Motif ID: En2
Z-value: 0.575

Transcription factors associated with En2:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
En2 | ENSMUSG00000039095.7 | En2 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
En2 | mm10_v2_chr5_+_28165690_28165717 | -0.56 | 1.2e-04 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.1 | 3.4 | GO:0090274 | positive regulation of somatostatin secretion(GO:0090274) |
0.6 | 4.6 | GO:0035726 | common myeloid progenitor cell proliferation(GO:0035726) |
0.5 | 2.3 | GO:0006564 | L-serine biosynthetic process(GO:0006564) |
0.4 | 1.2 | GO:0060023 | soft palate development(GO:0060023) |
0.4 | 1.1 | GO:0061357 | Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) positive regulation of Wnt protein secretion(GO:0061357) |
0.3 | 1.4 | GO:0061743 | motor learning(GO:0061743) |
0.3 | 1.3 | GO:0051866 | general adaptation syndrome(GO:0051866) |
0.3 | 2.2 | GO:0019532 | oxalate transport(GO:0019532) |
0.3 | 5.2 | GO:0030953 | astral microtubule organization(GO:0030953) |
0.3 | 2.5 | GO:0051798 | positive regulation of hair follicle development(GO:0051798) |
0.3 | 1.4 | GO:2001032 | regulation of double-strand break repair via nonhomologous end joining(GO:2001032) |
0.3 | 0.8 | GO:2000393 | negative regulation of lamellipodium morphogenesis(GO:2000393) |
0.2 | 0.7 | GO:0045113 | regulation of integrin biosynthetic process(GO:0045113) |
0.2 | 0.8 | GO:0001550 | ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) |
0.2 | 2.2 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
0.2 | 1.2 | GO:0043415 | positive regulation of skeletal muscle tissue regeneration(GO:0043415) |
0.2 | 4.0 | GO:0007530 | sex determination(GO:0007530) |
0.2 | 3.3 | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore(GO:0051988) |
0.2 | 0.5 | GO:0007290 | spermatid nucleus elongation(GO:0007290) |
0.2 | 0.5 | GO:1904879 | positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879) |
0.1 | 4.4 | GO:0034723 | DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723) |
0.1 | 0.6 | GO:0036091 | positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091) |
0.1 | 0.9 | GO:0031547 | brain-derived neurotrophic factor receptor signaling pathway(GO:0031547) |
0.1 | 1.0 | GO:0046645 | positive regulation of gamma-delta T cell differentiation(GO:0045588) positive regulation of gamma-delta T cell activation(GO:0046645) positive regulation of uterine smooth muscle contraction(GO:0070474) |
0.1 | 2.3 | GO:0000920 | cell separation after cytokinesis(GO:0000920) |
0.1 | 1.0 | GO:0050957 | equilibrioception(GO:0050957) |
0.1 | 1.7 | GO:0021891 | olfactory bulb interneuron development(GO:0021891) |
0.1 | 0.7 | GO:0016198 | axon choice point recognition(GO:0016198) |
0.1 | 0.3 | GO:0030327 | prenylated protein catabolic process(GO:0030327) |
0.1 | 0.5 | GO:0090324 | negative regulation of oxidative phosphorylation(GO:0090324) |
0.1 | 0.6 | GO:0045218 | zonula adherens maintenance(GO:0045218) |
0.1 | 0.2 | GO:0002669 | positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913) |
0.1 | 0.3 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
0.1 | 1.2 | GO:0021796 | cerebral cortex regionalization(GO:0021796) |
0.1 | 0.6 | GO:0005513 | detection of calcium ion(GO:0005513) |
0.1 | 0.3 | GO:0007021 | tubulin complex assembly(GO:0007021) |
0.1 | 0.7 | GO:0034219 | carbohydrate transmembrane transport(GO:0034219) |
0.1 | 0.2 | GO:0061055 | myotome development(GO:0061055) |
0.1 | 0.1 | GO:0002725 | negative regulation of T cell cytokine production(GO:0002725) |
0.0 | 1.3 | GO:0008340 | determination of adult lifespan(GO:0008340) |
0.0 | 0.6 | GO:1903504 | regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504) |
0.0 | 0.6 | GO:0060307 | regulation of ventricular cardiac muscle cell membrane repolarization(GO:0060307) |
0.0 | 0.5 | GO:0001973 | adenosine receptor signaling pathway(GO:0001973) |
0.0 | 0.2 | GO:0030916 | otic vesicle formation(GO:0030916) |
0.0 | 0.1 | GO:0060155 | platelet dense granule organization(GO:0060155) |
0.0 | 0.1 | GO:0030300 | regulation of intestinal cholesterol absorption(GO:0030300) |
0.0 | 1.1 | GO:0034508 | centromere complex assembly(GO:0034508) |
0.0 | 1.1 | GO:0007131 | reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825) |
0.0 | 0.7 | GO:0045672 | positive regulation of osteoclast differentiation(GO:0045672) |
0.0 | 1.8 | GO:0035307 | positive regulation of protein dephosphorylation(GO:0035307) |
0.0 | 0.2 | GO:0071361 | cellular response to ethanol(GO:0071361) |
0.0 | 0.2 | GO:0046337 | phosphatidylethanolamine metabolic process(GO:0046337) |
0.0 | 0.6 | GO:0051894 | positive regulation of focal adhesion assembly(GO:0051894) |
0.0 | 0.8 | GO:0009409 | response to cold(GO:0009409) |
0.0 | 1.5 | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) |
0.0 | 1.8 | GO:0006334 | nucleosome assembly(GO:0006334) |
0.0 | 0.1 | GO:0015791 | polyol transport(GO:0015791) bile acid secretion(GO:0032782) |
0.0 | 0.0 | GO:0075136 | response to defenses of other organism involved in symbiotic interaction(GO:0052173) response to host defenses(GO:0052200) response to host(GO:0075136) |
0.0 | 0.3 | GO:0016226 | iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163) |
0.0 | 0.2 | GO:2000114 | regulation of establishment of cell polarity(GO:2000114) |
0.0 | 0.1 | GO:0050860 | negative regulation of T cell receptor signaling pathway(GO:0050860) |
0.0 | 0.1 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
0.0 | 0.0 | GO:1902220 | positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902220) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.7 | 3.3 | GO:0097149 | centralspindlin complex(GO:0097149) |
0.2 | 0.7 | GO:0071438 | invadopodium membrane(GO:0071438) |
0.1 | 0.6 | GO:1990590 | ATF1-ATF4 transcription factor complex(GO:1990590) |
0.1 | 1.1 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
0.1 | 0.5 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
0.1 | 0.3 | GO:0032807 | DNA ligase IV complex(GO:0032807) |
0.1 | 1.8 | GO:0000788 | nuclear nucleosome(GO:0000788) |
0.1 | 0.6 | GO:0005915 | zonula adherens(GO:0005915) |
0.0 | 0.1 | GO:0045009 | melanosome membrane(GO:0033162) chitosome(GO:0045009) |
0.0 | 0.5 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
0.0 | 1.2 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
0.0 | 1.0 | GO:0000242 | pericentriolar material(GO:0000242) |
0.0 | 0.6 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
0.0 | 0.2 | GO:0071437 | invadopodium(GO:0071437) |
0.0 | 0.4 | GO:0043189 | NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562) |
0.0 | 2.3 | GO:0005871 | kinesin complex(GO:0005871) |
0.0 | 1.3 | GO:0000786 | nucleosome(GO:0000786) |
0.0 | 0.7 | GO:0031527 | filopodium membrane(GO:0031527) |
0.0 | 1.1 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
0.0 | 4.0 | GO:0043195 | terminal bouton(GO:0043195) |
0.0 | 0.3 | GO:0016272 | prefoldin complex(GO:0016272) |
0.0 | 1.0 | GO:0032420 | stereocilium(GO:0032420) |
0.0 | 0.1 | GO:1990357 | terminal web(GO:1990357) |
0.0 | 0.3 | GO:0044322 | endoplasmic reticulum quality control compartment(GO:0044322) |
0.0 | 0.2 | GO:0045252 | oxoglutarate dehydrogenase complex(GO:0045252) |
0.0 | 0.3 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
0.0 | 0.3 | GO:0031616 | spindle pole centrosome(GO:0031616) |
0.0 | 1.3 | GO:0005581 | collagen trimer(GO:0005581) |
0.0 | 0.3 | GO:0033276 | transcription factor TFTC complex(GO:0033276) |
0.0 | 0.5 | GO:0001772 | immunological synapse(GO:0001772) |
0.0 | 0.3 | GO:0005797 | Golgi medial cisterna(GO:0005797) |
0.0 | 0.6 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
0.0 | 0.3 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 0.7 | GO:0030171 | voltage-gated proton channel activity(GO:0030171) |
0.2 | 2.5 | GO:0048185 | activin binding(GO:0048185) |
0.2 | 1.0 | GO:0042610 | CD8 receptor binding(GO:0042610) |
0.2 | 2.2 | GO:0019531 | secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531) |
0.1 | 0.6 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
0.1 | 0.8 | GO:0005025 | transforming growth factor beta receptor activity, type I(GO:0005025) |
0.1 | 2.3 | GO:0008483 | transaminase activity(GO:0008483) |
0.1 | 1.1 | GO:0031852 | mu-type opioid receptor binding(GO:0031852) |
0.1 | 0.4 | GO:0003681 | bent DNA binding(GO:0003681) |
0.1 | 0.7 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) |
0.1 | 3.6 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
0.1 | 0.5 | GO:0086056 | voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056) |
0.1 | 0.6 | GO:0086006 | voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006) |
0.1 | 0.3 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
0.1 | 1.1 | GO:0050692 | DBD domain binding(GO:0050692) |
0.1 | 3.1 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
0.1 | 0.2 | GO:0005220 | inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220) |
0.1 | 0.5 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
0.1 | 0.4 | GO:0004984 | olfactory receptor activity(GO:0004984) |
0.1 | 0.2 | GO:0003998 | acylphosphatase activity(GO:0003998) |
0.0 | 0.9 | GO:0010485 | H4 histone acetyltransferase activity(GO:0010485) |
0.0 | 0.1 | GO:0035651 | AP-1 adaptor complex binding(GO:0035650) AP-3 adaptor complex binding(GO:0035651) |
0.0 | 0.6 | GO:0070097 | delta-catenin binding(GO:0070097) |
0.0 | 0.6 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
0.0 | 2.5 | GO:0008528 | G-protein coupled peptide receptor activity(GO:0008528) |
0.0 | 0.3 | GO:0016670 | oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670) |
0.0 | 1.1 | GO:0097602 | cullin family protein binding(GO:0097602) |
0.0 | 1.3 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
0.0 | 0.1 | GO:0015254 | glycerol channel activity(GO:0015254) |
0.0 | 0.7 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
0.0 | 1.2 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
0.0 | 0.7 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
0.0 | 0.1 | GO:0004104 | choline kinase activity(GO:0004103) cholinesterase activity(GO:0004104) choline binding(GO:0033265) |
0.0 | 0.2 | GO:0004591 | oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591) |
0.0 | 2.3 | GO:0003777 | microtubule motor activity(GO:0003777) |
0.0 | 0.5 | GO:0031683 | G-protein beta/gamma-subunit complex binding(GO:0031683) |
0.0 | 0.5 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) |
0.0 | 0.3 | GO:0005522 | profilin binding(GO:0005522) |
0.0 | 1.2 | GO:0015485 | cholesterol binding(GO:0015485) |
0.0 | 1.3 | GO:0003774 | motor activity(GO:0003774) |
0.0 | 0.8 | GO:0008013 | beta-catenin binding(GO:0008013) |
0.0 | 2.4 | GO:0017048 | Rho GTPase binding(GO:0017048) |
0.0 | 0.3 | GO:0046977 | TAP binding(GO:0046977) |
0.0 | 0.3 | GO:0003688 | DNA replication origin binding(GO:0003688) |
0.0 | 0.7 | GO:0015144 | carbohydrate transmembrane transporter activity(GO:0015144) carbohydrate transporter activity(GO:1901476) |
0.0 | 0.1 | GO:0016453 | acetyl-CoA C-acetyltransferase activity(GO:0003985) C-acetyltransferase activity(GO:0016453) |
0.0 | 0.3 | GO:1904264 | ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264) |
0.0 | 0.1 | GO:0039706 | co-receptor binding(GO:0039706) |
0.0 | 5.4 | GO:0000987 | core promoter proximal region sequence-specific DNA binding(GO:0000987) |
0.0 | 0.3 | GO:0043566 | structure-specific DNA binding(GO:0043566) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 3.5 | PID_AURORA_A_PATHWAY | Aurora A signaling |
0.1 | 5.2 | PID_PLK1_PATHWAY | PLK1 signaling events |
0.1 | 3.4 | PID_BMP_PATHWAY | BMP receptor signaling |
0.1 | 2.6 | PID_EPHRINB_REV_PATHWAY | Ephrin B reverse signaling |
0.1 | 2.2 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
0.0 | 0.5 | PID_S1P_S1P4_PATHWAY | S1P4 pathway |
0.0 | 1.5 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
0.0 | 1.2 | NABA_COLLAGENS | Genes encoding collagen proteins |
0.0 | 3.0 | PID_MYC_ACTIV_PATHWAY | Validated targets of C-MYC transcriptional activation |
0.0 | 0.3 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
0.0 | 0.7 | PID_NCADHERIN_PATHWAY | N-cadherin signaling events |
0.0 | 0.6 | SIG_CD40PATHWAYMAP | Genes related to CD40 signaling |
0.0 | 0.9 | ST_ERK1_ERK2_MAPK_PATHWAY | ERK1/ERK2 MAPK Pathway |
0.0 | 0.3 | PID_DNA_PK_PATHWAY | DNA-PK pathway in nonhomologous end joining |
0.0 | 0.4 | PID_FGF_PATHWAY | FGF signaling pathway |
0.0 | 0.4 | PID_ILK_PATHWAY | Integrin-linked kinase signaling |
0.0 | 0.3 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
0.0 | 0.2 | PID_CD40_PATHWAY | CD40/CD40L signaling |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 1.0 | REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
0.1 | 2.3 | REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
0.1 | 2.3 | REACTOME_KINESINS | Genes involved in Kinesins |
0.1 | 0.6 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
0.1 | 3.1 | REACTOME_RNA_POL_I_PROMOTER_OPENING | Genes involved in RNA Polymerase I Promoter Opening |
0.1 | 0.6 | REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
0.1 | 0.7 | REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION | Genes involved in FGFR1 ligand binding and activation |
0.0 | 1.1 | REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
0.0 | 0.5 | REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY | Genes involved in Adenylate cyclase inhibitory pathway |
0.0 | 0.2 | REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |
0.0 | 2.5 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
0.0 | 0.8 | REACTOME_SIGNALING_BY_BMP | Genes involved in Signaling by BMP |
0.0 | 2.0 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
0.0 | 0.5 | REACTOME_REGULATION_OF_KIT_SIGNALING | Genes involved in Regulation of KIT signaling |
0.0 | 0.3 | REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES | Genes involved in Generation of second messenger molecules |
0.0 | 0.5 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
0.0 | 1.2 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
0.0 | 1.3 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
0.0 | 0.1 | REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
0.0 | 0.5 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
0.0 | 0.5 | REACTOME_GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
0.0 | 0.2 | REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |