Motif ID: Hoxd10

Z-value: 0.389


Transcription factors associated with Hoxd10:

Gene SymbolEntrez IDGene Name
Hoxd10 ENSMUSG00000050368.3 Hoxd10



Activity profile for motif Hoxd10.

activity profile for motif Hoxd10


Sorted Z-values histogram for motif Hoxd10

Sorted Z-values for motif Hoxd10



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxd10

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_27790947 4.404 ENSMUST00000115243.2
Opcml
opioid binding protein/cell adhesion molecule-like
chr3_-_80802789 2.876 ENSMUST00000107745.1
ENSMUST00000075316.4
Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr8_-_84773381 2.542 ENSMUST00000109764.1
Nfix
nuclear factor I/X
chr3_+_86084434 1.838 ENSMUST00000107664.2
Sh3d19
SH3 domain protein D19
chr7_+_96210107 1.790 ENSMUST00000138760.1
Tenm4
teneurin transmembrane protein 4
chr17_-_78684262 1.344 ENSMUST00000145480.1
Strn
striatin, calmodulin binding protein
chr15_+_9140527 1.225 ENSMUST00000090380.4
Lmbrd2
LMBR1 domain containing 2
chr10_+_69534039 1.156 ENSMUST00000182557.1
Ank3
ankyrin 3, epithelial
chrX_+_66653003 1.037 ENSMUST00000036043.4
Slitrk2
SLIT and NTRK-like family, member 2
chr2_+_65620829 0.948 ENSMUST00000028377.7
Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr4_+_102254993 0.880 ENSMUST00000106908.2
Pde4b
phosphodiesterase 4B, cAMP specific
chrX_-_70365052 0.855 ENSMUST00000101509.2
Ids
iduronate 2-sulfatase
chr15_+_25773985 0.771 ENSMUST00000125667.1
Myo10
myosin X
chr1_+_180111339 0.729 ENSMUST00000145181.1
Cdc42bpa
CDC42 binding protein kinase alpha
chr9_-_90255927 0.721 ENSMUST00000144646.1
Tbc1d2b
TBC1 domain family, member 2B
chr6_+_33249085 0.688 ENSMUST00000052266.8
ENSMUST00000090381.4
ENSMUST00000115080.1
Exoc4


exocyst complex component 4


chr9_+_95857597 0.631 ENSMUST00000034980.7
Atr
ataxia telangiectasia and Rad3 related
chr6_-_28397999 0.547 ENSMUST00000035930.4
Zfp800
zinc finger protein 800
chr7_+_30095150 0.539 ENSMUST00000130526.1
ENSMUST00000108200.1
Zfp260

zinc finger protein 260

chr15_+_57912199 0.500 ENSMUST00000022992.6
Tbc1d31
TBC1 domain family, member 31
chr17_-_46327949 0.498 ENSMUST00000047970.7
Abcc10
ATP-binding cassette, sub-family C (CFTR/MRP), member 10
chr3_+_55461758 0.476 ENSMUST00000070418.4
Dclk1
doublecortin-like kinase 1
chr1_-_152625212 0.391 ENSMUST00000027760.7
Rgl1
ral guanine nucleotide dissociation stimulator,-like 1
chr4_+_43401232 0.390 ENSMUST00000125399.1
Rusc2
RUN and SH3 domain containing 2
chr13_+_40917626 0.340 ENSMUST00000067778.6
Gcnt2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr7_-_73541738 0.325 ENSMUST00000169922.2
Chd2
chromodomain helicase DNA binding protein 2
chr1_-_45503282 0.294 ENSMUST00000086430.4
Col5a2
collagen, type V, alpha 2
chr5_+_121777929 0.292 ENSMUST00000160821.1
Atxn2
ataxin 2
chr17_+_78508063 0.255 ENSMUST00000024880.9
Vit
vitrin
chr2_+_21367532 0.245 ENSMUST00000055946.7
Gpr158
G protein-coupled receptor 158
chr18_-_78123324 0.213 ENSMUST00000160292.1
ENSMUST00000091813.5
Slc14a1

solute carrier family 14 (urea transporter), member 1

chr4_+_100478806 0.200 ENSMUST00000133493.2
ENSMUST00000092730.3
ENSMUST00000106979.3
Ube2u


ubiquitin-conjugating enzyme E2U (putative)


chr5_-_122697603 0.142 ENSMUST00000071235.4
Gm10064
predicted gene 10064
chr16_-_16560046 0.112 ENSMUST00000172181.2
Fgd4
FYVE, RhoGEF and PH domain containing 4
chr19_+_37436707 0.106 ENSMUST00000128184.1
Hhex
hematopoietically expressed homeobox
chrX_-_74246534 0.099 ENSMUST00000101454.2
ENSMUST00000033699.6
Flna

filamin, alpha

chr1_-_132390301 0.081 ENSMUST00000132435.1
Tmcc2
transmembrane and coiled-coil domains 2
chr18_-_6490808 0.034 ENSMUST00000028100.6
ENSMUST00000050542.5
Epc1

enhancer of polycomb homolog 1 (Drosophila)

chr9_-_45828618 0.007 ENSMUST00000117194.1
Cep164
centrosomal protein 164

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 GO:0032289 central nervous system myelin formation(GO:0032289) cardiac cell fate specification(GO:0060912)
0.2 0.6 GO:1904884 telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
0.1 2.5 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.1 1.2 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 0.3 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.1 2.9 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.1 0.7 GO:0048341 paraxial mesoderm formation(GO:0048341)
0.1 1.8 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 0.2 GO:0071918 urea transmembrane transport(GO:0071918)
0.1 0.3 GO:0036438 maintenance of lens transparency(GO:0036438)
0.1 0.9 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.1 GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
0.0 0.1 GO:0061010 gall bladder development(GO:0061010)
0.0 0.7 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.0 0.3 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 0.3 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.0 0.1 GO:0030035 microspike assembly(GO:0030035)
0.0 0.8 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.0 0.5 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.9 GO:0032279 asymmetric synapse(GO:0032279)
0.1 0.3 GO:0005588 collagen type V trimer(GO:0005588)
0.1 0.7 GO:0032584 growth cone membrane(GO:0032584)
0.1 1.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 1.2 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.9 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.2 GO:0033503 HULC complex(GO:0033503)
0.0 0.6 GO:0001741 XY body(GO:0001741)
0.0 0.1 GO:0031523 Myb complex(GO:0031523)
0.0 0.3 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.8 GO:0016459 myosin complex(GO:0016459)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.6 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 0.3 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.1 0.6 GO:0032405 MutLalpha complex binding(GO:0032405) MutSalpha complex binding(GO:0032407)
0.1 1.8 GO:0070064 proline-rich region binding(GO:0070064)
0.1 0.4 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 1.3 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 0.9 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.0 0.2 GO:0015265 urea channel activity(GO:0015265)
0.0 0.8 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 1.9 GO:0030507 spectrin binding(GO:0030507)
0.0 0.9 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.3 GO:0050692 DBD domain binding(GO:0050692)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.9 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 0.6 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 1.3 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling
0.0 0.8 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.7 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.9 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 0.6 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 0.9 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 1.2 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.7 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 1.8 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.9 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 0.8 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 0.2 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters