Motif ID: Nfkb2

Z-value: 0.511


Transcription factors associated with Nfkb2:

Gene SymbolEntrez IDGene Name
Nfkb2 ENSMUSG00000025225.8 Nfkb2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfkb2mm10_v2_chr19_+_46305682_46305741-0.453.0e-03Click!


Activity profile for motif Nfkb2.

activity profile for motif Nfkb2


Sorted Z-values histogram for motif Nfkb2

Sorted Z-values for motif Nfkb2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfkb2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_74791516 3.638 ENSMUST00000006718.8
Wnt10a
wingless related MMTV integration site 10a
chr13_-_111490111 2.529 ENSMUST00000047627.7
Gpbp1
GC-rich promoter binding protein 1
chr13_-_111490028 2.460 ENSMUST00000091236.4
Gpbp1
GC-rich promoter binding protein 1
chrX_+_163908982 1.704 ENSMUST00000069041.8
Ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chrX_+_163909132 1.656 ENSMUST00000033734.7
ENSMUST00000112294.2
Ap1s2

adaptor-related protein complex 1, sigma 2 subunit

chr7_+_29289300 1.576 ENSMUST00000048187.4
Ppp1r14a
protein phosphatase 1, regulatory (inhibitor) subunit 14A
chr2_-_37422869 1.318 ENSMUST00000112936.1
ENSMUST00000112934.1
Rc3h2

ring finger and CCCH-type zinc finger domains 2

chr1_-_66817536 1.198 ENSMUST00000068168.3
ENSMUST00000113987.1
Kansl1l

KAT8 regulatory NSL complex subunit 1-like

chr11_-_84870712 1.186 ENSMUST00000170741.1
ENSMUST00000172405.1
ENSMUST00000100686.3
ENSMUST00000108081.2
Ggnbp2



gametogenetin binding protein 2



chr11_-_84870646 1.137 ENSMUST00000018547.2
Ggnbp2
gametogenetin binding protein 2
chr11_+_101176041 1.095 ENSMUST00000103109.3
Cntnap1
contactin associated protein-like 1
chr4_-_125127817 1.078 ENSMUST00000036188.7
Zc3h12a
zinc finger CCCH type containing 12A
chr11_-_84870812 0.852 ENSMUST00000168434.1
Ggnbp2
gametogenetin binding protein 2
chr11_+_70657687 0.759 ENSMUST00000134087.1
ENSMUST00000170716.1
Eno3

enolase 3, beta muscle

chr11_-_84870188 0.686 ENSMUST00000154915.2
Ggnbp2
gametogenetin binding protein 2
chr1_+_167001417 0.684 ENSMUST00000165874.1
Fam78b
family with sequence similarity 78, member B
chr14_+_80000292 0.679 ENSMUST00000088735.3
Olfm4
olfactomedin 4
chr9_+_55326913 0.666 ENSMUST00000085754.3
ENSMUST00000034862.4
AI118078

expressed sequence AI118078

chr2_-_32312162 0.637 ENSMUST00000155269.1
Dnm1
dynamin 1
chr7_+_16309577 0.625 ENSMUST00000002152.6
Bbc3
BCL2 binding component 3
chr19_+_6341121 0.612 ENSMUST00000025897.6
ENSMUST00000130382.1
Map4k2

mitogen-activated protein kinase kinase kinase kinase 2

chr14_-_30607808 0.601 ENSMUST00000112207.1
ENSMUST00000112206.1
ENSMUST00000112202.1
ENSMUST00000112203.1
Prkcd



protein kinase C, delta



chr2_-_77816758 0.561 ENSMUST00000111831.1
Zfp385b
zinc finger protein 385B
chr11_+_70657196 0.529 ENSMUST00000157027.1
ENSMUST00000072841.5
ENSMUST00000108548.1
ENSMUST00000126241.1
Eno3



enolase 3, beta muscle



chr3_+_97658212 0.525 ENSMUST00000045743.6
Prkab2
protein kinase, AMP-activated, beta 2 non-catalytic subunit
chr5_+_90891234 0.501 ENSMUST00000031327.8
Cxcl1
chemokine (C-X-C motif) ligand 1
chr10_+_80702649 0.497 ENSMUST00000095426.3
Izumo4
IZUMO family member 4
chr5_+_135887905 0.468 ENSMUST00000005077.6
Hspb1
heat shock protein 1
chr19_+_7268296 0.447 ENSMUST00000066646.4
Rcor2
REST corepressor 2
chr10_+_59221945 0.415 ENSMUST00000182161.1
Sowahc
sosondowah ankyrin repeat domain family member C
chr7_-_34654342 0.413 ENSMUST00000108069.1
Kctd15
potassium channel tetramerisation domain containing 15
chr14_-_55591077 0.412 ENSMUST00000161807.1
ENSMUST00000111378.3
ENSMUST00000159687.1
Psme2


proteasome (prosome, macropain) activator subunit 2 (PA28 beta)


chr2_-_3419019 0.396 ENSMUST00000115084.1
ENSMUST00000115083.1
Meig1

meiosis expressed gene 1

chr17_+_35379608 0.394 ENSMUST00000081435.4
H2-Q4
histocompatibility 2, Q region locus 4
chr11_+_77686155 0.377 ENSMUST00000100802.4
ENSMUST00000181023.1
Nufip2

nuclear fragile X mental retardation protein interacting protein 2

chr14_-_30626196 0.343 ENSMUST00000112210.3
ENSMUST00000112211.2
ENSMUST00000112208.1
Prkcd


protein kinase C, delta


chr11_-_54962903 0.331 ENSMUST00000108885.1
ENSMUST00000102730.2
ENSMUST00000018482.6
ENSMUST00000108886.1
ENSMUST00000102731.1
Tnip1




TNFAIP3 interacting protein 1




chr5_+_90759299 0.330 ENSMUST00000031318.4
Cxcl5
chemokine (C-X-C motif) ligand 5
chr5_+_110544326 0.328 ENSMUST00000040001.7
Galnt9
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9
chr5_+_135887988 0.327 ENSMUST00000111155.1
Hspb1
heat shock protein 1
chr2_-_3419066 0.308 ENSMUST00000115082.3
Meig1
meiosis expressed gene 1
chr1_-_63114516 0.303 ENSMUST00000097718.2
Ino80d
INO80 complex subunit D
chr10_-_89686250 0.301 ENSMUST00000092227.5
ENSMUST00000174252.1
Scyl2

SCY1-like 2 (S. cerevisiae)

chr1_+_135133272 0.298 ENSMUST00000167080.1
Ptpn7
protein tyrosine phosphatase, non-receptor type 7
chr3_-_116423930 0.298 ENSMUST00000106491.2
Cdc14a
CDC14 cell division cycle 14A
chr8_+_108714644 0.296 ENSMUST00000043896.8
Zfhx3
zinc finger homeobox 3
chr3_-_116424007 0.290 ENSMUST00000090464.4
Cdc14a
CDC14 cell division cycle 14A
chr5_+_37245792 0.288 ENSMUST00000031004.7
Crmp1
collapsin response mediator protein 1
chr1_+_135132693 0.279 ENSMUST00000049449.4
Ptpn7
protein tyrosine phosphatase, non-receptor type 7
chr17_+_35424842 0.275 ENSMUST00000174699.1
H2-Q6
histocompatibility 2, Q region locus 6
chr12_+_108792946 0.268 ENSMUST00000021692.7
Yy1
YY1 transcription factor
chr11_-_70015346 0.260 ENSMUST00000018718.7
ENSMUST00000102574.3
Acadvl

acyl-Coenzyme A dehydrogenase, very long chain

chr4_-_42168603 0.258 ENSMUST00000098121.3
Gm13305
predicted gene 13305
chr17_+_35866056 0.243 ENSMUST00000122899.1
Ppp1r18
protein phosphatase 1, regulatory subunit 18
chr2_+_102550012 0.233 ENSMUST00000028612.7
Pamr1
peptidase domain containing associated with muscle regeneration 1
chr17_+_35262730 0.182 ENSMUST00000172785.1
H2-D1
histocompatibility 2, D region locus 1
chr2_+_10153563 0.162 ENSMUST00000026886.7
Itih5
inter-alpha (globulin) inhibitor H5
chr19_-_46338632 0.149 ENSMUST00000051234.8
ENSMUST00000167861.1
Cuedc2

CUE domain containing 2

chr2_-_102451792 0.146 ENSMUST00000099678.3
Fjx1
four jointed box 1 (Drosophila)
chr1_+_34801704 0.136 ENSMUST00000047664.9
Arhgef4
Rho guanine nucleotide exchange factor (GEF) 4
chr1_-_63114255 0.124 ENSMUST00000153992.1
ENSMUST00000165066.1
ENSMUST00000172416.1
ENSMUST00000137511.1
Ino80d



INO80 complex subunit D



chr17_-_34287770 0.113 ENSMUST00000174751.1
ENSMUST00000040655.6
H2-Aa

histocompatibility 2, class II antigen A, alpha

chr13_+_43785107 0.102 ENSMUST00000015540.2
Cd83
CD83 antigen
chr1_+_167001457 0.096 ENSMUST00000126198.1
Fam78b
family with sequence similarity 78, member B
chr5_-_137531204 0.095 ENSMUST00000150063.2
Gnb2
guanine nucleotide binding protein (G protein), beta 2
chr1_+_153740344 0.079 ENSMUST00000027748.7
Rgs16
regulator of G-protein signaling 16
chr17_+_35866606 0.063 ENSMUST00000113814.4
Ppp1r18
protein phosphatase 1, regulatory subunit 18
chr5_-_137530990 0.046 ENSMUST00000132525.1
Gnb2
guanine nucleotide binding protein (G protein), beta 2
chr17_+_35979851 0.045 ENSMUST00000087200.3
Gnl1
guanine nucleotide binding protein-like 1
chr11_-_33147400 0.028 ENSMUST00000020507.7
Fgf18
fibroblast growth factor 18
chr7_+_3290553 0.023 ENSMUST00000096744.5
Myadm
myeloid-associated differentiation marker
chr11_-_70656467 0.008 ENSMUST00000131642.1
Gm12319
predicted gene 12319
chr17_+_34898931 0.005 ENSMUST00000097342.3
ENSMUST00000013931.5
Ehmt2

euchromatic histone lysine N-methyltransferase 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.9 GO:0033140 negative regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033140)
0.4 1.1 GO:0050713 negative regulation of interleukin-1 beta secretion(GO:0050713) negative regulation of interferon-gamma secretion(GO:1902714) response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869)
0.3 1.1 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.2 2.6 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.2 0.8 GO:0070942 neutrophil mediated cytotoxicity(GO:0070942) neutrophil mediated killing of symbiont cell(GO:0070943)
0.2 0.9 GO:0006680 glucosylceramide catabolic process(GO:0006680)
0.2 0.6 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.1 0.8 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
0.1 1.3 GO:0061470 T follicular helper cell differentiation(GO:0061470)
0.1 0.3 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.1 0.6 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.1 0.3 GO:0071707 immunoglobulin heavy chain V-D-J recombination(GO:0071707)
0.1 0.3 GO:1904529 regulation of actin filament binding(GO:1904529) regulation of actin binding(GO:1904616)
0.1 3.4 GO:0060612 adipose tissue development(GO:0060612)
0.1 0.6 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 0.3 GO:1903003 positive regulation of protein deubiquitination(GO:1903003)
0.0 0.2 GO:0002484 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway(GO:0002484) antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent(GO:0002485)
0.0 0.3 GO:2000286 receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
0.0 0.1 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.0 0.3 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.0 0.7 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.0 1.6 GO:0035690 cellular response to drug(GO:0035690)
0.0 0.6 GO:0006903 vesicle targeting(GO:0006903)
0.0 0.5 GO:0019884 antigen processing and presentation of exogenous antigen(GO:0019884)
0.0 0.1 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)
0.0 0.7 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 1.3 GO:0006096 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.1 1.3 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 0.8 GO:0097512 cardiac myofibril(GO:0097512)
0.1 0.9 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.7 GO:0042581 specific granule(GO:0042581)
0.0 1.1 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.5 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.6 GO:0043196 varicosity(GO:0043196)
0.0 3.4 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 0.4 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.3 GO:0031011 Ino80 complex(GO:0031011)
0.0 0.1 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 1.2 GO:0000123 histone acetyltransferase complex(GO:0000123)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0070976 calcium-independent protein kinase C activity(GO:0004699) TIR domain binding(GO:0070976)
0.1 1.3 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 3.6 GO:0005109 frizzled binding(GO:0005109)
0.1 0.3 GO:0017099 very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099)
0.1 1.1 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 0.8 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.1 0.9 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.1 0.6 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.1 0.5 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.0 0.4 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.6 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 1.6 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.8 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.3 GO:0031005 filamin binding(GO:0031005)
0.0 1.6 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.6 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.3 GO:0000400 four-way junction DNA binding(GO:0000400)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.0 0.6 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 3.6 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.6 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 0.8 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.6 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.5 PID_IL23_PATHWAY IL23-mediated signaling events
0.0 0.6 PID_TNF_PATHWAY TNF receptor signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.4 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 3.8 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.5 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.6 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.0 0.8 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.6 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 1.3 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.9 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.6 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.0 1.2 REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.0 0.3 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.3 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling