Motif ID: Hdx

Z-value: 6.316


Transcription factors associated with Hdx:

Gene SymbolEntrez IDGene Name
Hdx ENSMUSG00000034551.6 Hdx

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hdxmm10_v2_chrX_-_111697069_111697127-0.144.0e-01Click!


Activity profile for motif Hdx.

activity profile for motif Hdx


Sorted Z-values histogram for motif Hdx

Sorted Z-values for motif Hdx



Network of associatons between targets according to the STRING database.



First level regulatory network of Hdx

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_3017408 305.046 ENSMUST00000099049.3
Gm10719
predicted gene 10719
chr9_+_3015654 257.523 ENSMUST00000099050.3
Gm10720
predicted gene 10720
chr9_+_3023547 254.191 ENSMUST00000099046.3
Gm10718
predicted gene 10718
chr9_+_3005125 224.645 ENSMUST00000179881.1
Gm11168
predicted gene 11168
chr9_+_3000922 219.858 ENSMUST00000151376.2
Gm10722
predicted gene 10722
chr9_+_3034599 215.520 ENSMUST00000178641.1
Gm17535
predicted gene, 17535
chr9_+_3027439 214.309 ENSMUST00000177875.1
ENSMUST00000179982.1
Gm10717

predicted gene 10717

chr9_+_3025417 186.771 ENSMUST00000075573.6
Gm10717
predicted gene 10717
chr14_-_19418930 173.676 ENSMUST00000177817.1
Gm21738
predicted gene, 21738
chr9_+_3018753 151.940 ENSMUST00000179272.1
Gm10719
predicted gene 10719
chr9_+_3004457 139.438 ENSMUST00000178348.1
Gm11168
predicted gene 11168
chr9_+_3036877 138.657 ENSMUST00000155807.2
Gm10715
predicted gene 10715
chr9_+_3037111 129.506 ENSMUST00000177969.1
Gm10715
predicted gene 10715
chr9_+_3013140 120.753 ENSMUST00000143083.2
Gm10721
predicted gene 10721
chr2_-_98667264 91.588 ENSMUST00000099683.1
Gm10800
predicted gene 10800
chr6_-_23248264 20.461 ENSMUST00000031709.5
Fezf1
Fez family zinc finger 1
chr6_+_30568367 9.508 ENSMUST00000049251.5
Cpa4
carboxypeptidase A4
chr3_-_154330543 9.296 ENSMUST00000184966.1
ENSMUST00000177846.2
Lhx8

LIM homeobox protein 8

chrX_+_56779699 9.227 ENSMUST00000114772.2
ENSMUST00000114768.3
ENSMUST00000155882.1
Fhl1


four and a half LIM domains 1


chr13_+_24327415 8.732 ENSMUST00000167746.1
Cmah
cytidine monophospho-N-acetylneuraminic acid hydroxylase
chrX_+_56779437 7.787 ENSMUST00000114773.3
Fhl1
four and a half LIM domains 1
chr7_+_46847128 7.656 ENSMUST00000005051.4
Ldha
lactate dehydrogenase A
chr4_-_97584605 7.385 ENSMUST00000107067.1
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr4_-_97584612 7.101 ENSMUST00000107068.2
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr16_-_26989974 6.586 ENSMUST00000089832.4
Gmnc
geminin coiled-coil domain containing
chr2_+_105682463 6.208 ENSMUST00000140173.1
ENSMUST00000135412.1
ENSMUST00000138365.1
ENSMUST00000145744.1
Pax6



paired box gene 6



chr4_+_89137122 5.990 ENSMUST00000058030.7
Mtap
methylthioadenosine phosphorylase
chr11_-_109472611 5.752 ENSMUST00000168740.1
Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr14_+_62292475 5.716 ENSMUST00000166879.1
Rnaseh2b
ribonuclease H2, subunit B
chrX_-_143827391 5.677 ENSMUST00000087316.5
Capn6
calpain 6
chr13_+_21717626 5.027 ENSMUST00000091754.2
Hist1h3h
histone cluster 1, H3h
chr4_-_43031429 5.007 ENSMUST00000136326.1
Stoml2
stomatin (Epb7.2)-like 2
chr13_+_23752267 4.677 ENSMUST00000091703.2
Hist1h3b
histone cluster 1, H3b
chr4_-_43031370 4.350 ENSMUST00000138030.1
Stoml2
stomatin (Epb7.2)-like 2
chr9_+_45055166 4.141 ENSMUST00000114664.1
ENSMUST00000093856.3
Mpzl3

myelin protein zero-like 3

chr3_+_95929325 4.086 ENSMUST00000171368.1
ENSMUST00000168106.1
Anp32e

acidic (leucine-rich) nuclear phosphoprotein 32 family, member E

chr1_-_84935089 3.991 ENSMUST00000027422.5
Slc16a14
solute carrier family 16 (monocarboxylic acid transporters), member 14
chr4_-_82850721 3.788 ENSMUST00000139401.1
Zdhhc21
zinc finger, DHHC domain containing 21
chr4_-_133753611 3.706 ENSMUST00000145664.2
ENSMUST00000105897.3
Arid1a

AT rich interactive domain 1A (SWI-like)

chr4_+_3938904 3.675 ENSMUST00000120732.1
ENSMUST00000041122.4
ENSMUST00000121651.1
ENSMUST00000121210.1
ENSMUST00000119307.1
ENSMUST00000123769.1
Chchd7





coiled-coil-helix-coiled-coil-helix domain containing 7





chr11_-_121204626 3.219 ENSMUST00000026169.6
Ogfod3
2-oxoglutarate and iron-dependent oxygenase domain containing 3
chr14_+_70774304 2.910 ENSMUST00000022698.7
Dok2
docking protein 2
chr11_-_89418948 2.878 ENSMUST00000050983.1
4932411E22Rik
RIKEN cDNA 4932411E22 gene
chr16_-_50432340 2.139 ENSMUST00000066037.6
ENSMUST00000089399.4
ENSMUST00000089404.3
ENSMUST00000114477.1
ENSMUST00000138166.1
Bbx




bobby sox homolog (Drosophila)




chr11_+_117232254 2.113 ENSMUST00000106354.2
Sept9
septin 9
chr7_-_89980935 1.998 ENSMUST00000107234.1
Eed
embryonic ectoderm development
chr17_+_17402672 1.980 ENSMUST00000115576.2
Lix1
limb expression 1 homolog (chicken)
chr15_+_10177623 1.910 ENSMUST00000124470.1
Prlr
prolactin receptor
chr18_-_47333311 1.843 ENSMUST00000126684.1
ENSMUST00000156422.1
Sema6a

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

chr4_-_149126688 1.775 ENSMUST00000030815.2
Cort
cortistatin
chr10_-_80918212 1.672 ENSMUST00000057623.7
ENSMUST00000179022.1
Lmnb2

lamin B2

chr2_+_174415804 1.656 ENSMUST00000109075.1
ENSMUST00000016397.6
Nelfcd

negative elongation factor complex member C/D, Th1l

chr10_+_94576254 1.469 ENSMUST00000117929.1
Tmcc3
transmembrane and coiled coil domains 3
chr14_+_24490678 1.456 ENSMUST00000169826.1
ENSMUST00000112384.3
Rps24

ribosomal protein S24

chr5_-_27501362 1.362 ENSMUST00000155721.1
ENSMUST00000053257.3
Speer4b

spermatogenesis associated glutamate (E)-rich protein 4b

chr6_-_4086914 1.254 ENSMUST00000049166.4
Bet1
blocked early in transport 1 homolog (S. cerevisiae)
chr14_-_72602945 1.132 ENSMUST00000162825.1
Fndc3a
fibronectin type III domain containing 3A
chr14_+_73138755 1.107 ENSMUST00000171070.1
Rcbtb2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr16_+_14705832 1.102 ENSMUST00000023356.6
Snai2
snail homolog 2 (Drosophila)
chr16_+_37539883 0.970 ENSMUST00000023524.6
Rabl3
RAB, member of RAS oncogene family-like 3
chr11_-_67965631 0.959 ENSMUST00000021287.5
ENSMUST00000126766.1
Wdr16

WD repeat domain 16

chr14_-_68655804 0.959 ENSMUST00000111072.1
ENSMUST00000022642.5
Adam28

a disintegrin and metallopeptidase domain 28

chr12_-_27160311 0.860 ENSMUST00000182473.1
ENSMUST00000177636.1
ENSMUST00000183238.1
Gm9866


predicted gene 9866


chr13_+_43370710 0.805 ENSMUST00000066804.4
Sirt5
sirtuin 5
chrX_+_164419782 0.785 ENSMUST00000033754.7
Piga
phosphatidylinositol glycan anchor biosynthesis, class A
chr1_-_172027251 0.763 ENSMUST00000138714.1
Vangl2
vang-like 2 (van gogh, Drosophila)
chrX_+_143518576 0.602 ENSMUST00000033640.7
Pak3
p21 protein (Cdc42/Rac)-activated kinase 3
chrX_+_143518671 0.585 ENSMUST00000134402.1
Pak3
p21 protein (Cdc42/Rac)-activated kinase 3
chr10_+_85928491 0.540 ENSMUST00000170396.1
Ascl4
achaete-scute complex homolog 4 (Drosophila)
chr11_-_45955465 0.414 ENSMUST00000011398.6
Thg1l
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
chr5_-_107597533 0.360 ENSMUST00000124140.1
Glmn
glomulin, FKBP associated protein
chr5_+_30013141 0.328 ENSMUST00000026845.7
Il6
interleukin 6
chr19_+_8953826 0.294 ENSMUST00000096239.5
Tut1
terminal uridylyl transferase 1, U6 snRNA-specific
chr4_-_129640691 0.292 ENSMUST00000084264.5
Txlna
taxilin alpha
chr9_+_94669876 0.290 ENSMUST00000033463.9
Slc9a9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr18_-_35498856 0.252 ENSMUST00000025215.8
Sil1
endoplasmic reticulum chaperone SIL1 homolog (S. cerevisiae)
chr16_-_50330987 0.244 ENSMUST00000114488.1
Bbx
bobby sox homolog (Drosophila)
chr2_-_126618655 0.185 ENSMUST00000028838.4
Hdc
histidine decarboxylase
chr2_-_130629994 0.137 ENSMUST00000028761.4
ENSMUST00000110262.1
Ubox5
Fastkd5
U box domain containing 5
FAST kinase domains 5
chr16_+_35938470 0.060 ENSMUST00000114878.1
Parp9
poly (ADP-ribose) polymerase family, member 9
chr10_+_7667503 0.053 ENSMUST00000040135.8
Nup43
nucleoporin 43

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.4 20.5 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
3.1 9.4 GO:1990046 positive regulation of mitochondrial DNA replication(GO:0090297) regulation of cardiolipin metabolic process(GO:1900208) positive regulation of cardiolipin metabolic process(GO:1900210) stress-induced mitochondrial fusion(GO:1990046)
2.9 8.7 GO:0046381 CMP-N-acetylneuraminate metabolic process(GO:0046381)
1.5 7.7 GO:0019659 fermentation(GO:0006113) lactate biosynthetic process from pyruvate(GO:0019244) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
1.5 6.0 GO:0006166 purine ribonucleoside salvage(GO:0006166)
1.2 6.2 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
0.6 1.1 GO:1901420 negative regulation of response to alcohol(GO:1901420)
0.5 3.7 GO:0006344 maintenance of chromatin silencing(GO:0006344)
0.5 1.9 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.4 17.0 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.3 3.8 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.3 9.7 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.3 2.0 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.3 5.7 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.3 0.8 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.2 4.1 GO:0043486 histone exchange(GO:0043486)
0.2 6.6 GO:0006270 DNA replication initiation(GO:0006270)
0.2 2.1 GO:0045187 regulation of circadian sleep/wake cycle, sleep(GO:0045187)
0.1 9.3 GO:0021884 forebrain neuron development(GO:0021884)
0.1 1.8 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.1 1829.6 GO:0008150 biological_process(GO:0008150)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 9.3 GO:0001674 female germ cell nucleus(GO:0001674)
1.0 5.7 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.6 9.4 GO:0042101 T cell receptor complex(GO:0042101)
0.5 7.7 GO:0035686 sperm fibrous sheath(GO:0035686)
0.4 1.7 GO:0032021 NELF complex(GO:0032021)
0.3 9.7 GO:0000788 nuclear nucleosome(GO:0000788)
0.2 1.7 GO:0005638 lamin filament(GO:0005638)
0.2 2.0 GO:0001739 sex chromatin(GO:0001739)
0.2 3.7 GO:0071564 npBAF complex(GO:0071564)
0.2 0.8 GO:0060187 cell pole(GO:0060187)
0.1 2.1 GO:0031105 septin complex(GO:0031105)
0.1 0.3 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.1 1889.7 GO:0005575 cellular_component(GO:0005575)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 8.7 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
2.0 6.0 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
1.9 7.7 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
1.3 9.4 GO:1901612 phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)
0.8 5.7 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.4 6.2 GO:0003680 AT DNA binding(GO:0003680)
0.3 5.7 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.3 2.9 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.3 5.2 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.3 2.0 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.2 9.7 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.2 3.2 GO:0031418 L-ascorbic acid binding(GO:0031418)
0.1 3.8 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 3.7 GO:0031491 nucleosome binding(GO:0031491)
0.1 21.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 1865.3 GO:0003674 molecular_function(GO:0003674)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 7.7 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 2.9 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 1.9 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 1.2 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.0 1.7 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 0.3 ST_STAT3_PATHWAY STAT3 Pathway
0.0 1.1 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 6.2 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.4 6.0 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.3 7.7 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.2 9.7 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.2 1.9 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.1 3.8 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.1 1.8 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 1.0 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.8 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.3 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.0 1.5 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex