Motif ID: Ascl2

Z-value: 0.569


Transcription factors associated with Ascl2:

Gene SymbolEntrez IDGene Name
Ascl2 ENSMUSG00000009248.5 Ascl2



Activity profile for motif Ascl2.

activity profile for motif Ascl2


Sorted Z-values histogram for motif Ascl2

Sorted Z-values for motif Ascl2



Network of associatons between targets according to the STRING database.



First level regulatory network of Ascl2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_106458440 3.763 ENSMUST00000086795.6
 Barhl2
BarH-like 2 (Drosophila)
chr7_-_28302238 3.669 ENSMUST00000108315.3
 Dll3
delta-like 3 (Drosophila)
chr15_-_78773452 3.132 ENSMUST00000018313.5
 Mfng
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr8_+_31091593 2.590 ENSMUST00000161713.1
 Dusp26
dual specificity phosphatase 26 (putative)
chr11_+_99864476 2.239 ENSMUST00000092694.3
 Gm11559
predicted gene 11559
chr7_+_45216671 2.143 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr6_+_56017489 2.098 ENSMUST00000052827.4
 Ppp1r17
protein phosphatase 1, regulatory subunit 17
chr7_-_141443314 2.000 ENSMUST00000106005.2
 Lrdd
leucine-rich and death domain containing
chr8_+_105518736 1.917 ENSMUST00000034363.5
 Hsd11b2
hydroxysteroid 11-beta dehydrogenase 2
chr5_+_149411749 1.833 ENSMUST00000093110.5
 Medag
mesenteric estrogen dependent adipogenesis
chr7_+_142471838 1.693 ENSMUST00000038946.2
 Lsp1
lymphocyte specific 1
chr6_-_56362356 1.671 ENSMUST00000044505.7
ENSMUST00000166102.1
ENSMUST00000164037.1
ENSMUST00000114327.2
 Pde1c



phosphodiesterase 1C



chr6_+_105677745 1.630 ENSMUST00000113261.2
ENSMUST00000113264.2
 Cntn4

contactin 4

chr2_+_136052180 1.493 ENSMUST00000144403.1
 Lamp5
lysosomal-associated membrane protein family, member 5
chr5_+_114568016 1.457 ENSMUST00000043650.7
 Fam222a
family with sequence similarity 222, member A
chr6_-_72235559 1.456 ENSMUST00000042646.7
 Atoh8
atonal homolog 8 (Drosophila)
chr8_-_122699066 1.453 ENSMUST00000127984.1
 Cbfa2t3
core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)
chr8_-_105471481 1.440 ENSMUST00000014990.6
 Tppp3
tubulin polymerization-promoting protein family member 3
chr7_+_142472080 1.438 ENSMUST00000105966.1
 Lsp1
lymphocyte specific 1
chr4_+_11156411 1.402 ENSMUST00000029865.3
 Trp53inp1
transformation related protein 53 inducible nuclear protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 154 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.8 GO:0001709 cell fate determination(GO:0001709)
0.7 3.7 GO:0007386 compartment pattern specification(GO:0007386)
0.3 3.1 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.9 2.6 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.1 2.4 GO:0048368 lateral mesoderm development(GO:0048368)
0.3 2.3 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.1 2.1 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.2 1.9 GO:0001977 renal system process involved in regulation of blood volume(GO:0001977)
0.0 1.8 GO:0050873 brown fat cell differentiation(GO:0050873)
0.0 1.8 GO:0010921 regulation of phosphatase activity(GO:0010921)
0.1 1.7 GO:0046069 cGMP catabolic process(GO:0046069)
0.1 1.6 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.2 1.5 GO:1903715 regulation of aerobic respiration(GO:1903715)
0.1 1.5 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.0 1.5 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.5 1.4 GO:1904760 myofibroblast differentiation(GO:0036446) regulation of myofibroblast differentiation(GO:1904760)
0.1 1.4 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.0 1.4 GO:0001578 microtubule bundle formation(GO:0001578)
0.4 1.3 GO:0072076 hyaluranon cable assembly(GO:0036118) nephrogenic mesenchyme development(GO:0072076) negative regulation of glomerular mesangial cell proliferation(GO:0072125) negative regulation of glomerulus development(GO:0090194) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.1 1.3 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.1 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.2 2.8 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.5 2.3 GO:0032133 interphase microtubule organizing center(GO:0031021) chromosome passenger complex(GO:0032133)
0.7 2.1 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.0 2.1 GO:0031225 anchored component of membrane(GO:0031225)
0.1 1.6 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.2 1.5 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.2 1.4 GO:0097427 microtubule bundle(GO:0097427)
0.0 1.4 GO:0005776 autophagosome(GO:0005776)
0.0 1.3 GO:0000791 euchromatin(GO:0000791)
0.3 1.0 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.1 1.0 GO:0001520 outer dense fiber(GO:0001520)
0.1 0.8 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.8 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.7 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.7 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.6 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 0.5 GO:0071817 MMXD complex(GO:0071817)
0.1 0.5 GO:0000923 equatorial microtubule organizing center(GO:0000923)
0.1 0.5 GO:0097452 GAIT complex(GO:0097452)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 102 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.3 GO:0003779 actin binding(GO:0003779)
0.0 6.6 GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982)
0.1 4.3 GO:0005112 Notch binding(GO:0005112)
0.1 3.7 GO:0008536 Ran GTPase binding(GO:0008536)
1.0 3.1 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.9 2.6 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.2 2.6 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0033764)
0.1 2.3 GO:0008307 structural constituent of muscle(GO:0008307)
0.3 2.1 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.1 2.1 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.2 1.8 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.2 1.8 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.2 1.7 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 1.7 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 1.5 GO:0070700 BMP receptor binding(GO:0070700)
0.0 1.5 GO:0070888 E-box binding(GO:0070888)
0.0 1.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 1.4 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.3 1.3 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.0 1.3 GO:0016209 antioxidant activity(GO:0016209)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.3 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 4.2 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 2.3 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 2.0 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 1.9 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.6 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 1.3 PID_ALK2_PATHWAY ALK2 signaling events
0.0 1.1 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 1.0 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 1.0 PID_ERBB1_DOWNSTREAM_PATHWAY ErbB1 downstream signaling
0.0 0.8 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.6 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 0.5 PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY EGF receptor (ErbB1) signaling pathway
0.0 0.5 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.5 ST_GA13_PATHWAY G alpha 13 Pathway
0.0 0.4 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 0.4 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.4 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.4 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.4 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.8 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 2.5 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 2.0 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 1.7 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 1.6 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 1.6 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 1.4 REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.0 1.4 REACTOME_PHASE_II_CONJUGATION Genes involved in Phase II conjugation
0.0 1.1 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 1.1 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 1.0 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 0.8 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 0.7 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.0 0.7 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules
0.1 0.6 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 0.6 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.6 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.6 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.6 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.5 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling