Motif ID: Hoxd8

Z-value: 0.530


Transcription factors associated with Hoxd8:

Gene SymbolEntrez IDGene Name
Hoxd8 ENSMUSG00000027102.4 Hoxd8



Activity profile for motif Hoxd8.

activity profile for motif Hoxd8


Sorted Z-values histogram for motif Hoxd8

Sorted Z-values for motif Hoxd8



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxd8

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_138848576 1.749 ENSMUST00000112030.2
Lhx9
LIM homeobox protein 9
chr6_+_34384218 1.198 ENSMUST00000038383.7
ENSMUST00000115051.1
Akr1b10

aldo-keto reductase family 1, member B10 (aldose reductase)

chr10_+_97482350 1.041 ENSMUST00000163448.2
Dcn
decorin
chr3_+_94372794 1.040 ENSMUST00000029795.3
Rorc
RAR-related orphan receptor gamma
chr17_-_48432723 1.035 ENSMUST00000046549.3
Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr3_+_127633134 0.978 ENSMUST00000029587.7
Neurog2
neurogenin 2
chr2_-_140671462 0.975 ENSMUST00000110057.2
Flrt3
fibronectin leucine rich transmembrane protein 3
chr2_-_140671400 0.880 ENSMUST00000056760.3
Flrt3
fibronectin leucine rich transmembrane protein 3
chr1_-_172027269 0.753 ENSMUST00000027837.6
ENSMUST00000111264.1
Vangl2

vang-like 2 (van gogh, Drosophila)

chr11_+_117809687 0.707 ENSMUST00000120928.1
ENSMUST00000175737.1
Syngr2

synaptogyrin 2

chr6_+_71282280 0.665 ENSMUST00000080949.7
Krcc1
lysine-rich coiled-coil 1
chr2_-_160619971 0.575 ENSMUST00000109473.1
Gm14221
predicted gene 14221
chr15_-_35155750 0.572 ENSMUST00000067033.7
ENSMUST00000018476.7
Stk3

serine/threonine kinase 3

chr12_-_84617326 0.556 ENSMUST00000021666.4
Abcd4
ATP-binding cassette, sub-family D (ALD), member 4
chr18_+_11633276 0.548 ENSMUST00000115861.2
Rbbp8
retinoblastoma binding protein 8
chr11_+_117809653 0.524 ENSMUST00000026649.7
ENSMUST00000177131.1
ENSMUST00000132298.1
Syngr2

Gm20708
synaptogyrin 2

predicted gene 20708
chr1_-_158814469 0.492 ENSMUST00000161589.2
Pappa2
pappalysin 2
chr19_+_24875679 0.444 ENSMUST00000073080.5
Gm10053
predicted gene 10053
chr9_+_54538984 0.434 ENSMUST00000060242.5
ENSMUST00000118413.1
Sh2d7

SH2 domain containing 7

chr10_-_127030813 0.412 ENSMUST00000040560.4
Tsfm
Ts translation elongation factor, mitochondrial
chr8_-_84662841 0.403 ENSMUST00000060427.4
Ier2
immediate early response 2
chr3_+_76075583 0.402 ENSMUST00000160261.1
Fstl5
follistatin-like 5
chr1_+_178798438 0.393 ENSMUST00000160789.1
Kif26b
kinesin family member 26B
chr3_+_24333046 0.354 ENSMUST00000077389.6
Gm7536
predicted gene 7536
chr9_-_55512156 0.346 ENSMUST00000034866.8
Etfa
electron transferring flavoprotein, alpha polypeptide
chr13_-_85127514 0.339 ENSMUST00000179230.1
Gm4076
predicted gene 4076
chr5_-_111761697 0.339 ENSMUST00000129146.1
ENSMUST00000137398.1
ENSMUST00000129065.1
E130006D01Rik


RIKEN cDNA E130006D01 gene


chr14_+_47298260 0.338 ENSMUST00000166743.1
Mapk1ip1l
mitogen-activated protein kinase 1 interacting protein 1-like
chr2_-_163472561 0.319 ENSMUST00000109418.1
Fitm2
fat storage-inducing transmembrane protein 2
chr5_-_38491948 0.312 ENSMUST00000129099.1
Slc2a9
solute carrier family 2 (facilitated glucose transporter), member 9
chr14_+_58893465 0.303 ENSMUST00000079960.1
Rpl13-ps3
ribosomal protein L13, pseudogene 3
chr5_+_92809372 0.298 ENSMUST00000113054.2
Shroom3
shroom family member 3
chr8_-_106573461 0.295 ENSMUST00000073722.5
Gm10073
predicted pseudogene 10073
chr5_-_62766153 0.287 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr7_+_126976338 0.283 ENSMUST00000032920.3
Cdipt
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)
chr5_+_48372363 0.280 ENSMUST00000030968.2
Pacrgl
PARK2 co-regulated-like
chr2_+_152687137 0.279 ENSMUST00000062148.6
Mcts2
malignant T cell amplified sequence 2
chr9_+_80165013 0.251 ENSMUST00000035889.8
ENSMUST00000113268.1
Myo6

myosin VI

chr6_+_134640940 0.246 ENSMUST00000062755.8
Loh12cr1
loss of heterozygosity, 12, chromosomal region 1 homolog (human)
chr3_-_116712644 0.234 ENSMUST00000029569.2
Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr3_-_95871367 0.232 ENSMUST00000142437.1
ENSMUST00000067298.4
Mrps21

mitochondrial ribosomal protein S21

chr3_-_19265007 0.230 ENSMUST00000091314.4
Pde7a
phosphodiesterase 7A
chrM_+_7759 0.226 ENSMUST00000082407.1
ENSMUST00000082408.1
mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr18_+_60774675 0.225 ENSMUST00000118551.1
Rps14
ribosomal protein S14
chr12_-_87444017 0.225 ENSMUST00000091090.4
2700073G19Rik
RIKEN cDNA 2700073G19 gene
chr3_+_106034661 0.219 ENSMUST00000170669.2
Gm4540
predicted gene 4540
chr8_+_33599608 0.219 ENSMUST00000009774.9
Ppp2cb
protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
chr3_+_88716838 0.216 ENSMUST00000029692.8
ENSMUST00000171645.1
Rit1

Ras-like without CAAX 1

chr2_+_152669461 0.214 ENSMUST00000125366.1
ENSMUST00000109825.1
ENSMUST00000089059.2
ENSMUST00000079247.3
H13



histocompatibility 13



chr4_+_118961578 0.212 ENSMUST00000058651.4
Lao1
L-amino acid oxidase 1
chr17_+_74489492 0.210 ENSMUST00000024873.6
Yipf4
Yip1 domain family, member 4
chr4_-_132398199 0.208 ENSMUST00000136711.1
ENSMUST00000084249.4
Phactr4

phosphatase and actin regulator 4

chr9_+_72806874 0.208 ENSMUST00000055535.8
Prtg
protogenin homolog (Gallus gallus)
chr10_-_127030789 0.205 ENSMUST00000120547.1
ENSMUST00000152054.1
Tsfm

Ts translation elongation factor, mitochondrial

chr9_-_57158288 0.201 ENSMUST00000065358.7
Commd4
COMM domain containing 4
chr1_-_127840290 0.175 ENSMUST00000061512.2
Map3k19
mitogen-activated protein kinase kinase kinase 19
chr17_-_26099257 0.174 ENSMUST00000053575.3
Gm8186
predicted gene 8186
chr9_+_75051977 0.173 ENSMUST00000170310.1
ENSMUST00000166549.1
Arpp19

cAMP-regulated phosphoprotein 19

chr3_-_96197580 0.164 ENSMUST00000016087.3
Bola1
bolA-like 1 (E. coli)
chr3_+_88716884 0.161 ENSMUST00000172252.1
Rit1
Ras-like without CAAX 1
chr3_-_19264959 0.159 ENSMUST00000121951.1
Pde7a
phosphodiesterase 7A
chr9_+_80165079 0.159 ENSMUST00000184480.1
Myo6
myosin VI
chr1_+_178405881 0.157 ENSMUST00000027775.7
Efcab2
EF-hand calcium binding domain 2
chr12_+_87443896 0.154 ENSMUST00000161023.1
ENSMUST00000160488.1
ENSMUST00000077462.7
ENSMUST00000160880.1
Slirp



SRA stem-loop interacting RNA binding protein



chr14_+_55559993 0.154 ENSMUST00000117236.1
Dcaf11
DDB1 and CUL4 associated factor 11
chrX_-_160138375 0.151 ENSMUST00000033662.8
Pdha1
pyruvate dehydrogenase E1 alpha 1
chr2_-_73580288 0.150 ENSMUST00000028515.3
Chrna1
cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)
chrX_+_56786527 0.149 ENSMUST00000144600.1
Fhl1
four and a half LIM domains 1
chr19_-_33761949 0.149 ENSMUST00000025694.6
ENSMUST00000147153.1
Lipo1
Lipo2
lipase, member O1
lipase, member O2
chrX_-_74393003 0.143 ENSMUST00000015427.6
Fam3a
family with sequence similarity 3, member A
chr2_+_110597298 0.141 ENSMUST00000045972.6
ENSMUST00000111026.2
Slc5a12

solute carrier family 5 (sodium/glucose cotransporter), member 12

chr2_+_83724397 0.135 ENSMUST00000028499.4
ENSMUST00000141725.1
ENSMUST00000111740.2
Itgav


integrin alpha V


chr8_+_40354303 0.115 ENSMUST00000136835.1
Micu3
mitochondrial calcium uptake family, member 3
chr12_-_12940600 0.115 ENSMUST00000130990.1
Mycn
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
chr5_-_73191848 0.103 ENSMUST00000176910.1
Fryl
furry homolog-like (Drosophila)
chr7_-_45062393 0.096 ENSMUST00000129101.1
Prrg2
proline-rich Gla (G-carboxyglutamic acid) polypeptide 2
chr17_-_56036546 0.087 ENSMUST00000003268.9
Sh3gl1
SH3-domain GRB2-like 1
chr8_-_21906412 0.085 ENSMUST00000051965.4
Defb11
defensin beta 11
chr7_+_140763739 0.081 ENSMUST00000026552.7
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
chr5_-_121527186 0.078 ENSMUST00000152270.1
Mapkapk5
MAP kinase-activated protein kinase 5
chr10_-_76110956 0.070 ENSMUST00000120757.1
Slc5a4b
solute carrier family 5 (neutral amino acid transporters, system A), member 4b
chr12_-_54695885 0.069 ENSMUST00000067272.8
Eapp
E2F-associated phosphoprotein
chr7_-_80405425 0.060 ENSMUST00000107362.3
ENSMUST00000135306.1
Furin

furin (paired basic amino acid cleaving enzyme)

chr12_-_54695829 0.053 ENSMUST00000162106.1
ENSMUST00000160085.1
ENSMUST00000161592.1
ENSMUST00000163433.1
Eapp



E2F-associated phosphoprotein



chr11_+_109543694 0.044 ENSMUST00000106696.1
Arsg
arylsulfatase G
chr10_+_58394361 0.041 ENSMUST00000020077.4
Lims1
LIM and senescent cell antigen-like domains 1
chr12_+_72536342 0.039 ENSMUST00000044352.6
Pcnxl4
pecanex-like 4 (Drosophila)
chr7_-_99980431 0.029 ENSMUST00000080817.4
Rnf169
ring finger protein 169
chr13_-_58354862 0.028 ENSMUST00000043605.5
Kif27
kinesin family member 27
chr7_+_39588931 0.026 ENSMUST00000178791.1
ENSMUST00000098511.3
Gm2058

predicted gene 2058

chr2_+_151494182 0.025 ENSMUST00000089140.6
Nsfl1c
NSFL1 (p97) cofactor (p47)
chr14_+_55560010 0.019 ENSMUST00000147981.1
ENSMUST00000133256.1
Dcaf11

DDB1 and CUL4 associated factor 11

chr18_+_56562443 0.010 ENSMUST00000130163.1
ENSMUST00000132628.1
Phax

phosphorylated adaptor for RNA export


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:0003345 proepicardium cell migration involved in pericardium morphogenesis(GO:0003345)
0.4 1.9 GO:0035262 gonad morphogenesis(GO:0035262)
0.3 1.0 GO:0016554 cytidine to uridine editing(GO:0016554)
0.3 0.8 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.2 0.6 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.1 1.0 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.1 0.6 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.1 0.4 GO:0072092 ureteric bud invasion(GO:0072092)
0.1 1.0 GO:0072615 interleukin-17 secretion(GO:0072615)
0.1 0.5 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.1 0.3 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.1 0.6 GO:0009235 cobalamin metabolic process(GO:0009235)
0.1 0.3 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.1 0.2 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.1 0.3 GO:0002188 translation reinitiation(GO:0002188)
0.1 0.2 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.0 0.1 GO:1905034 regulation of antifungal innate immune response(GO:1905034) negative regulation of antifungal innate immune response(GO:1905035)
0.0 0.2 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.0 0.3 GO:0046415 urate metabolic process(GO:0046415)
0.0 0.2 GO:0000957 mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
0.0 0.4 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.0 0.2 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.0 0.2 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0 0.3 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0 0.1 GO:0090472 dibasic protein processing(GO:0090472)
0.0 0.1 GO:1904659 glucose transmembrane transport(GO:1904659)
0.0 0.1 GO:0045607 regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.0 0.1 GO:0090527 actin filament reorganization(GO:0090527)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0060187 cell pole(GO:0060187)
0.1 0.3 GO:0045251 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.1 1.0 GO:0098644 complex of collagen trimers(GO:0098644)
0.0 0.1 GO:0034684 integrin alphav-beta5 complex(GO:0034684)
0.0 0.2 GO:0071556 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.0 1.9 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.2 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 1.2 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 0.2 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.4 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0008142 oxysterol binding(GO:0008142)
0.3 1.0 GO:0004126 cytidine deaminase activity(GO:0004126)
0.2 1.2 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.1 1.9 GO:0045499 chemorepellent activity(GO:0045499)
0.1 0.3 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.1 0.2 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.0 0.2 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.0 0.5 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 0.3 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0 0.2 GO:0034604 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.0 0.1 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.1 GO:0019960 C-X3-C chemokine binding(GO:0019960) neuregulin binding(GO:0038132)
0.0 0.2 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.6 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 1.0 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.2 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.1 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 1.0 GO:0070888 E-box binding(GO:0070888)
0.0 0.3 GO:0005402 cation:sugar symporter activity(GO:0005402)
0.0 0.4 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.5 PID_BARD1_PATHWAY BARD1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 0.5 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.3 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.4 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.0 0.2 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.0 0.6 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 0.4 REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 0.2 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex