Motif ID: Nr1h2

Z-value: 1.149


Transcription factors associated with Nr1h2:

Gene SymbolEntrez IDGene Name
Nr1h2 ENSMUSG00000060601.6 Nr1h2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr1h2mm10_v2_chr7_-_44553901_445539550.533.6e-04Click!


Activity profile for motif Nr1h2.

activity profile for motif Nr1h2


Sorted Z-values histogram for motif Nr1h2

Sorted Z-values for motif Nr1h2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr1h2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_53159885 13.396 ENSMUST00000030010.3
Abca1
ATP-binding cassette, sub-family A (ABC1), member 1
chr7_-_97417730 8.882 ENSMUST00000043077.7
Thrsp
thyroid hormone responsive
chr10_-_109823585 7.765 ENSMUST00000161582.1
Nav3
neuron navigator 3
chr16_-_37384915 7.162 ENSMUST00000114787.1
ENSMUST00000114782.1
ENSMUST00000023526.2
ENSMUST00000114775.1
Stxbp5l



syntaxin binding protein 5-like



chr11_+_84179792 6.099 ENSMUST00000137500.2
ENSMUST00000130012.2
Acaca

acetyl-Coenzyme A carboxylase alpha

chr3_-_148989316 5.349 ENSMUST00000098518.2
Lphn2
latrophilin 2
chr5_-_124327883 5.015 ENSMUST00000031344.6
Mphosph9
M-phase phosphoprotein 9
chr11_+_84179852 4.961 ENSMUST00000136463.2
Acaca
acetyl-Coenzyme A carboxylase alpha
chr8_-_84773381 4.782 ENSMUST00000109764.1
Nfix
nuclear factor I/X
chr2_-_113829069 4.724 ENSMUST00000024005.7
Scg5
secretogranin V
chr16_-_37384940 4.712 ENSMUST00000114781.1
ENSMUST00000114780.1
Stxbp5l

syntaxin binding protein 5-like

chr13_-_12461432 4.329 ENSMUST00000143693.1
ENSMUST00000144283.1
ENSMUST00000099820.3
ENSMUST00000135166.1
Lgals8



lectin, galactose binding, soluble 8



chr13_+_44729794 4.280 ENSMUST00000172830.1
Jarid2
jumonji, AT rich interactive domain 2
chr3_+_62419668 4.226 ENSMUST00000161057.1
Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr5_+_76840597 3.708 ENSMUST00000120639.2
ENSMUST00000163347.1
ENSMUST00000121851.1
C530008M17Rik


RIKEN cDNA C530008M17 gene


chr11_-_60210410 3.625 ENSMUST00000144942.1
Srebf1
sterol regulatory element binding transcription factor 1
chr5_-_100159261 3.588 ENSMUST00000139520.1
Tmem150c
transmembrane protein 150C
chr2_+_102658640 3.526 ENSMUST00000080210.3
Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr15_+_79895017 3.493 ENSMUST00000023054.7
Apobec3
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3
chr7_+_114768736 2.998 ENSMUST00000117543.1
Insc
inscuteable homolog (Drosophila)
chr2_-_33087169 2.926 ENSMUST00000102810.3
Garnl3
GTPase activating RANGAP domain-like 3
chr18_+_37333853 2.921 ENSMUST00000061717.2
Pcdhb6
protocadherin beta 6
chr11_-_30025915 2.850 ENSMUST00000058902.5
Eml6
echinoderm microtubule associated protein like 6
chr7_-_27446599 2.782 ENSMUST00000011895.7
Sptbn4
spectrin beta, non-erythrocytic 4
chr2_+_155382186 2.777 ENSMUST00000134218.1
Trp53inp2
transformation related protein 53 inducible nuclear protein 2
chr4_-_141538562 2.381 ENSMUST00000105786.2
Spen
SPEN homolog, transcriptional regulator (Drosophila)
chr5_+_107331157 2.370 ENSMUST00000031215.8
ENSMUST00000112677.3
Brdt

bromodomain, testis-specific

chr5_+_123015010 2.357 ENSMUST00000121652.1
ENSMUST00000051016.4
Orai1

ORAI calcium release-activated calcium modulator 1

chr11_+_93996082 2.327 ENSMUST00000041956.7
Spag9
sperm associated antigen 9
chr5_-_136565432 2.321 ENSMUST00000176172.1
Cux1
cut-like homeobox 1
chr4_-_141538434 2.286 ENSMUST00000078886.3
Spen
SPEN homolog, transcriptional regulator (Drosophila)
chr7_-_80371197 2.246 ENSMUST00000098346.3
Man2a2
mannosidase 2, alpha 2
chr1_+_57377593 2.199 ENSMUST00000042734.2
1700066M21Rik
RIKEN cDNA 1700066M21 gene
chr1_+_58711488 2.115 ENSMUST00000097722.2
ENSMUST00000114313.1
Cflar

CASP8 and FADD-like apoptosis regulator

chr1_+_6214627 2.091 ENSMUST00000027040.6
Rb1cc1
RB1-inducible coiled-coil 1
chr11_-_102556122 2.066 ENSMUST00000143842.1
Gpatch8
G patch domain containing 8
chr8_-_36249292 2.046 ENSMUST00000065297.5
Lonrf1
LON peptidase N-terminal domain and ring finger 1
chr17_-_79715034 2.044 ENSMUST00000024894.1
Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
chr4_-_129440800 2.029 ENSMUST00000053042.5
ENSMUST00000106046.1
Zbtb8b

zinc finger and BTB domain containing 8b

chr2_+_30266721 2.011 ENSMUST00000113645.1
ENSMUST00000133877.1
ENSMUST00000139719.1
ENSMUST00000113643.1
ENSMUST00000150695.1
Phyhd1




phytanoyl-CoA dioxygenase domain containing 1




chr6_+_90462562 1.992 ENSMUST00000032174.5
Klf15
Kruppel-like factor 15
chr2_-_126876209 1.935 ENSMUST00000103224.3
Trpm7
transient receptor potential cation channel, subfamily M, member 7
chrX_-_102644210 1.919 ENSMUST00000052012.7
ENSMUST00000043596.5
ENSMUST00000119229.1
ENSMUST00000122022.1
ENSMUST00000120270.1
ENSMUST00000113611.2
Phka1





phosphorylase kinase alpha 1





chr7_+_81523531 1.907 ENSMUST00000181903.1
2900076A07Rik
RIKEN cDNA 2900076A07 gene
chr9_-_42472198 1.904 ENSMUST00000128959.1
ENSMUST00000066148.5
ENSMUST00000138506.1
Tbcel


tubulin folding cofactor E-like


chr7_+_81523555 1.842 ENSMUST00000180385.1
ENSMUST00000180879.1
ENSMUST00000181164.1
ENSMUST00000181264.1
2900076A07Rik



RIKEN cDNA 2900076A07 gene



chr15_+_65787023 1.822 ENSMUST00000015146.9
ENSMUST00000173858.1
ENSMUST00000172756.1
ENSMUST00000174856.1
Efr3a



EFR3 homolog A (S. cerevisiae)



chr2_+_158306493 1.814 ENSMUST00000016168.2
ENSMUST00000109491.1
Lbp

lipopolysaccharide binding protein

chr5_+_124194894 1.806 ENSMUST00000159053.1
ENSMUST00000162577.1
Gm16338

predicted gene 16338

chr2_+_156421083 1.691 ENSMUST00000125153.2
ENSMUST00000103136.1
ENSMUST00000109577.2
Epb4.1l1


erythrocyte protein band 4.1-like 1


chr16_+_13940630 1.656 ENSMUST00000141971.1
ENSMUST00000124947.1
ENSMUST00000023360.7
ENSMUST00000143697.1
Mpv17l



Mpv17 transgene, kidney disease mutant-like



chr17_-_25985641 1.613 ENSMUST00000041641.8
Capn15
calpain 15
chr5_-_120588613 1.484 ENSMUST00000046426.8
Tpcn1
two pore channel 1
chr1_-_164458345 1.383 ENSMUST00000027863.7
Atp1b1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr6_+_124663027 1.354 ENSMUST00000004381.7
Lpcat3
lysophosphatidylcholine acyltransferase 3
chr9_+_77941274 1.322 ENSMUST00000134072.1
Elovl5
ELOVL family member 5, elongation of long chain fatty acids (yeast)
chr15_+_85832301 1.270 ENSMUST00000146088.1
Ttc38
tetratricopeptide repeat domain 38
chr11_+_58963790 1.231 ENSMUST00000075141.6
Trim17
tripartite motif-containing 17
chr8_+_4238815 1.229 ENSMUST00000003027.7
ENSMUST00000110999.1
Map2k7

mitogen-activated protein kinase kinase 7

chr5_+_117363513 1.222 ENSMUST00000111959.1
Wsb2
WD repeat and SOCS box-containing 2
chr2_+_156420837 1.221 ENSMUST00000103137.3
Epb4.1l1
erythrocyte protein band 4.1-like 1
chr10_+_18845071 1.205 ENSMUST00000019998.7
Perp
PERP, TP53 apoptosis effector
chr2_+_156421048 1.167 ENSMUST00000109574.1
Epb4.1l1
erythrocyte protein band 4.1-like 1
chr2_+_131491764 1.136 ENSMUST00000028806.5
ENSMUST00000110179.2
ENSMUST00000110189.2
ENSMUST00000110182.2
ENSMUST00000110183.2
ENSMUST00000110186.2
ENSMUST00000110188.1
Smox






spermine oxidase






chr2_+_154548888 1.125 ENSMUST00000045116.4
ENSMUST00000109709.3
1700003F12Rik

RIKEN cDNA 1700003F12 gene

chr10_+_21993890 1.086 ENSMUST00000092673.4
Sgk1
serum/glucocorticoid regulated kinase 1
chr3_-_89245829 1.079 ENSMUST00000041022.8
Trim46
tripartite motif-containing 46
chr15_+_76879232 1.079 ENSMUST00000023179.5
Zfp7
zinc finger protein 7
chr6_-_134632388 1.063 ENSMUST00000047443.3
Mansc1
MANSC domain containing 1
chr5_+_103754154 1.049 ENSMUST00000054979.3
Aff1
AF4/FMR2 family, member 1
chr17_+_49428359 1.035 ENSMUST00000165390.2
ENSMUST00000024797.9
ENSMUST00000173033.1
Mocs1


molybdenum cofactor synthesis 1


chr2_+_155276297 1.003 ENSMUST00000029128.3
Map1lc3a
microtubule-associated protein 1 light chain 3 alpha
chr16_+_16870736 0.983 ENSMUST00000139740.1
ENSMUST00000119787.2
ENSMUST00000130650.1
ENSMUST00000156502.1
ENSMUST00000023465.7
ENSMUST00000124960.1
ENSMUST00000144513.1
Top3b






topoisomerase (DNA) III beta






chr12_+_87147703 0.963 ENSMUST00000063117.8
Gstz1
glutathione transferase zeta 1 (maleylacetoacetate isomerase)
chr12_-_87147883 0.956 ENSMUST00000037788.4
Pomt2
protein-O-mannosyltransferase 2
chr19_-_5845471 0.920 ENSMUST00000174287.1
ENSMUST00000173672.1
Neat1

nuclear paraspeckle assembly transcript 1 (non-protein coding)

chr2_+_155381808 0.915 ENSMUST00000043237.7
ENSMUST00000174685.1
Trp53inp2

transformation related protein 53 inducible nuclear protein 2

chr17_-_56716788 0.912 ENSMUST00000067931.5
Vmac
vimentin-type intermediate filament associated coiled-coil protein
chr2_+_61593125 0.911 ENSMUST00000112494.1
Tank
TRAF family member-associated Nf-kappa B activator
chrX_-_8175890 0.876 ENSMUST00000143984.1
Tbc1d25
TBC1 domain family, member 25
chr5_+_37185897 0.875 ENSMUST00000094840.3
Gm1043
predicted gene 1043
chr11_+_55098104 0.862 ENSMUST00000000608.7
Gm2a
GM2 ganglioside activator protein
chr16_+_16870829 0.851 ENSMUST00000131063.1
Top3b
topoisomerase (DNA) III beta
chr7_+_27862557 0.850 ENSMUST00000053722.8
Zfp607
zinc finger proten 607
chr4_+_123859651 0.822 ENSMUST00000097896.2
4933427I04Rik
Riken cDNA 4933427I04 gene
chr8_+_4238733 0.797 ENSMUST00000110998.2
ENSMUST00000062686.4
Map2k7

mitogen-activated protein kinase kinase 7

chr2_-_164911586 0.789 ENSMUST00000041361.7
Zfp335
zinc finger protein 335
chr13_+_55600055 0.788 ENSMUST00000133176.1
ENSMUST00000064701.6
B4galt7

xylosylprotein beta1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I)

chr2_+_30266513 0.779 ENSMUST00000091132.6
Phyhd1
phytanoyl-CoA dioxygenase domain containing 1
chr11_+_82952095 0.678 ENSMUST00000108158.2
ENSMUST00000067443.2
Slfn5

schlafen 5

chr5_+_124328083 0.670 ENSMUST00000111477.1
ENSMUST00000077376.2
2810006K23Rik

RIKEN cDNA 2810006K23 gene

chr4_-_44167580 0.657 ENSMUST00000098098.2
Rnf38
ring finger protein 38
chr4_+_43641262 0.642 ENSMUST00000123351.1
ENSMUST00000128549.1
Npr2

natriuretic peptide receptor 2

chr14_-_72602945 0.613 ENSMUST00000162825.1
Fndc3a
fibronectin type III domain containing 3A
chr1_+_135729147 0.607 ENSMUST00000027677.7
Csrp1
cysteine and glycine-rich protein 1
chr4_-_46389391 0.604 ENSMUST00000086563.4
ENSMUST00000030015.5
5830415F09Rik

RIKEN cDNA 5830415F09 gene

chr15_-_83251720 0.586 ENSMUST00000164614.1
ENSMUST00000049530.6
A4galt

alpha 1,4-galactosyltransferase

chr7_-_133776681 0.573 ENSMUST00000130182.1
ENSMUST00000106139.1
Dhx32

DEAH (Asp-Glu-Ala-His) box polypeptide 32

chr1_+_132506230 0.560 ENSMUST00000058167.1
Tmem81
transmembrane protein 81
chr3_+_90514435 0.550 ENSMUST00000048138.6
ENSMUST00000181271.1
S100a13

S100 calcium binding protein A13

chr11_-_101119889 0.547 ENSMUST00000017946.5
Fam134c
family with sequence similarity 134, member C
chr15_+_78877172 0.503 ENSMUST00000041587.7
Gga1
golgi associated, gamma adaptin ear containing, ARF binding protein 1
chr11_-_103697898 0.432 ENSMUST00000021329.7
Gosr2
golgi SNAP receptor complex member 2
chr11_-_101119814 0.424 ENSMUST00000107295.3
Fam134c
family with sequence similarity 134, member C
chr7_+_112953955 0.419 ENSMUST00000182858.1
Rassf10
Ras association (RalGDS/AF-6) domain family (N-terminal) member 10
chr10_-_81600857 0.396 ENSMUST00000151858.1
ENSMUST00000142948.1
ENSMUST00000072020.2
Tle6


transducin-like enhancer of split 6, homolog of Drosophila E(spl)


chr14_-_20730327 0.394 ENSMUST00000047490.5
Ndst2
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
chr11_-_69948145 0.390 ENSMUST00000179298.1
ENSMUST00000018710.6
ENSMUST00000135437.1
ENSMUST00000141837.2
ENSMUST00000142500.1
Slc2a4




solute carrier family 2 (facilitated glucose transporter), member 4




chr15_-_89425795 0.382 ENSMUST00000168376.1
Cpt1b
carnitine palmitoyltransferase 1b, muscle
chr4_-_152038568 0.369 ENSMUST00000030792.1
Tas1r1
taste receptor, type 1, member 1
chr2_+_61593077 0.366 ENSMUST00000112495.1
ENSMUST00000112501.2
Tank

TRAF family member-associated Nf-kappa B activator

chrX_-_155216338 0.364 ENSMUST00000112551.3
Sat1
spermidine/spermine N1-acetyl transferase 1
chr16_-_38550173 0.343 ENSMUST00000036210.6
Poglut1
protein O-glucosyltransferase 1
chr1_+_33719863 0.303 ENSMUST00000088287.3
Rab23
RAB23, member RAS oncogene family
chrX_-_155216444 0.302 ENSMUST00000026318.8
Sat1
spermidine/spermine N1-acetyl transferase 1
chr15_-_79328201 0.266 ENSMUST00000173163.1
ENSMUST00000047816.8
ENSMUST00000172403.2
ENSMUST00000173632.1
Pla2g6



phospholipase A2, group VI



chr15_-_79328154 0.262 ENSMUST00000166977.2
Pla2g6
phospholipase A2, group VI
chr9_+_37208291 0.213 ENSMUST00000034632.8
Tmem218
transmembrane protein 218
chr5_+_67306941 0.136 ENSMUST00000162372.1
ENSMUST00000113676.2
Slc30a9

solute carrier family 30 (zinc transporter), member 9

chr10_-_67548944 0.087 ENSMUST00000075686.4
Ado
2-aminoethanethiol (cysteamine) dioxygenase
chr16_+_96205719 0.076 ENSMUST00000129904.1
Sh3bgr
SH3-binding domain glutamic acid-rich protein
chr4_-_119422355 0.073 ENSMUST00000106316.1
ENSMUST00000030385.6
Ppcs

phosphopantothenoylcysteine synthetase

chr13_+_68582213 0.065 ENSMUST00000051784.8
Fastkd3
FAST kinase domains 3
chr8_+_18846251 0.051 ENSMUST00000149565.1
ENSMUST00000033847.4
Agpat5

1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)

chr5_-_136244865 0.034 ENSMUST00000005188.9
Sh2b2
SH2B adaptor protein 2
chr19_+_42247544 0.008 ENSMUST00000122375.1
Golga7b
golgi autoantigen, golgin subfamily a, 7B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 13.4 GO:0055099 response to high density lipoprotein particle(GO:0055099) platelet dense granule organization(GO:0060155)
2.8 11.1 GO:0044268 multicellular organismal protein metabolic process(GO:0044268)
0.7 4.3 GO:0002317 plasma cell differentiation(GO:0002317)
0.7 2.1 GO:0014891 striated muscle atrophy(GO:0014891)
0.7 2.0 GO:0071603 endothelial cell-cell adhesion(GO:0071603)
0.6 1.8 GO:0015920 lipopolysaccharide transport(GO:0015920)
0.6 3.5 GO:0032196 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196)
0.5 3.5 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.5 1.9 GO:0016340 calcium-dependent cell-matrix adhesion(GO:0016340)
0.5 2.8 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.5 12.5 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
0.5 1.4 GO:1903279 regulation of calcium:sodium antiporter activity(GO:1903279)
0.4 1.8 GO:0046208 spermine catabolic process(GO:0046208)
0.3 4.3 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.3 1.3 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.3 2.1 GO:0030242 pexophagy(GO:0030242)
0.3 2.3 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.3 1.7 GO:0010730 negative regulation of hydrogen peroxide metabolic process(GO:0010727) negative regulation of hydrogen peroxide biosynthetic process(GO:0010730)
0.3 0.5 GO:0050703 interleukin-1 alpha production(GO:0032610) interleukin-1 alpha secretion(GO:0050703)
0.3 4.8 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.2 2.2 GO:0006013 mannose metabolic process(GO:0006013)
0.2 11.9 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.2 1.0 GO:0006558 L-phenylalanine metabolic process(GO:0006558) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221)
0.2 4.7 GO:0016486 peptide hormone processing(GO:0016486)
0.2 1.8 GO:0006265 DNA topological change(GO:0006265)
0.2 4.2 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.2 1.0 GO:0006777 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720)
0.2 2.0 GO:2000671 regulation of motor neuron apoptotic process(GO:2000671)
0.2 1.2 GO:0002934 desmosome organization(GO:0002934)
0.2 2.4 GO:0007141 male meiosis I(GO:0007141)
0.2 0.5 GO:0090238 positive regulation of arachidonic acid secretion(GO:0090238)
0.2 0.9 GO:0006689 ganglioside catabolic process(GO:0006689) oligosaccharide catabolic process(GO:0009313)
0.2 0.7 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.1 1.0 GO:0060050 positive regulation of protein glycosylation(GO:0060050)
0.1 0.4 GO:0002002 regulation of angiotensin levels in blood(GO:0002002)
0.1 2.4 GO:0002115 store-operated calcium entry(GO:0002115)
0.1 1.3 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.1 0.6 GO:0001575 globoside metabolic process(GO:0001575)
0.1 2.0 GO:0072112 renal filtration cell differentiation(GO:0061318) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.1 1.0 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.1 0.9 GO:1901096 regulation of autophagosome maturation(GO:1901096)
0.1 2.9 GO:0009988 cell-cell recognition(GO:0009988)
0.1 1.1 GO:0006883 cellular sodium ion homeostasis(GO:0006883) glucocorticoid mediated signaling pathway(GO:0043402)
0.1 0.6 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.1 0.3 GO:0018242 protein O-linked glycosylation via serine(GO:0018242)
0.1 2.8 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.1 3.0 GO:0060487 lung epithelial cell differentiation(GO:0060487)
0.1 1.1 GO:0099612 protein localization to axon(GO:0099612)
0.1 5.2 GO:0010508 positive regulation of autophagy(GO:0010508)
0.0 0.8 GO:0080182 histone H3-K4 trimethylation(GO:0080182)
0.0 0.9 GO:0030575 nuclear body organization(GO:0030575)
0.0 0.4 GO:0050909 sensory perception of taste(GO:0050909)
0.0 0.4 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.0 0.6 GO:0060009 Sertoli cell development(GO:0060009)
0.0 0.4 GO:0044381 glucose import in response to insulin stimulus(GO:0044381)
0.0 0.3 GO:0006968 cellular defense response(GO:0006968)
0.0 0.8 GO:0048147 negative regulation of fibroblast proliferation(GO:0048147)
0.0 1.9 GO:0006073 glycogen metabolic process(GO:0005977) cellular glucan metabolic process(GO:0006073) glucan metabolic process(GO:0044042)
0.0 2.0 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.0 1.2 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 0.5 GO:1901998 toxin transport(GO:1901998)
0.0 3.7 GO:0000398 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 13.4 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.5 2.8 GO:0008091 spectrin(GO:0008091)
0.4 1.8 GO:0001533 cornified envelope(GO:0001533)
0.4 2.1 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.3 1.3 GO:0097447 dendritic tree(GO:0097447)
0.3 1.9 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.3 1.1 GO:1990769 proximal neuron projection(GO:1990769)
0.2 2.1 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.2 0.9 GO:0045098 type III intermediate filament(GO:0045098)
0.2 1.4 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.2 4.3 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 1.9 GO:0043196 varicosity(GO:0043196)
0.1 0.9 GO:0042382 paraspeckles(GO:0042382)
0.1 3.5 GO:0030673 axolemma(GO:0030673)
0.1 5.9 GO:0005776 autophagosome(GO:0005776)
0.1 2.3 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 8.4 GO:0001650 fibrillar center(GO:0001650)
0.0 4.7 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.6 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 2.9 GO:0005814 centriole(GO:0005814)
0.0 0.4 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 1.0 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.4 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 3.8 GO:0030141 secretory granule(GO:0030141)
0.0 6.9 GO:0005635 nuclear envelope(GO:0005635)
0.0 1.8 GO:0000793 condensed chromosome(GO:0000793)
0.0 0.8 GO:0035097 histone methyltransferase complex(GO:0035097)
0.0 0.5 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 5.2 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 2.4 GO:0030426 growth cone(GO:0030426)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.5 13.4 GO:0030226 apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
3.7 11.1 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.9 3.5 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.6 1.8 GO:0071723 lipopeptide binding(GO:0071723)
0.6 3.5 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.4 2.0 GO:0070330 aromatase activity(GO:0070330)
0.4 2.0 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.4 1.1 GO:0046592 polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)
0.4 1.5 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.4 1.8 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.3 1.3 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.3 1.9 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.2 2.1 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.2 1.4 GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.2 0.7 GO:0004145 diamine N-acetyltransferase activity(GO:0004145)
0.2 2.2 GO:0015924 mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.2 2.4 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.2 0.9 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.2 0.7 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.2 2.3 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.1 1.4 GO:0008556 sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556)
0.1 1.1 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.1 0.8 GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.1 0.6 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.1 1.0 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.1 0.4 GO:0008527 taste receptor activity(GO:0008527)
0.1 1.3 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.1 2.8 GO:0030506 ankyrin binding(GO:0030506)
0.1 0.3 GO:0030158 protein xylosyltransferase activity(GO:0030158)
0.1 11.9 GO:0019905 syntaxin binding(GO:0019905)
0.1 0.4 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.1 4.3 GO:0032452 histone demethylase activity(GO:0032452)
0.1 2.4 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 0.5 GO:0050786 RAGE receptor binding(GO:0050786)
0.1 1.6 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 0.5 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.1 0.4 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.1 0.9 GO:0019215 intermediate filament binding(GO:0019215)
0.1 3.6 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.1 0.4 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.1 0.5 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.0 2.0 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 2.8 GO:0051213 dioxygenase activity(GO:0051213)
0.0 0.5 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 0.6 GO:0015643 toxic substance binding(GO:0015643)
0.0 2.3 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 4.7 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.0 3.7 GO:0043130 ubiquitin binding(GO:0043130)
0.0 3.1 GO:0051082 unfolded protein binding(GO:0051082)
0.0 4.3 GO:0030674 protein binding, bridging(GO:0030674)
0.0 1.0 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 2.1 GO:0032947 protein complex scaffold(GO:0032947)
0.0 1.9 GO:0005262 calcium channel activity(GO:0005262)
0.0 1.0 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 2.2 GO:0005178 integrin binding(GO:0005178)
0.0 0.4 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 3.9 GO:0008017 microtubule binding(GO:0008017)
0.0 0.8 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 17.0 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.3 2.1 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1 2.0 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.1 3.8 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 2.7 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 2.4 PID_CD8_TCR_PATHWAY TCR signaling in naïve CD8+ T cells
0.0 4.3 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.8 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 2.7 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 0.7 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.2 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.4 PID_ARF_3PATHWAY Arf1 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 13.4 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.4 2.4 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.3 2.0 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.3 8.9 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.2 2.1 REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.2 1.4 REACTOME_ACYL_CHAIN_REMODELLING_OF_PS Genes involved in Acyl chain remodelling of PS
0.1 3.6 REACTOME_RORA_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in RORA Activates Circadian Expression
0.1 1.8 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.1 1.9 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 2.0 REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.1 0.5 REACTOME_ACYL_CHAIN_REMODELLING_OF_PE Genes involved in Acyl chain remodelling of PE
0.1 1.3 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 2.8 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 2.3 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.1 1.4 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.1 3.5 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 0.4 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.4 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.9 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.8 REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0 0.4 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 1.1 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.4 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis