Motif ID: Nfe2l2

Z-value: 0.536


Transcription factors associated with Nfe2l2:

Gene SymbolEntrez IDGene Name
Nfe2l2 ENSMUSG00000015839.6 Nfe2l2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfe2l2mm10_v2_chr2_-_75704535_757046410.401.0e-02Click!


Activity profile for motif Nfe2l2.

activity profile for motif Nfe2l2


Sorted Z-values histogram for motif Nfe2l2

Sorted Z-values for motif Nfe2l2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfe2l2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_172219715 2.949 ENSMUST00000170700.1
ENSMUST00000003554.4
Casq1

calsequestrin 1

chr17_+_86963279 1.838 ENSMUST00000139344.1
Rhoq
ras homolog gene family, member Q
chr4_+_116685859 1.831 ENSMUST00000129315.1
ENSMUST00000106470.1
Prdx1

peroxiredoxin 1

chr4_+_116685544 1.751 ENSMUST00000135573.1
ENSMUST00000151129.1
Prdx1

peroxiredoxin 1

chr5_+_128601106 1.712 ENSMUST00000117102.2
Fzd10
frizzled homolog 10 (Drosophila)
chrX_-_52613913 1.710 ENSMUST00000069360.7
Gpc3
glypican 3
chr18_-_53418004 1.682 ENSMUST00000025419.7
Ppic
peptidylprolyl isomerase C
chr7_-_44997535 1.650 ENSMUST00000124232.1
ENSMUST00000003290.4
Bcl2l12

BCL2-like 12 (proline rich)

chr7_-_126799163 1.543 ENSMUST00000032934.5
Aldoa
aldolase A, fructose-bisphosphate
chr7_-_126799134 1.516 ENSMUST00000087566.4
Aldoa
aldolase A, fructose-bisphosphate
chrX_-_52613936 1.472 ENSMUST00000114857.1
Gpc3
glypican 3
chr3_+_131110350 1.402 ENSMUST00000066849.6
ENSMUST00000106341.2
ENSMUST00000029611.7
Lef1


lymphoid enhancer binding factor 1


chr1_+_165769392 1.210 ENSMUST00000040298.4
Creg1
cellular repressor of E1A-stimulated genes 1
chr7_-_44997221 1.188 ENSMUST00000152341.1
Bcl2l12
BCL2-like 12 (proline rich)
chr14_+_62292475 1.168 ENSMUST00000166879.1
Rnaseh2b
ribonuclease H2, subunit B
chr3_+_28805436 1.148 ENSMUST00000043867.5
Rpl22l1
ribosomal protein L22 like 1
chr11_-_109473598 1.111 ENSMUST00000070152.5
Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr7_-_105482197 1.101 ENSMUST00000047040.2
Prkcdbp
protein kinase C, delta binding protein
chr17_-_25570678 1.092 ENSMUST00000025003.3
ENSMUST00000173447.1
Sox8

SRY-box containing gene 8

chr2_+_180171485 1.076 ENSMUST00000061437.4
Adrm1
adhesion regulating molecule 1
chr17_-_47834682 1.072 ENSMUST00000066368.6
Mdfi
MyoD family inhibitor
chr4_-_126321669 1.070 ENSMUST00000102617.4
Adprhl2
ADP-ribosylhydrolase like 2
chr3_+_137623672 1.051 ENSMUST00000053855.7
Ddit4l
DNA-damage-inducible transcript 4-like
chr14_-_20393473 1.009 ENSMUST00000061444.3
Mrps16
mitochondrial ribosomal protein S16
chr7_-_102250086 0.981 ENSMUST00000106923.1
ENSMUST00000098230.4
Rhog

ras homolog gene family, member G

chr2_+_112261926 0.975 ENSMUST00000028553.3
Nop10
NOP10 ribonucleoprotein
chr3_-_141982224 0.953 ENSMUST00000029948.8
Bmpr1b
bone morphogenetic protein receptor, type 1B
chr17_-_25868727 0.943 ENSMUST00000026828.5
Fam195a
family with sequence similarity 195, member A
chr5_+_137758133 0.913 ENSMUST00000141733.1
ENSMUST00000110985.1
Tsc22d4

TSC22 domain family, member 4

chr10_+_17796256 0.867 ENSMUST00000037964.6
Txlnb
taxilin beta
chr1_+_136017967 0.864 ENSMUST00000063719.8
ENSMUST00000118832.1
Tmem9

transmembrane protein 9

chr16_+_90220742 0.853 ENSMUST00000023707.9
Sod1
superoxide dismutase 1, soluble
chr19_+_23675839 0.824 ENSMUST00000056396.5
Gm6563
predicted pseudogene 6563
chr10_-_34418465 0.822 ENSMUST00000099973.3
ENSMUST00000105512.1
ENSMUST00000047885.7
Nt5dc1


5'-nucleotidase domain containing 1


chr4_-_57956283 0.807 ENSMUST00000030051.5
Txn1
thioredoxin 1
chr1_+_136018062 0.807 ENSMUST00000117950.1
Tmem9
transmembrane protein 9
chr8_+_33653238 0.784 ENSMUST00000033992.8
Gsr
glutathione reductase
chr19_-_4037910 0.784 ENSMUST00000169613.1
Gstp1
glutathione S-transferase, pi 1
chr3_+_133338936 0.773 ENSMUST00000150386.1
ENSMUST00000125858.1
Ppa2

pyrophosphatase (inorganic) 2

chr5_-_53707532 0.766 ENSMUST00000031093.3
Cckar
cholecystokinin A receptor
chr17_-_70998010 0.746 ENSMUST00000024846.6
Myl12a
myosin, light chain 12A, regulatory, non-sarcomeric
chr2_-_25272380 0.728 ENSMUST00000028342.6
Ssna1
Sjogren's syndrome nuclear autoantigen 1
chr16_-_18811972 0.697 ENSMUST00000000028.7
ENSMUST00000115585.1
Cdc45

cell division cycle 45

chr12_-_85288419 0.668 ENSMUST00000121930.1
Acyp1
acylphosphatase 1, erythrocyte (common) type
chr5_-_100500592 0.620 ENSMUST00000149714.1
ENSMUST00000046154.5
Lin54

lin-54 homolog (C. elegans)

chr9_+_65214690 0.609 ENSMUST00000069000.7
Parp16
poly (ADP-ribose) polymerase family, member 16
chr7_+_28881656 0.607 ENSMUST00000066880.4
Capn12
calpain 12
chrX_+_159372175 0.604 ENSMUST00000087143.6
Eif1ax
eukaryotic translation initiation factor 1A, X-linked
chr12_+_55398775 0.598 ENSMUST00000021412.8
Psma6
proteasome (prosome, macropain) subunit, alpha type 6
chr9_+_66126611 0.581 ENSMUST00000034945.5
Fam96a
family with sequence similarity 96, member A
chr16_+_20548577 0.577 ENSMUST00000003319.5
Abcf3
ATP-binding cassette, sub-family F (GCN20), member 3
chr9_-_58313189 0.554 ENSMUST00000061799.8
Loxl1
lysyl oxidase-like 1
chr7_-_114276107 0.551 ENSMUST00000033008.9
Psma1
proteasome (prosome, macropain) subunit, alpha type 1
chr2_+_91054054 0.545 ENSMUST00000002171.7
ENSMUST00000111441.3
Psmc3

proteasome (prosome, macropain) 26S subunit, ATPase 3

chr14_+_26514554 0.543 ENSMUST00000104927.1
Gm2178
predicted gene 2178
chr11_-_30649510 0.535 ENSMUST00000074613.3
Acyp2
acylphosphatase 2, muscle type
chr5_+_100798627 0.527 ENSMUST00000016977.8
ENSMUST00000112898.1
ENSMUST00000112901.1
Mrps18c


mitochondrial ribosomal protein S18C


chr7_+_44468020 0.519 ENSMUST00000117324.1
ENSMUST00000120852.1
ENSMUST00000118628.1
Josd2


Josephin domain containing 2


chr2_+_91054009 0.515 ENSMUST00000067663.7
Psmc3
proteasome (prosome, macropain) 26S subunit, ATPase 3
chr11_+_78178105 0.510 ENSMUST00000147819.1
Tlcd1
TLC domain containing 1
chr12_+_80518990 0.510 ENSMUST00000021558.6
Galnt16
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 16
chr5_+_30013141 0.509 ENSMUST00000026845.7
Il6
interleukin 6
chr13_+_113342548 0.507 ENSMUST00000078163.7
BC067074
cDNA sequence BC067074
chr1_-_155146755 0.507 ENSMUST00000027744.8
Mr1
major histocompatibility complex, class I-related
chr14_-_54617993 0.499 ENSMUST00000022803.4
Psmb5
proteasome (prosome, macropain) subunit, beta type 5
chr18_+_61045139 0.493 ENSMUST00000025522.4
ENSMUST00000115274.1
Pdgfrb

platelet derived growth factor receptor, beta polypeptide

chr17_+_78491549 0.493 ENSMUST00000079363.4
Gm10093
predicted pseudogene 10093
chr18_+_61639542 0.486 ENSMUST00000183083.1
ENSMUST00000183087.1
Gm20748

predicted gene, 20748

chr2_+_153649442 0.480 ENSMUST00000072997.3
ENSMUST00000109773.1
ENSMUST00000109774.2
ENSMUST00000081628.6
ENSMUST00000103151.1
ENSMUST00000088976.5
ENSMUST00000109772.1
ENSMUST00000103150.3
ENSMUST00000056495.7
Dnmt3b








DNA methyltransferase 3B








chrX_-_38252398 0.479 ENSMUST00000089056.3
ENSMUST00000089054.4
ENSMUST00000066498.7
Tmem255a


transmembrane protein 255A


chr7_+_19083842 0.479 ENSMUST00000032568.7
ENSMUST00000122999.1
ENSMUST00000108473.3
ENSMUST00000108474.1
Dmpk



dystrophia myotonica-protein kinase



chr3_+_108256926 0.470 ENSMUST00000090569.5
Psma5
proteasome (prosome, macropain) subunit, alpha type 5
chr7_+_45639964 0.467 ENSMUST00000148532.1
Mamstr
MEF2 activating motif and SAP domain containing transcriptional regulator
chr13_+_14613242 0.467 ENSMUST00000170836.2
Psma2
proteasome (prosome, macropain) subunit, alpha type 2
chr11_+_78178651 0.467 ENSMUST00000092880.7
ENSMUST00000127587.1
ENSMUST00000108338.1
Tlcd1


TLC domain containing 1


chr2_-_181691771 0.464 ENSMUST00000108778.1
ENSMUST00000165416.1
Rgs19

regulator of G-protein signaling 19

chr11_+_60537978 0.451 ENSMUST00000044250.3
Alkbh5
alkB, alkylation repair homolog 5 (E. coli)
chr7_-_17056669 0.446 ENSMUST00000037762.4
Hif3a
hypoxia inducible factor 3, alpha subunit
chr6_-_8259098 0.443 ENSMUST00000012627.4
Rpa3
replication protein A3
chr7_-_29180699 0.443 ENSMUST00000059642.10
Psmd8
proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
chr17_-_45573253 0.425 ENSMUST00000165127.1
ENSMUST00000166469.1
ENSMUST00000024739.7
Hsp90ab1


heat shock protein 90 alpha (cytosolic), class B member 1


chr12_+_17544873 0.424 ENSMUST00000171737.1
Odc1
ornithine decarboxylase, structural 1
chr7_-_29180454 0.418 ENSMUST00000182328.1
Psmd8
proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
chr11_-_74723829 0.415 ENSMUST00000102520.2
Pafah1b1
platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
chr11_+_120673018 0.412 ENSMUST00000106158.2
ENSMUST00000103016.1
ENSMUST00000168714.1
Aspscr1


alveolar soft part sarcoma chromosome region, candidate 1 (human)


chr8_-_107588392 0.406 ENSMUST00000044106.4
Psmd7
proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
chr7_+_44468051 0.403 ENSMUST00000118493.1
Josd2
Josephin domain containing 2
chrX_+_164269371 0.398 ENSMUST00000145412.1
ENSMUST00000033749.7
Pir

pirin

chr9_+_86695542 0.393 ENSMUST00000150367.2
A330041J22Rik
RIKEN cDNA A330041J22 gene
chr19_-_4042165 0.386 ENSMUST00000042700.9
Gstp2
glutathione S-transferase, pi 2
chr8_+_105326354 0.384 ENSMUST00000015000.5
ENSMUST00000098453.2
Tmem208

transmembrane protein 208

chr17_+_34032348 0.376 ENSMUST00000173354.1
ENSMUST00000116612.2
Rxrb

retinoid X receptor beta

chr10_+_128058974 0.363 ENSMUST00000084771.2
Ptges3
prostaglandin E synthase 3 (cytosolic)
chr18_-_34954302 0.358 ENSMUST00000025217.8
Hspa9
heat shock protein 9
chr16_+_20651652 0.346 ENSMUST00000007212.8
Psmd2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
chr19_-_4839286 0.345 ENSMUST00000037246.5
Ccs
copper chaperone for superoxide dismutase
chr10_+_128058947 0.342 ENSMUST00000052798.7
Ptges3
prostaglandin E synthase 3 (cytosolic)
chr5_-_69592274 0.337 ENSMUST00000174233.1
ENSMUST00000120789.1
ENSMUST00000166298.1
Gnpda2


glucosamine-6-phosphate deaminase 2


chr2_-_130397525 0.331 ENSMUST00000028897.7
Cpxm1
carboxypeptidase X 1 (M14 family)
chr9_+_107578887 0.330 ENSMUST00000149638.1
ENSMUST00000139274.1
ENSMUST00000130053.1
ENSMUST00000122985.1
ENSMUST00000127380.1
ENSMUST00000139581.1
Nat6





N-acetyltransferase 6





chr12_-_40248073 0.318 ENSMUST00000169926.1
Ifrd1
interferon-related developmental regulator 1
chrX_-_167209149 0.316 ENSMUST00000112176.1
Tmsb4x
thymosin, beta 4, X chromosome
chr7_-_104315455 0.313 ENSMUST00000106837.1
ENSMUST00000106839.2
ENSMUST00000070943.6
Trim12a


tripartite motif-containing 12A


chr5_+_138187485 0.308 ENSMUST00000110934.2
Cnpy4
canopy 4 homolog (zebrafish)
chr11_-_50325599 0.306 ENSMUST00000179865.1
ENSMUST00000020637.8
Canx

calnexin

chr11_-_98438941 0.305 ENSMUST00000002655.7
Mien1
migration and invasion enhancer 1
chr11_+_107479549 0.297 ENSMUST00000106750.4
Psmd12
proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
chr4_-_140774196 0.295 ENSMUST00000026381.6
Padi4
peptidyl arginine deiminase, type IV
chr11_+_107479478 0.292 ENSMUST00000021063.6
ENSMUST00000106752.3
Psmd12

proteasome (prosome, macropain) 26S subunit, non-ATPase, 12

chr12_+_70974621 0.286 ENSMUST00000160027.1
ENSMUST00000160864.1
Psma3

proteasome (prosome, macropain) subunit, alpha type 3

chr2_+_120609383 0.285 ENSMUST00000124187.1
Haus2
HAUS augmin-like complex, subunit 2
chr7_+_127800604 0.276 ENSMUST00000046863.5
ENSMUST00000106272.1
ENSMUST00000139068.1
Hsd3b7


hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7


chr7_+_127800844 0.276 ENSMUST00000106271.1
ENSMUST00000138432.1
Hsd3b7

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7

chr4_+_130047840 0.276 ENSMUST00000044565.8
ENSMUST00000132251.1
Col16a1

collagen, type XVI, alpha 1

chr5_-_45450221 0.274 ENSMUST00000015950.5
Qdpr
quinoid dihydropteridine reductase
chr17_-_26939464 0.250 ENSMUST00000025027.8
ENSMUST00000114935.1
Cuta

cutA divalent cation tolerance homolog (E. coli)

chr18_+_35598607 0.243 ENSMUST00000041314.8
ENSMUST00000115737.1
ENSMUST00000115736.1
ENSMUST00000115735.1
Paip2



polyadenylate-binding protein-interacting protein 2



chr19_-_8929323 0.243 ENSMUST00000096242.3
Rom1
rod outer segment membrane protein 1
chr9_-_116175318 0.240 ENSMUST00000061101.4
ENSMUST00000035014.6
Tgfbr2

transforming growth factor, beta receptor II

chr15_+_80255184 0.239 ENSMUST00000109605.3
Atf4
activating transcription factor 4
chr7_+_141468776 0.238 ENSMUST00000058746.5
Cd151
CD151 antigen
chr19_+_8929628 0.234 ENSMUST00000096241.4
Eml3
echinoderm microtubule associated protein like 3
chr5_+_66676098 0.229 ENSMUST00000031131.9
Uchl1
ubiquitin carboxy-terminal hydrolase L1
chr8_+_106510853 0.228 ENSMUST00000080797.6
Cdh3
cadherin 3
chr16_+_58727910 0.227 ENSMUST00000023426.5
ENSMUST00000162057.1
ENSMUST00000162191.1
Cldn25


claudin 25


chr3_+_122245625 0.223 ENSMUST00000178826.1
Gclm
glutamate-cysteine ligase, modifier subunit
chr8_+_94984399 0.216 ENSMUST00000093271.6
Gpr56
G protein-coupled receptor 56
chr7_+_44848991 0.209 ENSMUST00000107885.1
Akt1s1
AKT1 substrate 1 (proline-rich)
chr6_-_129533267 0.208 ENSMUST00000181594.1
1700101I11Rik
RIKEN cDNA 1700101I11 gene
chr7_-_104353328 0.204 ENSMUST00000130139.1
ENSMUST00000059037.8
Trim12c

tripartite motif-containing 12C

chr8_+_69822429 0.203 ENSMUST00000164890.1
ENSMUST00000034325.4
Lpar2

lysophosphatidic acid receptor 2

chr5_+_31697960 0.194 ENSMUST00000114515.2
Bre
brain and reproductive organ-expressed protein
chr14_-_18239053 0.187 ENSMUST00000090543.5
Nr1d2
nuclear receptor subfamily 1, group D, member 2
chr18_+_73863672 0.175 ENSMUST00000134847.1
Mro
maestro
chr3_-_89402650 0.169 ENSMUST00000168325.1
ENSMUST00000057431.5
Lenep

lens epithelial protein

chrX_+_71050160 0.162 ENSMUST00000082088.3
ENSMUST00000114629.3
Mamld1

mastermind-like domain containing 1

chr1_-_120074023 0.158 ENSMUST00000056089.7
Tmem37
transmembrane protein 37
chr11_+_120673359 0.156 ENSMUST00000135346.1
ENSMUST00000127269.1
ENSMUST00000131727.2
ENSMUST00000149389.1
ENSMUST00000153346.1
Aspscr1




alveolar soft part sarcoma chromosome region, candidate 1 (human)




chr5_-_21785115 0.151 ENSMUST00000115193.1
ENSMUST00000115192.1
ENSMUST00000115195.1
ENSMUST00000030771.5
Dnajc2



DnaJ (Hsp40) homolog, subfamily C, member 2



chr5_+_31698050 0.145 ENSMUST00000114507.3
ENSMUST00000063813.4
ENSMUST00000071531.5
ENSMUST00000131995.1
Bre



brain and reproductive organ-expressed protein



chr2_-_120609319 0.139 ENSMUST00000102497.3
Lrrc57
leucine rich repeat containing 57
chr17_-_24644933 0.139 ENSMUST00000019684.5
Slc9a3r2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chr2_+_152105722 0.134 ENSMUST00000099225.2
Srxn1
sulfiredoxin 1 homolog (S. cerevisiae)
chr5_-_45450143 0.128 ENSMUST00000154962.1
Qdpr
quinoid dihydropteridine reductase
chr2_-_120609283 0.127 ENSMUST00000102496.1
Lrrc57
leucine rich repeat containing 57
chr4_+_117251951 0.125 ENSMUST00000062824.5
Tmem53
transmembrane protein 53
chr15_-_79834224 0.124 ENSMUST00000109623.1
ENSMUST00000109625.1
ENSMUST00000023060.6
ENSMUST00000089299.5
Cbx6

Npcd

chromobox 6

neuronal pentraxin chromo domain

chr15_-_79605084 0.105 ENSMUST00000023065.6
Dmc1
DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination
chr18_-_43477764 0.102 ENSMUST00000057110.9
Eif3j2
eukaryotic translation initiation factor 3, subunit J2
chr4_+_41569775 0.101 ENSMUST00000102963.3
Dnaic1
dynein, axonemal, intermediate chain 1
chr2_-_26910569 0.099 ENSMUST00000015920.5
ENSMUST00000139815.1
ENSMUST00000102899.3
Med22


mediator complex subunit 22


chr5_-_45450121 0.098 ENSMUST00000127562.1
Qdpr
quinoid dihydropteridine reductase
chr4_+_117252010 0.095 ENSMUST00000125943.1
ENSMUST00000106434.1
Tmem53

transmembrane protein 53

chr19_+_8839298 0.093 ENSMUST00000160556.1
Bscl2
Bernardinelli-Seip congenital lipodystrophy 2 homolog (human)
chr2_+_25272475 0.087 ENSMUST00000028341.4
Anapc2
anaphase promoting complex subunit 2
chr10_+_18845071 0.083 ENSMUST00000019998.7
Perp
PERP, TP53 apoptosis effector
chr2_-_163419508 0.072 ENSMUST00000046908.3
Oser1
oxidative stress responsive serine rich 1
chr16_-_17531019 0.057 ENSMUST00000142666.1
ENSMUST00000100125.3
Thap7

THAP domain containing 7

chr2_-_80581380 0.057 ENSMUST00000111760.2
Nckap1
NCK-associated protein 1
chr14_+_30825580 0.050 ENSMUST00000006701.5
Tmem110
transmembrane protein 110
chr19_-_6080311 0.043 ENSMUST00000159832.1
Vps51
vacuolar protein sorting 51 homolog (S. cerevisiae)
chr1_-_167285110 0.043 ENSMUST00000027839.8
Uck2
uridine-cytidine kinase 2
chr4_+_136357423 0.026 ENSMUST00000182167.1
Gm17388
predicted gene, 17388
chr3_+_122245557 0.025 ENSMUST00000029769.7
Gclm
glutamate-cysteine ligase, modifier subunit
chr5_-_138187177 0.020 ENSMUST00000110937.1
ENSMUST00000139276.1
ENSMUST00000048698.7
ENSMUST00000123415.1
Taf6



TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor



chr5_-_65428354 0.018 ENSMUST00000131263.1
Ugdh
UDP-glucose dehydrogenase
chr7_+_127912510 0.018 ENSMUST00000033070.7
Kat8
K(lysine) acetyltransferase 8
chr2_-_120609500 0.001 ENSMUST00000133612.1
ENSMUST00000102498.1
ENSMUST00000102499.1
Lrrc57


leucine rich repeat containing 57



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.2 GO:0072180 mesonephric duct development(GO:0072177) mesonephric duct morphogenesis(GO:0072180)
1.0 2.9 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.5 0.5 GO:0014722 regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
0.5 1.4 GO:0032696 negative regulation of interleukin-13 production(GO:0032696) trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) odontoblast differentiation(GO:0071895) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
0.4 1.1 GO:0072034 renal vesicle induction(GO:0072034)
0.3 3.1 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.3 2.8 GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166)
0.3 0.8 GO:0070488 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771) neutrophil aggregation(GO:0070488)
0.3 0.8 GO:0090274 positive regulation of somatostatin secretion(GO:0090274)
0.2 1.0 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.2 0.7 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) DNA replication preinitiation complex assembly(GO:0071163) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.2 1.7 GO:0038030 non-canonical Wnt signaling pathway via MAPK cascade(GO:0038030) non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.2 5.5 GO:0071451 cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451)
0.2 1.0 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
0.2 0.7 GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
0.2 1.1 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.2 0.5 GO:2000659 regulation of interleukin-1-mediated signaling pathway(GO:2000659)
0.2 0.5 GO:0035441 cell migration involved in vasculogenesis(GO:0035441) metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.2 0.5 GO:0060821 inactivation of X chromosome by DNA methylation(GO:0060821)
0.2 0.6 GO:0070213 protein auto-ADP-ribosylation(GO:0070213)
0.1 0.4 GO:0009446 putrescine biosynthetic process(GO:0009446)
0.1 0.8 GO:0046826 negative regulation of protein export from nucleus(GO:0046826)
0.1 0.4 GO:1902037 negative regulation of hematopoietic stem cell differentiation(GO:1902037)
0.1 0.5 GO:0035553 oxidative single-stranded RNA demethylation(GO:0035553)
0.1 0.9 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.1 0.4 GO:0006624 vacuolar protein processing(GO:0006624)
0.1 0.4 GO:0051661 maintenance of centrosome location(GO:0051661)
0.1 1.1 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.1 0.2 GO:0003274 endocardial cushion fusion(GO:0003274)
0.1 0.2 GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)
0.1 0.6 GO:0035754 B cell chemotaxis(GO:0035754)
0.1 0.6 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.1 0.2 GO:0051794 regulation of catagen(GO:0051794)
0.1 0.5 GO:0006729 tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
0.1 1.1 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
0.1 0.7 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.1 1.7 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 1.7 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.1 0.2 GO:0007412 axon target recognition(GO:0007412)
0.1 0.8 GO:0043248 proteasome assembly(GO:0043248)
0.1 1.2 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.0 0.3 GO:0019240 citrulline biosynthetic process(GO:0019240)
0.0 0.3 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0 0.2 GO:0051409 response to nitrosative stress(GO:0051409)
0.0 0.5 GO:0032620 interleukin-17 production(GO:0032620)
0.0 1.5 GO:0032543 mitochondrial translation(GO:0032543)
0.0 0.3 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.0 0.1 GO:0019062 virion attachment to host cell(GO:0019062) transforming growth factor beta activation(GO:0036363) adhesion of symbiont to host cell(GO:0044650) complement-dependent cytotoxicity(GO:0097278)
0.0 1.2 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.5 GO:0010831 positive regulation of myotube differentiation(GO:0010831)
0.0 0.4 GO:0006298 mismatch repair(GO:0006298)
0.0 0.2 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 0.3 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.0 1.1 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 0.2 GO:0045792 negative regulation of cell size(GO:0045792)
0.0 0.4 GO:0030224 monocyte differentiation(GO:0030224)
0.0 1.0 GO:1903078 positive regulation of protein localization to plasma membrane(GO:1903078)
0.0 0.2 GO:0060219 camera-type eye photoreceptor cell differentiation(GO:0060219)
0.0 0.4 GO:0055012 ventricular cardiac muscle cell differentiation(GO:0055012)
0.0 0.3 GO:0048671 negative regulation of collateral sprouting(GO:0048671)
0.0 0.0 GO:0009174 UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.0 0.1 GO:0008078 zygotic determination of anterior/posterior axis, embryo(GO:0007354) mesodermal cell migration(GO:0008078)
0.0 0.1 GO:0002934 desmosome organization(GO:0002934)
0.0 0.1 GO:0042148 strand invasion(GO:0042148)
0.0 0.2 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)
0.0 0.3 GO:0051353 positive regulation of oxidoreductase activity(GO:0051353)
0.0 0.8 GO:0051881 regulation of mitochondrial membrane potential(GO:0051881)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.9 GO:0014802 terminal cisterna(GO:0014802)
0.4 1.2 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.2 1.0 GO:0090661 box H/ACA telomerase RNP complex(GO:0090661)
0.2 2.4 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.2 0.7 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.2 2.5 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.2 3.1 GO:0035686 sperm fibrous sheath(GO:0035686)
0.2 1.2 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.2 0.5 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.1 3.6 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 1.1 GO:0031595 nuclear proteasome complex(GO:0031595)
0.1 1.4 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.1 0.3 GO:0031597 cytosolic proteasome complex(GO:0031597)
0.1 3.2 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 0.2 GO:0017109 glutamate-cysteine ligase complex(GO:0017109)
0.1 0.4 GO:0000235 astral microtubule(GO:0000235)
0.1 0.4 GO:0005838 proteasome regulatory particle(GO:0005838)
0.1 0.2 GO:1990590 ATF1-ATF4 transcription factor complex(GO:1990590)
0.1 0.9 GO:0031045 dense core granule(GO:0031045)
0.0 1.5 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.5 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.2 GO:1990462 omegasome(GO:1990462)
0.0 0.7 GO:0016460 myosin II complex(GO:0016460)
0.0 0.5 GO:0005839 proteasome core complex(GO:0005839)
0.0 0.3 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.0 0.3 GO:0070652 HAUS complex(GO:0070652)
0.0 0.7 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 0.6 GO:0098827 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.0 0.5 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.3 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.3 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.2 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.2 GO:0031931 TORC1 complex(GO:0031931)
0.0 1.1 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.1 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 0.1 GO:0036157 outer dynein arm(GO:0036157)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.1 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.4 3.6 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.3 1.2 GO:0003998 acylphosphatase activity(GO:0003998)
0.3 1.2 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.3 0.8 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.2 1.7 GO:0016018 cyclosporin A binding(GO:0016018)
0.2 1.4 GO:0030284 estrogen receptor activity(GO:0030284)
0.2 0.8 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.2 0.7 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.2 1.2 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.2 0.5 GO:0004155 6,7-dihydropteridine reductase activity(GO:0004155)
0.2 0.8 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.2 1.1 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.1 1.8 GO:0005522 profilin binding(GO:0005522)
0.1 1.0 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.1 2.9 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 3.2 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.1 1.1 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 0.5 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.1 1.0 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 0.5 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.1 0.6 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.1 0.2 GO:0004357 glutamate-cysteine ligase activity(GO:0004357)
0.1 0.2 GO:0005024 transforming growth factor beta-activated receptor activity(GO:0005024)
0.1 1.7 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 0.2 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.1 0.3 GO:0034618 arginine binding(GO:0034618)
0.1 0.3 GO:0004342 glucosamine-6-phosphate deaminase activity(GO:0004342)
0.1 0.5 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.1 0.5 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.1 0.2 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.1 0.8 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.1 1.2 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0 0.7 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.4 GO:0030375 thyroid hormone receptor coactivator activity(GO:0030375)
0.0 0.4 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0 0.6 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 2.8 GO:0002039 p53 binding(GO:0002039)
0.0 0.2 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.0 0.6 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 1.1 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 0.4 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.0 0.2 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 0.4 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 0.3 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.3 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.1 GO:0000150 recombinase activity(GO:0000150)
0.0 2.7 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.8 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.0 0.2 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.4 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 0.2 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.3 GO:0003785 actin monomer binding(GO:0003785)
0.0 1.1 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.0 0.1 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.0 1.1 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 0.5 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.1 GO:0002135 CTP binding(GO:0002135)
0.0 0.9 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.6 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.1 1.7 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.8 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 3.1 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.5 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.0 1.0 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.4 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 2.6 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.0 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.0 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 0.9 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 0.2 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.4 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 0.4 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.4 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.5 PID_ATF2_PATHWAY ATF-2 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.2 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.1 6.1 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1 3.1 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.1 0.6 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 0.4 REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0 0.4 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.7 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 1.0 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 0.8 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 1.0 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 1.0 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.8 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.3 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.2 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.6 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.0 0.4 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 1.4 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 1.5 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.5 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.0 0.2 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.6 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 1.8 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.1 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome