Motif ID: Mef2b

Z-value: 0.711


Transcription factors associated with Mef2b:

Gene SymbolEntrez IDGene Name
Mef2b ENSMUSG00000079033.3 Mef2b

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mef2bmm10_v2_chr8_+_70152754_701527810.381.3e-02Click!


Activity profile for motif Mef2b.

activity profile for motif Mef2b


Sorted Z-values histogram for motif Mef2b

Sorted Z-values for motif Mef2b



Network of associatons between targets according to the STRING database.



First level regulatory network of Mef2b

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_23248264 6.677 ENSMUST00000031709.5
Fezf1
Fez family zinc finger 1
chr7_-_142899985 5.349 ENSMUST00000000219.3
Th
tyrosine hydroxylase
chr7_-_103843154 3.850 ENSMUST00000063957.4
Hbb-bh1
hemoglobin Z, beta-like embryonic chain
chrY_-_1286563 3.839 ENSMUST00000091190.5
Ddx3y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr2_-_172043466 3.729 ENSMUST00000087950.3
Cbln4
cerebellin 4 precursor protein
chr18_+_60963517 3.180 ENSMUST00000115295.2
ENSMUST00000039904.6
Camk2a

calcium/calmodulin-dependent protein kinase II alpha

chr1_+_187609028 3.014 ENSMUST00000110939.1
Esrrg
estrogen-related receptor gamma
chr12_-_111672290 2.905 ENSMUST00000001304.7
Ckb
creatine kinase, brain
chr7_-_144738478 2.645 ENSMUST00000121758.1
Ano1
anoctamin 1, calcium activated chloride channel
chr18_+_50030977 2.420 ENSMUST00000145726.1
ENSMUST00000128377.1
Tnfaip8

tumor necrosis factor, alpha-induced protein 8

chr2_-_94264713 2.171 ENSMUST00000129661.1
E530001K10Rik
RIKEN cDNA E530001K10 gene
chr3_+_40800013 2.111 ENSMUST00000026858.5
ENSMUST00000170825.1
Plk4

polo-like kinase 4

chrX_+_10717390 2.049 ENSMUST00000115524.1
ENSMUST00000008179.6
Mid1ip1

Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish))

chr8_+_31089471 1.970 ENSMUST00000036631.7
ENSMUST00000170204.1
Dusp26

dual specificity phosphatase 26 (putative)

chr5_+_24985840 1.965 ENSMUST00000075081.6
1500035N22Rik
RIKEN cDNA 1500035N22 gene
chr9_-_110742577 1.947 ENSMUST00000006005.7
Pth1r
parathyroid hormone 1 receptor
chrX_+_10717451 1.923 ENSMUST00000156321.1
Mid1ip1
Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish))
chr2_-_94264745 1.862 ENSMUST00000134563.1
E530001K10Rik
RIKEN cDNA E530001K10 gene
chr2_-_57124003 1.848 ENSMUST00000112629.1
Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr7_-_144738520 1.744 ENSMUST00000118556.2
ENSMUST00000033393.8
Ano1

anoctamin 1, calcium activated chloride channel

chr17_-_58991343 1.739 ENSMUST00000025064.7
2610034M16Rik
RIKEN cDNA 2610034M16 gene
chr13_+_5861489 1.685 ENSMUST00000000080.6
Klf6
Kruppel-like factor 6
chr4_-_95052188 1.625 ENSMUST00000107094.1
Jun
Jun oncogene
chr7_-_100514800 1.610 ENSMUST00000054923.7
Dnajb13
DnaJ (Hsp40) related, subfamily B, member 13
chr4_-_95052170 1.600 ENSMUST00000058555.2
Jun
Jun oncogene
chr17_+_34039437 1.587 ENSMUST00000131134.1
ENSMUST00000087497.4
ENSMUST00000114255.1
ENSMUST00000114252.1
Col11a2



collagen, type XI, alpha 2



chrX_+_142825698 1.536 ENSMUST00000112888.1
Tmem164
transmembrane protein 164
chr13_-_23698454 1.509 ENSMUST00000102967.1
Hist1h4c
histone cluster 1, H4c
chr6_-_126939524 1.508 ENSMUST00000144954.1
ENSMUST00000112221.1
ENSMUST00000112220.1
Rad51ap1


RAD51 associated protein 1


chr4_-_9643638 1.382 ENSMUST00000108333.1
ENSMUST00000108334.1
ENSMUST00000108335.1
ENSMUST00000152526.1
ENSMUST00000103004.3
Asph




aspartate-beta-hydroxylase




chr9_-_110654161 1.380 ENSMUST00000133191.1
ENSMUST00000167320.1
Nbeal2

neurobeachin-like 2

chr5_-_128953303 1.352 ENSMUST00000111346.1
Rimbp2
RIMS binding protein 2
chr3_-_138143352 1.341 ENSMUST00000098580.2
Mttp
microsomal triglyceride transfer protein
chrX_-_93832106 1.341 ENSMUST00000045748.6
Pdk3
pyruvate dehydrogenase kinase, isoenzyme 3
chrX_+_75096039 1.332 ENSMUST00000131155.1
ENSMUST00000132000.1
Dkc1

dyskeratosis congenita 1, dyskerin

chr9_+_99629496 1.329 ENSMUST00000131095.1
ENSMUST00000078367.5
ENSMUST00000112885.2
Dzip1l


DAZ interacting protein 1-like


chr7_+_81862674 1.270 ENSMUST00000119543.1
Tm6sf1
transmembrane 6 superfamily member 1
chrX_+_75095854 1.264 ENSMUST00000033776.8
Dkc1
dyskeratosis congenita 1, dyskerin
chr3_-_20155069 1.252 ENSMUST00000184552.1
ENSMUST00000178328.1
Gyg

glycogenin

chr19_-_36919606 1.181 ENSMUST00000057337.7
Fgfbp3
fibroblast growth factor binding protein 3
chr9_+_99629823 1.179 ENSMUST00000112886.2
Dzip1l
DAZ interacting protein 1-like
chr16_-_23127702 1.173 ENSMUST00000115338.1
ENSMUST00000115337.1
ENSMUST00000023598.8
Rfc4


replication factor C (activator 1) 4


chr6_+_137410721 1.173 ENSMUST00000167002.1
Ptpro
protein tyrosine phosphatase, receptor type, O
chr5_+_21785253 1.171 ENSMUST00000030769.5
Psmc2
proteasome (prosome, macropain) 26S subunit, ATPase 2
chr10_-_128549125 1.097 ENSMUST00000177163.1
ENSMUST00000176683.1
ENSMUST00000176010.1
Rpl41


ribosomal protein L41


chr3_-_150073620 1.090 ENSMUST00000057740.5
Rpsa-ps10
ribosomal protein SA, pseudogene 10
chr19_-_34879452 1.087 ENSMUST00000036584.5
Pank1
pantothenate kinase 1
chr3_+_138143429 1.045 ENSMUST00000040321.6
Trmt10a
tRNA methyltransferase 10A
chr2_+_91255954 1.019 ENSMUST00000134699.1
Pacsin3
protein kinase C and casein kinase substrate in neurons 3
chr10_-_128549102 1.019 ENSMUST00000176906.1
Rpl41
ribosomal protein L41
chr3_+_89459118 0.993 ENSMUST00000029564.5
Pmvk
phosphomevalonate kinase
chr2_+_164486856 0.969 ENSMUST00000109349.2
Dbndd2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr1_-_172329261 0.948 ENSMUST00000062387.2
Kcnj9
potassium inwardly-rectifying channel, subfamily J, member 9
chr5_-_16731074 0.947 ENSMUST00000073014.5
Gm8991
predicted pseudogene 8991
chr4_+_62663620 0.902 ENSMUST00000126338.1
Rgs3
regulator of G-protein signaling 3
chr10_+_80629646 0.859 ENSMUST00000085435.5
Csnk1g2
casein kinase 1, gamma 2
chr3_+_96596628 0.849 ENSMUST00000058943.7
Ankrd34a
ankyrin repeat domain 34A
chr3_+_89459325 0.834 ENSMUST00000107410.1
Pmvk
phosphomevalonate kinase
chr3_+_96645579 0.807 ENSMUST00000119365.1
ENSMUST00000029744.5
Itga10

integrin, alpha 10

chr3_+_32817520 0.807 ENSMUST00000072312.5
ENSMUST00000108228.1
Usp13

ubiquitin specific peptidase 13 (isopeptidase T-3)

chr5_+_25759987 0.804 ENSMUST00000128727.1
ENSMUST00000088244.4
Actr3b

ARP3 actin-related protein 3B

chr10_-_88605017 0.752 ENSMUST00000119185.1
ENSMUST00000121629.1
Mybpc1

myosin binding protein C, slow-type

chr17_+_91236787 0.746 ENSMUST00000057074.8
Gm6741
predicted gene 6741
chr2_+_120463566 0.737 ENSMUST00000028749.7
ENSMUST00000110721.1
Capn3

calpain 3

chr2_+_164486455 0.724 ENSMUST00000069385.8
ENSMUST00000143690.1
Dbndd2

dysbindin (dystrobrevin binding protein 1) domain containing 2

chr9_-_54647199 0.722 ENSMUST00000128163.1
Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr2_-_79908428 0.687 ENSMUST00000102652.3
ENSMUST00000102651.3
Pde1a

phosphodiesterase 1A, calmodulin-dependent

chr7_+_140763739 0.685 ENSMUST00000026552.7
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
chr11_-_79504078 0.670 ENSMUST00000164465.2
Omg
oligodendrocyte myelin glycoprotein
chr2_+_91256144 0.670 ENSMUST00000154959.1
ENSMUST00000059566.4
Pacsin3

protein kinase C and casein kinase substrate in neurons 3

chr11_+_94328242 0.667 ENSMUST00000021227.5
Ankrd40
ankyrin repeat domain 40
chr11_-_69948145 0.662 ENSMUST00000179298.1
ENSMUST00000018710.6
ENSMUST00000135437.1
ENSMUST00000141837.2
ENSMUST00000142500.1
Slc2a4




solute carrier family 2 (facilitated glucose transporter), member 4




chr18_-_25753852 0.651 ENSMUST00000025117.6
ENSMUST00000115816.2
Celf4

CUGBP, Elav-like family member 4

chr2_-_51149100 0.647 ENSMUST00000154545.1
ENSMUST00000017288.2
Rnd3

Rho family GTPase 3

chr2_-_79908389 0.642 ENSMUST00000090756.4
Pde1a
phosphodiesterase 1A, calmodulin-dependent
chr15_-_81843699 0.634 ENSMUST00000092020.2
Gm8444
predicted gene 8444
chr3_-_98814434 0.633 ENSMUST00000029463.6
Hsd3b6
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6
chr5_-_3596071 0.630 ENSMUST00000121877.1
Rbm48
RNA binding motif protein 48
chr3_+_96833218 0.622 ENSMUST00000128789.1
Pdzk1
PDZ domain containing 1
chr3_-_65958236 0.598 ENSMUST00000029416.7
Ccnl1
cyclin L1
chr7_+_101896817 0.584 ENSMUST00000143835.1
Anapc15
anaphase prompoting complex C subunit 15
chr2_-_80128834 0.579 ENSMUST00000102654.4
ENSMUST00000102655.3
Pde1a

phosphodiesterase 1A, calmodulin-dependent

chr16_+_4968936 0.563 ENSMUST00000090457.5
4930451G09Rik
RIKEN cDNA 4930451G09 gene
chr11_+_94327984 0.560 ENSMUST00000107818.2
ENSMUST00000051221.6
Ankrd40

ankyrin repeat domain 40

chr9_-_108649349 0.560 ENSMUST00000013338.8
Arih2
ariadne homolog 2 (Drosophila)
chr9_+_34904913 0.556 ENSMUST00000045091.6
Kirrel3
kin of IRRE like 3 (Drosophila)
chr1_-_172219715 0.538 ENSMUST00000170700.1
ENSMUST00000003554.4
Casq1

calsequestrin 1

chr6_+_48589560 0.502 ENSMUST00000181661.1
Gm5111
predicted gene 5111
chr16_-_17201490 0.498 ENSMUST00000090192.5
ENSMUST00000115700.1
Ube2l3

ubiquitin-conjugating enzyme E2L 3

chr16_-_56712825 0.491 ENSMUST00000136394.1
Tfg
Trk-fused gene
chr17_+_28692568 0.480 ENSMUST00000114752.1
Mapk14
mitogen-activated protein kinase 14
chr4_+_119108711 0.474 ENSMUST00000030398.3
Slc2a1
solute carrier family 2 (facilitated glucose transporter), member 1
chr1_-_12991109 0.456 ENSMUST00000115403.2
ENSMUST00000115402.1
Slco5a1

solute carrier organic anion transporter family, member 5A1

chrX_-_48208870 0.447 ENSMUST00000088935.3
Zdhhc9
zinc finger, DHHC domain containing 9
chr3_+_154597197 0.433 ENSMUST00000155385.1
ENSMUST00000029850.8
Cryz

crystallin, zeta

chr12_+_59130767 0.426 ENSMUST00000175877.1
Ctage5
CTAGE family, member 5
chr5_+_33018816 0.418 ENSMUST00000019109.7
Ywhah
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
chr18_+_76059458 0.417 ENSMUST00000167921.1
Zbtb7c
zinc finger and BTB domain containing 7C
chr7_-_102100227 0.402 ENSMUST00000106937.1
Art5
ADP-ribosyltransferase 5
chr19_+_21272276 0.399 ENSMUST00000025659.4
Zfand5
zinc finger, AN1-type domain 5
chr8_-_105943382 0.396 ENSMUST00000038896.7
Lcat
lecithin cholesterol acyltransferase
chr6_-_124965485 0.387 ENSMUST00000112439.2
Cops7a
COP9 (constitutive photomorphogenic) homolog, subunit 7a (Arabidopsis thaliana)
chr17_+_29032664 0.385 ENSMUST00000130216.1
Srsf3
serine/arginine-rich splicing factor 3
chr6_-_124965403 0.372 ENSMUST00000129446.1
ENSMUST00000032220.8
Cops7a

COP9 (constitutive photomorphogenic) homolog, subunit 7a (Arabidopsis thaliana)

chr15_-_50889691 0.371 ENSMUST00000165201.2
ENSMUST00000184458.1
Trps1

trichorhinophalangeal syndrome I (human)

chr13_-_23934156 0.369 ENSMUST00000052776.2
Hist1h2ba
histone cluster 1, H2ba
chr9_-_36797303 0.363 ENSMUST00000115086.5
Ei24
etoposide induced 2.4 mRNA
chr5_-_122614445 0.359 ENSMUST00000127220.1
ENSMUST00000031426.7
Ift81

intraflagellar transport 81

chr15_-_89425856 0.359 ENSMUST00000109313.2
Cpt1b
carnitine palmitoyltransferase 1b, muscle
chr5_+_140419248 0.351 ENSMUST00000100507.3
Eif3b
eukaryotic translation initiation factor 3, subunit B
chr12_+_59130994 0.325 ENSMUST00000177460.1
Ctage5
CTAGE family, member 5
chr4_+_119108795 0.317 ENSMUST00000134105.1
ENSMUST00000144329.1
Slc2a1

solute carrier family 2 (facilitated glucose transporter), member 1

chr11_+_77462325 0.300 ENSMUST00000102493.1
Coro6
coronin 6
chr11_+_105178765 0.296 ENSMUST00000106939.2
Tlk2
tousled-like kinase 2 (Arabidopsis)
chr7_-_101837776 0.296 ENSMUST00000165052.1
Inppl1
inositol polyphosphate phosphatase-like 1
chr12_+_86361112 0.294 ENSMUST00000116402.3
Esrrb
estrogen related receptor, beta
chr9_-_36797273 0.285 ENSMUST00000163192.3
Ei24
etoposide induced 2.4 mRNA
chr8_-_67515606 0.281 ENSMUST00000032981.5
Gm9755
predicted pseudogene 9755
chr11_-_101417615 0.263 ENSMUST00000070395.8
Aarsd1
alanyl-tRNA synthetase domain containing 1
chr3_+_108653979 0.261 ENSMUST00000106613.1
Clcc1
chloride channel CLIC-like 1
chr11_-_101424519 0.260 ENSMUST00000107257.1
ENSMUST00000107259.3
ENSMUST00000107252.2
ENSMUST00000093933.4
Gm27029

Ptges3l

predicted gene, 27029

prostaglandin E synthase 3 (cytosolic)-like

chr6_-_136941694 0.254 ENSMUST00000032344.5
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr15_-_89425795 0.249 ENSMUST00000168376.1
Cpt1b
carnitine palmitoyltransferase 1b, muscle
chr15_+_94629148 0.248 ENSMUST00000080141.4
Tmem117
transmembrane protein 117
chr5_-_130003000 0.243 ENSMUST00000026613.7
Gusb
glucuronidase, beta
chrX_+_159303266 0.238 ENSMUST00000112491.1
Rps6ka3
ribosomal protein S6 kinase polypeptide 3
chr11_+_70657196 0.225 ENSMUST00000157027.1
ENSMUST00000072841.5
ENSMUST00000108548.1
ENSMUST00000126241.1
Eno3



enolase 3, beta muscle



chr11_+_77801291 0.200 ENSMUST00000100794.3
Myo18a
myosin XVIIIA
chr1_+_9547948 0.196 ENSMUST00000144177.1
Adhfe1
alcohol dehydrogenase, iron containing, 1
chr2_-_26516620 0.194 ENSMUST00000132820.1
Notch1
notch 1
chr8_+_94857450 0.191 ENSMUST00000109521.3
Polr2c
polymerase (RNA) II (DNA directed) polypeptide C
chr9_+_69397897 0.191 ENSMUST00000034761.8
ENSMUST00000125938.1
Narg2

NMDA receptor-regulated gene 2

chr1_+_171437535 0.172 ENSMUST00000043839.4
F11r
F11 receptor
chr4_-_131967824 0.171 ENSMUST00000146443.1
ENSMUST00000135579.1
Epb4.1

erythrocyte protein band 4.1

chr11_-_83649349 0.168 ENSMUST00000001008.5
Ccl3
chemokine (C-C motif) ligand 3
chr4_+_156215920 0.165 ENSMUST00000105572.1
2310042D19Rik
RIKEN cDNA 2310042D19 gene
chr4_+_5724304 0.165 ENSMUST00000108380.1
Fam110b
family with sequence similarity 110, member B
chr6_+_42286676 0.163 ENSMUST00000031894.6
Clcn1
chloride channel 1
chrX_-_8252304 0.163 ENSMUST00000115594.1
Ftsj1
FtsJ homolog 1 (E. coli)
chr10_-_70592782 0.156 ENSMUST00000162251.1
Phyhipl
phytanoyl-CoA hydroxylase interacting protein-like
chr6_-_136941887 0.143 ENSMUST00000111891.1
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr3_+_154597352 0.134 ENSMUST00000140644.1
ENSMUST00000144764.1
ENSMUST00000155232.1
Cryz


crystallin, zeta


chr8_-_46211284 0.128 ENSMUST00000034049.4
Slc25a4
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4
chr10_+_111972664 0.123 ENSMUST00000163048.1
ENSMUST00000174653.1
Krr1

KRR1, small subunit (SSU) processome component, homolog (yeast)

chr2_+_91096744 0.117 ENSMUST00000132741.2
Spi1
spleen focus forming virus (SFFV) proviral integration oncogene
chr15_+_91673175 0.116 ENSMUST00000060642.6
Lrrk2
leucine-rich repeat kinase 2
chr14_-_61439831 0.115 ENSMUST00000022496.7
Kpna3
karyopherin (importin) alpha 3
chr16_+_10411928 0.113 ENSMUST00000023146.4
Nubp1
nucleotide binding protein 1
chr11_+_77801325 0.101 ENSMUST00000151373.2
ENSMUST00000172303.2
ENSMUST00000130305.2
ENSMUST00000164334.1
ENSMUST00000092884.4
Myo18a




myosin XVIIIA




chr11_+_70657687 0.083 ENSMUST00000134087.1
ENSMUST00000170716.1
Eno3

enolase 3, beta muscle

chr19_+_8723478 0.074 ENSMUST00000180819.1
ENSMUST00000181422.1
Snhg1

small nucleolar RNA host gene (non-protein coding) 1

chr12_-_81379464 0.071 ENSMUST00000062182.7
Gm4787
predicted gene 4787
chr13_-_23369156 0.059 ENSMUST00000125328.1
ENSMUST00000145451.1
ENSMUST00000050101.2
Zfp322a


zinc finger protein 322A


chr3_-_154597045 0.055 ENSMUST00000052774.1
ENSMUST00000170461.1
ENSMUST00000122976.1
Tyw3


tRNA-yW synthesizing protein 3 homolog (S. cerevisiae)


chr4_+_129287614 0.053 ENSMUST00000102599.3
Sync
syncoilin
chr18_+_60293372 0.053 ENSMUST00000171297.1
F830016B08Rik
RIKEN cDNA F830016B08 gene
chr5_+_92571477 0.038 ENSMUST00000176621.1
ENSMUST00000175974.1
ENSMUST00000131166.2
ENSMUST00000176448.1
Fam47e



family with sequence similarity 47, member E



chr8_-_111992258 0.033 ENSMUST00000034427.5
ENSMUST00000139820.1
Adat1

adenosine deaminase, tRNA-specific 1

chr7_-_84679346 0.028 ENSMUST00000069537.2
ENSMUST00000178385.1
Zfand6

zinc finger, AN1-type domain 6

chr9_+_75051977 0.024 ENSMUST00000170310.1
ENSMUST00000166549.1
Arpp19

cAMP-regulated phosphoprotein 19

chr5_+_105519388 0.022 ENSMUST00000067924.6
ENSMUST00000150981.1
Lrrc8c

leucine rich repeat containing 8 family, member C

chr2_+_172440556 0.016 ENSMUST00000029005.3
Rtfdc1
replication termination factor 2 domain containing 1
chr12_+_69241832 0.012 ENSMUST00000063445.6
Klhdc1
kelch domain containing 1
chr18_-_3281036 0.005 ENSMUST00000049942.6
ENSMUST00000139537.1
ENSMUST00000124747.1
Crem


cAMP responsive element modulator


chr14_+_73142591 0.002 ENSMUST00000170368.1
Rcbtb2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 5.3 GO:0042414 epinephrine metabolic process(GO:0042414)
1.1 6.7 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.9 4.4 GO:0015705 iodide transport(GO:0015705)
0.8 3.9 GO:0015671 oxygen transport(GO:0015671)
0.7 2.0 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.6 3.2 GO:0051365 cellular response to potassium ion starvation(GO:0051365)
0.5 1.6 GO:0060023 soft palate development(GO:0060023)
0.5 2.6 GO:0090669 snoRNA guided rRNA pseudouridine synthesis(GO:0000454) telomerase RNA stabilization(GO:0090669)
0.5 2.9 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.5 1.8 GO:0051866 general adaptation syndrome(GO:0051866)
0.5 1.4 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.5 1.4 GO:0070889 platelet alpha granule organization(GO:0070889)
0.5 1.8 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.3 1.3 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.3 2.1 GO:0098535 positive regulation of centriole replication(GO:0046601) de novo centriole assembly(GO:0098535)
0.3 0.8 GO:0035523 protein K29-linked deubiquitination(GO:0035523) protein K6-linked deubiquitination(GO:0044313)
0.3 1.3 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.3 0.8 GO:0042908 xenobiotic transport(GO:0042908)
0.2 0.7 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
0.2 3.2 GO:0099628 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
0.2 1.2 GO:0003105 negative regulation of glomerular filtration(GO:0003105)
0.2 4.0 GO:0045723 positive regulation of fatty acid biosynthetic process(GO:0045723)
0.2 0.5 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.2 1.9 GO:0060732 positive regulation of inositol phosphate biosynthetic process(GO:0060732)
0.1 1.2 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.1 1.2 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.1 0.5 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835)
0.1 0.6 GO:0002121 inter-male aggressive behavior(GO:0002121)
0.1 1.9 GO:0046069 cGMP catabolic process(GO:0046069)
0.1 0.7 GO:1902866 regulation of retina development in camera-type eye(GO:1902866)
0.1 1.2 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.1 0.6 GO:0015879 carnitine transport(GO:0015879)
0.1 1.5 GO:0036297 interstrand cross-link repair(GO:0036297)
0.1 0.3 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.1 0.6 GO:0071494 cellular response to UV-C(GO:0071494)
0.1 1.7 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 1.5 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.1 0.4 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372)
0.1 0.3 GO:1903028 regulation of opsonization(GO:1903027) positive regulation of opsonization(GO:1903028)
0.1 0.3 GO:0090282 positive regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071931) positive regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0090282)
0.1 1.1 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.1 3.8 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.1 0.4 GO:0075525 viral translational termination-reinitiation(GO:0075525)
0.1 0.4 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.1 0.2 GO:0003219 atrioventricular node development(GO:0003162) cardiac right ventricle formation(GO:0003219)
0.1 0.6 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.1 0.1 GO:2000468 regulation of peroxidase activity(GO:2000468)
0.1 3.0 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.1 0.4 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.1 0.4 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.0 2.6 GO:0032611 interleukin-1 beta production(GO:0032611)
0.0 0.8 GO:0000338 protein deneddylation(GO:0000338)
0.0 0.7 GO:0019369 arachidonic acid metabolic process(GO:0019369)
0.0 0.1 GO:0015866 ADP transport(GO:0015866)
0.0 0.3 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 0.4 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.0 0.6 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.4 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.5 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.4 GO:0006706 steroid catabolic process(GO:0006706)
0.0 0.6 GO:0042178 xenobiotic catabolic process(GO:0042178)
0.0 0.9 GO:0010107 potassium ion import(GO:0010107)
0.0 1.6 GO:0035082 axoneme assembly(GO:0035082)
0.0 0.1 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
0.0 0.7 GO:0044381 glucose import in response to insulin stimulus(GO:0044381)
0.0 0.3 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 0.7 GO:0048670 regulation of collateral sprouting(GO:0048670)
0.0 0.6 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.0 0.7 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.0 0.8 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 0.2 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.5 GO:0051443 positive regulation of ubiquitin-protein transferase activity(GO:0051443)
0.0 0.5 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.1 GO:0072697 protein localization to cell cortex(GO:0072697)
0.0 0.4 GO:0003016 respiratory system process(GO:0003016)
0.0 0.1 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 2.5 GO:0060271 cilium morphogenesis(GO:0060271)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.3 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
1.1 3.2 GO:0099573 glutamatergic postsynaptic density(GO:0099573)
0.6 2.6 GO:0090661 box H/ACA telomerase RNP complex(GO:0090661)
0.5 3.2 GO:0035976 AP1 complex(GO:0035976)
0.5 3.9 GO:0005833 hemoglobin complex(GO:0005833)
0.4 2.1 GO:0098536 deuterosome(GO:0098536)
0.2 1.2 GO:0005663 DNA replication factor C complex(GO:0005663)
0.1 1.4 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 0.5 GO:0014802 terminal cisterna(GO:0014802)
0.1 0.8 GO:0005859 muscle myosin complex(GO:0005859)
0.1 1.2 GO:0031595 nuclear proteasome complex(GO:0031595)
0.1 4.8 GO:0034707 chloride channel complex(GO:0034707)
0.1 0.6 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.1 2.0 GO:0031528 microvillus membrane(GO:0031528)
0.1 0.8 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 0.6 GO:0001939 female pronucleus(GO:0001939)
0.1 1.9 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.4 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0 0.7 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.1 GO:0044753 amphisome(GO:0044753)
0.0 0.2 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.8 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 0.4 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 0.3 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.4 GO:0097225 sperm midpiece(GO:0097225)
0.0 1.7 GO:0031526 brush border membrane(GO:0031526)
0.0 0.6 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 2.5 GO:0005814 centriole(GO:0005814)
0.0 0.4 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 1.6 GO:0036126 sperm flagellum(GO:0036126)
0.0 0.3 GO:0032039 integrator complex(GO:0032039)
0.0 0.5 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 3.8 GO:0036464 cytoplasmic ribonucleoprotein granule(GO:0036464)
0.0 1.2 GO:0005581 collagen trimer(GO:0005581)
0.0 1.1 GO:0030118 clathrin coat(GO:0030118)
0.0 1.0 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 1.0 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.7 GO:0030315 T-tubule(GO:0030315)
0.0 0.2 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.4 GO:0014704 intercalated disc(GO:0014704)
0.0 0.6 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 2.8 GO:0043209 myelin sheath(GO:0043209)
0.0 0.7 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.4 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
1.1 5.3 GO:0035240 dopamine binding(GO:0035240)
1.0 3.9 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.7 2.9 GO:0004111 creatine kinase activity(GO:0004111)
0.7 2.0 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.4 2.6 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.4 1.5 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.3 1.3 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.3 1.9 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.3 3.2 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.2 0.7 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.2 1.1 GO:0004594 pantothenate kinase activity(GO:0004594)
0.2 0.6 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.2 0.6 GO:0005124 scavenger receptor binding(GO:0005124)
0.2 0.8 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.2 0.9 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.2 3.2 GO:0035497 cAMP response element binding(GO:0035497)
0.2 1.2 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.2 0.8 GO:1904288 BAT3 complex binding(GO:1904288)
0.2 3.0 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.2 0.8 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 1.3 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.1 0.4 GO:0003953 NAD+ nucleosidase activity(GO:0003953)
0.1 1.0 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.1 1.7 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.1 0.6 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.1 1.2 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 0.6 GO:0051525 NFAT protein binding(GO:0051525)
0.1 0.7 GO:0031432 titin binding(GO:0031432)
0.1 0.3 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.1 0.6 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.1 1.7 GO:0034185 apolipoprotein binding(GO:0034185)
0.1 0.7 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 0.2 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.1 1.9 GO:0017046 peptide hormone binding(GO:0017046)
0.1 0.4 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 3.8 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.0 0.5 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.0 0.5 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 1.2 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.1 GO:0034211 GTP-dependent protein kinase activity(GO:0034211)
0.0 1.2 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 0.3 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 1.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.6 GO:0070402 NADPH binding(GO:0070402)
0.0 0.3 GO:0004445 inositol-polyphosphate 5-phosphatase activity(GO:0004445) inositol trisphosphate phosphatase activity(GO:0046030)
0.0 0.4 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.0 1.4 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.0 0.8 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.2 GO:0001055 RNA polymerase II activity(GO:0001055)
0.0 1.7 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 0.6 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 1.6 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.4 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.7 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.6 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.2 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.0 1.5 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.1 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.0 0.4 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.3 GO:0001223 transcription coactivator binding(GO:0001223)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.2 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.2 6.2 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 3.2 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 1.9 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.8 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.0 1.2 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.9 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.0 0.7 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.9 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.3 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 1.2 PID_ATR_PATHWAY ATR signaling pathway
0.0 1.3 PID_FOXO_PATHWAY FoxO family signaling
0.0 1.2 NABA_COLLAGENS Genes encoding collagen proteins
0.0 5.1 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 0.8 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.5 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.6 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.2 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 0.4 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 0.7 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 5.3 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.2 3.7 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 1.5 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 3.8 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.1 1.3 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 1.3 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 2.1 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 1.1 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 1.8 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 1.9 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 0.9 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 0.7 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 1.9 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 3.1 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.4 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 2.1 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.6 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.2 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 1.9 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.4 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 1.2 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.9 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.2 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 1.9 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.0 2.2 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.3 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 1.0 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.3 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.2 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.2 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_RAS Genes involved in CREB phosphorylation through the activation of Ras