Motif ID: Zbtb12

Z-value: 0.507


Transcription factors associated with Zbtb12:

Gene SymbolEntrez IDGene Name
Zbtb12 ENSMUSG00000049823.8 Zbtb12

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zbtb12mm10_v2_chr17_+_34894515_348945730.144.0e-01Click!


Activity profile for motif Zbtb12.

activity profile for motif Zbtb12


Sorted Z-values histogram for motif Zbtb12

Sorted Z-values for motif Zbtb12



Network of associatons between targets according to the STRING database.



First level regulatory network of Zbtb12

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_59260878 3.541 ENSMUST00000026084.3
Slc18a2
solute carrier family 18 (vesicular monoamine), member 2
chr11_-_12027958 3.412 ENSMUST00000109654.1
Grb10
growth factor receptor bound protein 10
chr14_-_103844173 2.995 ENSMUST00000022718.3
Ednrb
endothelin receptor type B
chr17_-_15375969 2.587 ENSMUST00000014917.7
Dll1
delta-like 1 (Drosophila)
chr6_-_124814288 2.268 ENSMUST00000172132.2
Tpi1
triosephosphate isomerase 1
chr3_+_88081997 1.835 ENSMUST00000071812.5
Iqgap3
IQ motif containing GTPase activating protein 3
chr3_-_84155762 1.483 ENSMUST00000047368.6
Mnd1
meiotic nuclear divisions 1 homolog (S. cerevisiae)
chr17_-_27029009 1.443 ENSMUST00000078691.5
Bak1
BCL2-antagonist/killer 1
chr11_+_54902743 1.419 ENSMUST00000082430.3
Gpx3
glutathione peroxidase 3
chr11_+_54902917 1.372 ENSMUST00000149324.1
Gpx3
glutathione peroxidase 3
chr13_+_104229366 1.248 ENSMUST00000022227.6
Cenpk
centromere protein K
chr8_-_45382198 1.109 ENSMUST00000093526.6
Fam149a
family with sequence similarity 149, member A
chr5_+_92603039 1.092 ENSMUST00000050952.3
Stbd1
starch binding domain 1
chr4_+_32983417 1.056 ENSMUST00000084747.5
Rragd
Ras-related GTP binding D
chr11_-_88718078 0.972 ENSMUST00000092794.5
Msi2
musashi RNA-binding protein 2
chr18_-_70472429 0.960 ENSMUST00000067556.3
4930503L19Rik
RIKEN cDNA 4930503L19 gene
chr6_+_90462562 0.736 ENSMUST00000032174.5
Klf15
Kruppel-like factor 15
chr2_-_28916668 0.691 ENSMUST00000113847.1
Barhl1
BarH-like 1 (Drosophila)
chr4_-_151057933 0.593 ENSMUST00000030797.3
Vamp3
vesicle-associated membrane protein 3
chr9_+_22411515 0.591 ENSMUST00000058868.7
9530077C05Rik
RIKEN cDNA 9530077C05 gene
chr2_+_31759993 0.541 ENSMUST00000124089.1
Abl1
c-abl oncogene 1, non-receptor tyrosine kinase
chr16_-_33967032 0.531 ENSMUST00000023510.6
Umps
uridine monophosphate synthetase
chr14_+_79481164 0.457 ENSMUST00000040131.5
Elf1
E74-like factor 1
chr2_+_31759932 0.428 ENSMUST00000028190.6
Abl1
c-abl oncogene 1, non-receptor tyrosine kinase
chr7_+_92875253 0.417 ENSMUST00000076052.6
Prcp
prolylcarboxypeptidase (angiotensinase C)
chr18_-_46728342 0.361 ENSMUST00000035804.7
Cdo1
cysteine dioxygenase 1, cytosolic
chr6_+_108065035 0.338 ENSMUST00000049246.6
Setmar
SET domain without mariner transposase fusion
chr1_+_69826986 0.301 ENSMUST00000065425.5
ENSMUST00000113940.2
Spag16

sperm associated antigen 16

chr5_+_30281377 0.288 ENSMUST00000101448.3
Drc1
dynein regulatory complex subunit 1
chr19_-_10240689 0.257 ENSMUST00000088013.5
Myrf
myelin regulatory factor
chr15_-_88954400 0.235 ENSMUST00000109371.1
Ttll8
tubulin tyrosine ligase-like family, member 8
chr17_-_56874421 0.220 ENSMUST00000043062.4
Acsbg2
acyl-CoA synthetase bubblegum family member 2
chr1_+_37997975 0.217 ENSMUST00000027252.7
Eif5b
eukaryotic translation initiation factor 5B
chr7_-_127993831 0.207 ENSMUST00000033056.3
Pycard
PYD and CARD domain containing
chr17_+_27909337 0.184 ENSMUST00000114842.1
ENSMUST00000025058.7
ENSMUST00000088027.5
Anks1


ankyrin repeat and SAM domain containing 1


chr5_+_67260696 0.178 ENSMUST00000161233.1
ENSMUST00000160352.1
Tmem33

transmembrane protein 33

chr4_-_133633419 0.172 ENSMUST00000084238.4
Zdhhc18
zinc finger, DHHC domain containing 18
chr3_-_130061553 0.154 ENSMUST00000168675.1
Sec24b
Sec24 related gene family, member B (S. cerevisiae)
chr17_-_27909206 0.145 ENSMUST00000114848.1
Taf11
TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr12_-_101958148 0.135 ENSMUST00000159883.1
ENSMUST00000160251.1
ENSMUST00000161011.1
ENSMUST00000021606.5
Atxn3



ataxin 3



chr10_-_86011833 0.134 ENSMUST00000105304.1
ENSMUST00000061699.5
Bpifc

BPI fold containing family C

chr15_+_82341179 0.124 ENSMUST00000050349.2
Fam109b
family with sequence similarity 109, member B
chr6_+_37900477 0.122 ENSMUST00000120238.1
Trim24
tripartite motif-containing 24
chr17_-_32189457 0.119 ENSMUST00000087721.3
ENSMUST00000162117.1
Ephx3

epoxide hydrolase 3

chr6_-_33060172 0.111 ENSMUST00000115091.1
ENSMUST00000127666.1
Chchd3

coiled-coil-helix-coiled-coil-helix domain containing 3

chr11_-_100441795 0.109 ENSMUST00000107398.1
Nt5c3b
5'-nucleotidase, cytosolic IIIB
chr12_+_105784694 0.103 ENSMUST00000109901.2
ENSMUST00000168186.1
ENSMUST00000163473.1
ENSMUST00000170540.1
ENSMUST00000166735.1
ENSMUST00000170002.1
Papola





poly (A) polymerase alpha





chr11_+_98446826 0.082 ENSMUST00000019456.4
Grb7
growth factor receptor bound protein 7
chr4_-_119173849 0.077 ENSMUST00000052715.4
ENSMUST00000179290.1
ENSMUST00000154226.1
Zfp691


zinc finger protein 691


chr5_+_95956916 0.060 ENSMUST00000023840.5
Cxcl13
chemokine (C-X-C motif) ligand 13
chr3_+_5218589 0.060 ENSMUST00000177488.1
Zfhx4
zinc finger homeodomain 4
chrX_-_140956675 0.055 ENSMUST00000033805.8
ENSMUST00000112978.1
Psmd10

proteasome (prosome, macropain) 26S subunit, non-ATPase, 10

chr7_-_25477607 0.016 ENSMUST00000098669.1
ENSMUST00000098668.1
ENSMUST00000098666.2
Ceacam1


carcinoembryonic antigen-related cell adhesion molecule 1


chrX_+_94724569 0.001 ENSMUST00000101388.2
Zxdb
zinc finger, X-linked, duplicated B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.0 GO:0014826 vein smooth muscle contraction(GO:0014826)
0.9 2.6 GO:0001757 somite specification(GO:0001757) arterial endothelial cell fate commitment(GO:0060844) blood vessel endothelial cell fate commitment(GO:0060846) endothelial cell fate specification(GO:0060847) Notch signaling pathway involved in arterial endothelial cell fate commitment(GO:0060853) blood vessel endothelial cell fate specification(GO:0097101)
0.8 2.3 GO:0019405 alditol catabolic process(GO:0019405) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.6 3.5 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.5 1.4 GO:0010248 B cell negative selection(GO:0002352) establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
0.4 3.4 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.3 1.0 GO:1900275 negative regulation of phospholipase C activity(GO:1900275)
0.2 1.8 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.2 0.5 GO:0009174 UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.1 2.8 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.1 1.1 GO:0043201 response to leucine(GO:0043201) cellular response to leucine(GO:0071233)
0.1 0.2 GO:0018094 protein polyglycylation(GO:0018094)
0.1 0.4 GO:0033762 response to glucagon(GO:0033762)
0.1 0.2 GO:0002586 positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002582) regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002586) positive regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002588)
0.1 0.2 GO:1901187 regulation of ephrin receptor signaling pathway(GO:1901187)
0.1 0.3 GO:0051012 microtubule sliding(GO:0051012)
0.1 0.2 GO:1903896 positive regulation of IRE1-mediated unfolded protein response(GO:1903896)
0.1 1.1 GO:0005980 polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.0 0.4 GO:0002154 thyroid hormone mediated signaling pathway(GO:0002154) regulation of thyroid hormone mediated signaling pathway(GO:0002155)
0.0 0.7 GO:0072112 renal filtration cell differentiation(GO:0061318) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0 1.5 GO:0007131 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.0 0.2 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.0 0.6 GO:0035493 SNARE complex assembly(GO:0035493)
0.0 0.1 GO:2001027 negative regulation of endothelial cell chemotaxis(GO:2001027)
0.0 0.5 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.3 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.0 0.1 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.0 0.1 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.0 0.3 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.0 0.1 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.0 0.7 GO:0030901 midbrain development(GO:0030901)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.2 3.5 GO:0031045 dense core granule(GO:0031045)
0.1 1.4 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 0.2 GO:0061702 inflammasome complex(GO:0061702)
0.0 1.9 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.1 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.3 GO:0044447 axoneme part(GO:0044447)
0.0 0.6 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.0 1.0 GO:0005844 polysome(GO:0005844)
0.0 0.1 GO:0061617 MICOS complex(GO:0061617)
0.0 0.1 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 0.4 GO:0045178 basal part of cell(GO:0045178)
0.0 3.0 GO:0031965 nuclear membrane(GO:0031965)
0.0 0.2 GO:0030127 COPII vesicle coat(GO:0030127)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.5 GO:0008504 monoamine transmembrane transporter activity(GO:0008504)
1.0 3.0 GO:0004962 endothelin receptor activity(GO:0004962)
0.4 1.8 GO:0032027 myosin light chain binding(GO:0032027)
0.3 1.1 GO:2001069 glycogen binding(GO:2001069)
0.3 2.8 GO:0008430 selenium binding(GO:0008430)
0.2 2.3 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.2 2.6 GO:0030957 Tat protein binding(GO:0030957)
0.1 1.4 GO:0051400 BH domain binding(GO:0051400)
0.1 1.0 GO:0070097 delta-catenin binding(GO:0070097)
0.1 0.2 GO:0070736 protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736)
0.1 0.4 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 2.7 GO:0005158 insulin receptor binding(GO:0005158)
0.0 1.0 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.4 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0 0.2 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.0 0.6 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.1 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.1 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.1 GO:0031735 CCR10 chemokine receptor binding(GO:0031735)
0.0 0.1 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.9 GO:0019003 GDP binding(GO:0019003)
0.0 0.2 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.0 0.5 GO:0016831 carboxy-lyase activity(GO:0016831)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 3.4 PID_IGF1_PATHWAY IGF1 pathway
0.1 3.6 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 2.6 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.0 1.8 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 1.0 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.5 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 1.1 PID_MTOR_4PATHWAY mTOR signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.5 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.2 2.6 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.2 3.4 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.1 2.3 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.4 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 1.5 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.0 3.1 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.2 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 1.4 REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 1.0 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 0.5 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.0 1.2 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.4 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism