Motif ID: Six6

Z-value: 0.437


Transcription factors associated with Six6:

Gene SymbolEntrez IDGene Name
Six6 ENSMUSG00000021099.5 Six6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Six6mm10_v2_chr12_+_72939724_72939758-0.211.9e-01Click!


Activity profile for motif Six6.

activity profile for motif Six6


Sorted Z-values histogram for motif Six6

Sorted Z-values for motif Six6



Network of associatons between targets according to the STRING database.



First level regulatory network of Six6

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_140607334 2.479 ENSMUST00000031555.1
Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr11_+_78324200 2.398 ENSMUST00000102478.3
Aldoc
aldolase C, fructose-bisphosphate
chr9_+_98422961 1.873 ENSMUST00000052068.9
Rbp1
retinol binding protein 1, cellular
chr6_-_23248264 1.806 ENSMUST00000031709.5
Fezf1
Fez family zinc finger 1
chr11_+_98412461 1.767 ENSMUST00000058295.5
Erbb2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
chr14_+_67234620 1.395 ENSMUST00000176029.1
Ebf2
early B cell factor 2
chr4_-_97584605 1.225 ENSMUST00000107067.1
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr4_-_97584612 1.167 ENSMUST00000107068.2
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr8_-_94918012 1.011 ENSMUST00000077955.5
Ccdc102a
coiled-coil domain containing 102A
chr1_+_45311538 0.902 ENSMUST00000087883.6
Col3a1
collagen, type III, alpha 1
chr4_-_43653542 0.891 ENSMUST00000084646.4
Spag8
sperm associated antigen 8
chr7_+_46847128 0.881 ENSMUST00000005051.4
Ldha
lactate dehydrogenase A
chr4_+_156013835 0.853 ENSMUST00000030952.5
Tnfrsf4
tumor necrosis factor receptor superfamily, member 4
chrX_-_142966709 0.848 ENSMUST00000041317.2
Ammecr1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr15_-_82244716 0.818 ENSMUST00000089155.4
ENSMUST00000089157.3
Cenpm

centromere protein M

chr8_+_40423786 0.807 ENSMUST00000049389.4
ENSMUST00000128166.1
ENSMUST00000167766.1
Zdhhc2


zinc finger, DHHC domain containing 2


chr4_-_43653560 0.804 ENSMUST00000107870.2
Spag8
sperm associated antigen 8
chr10_+_24595623 0.764 ENSMUST00000176228.1
ENSMUST00000129142.1
Ctgf

connective tissue growth factor

chr12_+_52097737 0.733 ENSMUST00000040090.9
Nubpl
nucleotide binding protein-like
chr8_+_69832633 0.672 ENSMUST00000131637.2
ENSMUST00000081503.6
Pbx4

pre B cell leukemia homeobox 4

chr8_+_85026833 0.667 ENSMUST00000047281.8
2310036O22Rik
RIKEN cDNA 2310036O22 gene
chr5_+_144244432 0.657 ENSMUST00000110695.1
Bri3
brain protein I3
chr8_-_106573461 0.653 ENSMUST00000073722.5
Gm10073
predicted pseudogene 10073
chr3_+_130068390 0.633 ENSMUST00000076703.6
Gm9396
predicted gene 9396
chr1_+_74713551 0.627 ENSMUST00000027356.5
Cyp27a1
cytochrome P450, family 27, subfamily a, polypeptide 1
chr7_-_42578588 0.600 ENSMUST00000179470.1
Gm21028
predicted gene, 21028
chr1_-_165708088 0.599 ENSMUST00000040357.8
ENSMUST00000097474.3
Rcsd1

RCSD domain containing 1

chr19_-_53589067 0.586 ENSMUST00000095978.3
Nutf2-ps1
nuclear transport factor 2, pseudogene 1
chr18_+_35553401 0.580 ENSMUST00000181664.1
Snhg4
small nucleolar RNA host gene 4 (non-protein coding)
chr16_+_84774123 0.576 ENSMUST00000114195.1
Jam2
junction adhesion molecule 2
chr7_+_30232310 0.552 ENSMUST00000108193.1
ENSMUST00000108192.1
Polr2i

polymerase (RNA) II (DNA directed) polypeptide I

chr10_+_128238034 0.548 ENSMUST00000105245.2
Timeless
timeless circadian clock 1
chr3_-_37724321 0.543 ENSMUST00000108105.1
ENSMUST00000079755.4
ENSMUST00000099128.1
Gm5148


predicted gene 5148


chr10_-_128180265 0.538 ENSMUST00000099139.1
Rbms2
RNA binding motif, single stranded interacting protein 2
chr18_-_88927447 0.532 ENSMUST00000147313.1
Socs6
suppressor of cytokine signaling 6
chr2_+_106693185 0.529 ENSMUST00000111063.1
Mpped2
metallophosphoesterase domain containing 2
chr8_+_84831522 0.519 ENSMUST00000036734.5
Gadd45gip1
growth arrest and DNA-damage-inducible, gamma interacting protein 1
chr7_-_130547358 0.502 ENSMUST00000160289.1
Nsmce4a
non-SMC element 4 homolog A (S. cerevisiae)
chrX_-_74373260 0.500 ENSMUST00000073067.4
ENSMUST00000037967.5
Slc10a3

solute carrier family 10 (sodium/bile acid cotransporter family), member 3

chr11_+_115564434 0.498 ENSMUST00000021085.4
Nup85
nucleoporin 85
chr18_+_56432116 0.497 ENSMUST00000070166.5
Gramd3
GRAM domain containing 3
chrX_+_103414461 0.494 ENSMUST00000033691.4
Tsx
testis specific X-linked gene
chr19_+_4154606 0.481 ENSMUST00000061086.8
Ptprcap
protein tyrosine phosphatase, receptor type, C polypeptide-associated protein
chr7_-_101903783 0.479 ENSMUST00000106969.1
Tomt
transmembrane O-methyltransferase
chr11_+_100319880 0.477 ENSMUST00000049385.7
Eif1
eukaryotic translation initiation factor 1
chr7_+_128062657 0.458 ENSMUST00000120355.1
ENSMUST00000106240.2
ENSMUST00000098015.3
Itgam


integrin alpha M


chr9_-_114564315 0.458 ENSMUST00000111816.2
Trim71
tripartite motif-containing 71
chr19_-_5729618 0.450 ENSMUST00000116558.2
ENSMUST00000099955.3
ENSMUST00000161368.1
Fam89b


family with sequence similarity 89, member B


chr16_-_65562686 0.436 ENSMUST00000004965.6
Chmp2b
charged multivesicular body protein 2B
chr7_-_35647127 0.423 ENSMUST00000120714.1
Pdcd5
programmed cell death 5
chr18_+_14424821 0.420 ENSMUST00000069552.5
Gm5160
predicted gene 5160
chr17_-_53539411 0.413 ENSMUST00000056198.3
Pp2d1
protein phosphatase 2C-like domain containing 1
chr17_-_62606679 0.405 ENSMUST00000163332.1
Efna5
ephrin A5
chr16_+_10835046 0.404 ENSMUST00000037913.8
Rmi2
RMI2, RecQ mediated genome instability 2, homolog (S. cerevisiae)
chr14_+_58893465 0.397 ENSMUST00000079960.1
Rpl13-ps3
ribosomal protein L13, pseudogene 3
chr5_+_117319258 0.393 ENSMUST00000111967.1
Vsig10
V-set and immunoglobulin domain containing 10
chr7_+_30231884 0.378 ENSMUST00000019882.9
Polr2i
polymerase (RNA) II (DNA directed) polypeptide I
chr3_+_88207308 0.360 ENSMUST00000180582.1
Gm3764
predicted gene 3764
chr9_-_121839460 0.352 ENSMUST00000135986.2
Ccdc13
coiled-coil domain containing 13
chr1_-_128359610 0.351 ENSMUST00000027601.4
Mcm6
minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)
chr12_+_84773262 0.345 ENSMUST00000021667.5
Isca2
iron-sulfur cluster assembly 2 homolog (S. cerevisiae)
chr17_+_35241838 0.340 ENSMUST00000173731.1
Ddx39b
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr11_-_102365111 0.340 ENSMUST00000006749.9
Slc4a1
solute carrier family 4 (anion exchanger), member 1
chr13_+_65512678 0.339 ENSMUST00000081471.2
Gm10139
predicted gene 10139
chr5_+_104046869 0.337 ENSMUST00000031250.7
Nudt9
nudix (nucleoside diphosphate linked moiety X)-type motif 9
chrY_-_6237995 0.332 ENSMUST00000177612.1
Gm21746
predicted gene, 21746
chr1_+_171419027 0.331 ENSMUST00000171362.1
Tstd1
thiosulfate sulfurtransferase (rhodanese)-like domain containing 1
chr3_+_108571699 0.326 ENSMUST00000143054.1
Taf13
TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr5_+_123907175 0.318 ENSMUST00000023869.8
Denr
density-regulated protein
chrX_-_74373218 0.311 ENSMUST00000178691.1
ENSMUST00000114146.1
Ubl4
Slc10a3
ubiquitin-like 4
solute carrier family 10 (sodium/bile acid cotransporter family), member 3
chr19_-_4625612 0.307 ENSMUST00000025823.3
Rce1
RCE1 homolog, prenyl protein peptidase (S. cerevisiae)
chrX_+_169685191 0.306 ENSMUST00000112104.1
ENSMUST00000112107.1
Mid1

midline 1

chr13_-_66852017 0.303 ENSMUST00000059329.6
Gm17449
predicted gene, 17449
chr15_+_98571004 0.302 ENSMUST00000023728.6
4930415O20Rik
RIKEN cDNA 4930415O20 gene
chrM_+_2743 0.298 ENSMUST00000082392.1
mt-Nd1
mitochondrially encoded NADH dehydrogenase 1
chr13_-_66227573 0.298 ENSMUST00000167981.2
Gm10772
predicted gene 10772
chr5_+_21543525 0.290 ENSMUST00000035651.4
Lrrc17
leucine rich repeat containing 17
chr5_-_88527841 0.288 ENSMUST00000087033.3
Igj
immunoglobulin joining chain
chr17_+_40811089 0.285 ENSMUST00000024721.7
Rhag
Rhesus blood group-associated A glycoprotein
chr7_+_43690418 0.281 ENSMUST00000056329.6
Klk14
kallikrein related-peptidase 14
chr17_-_27909206 0.279 ENSMUST00000114848.1
Taf11
TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr17_+_35241746 0.275 ENSMUST00000068056.5
ENSMUST00000174757.1
Ddx39b

DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B

chr5_+_140419248 0.262 ENSMUST00000100507.3
Eif3b
eukaryotic translation initiation factor 3, subunit B
chr19_-_55315980 0.258 ENSMUST00000076891.5
Zdhhc6
zinc finger, DHHC domain containing 6
chr5_+_121204477 0.255 ENSMUST00000031617.9
Rpl6
ribosomal protein L6
chr8_-_4275886 0.255 ENSMUST00000003029.7
Timm44
translocase of inner mitochondrial membrane 44
chr6_-_50382831 0.254 ENSMUST00000114468.2
Osbpl3
oxysterol binding protein-like 3
chr15_-_75894474 0.253 ENSMUST00000023237.6
Naprt1
nicotinate phosphoribosyltransferase domain containing 1
chr19_-_11336107 0.251 ENSMUST00000056035.2
ENSMUST00000067532.4
Ms4a7

membrane-spanning 4-domains, subfamily A, member 7

chr19_+_8764934 0.247 ENSMUST00000184663.1
Nxf1
nuclear RNA export factor 1
chr11_-_106272927 0.237 ENSMUST00000021052.9
Smarcd2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
chr6_+_54264839 0.237 ENSMUST00000146114.1
Chn2
chimerin (chimaerin) 2
chr17_+_56717759 0.235 ENSMUST00000002452.6
Ndufa11
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 11
chr12_+_105705970 0.231 ENSMUST00000040876.5
Ak7
adenylate kinase 7
chr9_-_66975387 0.221 ENSMUST00000034929.6
Lactb
lactamase, beta
chr6_-_81965925 0.218 ENSMUST00000032124.8
Mrpl19
mitochondrial ribosomal protein L19
chr19_-_4042165 0.215 ENSMUST00000042700.9
Gstp2
glutathione S-transferase, pi 2
chr16_-_31275277 0.215 ENSMUST00000060188.7
Ppp1r2
protein phosphatase 1, regulatory (inhibitor) subunit 2
chr8_+_61487715 0.213 ENSMUST00000034058.6
ENSMUST00000126575.1
Cbr4

carbonyl reductase 4

chr5_-_31154152 0.209 ENSMUST00000114632.1
ENSMUST00000114631.2
ENSMUST00000067186.6
ENSMUST00000137165.1
ENSMUST00000131391.1
ENSMUST00000141823.1
ENSMUST00000154241.1
Mpv17






MpV17 mitochondrial inner membrane protein






chr13_+_100124850 0.207 ENSMUST00000022147.8
ENSMUST00000091321.5
ENSMUST00000143937.1
Smn1


survival motor neuron 1


chr16_-_18876655 0.207 ENSMUST00000023391.8
Mrpl40
mitochondrial ribosomal protein L40
chr17_+_57279094 0.203 ENSMUST00000169220.2
ENSMUST00000005889.9
ENSMUST00000112870.4
Vav1


vav 1 oncogene


chr1_+_139454747 0.195 ENSMUST00000053364.8
ENSMUST00000097554.3
Aspm

asp (abnormal spindle)-like, microcephaly associated (Drosophila)

chr11_-_99230998 0.195 ENSMUST00000103133.3
Smarce1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
chr2_+_117249725 0.186 ENSMUST00000028825.4
Fam98b
family with sequence similarity 98, member B
chr15_+_55557399 0.184 ENSMUST00000022998.7
Mtbp
Mdm2, transformed 3T3 cell double minute p53 binding protein
chr8_+_69822429 0.179 ENSMUST00000164890.1
ENSMUST00000034325.4
Lpar2

lysophosphatidic acid receptor 2

chr8_+_105373265 0.177 ENSMUST00000160650.1
Plekhg4
pleckstrin homology domain containing, family G (with RhoGef domain) member 4
chr4_-_116651644 0.177 ENSMUST00000030455.8
Akr1a1
aldo-keto reductase family 1, member A1 (aldehyde reductase)
chr3_-_9004686 0.173 ENSMUST00000120143.1
Tpd52
tumor protein D52
chr2_+_131491764 0.173 ENSMUST00000028806.5
ENSMUST00000110179.2
ENSMUST00000110189.2
ENSMUST00000110182.2
ENSMUST00000110183.2
ENSMUST00000110186.2
ENSMUST00000110188.1
Smox






spermine oxidase






chr9_-_50528641 0.171 ENSMUST00000034570.5
Pts
6-pyruvoyl-tetrahydropterin synthase
chr1_+_97770158 0.170 ENSMUST00000112844.3
ENSMUST00000112842.1
ENSMUST00000027571.6
Gin1


gypsy retrotransposon integrase 1


chrX_-_7947848 0.169 ENSMUST00000115642.1
ENSMUST00000033501.8
ENSMUST00000145675.1
Hdac6


histone deacetylase 6


chr9_+_104002546 0.166 ENSMUST00000035167.8
ENSMUST00000117054.1
Nphp3

nephronophthisis 3 (adolescent)

chr10_+_80603253 0.163 ENSMUST00000180350.1
Scamp4
secretory carrier membrane protein 4
chr4_+_11758147 0.154 ENSMUST00000029871.5
ENSMUST00000108303.1
Cdh17

cadherin 17

chr7_-_141168671 0.154 ENSMUST00000106033.3
Rnh1
ribonuclease/angiogenin inhibitor 1
chr11_+_60353324 0.153 ENSMUST00000070805.6
ENSMUST00000094140.2
ENSMUST00000108723.2
ENSMUST00000108722.4
Lrrc48



leucine rich repeat containing 48



chr5_-_100373484 0.153 ENSMUST00000182433.1
Sec31a
Sec31 homolog A (S. cerevisiae)
chr7_+_81762925 0.150 ENSMUST00000042166.4
Fam103a1
family with sequence similarity 103, member A1
chr4_+_134864536 0.129 ENSMUST00000030627.7
Rhd
Rh blood group, D antigen
chr3_+_85574109 0.120 ENSMUST00000127348.1
ENSMUST00000107672.1
ENSMUST00000107674.1
Pet112


PET112 homolog (S. cerevisiae)


chr4_+_36952930 0.116 ENSMUST00000144029.1
Gm12371
predicted gene 12371
chr12_-_113422730 0.111 ENSMUST00000177715.1
ENSMUST00000103426.1
Ighm

immunoglobulin heavy constant mu

chr6_-_8259098 0.103 ENSMUST00000012627.4
Rpa3
replication protein A3
chr15_-_76206309 0.095 ENSMUST00000073418.6
ENSMUST00000171634.1
ENSMUST00000076442.5
Plec


plectin


chr2_+_70661556 0.091 ENSMUST00000112201.1
ENSMUST00000028509.4
ENSMUST00000133432.1
ENSMUST00000112205.1
Gorasp2



golgi reassembly stacking protein 2



chr14_-_77036081 0.090 ENSMUST00000142300.1
Lacc1
laccase (multicopper oxidoreductase) domain containing 1
chr19_-_23075853 0.089 ENSMUST00000181623.1
C330002G04Rik
RIKEN cDNA C330002G04 gene
chr15_+_38661904 0.086 ENSMUST00000022904.6
Atp6v1c1
ATPase, H+ transporting, lysosomal V1 subunit C1
chr2_-_13271419 0.085 ENSMUST00000028059.2
Rsu1
Ras suppressor protein 1
chr5_+_122210134 0.085 ENSMUST00000100747.2
Hvcn1
hydrogen voltage-gated channel 1
chr11_-_100650693 0.080 ENSMUST00000103119.3
Zfp385c
zinc finger protein 385C
chr3_-_95133989 0.080 ENSMUST00000172572.2
ENSMUST00000173462.2
Scnm1

sodium channel modifier 1

chr5_+_90903864 0.079 ENSMUST00000075433.6
Cxcl2
chemokine (C-X-C motif) ligand 2
chr6_-_115675871 0.074 ENSMUST00000112949.1
Raf1
v-raf-leukemia viral oncogene 1
chr18_+_74216118 0.073 ENSMUST00000025444.6
Cxxc1
CXXC finger 1 (PHD domain)
chr7_-_104315455 0.067 ENSMUST00000106837.1
ENSMUST00000106839.2
ENSMUST00000070943.6
Trim12a


tripartite motif-containing 12A


chr19_+_25672408 0.066 ENSMUST00000053068.5
Dmrt2
doublesex and mab-3 related transcription factor 2
chr1_-_165634451 0.063 ENSMUST00000111435.2
ENSMUST00000068705.7
Mpzl1

myelin protein zero-like 1

chr17_+_55959146 0.062 ENSMUST00000086869.4
Ccdc94
coiled-coil domain containing 94
chr11_-_60417022 0.058 ENSMUST00000108721.1
Atpaf2
ATP synthase mitochondrial F1 complex assembly factor 2
chr3_+_124321031 0.052 ENSMUST00000058994.4
Tram1l1
translocation associated membrane protein 1-like 1
chr11_+_58104138 0.039 ENSMUST00000020822.5
Cnot8
CCR4-NOT transcription complex, subunit 8
chr2_+_127336152 0.028 ENSMUST00000028846.6
Dusp2
dual specificity phosphatase 2
chr2_-_13271268 0.016 ENSMUST00000137670.1
ENSMUST00000114791.2
Rsu1

Ras suppressor protein 1

chr6_+_115675983 0.015 ENSMUST00000068960.9
D830050J10Rik
RIKEN cDNA D830050J10 gene
chr7_-_30232186 0.015 ENSMUST00000006254.5
Tbcb
tubulin folding cofactor B
chr17_-_23771543 0.015 ENSMUST00000086325.5
Flywch1
FLYWCH-type zinc finger 1
chr3_-_106547726 0.014 ENSMUST00000039153.7
ENSMUST00000148269.1
ENSMUST00000068301.4
Cept1


choline/ethanolaminephosphotransferase 1


chr11_+_58104229 0.013 ENSMUST00000108843.1
ENSMUST00000134896.1
Cnot8

CCR4-NOT transcription complex, subunit 8

chr11_-_105937798 0.008 ENSMUST00000183493.1
Cyb561
cytochrome b-561
chr1_-_118982551 0.005 ENSMUST00000159678.1
Gli2
GLI-Kruppel family member GLI2
chr12_-_87443800 0.004 ENSMUST00000162961.1
Alkbh1
alkB, alkylation repair homolog 1 (E. coli)
chr13_-_90089060 0.002 ENSMUST00000161396.1
Xrcc4
X-ray repair complementing defective repair in Chinese hamster cells 4
chr5_-_129879038 0.001 ENSMUST00000026617.6
Phkg1
phosphorylase kinase gamma 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0033088 negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.5 2.5 GO:0007386 compartment pattern specification(GO:0007386)
0.5 1.9 GO:0006776 vitamin A metabolic process(GO:0006776)
0.3 0.9 GO:0001193 maintenance of transcriptional fidelity during DNA-templated transcription elongation(GO:0001192) maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter(GO:0001193)
0.3 1.8 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.2 2.4 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.2 0.8 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.2 0.5 GO:1904975 response to bleomycin(GO:1904975) cellular response to bleomycin(GO:1904976)
0.2 0.9 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.2 0.9 GO:0019659 fermentation(GO:0006113) lactate biosynthetic process from pyruvate(GO:0019244) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
0.2 0.5 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
0.1 0.4 GO:1903644 regulation of chaperone-mediated protein folding(GO:1903644)
0.1 0.4 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.1 0.5 GO:0014005 microglia differentiation(GO:0014004) microglia development(GO:0014005)
0.1 0.3 GO:0046032 ADP catabolic process(GO:0046032)
0.1 0.5 GO:0019614 catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
0.1 0.9 GO:0070236 positive regulation of immunoglobulin secretion(GO:0051024) negative regulation of activation-induced cell death of T cells(GO:0070236)
0.1 0.6 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.1 1.4 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.1 0.6 GO:0071474 cellular hyperosmotic response(GO:0071474)
0.1 0.3 GO:0002188 translation reinitiation(GO:0002188)
0.1 0.3 GO:0075525 viral translational termination-reinitiation(GO:0075525)
0.1 0.3 GO:0048539 bone marrow development(GO:0048539)
0.1 0.2 GO:0048496 maintenance of organ identity(GO:0048496)
0.1 0.2 GO:0030647 polyketide metabolic process(GO:0030638) aminoglycoside antibiotic metabolic process(GO:0030647) daunorubicin metabolic process(GO:0044597) doxorubicin metabolic process(GO:0044598)
0.1 0.5 GO:1903862 positive regulation of oxidative phosphorylation(GO:1903862)
0.1 0.2 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.1 0.4 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.0 0.3 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.3 GO:0007320 insemination(GO:0007320)
0.0 0.2 GO:0051661 maintenance of centrosome location(GO:0051661)
0.0 1.0 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.2 GO:0042364 L-ascorbic acid metabolic process(GO:0019852) water-soluble vitamin biosynthetic process(GO:0042364)
0.0 0.4 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 0.2 GO:0046208 spermine catabolic process(GO:0046208)
0.0 0.5 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.0 0.3 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.4 GO:1901673 regulation of mitotic spindle assembly(GO:1901673)
0.0 0.5 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.0 0.1 GO:0002339 B cell selection(GO:0002339)
0.0 0.4 GO:0006337 nucleosome disassembly(GO:0006337)
0.0 0.1 GO:0071550 death-inducing signaling complex assembly(GO:0071550)
0.0 0.1 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.2 GO:0032836 glomerular basement membrane development(GO:0032836)
0.0 0.7 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 0.2 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 0.2 GO:0006729 tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
0.0 0.2 GO:0015074 DNA integration(GO:0015074)
0.0 0.3 GO:0015701 bicarbonate transport(GO:0015701)
0.0 1.5 GO:0007338 single fertilization(GO:0007338)
0.0 0.3 GO:0043923 positive regulation by host of viral transcription(GO:0043923)
0.0 0.1 GO:0061055 myotome development(GO:0061055)
0.0 0.3 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.1 GO:0043461 proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.0 0.2 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 0.2 GO:0045954 positive regulation of natural killer cell mediated immunity(GO:0002717) positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)
0.0 0.3 GO:0033194 response to hydroperoxide(GO:0033194)
0.0 0.5 GO:0006406 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.0 0.1 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.0 0.1 GO:0071294 cellular response to zinc ion(GO:0071294)
0.0 0.1 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 GO:0043219 lateral loop(GO:0043219)
0.1 0.9 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 0.5 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.1 0.2 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.1 0.9 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 0.6 GO:0005688 U6 snRNP(GO:0005688)
0.1 0.2 GO:0097543 ciliary inversin compartment(GO:0097543)
0.1 0.2 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.0 0.9 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.5 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.4 GO:0000815 ESCRT III complex(GO:0000815)
0.0 1.9 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.2 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.4 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.1 GO:0031533 mRNA cap methyltransferase complex(GO:0031533)
0.0 0.2 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.0 0.3 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0 0.3 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.1 GO:0019815 B cell receptor complex(GO:0019815)
0.0 0.7 GO:0001741 XY body(GO:0001741)
0.0 0.4 GO:0016514 SWI/SNF complex(GO:0016514)
0.0 0.4 GO:0042555 MCM complex(GO:0042555)
0.0 0.8 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.5 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 0.2 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 0.2 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 0.2 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 1.0 GO:0016459 myosin complex(GO:0016459)
0.0 0.6 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 0.3 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.1 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.6 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.5 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.2 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.4 GO:0001772 immunological synapse(GO:0001772)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.5 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.6 1.8 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.4 2.4 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.3 1.9 GO:0019841 retinol binding(GO:0019841)
0.2 0.9 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.2 0.8 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.2 0.5 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.1 0.4 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.1 0.5 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.1 0.6 GO:0030621 U4 snRNA binding(GO:0030621)
0.1 0.5 GO:0001851 complement component C3b binding(GO:0001851)
0.1 0.6 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.1 0.2 GO:0004127 cytidylate kinase activity(GO:0004127)
0.1 0.9 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 0.2 GO:0046592 polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)
0.1 0.2 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.0 0.3 GO:1990932 5.8S rRNA binding(GO:1990932)
0.0 0.3 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.0 1.0 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.1 GO:0004482 mRNA (guanine-N7-)-methyltransferase activity(GO:0004482)
0.0 0.2 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 0.8 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.6 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.4 GO:0005167 neurotrophin TRK receptor binding(GO:0005167)
0.0 0.7 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.1 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.0 0.2 GO:0048038 quinone binding(GO:0048038)
0.0 1.1 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.5 GO:0035198 miRNA binding(GO:0035198)
0.0 0.9 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.0 0.2 GO:0008428 ribonuclease inhibitor activity(GO:0008428)
0.0 0.5 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 1.1 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.3 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.1 GO:0045322 unmethylated CpG binding(GO:0045322)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 1.8 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.0 1.9 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.5 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.9 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.2 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.9 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.8 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.5 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 0.6 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.1 1.8 REACTOME_GRB2_EVENTS_IN_ERBB2_SIGNALING Genes involved in GRB2 events in ERBB2 signaling
0.1 2.4 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 0.9 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.9 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.0 0.2 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.5 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.8 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.4 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.6 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.9 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.7 REACTOME_TRANSPORT_OF_MATURE_MRNA_DERIVED_FROM_AN_INTRONLESS_TRANSCRIPT Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.0 1.0 REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL Genes involved in Cell surface interactions at the vascular wall
0.0 0.4 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.3 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 0.2 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.1 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand