Motif ID: Tbx4

Z-value: 1.100


Transcription factors associated with Tbx4:

Gene SymbolEntrez IDGene Name
Tbx4 ENSMUSG00000000094.6 Tbx4



Activity profile for motif Tbx4.

activity profile for motif Tbx4


Sorted Z-values histogram for motif Tbx4

Sorted Z-values for motif Tbx4



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_26229707 18.424 ENSMUST00000060716.5
ENSMUST00000164660.1
Samd3

sterile alpha motif domain containing 3

chr2_+_164562579 12.570 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
Wfdc2


WAP four-disulfide core domain 2


chr1_-_138847579 9.297 ENSMUST00000093486.3
ENSMUST00000046870.6
Lhx9

LIM homeobox protein 9

chr9_-_43239816 9.285 ENSMUST00000034512.5
Oaf
OAF homolog (Drosophila)
chr17_+_29093763 9.276 ENSMUST00000023829.6
Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr1_+_6730051 9.256 ENSMUST00000043578.6
ENSMUST00000131467.1
ENSMUST00000150761.1
ENSMUST00000151281.1
St18



suppression of tumorigenicity 18



chr14_-_70642268 9.042 ENSMUST00000022697.5
Fgf17
fibroblast growth factor 17
chr10_-_120899067 8.345 ENSMUST00000092143.5
Msrb3
methionine sulfoxide reductase B3
chr2_-_13011747 7.707 ENSMUST00000061545.5
C1ql3
C1q-like 3
chr6_+_7555053 6.984 ENSMUST00000090679.2
ENSMUST00000184986.1
Tac1

tachykinin 1

chr4_-_134018829 6.114 ENSMUST00000051674.2
Lin28a
lin-28 homolog A (C. elegans)
chr6_-_94700137 5.715 ENSMUST00000101126.2
ENSMUST00000032105.4
Lrig1

leucine-rich repeats and immunoglobulin-like domains 1

chr12_+_3891728 5.531 ENSMUST00000172689.1
ENSMUST00000111186.1
Dnmt3a

DNA methyltransferase 3A

chr6_+_15196949 5.329 ENSMUST00000151301.1
ENSMUST00000131414.1
ENSMUST00000140557.1
ENSMUST00000115469.1
Foxp2



forkhead box P2



chr7_-_28302238 5.249 ENSMUST00000108315.3
Dll3
delta-like 3 (Drosophila)
chr19_+_20601958 5.165 ENSMUST00000087638.3
Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
chr2_-_57114970 4.984 ENSMUST00000028166.2
Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr1_+_6730135 4.801 ENSMUST00000155921.1
St18
suppression of tumorigenicity 18
chr18_-_46212595 4.405 ENSMUST00000037011.4
Trim36
tripartite motif-containing 36
chrX_-_53269020 4.319 ENSMUST00000114838.1
Fam122b
family with sequence similarity 122, member B
chrX_+_100729917 3.889 ENSMUST00000019503.7
Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chr5_+_115908644 3.765 ENSMUST00000141101.1
Cit
citron
chr9_-_95845215 3.631 ENSMUST00000093800.2
Pls1
plastin 1 (I-isoform)
chr4_+_11191726 3.540 ENSMUST00000029866.9
ENSMUST00000108324.3
Ccne2

cyclin E2

chrX_+_100730178 3.511 ENSMUST00000113744.1
Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chr1_+_153665666 3.370 ENSMUST00000111814.1
ENSMUST00000111810.1
Rgs8

regulator of G-protein signaling 8

chr1_+_153665274 3.296 ENSMUST00000152114.1
ENSMUST00000111812.1
Rgs8

regulator of G-protein signaling 8

chr1_+_132316112 3.152 ENSMUST00000082125.5
ENSMUST00000072177.7
Nuak2

NUAK family, SNF1-like kinase, 2

chr9_+_35421541 3.039 ENSMUST00000119129.2
Cdon
cell adhesion molecule-related/down-regulated by oncogenes
chr6_-_24956106 2.597 ENSMUST00000127247.2
Tmem229a
transmembrane protein 229A
chr11_-_94507337 2.505 ENSMUST00000040692.8
Mycbpap
MYCBP associated protein
chr15_-_38300693 2.484 ENSMUST00000074043.5
Klf10
Kruppel-like factor 10
chr1_+_153665627 2.473 ENSMUST00000147482.1
Rgs8
regulator of G-protein signaling 8
chr1_+_153665587 2.313 ENSMUST00000147700.1
Rgs8
regulator of G-protein signaling 8
chr14_+_62292475 2.261 ENSMUST00000166879.1
Rnaseh2b
ribonuclease H2, subunit B
chr10_-_86705485 2.214 ENSMUST00000020238.7
Hsp90b1
heat shock protein 90, beta (Grp94), member 1
chr4_+_117849361 2.212 ENSMUST00000163288.1
Slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr13_-_89742490 2.065 ENSMUST00000109546.2
Vcan
versican
chr13_-_96542479 2.046 ENSMUST00000022172.4
Polk
polymerase (DNA directed), kappa
chr7_-_141443989 2.028 ENSMUST00000026580.5
Lrdd
leucine-rich and death domain containing
chr11_-_115813621 1.960 ENSMUST00000041684.4
ENSMUST00000156812.1
Caskin2

CASK-interacting protein 2

chr7_-_115824699 1.947 ENSMUST00000169129.1
Sox6
SRY-box containing gene 6
chr4_+_11191354 1.861 ENSMUST00000170901.1
Ccne2
cyclin E2
chr2_+_103970221 1.775 ENSMUST00000111140.2
ENSMUST00000111139.2
Lmo2

LIM domain only 2

chr7_-_100658394 1.770 ENSMUST00000138830.1
ENSMUST00000107044.3
ENSMUST00000116287.2
Plekhb1


pleckstrin homology domain containing, family B (evectins) member 1


chr3_+_51415986 1.768 ENSMUST00000029303.7
Naa15
N(alpha)-acetyltransferase 15, NatA auxiliary subunit
chr2_+_103970115 1.650 ENSMUST00000111143.1
ENSMUST00000138815.1
Lmo2

LIM domain only 2

chr2_-_148046896 1.637 ENSMUST00000172928.1
ENSMUST00000047315.3
Foxa2

forkhead box A2

chr11_+_78178105 1.544 ENSMUST00000147819.1
Tlcd1
TLC domain containing 1
chrM_+_9452 1.539 ENSMUST00000082411.1
mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chr4_+_117849193 1.451 ENSMUST00000132043.2
ENSMUST00000169990.1
Slc6a9

solute carrier family 6 (neurotransmitter transporter, glycine), member 9

chr19_+_55894508 1.434 ENSMUST00000142291.1
Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr9_-_69760924 1.342 ENSMUST00000071281.4
Foxb1
forkhead box B1
chr19_-_42202150 1.338 ENSMUST00000018966.7
Sfrp5
secreted frizzled-related sequence protein 5
chr15_-_10470490 1.318 ENSMUST00000136591.1
Dnajc21
DnaJ (Hsp40) homolog, subfamily C, member 21
chr12_-_56345862 1.316 ENSMUST00000021416.7
Mbip
MAP3K12 binding inhibitory protein 1
chrX_+_42151002 1.260 ENSMUST00000123245.1
Stag2
stromal antigen 2
chr4_-_36056726 1.257 ENSMUST00000108124.3
Lingo2
leucine rich repeat and Ig domain containing 2
chr3_-_75556759 1.237 ENSMUST00000162138.1
ENSMUST00000029424.5
ENSMUST00000161137.1
Pdcd10


programmed cell death 10


chr3_+_96629919 1.146 ENSMUST00000048915.6
Rbm8a
RNA binding motif protein 8a
chr4_-_72852622 1.126 ENSMUST00000179234.1
ENSMUST00000078617.4
Aldoart1

aldolase 1 A, retrogene 1

chr2_-_148045891 1.120 ENSMUST00000109964.1
Foxa2
forkhead box A2
chr4_-_42168603 1.101 ENSMUST00000098121.3
Gm13305
predicted gene 13305
chr9_+_48495345 1.094 ENSMUST00000048824.7
Gm5617
predicted gene 5617
chr15_+_10952332 1.092 ENSMUST00000022853.8
ENSMUST00000110523.1
C1qtnf3

C1q and tumor necrosis factor related protein 3

chr13_+_93304066 1.073 ENSMUST00000109493.1
Homer1
homer homolog 1 (Drosophila)
chr11_-_22286795 1.015 ENSMUST00000109563.2
ENSMUST00000180360.1
Ehbp1

EH domain binding protein 1

chr11_-_78751656 0.961 ENSMUST00000059468.4
Fam58b
family with sequence similarity 58, member B
chr10_-_85916902 0.961 ENSMUST00000037646.7
Prdm4
PR domain containing 4
chr16_-_84835484 0.949 ENSMUST00000114191.1
Atp5j
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F
chr5_+_120513102 0.914 ENSMUST00000111889.1
Slc8b1
solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
chr7_-_100658364 0.900 ENSMUST00000107043.1
Plekhb1
pleckstrin homology domain containing, family B (evectins) member 1
chr7_-_99858872 0.900 ENSMUST00000036274.6
Spcs2
signal peptidase complex subunit 2 homolog (S. cerevisiae)
chr2_+_138278481 0.866 ENSMUST00000075410.4
Btbd3
BTB (POZ) domain containing 3
chr12_+_88953399 0.846 ENSMUST00000057634.7
Nrxn3
neurexin III
chrX_+_101383726 0.781 ENSMUST00000119190.1
Gjb1
gap junction protein, beta 1
chr1_+_66468364 0.777 ENSMUST00000061620.9
Unc80
unc-80 homolog (C. elegans)
chr2_+_54436317 0.760 ENSMUST00000112636.1
ENSMUST00000112635.1
ENSMUST00000112634.1
Galnt13


UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13


chr10_-_128211788 0.738 ENSMUST00000061995.8
Spryd4
SPRY domain containing 4
chr13_+_113209659 0.717 ENSMUST00000038144.8
Esm1
endothelial cell-specific molecule 1
chr12_-_31634592 0.689 ENSMUST00000020979.7
ENSMUST00000177962.1
Bcap29

B cell receptor associated protein 29

chr9_-_48495321 0.675 ENSMUST00000170000.2
Rbm7
RNA binding motif protein 7
chr10_-_127341583 0.665 ENSMUST00000026474.3
Gli1
GLI-Kruppel family member GLI1
chr13_-_108158584 0.619 ENSMUST00000163558.1
Ndufaf2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 2
chr4_+_148000722 0.603 ENSMUST00000103230.4
Nppa
natriuretic peptide type A
chrX_+_169036610 0.603 ENSMUST00000087016.4
ENSMUST00000112129.1
ENSMUST00000112131.2
Arhgap6


Rho GTPase activating protein 6


chr7_+_46796088 0.555 ENSMUST00000006774.4
ENSMUST00000165031.1
Gtf2h1

general transcription factor II H, polypeptide 1

chr9_+_44326804 0.537 ENSMUST00000054708.3
Dpagt1
dolichyl-phosphate (UDP-N-acetylglucosamine) acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
chrX_+_20425688 0.510 ENSMUST00000115384.2
Phf16
PHD finger protein 16
chr16_-_9994921 0.469 ENSMUST00000115835.1
Grin2a
glutamate receptor, ionotropic, NMDA2A (epsilon 1)
chr16_+_19028232 0.454 ENSMUST00000074116.4
Gm10088
predicted gene 10088
chr14_+_51893610 0.439 ENSMUST00000047726.5
ENSMUST00000161888.1
Slc39a2

solute carrier family 39 (zinc transporter), member 2

chr14_-_51988829 0.405 ENSMUST00000181008.1
Gm16617
predicted gene, 16617
chr10_+_96136603 0.391 ENSMUST00000074615.6
Gm5426
predicted pseudogene 5426
chr2_-_30178422 0.301 ENSMUST00000100220.4
ENSMUST00000179795.1
D2Wsu81e

DNA segment, Chr 2, Wayne State University 81, expressed

chr9_+_86743641 0.288 ENSMUST00000179574.1
Prss35
protease, serine, 35
chr8_+_45885479 0.245 ENSMUST00000034053.5
Pdlim3
PDZ and LIM domain 3
chr17_-_78937031 0.242 ENSMUST00000024885.8
Cebpz
CCAAT/enhancer binding protein zeta
chr13_-_111490028 0.234 ENSMUST00000091236.4
Gpbp1
GC-rich promoter binding protein 1
chr11_+_95414078 0.227 ENSMUST00000107724.2
ENSMUST00000150884.1
ENSMUST00000107722.1
ENSMUST00000127713.1
Spop



speckle-type POZ protein



chrX_-_162829379 0.225 ENSMUST00000041370.4
ENSMUST00000112316.2
ENSMUST00000112315.1
Txlng


taxilin gamma


chr4_+_84884418 0.212 ENSMUST00000169371.2
Cntln
centlein, centrosomal protein
chr4_+_125490688 0.160 ENSMUST00000030676.7
Grik3
glutamate receptor, ionotropic, kainate 3
chr11_+_78826575 0.112 ENSMUST00000147875.2
ENSMUST00000141321.1
Lyrm9

LYR motif containing 9

chr2_+_106695594 0.084 ENSMUST00000016530.7
Mpped2
metallophosphoesterase domain containing 2
chr11_-_86544754 0.064 ENSMUST00000138810.1
ENSMUST00000058286.2
ENSMUST00000154617.1
Rps6kb1


ribosomal protein S6 kinase, polypeptide 1


chr14_+_31251454 0.060 ENSMUST00000022458.4
Bap1
Brca1 associated protein 1
chr9_+_108296853 0.055 ENSMUST00000035230.5
Amt
aminomethyltransferase
chr4_-_46404224 0.041 ENSMUST00000107764.2
Hemgn
hemogen
chr6_+_83054653 0.035 ENSMUST00000092618.6
Aup1
ancient ubiquitous protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 7.0 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
2.1 8.3 GO:0030091 protein repair(GO:0030091)
1.9 5.7 GO:0032474 otolith morphogenesis(GO:0032474)
1.9 9.3 GO:0035262 gonad morphogenesis(GO:0035262)
1.7 5.0 GO:0051866 general adaptation syndrome(GO:0051866)
1.3 5.2 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
1.2 3.7 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
1.2 3.6 GO:0001951 intestinal D-glucose absorption(GO:0001951) terminal web assembly(GO:1902896)
1.2 14.1 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
1.0 5.2 GO:0007386 compartment pattern specification(GO:0007386)
1.0 9.3 GO:0071493 cellular response to UV-B(GO:0071493)
0.9 2.8 GO:0045014 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) detection of glucose(GO:0051594)
0.8 7.4 GO:0090527 actin filament reorganization(GO:0090527)
0.8 11.5 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.7 5.5 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.7 6.1 GO:0010587 miRNA catabolic process(GO:0010587)
0.4 1.3 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.4 5.3 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.4 1.2 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.3 1.3 GO:0007412 axon target recognition(GO:0007412)
0.3 2.0 GO:0006297 nucleotide-excision repair, DNA gap filling(GO:0006297)
0.3 1.1 GO:0071638 negative regulation of monocyte chemotactic protein-1 production(GO:0071638)
0.3 3.4 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.3 1.8 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.2 0.7 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.2 1.3 GO:0051189 molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.2 3.0 GO:0043497 regulation of protein heterodimerization activity(GO:0043497)
0.2 2.2 GO:0071318 cellular response to ATP(GO:0071318)
0.2 3.8 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.2 0.7 GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
0.2 1.4 GO:0048625 myoblast fate commitment(GO:0048625)
0.2 1.9 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.2 0.7 GO:0060032 notochord regression(GO:0060032)
0.2 1.3 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.2 3.9 GO:0007340 acrosome reaction(GO:0007340)
0.2 0.6 GO:1903764 regulation of potassium ion export across plasma membrane(GO:1903764)
0.1 5.4 GO:0007129 synapsis(GO:0007129)
0.1 2.0 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.1 9.0 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
0.1 2.3 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.1 1.0 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.1 3.2 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.1 0.5 GO:0019348 dolichol metabolic process(GO:0019348)
0.1 0.5 GO:0071294 cellular response to zinc ion(GO:0071294)
0.1 0.6 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.1 10.6 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.1 0.9 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.6 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.0 0.8 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.0 1.6 GO:0071385 cellular response to glucocorticoid stimulus(GO:0071385)
0.0 0.2 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.0 0.6 GO:0007202 activation of phospholipase C activity(GO:0007202)
0.0 2.1 GO:0008347 glial cell migration(GO:0008347)
0.0 1.8 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 2.7 GO:0030282 bone mineralization(GO:0030282)
0.0 4.7 GO:0050807 regulation of synapse organization(GO:0050807)
0.0 0.9 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.1 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.0 0.2 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 0.8 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.0 0.1 GO:0035521 monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.0 0.4 GO:0006829 zinc II ion transport(GO:0006829)
0.0 1.0 GO:2000177 regulation of neural precursor cell proliferation(GO:2000177)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 9.3 GO:0070557 PCNA-p21 complex(GO:0070557)
1.8 5.4 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.7 3.6 GO:1990357 terminal web(GO:1990357)
0.4 2.3 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.3 11.5 GO:0032809 neuronal cell body membrane(GO:0032809)
0.2 1.8 GO:0031415 NatA complex(GO:0031415)
0.2 5.5 GO:0001741 XY body(GO:0001741)
0.2 2.2 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.2 1.4 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 8.8 GO:0005581 collagen trimer(GO:0005581)
0.1 0.9 GO:0005787 signal peptidase complex(GO:0005787)
0.1 6.1 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 1.1 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 0.6 GO:0042629 mast cell granule(GO:0042629)
0.1 1.3 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 12.2 GO:0032993 protein-DNA complex(GO:0032993)
0.1 0.6 GO:0000439 core TFIIH complex(GO:0000439)
0.1 3.8 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 0.9 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 0.9 GO:0030061 mitochondrial crista(GO:0030061)
0.1 0.8 GO:0005922 connexon complex(GO:0005922)
0.1 0.7 GO:0097542 ciliary tip(GO:0097542)
0.0 7.4 GO:0005884 actin filament(GO:0005884)
0.0 2.7 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 1.1 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 2.6 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.5 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 1.1 GO:0043034 costamere(GO:0043034)
0.0 1.0 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.9 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 1.1 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.0 GO:0035097 histone methyltransferase complex(GO:0035097)
0.0 5.0 GO:0005667 transcription factor complex(GO:0005667)
0.0 3.3 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 4.5 GO:0098793 presynapse(GO:0098793)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 9.3 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
3.0 9.0 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
2.5 12.6 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
1.4 8.3 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
1.0 5.2 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.9 7.4 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.7 5.5 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.6 6.1 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.4 7.6 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.4 3.7 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.3 2.3 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.3 11.5 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.3 2.2 GO:0046790 virion binding(GO:0046790)
0.2 0.7 GO:0005171 hepatocyte growth factor receptor binding(GO:0005171)
0.2 0.9 GO:0086038 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038)
0.2 6.4 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.2 5.0 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 5.2 GO:0005112 Notch binding(GO:0005112)
0.1 0.5 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.1 1.8 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.1 2.1 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 1.3 GO:0016783 sulfurtransferase activity(GO:0016783)
0.1 1.1 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.1 3.4 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.1 18.9 GO:0001047 core promoter binding(GO:0001047)
0.1 2.0 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 1.0 GO:1990226 histone methyltransferase binding(GO:1990226)
0.1 0.8 GO:0005243 gap junction channel activity(GO:0005243)
0.1 0.6 GO:0016004 phospholipase activator activity(GO:0016004) lipase activator activity(GO:0060229)
0.1 1.3 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 4.2 GO:0097110 scaffold protein binding(GO:0097110)
0.1 0.8 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 1.4 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 7.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.6 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.2 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.0 0.1 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 0.8 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 3.6 GO:0051015 actin filament binding(GO:0051015)
0.0 0.4 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.2 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 3.2 GO:0000287 magnesium ion binding(GO:0000287)
0.0 2.7 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 0.9 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 1.2 GO:0047485 protein N-terminus binding(GO:0047485)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 9.3 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.4 5.4 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 5.1 PID_ERBB4_PATHWAY ErbB4 signaling events
0.1 7.2 PID_FGF_PATHWAY FGF signaling pathway
0.1 3.0 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 2.8 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 3.7 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 5.5 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 3.8 PID_RHOA_PATHWAY RhoA signaling pathway
0.1 5.2 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 2.2 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 0.2 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.3 PID_PLK1_PATHWAY PLK1 signaling events
0.0 0.9 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.4 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.5 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 0.7 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 0.6 PID_RHOA_REG_PATHWAY Regulation of RhoA activity

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 5.2 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
1.1 9.0 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.4 3.7 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.3 9.3 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.2 2.2 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR
0.2 5.4 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.2 2.8 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.1 2.1 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.1 11.5 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 0.9 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1 7.0 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 3.0 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 5.0 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 0.8 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.1 0.9 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 1.1 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.0 0.4 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.6 REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER Genes involved in Formation of incision complex in GG-NER
0.0 0.6 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.5 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 0.8 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.5 REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 1.3 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.0 4.4 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.2 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors