Motif ID: Isl2

Z-value: 0.781


Transcription factors associated with Isl2:

Gene SymbolEntrez IDGene Name
Isl2 ENSMUSG00000032318.6 Isl2



Activity profile for motif Isl2.

activity profile for motif Isl2


Sorted Z-values histogram for motif Isl2

Sorted Z-values for motif Isl2



Network of associatons between targets according to the STRING database.



First level regulatory network of Isl2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_60893430 4.730 ENSMUST00000135107.2
Sox3
SRY-box containing gene 3
chr12_-_10900296 3.041 ENSMUST00000085735.2
Pgk1-rs7
phosphoglycerate kinase-1, related sequence-7
chr17_-_48432723 3.037 ENSMUST00000046549.3
Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr10_-_77166545 2.746 ENSMUST00000081654.6
Col18a1
collagen, type XVIII, alpha 1
chr4_+_136172367 2.561 ENSMUST00000061721.5
E2f2
E2F transcription factor 2
chr9_-_100506844 2.498 ENSMUST00000112874.3
Nck1
non-catalytic region of tyrosine kinase adaptor protein 1
chrX_+_136245065 2.388 ENSMUST00000048687.4
Wbp5
WW domain binding protein 5
chr3_-_79841729 2.322 ENSMUST00000168038.1
Tmem144
transmembrane protein 144
chr8_-_61902669 2.256 ENSMUST00000121785.1
ENSMUST00000034057.7
Palld

palladin, cytoskeletal associated protein

chr4_+_105157339 2.139 ENSMUST00000064139.7
Ppap2b
phosphatidic acid phosphatase type 2B
chr17_+_17402672 2.123 ENSMUST00000115576.2
Lix1
limb expression 1 homolog (chicken)
chrX_+_96455359 2.114 ENSMUST00000033553.7
Heph
hephaestin
chr1_+_110099295 1.999 ENSMUST00000134301.1
Cdh7
cadherin 7, type 2
chr13_-_58354862 1.913 ENSMUST00000043605.5
Kif27
kinesin family member 27
chr12_-_99883429 1.869 ENSMUST00000046485.3
Efcab11
EF-hand calcium binding domain 11
chr4_+_3940747 1.863 ENSMUST00000119403.1
Chchd7
coiled-coil-helix-coiled-coil-helix domain containing 7
chr17_+_20570362 1.837 ENSMUST00000095633.3
Gm5145
predicted pseudogene 5145
chr3_-_33082004 1.809 ENSMUST00000108225.3
Pex5l
peroxisomal biogenesis factor 5-like
chr15_+_16778101 1.779 ENSMUST00000026432.6
Cdh9
cadherin 9
chr14_+_27039001 1.752 ENSMUST00000035336.3
Il17rd
interleukin 17 receptor D
chr13_+_104229366 1.750 ENSMUST00000022227.6
Cenpk
centromere protein K
chrY_-_1245753 1.745 ENSMUST00000154004.1
Uty
ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome
chr12_+_109546409 1.669 ENSMUST00000143847.1
Meg3
maternally expressed 3
chr16_-_16829276 1.664 ENSMUST00000023468.5
Spag6
sperm associated antigen 6
chr16_-_76403673 1.651 ENSMUST00000052867.7
Gm9843
predicted gene 9843
chrX_-_134111852 1.603 ENSMUST00000033610.6
Nox1
NADPH oxidase 1
chr8_+_114133635 1.598 ENSMUST00000147605.1
ENSMUST00000134593.1
Nudt7

nudix (nucleoside diphosphate linked moiety X)-type motif 7

chr8_+_114133557 1.597 ENSMUST00000073521.5
ENSMUST00000066514.6
Nudt7

nudix (nucleoside diphosphate linked moiety X)-type motif 7

chr7_+_100159241 1.588 ENSMUST00000032967.3
Lipt2
lipoyl(octanoyl) transferase 2 (putative)
chr9_+_53771499 1.586 ENSMUST00000048670.8
Slc35f2
solute carrier family 35, member F2
chr1_-_139377094 1.549 ENSMUST00000131586.1
ENSMUST00000145244.1
Crb1

crumbs homolog 1 (Drosophila)

chr10_-_13324160 1.396 ENSMUST00000105545.4
Phactr2
phosphatase and actin regulator 2
chr1_-_9944103 1.364 ENSMUST00000182498.1
ENSMUST00000182742.1
ENSMUST00000182580.1
Snhg6


small nucleolar RNA host gene (non-protein coding) 6


chr17_+_12119274 1.349 ENSMUST00000024594.2
Agpat4
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
chr5_-_3647806 1.317 ENSMUST00000119783.1
ENSMUST00000007559.8
Gatad1

GATA zinc finger domain containing 1

chr9_+_108560422 1.308 ENSMUST00000081111.8
Impdh2
inosine 5'-phosphate dehydrogenase 2
chr2_+_115581667 1.303 ENSMUST00000166472.1
ENSMUST00000110918.2
BC052040

cDNA sequence BC052040

chr17_-_26099257 1.268 ENSMUST00000053575.3
Gm8186
predicted gene 8186
chr19_+_5490475 1.255 ENSMUST00000116560.2
Cfl1
cofilin 1, non-muscle
chr1_-_72874877 1.241 ENSMUST00000027377.8
Igfbp5
insulin-like growth factor binding protein 5
chr17_-_53867041 1.232 ENSMUST00000061311.7
Mrps36-ps1
mitichondrial ribosomal protein S36, pseudogene 1
chr3_-_51408925 1.205 ENSMUST00000038108.6
Ndufc1
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1
chr14_-_31323884 1.177 ENSMUST00000048603.7
Dnah1
dynein, axonemal, heavy chain 1
chr1_-_128102412 1.154 ENSMUST00000112538.1
ENSMUST00000086614.5
Zranb3

zinc finger, RAN-binding domain containing 3

chr2_+_163658370 1.090 ENSMUST00000164399.1
ENSMUST00000064703.6
ENSMUST00000099105.2
ENSMUST00000152418.1
ENSMUST00000126182.1
ENSMUST00000131228.1
Pkig





protein kinase inhibitor, gamma





chrM_+_9452 1.090 ENSMUST00000082411.1
mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chr10_-_61784014 1.049 ENSMUST00000020283.4
H2afy2
H2A histone family, member Y2
chr11_+_69838514 1.044 ENSMUST00000133967.1
ENSMUST00000094065.4
Tmem256

transmembrane protein 256

chr2_+_109280738 1.014 ENSMUST00000028527.7
Kif18a
kinesin family member 18A
chr7_+_28881656 0.982 ENSMUST00000066880.4
Capn12
calpain 12
chr11_+_58171648 0.976 ENSMUST00000020820.1
Mrpl22
mitochondrial ribosomal protein L22
chr5_-_87490869 0.950 ENSMUST00000147854.1
Ugt2a1
UDP glucuronosyltransferase 2 family, polypeptide A1
chr1_-_172027269 0.941 ENSMUST00000027837.6
ENSMUST00000111264.1
Vangl2

vang-like 2 (van gogh, Drosophila)

chr3_+_103171655 0.929 ENSMUST00000005830.8
Bcas2
breast carcinoma amplified sequence 2
chr14_-_62454793 0.928 ENSMUST00000128573.1
Gucy1b2
guanylate cyclase 1, soluble, beta 2
chr15_-_35938009 0.917 ENSMUST00000156915.1
Cox6c
cytochrome c oxidase subunit VIc
chr5_+_15516489 0.894 ENSMUST00000178227.1
Gm21847
predicted gene, 21847
chr3_+_89459118 0.869 ENSMUST00000029564.5
Pmvk
phosphomevalonate kinase
chr10_+_94576254 0.825 ENSMUST00000117929.1
Tmcc3
transmembrane and coiled coil domains 3
chr12_+_87443896 0.812 ENSMUST00000161023.1
ENSMUST00000160488.1
ENSMUST00000077462.7
ENSMUST00000160880.1
Slirp



SRA stem-loop interacting RNA binding protein



chr11_+_94327984 0.811 ENSMUST00000107818.2
ENSMUST00000051221.6
Ankrd40

ankyrin repeat domain 40

chr1_-_163289214 0.809 ENSMUST00000183691.1
Prrx1
paired related homeobox 1
chr6_-_89595647 0.801 ENSMUST00000032172.8
ENSMUST00000113550.3
Chchd6

coiled-coil-helix-coiled-coil-helix domain containing 6

chr14_+_58893465 0.791 ENSMUST00000079960.1
Rpl13-ps3
ribosomal protein L13, pseudogene 3
chr14_+_4198185 0.790 ENSMUST00000180184.1
Gm2974
predicted gene 2974
chr6_-_136941887 0.790 ENSMUST00000111891.1
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr15_-_35938186 0.787 ENSMUST00000014457.8
Cox6c
cytochrome c oxidase subunit VIc
chr5_+_30105161 0.784 ENSMUST00000058045.4
Gareml
GRB2 associated, regulator of MAPK1-like
chr9_+_72806874 0.760 ENSMUST00000055535.8
Prtg
protogenin homolog (Gallus gallus)
chr17_+_78916473 0.760 ENSMUST00000063817.4
ENSMUST00000180077.1
1110001A16Rik

RIKEN cDNA 1110001A16 gene

chr12_-_84617326 0.755 ENSMUST00000021666.4
Abcd4
ATP-binding cassette, sub-family D (ALD), member 4
chr9_+_70012540 0.742 ENSMUST00000118198.1
ENSMUST00000119905.1
ENSMUST00000119413.1
ENSMUST00000140305.1
ENSMUST00000122087.1
Gtf2a2




general transcription factor II A, 2




chr15_-_10485385 0.735 ENSMUST00000168690.1
Brix1
BRX1, biogenesis of ribosomes, homolog (S. cerevisiae)
chr4_+_32623985 0.734 ENSMUST00000108178.1
Casp8ap2
caspase 8 associated protein 2
chr19_-_44552831 0.728 ENSMUST00000166808.1
Gm20538
predicted gene 20538
chr4_-_14621669 0.724 ENSMUST00000143105.1
Slc26a7
solute carrier family 26, member 7
chr19_+_25406661 0.721 ENSMUST00000146647.1
Kank1
KN motif and ankyrin repeat domains 1
chr2_-_150255591 0.716 ENSMUST00000063463.5
Gm21994
predicted gene 21994
chr10_+_102158858 0.713 ENSMUST00000138522.1
ENSMUST00000163753.1
ENSMUST00000138016.1
Mgat4c


mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)


chr1_+_12718496 0.712 ENSMUST00000088585.3
Sulf1
sulfatase 1
chr9_-_22117123 0.704 ENSMUST00000013966.6
Elof1
elongation factor 1 homolog (ELF1, S. cerevisiae)
chr15_+_84232030 0.702 ENSMUST00000023072.6
Parvb
parvin, beta
chr16_-_35939082 0.690 ENSMUST00000081933.7
ENSMUST00000114885.1
Dtx3l

deltex 3-like (Drosophila)

chr3_-_62605140 0.688 ENSMUST00000058535.5
Gpr149
G protein-coupled receptor 149
chr17_+_82539258 0.683 ENSMUST00000097278.3
Gm6594
predicted pseudogene 6594
chrM_+_8600 0.662 ENSMUST00000082409.1
mt-Co3
mitochondrially encoded cytochrome c oxidase III
chr15_-_10485890 0.659 ENSMUST00000169050.1
ENSMUST00000022855.5
Brix1

BRX1, biogenesis of ribosomes, homolog (S. cerevisiae)

chr12_-_87444017 0.646 ENSMUST00000091090.4
2700073G19Rik
RIKEN cDNA 2700073G19 gene
chr10_-_80918212 0.632 ENSMUST00000057623.7
ENSMUST00000179022.1
Lmnb2

lamin B2

chr1_+_187215501 0.626 ENSMUST00000097443.3
ENSMUST00000065573.7
ENSMUST00000110943.2
ENSMUST00000044812.5
Gpatch2



G patch domain containing 2



chr9_+_35423582 0.617 ENSMUST00000154652.1
Cdon
cell adhesion molecule-related/down-regulated by oncogenes
chr13_+_48513570 0.572 ENSMUST00000065465.1
A830005F24Rik
RIKEN cDNA A830005F24 gene
chr17_+_56613392 0.562 ENSMUST00000080492.5
Rpl36
ribosomal protein L36
chr1_+_45981548 0.549 ENSMUST00000085632.2
Rpl23a-ps1
ribosomal protein 23A, pseudogene 1
chr4_-_88722454 0.545 ENSMUST00000094993.2
Klhl9
kelch-like 9
chr4_-_136053343 0.539 ENSMUST00000102536.4
Rpl11
ribosomal protein L11
chr8_-_125492710 0.534 ENSMUST00000108775.1
Sipa1l2
signal-induced proliferation-associated 1 like 2
chr18_-_43477764 0.527 ENSMUST00000057110.9
Eif3j2
eukaryotic translation initiation factor 3, subunit J2
chr14_+_5517172 0.524 ENSMUST00000178220.1
Gm3488
predicted gene, 3488
chr14_+_5164535 0.524 ENSMUST00000179659.1
Gm3317
predicted gene 3317
chr11_-_101278927 0.510 ENSMUST00000168089.1
ENSMUST00000017332.3
Coa3

cytochrome C oxidase assembly factor 3

chr12_+_10390756 0.502 ENSMUST00000020947.5
Rdh14
retinol dehydrogenase 14 (all-trans and 9-cis)
chr1_-_127840290 0.499 ENSMUST00000061512.2
Map3k19
mitogen-activated protein kinase kinase kinase 19
chr11_+_5520652 0.498 ENSMUST00000063084.9
Xbp1
X-box binding protein 1
chr3_+_41563356 0.488 ENSMUST00000163764.1
Phf17
PHD finger protein 17
chr3_+_138374121 0.481 ENSMUST00000171054.1
Adh6-ps1
alcohol dehydrogenase 6 (class V), pseudogene 1
chrX_+_9885622 0.462 ENSMUST00000067529.2
ENSMUST00000086165.3
Sytl5

synaptotagmin-like 5

chr7_+_126976338 0.459 ENSMUST00000032920.3
Cdipt
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)
chr3_-_67463828 0.454 ENSMUST00000058981.2
Lxn
latexin
chr4_-_14621805 0.450 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chr11_+_103649498 0.450 ENSMUST00000057870.2
Rprml
reprimo-like
chr18_-_36766198 0.448 ENSMUST00000061522.7
Dnd1
dead end homolog 1 (zebrafish)
chrX_+_164373363 0.439 ENSMUST00000033751.7
Figf
c-fos induced growth factor
chr5_-_24902315 0.429 ENSMUST00000131486.1
Prkag2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr10_+_69208546 0.422 ENSMUST00000164034.1
Rhobtb1
Rho-related BTB domain containing 1
chr11_-_17953861 0.414 ENSMUST00000076661.6
Etaa1
Ewing's tumor-associated antigen 1
chr4_-_14621494 0.406 ENSMUST00000149633.1
Slc26a7
solute carrier family 26, member 7
chr3_-_9004422 0.370 ENSMUST00000063496.7
Tpd52
tumor protein D52
chr5_-_88675190 0.368 ENSMUST00000133532.1
ENSMUST00000150438.1
Grsf1

G-rich RNA sequence binding factor 1

chr10_-_63927434 0.351 ENSMUST00000079279.3
Gm10118
predicted gene 10118
chr14_-_6411578 0.349 ENSMUST00000179312.1
Gm3591
predicted gene 3591
chr14_+_3667518 0.346 ENSMUST00000112801.3
Gm3020
predicted gene 3020
chrM_-_14060 0.344 ENSMUST00000082419.1
mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr14_+_4741737 0.339 ENSMUST00000178748.1
Gm3252
predicted gene 3252
chr14_-_69707546 0.338 ENSMUST00000118374.1
R3hcc1
R3H domain and coiled-coil containing 1
chr14_+_3825596 0.310 ENSMUST00000178256.1
Gm3002
predicted gene 3002
chr14_-_7473073 0.305 ENSMUST00000167833.2
Gm3752
predicted gene 3752
chr14_-_69707493 0.300 ENSMUST00000121142.1
R3hcc1
R3H domain and coiled-coil containing 1
chr10_-_85127977 0.295 ENSMUST00000050813.2
Mterfd3
MTERF domain containing 3
chr4_-_86669492 0.286 ENSMUST00000149700.1
Plin2
perilipin 2
chr7_+_19119853 0.283 ENSMUST00000053109.3
Fbxo46
F-box protein 46
chr1_-_185329331 0.282 ENSMUST00000027921.4
ENSMUST00000110975.1
ENSMUST00000110974.3
Iars2


isoleucine-tRNA synthetase 2, mitochondrial


chr14_+_3348089 0.281 ENSMUST00000178722.1
Gm2956
predicted gene 2956
chr8_-_9976294 0.278 ENSMUST00000095476.4
Lig4
ligase IV, DNA, ATP-dependent
chr14_-_6266620 0.270 ENSMUST00000096172.5
Gm3411
predicted gene 3411
chr8_+_88118747 0.264 ENSMUST00000095214.3
Cnep1r1
CTD nuclear envelope phosphatase 1 regulatory subunit 1
chr14_+_4126066 0.264 ENSMUST00000167397.2
Gm8108
predicted gene 8108
chr14_-_6874257 0.241 ENSMUST00000178298.1
ENSMUST00000179374.1
Gm3667
Gm3629
predicted gene 3667
predicted gene 3629
chr14_+_3428103 0.236 ENSMUST00000178060.1
Gm3005
predicted gene 3005
chr3_-_67515487 0.226 ENSMUST00000178314.1
ENSMUST00000054825.4
Rarres1

retinoic acid receptor responder (tazarotene induced) 1

chr14_+_4665094 0.223 ENSMUST00000169675.2
Gm3239
predicted gene 3239
chr15_-_100424092 0.221 ENSMUST00000154676.1
Slc11a2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr4_+_145510759 0.211 ENSMUST00000105742.1
ENSMUST00000136309.1
Gm13225

predicted gene 13225

chrX_-_20931520 0.203 ENSMUST00000001156.7
Cfp
complement factor properdin
chr3_+_83055516 0.199 ENSMUST00000150268.1
ENSMUST00000122128.1
Plrg1

pleiotropic regulator 1, PRL1 homolog (Arabidopsis)

chr17_-_56036546 0.197 ENSMUST00000003268.9
Sh3gl1
SH3-domain GRB2-like 1
chr15_-_37459327 0.196 ENSMUST00000119730.1
ENSMUST00000120746.1
Ncald

neurocalcin delta

chr1_-_156034800 0.192 ENSMUST00000169241.1
Tor1aip1
torsin A interacting protein 1
chr11_-_116027961 0.192 ENSMUST00000106454.1
H3f3b
H3 histone, family 3B
chr1_+_156838915 0.187 ENSMUST00000111720.1
Angptl1
angiopoietin-like 1
chr14_+_4871156 0.186 ENSMUST00000166410.2
Gm3264
predicted gene 3264
chr14_-_5863663 0.178 ENSMUST00000178594.1
Gm8237
predicted gene 8237
chr7_-_100656953 0.170 ENSMUST00000107046.1
ENSMUST00000107045.1
ENSMUST00000139708.1
Plekhb1


pleckstrin homology domain containing, family B (evectins) member 1


chr3_+_41024369 0.163 ENSMUST00000099121.3
Larp1b
La ribonucleoprotein domain family, member 1B
chr3_-_41742471 0.140 ENSMUST00000026866.8
Sclt1
sodium channel and clathrin linker 1
chr18_+_23753708 0.114 ENSMUST00000115830.1
Mapre2
microtubule-associated protein, RP/EB family, member 2
chr14_-_19569553 0.112 ENSMUST00000112595.2
Gm2237
predicted gene 2237
chr19_+_5474681 0.110 ENSMUST00000165485.1
ENSMUST00000166253.1
ENSMUST00000167371.1
ENSMUST00000167855.1
ENSMUST00000070118.7
Efemp2




epidermal growth factor-containing fibulin-like extracellular matrix protein 2




chr6_-_83121385 0.108 ENSMUST00000146328.1
ENSMUST00000113936.3
ENSMUST00000032111.4
Wbp1


WW domain binding protein 1


chr10_-_31445921 0.107 ENSMUST00000000305.5
Tpd52l1
tumor protein D52-like 1
chr11_-_82908360 0.106 ENSMUST00000103213.3
Nle1
notchless homolog 1 (Drosophila)
chrX_+_101383726 0.093 ENSMUST00000119190.1
Gjb1
gap junction protein, beta 1
chr17_-_56005566 0.090 ENSMUST00000043785.6
Stap2
signal transducing adaptor family member 2
chrX_-_75578188 0.086 ENSMUST00000033545.5
Rab39b
RAB39B, member RAS oncogene family
chrM_+_3906 0.080 ENSMUST00000082396.1
mt-Nd2
mitochondrially encoded NADH dehydrogenase 2
chr6_+_134640940 0.078 ENSMUST00000062755.8
Loh12cr1
loss of heterozygosity, 12, chromosomal region 1 homolog (human)
chr4_+_134102581 0.075 ENSMUST00000074690.4
ENSMUST00000070246.2
ENSMUST00000156750.1
Ubxn11


UBX domain protein 11


chr15_+_10486008 0.070 ENSMUST00000022856.8
ENSMUST00000100775.3
ENSMUST00000169519.1
Rad1


RAD1 homolog (S. pombe)


chr8_+_93810832 0.065 ENSMUST00000034198.8
ENSMUST00000125716.1
Gnao1

guanine nucleotide binding protein, alpha O

chr6_-_42710036 0.063 ENSMUST00000045054.4
Fam115a
family with sequence similarity 115, member A
chr14_+_4430992 0.060 ENSMUST00000164603.1
ENSMUST00000166848.1
Gm3173

predicted gene 3173

chr10_-_127311740 0.057 ENSMUST00000037290.5
ENSMUST00000171564.1
Mars

methionine-tRNA synthetase

chr8_+_25911670 0.051 ENSMUST00000120653.1
ENSMUST00000126226.1
Kcnu1

potassium channel, subfamily U, member 1

chr9_+_119341294 0.046 ENSMUST00000039784.5
Acaa1a
acetyl-Coenzyme A acyltransferase 1A
chr8_+_107031218 0.037 ENSMUST00000034388.9
Vps4a
vacuolar protein sorting 4a (yeast)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.2 GO:0015938 coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034) acetyl-CoA catabolic process(GO:0046356)
1.0 3.0 GO:0016554 cytidine to uridine editing(GO:0016554)
0.8 2.5 GO:0002191 cap-dependent translational initiation(GO:0002191)
0.7 2.0 GO:0071963 establishment or maintenance of cell polarity regulating cell shape(GO:0071963)
0.5 1.6 GO:0009106 lipoate metabolic process(GO:0009106)
0.4 1.6 GO:0072592 regulation of integrin biosynthetic process(GO:0045113) oxygen metabolic process(GO:0072592)
0.4 1.2 GO:0036292 DNA rewinding(GO:0036292)
0.4 2.6 GO:1990086 lens fiber cell apoptotic process(GO:1990086)
0.3 0.9 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.3 1.3 GO:0006177 GMP biosynthetic process(GO:0006177)
0.3 1.8 GO:0051461 protein import into peroxisome matrix, docking(GO:0016560) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.2 0.7 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.2 0.7 GO:0048162 preantral ovarian follicle growth(GO:0001546) multi-layer follicle stage(GO:0048162)
0.2 1.6 GO:0019532 oxalate transport(GO:0019532)
0.2 4.7 GO:0007530 sex determination(GO:0007530)
0.2 1.7 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.2 0.9 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.2 0.8 GO:0000957 mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
0.2 1.0 GO:0052695 cellular glucuronidation(GO:0052695)
0.2 0.5 GO:2000435 regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
0.2 0.7 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.2 2.3 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.2 1.2 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.2 1.0 GO:1901837 negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837)
0.2 3.2 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.2 0.5 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.1 0.8 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.1 0.8 GO:0009235 cobalamin metabolic process(GO:0009235)
0.1 0.7 GO:0036337 Fas signaling pathway(GO:0036337)
0.1 2.3 GO:0071803 keratinocyte development(GO:0003334) positive regulation of podosome assembly(GO:0071803)
0.1 0.3 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.1 1.1 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.1 1.2 GO:0060294 cilium movement involved in cell motility(GO:0060294)
0.1 2.2 GO:0006825 copper ion transport(GO:0006825)
0.1 0.8 GO:0048664 neuron fate determination(GO:0048664)
0.1 2.1 GO:0097352 autophagosome maturation(GO:0097352)
0.1 1.0 GO:0072520 seminiferous tubule development(GO:0072520)
0.1 0.8 GO:0042407 cristae formation(GO:0042407)
0.0 1.5 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 1.3 GO:0008340 determination of adult lifespan(GO:0008340)
0.0 0.2 GO:1902340 telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340)
0.0 0.3 GO:0002681 somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153) double-strand break repair via classical nonhomologous end joining(GO:0097680)
0.0 0.5 GO:0042572 retinol metabolic process(GO:0042572)
0.0 1.9 GO:0021591 ventricular system development(GO:0021591)
0.0 0.6 GO:0060059 embryonic retina morphogenesis in camera-type eye(GO:0060059)
0.0 1.5 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 0.7 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.5 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.0 0.2 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.4 GO:0060965 negative regulation of gene silencing by miRNA(GO:0060965)
0.0 1.2 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.7 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 0.9 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.0 0.1 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 1.9 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.2 GO:0071763 nuclear membrane organization(GO:0071763)
0.0 0.4 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.0 0.7 GO:0010390 histone monoubiquitination(GO:0010390)
0.0 0.2 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.0 0.4 GO:0010800 positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0 0.5 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.0 GO:0072319 vesicle uncoating(GO:0072319)
0.0 0.1 GO:0045835 negative regulation of meiotic nuclear division(GO:0045835)
0.0 0.7 GO:0009060 aerobic respiration(GO:0009060)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.8 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.4 1.6 GO:0071438 invadopodium membrane(GO:0071438)
0.3 1.2 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.2 0.9 GO:0060187 cell pole(GO:0060187)
0.2 2.5 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.2 0.5 GO:0036156 inner dynein arm(GO:0036156)
0.1 1.0 GO:0001740 Barr body(GO:0001740)
0.1 0.7 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.1 1.0 GO:0005828 kinetochore microtubule(GO:0005828)
0.1 0.2 GO:0070469 respiratory chain(GO:0070469)
0.1 0.6 GO:0005638 lamin filament(GO:0005638)
0.1 0.8 GO:0061617 MICOS complex(GO:0061617)
0.1 1.1 GO:0000974 Prp19 complex(GO:0000974)
0.1 2.3 GO:0002102 podosome(GO:0002102)
0.0 0.9 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.3 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) DNA ligase IV complex(GO:0032807)
0.0 2.7 GO:0005581 collagen trimer(GO:0005581)
0.0 1.7 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 6.0 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.5 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 1.9 GO:0005871 kinesin complex(GO:0005871)
0.0 1.1 GO:0043596 nuclear replication fork(GO:0043596)
0.0 0.4 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 1.5 GO:0005902 microvillus(GO:0005902)
0.0 0.6 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 1.0 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.4 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 1.1 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.7 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 1.3 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.1 GO:0071439 clathrin complex(GO:0071439)
0.0 2.1 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.1 GO:0030896 checkpoint clamp complex(GO:0030896)
0.0 1.8 GO:0000776 kinetochore(GO:0000776)
0.0 0.4 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.2 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.8 3.0 GO:0004126 cytidine deaminase activity(GO:0004126)
0.6 1.8 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.5 1.6 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.4 2.1 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.4 2.5 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.4 1.8 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.3 1.3 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.2 1.7 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.2 1.2 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 1.6 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.1 0.7 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1 0.7 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 4.7 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 0.8 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 2.4 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.7 GO:0032184 SUMO polymer binding(GO:0032184)
0.1 1.5 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.1 1.2 GO:0036310 annealing helicase activity(GO:0036310)
0.1 0.3 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.1 2.9 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 0.5 GO:1990948 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.1 1.3 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 0.5 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.1 0.7 GO:0042923 neuropeptide binding(GO:0042923)
0.1 1.0 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 2.3 GO:0015144 carbohydrate transmembrane transporter activity(GO:0015144) carbohydrate transporter activity(GO:1901476)
0.0 0.9 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.3 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0 0.5 GO:0008106 alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.0 0.5 GO:0045503 dynein light chain binding(GO:0045503)
0.0 0.5 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.5 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0 0.7 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.8 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.7 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 0.7 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.1 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.0 0.1 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.0 0.9 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.0 0.5 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.4 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.4 GO:0017091 AU-rich element binding(GO:0017091)
0.0 1.3 GO:1902936 phosphatidylinositol bisphosphate binding(GO:1902936)
0.0 2.3 GO:0001047 core promoter binding(GO:0001047)
0.0 0.1 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.8 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1 2.7 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 2.5 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.7 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.4 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 0.6 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.6 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 1.8 PID_FGF_PATHWAY FGF signaling pathway
0.0 1.3 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 0.7 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 0.5 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.4 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.3 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.6 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.2 2.5 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 3.8 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 1.0 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.1 1.3 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 2.1 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.1 1.2 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 0.5 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 2.1 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 2.9 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 1.3 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.0 0.7 REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.0 1.0 REACTOME_KINESINS Genes involved in Kinesins
0.0 0.7 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.4 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.9 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.4 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 1.8 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.7 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.6 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 0.3 REACTOME_INTEGRATION_OF_PROVIRUS Genes involved in Integration of provirus
0.0 0.7 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.2 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 1.4 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.5 REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.0 0.3 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 1.8 REACTOME_SIGNALING_BY_FGFR Genes involved in Signaling by FGFR
0.0 0.2 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening