Motif ID: Pbx1_Pbx3
Z-value: 1.252


Transcription factors associated with Pbx1_Pbx3:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Pbx1 | ENSMUSG00000052534.9 | Pbx1 |
Pbx3 | ENSMUSG00000038718.9 | Pbx3 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Pbx1 | mm10_v2_chr1_-_168432270_168432347 | -0.20 | 2.2e-01 | Click! |
Pbx3 | mm10_v2_chr2_-_34372004_34372044 | 0.10 | 5.2e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
4.2 | 12.7 | GO:0097402 | neuroblast migration(GO:0097402) |
3.0 | 8.9 | GO:0044413 | regulation of lung blood pressure(GO:0014916) evasion or tolerance of host defenses by virus(GO:0019049) positive regulation of transforming growth factor beta3 production(GO:0032916) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834) |
2.2 | 6.7 | GO:0060364 | frontal suture morphogenesis(GO:0060364) |
1.8 | 5.5 | GO:0021557 | oculomotor nerve development(GO:0021557) |
1.7 | 13.9 | GO:0048625 | myoblast fate commitment(GO:0048625) |
1.2 | 6.0 | GO:0051387 | negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387) |
1.1 | 4.3 | GO:0097168 | condensed mesenchymal cell proliferation(GO:0072137) mesenchymal stem cell proliferation(GO:0097168) |
1.0 | 6.2 | GO:1904936 | cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936) |
0.9 | 3.7 | GO:0046552 | eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552) |
0.8 | 5.1 | GO:0090005 | negative regulation of Golgi to plasma membrane protein transport(GO:0042997) negative regulation of establishment of protein localization to plasma membrane(GO:0090005) |
0.7 | 2.2 | GO:1904956 | regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041) |
0.7 | 3.6 | GO:0048852 | diencephalon morphogenesis(GO:0048852) |
0.7 | 3.3 | GO:0021764 | amygdala development(GO:0021764) |
0.6 | 1.8 | GO:0072204 | cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204) |
0.6 | 1.8 | GO:0030862 | neuroblast division in subventricular zone(GO:0021849) positive regulation of polarized epithelial cell differentiation(GO:0030862) |
0.6 | 1.7 | GO:1903225 | negative regulation of endodermal cell differentiation(GO:1903225) |
0.5 | 1.6 | GO:0072049 | comma-shaped body morphogenesis(GO:0072049) |
0.5 | 1.5 | GO:0002191 | cap-dependent translational initiation(GO:0002191) |
0.5 | 1.5 | GO:0006597 | spermine biosynthetic process(GO:0006597) |
0.5 | 2.8 | GO:0035469 | determination of pancreatic left/right asymmetry(GO:0035469) |
0.4 | 1.3 | GO:0043456 | regulation of pentose-phosphate shunt(GO:0043456) |
0.4 | 1.2 | GO:0001951 | intestinal D-glucose absorption(GO:0001951) terminal web assembly(GO:1902896) |
0.4 | 2.0 | GO:0003431 | growth plate cartilage chondrocyte development(GO:0003431) |
0.4 | 1.5 | GO:2000182 | regulation of progesterone biosynthetic process(GO:2000182) |
0.4 | 1.1 | GO:0060023 | soft palate development(GO:0060023) |
0.3 | 1.0 | GO:0060598 | dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598) |
0.3 | 1.0 | GO:1902445 | regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445) |
0.3 | 0.9 | GO:1903011 | negative regulation of bone development(GO:1903011) |
0.3 | 6.7 | GO:0060044 | negative regulation of cardiac muscle cell proliferation(GO:0060044) |
0.3 | 1.5 | GO:1903998 | regulation of eating behavior(GO:1903998) |
0.3 | 4.3 | GO:0060736 | prostate gland growth(GO:0060736) |
0.3 | 5.6 | GO:0007530 | sex determination(GO:0007530) |
0.3 | 0.8 | GO:1902336 | neuropilin signaling pathway(GO:0038189) VEGF-activated neuropilin signaling pathway(GO:0038190) positive regulation of retinal ganglion cell axon guidance(GO:1902336) |
0.3 | 1.1 | GO:0072272 | proximal/distal pattern formation involved in metanephric nephron development(GO:0072272) |
0.3 | 1.1 | GO:0060346 | bone trabecula formation(GO:0060346) |
0.3 | 4.2 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
0.2 | 4.2 | GO:0038063 | collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) |
0.2 | 0.7 | GO:1904245 | regulation of polynucleotide adenylyltransferase activity(GO:1904245) |
0.2 | 1.2 | GO:1903232 | melanosome assembly(GO:1903232) |
0.2 | 2.9 | GO:0045187 | regulation of circadian sleep/wake cycle, sleep(GO:0045187) |
0.2 | 1.3 | GO:0043383 | negative T cell selection(GO:0043383) negative thymic T cell selection(GO:0045060) |
0.2 | 2.7 | GO:0001675 | acrosome assembly(GO:0001675) |
0.2 | 1.6 | GO:2001054 | negative regulation of mesenchymal cell apoptotic process(GO:2001054) |
0.2 | 0.8 | GO:0035553 | oxidative single-stranded RNA demethylation(GO:0035553) |
0.2 | 1.8 | GO:0038166 | angiotensin-activated signaling pathway(GO:0038166) |
0.2 | 0.9 | GO:0001561 | fatty acid alpha-oxidation(GO:0001561) |
0.2 | 1.4 | GO:0045541 | negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206) |
0.2 | 0.5 | GO:0016256 | N-glycan processing to lysosome(GO:0016256) |
0.2 | 1.8 | GO:0070836 | caveola assembly(GO:0070836) |
0.2 | 1.1 | GO:0019262 | N-acetylneuraminate catabolic process(GO:0019262) |
0.2 | 1.3 | GO:0050957 | equilibrioception(GO:0050957) |
0.2 | 0.8 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
0.2 | 0.5 | GO:0072554 | blood vessel lumenization(GO:0072554) negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588) |
0.2 | 1.5 | GO:0060136 | embryonic process involved in female pregnancy(GO:0060136) |
0.2 | 0.8 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
0.1 | 1.4 | GO:0019243 | methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727) |
0.1 | 0.7 | GO:0018242 | protein O-linked glycosylation via serine(GO:0018242) |
0.1 | 1.5 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
0.1 | 2.4 | GO:0030213 | hyaluronan biosynthetic process(GO:0030213) |
0.1 | 0.4 | GO:1904879 | positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879) |
0.1 | 2.0 | GO:0006699 | bile acid biosynthetic process(GO:0006699) |
0.1 | 0.3 | GO:0021506 | anterior neuropore closure(GO:0021506) neuropore closure(GO:0021995) |
0.1 | 0.4 | GO:0036500 | ATF6-mediated unfolded protein response(GO:0036500) |
0.1 | 3.2 | GO:0070306 | lens fiber cell differentiation(GO:0070306) |
0.1 | 1.8 | GO:0042759 | long-chain fatty acid biosynthetic process(GO:0042759) |
0.1 | 0.8 | GO:0008343 | adult feeding behavior(GO:0008343) |
0.1 | 1.3 | GO:0075522 | IRES-dependent viral translational initiation(GO:0075522) |
0.1 | 0.7 | GO:0050861 | positive regulation of B cell receptor signaling pathway(GO:0050861) |
0.1 | 2.3 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
0.1 | 0.8 | GO:0051533 | positive regulation of NFAT protein import into nucleus(GO:0051533) |
0.1 | 0.4 | GO:0001692 | histamine metabolic process(GO:0001692) histidine metabolic process(GO:0006547) imidazole-containing compound catabolic process(GO:0052805) |
0.1 | 0.9 | GO:0018026 | peptidyl-lysine monomethylation(GO:0018026) |
0.1 | 0.3 | GO:0090202 | transcriptional activation by promoter-enhancer looping(GO:0071733) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899) gene looping(GO:0090202) dsDNA loop formation(GO:0090579) |
0.1 | 3.5 | GO:0060236 | regulation of mitotic spindle organization(GO:0060236) |
0.1 | 1.3 | GO:0046697 | decidualization(GO:0046697) |
0.1 | 0.5 | GO:0051881 | regulation of mitochondrial membrane potential(GO:0051881) |
0.1 | 0.2 | GO:1904580 | regulation of intracellular mRNA localization(GO:1904580) |
0.1 | 0.3 | GO:0043686 | co-translational protein modification(GO:0043686) |
0.1 | 2.7 | GO:0043153 | entrainment of circadian clock by photoperiod(GO:0043153) |
0.1 | 0.5 | GO:0071630 | nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630) |
0.1 | 0.4 | GO:1903795 | regulation of inorganic anion transmembrane transport(GO:1903795) |
0.1 | 0.4 | GO:1903377 | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377) |
0.1 | 0.5 | GO:0006108 | malate metabolic process(GO:0006108) |
0.1 | 0.5 | GO:0000707 | meiotic DNA recombinase assembly(GO:0000707) |
0.1 | 0.4 | GO:0060576 | intestinal epithelial cell development(GO:0060576) |
0.1 | 0.3 | GO:0001887 | selenium compound metabolic process(GO:0001887) selenocysteine metabolic process(GO:0016259) |
0.1 | 0.6 | GO:0000056 | ribosomal small subunit export from nucleus(GO:0000056) |
0.1 | 0.7 | GO:0036123 | histone H3-K9 dimethylation(GO:0036123) |
0.1 | 1.0 | GO:0036010 | protein localization to endosome(GO:0036010) |
0.1 | 0.7 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
0.1 | 0.3 | GO:0097298 | regulation of nucleus size(GO:0097298) |
0.1 | 0.8 | GO:0060394 | negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394) |
0.1 | 0.7 | GO:0060539 | diaphragm development(GO:0060539) |
0.1 | 0.6 | GO:0033327 | Leydig cell differentiation(GO:0033327) |
0.1 | 0.6 | GO:0030388 | fructose 6-phosphate metabolic process(GO:0006002) fructose 1,6-bisphosphate metabolic process(GO:0030388) |
0.1 | 0.5 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
0.1 | 0.8 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
0.1 | 1.0 | GO:0006613 | cotranslational protein targeting to membrane(GO:0006613) |
0.1 | 0.2 | GO:1904684 | negative regulation of metalloendopeptidase activity(GO:1904684) |
0.1 | 0.5 | GO:1902416 | positive regulation of mRNA binding(GO:1902416) |
0.1 | 0.6 | GO:0006337 | nucleosome disassembly(GO:0006337) |
0.1 | 0.4 | GO:0033147 | positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606) negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147) |
0.1 | 0.7 | GO:0031639 | plasminogen activation(GO:0031639) |
0.0 | 0.1 | GO:0021577 | hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589) |
0.0 | 0.5 | GO:0006105 | succinate metabolic process(GO:0006105) |
0.0 | 0.8 | GO:0006491 | N-glycan processing(GO:0006491) |
0.0 | 0.1 | GO:0072086 | specification of loop of Henle identity(GO:0072086) |
0.0 | 1.4 | GO:0006739 | NADP metabolic process(GO:0006739) |
0.0 | 0.1 | GO:0050847 | progesterone receptor signaling pathway(GO:0050847) |
0.0 | 0.1 | GO:0060681 | branch elongation involved in ureteric bud branching(GO:0060681) |
0.0 | 0.3 | GO:0017196 | N-terminal peptidyl-methionine acetylation(GO:0017196) |
0.0 | 0.1 | GO:0060672 | negative regulation of keratinocyte differentiation(GO:0045617) epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672) |
0.0 | 0.2 | GO:0010961 | cellular magnesium ion homeostasis(GO:0010961) |
0.0 | 0.4 | GO:0031119 | tRNA pseudouridine synthesis(GO:0031119) |
0.0 | 0.1 | GO:1904207 | chemokine (C-C motif) ligand 2 secretion(GO:0035926) regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209) |
0.0 | 0.3 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
0.0 | 0.4 | GO:0045199 | maintenance of epithelial cell apical/basal polarity(GO:0045199) |
0.0 | 1.3 | GO:0048546 | digestive tract morphogenesis(GO:0048546) |
0.0 | 1.2 | GO:1904894 | positive regulation of JAK-STAT cascade(GO:0046427) positive regulation of STAT cascade(GO:1904894) |
0.0 | 3.9 | GO:0001843 | neural tube closure(GO:0001843) tube closure(GO:0060606) |
0.0 | 0.6 | GO:0010172 | embryonic body morphogenesis(GO:0010172) |
0.0 | 3.0 | GO:0001942 | hair follicle development(GO:0001942) |
0.0 | 2.9 | GO:0014066 | regulation of phosphatidylinositol 3-kinase signaling(GO:0014066) |
0.0 | 1.6 | GO:0021884 | forebrain neuron development(GO:0021884) |
0.0 | 1.3 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
0.0 | 0.0 | GO:0009794 | regulation of mitotic cell cycle, embryonic(GO:0009794) mitotic cell cycle, embryonic(GO:0045448) |
0.0 | 0.8 | GO:0001921 | positive regulation of receptor recycling(GO:0001921) |
0.0 | 0.8 | GO:0042755 | eating behavior(GO:0042755) |
0.0 | 0.2 | GO:0006573 | valine metabolic process(GO:0006573) |
0.0 | 0.1 | GO:0071455 | cellular response to hyperoxia(GO:0071455) |
0.0 | 0.3 | GO:0045475 | locomotor rhythm(GO:0045475) |
0.0 | 0.5 | GO:0006767 | water-soluble vitamin metabolic process(GO:0006767) |
0.0 | 7.9 | GO:0007015 | actin filament organization(GO:0007015) |
0.0 | 0.3 | GO:0046855 | inositol phosphate dephosphorylation(GO:0046855) |
0.0 | 1.5 | GO:0045638 | negative regulation of myeloid cell differentiation(GO:0045638) |
0.0 | 0.1 | GO:1903378 | positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378) |
0.0 | 2.9 | GO:0000910 | cytokinesis(GO:0000910) |
0.0 | 1.0 | GO:0030490 | maturation of SSU-rRNA(GO:0030490) |
0.0 | 0.2 | GO:0060218 | hematopoietic stem cell differentiation(GO:0060218) |
0.0 | 1.9 | GO:0030218 | erythrocyte differentiation(GO:0030218) |
0.0 | 0.2 | GO:0043518 | negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) |
0.0 | 0.5 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
0.0 | 0.1 | GO:0015862 | uridine transport(GO:0015862) |
0.0 | 2.2 | GO:0007219 | Notch signaling pathway(GO:0007219) |
0.0 | 0.1 | GO:0005513 | detection of calcium ion(GO:0005513) |
0.0 | 1.7 | GO:0000070 | mitotic sister chromatid segregation(GO:0000070) |
0.0 | 0.4 | GO:0006801 | superoxide metabolic process(GO:0006801) |
0.0 | 1.1 | GO:0006261 | DNA-dependent DNA replication(GO:0006261) |
0.0 | 0.4 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.8 | 8.9 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
1.5 | 13.9 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) |
1.2 | 3.7 | GO:0000801 | central element(GO:0000801) |
0.8 | 4.2 | GO:0005587 | collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651) |
0.8 | 10.2 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
0.6 | 1.8 | GO:0099573 | glutamatergic postsynaptic density(GO:0099573) |
0.6 | 1.7 | GO:0005588 | collagen type V trimer(GO:0005588) |
0.5 | 2.2 | GO:0008623 | CHRAC(GO:0008623) |
0.4 | 3.5 | GO:0072687 | meiotic spindle(GO:0072687) |
0.4 | 1.2 | GO:0045009 | melanosome membrane(GO:0033162) chitosome(GO:0045009) |
0.4 | 2.1 | GO:0031262 | Ndc80 complex(GO:0031262) |
0.3 | 1.6 | GO:0001674 | female germ cell nucleus(GO:0001674) |
0.2 | 1.2 | GO:1990357 | terminal web(GO:1990357) |
0.2 | 1.8 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
0.2 | 6.7 | GO:0016592 | mediator complex(GO:0016592) |
0.2 | 0.8 | GO:0071556 | integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553) |
0.1 | 0.6 | GO:0005945 | 6-phosphofructokinase complex(GO:0005945) |
0.1 | 0.7 | GO:0033553 | rDNA heterochromatin(GO:0033553) |
0.1 | 0.5 | GO:0045283 | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283) |
0.1 | 0.8 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) |
0.1 | 0.7 | GO:0005796 | Golgi lumen(GO:0005796) |
0.1 | 1.4 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
0.1 | 0.5 | GO:0033063 | Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063) |
0.1 | 0.4 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
0.1 | 0.9 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
0.1 | 1.1 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
0.1 | 0.5 | GO:0045261 | mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261) |
0.1 | 0.8 | GO:0005832 | chaperonin-containing T-complex(GO:0005832) |
0.1 | 0.5 | GO:0098799 | outer mitochondrial membrane protein complex(GO:0098799) |
0.1 | 0.4 | GO:0030015 | CCR4-NOT core complex(GO:0030015) |
0.1 | 0.6 | GO:0005642 | annulate lamellae(GO:0005642) |
0.1 | 0.7 | GO:0042405 | nuclear inclusion body(GO:0042405) |
0.0 | 0.2 | GO:0008091 | spectrin(GO:0008091) |
0.0 | 0.3 | GO:0097255 | R2TP complex(GO:0097255) |
0.0 | 1.8 | GO:0043209 | myelin sheath(GO:0043209) |
0.0 | 0.7 | GO:0042555 | MCM complex(GO:0042555) |
0.0 | 2.4 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
0.0 | 4.0 | GO:0016363 | nuclear matrix(GO:0016363) |
0.0 | 0.5 | GO:0046930 | pore complex(GO:0046930) |
0.0 | 1.5 | GO:0005719 | nuclear euchromatin(GO:0005719) |
0.0 | 13.9 | GO:0016607 | nuclear speck(GO:0016607) |
0.0 | 0.2 | GO:0071598 | neuronal ribonucleoprotein granule(GO:0071598) |
0.0 | 0.3 | GO:0031415 | NatA complex(GO:0031415) |
0.0 | 1.7 | GO:0045171 | intercellular bridge(GO:0045171) |
0.0 | 0.8 | GO:0031430 | M band(GO:0031430) |
0.0 | 2.8 | GO:0005604 | basement membrane(GO:0005604) |
0.0 | 1.7 | GO:0005871 | kinesin complex(GO:0005871) |
0.0 | 0.1 | GO:0033269 | internode region of axon(GO:0033269) |
0.0 | 0.5 | GO:0045120 | pronucleus(GO:0045120) |
0.0 | 0.5 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
0.0 | 0.2 | GO:0043219 | flotillin complex(GO:0016600) lateral loop(GO:0043219) |
0.0 | 0.8 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
0.0 | 2.0 | GO:0000922 | spindle pole(GO:0000922) |
0.0 | 0.7 | GO:0031526 | brush border membrane(GO:0031526) |
0.0 | 0.8 | GO:0030665 | clathrin-coated vesicle membrane(GO:0030665) |
0.0 | 0.1 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
0.0 | 2.4 | GO:0030496 | midbody(GO:0030496) |
0.0 | 0.3 | GO:0036038 | MKS complex(GO:0036038) |
0.0 | 7.0 | GO:0005667 | transcription factor complex(GO:0005667) |
0.0 | 3.5 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
0.0 | 0.3 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
0.0 | 0.8 | GO:0005643 | nuclear pore(GO:0005643) |
0.0 | 0.8 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
0.0 | 3.3 | GO:0016324 | apical plasma membrane(GO:0016324) |
0.0 | 0.5 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) large ribosomal subunit(GO:0015934) |
0.0 | 0.1 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
0.0 | 0.0 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
0.0 | 0.6 | GO:0000786 | nucleosome(GO:0000786) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.8 | 8.9 | GO:0030618 | transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618) |
0.7 | 14.1 | GO:0045295 | gamma-catenin binding(GO:0045295) |
0.6 | 4.1 | GO:0008568 | microtubule-severing ATPase activity(GO:0008568) |
0.5 | 13.1 | GO:0001222 | transcription corepressor binding(GO:0001222) |
0.5 | 1.6 | GO:0035939 | microsatellite binding(GO:0035939) |
0.4 | 1.3 | GO:0046538 | bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538) |
0.4 | 2.4 | GO:0043426 | MRF binding(GO:0043426) |
0.4 | 1.2 | GO:0035651 | AP-1 adaptor complex binding(GO:0035650) AP-3 adaptor complex binding(GO:0035651) |
0.4 | 1.5 | GO:0019808 | polyamine binding(GO:0019808) |
0.3 | 11.0 | GO:0008307 | structural constituent of muscle(GO:0008307) |
0.3 | 7.9 | GO:0008432 | JUN kinase binding(GO:0008432) |
0.3 | 1.1 | GO:0004921 | interleukin-11 receptor activity(GO:0004921) interleukin-11 binding(GO:0019970) |
0.3 | 0.8 | GO:0043183 | vascular endothelial growth factor receptor 1 binding(GO:0043183) |
0.2 | 1.9 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
0.2 | 1.3 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
0.2 | 1.3 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
0.2 | 0.8 | GO:0035515 | oxidative RNA demethylase activity(GO:0035515) |
0.2 | 1.3 | GO:0001515 | opioid peptide activity(GO:0001515) |
0.2 | 1.5 | GO:0070290 | N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290) |
0.2 | 1.8 | GO:0045294 | alpha-catenin binding(GO:0045294) |
0.2 | 2.3 | GO:0019855 | calcium channel inhibitor activity(GO:0019855) |
0.2 | 0.5 | GO:0008177 | succinate dehydrogenase (ubiquinone) activity(GO:0008177) 3 iron, 4 sulfur cluster binding(GO:0051538) |
0.2 | 1.4 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
0.2 | 0.5 | GO:0004473 | malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473) |
0.2 | 0.7 | GO:0016774 | phosphotransferase activity, carboxyl group as acceptor(GO:0016774) |
0.2 | 5.3 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
0.2 | 1.8 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
0.1 | 1.0 | GO:0016018 | cyclosporin A binding(GO:0016018) |
0.1 | 0.6 | GO:0003872 | 6-phosphofructokinase activity(GO:0003872) |
0.1 | 0.5 | GO:0003976 | UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976) |
0.1 | 0.5 | GO:0004427 | inorganic diphosphatase activity(GO:0004427) |
0.1 | 1.7 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
0.1 | 2.0 | GO:0036312 | phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312) |
0.1 | 0.4 | GO:0004784 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
0.1 | 1.6 | GO:0003680 | AT DNA binding(GO:0003680) |
0.1 | 0.9 | GO:0030976 | thiamine pyrophosphate binding(GO:0030976) |
0.1 | 0.8 | GO:0042500 | aspartic endopeptidase activity, intramembrane cleaving(GO:0042500) |
0.1 | 2.2 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
0.1 | 1.3 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
0.1 | 1.4 | GO:0070888 | E-box binding(GO:0070888) |
0.1 | 0.8 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
0.1 | 4.5 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
0.1 | 0.3 | GO:0004980 | melanocortin receptor activity(GO:0004977) melanocyte-stimulating hormone receptor activity(GO:0004980) |
0.1 | 1.1 | GO:0004576 | oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
0.1 | 1.8 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
0.1 | 0.2 | GO:0004616 | phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616) |
0.1 | 0.4 | GO:0004809 | tRNA (guanine-N2-)-methyltransferase activity(GO:0004809) |
0.1 | 6.3 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
0.1 | 1.5 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
0.1 | 0.5 | GO:0000150 | recombinase activity(GO:0000150) |
0.1 | 1.7 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
0.1 | 0.5 | GO:0097157 | pre-mRNA intronic binding(GO:0097157) |
0.1 | 8.2 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
0.1 | 2.6 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
0.1 | 8.2 | GO:0042826 | histone deacetylase binding(GO:0042826) |
0.1 | 3.2 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
0.1 | 1.1 | GO:0016857 | racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857) |
0.1 | 0.9 | GO:0018024 | histone-lysine N-methyltransferase activity(GO:0018024) |
0.1 | 0.6 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
0.1 | 0.3 | GO:0043141 | ATP-dependent 5'-3' DNA helicase activity(GO:0043141) |
0.1 | 1.0 | GO:0070300 | phosphatidic acid binding(GO:0070300) |
0.1 | 0.9 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
0.1 | 0.9 | GO:0035064 | methylated histone binding(GO:0035064) |
0.1 | 0.3 | GO:0042731 | PH domain binding(GO:0042731) |
0.1 | 1.3 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
0.0 | 2.0 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
0.0 | 0.7 | GO:0015197 | peptide transporter activity(GO:0015197) |
0.0 | 2.8 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
0.0 | 0.5 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
0.0 | 0.3 | GO:0019841 | retinol binding(GO:0019841) |
0.0 | 18.0 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
0.0 | 0.9 | GO:0030276 | clathrin binding(GO:0030276) |
0.0 | 0.1 | GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213) |
0.0 | 1.1 | GO:0003785 | actin monomer binding(GO:0003785) |
0.0 | 0.2 | GO:0071074 | eukaryotic initiation factor eIF2 binding(GO:0071074) |
0.0 | 0.7 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
0.0 | 0.6 | GO:0008253 | 5'-nucleotidase activity(GO:0008253) |
0.0 | 0.9 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
0.0 | 1.4 | GO:0050661 | NADP binding(GO:0050661) |
0.0 | 1.0 | GO:0008536 | Ran GTPase binding(GO:0008536) |
0.0 | 0.2 | GO:0034713 | type I transforming growth factor beta receptor binding(GO:0034713) |
0.0 | 0.2 | GO:0034452 | dynactin binding(GO:0034452) |
0.0 | 0.7 | GO:0050681 | androgen receptor binding(GO:0050681) |
0.0 | 1.9 | GO:0003777 | microtubule motor activity(GO:0003777) |
0.0 | 0.4 | GO:0009982 | pseudouridine synthase activity(GO:0009982) |
0.0 | 1.1 | GO:0032934 | cholesterol binding(GO:0015485) sterol binding(GO:0032934) |
0.0 | 0.6 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
0.0 | 0.5 | GO:0008276 | protein methyltransferase activity(GO:0008276) |
0.0 | 0.3 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
0.0 | 0.6 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
0.0 | 0.1 | GO:0008467 | [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467) |
0.0 | 0.2 | GO:0008484 | sulfuric ester hydrolase activity(GO:0008484) |
0.0 | 0.5 | GO:0005112 | Notch binding(GO:0005112) |
0.0 | 0.4 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
0.0 | 0.7 | GO:0070063 | RNA polymerase binding(GO:0070063) |
0.0 | 0.1 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
0.0 | 0.5 | GO:0005484 | SNAP receptor activity(GO:0005484) |
0.0 | 0.6 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
0.0 | 0.1 | GO:0044548 | S100 protein binding(GO:0044548) |
0.0 | 0.3 | GO:0031491 | nucleosome binding(GO:0031491) |
0.0 | 0.4 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
0.0 | 0.4 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
0.0 | 0.5 | GO:0016811 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811) |
0.0 | 1.6 | GO:0051015 | actin filament binding(GO:0051015) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 9.7 | PID_SMAD2_3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
0.2 | 14.2 | PID_AP1_PATHWAY | AP-1 transcription factor network |
0.2 | 7.2 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
0.1 | 2.8 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
0.1 | 8.8 | PID_PLK1_PATHWAY | PLK1 signaling events |
0.1 | 5.4 | PID_INTEGRIN3_PATHWAY | Beta3 integrin cell surface interactions |
0.1 | 6.9 | PID_HEDGEHOG_GLI_PATHWAY | Hedgehog signaling events mediated by Gli proteins |
0.1 | 0.7 | PID_TCR_JNK_PATHWAY | JNK signaling in the CD4+ TCR pathway |
0.1 | 1.8 | ST_WNT_CA2_CYCLIC_GMP_PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
0.1 | 6.4 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
0.1 | 2.5 | PID_ARF6_PATHWAY | Arf6 signaling events |
0.1 | 2.5 | PID_EPHRINB_REV_PATHWAY | Ephrin B reverse signaling |
0.1 | 2.2 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
0.0 | 2.3 | PID_NOTCH_PATHWAY | Notch signaling pathway |
0.0 | 3.9 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
0.0 | 1.4 | PID_HES_HEY_PATHWAY | Notch-mediated HES/HEY network |
0.0 | 1.1 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
0.0 | 0.6 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
0.0 | 0.6 | PID_ATM_PATHWAY | ATM pathway |
0.0 | 1.2 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
0.0 | 0.3 | PID_MYC_PATHWAY | C-MYC pathway |
0.0 | 0.7 | PID_ATR_PATHWAY | ATR signaling pathway |
0.0 | 0.4 | PID_PRL_SIGNALING_EVENTS_PATHWAY | Signaling events mediated by PRL |
0.0 | 0.9 | PID_P53_REGULATION_PATHWAY | p53 pathway |
0.0 | 0.3 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
0.0 | 0.6 | PID_EPHB_FWD_PATHWAY | EPHB forward signaling |
0.0 | 0.7 | PID_RB_1PATHWAY | Regulation of retinoblastoma protein |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 8.9 | REACTOME_SIGNALING_BY_NODAL | Genes involved in Signaling by NODAL |
0.4 | 10.2 | REACTOME_STRIATED_MUSCLE_CONTRACTION | Genes involved in Striated Muscle Contraction |
0.2 | 5.6 | REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT | Genes involved in Regulation of beta-cell development |
0.2 | 4.1 | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
0.1 | 5.5 | REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
0.1 | 5.3 | REACTOME_EGFR_DOWNREGULATION | Genes involved in EGFR downregulation |
0.1 | 3.9 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
0.1 | 2.5 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
0.1 | 5.9 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
0.1 | 1.5 | REACTOME_ACTIVATION_OF_RAC | Genes involved in Activation of Rac |
0.1 | 1.5 | REACTOME_METABOLISM_OF_POLYAMINES | Genes involved in Metabolism of polyamines |
0.1 | 3.8 | REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
0.1 | 2.0 | REACTOME_HS_GAG_DEGRADATION | Genes involved in HS-GAG degradation |
0.1 | 2.0 | REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
0.1 | 2.8 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
0.1 | 1.7 | REACTOME_KINESINS | Genes involved in Kinesins |
0.1 | 1.8 | REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
0.1 | 0.8 | REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
0.1 | 6.8 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
0.1 | 3.1 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
0.0 | 0.7 | REACTOME_UNWINDING_OF_DNA | Genes involved in Unwinding of DNA |
0.0 | 0.7 | REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS | Genes involved in Processing of Intronless Pre-mRNAs |
0.0 | 0.7 | REACTOME_SIGNALING_BY_PDGF | Genes involved in Signaling by PDGF |
0.0 | 0.6 | REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
0.0 | 0.2 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
0.0 | 1.1 | REACTOME_GLYCOLYSIS | Genes involved in Glycolysis |
0.0 | 0.5 | REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
0.0 | 0.9 | REACTOME_PEROXISOMAL_LIPID_METABOLISM | Genes involved in Peroxisomal lipid metabolism |
0.0 | 0.5 | REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
0.0 | 0.3 | REACTOME_ACTIVATION_OF_NF_KAPPAB_IN_B_CELLS | Genes involved in Activation of NF-kappaB in B Cells |
0.0 | 1.6 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
0.0 | 0.7 | REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS | Genes involved in O-linked glycosylation of mucins |
0.0 | 0.4 | REACTOME_DEADENYLATION_OF_MRNA | Genes involved in Deadenylation of mRNA |
0.0 | 1.8 | REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
0.0 | 0.9 | REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS | Genes involved in Integrin cell surface interactions |
0.0 | 0.3 | REACTOME_EXTENSION_OF_TELOMERES | Genes involved in Extension of Telomeres |
0.0 | 1.5 | REACTOME_MRNA_SPLICING | Genes involved in mRNA Splicing |
0.0 | 0.2 | REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
0.0 | 0.5 | REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION | Genes involved in PPARA Activates Gene Expression |
0.0 | 0.4 | REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
0.0 | 0.1 | REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION | Genes involved in FGFR4 ligand binding and activation |