cycle |
0.1 | 2.0 | REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
0.1 | 1.1 | REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ | Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins |
0.1 | 12.3 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
0.1 | 1.5 | REACTOME_SULFUR_AMINO_ACID_METABOLISM | Genes involved in Sulfur amino acid metabolism |
0.1 | 0.4 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
0.0 | 1.1 | REACTOME_PYRIMIDINE_METABOLISM | Genes involved in Pyrimidine metabolism |
0.0 | 3.9 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
0.0 | 0.9 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
0.0 | 7.4 | REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
0.0 | 2.0 | REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
0.0 | 0.4 | REACTOME_REGULATION_OF_AMPK_ACTIVITY_VIA_LKB1 | Genes involved in Regulation of AMPK activity via LKB1 |
0.0 | 0.5 | REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
0.0 | 0.3 | REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM | Genes involved in Branched-chain amino acid catabolism |