Motif ID: Lhx8

Z-value: 0.655


Transcription factors associated with Lhx8:

Gene SymbolEntrez IDGene Name
Lhx8 ENSMUSG00000096225.2 Lhx8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lhx8mm10_v2_chr3_-_154330543_154330576-0.333.7e-02Click!


Activity profile for motif Lhx8.

activity profile for motif Lhx8


Sorted Z-values histogram for motif Lhx8

Sorted Z-values for motif Lhx8



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx8

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_+_23415400 2.516 ENSMUST00000115832.2
ENSMUST00000047954.7
Dtna

dystrobrevin alpha

chr13_-_66851513 2.450 ENSMUST00000169322.1
Gm17404
predicted gene, 17404
chr7_+_91090697 2.438 ENSMUST00000107196.2
Dlg2
discs, large homolog 2 (Drosophila)
chr7_+_91090728 2.393 ENSMUST00000074273.3
Dlg2
discs, large homolog 2 (Drosophila)
chr2_+_65620829 2.374 ENSMUST00000028377.7
Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr3_-_73056943 2.364 ENSMUST00000059407.7
Slitrk3
SLIT and NTRK-like family, member 3
chr2_-_52558539 2.336 ENSMUST00000102760.3
ENSMUST00000102761.2
Cacnb4

calcium channel, voltage-dependent, beta 4 subunit

chr1_+_72284367 1.909 ENSMUST00000027380.5
ENSMUST00000141783.1
Tmem169

transmembrane protein 169

chr13_-_66852017 1.764 ENSMUST00000059329.6
Gm17449
predicted gene, 17449
chr15_+_21111452 1.745 ENSMUST00000075132.6
Cdh12
cadherin 12
chr13_-_66227573 1.687 ENSMUST00000167981.2
Gm10772
predicted gene 10772
chr5_+_137553517 1.669 ENSMUST00000136088.1
ENSMUST00000139395.1
ENSMUST00000136565.1
ENSMUST00000149292.1
ENSMUST00000125489.1
Actl6b




actin-like 6B




chr1_+_6487231 1.637 ENSMUST00000140079.1
ENSMUST00000131494.1
St18

suppression of tumorigenicity 18

chr8_+_34054622 1.608 ENSMUST00000149618.1
Gm9951
predicted gene 9951
chr2_-_114013619 1.431 ENSMUST00000090275.4
Gjd2
gap junction protein, delta 2
chr13_-_62466709 1.404 ENSMUST00000076195.5
Zfp935
zinc finger protein 935
chrX_+_101640056 1.404 ENSMUST00000119299.1
ENSMUST00000044475.4
Ogt

O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)

chr6_-_136173492 1.351 ENSMUST00000111905.1
Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr12_+_38783455 1.271 ENSMUST00000161980.1
ENSMUST00000160701.1
Etv1

ets variant gene 1

chr17_-_90088343 1.221 ENSMUST00000173917.1
Nrxn1
neurexin I
chr5_-_139129662 1.138 ENSMUST00000026973.7
Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr1_-_44218952 1.076 ENSMUST00000054801.3
Mettl21e
methyltransferase like 21E
chr1_+_33908172 1.064 ENSMUST00000182513.1
ENSMUST00000183034.1
Dst

dystonin

chr8_+_104831572 0.994 ENSMUST00000059449.6
Ces2b
carboxyesterase 2B
chr13_+_5861489 0.970 ENSMUST00000000080.6
Klf6
Kruppel-like factor 6
chr12_+_38783503 0.958 ENSMUST00000159334.1
Etv1
ets variant gene 1
chr10_-_4432285 0.946 ENSMUST00000155172.1
Rmnd1
required for meiotic nuclear division 1 homolog (S. cerevisiae)
chr18_-_43687695 0.926 ENSMUST00000082254.6
Jakmip2
janus kinase and microtubule interacting protein 2
chr4_-_155645408 0.886 ENSMUST00000115821.2
Gm10563
predicted gene 10563
chr1_-_127677923 0.874 ENSMUST00000160616.1
Tmem163
transmembrane protein 163
chr3_+_76075583 0.869 ENSMUST00000160261.1
Fstl5
follistatin-like 5
chr14_+_54625305 0.847 ENSMUST00000097177.4
Psmb11
proteasome (prosome, macropain) subunit, beta type, 11
chr18_+_12972225 0.816 ENSMUST00000025290.5
Impact
imprinted and ancient
chr8_+_45627709 0.802 ENSMUST00000134321.1
ENSMUST00000135336.1
Sorbs2

sorbin and SH3 domain containing 2

chr2_-_72986716 0.797 ENSMUST00000112062.1
Gm11084
predicted gene 11084
chr2_-_45110336 0.768 ENSMUST00000028229.6
ENSMUST00000152232.1
Zeb2

zinc finger E-box binding homeobox 2

chr8_+_110079758 0.758 ENSMUST00000058804.8
Zfp612
zinc finger protein 612
chr19_+_11469353 0.734 ENSMUST00000165310.1
Ms4a6c
membrane-spanning 4-domains, subfamily A, member 6C
chr2_-_67433181 0.727 ENSMUST00000180773.1
Gm26727
predicted gene, 26727
chr1_+_17145357 0.723 ENSMUST00000026879.7
Gdap1
ganglioside-induced differentiation-associated-protein 1
chr7_-_28372597 0.673 ENSMUST00000144700.1
Plekhg2
pleckstrin homology domain containing, family G (with RhoGef domain) member 2
chr10_-_4432312 0.649 ENSMUST00000126102.1
ENSMUST00000131853.1
ENSMUST00000042251.4
Rmnd1


required for meiotic nuclear division 1 homolog (S. cerevisiae)


chr18_+_37341702 0.622 ENSMUST00000053037.3
Pcdhb7
protocadherin beta 7
chr8_-_69373383 0.617 ENSMUST00000072427.4
Gm10033
predicted gene 10033
chr17_-_21908092 0.583 ENSMUST00000106026.2
2210404O09Rik
RIKEN cDNA 2210404O09 gene
chr15_-_99820072 0.581 ENSMUST00000109024.2
Lima1
LIM domain and actin binding 1
chr15_-_98221056 0.577 ENSMUST00000170618.1
ENSMUST00000141911.1
Olfr287

olfactory receptor 287

chr14_-_46831984 0.576 ENSMUST00000181311.1
ENSMUST00000074862.2
Gm10101

predicted gene 10101

chr4_+_126556994 0.560 ENSMUST00000147675.1
Clspn
claspin
chr5_-_76905463 0.544 ENSMUST00000146570.1
ENSMUST00000142450.1
ENSMUST00000120963.1
Aasdh


aminoadipate-semialdehyde dehydrogenase


chr1_-_74588117 0.523 ENSMUST00000066986.6
Zfp142
zinc finger protein 142
chr6_+_11926758 0.510 ENSMUST00000133776.1
Phf14
PHD finger protein 14
chr8_-_41054771 0.485 ENSMUST00000093534.4
Mtus1
mitochondrial tumor suppressor 1
chr13_+_62129894 0.472 ENSMUST00000099449.3
Zfp808
zinc finger protein 80
chr12_-_20900867 0.451 ENSMUST00000079237.5
Zfp125
zinc finger protein 125
chr16_+_24721842 0.442 ENSMUST00000115314.2
Lpp
LIM domain containing preferred translocation partner in lipoma
chr3_-_144760841 0.426 ENSMUST00000059091.5
Clca1
chloride channel calcium activated 1
chr17_-_24632608 0.423 ENSMUST00000097373.1
Tsc2
tuberous sclerosis 2
chr14_+_48446128 0.419 ENSMUST00000124720.1
Tmem260
transmembrane protein 260
chr11_+_110968016 0.413 ENSMUST00000106636.1
ENSMUST00000180023.1
Kcnj16

potassium inwardly-rectifying channel, subfamily J, member 16

chr1_-_170867761 0.411 ENSMUST00000027974.6
Atf6
activating transcription factor 6
chr2_-_175131864 0.408 ENSMUST00000108929.2
Gm14399
predicted gene 14399
chr7_-_28372494 0.398 ENSMUST00000119990.1
Plekhg2
pleckstrin homology domain containing, family G (with RhoGef domain) member 2
chr7_-_28372233 0.388 ENSMUST00000094644.4
Plekhg2
pleckstrin homology domain containing, family G (with RhoGef domain) member 2
chr3_-_116712696 0.388 ENSMUST00000169530.1
Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr5_-_76905390 0.371 ENSMUST00000135954.1
Aasdh
aminoadipate-semialdehyde dehydrogenase
chr10_+_58497918 0.360 ENSMUST00000036576.8
Ccdc138
coiled-coil domain containing 138
chr4_+_53011916 0.338 ENSMUST00000107665.3
Nipsnap3b
nipsnap homolog 3B (C. elegans)
chr10_-_67912620 0.325 ENSMUST00000064656.7
Zfp365
zinc finger protein 365
chr3_-_116712644 0.320 ENSMUST00000029569.2
Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr3_-_100685431 0.301 ENSMUST00000008907.7
Man1a2
mannosidase, alpha, class 1A, member 2
chrX_-_157415286 0.296 ENSMUST00000079945.4
ENSMUST00000138396.1
Phex

phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)

chr11_-_109995775 0.263 ENSMUST00000020948.8
Abca8b
ATP-binding cassette, sub-family A (ABC1), member 8b
chr1_-_172027251 0.257 ENSMUST00000138714.1
Vangl2
vang-like 2 (van gogh, Drosophila)
chr4_-_129121889 0.236 ENSMUST00000139450.1
ENSMUST00000125931.1
ENSMUST00000116444.2
Hpca


hippocalcin


chr11_+_44617310 0.227 ENSMUST00000081265.5
ENSMUST00000101326.3
ENSMUST00000109268.1
Ebf1


early B cell factor 1


chr3_-_53017195 0.215 ENSMUST00000036665.4
Cog6
component of oligomeric golgi complex 6
chr3_+_107291215 0.206 ENSMUST00000029502.7
Slc16a4
solute carrier family 16 (monocarboxylic acid transporters), member 4
chr7_+_12977834 0.195 ENSMUST00000108537.1
ENSMUST00000108535.1
ENSMUST00000045810.7
Zfp446


zinc finger protein 446


chr14_+_48446340 0.178 ENSMUST00000111735.2
Tmem260
transmembrane protein 260
chr16_-_16829276 0.171 ENSMUST00000023468.5
Spag6
sperm associated antigen 6
chr4_-_62502233 0.156 ENSMUST00000037820.2
Hdhd3
haloacid dehalogenase-like hydrolase domain containing 3
chr9_+_56994932 0.148 ENSMUST00000034832.6
Ptpn9
protein tyrosine phosphatase, non-receptor type 9
chr2_+_177508570 0.135 ENSMUST00000108940.2
Gm14403
predicted gene 14403
chr2_+_73312601 0.118 ENSMUST00000090811.4
ENSMUST00000112050.1
Scrn3

secernin 3

chr6_-_71440623 0.110 ENSMUST00000002292.8
Rmnd5a
required for meiotic nuclear division 5 homolog A (S. cerevisiae)
chr5_+_121795034 0.103 ENSMUST00000162327.1
Atxn2
ataxin 2
chr5_+_123930675 0.092 ENSMUST00000094320.3
ENSMUST00000165148.1
Ccdc62

coiled-coil domain containing 62

chr8_-_57652993 0.085 ENSMUST00000110316.2
Galnt7
UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7
chr2_+_112284561 0.082 ENSMUST00000053666.7
Slc12a6
solute carrier family 12, member 6
chr2_-_114175321 0.079 ENSMUST00000043160.6
Aqr
aquarius
chr5_+_34336289 0.061 ENSMUST00000182709.1
ENSMUST00000030992.6
Rnf4

ring finger protein 4

chr8_+_72219726 0.047 ENSMUST00000003123.8
Fam32a
family with sequence similarity 32, member A
chr1_+_161969179 0.030 ENSMUST00000111594.2
ENSMUST00000028021.6
Pigc

phosphatidylinositol glycan anchor biosynthesis, class C

chr4_+_126556935 0.025 ENSMUST00000048391.8
Clspn
claspin
chr7_-_60005101 0.015 ENSMUST00000059305.10
Snrpn
small nuclear ribonucleoprotein N
chr15_-_83595111 0.008 ENSMUST00000016901.3
Ttll12
tubulin tyrosine ligase-like family, member 12

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.3 4.8 GO:0045161 neuronal ion channel clustering(GO:0045161)
0.3 1.4 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.3 1.2 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.3 0.9 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.3 0.8 GO:0032058 positive regulation of translational initiation in response to stress(GO:0032058)
0.3 2.3 GO:0019227 neuronal action potential propagation(GO:0019227) detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962) action potential propagation(GO:0098870)
0.2 2.2 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.2 0.5 GO:0035790 platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790)
0.1 0.7 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.1 1.6 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.1 0.8 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.1 1.6 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.1 0.3 GO:0033566 gamma-tubulin complex localization(GO:0033566)
0.1 0.4 GO:0044861 protein transport into plasma membrane raft(GO:0044861)
0.1 1.1 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.1 0.2 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
0.1 0.6 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.0 0.8 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 1.1 GO:0008090 retrograde axonal transport(GO:0008090)
0.0 0.4 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.0 0.7 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 2.4 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 1.7 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.6 GO:0007608 sensory perception of smell(GO:0007608)
0.0 0.5 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.0 1.4 GO:0007601 visual perception(GO:0007601)
0.0 0.0 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.0 0.8 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.3 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.1 GO:0035826 rubidium ion transport(GO:0035826) cellular hypotonic response(GO:0071476)
0.0 0.6 GO:0030835 negative regulation of actin filament depolymerization(GO:0030835)
0.0 0.1 GO:0071394 cellular response to testosterone stimulus(GO:0071394)
0.0 0.4 GO:1902476 chloride transmembrane transport(GO:1902476)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:0031673 H zone(GO:0031673)
0.2 4.8 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 2.5 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 0.4 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.1 1.2 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 1.4 GO:0005922 connexon complex(GO:0005922)
0.1 1.8 GO:0042588 zymogen granule(GO:0042588)
0.1 1.4 GO:0043083 synaptic cleft(GO:0043083)
0.1 1.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 1.7 GO:0016514 SWI/SNF complex(GO:0016514)
0.1 2.3 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.9 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.8 GO:0005839 proteasome core complex(GO:0005839)
0.0 0.1 GO:0034657 GID complex(GO:0034657)
0.0 0.7 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.2 GO:0044327 dendritic spine head(GO:0044327)
0.0 0.3 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.2 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.9 GO:0005844 polysome(GO:0005844)
0.0 0.6 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.3 1.2 GO:0097109 neuroligin family protein binding(GO:0097109)
0.2 4.8 GO:0004385 guanylate kinase activity(GO:0004385)
0.2 1.4 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.2 2.3 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.2 0.9 GO:0004043 L-aminoadipate-semialdehyde dehydrogenase activity(GO:0004043)
0.1 1.1 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.1 0.6 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.1 0.6 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.4 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.8 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.3 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.7 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.0 0.4 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.8 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.6 GO:0003785 actin monomer binding(GO:0003785)
0.0 2.1 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.2 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.0 0.1 GO:0033142 progesterone receptor binding(GO:0033142)
0.0 1.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.1 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 0.4 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 0.8 GO:0043022 ribosome binding(GO:0043022)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.7 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.1 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.0 1.0 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 1.4 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 1.0 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.1 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.6 PID_ATR_PATHWAY ATR signaling pathway
0.0 0.4 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.1 1.4 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 1.1 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 1.7 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 2.3 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.4 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.4 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 1.5 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 0.7 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules