Motif ID: Gsc2_Dmbx1

Z-value: 0.759

Transcription factors associated with Gsc2_Dmbx1:

Gene SymbolEntrez IDGene Name
Dmbx1 ENSMUSG00000028707.9 Dmbx1
Gsc2 ENSMUSG00000022738.6 Gsc2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dmbx1mm10_v2_chr4_-_115939923_1159399280.534.2e-04Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Gsc2_Dmbx1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_137766474 10.809 ENSMUST00000139951.1
Alpl
alkaline phosphatase, liver/bone/kidney
chr14_-_118052235 8.819 ENSMUST00000022725.2
Dct
dopachrome tautomerase
chr4_+_154960915 7.410 ENSMUST00000049621.6
Hes5
hairy and enhancer of split 5 (Drosophila)
chr2_+_91259822 5.739 ENSMUST00000138470.1
Pacsin3
protein kinase C and casein kinase substrate in neurons 3
chr11_+_78322965 5.201 ENSMUST00000017534.8
Aldoc
aldolase C, fructose-bisphosphate
chr5_+_3344194 4.874 ENSMUST00000042410.4
Cdk6
cyclin-dependent kinase 6
chr5_+_3343893 4.687 ENSMUST00000165117.1
Cdk6
cyclin-dependent kinase 6
chr11_-_52282564 4.048 ENSMUST00000086844.3
Tcf7
transcription factor 7, T cell specific
chr13_-_116309639 3.249 ENSMUST00000036060.6
Isl1
ISL1 transcription factor, LIM/homeodomain
chr11_-_68973840 2.818 ENSMUST00000038644.4
Rangrf
RAN guanine nucleotide release factor
chr17_-_58991343 2.422 ENSMUST00000025064.7
2610034M16Rik
RIKEN cDNA 2610034M16 gene
chr17_+_35861318 2.289 ENSMUST00000074259.8
ENSMUST00000174873.1
Nrm

nurim (nuclear envelope membrane protein)

chr4_-_141053660 2.211 ENSMUST00000040222.7
Crocc
ciliary rootlet coiled-coil, rootletin
chr5_+_77265454 2.081 ENSMUST00000080359.5
Rest
RE1-silencing transcription factor
chr17_+_35861343 2.023 ENSMUST00000172931.1
Nrm
nurim (nuclear envelope membrane protein)
chr14_-_31640878 1.933 ENSMUST00000167066.1
ENSMUST00000127204.2
ENSMUST00000022437.8
Hacl1


2-hydroxyacyl-CoA lyase 1


chr2_+_164562579 1.912 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
Wfdc2


WAP four-disulfide core domain 2


chr14_+_99298652 1.801 ENSMUST00000005279.6
Klf5
Kruppel-like factor 5
chr3_-_103737995 1.735 ENSMUST00000029440.8
Olfml3
olfactomedin-like 3
chr13_+_3361029 1.707 ENSMUST00000179981.1
Gm16505
predicted gene 16505
chr1_+_44551483 1.652 ENSMUST00000074525.3
Gulp1
GULP, engulfment adaptor PTB domain containing 1
chr2_-_51972990 1.605 ENSMUST00000145481.1
ENSMUST00000112705.2
Nmi

N-myc (and STAT) interactor

chr7_-_15879844 1.561 ENSMUST00000172758.1
ENSMUST00000044434.6
Crx

cone-rod homeobox containing gene

chrX_+_134585644 1.458 ENSMUST00000113211.1
Rpl36a
ribosomal protein L36A
chr10_-_22149270 1.377 ENSMUST00000179054.1
ENSMUST00000069372.6
E030030I06Rik

RIKEN cDNA E030030I06 gene

chr8_-_113848615 1.347 ENSMUST00000093113.4
Adamts18
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 18
chr1_-_168431695 1.326 ENSMUST00000176790.1
Pbx1
pre B cell leukemia homeobox 1
chr2_-_121456693 1.306 ENSMUST00000110613.2
ENSMUST00000056312.3
Serinc4

serine incorporator 4

chr13_-_23562369 1.301 ENSMUST00000105107.1
Hist1h3e
histone cluster 1, H3e
chr11_+_98026695 1.277 ENSMUST00000092425.4
Rpl19
ribosomal protein L19
chr10_+_80292453 1.256 ENSMUST00000068408.7
ENSMUST00000062674.6
Rps15

ribosomal protein S15

chr2_-_51973219 1.252 ENSMUST00000028314.2
Nmi
N-myc (and STAT) interactor
chr16_-_35490873 1.166 ENSMUST00000023550.7
Pdia5
protein disulfide isomerase associated 5
chr1_-_168431502 1.148 ENSMUST00000064438.4
Pbx1
pre B cell leukemia homeobox 1
chr1_-_44218952 1.037 ENSMUST00000054801.3
Mettl21e
methyltransferase like 21E
chr1_+_44551650 1.006 ENSMUST00000160854.1
Gulp1
GULP, engulfment adaptor PTB domain containing 1
chr1_+_12692430 0.978 ENSMUST00000180062.1
ENSMUST00000177608.1
Sulf1

sulfatase 1

chr13_+_23752267 0.920 ENSMUST00000091703.2
Hist1h3b
histone cluster 1, H3b
chr11_-_90687572 0.853 ENSMUST00000107869.2
ENSMUST00000154599.1
ENSMUST00000107868.1
ENSMUST00000020849.2
Tom1l1



target of myb1-like 1 (chicken)



chr4_-_133968611 0.817 ENSMUST00000102552.1
Hmgn2
high mobility group nucleosomal binding domain 2
chr9_+_50617516 0.811 ENSMUST00000141366.1
Pih1d2
PIH1 domain containing 2
chr4_-_141053704 0.796 ENSMUST00000102491.3
Crocc
ciliary rootlet coiled-coil, rootletin
chr19_-_12765447 0.773 ENSMUST00000112933.1
Cntf
ciliary neurotrophic factor
chr2_+_121456963 0.759 ENSMUST00000126764.1
Hypk
huntingtin interacting protein K
chr9_-_60838200 0.747 ENSMUST00000063858.7
Gm9869
predicted gene 9869
chr1_-_168431896 0.746 ENSMUST00000176540.1
Pbx1
pre B cell leukemia homeobox 1
chr13_-_97747373 0.739 ENSMUST00000123535.1
5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr13_-_21783391 0.737 ENSMUST00000099704.3
Hist1h3i
histone cluster 1, H3i
chr19_-_47919269 0.672 ENSMUST00000095998.5
Itprip
inositol 1,4,5-triphosphate receptor interacting protein
chr19_+_46056539 0.628 ENSMUST00000111899.1
ENSMUST00000099392.3
ENSMUST00000062322.4
Pprc1


peroxisome proliferative activated receptor, gamma, coactivator-related 1


chr15_-_74734313 0.605 ENSMUST00000023260.3
Lypd2
Ly6/Plaur domain containing 2
chr12_+_81631369 0.567 ENSMUST00000036116.5
Ttc9
tetratricopeptide repeat domain 9
chr4_+_84884418 0.562 ENSMUST00000169371.2
Cntln
centlein, centrosomal protein
chr13_-_113618549 0.549 ENSMUST00000109241.3
Snx18
sorting nexin 18
chr5_-_96161990 0.536 ENSMUST00000155901.1
Cnot6l
CCR4-NOT transcription complex, subunit 6-like
chr19_+_36083696 0.527 ENSMUST00000025714.7
Rpp30
ribonuclease P/MRP 30 subunit
chr7_-_105752193 0.415 ENSMUST00000033184.4
Tpp1
tripeptidyl peptidase I
chr16_-_76403673 0.410 ENSMUST00000052867.7
Gm9843
predicted gene 9843
chr19_+_43752996 0.366 ENSMUST00000026199.7
ENSMUST00000112047.3
ENSMUST00000153295.1
Cutc


cutC copper transporter homolog (E.coli)


chr14_-_54617993 0.338 ENSMUST00000022803.4
Psmb5
proteasome (prosome, macropain) subunit, beta type 5
chr2_-_73486456 0.323 ENSMUST00000141264.1
Wipf1
WAS/WASL interacting protein family, member 1
chr2_-_9883993 0.292 ENSMUST00000114915.2
9230102O04Rik
RIKEN cDNA 9230102O04 gene
chr2_-_30093642 0.269 ENSMUST00000102865.4
Zdhhc12
zinc finger, DHHC domain containing 12
chr1_+_178187417 0.266 ENSMUST00000161075.1
ENSMUST00000027783.7
Desi2

desumoylating isopeptidase 2

chr7_-_127725616 0.252 ENSMUST00000076091.2
Ctf2
cardiotrophin 2
chr11_+_4186789 0.248 ENSMUST00000041042.6
ENSMUST00000180088.1
Tbc1d10a

TBC1 domain family, member 10a

chr2_-_30093607 0.233 ENSMUST00000081838.6
Zdhhc12
zinc finger, DHHC domain containing 12
chr2_-_24049389 0.224 ENSMUST00000051416.5
Hnmt
histamine N-methyltransferase
chr2_+_91265252 0.201 ENSMUST00000028691.6
Arfgap2
ADP-ribosylation factor GTPase activating protein 2
chr3_-_8964037 0.200 ENSMUST00000091354.5
ENSMUST00000094381.4
Tpd52

tumor protein D52

chr13_+_75089826 0.198 ENSMUST00000022075.4
Pcsk1
proprotein convertase subtilisin/kexin type 1
chr7_-_80403315 0.194 ENSMUST00000147150.1
Furin
furin (paired basic amino acid cleaving enzyme)
chr11_-_5099036 0.156 ENSMUST00000102930.3
Ewsr1
Ewing sarcoma breakpoint region 1
chr19_-_53371766 0.136 ENSMUST00000086887.1
Gm10197
predicted gene 10197
chrM_+_8600 0.126 ENSMUST00000082409.1
mt-Co3
mitochondrially encoded cytochrome c oxidase III
chr4_+_102589687 0.113 ENSMUST00000097949.4
ENSMUST00000106901.1
Pde4b

phosphodiesterase 4B, cAMP specific

chr11_+_5099406 0.104 ENSMUST00000134267.1
ENSMUST00000036320.5
ENSMUST00000150632.1
Rhbdd3


rhomboid domain containing 3


chr11_+_23256566 0.104 ENSMUST00000136235.1
Xpo1
exportin 1, CRM1 homolog (yeast)
chr8_+_13405080 0.101 ENSMUST00000033827.7
Grk1
G protein-coupled receptor kinase 1
chr7_+_101969796 0.080 ENSMUST00000084852.5
Numa1
nuclear mitotic apparatus protein 1
chr1_+_177444653 0.078 ENSMUST00000094276.3
Zbtb18
zinc finger and BTB domain containing 18
chr6_-_59426279 0.077 ENSMUST00000051065.4
Gprin3
GPRIN family member 3
chrX_+_7728439 0.061 ENSMUST00000033489.7
Praf2
PRA1 domain family 2
chr11_-_5099223 0.052 ENSMUST00000079949.6
Ewsr1
Ewing sarcoma breakpoint region 1
chr11_-_5099053 0.052 ENSMUST00000093365.5
ENSMUST00000073308.4
Ewsr1

Ewing sarcoma breakpoint region 1

chrX_-_23285532 0.048 ENSMUST00000115319.2
Klhl13
kelch-like 13
chr8_-_60954726 0.023 ENSMUST00000110302.1
Clcn3
chloride channel 3
chr4_-_139833524 0.015 ENSMUST00000030508.7
Pax7
paired box gene 7
chr1_-_92473801 0.010 ENSMUST00000027478.6
Ndufa10
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10
chr16_-_4213404 0.008 ENSMUST00000023165.6
Crebbp
CREB binding protein
chr17_-_35164891 0.001 ENSMUST00000025253.5
Prrc2a
proline-rich coiled-coil 2A

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 7.4 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
1.5 8.8 GO:0006570 tyrosine metabolic process(GO:0006570)
1.4 9.6 GO:0044838 cell quiescence(GO:0044838)
1.1 3.2 GO:0032650 regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730) cardiac cell fate determination(GO:0060913)
1.0 2.9 GO:1902524 interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.8 3.0 GO:0032053 ciliary basal body organization(GO:0032053)
0.5 2.1 GO:2000705 regulation of dense core granule biogenesis(GO:2000705)
0.5 5.2 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.5 4.0 GO:0002681 somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153)
0.5 2.8 GO:0086028 bundle of His cell to Purkinje myocyte signaling(GO:0086028) bundle of His cell action potential(GO:0086043)
0.4 1.9 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.3 10.8 GO:0046677 response to antibiotic(GO:0046677)
0.3 0.8 GO:0048687 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
0.3 1.8 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.2 1.0 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.2 5.7 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 1.1 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.1 0.5 GO:0036089 cleavage furrow formation(GO:0036089)
0.1 3.2 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971)
0.1 1.3 GO:0090331 negative regulation of platelet aggregation(GO:0090331)
0.1 3.0 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.1 0.5 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.1 0.2 GO:0001692 histamine metabolic process(GO:0001692) imidazole-containing compound catabolic process(GO:0052805)
0.0 2.7 GO:0006911 phagocytosis, engulfment(GO:0006911)
0.0 0.2 GO:0090472 dibasic protein processing(GO:0090472)
0.0 0.5 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.0 0.6 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.0 0.8 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.0 0.1 GO:0016056 photoreceptor cell morphogenesis(GO:0008594) rhodopsin mediated signaling pathway(GO:0016056) post-embryonic retina morphogenesis in camera-type eye(GO:0060060)
0.0 0.9 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.0 1.7 GO:0010389 regulation of G2/M transition of mitotic cell cycle(GO:0010389)
0.0 0.4 GO:0055070 copper ion homeostasis(GO:0055070)
0.0 0.1 GO:1904778 regulation of metaphase plate congression(GO:0090235) regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.0 0.2 GO:0016486 peptide hormone processing(GO:0016486)
0.0 0.7 GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042)
0.0 0.5 GO:0018345 protein palmitoylation(GO:0018345)
0.0 1.2 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 0.4 GO:0043171 peptide catabolic process(GO:0043171)
0.0 1.9 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.0 1.0 GO:0007601 visual perception(GO:0007601)
0.0 0.3 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 10.8 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.3 8.8 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.3 0.8 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.2 4.3 GO:0005652 nuclear lamina(GO:0005652)
0.2 11.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 3.0 GO:0035253 ciliary rootlet(GO:0035253)
0.1 4.0 GO:0005719 nuclear euchromatin(GO:0005719)
0.1 3.0 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 0.5 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 2.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 2.8 GO:0014704 intercalated disc(GO:0014704)
0.0 0.5 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 3.2 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.1 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 0.3 GO:0005839 proteasome core complex(GO:0005839)
0.0 0.2 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 9.6 GO:0098770 FBXO family protein binding(GO:0098770)
2.7 10.8 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.9 5.2 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.7 8.8 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.4 5.7 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.4 1.9 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.2 1.9 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.2 1.3 GO:1990932 5.8S rRNA binding(GO:1990932)
0.2 1.0 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.2 2.1 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.1 1.0 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.1 1.6 GO:0043522 leucine zipper domain binding(GO:0043522)
0.1 1.2 GO:0015037 peptide disulfide oxidoreductase activity(GO:0015037)
0.1 0.4 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.1 1.3 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.1 3.2 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 3.1 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin binding(GO:0030332)
0.1 2.8 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 3.0 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.5 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 11.5 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.8 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 0.5 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.1 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.0 0.2 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 0.5 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 1.2 GO:0019894 kinesin binding(GO:0019894)
0.0 0.3 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 1.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 5.0 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 0.9 GO:0030295 protein kinase activator activity(GO:0030295)
0.0 0.6 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 9.6 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 7.4 PID_CDC42_PATHWAY CDC42 signaling events
0.0 3.9 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.7 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.0 2.3 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.4 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.2 9.6 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 5.2 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.1 7.4 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 1.9 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 3.0 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 4.0 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.0 1.8 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.6 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.2 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins