Motif ID: Vsx2_Dlx3

Z-value: 1.292

Transcription factors associated with Vsx2_Dlx3:

Gene SymbolEntrez IDGene Name
Dlx3 ENSMUSG00000001510.7 Dlx3
Vsx2 ENSMUSG00000021239.6 Vsx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Vsx2mm10_v2_chr12_+_84569762_84569840-0.202.2e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Vsx2_Dlx3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_139543889 61.296 ENSMUST00000174792.1
ENSMUST00000031523.8
Uncx

UNC homeobox

chr6_-_23248264 38.300 ENSMUST00000031709.5
Fezf1
Fez family zinc finger 1
chr2_-_168767136 12.174 ENSMUST00000029061.5
ENSMUST00000103074.1
Sall4

sal-like 4 (Drosophila)

chr3_-_116253467 9.640 ENSMUST00000090473.5
Gpr88
G-protein coupled receptor 88
chr12_+_38780817 8.383 ENSMUST00000160856.1
Etv1
ets variant gene 1
chr12_+_38780284 7.755 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
Etv1


ets variant gene 1


chr3_+_55782500 7.718 ENSMUST00000075422.4
Mab21l1
mab-21-like 1 (C. elegans)
chr7_-_49636847 7.564 ENSMUST00000032717.6
Dbx1
developing brain homeobox 1
chr2_-_168767029 7.520 ENSMUST00000075044.3
Sall4
sal-like 4 (Drosophila)
chr10_+_73821857 7.505 ENSMUST00000177128.1
ENSMUST00000064562.7
ENSMUST00000129404.2
ENSMUST00000105426.3
ENSMUST00000131321.2
ENSMUST00000126920.2
ENSMUST00000147189.2
ENSMUST00000105424.3
ENSMUST00000092420.6
ENSMUST00000105429.3
ENSMUST00000131724.2
ENSMUST00000152655.2
ENSMUST00000151116.2
ENSMUST00000155701.2
ENSMUST00000152819.2
ENSMUST00000125517.2
ENSMUST00000124046.1
ENSMUST00000149977.2
ENSMUST00000146682.1
ENSMUST00000177107.1
Pcdh15



















protocadherin 15



















chr3_+_159839729 6.863 ENSMUST00000068952.5
Wls
wntless homolog (Drosophila)
chr9_-_79977782 6.224 ENSMUST00000093811.4
Filip1
filamin A interacting protein 1
chr10_-_6980376 6.091 ENSMUST00000105617.1
Ipcef1
interaction protein for cytohesin exchange factors 1
chr12_+_109545390 5.872 ENSMUST00000146701.1
Meg3
maternally expressed 3
chr17_-_70853482 5.456 ENSMUST00000118283.1
Tgif1
TGFB-induced factor homeobox 1
chr17_+_43952999 5.291 ENSMUST00000177857.1
Rcan2
regulator of calcineurin 2
chr12_-_31713873 5.228 ENSMUST00000057783.4
ENSMUST00000174480.2
ENSMUST00000176710.1
Gpr22


G protein-coupled receptor 22


chr14_-_48662740 4.600 ENSMUST00000122009.1
Otx2
orthodenticle homolog 2 (Drosophila)
chr1_+_109983737 4.527 ENSMUST00000172005.1
Cdh7
cadherin 7, type 2
chr3_-_154328634 4.449 ENSMUST00000167744.1
Lhx8
LIM homeobox protein 8
chr3_-_79841729 4.413 ENSMUST00000168038.1
Tmem144
transmembrane protein 144
chrX_-_60893430 4.310 ENSMUST00000135107.2
Sox3
SRY-box containing gene 3
chr8_-_57653023 4.018 ENSMUST00000034021.5
Galnt7
UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7
chr12_+_38781093 4.002 ENSMUST00000161513.1
Etv1
ets variant gene 1
chr4_+_62583568 3.781 ENSMUST00000098031.3
Rgs3
regulator of G-protein signaling 3
chr8_-_45382198 3.592 ENSMUST00000093526.6
Fam149a
family with sequence similarity 149, member A
chr16_-_42340595 3.349 ENSMUST00000102817.4
Gap43
growth associated protein 43
chr6_-_147264124 3.187 ENSMUST00000052296.6
Pthlh
parathyroid hormone-like peptide
chr8_-_61902669 3.092 ENSMUST00000121785.1
ENSMUST00000034057.7
Palld

palladin, cytoskeletal associated protein

chr12_-_56535047 3.078 ENSMUST00000178477.2
Nkx2-1
NK2 homeobox 1
chr4_+_8690399 3.047 ENSMUST00000127476.1
Chd7
chromodomain helicase DNA binding protein 7
chr1_-_79440039 3.031 ENSMUST00000049972.4
Scg2
secretogranin II
chr5_+_27261916 2.913 ENSMUST00000101471.3
Dpp6
dipeptidylpeptidase 6
chr14_-_12345847 2.819 ENSMUST00000022262.4
Fezf2
Fez family zinc finger 2
chr18_+_82914632 2.782 ENSMUST00000071233.6
Zfp516
zinc finger protein 516
chr9_+_119063429 2.658 ENSMUST00000141185.1
ENSMUST00000126251.1
ENSMUST00000136561.1
Vill


villin-like


chr5_-_98566762 2.649 ENSMUST00000086912.4
1700010H22Rik
RIKEN cDNA 1700010H22 gene
chr4_-_129261394 2.595 ENSMUST00000145261.1
C77080
expressed sequence C77080
chr10_+_128337761 2.478 ENSMUST00000005826.7
Cs
citrate synthase
chr3_-_88410295 2.468 ENSMUST00000056370.7
Pmf1
polyamine-modulated factor 1
chr9_+_75775355 2.446 ENSMUST00000012281.7
Bmp5
bone morphogenetic protein 5
chr1_-_175491130 2.300 ENSMUST00000027812.5
Rgs7
regulator of G protein signaling 7
chrM_+_7005 2.145 ENSMUST00000082405.1
mt-Co2
mitochondrially encoded cytochrome c oxidase II
chr4_-_132510493 2.122 ENSMUST00000030724.8
Sesn2
sestrin 2
chr13_-_102906046 2.100 ENSMUST00000171791.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr13_-_100616911 1.949 ENSMUST00000168772.1
ENSMUST00000163163.1
ENSMUST00000022137.7
Marveld2


MARVEL (membrane-associating) domain containing 2


chr5_-_138187177 1.869 ENSMUST00000110937.1
ENSMUST00000139276.1
ENSMUST00000048698.7
ENSMUST00000123415.1
Taf6



TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor



chr13_-_102905740 1.860 ENSMUST00000167462.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr1_-_78968079 1.837 ENSMUST00000049117.5
Gm5830
predicted pseudogene 5830
chr6_+_73248382 1.678 ENSMUST00000064740.6
Suclg1
succinate-CoA ligase, GDP-forming, alpha subunit
chr12_+_108605757 1.587 ENSMUST00000109854.2
Evl
Ena-vasodilator stimulated phosphoprotein
chr9_-_106891401 1.570 ENSMUST00000069036.7
Manf
mesencephalic astrocyte-derived neurotrophic factor
chr1_+_10993452 1.561 ENSMUST00000027056.5
Prex2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr7_+_144838590 1.538 ENSMUST00000105898.1
Fgf3
fibroblast growth factor 3
chr11_-_102185239 1.444 ENSMUST00000021297.5
Lsm12
LSM12 homolog (S. cerevisiae)
chr4_-_83285141 1.326 ENSMUST00000150522.1
Ttc39b
tetratricopeptide repeat domain 39B
chr17_-_70998010 1.279 ENSMUST00000024846.6
Myl12a
myosin, light chain 12A, regulatory, non-sarcomeric
chr14_-_122451109 1.238 ENSMUST00000081580.2
Gm5089
predicted gene 5089
chr2_-_121235689 1.227 ENSMUST00000142400.1
Trp53bp1
transformation related protein 53 binding protein 1
chr8_-_84846860 1.173 ENSMUST00000003912.6
Calr
calreticulin
chr2_+_49787675 1.155 ENSMUST00000028103.6
Lypd6b
LY6/PLAUR domain containing 6B
chr17_+_17402672 1.111 ENSMUST00000115576.2
Lix1
limb expression 1 homolog (chicken)
chr12_+_55598917 1.096 ENSMUST00000051857.3
Insm2
insulinoma-associated 2
chr5_+_138187485 1.090 ENSMUST00000110934.2
Cnpy4
canopy 4 homolog (zebrafish)
chr4_-_45532470 1.084 ENSMUST00000147448.1
Shb
src homology 2 domain-containing transforming protein B
chr18_-_75697639 1.072 ENSMUST00000165559.1
Ctif
CBP80/20-dependent translation initiation factor
chr16_-_89818338 1.066 ENSMUST00000164263.2
Tiam1
T cell lymphoma invasion and metastasis 1
chr9_+_53771499 1.063 ENSMUST00000048670.8
Slc35f2
solute carrier family 35, member F2
chr2_+_9882622 1.057 ENSMUST00000114919.1
4930412O13Rik
RIKEN cDNA 4930412O13 gene
chr3_-_50443603 0.930 ENSMUST00000029297.4
Slc7a11
solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
chr1_-_182282738 0.897 ENSMUST00000035295.5
Degs1
degenerative spermatocyte homolog 1 (Drosophila)
chr9_+_94669876 0.895 ENSMUST00000033463.9
Slc9a9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr7_-_116031047 0.882 ENSMUST00000106612.1
Sox6
SRY-box containing gene 6
chr1_-_172027269 0.869 ENSMUST00000027837.6
ENSMUST00000111264.1
Vangl2

vang-like 2 (van gogh, Drosophila)

chr11_-_102579461 0.861 ENSMUST00000107081.1
Gm11627
predicted gene 11627
chr9_-_71163224 0.822 ENSMUST00000074465.2
Aqp9
aquaporin 9
chr6_+_108065035 0.818 ENSMUST00000049246.6
Setmar
SET domain without mariner transposase fusion
chr5_+_88583527 0.792 ENSMUST00000031229.6
Rufy3
RUN and FYVE domain containing 3
chr4_+_5724304 0.757 ENSMUST00000108380.1
Fam110b
family with sequence similarity 110, member B
chr16_-_45724600 0.746 ENSMUST00000096057.4
Tagln3
transgelin 3
chr2_+_109917639 0.736 ENSMUST00000046548.7
ENSMUST00000111037.2
Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr4_-_110292719 0.727 ENSMUST00000106601.1
Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr1_-_172027251 0.714 ENSMUST00000138714.1
Vangl2
vang-like 2 (van gogh, Drosophila)
chr5_-_137531952 0.679 ENSMUST00000140139.1
Gnb2
guanine nucleotide binding protein (G protein), beta 2
chr12_+_52699297 0.662 ENSMUST00000095737.3
Akap6
A kinase (PRKA) anchor protein 6
chr9_-_21312255 0.621 ENSMUST00000115433.3
ENSMUST00000003397.7
Ap1m2

adaptor protein complex AP-1, mu 2 subunit

chr7_-_5014645 0.619 ENSMUST00000165320.1
Fiz1
Flt3 interacting zinc finger protein 1
chr4_+_99955715 0.600 ENSMUST00000102783.4
Pgm2
phosphoglucomutase 2
chr3_+_55461758 0.569 ENSMUST00000070418.4
Dclk1
doublecortin-like kinase 1
chr5_-_115652974 0.566 ENSMUST00000121746.1
ENSMUST00000118576.1
Ccdc64

coiled-coil domain containing 64

chr17_-_24073479 0.563 ENSMUST00000017090.5
Kctd5
potassium channel tetramerisation domain containing 5
chr11_-_33203588 0.499 ENSMUST00000037746.6
Tlx3
T cell leukemia, homeobox 3
chr11_+_94327984 0.485 ENSMUST00000107818.2
ENSMUST00000051221.6
Ankrd40

ankyrin repeat domain 40

chr1_+_87183310 0.468 ENSMUST00000044533.8
Prss56
protease, serine 56
chr17_-_35697971 0.468 ENSMUST00000146472.1
Ddr1
discoidin domain receptor family, member 1
chr18_-_66022580 0.466 ENSMUST00000143990.1
Lman1
lectin, mannose-binding, 1
chr1_-_84839304 0.457 ENSMUST00000027421.6
Trip12
thyroid hormone receptor interactor 12
chr2_-_69712461 0.418 ENSMUST00000102706.3
ENSMUST00000073152.6
Fastkd1

FAST kinase domains 1

chr7_-_115846080 0.410 ENSMUST00000166207.1
Sox6
SRY-box containing gene 6
chr3_+_122274371 0.406 ENSMUST00000035776.8
Dnttip2
deoxynucleotidyltransferase, terminal, interacting protein 2
chr4_-_14621669 0.376 ENSMUST00000143105.1
Slc26a7
solute carrier family 26, member 7
chr3_-_130730310 0.341 ENSMUST00000062601.7
Rpl34
ribosomal protein L34
chr16_+_34690548 0.302 ENSMUST00000023532.6
Ccdc14
coiled-coil domain containing 14
chr18_-_44662251 0.287 ENSMUST00000164666.1
Mcc
mutated in colorectal cancers
chr11_-_82890541 0.279 ENSMUST00000092844.6
ENSMUST00000021033.9
ENSMUST00000018985.8
Rad51d


RAD51 homolog D


chr3_-_130730375 0.251 ENSMUST00000079085.6
Rpl34
ribosomal protein L34
chrX_+_107255878 0.214 ENSMUST00000101294.2
ENSMUST00000118820.1
ENSMUST00000120971.1
Gpr174


G protein-coupled receptor 174


chr5_-_137531204 0.211 ENSMUST00000150063.2
Gnb2
guanine nucleotide binding protein (G protein), beta 2
chr6_+_63255971 0.194 ENSMUST00000159561.1
ENSMUST00000095852.3
Grid2

glutamate receptor, ionotropic, delta 2

chr1_+_66468364 0.192 ENSMUST00000061620.9
Unc80
unc-80 homolog (C. elegans)
chr10_-_53647080 0.191 ENSMUST00000169866.1
Fam184a
family with sequence similarity 184, member A
chr14_+_32321987 0.180 ENSMUST00000022480.7
Ogdhl
oxoglutarate dehydrogenase-like
chr4_-_41464816 0.167 ENSMUST00000108055.2
ENSMUST00000154535.1
ENSMUST00000030148.5
Kif24


kinesin family member 24


chr12_-_56613270 0.166 ENSMUST00000072631.5
Nkx2-9
NK2 homeobox 9
chr2_-_36136773 0.159 ENSMUST00000028251.3
Rbm18
RNA binding motif protein 18
chr2_-_71055534 0.137 ENSMUST00000090849.5
ENSMUST00000100037.2
ENSMUST00000112186.2
Mettl8


methyltransferase like 8


chr11_+_60537978 0.127 ENSMUST00000044250.3
Alkbh5
alkB, alkylation repair homolog 5 (E. coli)
chr11_-_102579071 0.117 ENSMUST00000107080.1
Gm11627
predicted gene 11627
chr10_+_127420867 0.116 ENSMUST00000064793.6
R3hdm2
R3H domain containing 2
chr16_-_92400067 0.104 ENSMUST00000023672.8
Rcan1
regulator of calcineurin 1
chr4_-_110286581 0.093 ENSMUST00000138972.1
Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr7_+_123123870 0.081 ENSMUST00000094053.5
Tnrc6a
trinucleotide repeat containing 6a
chr15_+_44428073 0.067 ENSMUST00000060652.3
Eny2
enhancer of yellow 2 homolog (Drosophila)
chr3_+_76593550 0.024 ENSMUST00000162471.1
Fstl5
follistatin-like 5

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
7.7 61.3 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
6.9 41.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
2.4 9.6 GO:0061743 motor learning(GO:0061743)
2.3 6.9 GO:0061357 Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) positive regulation of Wnt protein secretion(GO:0061357)
1.8 20.1 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
1.1 4.6 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
1.1 19.7 GO:0001833 inner cell mass cell proliferation(GO:0001833)
1.0 3.1 GO:0021759 globus pallidus development(GO:0021759)
1.0 3.0 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.9 7.5 GO:0050957 equilibrioception(GO:0050957)
0.7 2.1 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.6 2.4 GO:0021502 neural fold elevation formation(GO:0021502)
0.6 3.0 GO:0048245 eosinophil chemotaxis(GO:0048245)
0.5 1.6 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.5 1.6 GO:0002014 vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure(GO:0002014)
0.4 7.6 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.4 6.6 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.4 3.3 GO:0016198 axon choice point recognition(GO:0016198)
0.4 1.1 GO:1900149 positive regulation of Schwann cell migration(GO:1900149)
0.4 3.2 GO:0043129 surfactant homeostasis(GO:0043129)
0.3 4.4 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.3 5.4 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.3 1.6 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.2 0.7 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.2 5.9 GO:0008340 determination of adult lifespan(GO:0008340)
0.2 4.3 GO:0007530 sex determination(GO:0007530)
0.2 1.7 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.2 1.3 GO:0021780 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.2 0.7 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.2 2.5 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.2 3.1 GO:0071803 keratinocyte development(GO:0003334) positive regulation of podosome assembly(GO:0071803)
0.2 0.5 GO:1902915 negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.1 1.1 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.1 0.8 GO:0032782 bile acid secretion(GO:0032782)
0.1 0.9 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.1 0.9 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.1 4.0 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.1 1.2 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.1 0.6 GO:0019388 galactose catabolic process(GO:0019388)
0.1 2.8 GO:0050873 response to cold(GO:0009409) brown fat cell differentiation(GO:0050873)
0.1 1.5 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.1 2.7 GO:0051693 actin filament capping(GO:0051693)
0.1 0.8 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 1.9 GO:0061028 establishment of endothelial barrier(GO:0061028)
0.0 4.4 GO:0008585 female gonad development(GO:0008585)
0.0 0.3 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.0 2.9 GO:1903078 positive regulation of protein localization to plasma membrane(GO:1903078)
0.0 0.5 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.1 GO:0035553 oxidative single-stranded RNA demethylation(GO:0035553)
0.0 1.6 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.0 2.1 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 0.5 GO:0002087 regulation of respiratory gaseous exchange by neurological system process(GO:0002087)
0.0 1.1 GO:0097352 autophagosome maturation(GO:0097352)
0.0 1.1 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 0.2 GO:1904861 excitatory synapse assembly(GO:1904861)
0.0 2.3 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.0 4.8 GO:1901652 response to peptide(GO:1901652)
0.0 0.1 GO:0080009 mRNA methylation(GO:0080009)
0.0 0.2 GO:0006101 tricarboxylic acid cycle(GO:0006099) citrate metabolic process(GO:0006101)
0.0 0.3 GO:0071539 protein localization to centrosome(GO:0071539)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 4.4 GO:0001674 female germ cell nucleus(GO:0001674)
0.4 2.5 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.4 1.6 GO:0060187 cell pole(GO:0060187)
0.3 1.9 GO:0061689 paranodal junction(GO:0033010) tricellular tight junction(GO:0061689)
0.3 1.7 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.2 2.1 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.2 3.0 GO:0031045 dense core granule(GO:0031045)
0.2 1.1 GO:0060091 kinocilium(GO:0060091)
0.2 3.3 GO:0031527 filopodium membrane(GO:0031527)
0.2 6.9 GO:0032590 dendrite membrane(GO:0032590)
0.2 7.5 GO:0032420 stereocilium(GO:0032420)
0.2 2.1 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 1.2 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.1 19.7 GO:0000792 heterochromatin(GO:0000792)
0.1 2.3 GO:0044292 dendrite terminus(GO:0044292)
0.1 0.8 GO:0071437 invadopodium(GO:0071437)
0.1 1.9 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.1 3.1 GO:0002102 podosome(GO:0002102)
0.1 1.3 GO:0016460 myosin II complex(GO:0016460)
0.1 0.3 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.1 0.8 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.7 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 1.2 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.5 GO:0033655 host cell cytoplasm(GO:0030430) host cell cytoplasm part(GO:0033655)
0.0 0.3 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.2 GO:0045252 dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.6 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 123.8 GO:0005634 nucleus(GO:0005634)
0.0 0.8 GO:0016323 basolateral plasma membrane(GO:0016323)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 5.4 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.7 6.9 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.6 1.7 GO:0004774 succinate-CoA ligase activity(GO:0004774)
0.5 3.3 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.4 2.5 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.4 2.1 GO:0070728 leucine binding(GO:0070728)
0.3 3.2 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.3 0.9 GO:0042284 sphingolipid delta-4 desaturase activity(GO:0042284)
0.3 3.1 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.2 5.5 GO:0070410 co-SMAD binding(GO:0070410)
0.2 2.4 GO:0070700 BMP receptor binding(GO:0070700)
0.2 1.9 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.2 0.9 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.2 4.0 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.2 2.5 GO:0043522 leucine zipper domain binding(GO:0043522)
0.2 0.8 GO:0015254 glycerol channel activity(GO:0015254)
0.2 1.2 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.2 2.3 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.1 4.3 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 23.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 1.6 GO:0005522 profilin binding(GO:0005522)
0.1 0.9 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.1 4.4 GO:0015144 carbohydrate transmembrane transporter activity(GO:0015144) carbohydrate transporter activity(GO:1901476)
0.1 108.7 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.1 2.1 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.6 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.1 1.5 GO:0042056 chemoattractant activity(GO:0042056)
0.1 1.2 GO:0099602 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.1 1.5 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 2.2 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 13.0 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.1 7.7 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.1 8.2 GO:0047485 protein N-terminus binding(GO:0047485)
0.1 2.9 GO:0015459 potassium channel regulator activity(GO:0015459)
0.1 0.5 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 0.3 GO:0000150 recombinase activity(GO:0000150)
0.0 1.2 GO:0050681 androgen receptor binding(GO:0050681)
0.0 0.5 GO:0005537 mannose binding(GO:0005537)
0.0 0.5 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.0 0.1 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.0 0.8 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 0.2 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 0.9 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.9 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.8 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.6 GO:0097602 cullin family protein binding(GO:0097602)
0.0 1.6 GO:0008083 growth factor activity(GO:0008083)
0.0 1.3 GO:0035254 glutamate receptor binding(GO:0035254)
0.0 0.6 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 3.0 GO:0000287 magnesium ion binding(GO:0000287)
0.0 0.1 GO:0008174 mRNA methyltransferase activity(GO:0008174)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 20.1 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.2 6.1 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1 5.4 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 15.3 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 3.2 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 4.8 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 3.0 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.1 3.1 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 5.5 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 1.1 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 1.1 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.2 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.2 5.5 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 1.2 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 4.5 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 0.8 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 4.0 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.1 1.6 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules
0.0 4.1 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.6 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 1.9 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.6 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.9 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.0 2.5 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.9 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.5 REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION Genes involved in Transport to the Golgi and subsequent modification