Motif ID: Zfp423

Z-value: 0.437


Transcription factors associated with Zfp423:

Gene SymbolEntrez IDGene Name
Zfp423 ENSMUSG00000045333.9 Zfp423

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zfp423mm10_v2_chr8_-_87804411_878044630.221.7e-01Click!


Activity profile for motif Zfp423.

activity profile for motif Zfp423


Sorted Z-values histogram for motif Zfp423

Sorted Z-values for motif Zfp423



Network of associatons between targets according to the STRING database.



First level regulatory network of Zfp423

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_6863769 1.460 ENSMUST00000031768.6
Dlx6
distal-less homeobox 6
chr11_+_54902743 1.093 ENSMUST00000082430.3
Gpx3
glutathione peroxidase 3
chr12_+_109459843 1.050 ENSMUST00000173812.1
Dlk1
delta-like 1 homolog (Drosophila)
chr1_+_167598450 0.903 ENSMUST00000111386.1
ENSMUST00000111384.1
Rxrg

retinoid X receptor gamma

chr8_+_27260327 0.872 ENSMUST00000033880.5
Eif4ebp1
eukaryotic translation initiation factor 4E binding protein 1
chr9_-_37552904 0.866 ENSMUST00000065668.5
Nrgn
neurogranin
chr8_+_58912257 0.856 ENSMUST00000160055.1
BC030500
cDNA sequence BC030500
chr2_+_180499893 0.780 ENSMUST00000029084.2
Ntsr1
neurotensin receptor 1
chr11_+_54902917 0.772 ENSMUST00000149324.1
Gpx3
glutathione peroxidase 3
chr17_-_32166879 0.731 ENSMUST00000087723.3
Notch3
notch 3
chr6_+_110645572 0.708 ENSMUST00000071076.6
ENSMUST00000172951.1
Grm7

glutamate receptor, metabotropic 7

chr19_+_6401675 0.672 ENSMUST00000113471.1
ENSMUST00000113469.2
Rasgrp2

RAS, guanyl releasing protein 2

chr7_+_29307924 0.640 ENSMUST00000108230.1
ENSMUST00000065181.5
Dpf1

D4, zinc and double PHD fingers family 1

chr16_+_17489639 0.635 ENSMUST00000023448.6
Aifm3
apoptosis-inducing factor, mitochondrion-associated 3
chrX_+_7822289 0.634 ENSMUST00000009875.4
Kcnd1
potassium voltage-gated channel, Shal-related family, member 1
chr4_-_106464167 0.620 ENSMUST00000049507.5
Pcsk9
proprotein convertase subtilisin/kexin type 9
chr4_+_42917234 0.610 ENSMUST00000107976.2
ENSMUST00000069184.2
N28178

expressed sequence N28178

chr1_+_167598384 0.550 ENSMUST00000015987.3
Rxrg
retinoid X receptor gamma
chr2_-_147085445 0.524 ENSMUST00000067020.2
Nkx2-4
NK2 homeobox 4
chr10_+_82954344 0.516 ENSMUST00000095396.3
Gm4799
predicted gene 4799
chr10_-_62110945 0.514 ENSMUST00000142821.1
ENSMUST00000124615.1
ENSMUST00000064050.4
ENSMUST00000125704.1
ENSMUST00000142796.1
2010107G23Rik




RIKEN cDNA 2010107G23 gene




chr11_+_11115784 0.485 ENSMUST00000056344.4
Vwc2
von Willebrand factor C domain containing 2
chr19_+_10041548 0.484 ENSMUST00000115995.2
Fads3
fatty acid desaturase 3
chr17_-_10840285 0.477 ENSMUST00000041463.6
Pacrg
PARK2 co-regulated
chrX_+_58030999 0.424 ENSMUST00000088631.4
ENSMUST00000088629.3
Zic3

zinc finger protein of the cerebellum 3

chr4_+_129513581 0.423 ENSMUST00000062356.6
Marcksl1
MARCKS-like 1
chr11_-_33203588 0.419 ENSMUST00000037746.6
Tlx3
T cell leukemia, homeobox 3
chr9_+_120492606 0.413 ENSMUST00000007139.4
Eif1b
eukaryotic translation initiation factor 1B
chr6_+_86628174 0.390 ENSMUST00000043400.6
Asprv1
aspartic peptidase, retroviral-like 1
chr10_+_3973086 0.385 ENSMUST00000117291.1
ENSMUST00000120585.1
ENSMUST00000043735.7
Mthfd1l


methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like


chrX_+_58030622 0.378 ENSMUST00000088627.4
Zic3
zinc finger protein of the cerebellum 3
chr17_-_29347902 0.368 ENSMUST00000095427.4
ENSMUST00000118366.1
Mtch1

mitochondrial carrier homolog 1 (C. elegans)

chr11_-_106160101 0.364 ENSMUST00000045923.3
Limd2
LIM domain containing 2
chr12_-_69183986 0.362 ENSMUST00000110620.1
ENSMUST00000110619.1
Rpl36al

ribosomal protein L36A-like

chrX_-_75130996 0.321 ENSMUST00000033775.2
Mpp1
membrane protein, palmitoylated
chr12_-_69184056 0.317 ENSMUST00000054544.6
Rpl36al
ribosomal protein L36A-like
chr7_-_70360593 0.303 ENSMUST00000032768.7
Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr7_-_105744312 0.302 ENSMUST00000141116.1
Taf10
TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr7_-_120670256 0.298 ENSMUST00000033178.2
Pdzd9
PDZ domain containing 9
chr2_+_13573927 0.271 ENSMUST00000141365.1
ENSMUST00000028062.2
Vim

vimentin

chr7_-_5014645 0.255 ENSMUST00000165320.1
Fiz1
Flt3 interacting zinc finger protein 1
chr1_-_51941261 0.253 ENSMUST00000097103.3
Gm8420
predicted gene 8420
chr5_-_22344690 0.253 ENSMUST00000062372.7
ENSMUST00000161356.1
Reln

reelin

chr2_-_180889660 0.241 ENSMUST00000137629.1
Gm14342
predicted gene 14342
chr13_-_47106176 0.236 ENSMUST00000021807.6
ENSMUST00000135278.1
Dek

DEK oncogene (DNA binding)

chr7_-_105633525 0.224 ENSMUST00000153371.1
ENSMUST00000106789.1
ENSMUST00000057525.7
Trim3


tripartite motif-containing 3


chr4_+_129820198 0.213 ENSMUST00000030578.7
Ptp4a2
protein tyrosine phosphatase 4a2
chr16_+_58408443 0.190 ENSMUST00000046663.7
Dcbld2
discoidin, CUB and LCCL domain containing 2
chr11_-_115536181 0.185 ENSMUST00000118155.1
ENSMUST00000153892.1
Sumo2

SMT3 suppressor of mif two 3 homolog 2 (yeast)

chr7_-_141443314 0.182 ENSMUST00000106005.2
Lrdd
leucine-rich and death domain containing
chr11_+_102836296 0.180 ENSMUST00000021302.8
ENSMUST00000107072.1
Higd1b

HIG1 domain family, member 1B

chr18_+_4920509 0.179 ENSMUST00000126977.1
Svil
supervillin
chr7_-_34196608 0.173 ENSMUST00000148381.1
ENSMUST00000002710.3
Pdcd2l

programmed cell death 2-like

chr11_-_115535804 0.166 ENSMUST00000117589.1
ENSMUST00000121185.1
Sumo2

SMT3 suppressor of mif two 3 homolog 2 (yeast)

chr11_+_82101836 0.150 ENSMUST00000000194.3
Ccl12
chemokine (C-C motif) ligand 12
chr6_-_124756478 0.148 ENSMUST00000088357.5
Atn1
atrophin 1
chr7_+_45705518 0.138 ENSMUST00000107740.1
ENSMUST00000107741.1
Dbp

D site albumin promoter binding protein

chr5_+_115429944 0.117 ENSMUST00000067168.5
Msi1
musashi RNA-binding protein 1
chr8_-_94012558 0.115 ENSMUST00000053766.6
Amfr
autocrine motility factor receptor
chr4_-_148626756 0.104 ENSMUST00000105699.1
Tardbp
TAR DNA binding protein
chr17_+_86963077 0.104 ENSMUST00000024956.8
Rhoq
ras homolog gene family, member Q
chr17_+_55986494 0.099 ENSMUST00000011733.8
Fsd1
fibronectin type 3 and SPRY domain-containing protein
chrX_-_75130844 0.098 ENSMUST00000114092.1
ENSMUST00000132501.1
ENSMUST00000153318.1
ENSMUST00000155742.1
Mpp1



membrane protein, palmitoylated



chr12_+_69184158 0.096 ENSMUST00000060579.8
Mgat2
mannoside acetylglucosaminyltransferase 2
chr5_-_135934590 0.089 ENSMUST00000055808.5
Ywhag
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
chr10_-_14705459 0.083 ENSMUST00000149485.1
ENSMUST00000154132.1
Vta1

Vps20-associated 1 homolog (S. cerevisiae)

chr7_+_127485221 0.082 ENSMUST00000048896.6
Fbrs
fibrosin
chr13_+_3538075 0.078 ENSMUST00000059515.6
Gdi2
guanosine diphosphate (GDP) dissociation inhibitor 2
chr19_-_10869757 0.061 ENSMUST00000120524.1
ENSMUST00000025645.7
Tmem132a

transmembrane protein 132A

chr14_+_119138415 0.054 ENSMUST00000065904.3
Hs6st3
heparan sulfate 6-O-sulfotransferase 3
chr2_-_30359278 0.054 ENSMUST00000163668.2
ENSMUST00000028214.8
ENSMUST00000113621.3
Sh3glb2


SH3-domain GRB2-like endophilin B2


chr2_-_30359190 0.048 ENSMUST00000100215.4
ENSMUST00000113620.3
Sh3glb2

SH3-domain GRB2-like endophilin B2

chr14_+_70553687 0.044 ENSMUST00000161069.1
Hr
hairless
chr2_+_106693185 0.041 ENSMUST00000111063.1
Mpped2
metallophosphoesterase domain containing 2
chr7_-_105633479 0.037 ENSMUST00000147044.1
ENSMUST00000106791.1
Trim3

tripartite motif-containing 3

chr2_+_164785823 0.035 ENSMUST00000174070.1
ENSMUST00000172577.1
ENSMUST00000056181.6
Snx21


sorting nexin family member 21


chr5_+_24423805 0.011 ENSMUST00000153274.1
Slc4a2
solute carrier family 4 (anion exchanger), member 2
chrX_-_75130914 0.006 ENSMUST00000114091.1
Mpp1
membrane protein, palmitoylated
chr15_-_78718113 0.002 ENSMUST00000088592.4
Elfn2
leucine rich repeat and fibronectin type III, extracellular 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0090238 positive regulation of arachidonic acid secretion(GO:0090238)
0.2 0.6 GO:0001920 negative regulation of receptor recycling(GO:0001920) negative regulation of low-density lipoprotein particle clearance(GO:0010989) positive regulation of low-density lipoprotein particle receptor catabolic process(GO:0032805)
0.1 0.9 GO:1990928 response to amino acid starvation(GO:1990928)
0.1 0.7 GO:0001661 conditioned taste aversion(GO:0001661)
0.1 0.8 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.1 0.7 GO:0072103 glomerulus vasculature morphogenesis(GO:0072103) glomerular capillary formation(GO:0072104)
0.1 1.9 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.1 0.4 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.1 0.3 GO:0097477 lateral motor column neuron migration(GO:0097477)
0.1 0.3 GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.1 0.3 GO:1900147 Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
0.1 0.3 GO:0070365 hepatocyte differentiation(GO:0070365)
0.0 0.1 GO:2000501 natural killer cell chemotaxis(GO:0035747) negative regulation of lymphocyte migration(GO:2000402) regulation of natural killer cell chemotaxis(GO:2000501)
0.0 0.2 GO:2001032 regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.0 1.0 GO:0045780 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.0 0.1 GO:0009405 pathogenesis(GO:0009405)
0.0 1.0 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 0.4 GO:0002087 regulation of respiratory gaseous exchange by neurological system process(GO:0002087)
0.0 0.9 GO:1900273 positive regulation of long-term synaptic potentiation(GO:1900273)
0.0 0.1 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.0 0.4 GO:0033235 positive regulation of protein sumoylation(GO:0033235)
0.0 0.4 GO:0090022 regulation of neutrophil chemotaxis(GO:0090022)
0.0 1.5 GO:0060021 palate development(GO:0060021)
0.0 0.1 GO:0043922 negative regulation by host of viral transcription(GO:0043922)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.2 0.8 GO:0032280 symmetric synapse(GO:0032280)
0.1 0.3 GO:0045098 type III intermediate filament(GO:0045098)
0.1 0.9 GO:0044327 dendritic spine head(GO:0044327)
0.1 0.7 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.1 0.3 GO:0000125 PCAF complex(GO:0000125)
0.0 0.5 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.6 GO:0071565 nBAF complex(GO:0071565)
0.0 0.5 GO:0097225 sperm midpiece(GO:0097225)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0070905 serine binding(GO:0070905)
0.2 0.6 GO:0034190 very-low-density lipoprotein particle binding(GO:0034189) apolipoprotein receptor binding(GO:0034190)
0.2 1.9 GO:0008430 selenium binding(GO:0008430)
0.1 1.5 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 0.6 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.1 0.4 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.1 0.9 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.1 0.3 GO:1990254 keratin filament binding(GO:1990254)
0.1 0.3 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.0 0.9 GO:0070300 phosphatidic acid binding(GO:0070300)
0.0 0.8 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.0 0.1 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.0 0.3 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.4 GO:0031386 protein tag(GO:0031386)
0.0 0.1 GO:1904288 BAT3 complex binding(GO:1904288)
0.0 0.6 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.4 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.1 GO:0005093 Rab GDP-dissociation inhibitor activity(GO:0005093)
0.0 0.5 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.1 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.5 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.5 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.0 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.7 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 0.6 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.3 PID_MYC_PATHWAY C-MYC pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.1 0.7 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 0.7 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 1.0 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 1.5 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.7 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.0 0.6 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.3 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins