Motif ID: Alx4

Z-value: 0.551


Transcription factors associated with Alx4:

Gene SymbolEntrez IDGene Name
Alx4 ENSMUSG00000040310.6 Alx4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Alx4mm10_v2_chr2_+_93642307_93642388-0.066.5e-01Click!


Activity profile for motif Alx4.

activity profile for motif Alx4


Sorted Z-values histogram for motif Alx4

Sorted Z-values for motif Alx4



Network of associatons between targets according to the STRING database.



First level regulatory network of Alx4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_97479470 2.793 ENSMUST00000105287.3
 Dcn
decorin
chr6_-_136875794 2.613 ENSMUST00000032342.1
 Mgp
matrix Gla protein
chr7_-_45103747 2.277 ENSMUST00000003512.7
 Fcgrt
Fc receptor, IgG, alpha chain transporter
chr4_-_14621805 1.982 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chrX_+_73483602 1.612 ENSMUST00000033741.8
ENSMUST00000169489.1
 Bgn

biglycan

chr5_-_43981757 1.517 ENSMUST00000061299.7
 Fgfbp1
fibroblast growth factor binding protein 1
chr2_+_125136692 1.483 ENSMUST00000099452.2
 Ctxn2
cortexin 2
chrM_+_2743 1.481 ENSMUST00000082392.1
 mt-Nd1
mitochondrially encoded NADH dehydrogenase 1
chr15_+_9436028 1.423 ENSMUST00000042360.3
 Capsl
calcyphosine-like
chrM_+_9452 1.406 ENSMUST00000082411.1
 mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chrX_-_134111852 1.376 ENSMUST00000033610.6
 Nox1
NADPH oxidase 1
chr19_-_11604828 1.359 ENSMUST00000025582.4
 Ms4a6d
membrane-spanning 4-domains, subfamily A, member 6D
chr13_-_81710937 1.264 ENSMUST00000161920.1
ENSMUST00000048993.5
 Polr3g

polymerase (RNA) III (DNA directed) polypeptide G

chr9_-_123678782 1.251 ENSMUST00000170591.1
ENSMUST00000171647.1
 Slc6a20a

solute carrier family 6 (neurotransmitter transporter), member 20A

chr9_-_123678873 1.228 ENSMUST00000040960.6
 Slc6a20a
solute carrier family 6 (neurotransmitter transporter), member 20A
chr7_-_126676428 1.142 ENSMUST00000106373.1
 Sult1a1
sulfotransferase family 1A, phenol-preferring, member 1
chr7_-_126676357 1.137 ENSMUST00000106371.1
ENSMUST00000106372.3
ENSMUST00000155419.1
 Sult1a1


sulfotransferase family 1A, phenol-preferring, member 1


chr1_-_163725123 1.131 ENSMUST00000159679.1
 Mettl11b
methyltransferase like 11B
chr13_+_76579670 1.060 ENSMUST00000126960.1
ENSMUST00000109583.2
 Mctp1

multiple C2 domains, transmembrane 1

chr7_-_46667375 1.054 ENSMUST00000107669.2
 Tph1
tryptophan hydroxylase 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 93 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 4.4 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 2.6 GO:0030500 regulation of bone mineralization(GO:0030500)
0.2 2.5 GO:0015838 proline transport(GO:0015824) amino-acid betaine transport(GO:0015838)
0.3 2.3 GO:0019532 oxalate transport(GO:0019532)
0.2 2.3 GO:0051923 sulfation(GO:0051923)
0.6 2.2 GO:0072592 oxygen metabolic process(GO:0072592)
0.1 1.9 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0 1.9 GO:0022904 respiratory electron transport chain(GO:0022904)
0.4 1.7 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.2 1.6 GO:1901162 serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.2 1.5 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.1 1.4 GO:0033194 response to hydroperoxide(GO:0033194)
0.0 1.3 GO:0071385 cellular response to glucocorticoid stimulus(GO:0071385)
0.0 1.3 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.1 1.2 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.4 1.1 GO:0002940 tRNA N2-guanine methylation(GO:0002940)
0.1 1.0 GO:0021886 hypothalamus gonadotrophin-releasing hormone neuron differentiation(GO:0021886) hypothalamus gonadotrophin-releasing hormone neuron development(GO:0021888)
0.1 1.0 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.1 1.0 GO:0045607 regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.1 1.0 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.7 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 3.2 GO:0005802 trans-Golgi network(GO:0005802)
0.1 3.0 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 2.8 GO:0098644 complex of collagen trimers(GO:0098644)
0.0 2.4 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 2.2 GO:0070469 respiratory chain(GO:0070469)
0.0 1.9 GO:0031012 extracellular matrix(GO:0031012)
0.0 1.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.3 1.4 GO:0071438 invadopodium membrane(GO:0071438)
0.0 1.1 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 1.0 GO:0016272 prefoldin complex(GO:0016272)
0.3 0.8 GO:0042585 germinal vesicle(GO:0042585)
0.1 0.8 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.8 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.8 GO:0072562 blood microparticle(GO:0072562)
0.1 0.7 GO:0034709 methylosome(GO:0034709)
0.0 0.6 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.6 GO:0042555 MCM complex(GO:0042555)
0.0 0.6 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 0.5 GO:0070820 tertiary granule(GO:0070820)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 72 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.3 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 3.9 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 2.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.3 2.5 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.8 2.3 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.5 2.3 GO:0019770 IgG receptor activity(GO:0019770)
0.2 2.3 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.3 1.9 GO:0000213 tRNA-intron endonuclease activity(GO:0000213) endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.2 1.7 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.5 1.6 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.1 1.6 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 1.5 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.5 1.4 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.2 1.3 GO:1990932 5.8S rRNA binding(GO:1990932)
0.2 1.2 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.2 1.1 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.0 1.1 GO:0008276 protein methyltransferase activity(GO:0008276)
0.0 1.0 GO:0043014 alpha-tubulin binding(GO:0043014)
0.2 0.9 GO:0030151 molybdenum ion binding(GO:0030151)
0.2 0.9 GO:0004301 epoxide hydrolase activity(GO:0004301)

Gene overrepresentation in C2:CP category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.4 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 3.6 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 1.9 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 1.6 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.4 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 0.8 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.8 PID_ATR_PATHWAY ATR signaling pathway
0.0 0.8 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 0.6 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 0.5 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 0.5 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 0.5 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY PI3K Pathway
0.0 0.4 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.0 0.4 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.4 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 2.5 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.0 2.4 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.3 2.3 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 1.6 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 1.0 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 1.0 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 1.0 REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.0 0.9 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 0.8 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 0.8 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.6 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.1 0.5 REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.5 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.5 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.5 REACTOME_POST_TRANSLATIONAL_MODIFICATION_SYNTHESIS_OF_GPI_ANCHORED_PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.0 0.5 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.0 0.4 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.4 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.4 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling