Motif ID: Hoxb3

Z-value: 1.283


Transcription factors associated with Hoxb3:

Gene SymbolEntrez IDGene Name
Hoxb3 ENSMUSG00000048763.5 Hoxb3



Activity profile for motif Hoxb3.

activity profile for motif Hoxb3


Sorted Z-values histogram for motif Hoxb3

Sorted Z-values for motif Hoxb3



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_8710734 14.972 ENSMUST00000005493.7
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr15_-_8710409 12.090 ENSMUST00000157065.1
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr9_-_54661870 11.261 ENSMUST00000034822.5
Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr9_-_54661666 7.982 ENSMUST00000128624.1
Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr3_-_85722474 6.849 ENSMUST00000119077.1
Fam160a1
family with sequence similarity 160, member A1
chrX_+_170009892 6.630 ENSMUST00000180251.1
Gm21887
predicted gene, 21887
chrY_+_90785442 6.091 ENSMUST00000177591.1
ENSMUST00000177671.1
ENSMUST00000179077.1
Erdr1


erythroid differentiation regulator 1


chr5_+_134932351 5.507 ENSMUST00000047196.7
ENSMUST00000111221.2
ENSMUST00000111219.1
ENSMUST00000068617.5
ENSMUST00000111218.1
ENSMUST00000136246.1
Wbscr27





Williams Beuren syndrome chromosome region 27 (human)





chr2_+_116067213 5.502 ENSMUST00000152412.1
G630016G05Rik
RIKEN cDNA G630016G05 gene
chr12_+_84069325 5.290 ENSMUST00000046422.4
ENSMUST00000072505.4
Acot5

acyl-CoA thioesterase 5

chr4_-_14621805 5.243 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chr19_+_3323301 5.122 ENSMUST00000025835.4
Cpt1a
carnitine palmitoyltransferase 1a, liver
chr2_+_91257323 4.986 ENSMUST00000111349.2
ENSMUST00000131711.1
Pacsin3

protein kinase C and casein kinase substrate in neurons 3

chr11_+_101665541 4.833 ENSMUST00000039388.2
Arl4d
ADP-ribosylation factor-like 4D
chr12_+_74288735 4.498 ENSMUST00000095617.1
1700086L19Rik
RIKEN cDNA 1700086L19 gene
chr13_+_94083490 4.292 ENSMUST00000156071.1
Lhfpl2
lipoma HMGIC fusion partner-like 2
chrY_+_90784738 3.995 ENSMUST00000179483.1
Erdr1
erythroid differentiation regulator 1
chrX_+_100729917 3.562 ENSMUST00000019503.7
Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chr14_-_64455903 3.484 ENSMUST00000067927.7
Msra
methionine sulfoxide reductase A
chr2_-_116067391 3.272 ENSMUST00000140185.1
2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr5_+_140607334 3.176 ENSMUST00000031555.1
Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr8_+_23411490 3.076 ENSMUST00000033952.7
Sfrp1
secreted frizzled-related protein 1
chrX_+_170010744 2.944 ENSMUST00000178789.1
Gm21887
predicted gene, 21887
chr3_-_121263314 2.793 ENSMUST00000029777.7
Tmem56
transmembrane protein 56
chr5_-_77115145 2.653 ENSMUST00000081964.5
Hopx
HOP homeobox
chr10_-_83648631 2.540 ENSMUST00000146876.2
ENSMUST00000176294.1
Appl2

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2

chr12_-_25096080 2.452 ENSMUST00000020974.6
Id2
inhibitor of DNA binding 2
chr7_-_45092130 2.438 ENSMUST00000148175.1
Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr7_-_45092198 2.435 ENSMUST00000140449.1
ENSMUST00000117546.1
ENSMUST00000019683.3
Rcn3


reticulocalbin 3, EF-hand calcium binding domain


chr14_+_26259109 2.419 ENSMUST00000174494.1
Duxbl3
double homeobox B-like 3
chr9_-_120068263 2.269 ENSMUST00000064165.3
ENSMUST00000177637.1
Cx3cr1

chemokine (C-X3-C) receptor 1

chr7_-_45091713 2.245 ENSMUST00000141576.1
Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr5_+_103425181 2.184 ENSMUST00000048957.9
Ptpn13
protein tyrosine phosphatase, non-receptor type 13
chr4_-_14621494 2.007 ENSMUST00000149633.1
Slc26a7
solute carrier family 26, member 7
chr17_-_47834682 1.991 ENSMUST00000066368.6
Mdfi
MyoD family inhibitor
chr14_+_99298652 1.936 ENSMUST00000005279.6
Klf5
Kruppel-like factor 5
chr11_+_32283511 1.822 ENSMUST00000093209.3
Hba-a1
hemoglobin alpha, adult chain 1
chr2_+_119047129 1.819 ENSMUST00000153300.1
ENSMUST00000028799.5
Casc5

cancer susceptibility candidate 5

chr5_+_63812447 1.738 ENSMUST00000081747.3
0610040J01Rik
RIKEN cDNA 0610040J01 gene
chr14_+_26119173 1.709 ENSMUST00000174564.1
Duxbl2
doubl homeobox B-like 2
chr14_+_26258786 1.709 ENSMUST00000172517.1
Duxbl3
double homeobox B-like 3
chr5_-_106926245 1.694 ENSMUST00000117588.1
Hfm1
HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)
chr12_-_98577940 1.686 ENSMUST00000110113.1
Kcnk10
potassium channel, subfamily K, member 10
chr2_+_119047116 1.679 ENSMUST00000152380.1
ENSMUST00000099542.2
Casc5

cancer susceptibility candidate 5

chr10_+_90071095 1.591 ENSMUST00000183109.1
Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr18_+_12741324 1.578 ENSMUST00000115857.2
ENSMUST00000121018.1
ENSMUST00000119108.1
Cabyr


calcium-binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)


chrX_+_107255878 1.576 ENSMUST00000101294.2
ENSMUST00000118820.1
ENSMUST00000120971.1
Gpr174


G protein-coupled receptor 174


chr3_+_65666223 1.556 ENSMUST00000099075.2
ENSMUST00000107848.1
ENSMUST00000161794.1
Lekr1


leucine, glutamate and lysine rich 1


chrX_-_9256899 1.529 ENSMUST00000115553.2
Gm14862
predicted gene 14862
chr2_+_109917639 1.475 ENSMUST00000046548.7
ENSMUST00000111037.2
Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr4_-_14621669 1.429 ENSMUST00000143105.1
Slc26a7
solute carrier family 26, member 7
chr8_+_66386292 1.428 ENSMUST00000039540.5
ENSMUST00000110253.2
March1

membrane-associated ring finger (C3HC4) 1

chr14_+_26119811 1.409 ENSMUST00000173617.1
Duxbl2
doubl homeobox B-like 2
chr7_-_5413145 1.394 ENSMUST00000108569.2
Vmn1r58
vomeronasal 1 receptor 58
chr2_+_3424123 1.393 ENSMUST00000061852.5
ENSMUST00000100463.3
ENSMUST00000102988.3
ENSMUST00000115066.1
Dclre1c



DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae)



chr12_-_98901478 1.260 ENSMUST00000065716.6
Eml5
echinoderm microtubule associated protein like 5
chr9_-_96719404 1.220 ENSMUST00000140121.1
Zbtb38
zinc finger and BTB domain containing 38
chr14_+_62292475 1.207 ENSMUST00000166879.1
Rnaseh2b
ribonuclease H2, subunit B
chr13_+_44121167 1.172 ENSMUST00000163056.1
ENSMUST00000159595.1
Gm5083

predicted gene 5083

chr5_-_84417359 1.150 ENSMUST00000113401.1
Epha5
Eph receptor A5
chr5_+_136987019 1.121 ENSMUST00000004968.4
Plod3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr9_-_96719549 1.109 ENSMUST00000128269.1
Zbtb38
zinc finger and BTB domain containing 38
chr14_+_25980039 1.099 ENSMUST00000173155.1
Duxbl1
double homeobox B-like 1
chr7_-_67222412 1.095 ENSMUST00000181631.1
1700112J16Rik
RIKEN cDNA 1700112J16 gene
chr13_-_92483996 1.084 ENSMUST00000040106.7
Fam151b
family with sequence similarity 151, member B
chr11_+_116843278 1.017 ENSMUST00000106370.3
Mettl23
methyltransferase like 23
chr14_+_25979401 1.015 ENSMUST00000173580.1
Duxbl1
double homeobox B-like 1
chr10_+_40349265 1.012 ENSMUST00000044672.4
ENSMUST00000095743.2
Cdk19

cyclin-dependent kinase 19

chr2_-_161109017 0.985 ENSMUST00000039782.7
ENSMUST00000134178.1
Chd6

chromodomain helicase DNA binding protein 6

chr8_+_40354303 0.899 ENSMUST00000136835.1
Micu3
mitochondrial calcium uptake family, member 3
chr18_+_49832622 0.858 ENSMUST00000180611.1
Dmxl1
Dmx-like 1
chr5_-_137786681 0.854 ENSMUST00000132726.1
Mepce
methylphosphate capping enzyme
chr4_+_102570065 0.746 ENSMUST00000097950.2
Pde4b
phosphodiesterase 4B, cAMP specific
chr2_+_71389239 0.733 ENSMUST00000028408.2
Hat1
histone aminotransferase 1
chr10_-_128525859 0.722 ENSMUST00000026427.6
Esyt1
extended synaptotagmin-like protein 1
chr4_-_41045381 0.700 ENSMUST00000054945.7
Aqp7
aquaporin 7
chr2_-_45112890 0.684 ENSMUST00000076836.6
Zeb2
zinc finger E-box binding homeobox 2
chr12_-_83487708 0.682 ENSMUST00000177959.1
ENSMUST00000178756.1
Dpf3

D4, zinc and double PHD fingers, family 3

chr4_-_155645408 0.660 ENSMUST00000115821.2
Gm10563
predicted gene 10563
chr10_-_125328957 0.651 ENSMUST00000063318.2
Slc16a7
solute carrier family 16 (monocarboxylic acid transporters), member 7
chr6_+_113333304 0.630 ENSMUST00000147945.1
Ogg1
8-oxoguanine DNA-glycosylase 1
chr13_-_74807913 0.625 ENSMUST00000065629.4
Cast
calpastatin
chr9_+_119341487 0.599 ENSMUST00000175743.1
ENSMUST00000176397.1
Acaa1a

acetyl-Coenzyme A acyltransferase 1A

chr5_-_138170992 0.577 ENSMUST00000139983.1
Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
chr2_-_20943413 0.559 ENSMUST00000140230.1
Arhgap21
Rho GTPase activating protein 21
chr13_-_67332525 0.557 ENSMUST00000168892.1
ENSMUST00000109735.2
Zfp595

zinc finger protein 595

chr12_+_84285232 0.529 ENSMUST00000123614.1
ENSMUST00000147363.1
ENSMUST00000135001.1
ENSMUST00000146377.1
Ptgr2



prostaglandin reductase 2



chr12_+_21417872 0.528 ENSMUST00000180671.1
Gm4419
predicted gene 4419
chr7_+_67222544 0.506 ENSMUST00000058771.5
ENSMUST00000179106.1
Lysmd4

LysM, putative peptidoglycan-binding, domain containing 4

chr3_-_34351685 0.411 ENSMUST00000174114.1
Gm20514
predicted gene 20514
chr2_+_36230426 0.408 ENSMUST00000062069.5
Ptgs1
prostaglandin-endoperoxide synthase 1
chr11_+_69580359 0.383 ENSMUST00000005371.5
ENSMUST00000108658.3
ENSMUST00000171247.1
Trp53


transformation related protein 53


chr1_-_33814591 0.368 ENSMUST00000019861.6
Zfp451
zinc finger protein 451
chr11_+_103116228 0.359 ENSMUST00000053063.5
Hexim1
hexamethylene bis-acetamide inducible 1
chr5_-_137786651 0.348 ENSMUST00000031740.9
Mepce
methylphosphate capping enzyme
chr11_-_45955183 0.345 ENSMUST00000109254.1
Thg1l
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
chr8_-_109962127 0.324 ENSMUST00000001722.7
ENSMUST00000051430.6
Marveld3

MARVEL (membrane-associating) domain containing 3

chr9_-_15301555 0.318 ENSMUST00000034414.8
4931406C07Rik
RIKEN cDNA 4931406C07 gene
chr14_-_75754475 0.315 ENSMUST00000049168.7
Cog3
component of oligomeric golgi complex 3
chr18_+_37355271 0.307 ENSMUST00000051163.1
Pcdhb8
protocadherin beta 8
chr19_-_32061438 0.305 ENSMUST00000096119.4
Asah2
N-acylsphingosine amidohydrolase 2
chr19_-_32196393 0.281 ENSMUST00000151822.1
Sgms1
sphingomyelin synthase 1
chr7_+_57387304 0.267 ENSMUST00000085241.5
Gm9962
predicted gene 9962
chr9_-_85749308 0.251 ENSMUST00000039213.8
Ibtk
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr3_+_159839729 0.251 ENSMUST00000068952.5
Wls
wntless homolog (Drosophila)
chr8_-_104534630 0.247 ENSMUST00000162466.1
ENSMUST00000034349.9
Nae1

NEDD8 activating enzyme E1 subunit 1

chr7_-_114636299 0.243 ENSMUST00000032906.4
ENSMUST00000032907.7
Calca

calcitonin/calcitonin-related polypeptide, alpha

chr10_-_128589650 0.239 ENSMUST00000082059.6
Erbb3
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
chr2_-_155074447 0.217 ENSMUST00000137242.1
ENSMUST00000054607.9
Ahcy

S-adenosylhomocysteine hydrolase

chr18_+_9958147 0.216 ENSMUST00000025137.7
Thoc1
THO complex 1
chr10_-_117148474 0.216 ENSMUST00000020381.3
Frs2
fibroblast growth factor receptor substrate 2
chr12_+_16653470 0.215 ENSMUST00000111064.1
Ntsr2
neurotensin receptor 2
chr5_+_145204523 0.212 ENSMUST00000085671.3
ENSMUST00000031601.7
Zkscan5

zinc finger with KRAB and SCAN domains 5

chr10_-_76110956 0.178 ENSMUST00000120757.1
Slc5a4b
solute carrier family 5 (neutral amino acid transporters, system A), member 4b
chr18_+_24603952 0.176 ENSMUST00000025120.6
Elp2
elongator acetyltransferase complex subunit 2
chr1_-_33814516 0.169 ENSMUST00000044455.5
ENSMUST00000115167.1
Zfp451

zinc finger protein 451

chr13_-_32781716 0.162 ENSMUST00000134352.1
ENSMUST00000057428.4
Mylk4

myosin light chain kinase family, member 4

chr17_-_32886083 0.134 ENSMUST00000178401.1
Zfp870
zinc finger protein 870
chr17_+_28272191 0.129 ENSMUST00000169040.1
Ppard
peroxisome proliferator activator receptor delta
chr8_+_105900421 0.116 ENSMUST00000049699.8
Pskh1
protein serine kinase H1
chr1_+_115684727 0.101 ENSMUST00000043725.7
Cntnap5a
contactin associated protein-like 5A
chr11_-_96075655 0.092 ENSMUST00000090541.5
Atp5g1
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c1 (subunit 9)
chr16_-_52296924 0.080 ENSMUST00000167115.1
Alcam
activated leukocyte cell adhesion molecule
chr7_+_126695355 0.077 ENSMUST00000130498.1
Bola2
bolA-like 2 (E. coli)
chr3_-_62506970 0.049 ENSMUST00000029336.4
Dhx36
DEAH (Asp-Glu-Ala-His) box polypeptide 36
chr19_+_60811574 0.043 ENSMUST00000128357.1
ENSMUST00000119633.1
ENSMUST00000025957.8
Fam45a


family with sequence similarity 45, member A


chr4_-_42034726 0.038 ENSMUST00000084677.2
Gm21093
predicted gene, 21093
chr7_+_29983948 0.037 ENSMUST00000148442.1
Zfp568
zinc finger protein 568
chr4_+_3938888 0.037 ENSMUST00000121110.1
ENSMUST00000108386.1
ENSMUST00000149544.1
Chchd7


coiled-coil-helix-coiled-coil-helix domain containing 7


chr13_-_92030897 0.029 ENSMUST00000149630.1
Rasgrf2
RAS protein-specific guanine nucleotide-releasing factor 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
6.8 27.1 GO:0043490 malate-aspartate shuttle(GO:0043490)
1.3 5.3 GO:0032788 saturated monocarboxylic acid metabolic process(GO:0032788) unsaturated monocarboxylic acid metabolic process(GO:0032789)
1.2 8.7 GO:0019532 oxalate transport(GO:0019532)
1.1 5.5 GO:0045578 negative regulation of B cell differentiation(GO:0045578)
0.6 3.2 GO:0007386 compartment pattern specification(GO:0007386)
0.6 19.8 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.5 1.5 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.5 5.1 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.5 2.8 GO:0043415 positive regulation of skeletal muscle tissue regeneration(GO:0043415)
0.5 2.3 GO:0002677 negative regulation of chronic inflammatory response(GO:0002677)
0.4 3.6 GO:0090527 actin filament reorganization(GO:0090527)
0.3 1.1 GO:0046947 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.3 1.9 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.2 1.0 GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)
0.2 1.8 GO:0080184 response to stilbenoid(GO:0035634) response to phenylpropanoid(GO:0080184)
0.2 5.0 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.2 0.5 GO:2000616 negative regulation of histone H3-K9 acetylation(GO:2000616)
0.2 0.7 GO:0015793 glycerol transport(GO:0015793)
0.2 1.4 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.2 1.7 GO:0030322 stabilization of membrane potential(GO:0030322)
0.2 0.6 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.2 1.7 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.2 1.2 GO:0040031 snRNA modification(GO:0040031)
0.1 1.1 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.1 0.5 GO:1901475 pyruvate transmembrane transport(GO:1901475)
0.1 1.6 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.1 8.6 GO:0035019 somatic stem cell population maintenance(GO:0035019)
0.1 0.4 GO:0090403 regulation of purine nucleotide catabolic process(GO:0033121) negative regulation of purine nucleotide catabolic process(GO:0033122) oxidative stress-induced premature senescence(GO:0090403)
0.1 0.7 GO:1903056 melanocyte migration(GO:0097324) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.1 0.6 GO:0051684 maintenance of Golgi location(GO:0051684)
0.1 2.0 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
0.1 1.8 GO:0048240 sperm capacitation(GO:0048240)
0.1 0.6 GO:0045002 double-strand break repair via single-strand annealing(GO:0045002)
0.1 0.4 GO:0010700 negative regulation of norepinephrine secretion(GO:0010700)
0.1 0.9 GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.1 0.3 GO:0061357 Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) positive regulation of Wnt protein secretion(GO:0061357)
0.1 0.7 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.1 1.4 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.1 0.2 GO:0045829 negative regulation of isotype switching(GO:0045829)
0.1 1.2 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.1 2.2 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 0.6 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.1 0.7 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 0.2 GO:0046619 optic placode formation involved in camera-type eye formation(GO:0046619)
0.0 0.2 GO:0002544 chronic inflammatory response(GO:0002544)
0.0 0.3 GO:1902414 protein localization to cell junction(GO:1902414)
0.0 0.2 GO:1904659 glucose transmembrane transport(GO:1904659)
0.0 0.3 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 1.6 GO:0043029 T cell homeostasis(GO:0043029)
0.0 0.2 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.0 0.2 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.0 1.4 GO:0007606 sensory perception of chemical stimulus(GO:0007606)
0.0 0.5 GO:0006693 prostanoid metabolic process(GO:0006692) prostaglandin metabolic process(GO:0006693)
0.0 2.1 GO:0045580 regulation of T cell differentiation(GO:0045580)
0.0 3.3 GO:0007568 aging(GO:0007568)
0.0 0.4 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.0 0.0 GO:0090669 telomerase RNA stabilization(GO:0090669)
0.0 1.0 GO:0050729 positive regulation of inflammatory response(GO:0050729)
0.0 0.0 GO:0014022 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.8 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.2 1.2 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.2 4.6 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.1 25.1 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 33.9 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 1.4 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.1 1.6 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 2.5 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 3.5 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 2.3 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 0.7 GO:0044232 organelle membrane contact site(GO:0044232)
0.0 1.0 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.6 GO:0042555 MCM complex(GO:0042555)
0.0 1.4 GO:0031902 late endosome membrane(GO:0031902)
0.0 0.7 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.2 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.2 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 0.3 GO:0017119 Golgi transport complex(GO:0017119)
0.0 1.7 GO:0072562 blood microparticle(GO:0072562)
0.0 4.0 GO:0030027 lamellipodium(GO:0030027)
0.0 1.1 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 3.1 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.3 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.4 GO:0035861 site of double-strand break(GO:0035861)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.5 27.1 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
1.7 19.2 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
1.2 3.5 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
1.1 3.2 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
1.0 5.1 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.8 8.7 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.5 1.8 GO:0031720 haptoglobin binding(GO:0031720)
0.5 2.3 GO:0019960 C-X3-C chemokine binding(GO:0019960)
0.4 3.6 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.4 5.0 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.3 5.3 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.3 1.1 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.2 0.6 GO:0008534 oxidized purine nucleobase lesion DNA N-glycosylase activity(GO:0008534)
0.2 0.5 GO:0036132 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
0.2 0.7 GO:0015254 glycerol channel activity(GO:0015254)
0.2 1.2 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.2 1.4 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.2 1.7 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 0.6 GO:0008410 CoA-transferase activity(GO:0008410)
0.1 1.1 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.1 3.1 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 0.5 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.1 1.5 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 2.2 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.1 0.3 GO:0008192 RNA guanylyltransferase activity(GO:0008192)
0.1 1.6 GO:0045125 bioactive lipid receptor activity(GO:0045125)
0.1 2.3 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 0.2 GO:0038132 neuregulin binding(GO:0038132)
0.1 0.5 GO:0061665 SUMO ligase activity(GO:0061665)
0.1 0.3 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.1 0.3 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.1 0.3 GO:0017040 ceramidase activity(GO:0017040)
0.0 0.4 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.0 0.4 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 0.1 GO:0016501 prostacyclin receptor activity(GO:0016501)
0.0 0.7 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.0 0.2 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.3 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.0 0.2 GO:0005168 neurotrophin TRKA receptor binding(GO:0005168)
0.0 0.7 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 1.0 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 0.2 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.0 0.7 GO:0070412 R-SMAD binding(GO:0070412)
0.0 1.2 GO:0008173 RNA methyltransferase activity(GO:0008173)
0.0 1.0 GO:0001221 transcription cofactor binding(GO:0001221)
0.0 1.8 GO:0008026 ATP-dependent helicase activity(GO:0008026) purine NTP-dependent helicase activity(GO:0070035)
0.0 0.2 GO:0005355 glucose transmembrane transporter activity(GO:0005355)
0.0 0.6 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 2.0 GO:0044325 ion channel binding(GO:0044325)
0.0 0.2 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.0 4.0 GO:0005525 GTP binding(GO:0005525)
0.0 0.4 GO:0004601 peroxidase activity(GO:0004601)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.1 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 5.5 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 2.2 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 1.4 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 1.1 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.2 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.2 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 25.6 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.2 1.7 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.2 5.1 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.2 8.5 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 3.2 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 2.3 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 0.7 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 0.7 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 0.6 REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 2.4 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.6 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 2.9 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.1 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.7 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 0.4 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.2 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling