Motif ID: Spic
Z-value: 0.721

Transcription factors associated with Spic:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Spic | ENSMUSG00000004359.10 | Spic |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Spic | mm10_v2_chr10_-_88683021_88683025 | 0.10 | 5.4e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 2.2 | GO:0050904 | diapedesis(GO:0050904) |
0.5 | 1.5 | GO:0001803 | type III hypersensitivity(GO:0001802) regulation of type III hypersensitivity(GO:0001803) positive regulation of type III hypersensitivity(GO:0001805) |
0.4 | 1.3 | GO:0060785 | regulation of apoptosis involved in tissue homeostasis(GO:0060785) |
0.4 | 0.8 | GO:2000157 | regulation of protein K48-linked deubiquitination(GO:1903093) negative regulation of protein K48-linked deubiquitination(GO:1903094) negative regulation of ubiquitin-specific protease activity(GO:2000157) |
0.4 | 2.7 | GO:0045650 | negative regulation of macrophage differentiation(GO:0045650) |
0.4 | 1.8 | GO:0033864 | positive regulation of NAD(P)H oxidase activity(GO:0033864) positive regulation of toll-like receptor 2 signaling pathway(GO:0034137) |
0.3 | 1.0 | GO:0098501 | polynucleotide dephosphorylation(GO:0098501) |
0.3 | 0.8 | GO:0003274 | endocardial cushion fusion(GO:0003274) |
0.3 | 0.3 | GO:0016068 | regulation of type I hypersensitivity(GO:0001810) type I hypersensitivity(GO:0016068) |
0.3 | 2.7 | GO:0019243 | methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727) |
0.3 | 0.8 | GO:0070476 | rRNA (guanine-N7)-methylation(GO:0070476) |
0.3 | 2.3 | GO:0071569 | protein ufmylation(GO:0071569) |
0.2 | 0.4 | GO:0002309 | T cell proliferation involved in immune response(GO:0002309) |
0.2 | 2.2 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
0.2 | 0.7 | GO:0016998 | cell wall macromolecule catabolic process(GO:0016998) |
0.2 | 0.6 | GO:0045014 | detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) detection of glucose(GO:0051594) |
0.2 | 0.6 | GO:1904431 | positive regulation of t-circle formation(GO:1904431) |
0.2 | 1.0 | GO:0038032 | termination of G-protein coupled receptor signaling pathway(GO:0038032) |
0.2 | 0.6 | GO:0045658 | regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659) |
0.2 | 0.8 | GO:0071051 | polyadenylation-dependent snoRNA 3'-end processing(GO:0071051) |
0.2 | 0.8 | GO:0010700 | negative regulation of norepinephrine secretion(GO:0010700) |
0.2 | 0.6 | GO:2001180 | negative regulation of interleukin-18 production(GO:0032701) negative regulation of interleukin-10 secretion(GO:2001180) |
0.2 | 0.6 | GO:0032240 | mRNA export from nucleus in response to heat stress(GO:0031990) negative regulation of nucleobase-containing compound transport(GO:0032240) negative regulation of RNA export from nucleus(GO:0046832) |
0.2 | 1.1 | GO:1901164 | negative regulation of trophoblast cell migration(GO:1901164) |
0.2 | 0.8 | GO:0046947 | hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947) |
0.2 | 2.7 | GO:0021902 | commitment of neuronal cell to specific neuron type in forebrain(GO:0021902) |
0.2 | 0.5 | GO:1902220 | positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902220) |
0.2 | 0.5 | GO:0002314 | germinal center B cell differentiation(GO:0002314) |
0.2 | 1.0 | GO:0035878 | nail development(GO:0035878) |
0.2 | 0.5 | GO:1900673 | olefin metabolic process(GO:1900673) |
0.2 | 1.1 | GO:0001955 | blood vessel maturation(GO:0001955) |
0.1 | 0.4 | GO:1904578 | response to thapsigargin(GO:1904578) cellular response to thapsigargin(GO:1904579) |
0.1 | 1.6 | GO:0006488 | dolichol-linked oligosaccharide biosynthetic process(GO:0006488) |
0.1 | 1.6 | GO:2000580 | positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582) |
0.1 | 0.3 | GO:0034427 | nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'(GO:0034427) |
0.1 | 1.8 | GO:0061299 | retina vasculature morphogenesis in camera-type eye(GO:0061299) |
0.1 | 0.4 | GO:0070172 | positive regulation of tooth mineralization(GO:0070172) |
0.1 | 0.6 | GO:0072717 | cellular response to actinomycin D(GO:0072717) |
0.1 | 2.1 | GO:0071577 | zinc II ion transmembrane transport(GO:0071577) |
0.1 | 1.5 | GO:0015816 | glycine transport(GO:0015816) |
0.1 | 1.0 | GO:0051103 | DNA ligation involved in DNA repair(GO:0051103) |
0.1 | 2.2 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
0.1 | 0.6 | GO:0071955 | recycling endosome to Golgi transport(GO:0071955) |
0.1 | 0.3 | GO:0044313 | protein K6-linked deubiquitination(GO:0044313) |
0.1 | 0.7 | GO:0097428 | protein maturation by iron-sulfur cluster transfer(GO:0097428) |
0.1 | 1.7 | GO:0035493 | SNARE complex assembly(GO:0035493) |
0.1 | 0.5 | GO:0031125 | rRNA 3'-end processing(GO:0031125) |
0.1 | 0.5 | GO:0090370 | negative regulation of cholesterol efflux(GO:0090370) |
0.1 | 1.4 | GO:0030574 | collagen catabolic process(GO:0030574) |
0.1 | 1.6 | GO:0006744 | ubiquinone biosynthetic process(GO:0006744) |
0.1 | 0.5 | GO:0016557 | peroxisome membrane biogenesis(GO:0016557) regulation of peroxisome size(GO:0044375) |
0.1 | 0.3 | GO:1905076 | regulation of interleukin-17 secretion(GO:1905076) positive regulation of T-helper 17 type immune response(GO:2000318) |
0.1 | 1.0 | GO:1903818 | positive regulation of voltage-gated potassium channel activity(GO:1903818) |
0.1 | 0.2 | GO:1903070 | negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070) |
0.1 | 0.5 | GO:0071699 | olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699) |
0.1 | 0.3 | GO:2000152 | regulation of ubiquitin-specific protease activity(GO:2000152) |
0.1 | 0.6 | GO:0002361 | CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361) |
0.1 | 2.0 | GO:0045026 | plasma membrane fusion(GO:0045026) |
0.1 | 0.2 | GO:1904569 | regulation of selenocysteine incorporation(GO:1904569) |
0.1 | 0.3 | GO:0016559 | peroxisome fission(GO:0016559) |
0.1 | 0.4 | GO:1901727 | positive regulation of histone deacetylase activity(GO:1901727) |
0.1 | 0.2 | GO:0045869 | negative regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045869) |
0.1 | 0.3 | GO:0030854 | positive regulation of granulocyte differentiation(GO:0030854) |
0.1 | 1.1 | GO:0009083 | branched-chain amino acid catabolic process(GO:0009083) |
0.1 | 0.4 | GO:0010730 | negative regulation of hydrogen peroxide metabolic process(GO:0010727) negative regulation of hydrogen peroxide biosynthetic process(GO:0010730) |
0.1 | 0.2 | GO:2001187 | positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187) |
0.1 | 1.3 | GO:0000731 | DNA synthesis involved in DNA repair(GO:0000731) |
0.1 | 1.2 | GO:0034315 | regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315) |
0.1 | 0.2 | GO:0048611 | ectodermal digestive tract development(GO:0007439) embryonic ectodermal digestive tract development(GO:0048611) |
0.1 | 0.2 | GO:0051771 | negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771) |
0.1 | 0.7 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
0.1 | 0.4 | GO:0006390 | transcription from mitochondrial promoter(GO:0006390) |
0.1 | 0.5 | GO:0016446 | somatic hypermutation of immunoglobulin genes(GO:0016446) |
0.0 | 0.1 | GO:0090289 | regulation of osteoclast proliferation(GO:0090289) |
0.0 | 0.8 | GO:1901741 | positive regulation of myoblast fusion(GO:1901741) |
0.0 | 1.1 | GO:0007035 | vacuolar acidification(GO:0007035) |
0.0 | 0.4 | GO:0090037 | positive regulation of protein kinase C signaling(GO:0090037) |
0.0 | 0.2 | GO:0035405 | histone-threonine phosphorylation(GO:0035405) |
0.0 | 0.1 | GO:0035928 | rRNA import into mitochondrion(GO:0035928) |
0.0 | 0.7 | GO:0031532 | actin cytoskeleton reorganization(GO:0031532) |
0.0 | 0.3 | GO:0000056 | ribosomal small subunit export from nucleus(GO:0000056) |
0.0 | 0.5 | GO:2000650 | negative regulation of sodium ion transmembrane transporter activity(GO:2000650) |
0.0 | 0.6 | GO:0006829 | zinc II ion transport(GO:0006829) |
0.0 | 0.3 | GO:0007195 | adenosine receptor signaling pathway(GO:0001973) adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195) |
0.0 | 1.7 | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading(GO:1900026) |
0.0 | 0.2 | GO:0034379 | very-low-density lipoprotein particle assembly(GO:0034379) |
0.0 | 0.5 | GO:0006388 | tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388) |
0.0 | 0.6 | GO:0060363 | cranial suture morphogenesis(GO:0060363) |
0.0 | 0.2 | GO:0038063 | collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) |
0.0 | 0.3 | GO:1900364 | negative regulation of mRNA polyadenylation(GO:1900364) |
0.0 | 0.1 | GO:1901069 | guanosine-containing compound catabolic process(GO:1901069) |
0.0 | 0.3 | GO:0009396 | folic acid-containing compound biosynthetic process(GO:0009396) |
0.0 | 0.2 | GO:0006072 | glycerol-3-phosphate metabolic process(GO:0006072) |
0.0 | 0.2 | GO:0072697 | protein localization to cell cortex(GO:0072697) |
0.0 | 0.3 | GO:0035330 | regulation of hippo signaling(GO:0035330) |
0.0 | 0.2 | GO:0071476 | cellular hypotonic response(GO:0071476) |
0.0 | 0.1 | GO:0017185 | peptidyl-lysine hydroxylation(GO:0017185) |
0.0 | 0.4 | GO:0090161 | Golgi ribbon formation(GO:0090161) |
0.0 | 0.1 | GO:1904809 | dense core granule localization(GO:0032253) dense core granule transport(GO:1901950) regulation of dense core granule transport(GO:1904809) positive regulation of dense core granule transport(GO:1904811) |
0.0 | 0.4 | GO:0070935 | 3'-UTR-mediated mRNA stabilization(GO:0070935) |
0.0 | 0.6 | GO:1903861 | positive regulation of dendrite extension(GO:1903861) |
0.0 | 0.2 | GO:0033008 | positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of mast cell degranulation(GO:0043306) |
0.0 | 0.5 | GO:0002495 | antigen processing and presentation of peptide antigen via MHC class II(GO:0002495) |
0.0 | 0.5 | GO:0000338 | protein deneddylation(GO:0000338) |
0.0 | 0.1 | GO:0017183 | peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183) |
0.0 | 0.3 | GO:0031145 | anaphase-promoting complex-dependent catabolic process(GO:0031145) |
0.0 | 0.3 | GO:0034314 | Arp2/3 complex-mediated actin nucleation(GO:0034314) |
0.0 | 0.1 | GO:0006742 | NADP catabolic process(GO:0006742) pyridine nucleotide catabolic process(GO:0019364) |
0.0 | 1.6 | GO:0038083 | peptidyl-tyrosine autophosphorylation(GO:0038083) |
0.0 | 0.1 | GO:0007406 | negative regulation of neuroblast proliferation(GO:0007406) |
0.0 | 0.3 | GO:0019363 | pyridine nucleotide biosynthetic process(GO:0019363) |
0.0 | 0.2 | GO:0061002 | negative regulation of dendritic spine morphogenesis(GO:0061002) |
0.0 | 0.1 | GO:0006983 | ER overload response(GO:0006983) |
0.0 | 0.1 | GO:0090024 | negative regulation of granulocyte chemotaxis(GO:0071623) negative regulation of neutrophil chemotaxis(GO:0090024) |
0.0 | 0.2 | GO:0001682 | tRNA 5'-leader removal(GO:0001682) |
0.0 | 0.4 | GO:0038092 | nodal signaling pathway(GO:0038092) |
0.0 | 0.6 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
0.0 | 0.1 | GO:0006995 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
0.0 | 0.0 | GO:0090400 | stress-induced premature senescence(GO:0090400) |
0.0 | 0.3 | GO:0006298 | mismatch repair(GO:0006298) |
0.0 | 0.6 | GO:0003333 | amino acid transmembrane transport(GO:0003333) |
0.0 | 0.2 | GO:0003413 | chondrocyte differentiation involved in endochondral bone morphogenesis(GO:0003413) |
0.0 | 0.7 | GO:0060325 | face morphogenesis(GO:0060325) |
0.0 | 0.7 | GO:1901998 | toxin transport(GO:1901998) |
0.0 | 0.1 | GO:0006788 | heme oxidation(GO:0006788) |
0.0 | 0.3 | GO:0048268 | clathrin coat assembly(GO:0048268) |
0.0 | 2.2 | GO:1990830 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
0.0 | 0.3 | GO:0051016 | barbed-end actin filament capping(GO:0051016) |
0.0 | 0.1 | GO:0006544 | glycine metabolic process(GO:0006544) |
0.0 | 0.2 | GO:0016486 | peptide hormone processing(GO:0016486) |
0.0 | 0.1 | GO:0006013 | mannose metabolic process(GO:0006013) |
0.0 | 0.1 | GO:0002862 | negative regulation of inflammatory response to antigenic stimulus(GO:0002862) |
0.0 | 0.2 | GO:0045116 | protein neddylation(GO:0045116) |
0.0 | 1.5 | GO:0051607 | defense response to virus(GO:0051607) |
0.0 | 0.4 | GO:0046329 | negative regulation of JNK cascade(GO:0046329) |
0.0 | 0.1 | GO:0030213 | hyaluronan biosynthetic process(GO:0030213) |
0.0 | 0.0 | GO:0043651 | linoleic acid metabolic process(GO:0043651) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 1.6 | GO:1990257 | piccolo-bassoon transport vesicle(GO:1990257) |
0.4 | 1.3 | GO:0043625 | delta DNA polymerase complex(GO:0043625) |
0.4 | 2.2 | GO:0030485 | smooth muscle contractile fiber(GO:0030485) |
0.4 | 1.9 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
0.3 | 1.1 | GO:0005947 | mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) |
0.2 | 1.2 | GO:0070820 | tertiary granule(GO:0070820) |
0.2 | 1.2 | GO:1990393 | 3M complex(GO:1990393) |
0.2 | 0.9 | GO:0042719 | mitochondrial intermembrane space protein transporter complex(GO:0042719) |
0.2 | 0.7 | GO:0008282 | ATP-sensitive potassium channel complex(GO:0008282) |
0.2 | 1.0 | GO:0005958 | DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) DNA ligase IV complex(GO:0032807) |
0.2 | 1.7 | GO:0042581 | specific granule(GO:0042581) |
0.2 | 1.1 | GO:0000220 | vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) |
0.1 | 0.7 | GO:0048237 | rough endoplasmic reticulum lumen(GO:0048237) |
0.1 | 0.5 | GO:0044307 | dendritic branch(GO:0044307) |
0.1 | 0.3 | GO:0097543 | ciliary inversin compartment(GO:0097543) |
0.1 | 0.3 | GO:0035061 | interchromatin granule(GO:0035061) |
0.1 | 0.3 | GO:0099631 | postsynaptic endocytic zone cytoplasmic component(GO:0099631) |
0.1 | 0.6 | GO:0044615 | nuclear pore nuclear basket(GO:0044615) |
0.1 | 0.5 | GO:0031021 | interphase microtubule organizing center(GO:0031021) |
0.1 | 0.3 | GO:0055087 | Ski complex(GO:0055087) |
0.1 | 0.2 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
0.1 | 5.4 | GO:0005581 | collagen trimer(GO:0005581) |
0.1 | 0.6 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
0.1 | 0.8 | GO:0000176 | nuclear exosome (RNase complex)(GO:0000176) |
0.1 | 0.5 | GO:0033263 | CORVET complex(GO:0033263) |
0.1 | 1.0 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
0.1 | 0.6 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
0.1 | 0.8 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
0.1 | 1.6 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
0.1 | 3.0 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
0.1 | 0.2 | GO:0032021 | NELF complex(GO:0032021) |
0.1 | 0.2 | GO:0005965 | protein farnesyltransferase complex(GO:0005965) |
0.1 | 0.2 | GO:0098888 | extrinsic component of presynaptic membrane(GO:0098888) |
0.0 | 0.5 | GO:0072669 | tRNA-splicing ligase complex(GO:0072669) |
0.0 | 0.3 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
0.0 | 0.2 | GO:0009331 | glycerol-3-phosphate dehydrogenase complex(GO:0009331) |
0.0 | 0.5 | GO:0031209 | SCAR complex(GO:0031209) |
0.0 | 0.1 | GO:0030121 | AP-1 adaptor complex(GO:0030121) |
0.0 | 0.2 | GO:0000172 | ribonuclease MRP complex(GO:0000172) |
0.0 | 0.1 | GO:0097651 | phosphatidylinositol 3-kinase complex, class I(GO:0097651) |
0.0 | 0.2 | GO:1990745 | EARP complex(GO:1990745) |
0.0 | 0.3 | GO:0005785 | signal recognition particle receptor complex(GO:0005785) |
0.0 | 2.4 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
0.0 | 1.0 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) |
0.0 | 0.4 | GO:0005869 | dynactin complex(GO:0005869) |
0.0 | 0.3 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
0.0 | 1.0 | GO:0030673 | axolemma(GO:0030673) |
0.0 | 0.2 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
0.0 | 0.2 | GO:0034709 | methylosome(GO:0034709) |
0.0 | 2.4 | GO:0000118 | histone deacetylase complex(GO:0000118) |
0.0 | 0.6 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
0.0 | 0.6 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
0.0 | 0.8 | GO:0097440 | apical dendrite(GO:0097440) |
0.0 | 0.9 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
0.0 | 0.3 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
0.0 | 0.6 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
0.0 | 0.3 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
0.0 | 0.3 | GO:0048188 | Set1C/COMPASS complex(GO:0048188) |
0.0 | 0.2 | GO:0002080 | acrosomal membrane(GO:0002080) |
0.0 | 1.6 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
0.0 | 0.0 | GO:0070985 | TFIIK complex(GO:0070985) |
0.0 | 1.3 | GO:0005901 | caveola(GO:0005901) |
0.0 | 0.5 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
0.0 | 0.1 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
0.0 | 0.3 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
0.0 | 0.2 | GO:0008305 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
0.0 | 0.5 | GO:0008180 | COP9 signalosome(GO:0008180) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 1.9 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
0.4 | 1.3 | GO:0072541 | peroxynitrite reductase activity(GO:0072541) |
0.4 | 2.2 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
0.3 | 2.7 | GO:0004416 | hydroxyacylglutathione hydrolase activity(GO:0004416) |
0.3 | 1.8 | GO:0019864 | immunoglobulin receptor activity(GO:0019763) IgG binding(GO:0019864) |
0.3 | 0.9 | GO:0046964 | 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity(GO:0046964) |
0.2 | 0.7 | GO:0071568 | UFM1 transferase activity(GO:0071568) |
0.2 | 0.7 | GO:0003796 | lysozyme activity(GO:0003796) |
0.2 | 0.8 | GO:0036435 | K48-linked polyubiquitin binding(GO:0036435) |
0.2 | 0.8 | GO:0034714 | type III transforming growth factor beta receptor binding(GO:0034714) |
0.2 | 1.0 | GO:0046403 | polynucleotide 3'-phosphatase activity(GO:0046403) |
0.2 | 0.8 | GO:0008475 | procollagen-lysine 5-dioxygenase activity(GO:0008475) |
0.2 | 0.5 | GO:0035673 | oligopeptide transmembrane transporter activity(GO:0035673) |
0.2 | 0.5 | GO:0005118 | sevenless binding(GO:0005118) |
0.2 | 1.1 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
0.2 | 1.0 | GO:1990599 | 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599) |
0.1 | 1.5 | GO:0015187 | glycine transmembrane transporter activity(GO:0015187) |
0.1 | 1.2 | GO:0070180 | large ribosomal subunit rRNA binding(GO:0070180) |
0.1 | 0.8 | GO:0016936 | galactoside binding(GO:0016936) |
0.1 | 0.6 | GO:0017108 | 5'-flap endonuclease activity(GO:0017108) |
0.1 | 0.6 | GO:0051425 | PTB domain binding(GO:0051425) |
0.1 | 0.6 | GO:0070051 | fibrinogen binding(GO:0070051) |
0.1 | 0.4 | GO:0000179 | rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) |
0.1 | 0.6 | GO:0004920 | interleukin-10 receptor activity(GO:0004920) |
0.1 | 2.8 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
0.1 | 1.0 | GO:0004679 | AMP-activated protein kinase activity(GO:0004679) |
0.1 | 0.3 | GO:0035800 | deubiquitinase activator activity(GO:0035800) |
0.1 | 1.1 | GO:0016624 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624) |
0.1 | 1.7 | GO:0097371 | MDM2/MDM4 family protein binding(GO:0097371) |
0.1 | 1.6 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
0.1 | 1.1 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
0.1 | 0.8 | GO:0005432 | calcium:sodium antiporter activity(GO:0005432) |
0.1 | 0.5 | GO:1904315 | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315) |
0.1 | 0.2 | GO:1990955 | G-rich single-stranded DNA binding(GO:1990955) |
0.1 | 1.8 | GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) |
0.1 | 0.2 | GO:0035402 | histone kinase activity (H3-T11 specific)(GO:0035402) |
0.1 | 0.2 | GO:0016901 | glycerol-3-phosphate dehydrogenase activity(GO:0004368) oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901) |
0.1 | 0.5 | GO:0016248 | ion channel inhibitor activity(GO:0008200) channel inhibitor activity(GO:0016248) |
0.1 | 1.7 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
0.1 | 0.4 | GO:0005021 | vascular endothelial growth factor-activated receptor activity(GO:0005021) |
0.1 | 0.2 | GO:1904288 | BAT3 complex binding(GO:1904288) |
0.1 | 2.0 | GO:0043394 | proteoglycan binding(GO:0043394) |
0.1 | 0.2 | GO:0004660 | protein farnesyltransferase activity(GO:0004660) |
0.1 | 0.6 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
0.1 | 1.0 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
0.1 | 0.3 | GO:0008294 | calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294) |
0.1 | 0.7 | GO:0031386 | protein tag(GO:0031386) |
0.0 | 0.5 | GO:0008656 | cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656) |
0.0 | 1.7 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
0.0 | 0.3 | GO:0045322 | unmethylated CpG binding(GO:0045322) |
0.0 | 0.3 | GO:0001609 | G-protein coupled adenosine receptor activity(GO:0001609) |
0.0 | 0.2 | GO:0035368 | selenocysteine insertion sequence binding(GO:0035368) |
0.0 | 0.4 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
0.0 | 1.2 | GO:0050750 | low-density lipoprotein particle receptor binding(GO:0050750) |
0.0 | 0.5 | GO:0045125 | bioactive lipid receptor activity(GO:0045125) |
0.0 | 2.1 | GO:0004714 | transmembrane receptor protein tyrosine kinase activity(GO:0004714) |
0.0 | 1.4 | GO:0005484 | SNAP receptor activity(GO:0005484) |
0.0 | 1.0 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
0.0 | 0.2 | GO:0009019 | tRNA (guanine-N1-)-methyltransferase activity(GO:0009019) |
0.0 | 4.8 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
0.0 | 0.3 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
0.0 | 0.2 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
0.0 | 0.1 | GO:0004875 | complement receptor activity(GO:0004875) |
0.0 | 0.1 | GO:0008607 | phosphorylase kinase regulator activity(GO:0008607) |
0.0 | 0.1 | GO:0008517 | folic acid transporter activity(GO:0008517) |
0.0 | 0.8 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
0.0 | 0.2 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
0.0 | 0.6 | GO:0070840 | dynein complex binding(GO:0070840) |
0.0 | 0.5 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
0.0 | 0.3 | GO:0042288 | MHC class I protein binding(GO:0042288) |
0.0 | 0.2 | GO:0004526 | ribonuclease P activity(GO:0004526) |
0.0 | 0.5 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
0.0 | 0.1 | GO:0046935 | 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935) |
0.0 | 0.2 | GO:0034711 | inhibin binding(GO:0034711) |
0.0 | 0.3 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
0.0 | 0.3 | GO:0016290 | palmitoyl-CoA hydrolase activity(GO:0016290) |
0.0 | 0.3 | GO:0035613 | RNA stem-loop binding(GO:0035613) |
0.0 | 0.3 | GO:0005542 | folic acid binding(GO:0005542) |
0.0 | 0.3 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
0.0 | 0.1 | GO:0004392 | heme oxygenase (decyclizing) activity(GO:0004392) |
0.0 | 0.2 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
0.0 | 0.4 | GO:0050699 | WW domain binding(GO:0050699) |
0.0 | 0.6 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
0.0 | 1.0 | GO:0019905 | syntaxin binding(GO:0019905) |
0.0 | 0.5 | GO:0004601 | peroxidase activity(GO:0004601) |
0.0 | 0.7 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
0.0 | 0.4 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
0.0 | 0.4 | GO:0001671 | ATPase activator activity(GO:0001671) |
0.0 | 0.1 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
0.0 | 0.2 | GO:0008327 | methyl-CpG binding(GO:0008327) |
0.0 | 0.4 | GO:0005109 | frizzled binding(GO:0005109) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 2.5 | PID_DNA_PK_PATHWAY | DNA-PK pathway in nonhomologous end joining |
0.1 | 3.7 | PID_INTEGRIN3_PATHWAY | Beta3 integrin cell surface interactions |
0.0 | 5.9 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
0.0 | 0.4 | PID_VEGF_VEGFR_PATHWAY | VEGF and VEGFR signaling network |
0.0 | 1.9 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
0.0 | 0.2 | PID_TCR_JNK_PATHWAY | JNK signaling in the CD4+ TCR pathway |
0.0 | 2.5 | PID_FCER1_PATHWAY | Fc-epsilon receptor I signaling in mast cells |
0.0 | 0.5 | SA_PROGRAMMED_CELL_DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
0.0 | 1.2 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
0.0 | 1.0 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
0.0 | 1.2 | PID_HDAC_CLASSII_PATHWAY | Signaling events mediated by HDAC Class II |
0.0 | 0.2 | PID_P38_GAMMA_DELTA_PATHWAY | Signaling mediated by p38-gamma and p38-delta |
0.0 | 1.2 | PID_VEGFR1_2_PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
0.0 | 0.3 | PID_LPA4_PATHWAY | LPA4-mediated signaling events |
0.0 | 1.7 | PID_PDGFRB_PATHWAY | PDGFR-beta signaling pathway |
0.0 | 0.4 | PID_IL2_PI3K_PATHWAY | IL2 signaling events mediated by PI3K |
0.0 | 1.0 | PID_RHOA_REG_PATHWAY | Regulation of RhoA activity |
0.0 | 0.2 | PID_ERB_GENOMIC_PATHWAY | Validated nuclear estrogen receptor beta network |
0.0 | 0.4 | ST_P38_MAPK_PATHWAY | p38 MAPK Pathway |
0.0 | 0.3 | PID_INTEGRIN_A4B1_PATHWAY | Alpha4 beta1 integrin signaling events |
0.0 | 1.1 | WNT_SIGNALING | Genes related to Wnt-mediated signal transduction |
0.0 | 0.3 | PID_ARF_3PATHWAY | Arf1 pathway |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.9 | 5.2 | REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
0.4 | 1.2 | REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
0.2 | 1.6 | REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
0.1 | 2.0 | REACTOME_PECAM1_INTERACTIONS | Genes involved in PECAM1 interactions |
0.1 | 1.6 | REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
0.1 | 1.2 | REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
0.1 | 3.2 | REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
0.1 | 1.0 | REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
0.1 | 0.8 | REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |
0.1 | 0.6 | REACTOME_ACYL_CHAIN_REMODELLING_OF_PI | Genes involved in Acyl chain remodelling of PI |
0.1 | 0.5 | REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR | Genes involved in Trafficking and processing of endosomal TLR |
0.1 | 0.6 | REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
0.1 | 1.0 | REACTOME_INTEGRATION_OF_PROVIRUS | Genes involved in Integration of provirus |
0.1 | 2.2 | REACTOME_GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
0.1 | 0.5 | REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
0.1 | 5.5 | REACTOME_PEPTIDE_CHAIN_ELONGATION | Genes involved in Peptide chain elongation |
0.0 | 1.1 | REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
0.0 | 0.5 | REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL | Genes involved in NF-kB is activated and signals survival |
0.0 | 1.5 | REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
0.0 | 0.8 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
0.0 | 0.4 | REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
0.0 | 0.5 | REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
0.0 | 0.4 | REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING | Genes involved in Spry regulation of FGF signaling |
0.0 | 0.5 | REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
0.0 | 0.3 | REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY | Genes involved in Adenylate cyclase activating pathway |
0.0 | 0.6 | REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS | Genes involved in Regulation of gene expression in beta cells |
0.0 | 1.0 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
0.0 | 0.3 | REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
0.0 | 0.5 | REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
0.0 | 0.5 | REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
0.0 | 0.2 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
0.0 | 0.6 | REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
0.0 | 1.0 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
0.0 | 0.3 | REACTOME_GAP_JUNCTION_DEGRADATION | Genes involved in Gap junction degradation |
0.0 | 0.3 | REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
0.0 | 0.4 | REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT | Genes involved in ABC-family proteins mediated transport |
0.0 | 0.3 | REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
0.0 | 1.2 | REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION | Genes involved in MHC class II antigen presentation |
0.0 | 0.6 | REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT | Genes involved in Mitochondrial Protein Import |
0.0 | 0.3 | REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter |
0.0 | 0.2 | REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
0.0 | 0.2 | REACTOME_EGFR_DOWNREGULATION | Genes involved in EGFR downregulation |