Motif ID: Twist1

Z-value: 0.948


Transcription factors associated with Twist1:

Gene SymbolEntrez IDGene Name
Twist1 ENSMUSG00000035799.5 Twist1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Twist1mm10_v2_chr12_+_33957645_339576710.192.3e-01Click!


Activity profile for motif Twist1.

activity profile for motif Twist1


Sorted Z-values histogram for motif Twist1

Sorted Z-values for motif Twist1



Network of associatons between targets according to the STRING database.



First level regulatory network of Twist1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_60794468 4.831 ENSMUST00000050183.6
Uaca
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr7_+_4119525 4.379 ENSMUST00000119661.1
ENSMUST00000129423.1
Ttyh1

tweety homolog 1 (Drosophila)

chr7_+_4119556 4.367 ENSMUST00000079415.5
Ttyh1
tweety homolog 1 (Drosophila)
chr6_-_95718800 4.191 ENSMUST00000079847.5
Suclg2
succinate-Coenzyme A ligase, GDP-forming, beta subunit
chr1_-_119053339 3.802 ENSMUST00000161301.1
ENSMUST00000161451.1
ENSMUST00000162607.1
Gli2


GLI-Kruppel family member GLI2


chr2_-_172940299 3.759 ENSMUST00000009143.7
Bmp7
bone morphogenetic protein 7
chr11_-_59290746 3.730 ENSMUST00000010044.7
Wnt3a
wingless-related MMTV integration site 3A
chr19_+_25610533 3.706 ENSMUST00000048935.4
Dmrt3
doublesex and mab-3 related transcription factor 3
chrX_+_100730178 3.621 ENSMUST00000113744.1
Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chr9_-_54661870 3.534 ENSMUST00000034822.5
Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr7_+_45216671 3.416 ENSMUST00000134420.1
Tead2
TEA domain family member 2
chr9_-_114844090 3.399 ENSMUST00000047013.3
Cmtm8
CKLF-like MARVEL transmembrane domain containing 8
chr18_+_60911757 2.677 ENSMUST00000040359.5
Arsi
arylsulfatase i
chr16_+_78930940 2.625 ENSMUST00000114216.1
ENSMUST00000069148.6
ENSMUST00000023568.7
Chodl


chondrolectin


chr10_-_127030813 2.553 ENSMUST00000040560.4
Tsfm
Ts translation elongation factor, mitochondrial
chr7_-_127218390 2.400 ENSMUST00000142356.1
ENSMUST00000106314.1
Sept1

septin 1

chr9_-_44342332 2.396 ENSMUST00000097558.3
Hmbs
hydroxymethylbilane synthase
chr7_-_127218303 2.289 ENSMUST00000106313.1
Sept1
septin 1
chr1_+_74791516 2.132 ENSMUST00000006718.8
Wnt10a
wingless related MMTV integration site 10a
chr9_-_54661666 2.074 ENSMUST00000128624.1
Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr2_-_26122769 2.057 ENSMUST00000140993.1
ENSMUST00000028300.5
Nacc2

nucleus accumbens associated 2, BEN and BTB (POZ) domain containing

chr8_-_71381907 2.027 ENSMUST00000002466.8
Nr2f6
nuclear receptor subfamily 2, group F, member 6
chr16_-_18811615 2.023 ENSMUST00000096990.3
Cdc45
cell division cycle 45
chr6_-_124813065 2.014 ENSMUST00000149610.2
Tpi1
triosephosphate isomerase 1
chr6_+_29398920 2.006 ENSMUST00000181464.1
ENSMUST00000180829.1
Ccdc136

coiled-coil domain containing 136

chr10_-_127341583 1.997 ENSMUST00000026474.3
Gli1
GLI-Kruppel family member GLI1
chr10_-_127030789 1.993 ENSMUST00000120547.1
ENSMUST00000152054.1
Tsfm

Ts translation elongation factor, mitochondrial

chr9_+_118478851 1.991 ENSMUST00000150633.1
Eomes
eomesodermin homolog (Xenopus laevis)
chr16_+_37776873 1.912 ENSMUST00000114763.2
Fstl1
follistatin-like 1
chr6_+_85187438 1.886 ENSMUST00000045942.8
Emx1
empty spiracles homeobox 1
chr2_-_180225812 1.883 ENSMUST00000015791.5
Lama5
laminin, alpha 5
chr8_+_105305572 1.675 ENSMUST00000109375.2
Elmo3
engulfment and cell motility 3
chr19_+_5740885 1.594 ENSMUST00000081496.5
Ltbp3
latent transforming growth factor beta binding protein 3
chrX_+_71050160 1.575 ENSMUST00000082088.3
ENSMUST00000114629.3
Mamld1

mastermind-like domain containing 1

chr19_-_3686549 1.540 ENSMUST00000025856.10
ENSMUST00000176867.1
Lrp5

low density lipoprotein receptor-related protein 5

chr18_-_67724560 1.478 ENSMUST00000120934.1
ENSMUST00000025420.7
ENSMUST00000122412.1
Ptpn2


protein tyrosine phosphatase, non-receptor type 2


chr8_+_72135247 1.458 ENSMUST00000003575.9
Tpm4
tropomyosin 4
chr6_+_83135812 1.437 ENSMUST00000065512.4
Rtkn
rhotekin
chr11_+_69935894 1.393 ENSMUST00000149194.1
Ybx2
Y box protein 2
chr11_-_119355484 1.363 ENSMUST00000100172.2
ENSMUST00000005173.4
Sgsh

N-sulfoglucosamine sulfohydrolase (sulfamidase)

chr19_-_24280551 1.347 ENSMUST00000081333.4
Fxn
frataxin
chr7_+_44468020 1.337 ENSMUST00000117324.1
ENSMUST00000120852.1
ENSMUST00000118628.1
Josd2


Josephin domain containing 2


chr17_+_45563928 1.301 ENSMUST00000041353.6
Slc35b2
solute carrier family 35, member B2
chr7_+_82867327 1.298 ENSMUST00000082237.5
Mex3b
mex3 homolog B (C. elegans)
chr4_-_129558355 1.264 ENSMUST00000167288.1
ENSMUST00000134336.1
Lck

lymphocyte protein tyrosine kinase

chr4_-_129558387 1.261 ENSMUST00000067240.4
Lck
lymphocyte protein tyrosine kinase
chr11_+_53770458 1.256 ENSMUST00000138913.1
ENSMUST00000123376.1
ENSMUST00000019043.6
ENSMUST00000133291.1
Irf1



interferon regulatory factor 1



chr4_-_11386757 1.233 ENSMUST00000108313.1
ENSMUST00000108311.2
Esrp1

epithelial splicing regulatory protein 1

chr11_+_69935796 1.150 ENSMUST00000018698.5
Ybx2
Y box protein 2
chr4_-_130275542 1.073 ENSMUST00000154846.1
ENSMUST00000105996.1
Serinc2

serine incorporator 2

chr11_+_97663366 1.070 ENSMUST00000044730.5
Mllt6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr4_-_57143437 1.052 ENSMUST00000095076.3
ENSMUST00000030142.3
Epb4.1l4b

erythrocyte protein band 4.1-like 4b

chr7_-_4789541 1.051 ENSMUST00000168578.1
Tmem238
transmembrane protein 238
chrX_-_18461371 1.047 ENSMUST00000044188.4
4930578C19Rik
RIKEN cDNA 4930578C19 gene
chr2_+_174110340 1.006 ENSMUST00000044415.9
Npepl1
aminopeptidase-like 1
chr11_+_94741782 0.991 ENSMUST00000021240.6
Cdc34-ps
cell division cycle 34 homolog, pseudogene (S. cerevisiae)
chr17_+_34039437 0.990 ENSMUST00000131134.1
ENSMUST00000087497.4
ENSMUST00000114255.1
ENSMUST00000114252.1
Col11a2



collagen, type XI, alpha 2



chr2_-_137116624 0.878 ENSMUST00000028735.7
Jag1
jagged 1
chr11_-_102406783 0.870 ENSMUST00000155104.1
ENSMUST00000130436.1
Slc25a39

solute carrier family 25, member 39

chr11_+_102189620 0.831 ENSMUST00000070334.3
ENSMUST00000078975.7
G6pc3

glucose 6 phosphatase, catalytic, 3

chr4_-_130275523 0.775 ENSMUST00000146478.1
Serinc2
serine incorporator 2
chr7_-_70360593 0.756 ENSMUST00000032768.7
Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr7_+_44468051 0.745 ENSMUST00000118493.1
Josd2
Josephin domain containing 2
chr6_-_90716489 0.744 ENSMUST00000101153.3
Iqsec1
IQ motif and Sec7 domain 1
chr15_+_100227819 0.742 ENSMUST00000023769.4
Atf1
activating transcription factor 1
chr1_+_171437535 0.732 ENSMUST00000043839.4
F11r
F11 receptor
chr2_-_142901506 0.712 ENSMUST00000043589.7
Kif16b
kinesin family member 16B
chr7_+_127800844 0.704 ENSMUST00000106271.1
ENSMUST00000138432.1
Hsd3b7

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7

chr7_+_27486910 0.700 ENSMUST00000008528.7
Sertad1
SERTA domain containing 1
chr11_+_72207537 0.684 ENSMUST00000021158.3
Txndc17
thioredoxin domain containing 17
chr14_-_62761112 0.641 ENSMUST00000053959.6
Ints6
integrator complex subunit 6
chr8_+_13757663 0.633 ENSMUST00000043962.8
Cdc16
CDC16 cell division cycle 16
chr8_-_64693027 0.627 ENSMUST00000048967.7
Cpe
carboxypeptidase E
chr9_+_55150050 0.605 ENSMUST00000122441.1
Ube2q2
ubiquitin-conjugating enzyme E2Q (putative) 2
chr5_+_105519388 0.602 ENSMUST00000067924.6
ENSMUST00000150981.1
Lrrc8c

leucine rich repeat containing 8 family, member C

chr3_+_90051630 0.602 ENSMUST00000159064.1
4933434E20Rik
RIKEN cDNA 4933434E20 gene
chr18_-_16809233 0.576 ENSMUST00000025166.7
Cdh2
cadherin 2
chr10_+_14523062 0.552 ENSMUST00000096020.5
Gm10335
predicted gene 10335
chr9_+_65265173 0.543 ENSMUST00000048762.1
Cilp
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
chr16_+_18426415 0.523 ENSMUST00000115606.1
ENSMUST00000115604.1
ENSMUST00000178093.1
ENSMUST00000177856.1
Txnrd2



thioredoxin reductase 2



chr9_+_111118070 0.486 ENSMUST00000035078.6
ENSMUST00000098340.2
Lrrfip2

leucine rich repeat (in FLII) interacting protein 2

chrX_-_104671048 0.450 ENSMUST00000042070.5
Zdhhc15
zinc finger, DHHC domain containing 15
chr15_+_100227871 0.434 ENSMUST00000163855.1
Atf1
activating transcription factor 1
chr7_-_80401707 0.433 ENSMUST00000120753.1
Furin
furin (paired basic amino acid cleaving enzyme)
chr14_-_50930803 0.432 ENSMUST00000160538.1
ENSMUST00000162957.1
ENSMUST00000161166.1
ENSMUST00000160835.1
ENSMUST00000049312.7
Tmem55b




transmembrane protein 55b




chr9_-_108567336 0.393 ENSMUST00000074208.4
Ndufaf3
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 3
chr10_-_75517324 0.376 ENSMUST00000039796.7
Gucd1
guanylyl cyclase domain containing 1
chr11_+_58009064 0.370 ENSMUST00000071487.6
ENSMUST00000178636.1
Larp1

La ribonucleoprotein domain family, member 1

chr13_+_67863324 0.318 ENSMUST00000078471.5
BC048507
cDNA sequence BC048507
chr9_-_109082372 0.245 ENSMUST00000167504.1
Tma7
translational machinery associated 7 homolog (S. cerevisiae)
chr7_+_122289297 0.244 ENSMUST00000064989.5
ENSMUST00000064921.4
Prkcb

protein kinase C, beta

chr11_+_87737530 0.237 ENSMUST00000093955.5
Supt4a
suppressor of Ty 4A
chr7_-_29232478 0.178 ENSMUST00000085818.4
Kcnk6
potassium inwardly-rectifying channel, subfamily K, member 6
chr15_+_100353149 0.174 ENSMUST00000088142.5
ENSMUST00000176287.1
ENSMUST00000075675.5
Mettl7a2

AB099516
methyltransferase like 7A2

cDNA sequence AB099516
chr11_-_94549165 0.140 ENSMUST00000040487.3
Rsad1
radical S-adenosyl methionine domain containing 1
chr8_-_122476036 0.135 ENSMUST00000014614.3
Rnf166
ring finger protein 166
chr15_+_100334929 0.125 ENSMUST00000075420.4
Mettl7a3
methyltransferase like 7A3
chr3_-_65529355 0.123 ENSMUST00000099076.3
4931440P22Rik
RIKEN cDNA 4931440P22 gene
chr8_+_119910792 0.119 ENSMUST00000108988.2
ENSMUST00000108982.4
ENSMUST00000127664.1
Usp10

Gm20388
ubiquitin specific peptidase 10

predicted gene 20388
chr18_+_77065195 0.118 ENSMUST00000114777.2
Pias2
protein inhibitor of activated STAT 2
chr11_+_76179658 0.072 ENSMUST00000129853.1
ENSMUST00000179223.1
Fam57a
Fam57a
family with sequence similarity 57, member A
family with sequence similarity 57, member A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 1.6 GO:1902460 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
1.4 5.8 GO:0060032 notochord regression(GO:0060032)
1.3 3.8 GO:0072076 hyaluranon cable assembly(GO:0036118) nephrogenic mesenchyme development(GO:0072076) negative regulation of glomerular mesangial cell proliferation(GO:0072125) negative regulation of glomerulus development(GO:0090194) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
1.2 3.7 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892) dermatome development(GO:0061054) regulation of dermatome development(GO:0061183) negative regulation of dopaminergic neuron differentiation(GO:1904339) regulation of cardiac cell fate specification(GO:2000043)
1.2 4.7 GO:0051311 spindle assembly involved in female meiosis(GO:0007056) meiotic metaphase plate congression(GO:0051311)
1.1 4.5 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.7 3.4 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.7 2.0 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) DNA replication preinitiation complex assembly(GO:0071163) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.7 2.0 GO:0019405 alditol catabolic process(GO:0019405) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.7 2.0 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.6 5.8 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.5 1.5 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.5 1.5 GO:0038145 macrophage colony-stimulating factor signaling pathway(GO:0038145) regulation of interleukin-6-mediated signaling pathway(GO:0070103) negative regulation of interleukin-6-mediated signaling pathway(GO:0070104)
0.5 4.2 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.5 1.4 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
0.4 1.3 GO:2000564 CD8-positive, alpha-beta T cell proliferation(GO:0035740) negative regulation of regulatory T cell differentiation(GO:0045590) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564)
0.4 3.6 GO:0090527 actin filament reorganization(GO:0090527)
0.4 1.1 GO:2001160 regulation of histone H3-K79 methylation(GO:2001160)
0.3 1.0 GO:0060023 soft palate development(GO:0060023)
0.3 2.5 GO:0046645 positive regulation of gamma-delta T cell differentiation(GO:0045588) positive regulation of gamma-delta T cell activation(GO:0046645) positive regulation of uterine smooth muscle contraction(GO:0070474)
0.3 0.8 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.3 1.3 GO:0019230 proprioception(GO:0019230)
0.3 4.8 GO:0042347 negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.3 1.8 GO:1904217 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) regulation of serine C-palmitoyltransferase activity(GO:1904220) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.2 0.6 GO:0030070 insulin processing(GO:0030070)
0.2 2.5 GO:0070445 oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.2 2.4 GO:0018065 protein-cofactor linkage(GO:0018065)
0.2 1.3 GO:0072697 protein localization to cell cortex(GO:0072697)
0.2 0.9 GO:0061073 ciliary body morphogenesis(GO:0061073)
0.2 1.3 GO:0051503 adenine nucleotide transport(GO:0051503)
0.2 2.1 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.2 3.4 GO:0030903 notochord development(GO:0030903)
0.2 2.0 GO:0001675 acrosome assembly(GO:0001675)
0.2 5.6 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.2 0.8 GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.1 6.7 GO:1902476 chloride transmembrane transport(GO:1902476)
0.1 2.0 GO:0050965 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.1 0.4 GO:1901355 response to rapamycin(GO:1901355)
0.1 0.4 GO:0090472 dibasic protein processing(GO:0090472)
0.1 0.7 GO:0035754 B cell chemotaxis(GO:0035754)
0.1 3.1 GO:0060445 branching involved in salivary gland morphogenesis(GO:0060445)
0.1 0.5 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.1 0.5 GO:0002756 MyD88-independent toll-like receptor signaling pathway(GO:0002756)
0.1 2.5 GO:0048255 mRNA stabilization(GO:0048255)
0.1 0.7 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.2 GO:0035405 histone-threonine phosphorylation(GO:0035405) positive regulation of B cell receptor signaling pathway(GO:0050861)
0.0 0.7 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.2 GO:0060075 regulation of resting membrane potential(GO:0060075)
0.0 0.9 GO:0006783 heme biosynthetic process(GO:0006783)
0.0 0.3 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.0 0.7 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.5 GO:0016188 synaptic vesicle maturation(GO:0016188)
0.0 0.6 GO:0016180 snRNA processing(GO:0016180)
0.0 0.6 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.2 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.0 0.1 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
0.0 0.4 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.7 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.0 0.3 GO:0000305 response to oxygen radical(GO:0000305)
0.0 1.2 GO:0045740 positive regulation of DNA replication(GO:0045740)
0.0 1.7 GO:0006909 phagocytosis(GO:0006909)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 8.7 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
1.2 3.6 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
1.2 4.8 GO:0043293 apoptosome(GO:0043293)
1.1 3.4 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.7 4.2 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.7 2.0 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.5 4.7 GO:0072687 meiotic spindle(GO:0072687)
0.5 1.9 GO:0043259 laminin-10 complex(GO:0043259)
0.4 5.8 GO:0097542 ciliary tip(GO:0097542)
0.3 1.2 GO:1990590 ATF1-ATF4 transcription factor complex(GO:1990590)
0.1 1.5 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 2.5 GO:0000242 pericentriolar material(GO:0000242)
0.1 2.0 GO:0002080 acrosomal membrane(GO:0002080)
0.1 2.1 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 0.7 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 0.6 GO:0005916 fascia adherens(GO:0005916)
0.0 0.6 GO:0031045 dense core granule(GO:0031045)
0.0 0.6 GO:0032039 integrator complex(GO:0032039)
0.0 2.9 GO:0005844 polysome(GO:0005844)
0.0 5.6 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 1.3 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.4 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 0.6 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 1.5 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 2.9 GO:0005884 actin filament(GO:0005884)
0.0 2.4 GO:0000793 condensed chromosome(GO:0000793)
0.0 6.8 GO:0031012 extracellular matrix(GO:0031012)
0.0 2.9 GO:0005759 mitochondrial matrix(GO:0005759)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 8.7 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
1.4 4.2 GO:0004774 succinate-CoA ligase activity(GO:0004774)
1.2 3.7 GO:0005110 frizzled-2 binding(GO:0005110)
0.5 5.6 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.5 2.5 GO:0042610 CD8 receptor binding(GO:0042610)
0.5 1.5 GO:0097677 STAT family protein binding(GO:0097677)
0.5 1.4 GO:0071936 coreceptor activity involved in Wnt signaling pathway(GO:0071936)
0.5 3.6 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.4 1.3 GO:0046964 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity(GO:0046964)
0.4 3.4 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.4 2.4 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.4 3.8 GO:0070700 BMP receptor binding(GO:0070700)
0.3 4.0 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.3 1.3 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.2 4.5 GO:0003746 translation elongation factor activity(GO:0003746)
0.2 2.0 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.2 3.4 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.2 1.4 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.2 0.5 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.1 2.0 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 0.4 GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597)
0.1 0.7 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.1 1.8 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.1 0.7 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.1 1.9 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 3.5 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 0.8 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.1 0.8 GO:0001972 retinoic acid binding(GO:0001972)
0.1 0.6 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.1 1.6 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.1 0.6 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.1 0.4 GO:0008494 translation activator activity(GO:0008494)
0.1 2.1 GO:0005109 frizzled binding(GO:0005109)
0.1 2.4 GO:0045182 translation regulator activity(GO:0045182)
0.1 1.3 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.6 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 2.1 GO:0004407 histone deacetylase activity(GO:0004407)
0.0 1.5 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.2 GO:0035184 histone threonine kinase activity(GO:0035184)
0.0 0.4 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 2.0 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0 1.0 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.7 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 2.0 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 3.1 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.7 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.9 GO:0005112 Notch binding(GO:0005112)
0.0 1.0 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 1.9 GO:0005178 integrin binding(GO:0005178)
0.0 1.9 GO:0008201 heparin binding(GO:0008201)
0.0 0.1 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.2 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.5 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.1 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.0 0.3 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 0.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 1.2 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 4.7 GO:0005525 GTP binding(GO:0005525)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.8 PID_ALK2_PATHWAY ALK2 signaling events
0.2 1.9 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.2 5.2 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 3.8 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 2.5 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway
0.1 4.7 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 2.7 PID_IFNG_PATHWAY IFN-gamma pathway
0.1 0.7 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 2.0 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 1.9 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 2.0 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.3 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 1.2 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.0 0.2 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 2.1 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.0 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.8 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 0.1 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 0.9 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.9 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.6 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B
0.0 0.5 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.6 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.5 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.3 2.7 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.2 4.2 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 2.0 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.1 1.5 REACTOME_REGULATION_OF_IFNG_SIGNALING Genes involved in Regulation of IFNG signaling
0.1 1.6 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 3.4 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 2.4 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 0.7 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 0.9 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1 5.9 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.3 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 1.9 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.1 1.4 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.1 1.5 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 2.0 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.4 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 0.7 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.6 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 2.0 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.2 REACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION Genes involved in Nuclear Events (kinase and transcription factor activation)
0.0 1.3 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 1.3 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.6 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.2 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 1.9 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.8 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.0 1.0 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.6 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 0.8 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.2 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors