Motif ID: Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec

Z-value: 0.635

Transcription factors associated with Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec:

Gene SymbolEntrez IDGene Name
Arntl ENSMUSG00000055116.7 Arntl
Mitf ENSMUSG00000035158.9 Mitf
Mlx ENSMUSG00000017801.9 Mlx
Mlxipl ENSMUSG00000005373.7 Mlxipl
Tfe3 ENSMUSG00000000134.11 Tfe3
Tfec ENSMUSG00000029553.7 Tfec

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Arntlmm10_v2_chr7_+_113207465_113207595-0.421.3e-03Click!
Mlxmm10_v2_chr11_+_101087277_101087323-0.293.5e-02Click!
Mlxiplmm10_v2_chr5_+_135106881_1351069180.124.0e-01Click!
Mitfmm10_v2_chr6_+_97807014_97807067-0.095.2e-01Click!
Tfe3mm10_v2_chrX_+_7763943_77640870.066.4e-01Click!


Activity profile for motif Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec.

activity profile for motif Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec


Sorted Z-values histogram for motif Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec

Sorted Z-values for motif Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec



Network of associatons between targets according to the STRING database.



First level regulatory network of Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_127063599 7.172 ENSMUST00000120226.1
ENSMUST00000133115.1
 Cdk4

cyclin-dependent kinase 4

chr11_+_70000578 6.647 ENSMUST00000019362.8
 Dvl2
dishevelled 2, dsh homolog (Drosophila)
chr10_+_127063527 6.243 ENSMUST00000006911.5
 Cdk4
cyclin-dependent kinase 4
chr19_-_4201591 6.193 ENSMUST00000025740.6
 Rad9a
RAD9 homolog A
chr3_+_137864573 5.295 ENSMUST00000174561.1
ENSMUST00000173790.1
 H2afz

H2A histone family, member Z

chr6_+_128362919 5.017 ENSMUST00000073316.6
 Foxm1
forkhead box M1
chr3_+_159495408 4.751 ENSMUST00000120272.1
ENSMUST00000029825.7
ENSMUST00000106041.2
 Depdc1a


DEP domain containing 1a


chr6_+_108660616 4.727 ENSMUST00000032194.4
 Bhlhe40
basic helix-loop-helix family, member e40
chr13_+_108316332 4.653 ENSMUST00000051594.5
 Depdc1b
DEP domain containing 1B
chr11_-_94653964 4.626 ENSMUST00000039949.4
 Eme1
essential meiotic endonuclease 1 homolog 1 (S. pombe)
chr10_+_41519493 4.544 ENSMUST00000019962.8
 Cd164
CD164 antigen
chr5_-_137314175 4.454 ENSMUST00000024119.9
 Trip6
thyroid hormone receptor interactor 6
chr13_+_108316395 4.299 ENSMUST00000171178.1
 Depdc1b
DEP domain containing 1B
chr3_+_137864487 4.243 ENSMUST00000041045.7
 H2afz
H2A histone family, member Z
chr2_-_71546745 4.152 ENSMUST00000024159.6
 Dlx2
distal-less homeobox 2
chr19_-_10203880 3.907 ENSMUST00000142241.1
ENSMUST00000116542.2
ENSMUST00000025651.5
ENSMUST00000156291.1
 Fen1



flap structure specific endonuclease 1



chr2_+_121449362 3.844 ENSMUST00000110615.1
ENSMUST00000099475.5
 Serf2

small EDRK-rich factor 2

chr9_-_22389113 3.840 ENSMUST00000040912.7
 Anln
anillin, actin binding protein
chr14_-_118052235 3.695 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr17_+_56040350 3.630 ENSMUST00000002914.8
 Chaf1a
chromatin assembly factor 1, subunit A (p150)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 570 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.4 13.4 GO:0010288 response to lead ion(GO:0010288)
0.4 9.8 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.7 7.9 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.3 7.9 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
1.3 6.6 GO:0014022 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.9 6.6 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.1 6.5 GO:0030177 positive regulation of Wnt signaling pathway(GO:0030177)
1.2 6.2 GO:0090521 glomerular visceral epithelial cell migration(GO:0090521)
0.2 6.2 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.3 5.9 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.9 5.5 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.7 5.3 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.7 5.0 GO:2000781 positive regulation of double-strand break repair(GO:2000781)
0.8 4.8 GO:1904715 negative regulation of chaperone-mediated autophagy(GO:1904715)
0.9 4.7 GO:0072429 response to intra-S DNA damage checkpoint signaling(GO:0072429)
0.3 4.5 GO:0002192 IRES-dependent translational initiation(GO:0002192)
0.2 4.4 GO:0060009 Sertoli cell development(GO:0060009)
1.4 4.2 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.3 4.0 GO:0038166 angiotensin-activated signaling pathway(GO:0038166)
0.5 3.7 GO:0021847 ventricular zone neuroblast division(GO:0021847)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 222 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 16.6 GO:0016604 nuclear body(GO:0016604)
3.4 13.4 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.1 10.6 GO:0022626 cytosolic ribosome(GO:0022626)
1.3 9.4 GO:0001740 Barr body(GO:0001740)
0.1 7.5 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 6.4 GO:0016235 aggresome(GO:0016235)
1.0 6.2 GO:0030896 checkpoint clamp complex(GO:0030896)
0.0 6.1 GO:0030529 intracellular ribonucleoprotein complex(GO:0030529)
0.1 5.5 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.3 5.3 GO:0031083 BLOC-1 complex(GO:0031083)
0.1 5.3 GO:0072686 mitotic spindle(GO:0072686)
1.7 5.1 GO:0033186 CAF-1 complex(GO:0033186)
0.1 4.9 GO:0031519 PcG protein complex(GO:0031519)
0.9 4.7 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.8 3.8 GO:0005826 actomyosin contractile ring(GO:0005826)
0.2 3.8 GO:0030914 STAGA complex(GO:0030914)
0.2 3.6 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.3 3.5 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 3.5 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 3.5 GO:0031970 organelle envelope lumen(GO:0031970)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 341 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 14.7 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.3 12.1 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 9.5 GO:0003735 structural constituent of ribosome(GO:0003735)
1.4 8.4 GO:0043426 MRF binding(GO:0043426)
0.0 8.3 GO:0005096 GTPase activator activity(GO:0005096)
0.0 7.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 6.7 GO:0005109 frizzled binding(GO:0005109)
1.6 6.2 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.1 6.2 GO:0003727 single-stranded RNA binding(GO:0003727)
0.1 6.1 GO:0016831 carboxy-lyase activity(GO:0016831)
0.8 5.3 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.5 5.2 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.8 4.7 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.1 4.7 GO:0050699 WW domain binding(GO:0050699)
0.3 4.5 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.2 4.0 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.8 3.9 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.6 3.7 GO:1990189 peptide-serine-N-acetyltransferase activity(GO:1990189)
0.3 3.7 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.5 3.6 GO:0031419 cobalamin binding(GO:0031419)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 15.0 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 10.4 PID_CMYB_PATHWAY C-MYB transcription factor network
0.2 8.1 PID_ATR_PATHWAY ATR signaling pathway
0.3 7.7 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.2 7.1 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 6.3 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.3 5.9 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.1 5.9 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.2 5.5 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 5.4 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 5.4 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 4.6 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.1 3.7 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.1 3.6 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.1 3.6 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 3.5 PID_PLK1_PATHWAY PLK1 signaling events
0.1 3.4 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 2.3 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.1 2.3 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.2 2.2 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 106 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 17.7 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.4 17.1 REACTOME_G1_PHASE Genes involved in G1 Phase
0.2 10.7 REACTOME_G2_M_CHECKPOINTS Genes involved in G2/M Checkpoints
0.3 10.4 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.2 8.2 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.3 7.8 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 7.7 REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION Genes involved in Class I MHC mediated antigen processing & presentation
0.3 6.9 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 6.9 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 6.8 REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.1 6.7 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.1 6.5 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.5 4.7 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.2 4.4 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.1 4.4 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 4.1 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 4.1 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.1 3.9 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.3 3.7 REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE Genes involved in Cell death signalling via NRAGE, NRIF and NADE
0.1 3.7 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription