Motif ID: Atf1_Creb5

Z-value: 0.653

Transcription factors associated with Atf1_Creb5:

Gene SymbolEntrez IDGene Name
Atf1 ENSMUSG00000023027.6 Atf1
Creb5 ENSMUSG00000053007.6 Creb5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Atf1mm10_v2_chr15_+_100227871_100227878-0.172.3e-01Click!
Creb5mm10_v2_chr6_+_53573364_53573394-0.162.4e-01Click!


Activity profile for motif Atf1_Creb5.

activity profile for motif Atf1_Creb5


Sorted Z-values histogram for motif Atf1_Creb5

Sorted Z-values for motif Atf1_Creb5



Network of associatons between targets according to the STRING database.



First level regulatory network of Atf1_Creb5

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_102490418 2.922 ENSMUST00000020040.3
 Nts
neurotensin
chr9_-_96752822 2.586 ENSMUST00000152594.1
 Zbtb38
zinc finger and BTB domain containing 38
chrX_-_21061981 2.580 ENSMUST00000040628.5
ENSMUST00000115333.2
ENSMUST00000115334.1
 Zfp182


zinc finger protein 182


chr11_+_101468164 2.155 ENSMUST00000001347.6
 Rnd2
Rho family GTPase 2
chr7_+_44496588 1.998 ENSMUST00000107927.3
 Fam71e1
family with sequence similarity 71, member E1
chr12_+_102554966 1.961 ENSMUST00000021610.5
 Chga
chromogranin A
chr7_+_130865756 1.900 ENSMUST00000120441.1
 Plekha1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr7_+_130865835 1.871 ENSMUST00000075181.4
ENSMUST00000048180.5
 Plekha1

pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1

chr14_-_59597836 1.810 ENSMUST00000167100.1
ENSMUST00000022555.4
ENSMUST00000056997.7
ENSMUST00000171683.1
 Cdadc1



cytidine and dCMP deaminase domain containing 1



chr4_-_107810948 1.797 ENSMUST00000097930.1
 B230314M03Rik
RIKEN cDNA B230314M03 gene
chr3_+_145118564 1.777 ENSMUST00000098538.2
ENSMUST00000106192.2
ENSMUST00000029920.8
ENSMUST00000098539.2
 Odf2l



outer dense fiber of sperm tails 2-like



chr2_+_132781278 1.719 ENSMUST00000028826.3
 Chgb
chromogranin B
chrX_-_111697069 1.644 ENSMUST00000113422.2
ENSMUST00000038472.5
 Hdx

highly divergent homeobox

chr11_-_79254663 1.595 ENSMUST00000017821.5
 Wsb1
WD repeat and SOCS box-containing 1
chr19_-_61228396 1.575 ENSMUST00000076046.6
 Csf2ra
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
chr6_-_39725448 1.563 ENSMUST00000002487.8
 Braf
Braf transforming gene
chr7_-_138846202 1.520 ENSMUST00000118810.1
ENSMUST00000075667.4
ENSMUST00000119664.1
 Mapk1ip1


mitogen-activated protein kinase 1 interacting protein 1


chr17_-_56476462 1.502 ENSMUST00000067538.5
 Ptprs
protein tyrosine phosphatase, receptor type, S
chr9_+_53850243 1.454 ENSMUST00000048485.5
 Sln
sarcolipin
chr10_+_29211637 1.426 ENSMUST00000092627.4
 9330159F19Rik
RIKEN cDNA 9330159F19 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 158 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.3 GO:0001553 luteinization(GO:0001553)
0.0 2.6 GO:0008542 visual learning(GO:0008542)
0.1 2.2 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 2.1 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.7 2.0 GO:1901079 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738) positive regulation of relaxation of muscle(GO:1901079)
0.1 1.6 GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus(GO:0097011)
0.4 1.5 GO:1901894 regulation of calcium-transporting ATPase activity(GO:1901894)
0.3 1.5 GO:0034162 toll-like receptor 9 signaling pathway(GO:0034162)
0.2 1.5 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.2 1.2 GO:0032196 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196)
0.1 1.2 GO:0044829 positive regulation by host of viral genome replication(GO:0044829)
0.1 1.2 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.1 1.2 GO:0035881 amacrine cell differentiation(GO:0035881)
0.4 1.1 GO:1903774 positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.2 1.1 GO:0032911 negative regulation of transforming growth factor beta1 production(GO:0032911)
0.1 1.1 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.1 1.1 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.2 1.0 GO:0051189 molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.1 1.0 GO:0030432 peristalsis(GO:0030432)
0.1 1.0 GO:0014883 transition between fast and slow fiber(GO:0014883)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.2 GO:0032587 ruffle membrane(GO:0032587)
0.4 2.0 GO:0042583 chromaffin granule(GO:0042583)
0.1 1.7 GO:1990023 mitotic spindle midzone(GO:1990023)
0.1 1.6 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 1.5 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 1.4 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 1.2 GO:0000242 pericentriolar material(GO:0000242)
0.0 1.2 GO:0008023 transcription elongation factor complex(GO:0008023)
0.2 1.1 GO:0033503 HULC complex(GO:0033503)
0.2 1.0 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.1 1.0 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 1.0 GO:0030660 Golgi-associated vesicle membrane(GO:0030660)
0.1 0.9 GO:0044754 autolysosome(GO:0044754)
0.0 0.9 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.9 GO:0072686 mitotic spindle(GO:0072686)
0.0 0.9 GO:0030141 secretory granule(GO:0030141)
0.0 0.9 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 0.8 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.1 0.8 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.8 GO:0032588 trans-Golgi network membrane(GO:0032588)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 94 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.2 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1 2.9 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 2.7 GO:0004896 cytokine receptor activity(GO:0004896)
0.1 2.6 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 1.8 GO:0047485 protein N-terminus binding(GO:0047485)
0.0 1.6 GO:0005125 cytokine activity(GO:0005125)
0.0 1.6 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.2 1.5 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.0 1.4 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.2 1.3 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.1 1.3 GO:0016783 sulfurtransferase activity(GO:0016783)
0.1 1.3 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.0 1.3 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 1.3 GO:0051213 dioxygenase activity(GO:0051213)
0.1 1.2 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.2 1.1 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.1 1.1 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.1 1.1 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 1.1 GO:0071889 14-3-3 protein binding(GO:0071889)
0.3 1.0 GO:0004994 somatostatin receptor activity(GO:0004994)

Gene overrepresentation in C2:CP category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.8 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.0 2.5 PID_AP1_PATHWAY AP-1 transcription factor network
0.1 1.6 PID_GMCSF_PATHWAY GMCSF-mediated signaling events
0.1 1.5 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.1 1.2 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 1.2 PID_VEGFR1_PATHWAY VEGFR1 specific signals
0.0 0.9 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.9 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.9 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.2 0.8 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.8 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.6 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 0.6 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.0 0.5 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 0.4 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 0.1 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.1 PID_FOXM1_PATHWAY FOXM1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.7 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 2.8 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 1.6 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.1 1.5 REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN Genes involved in Signalling to p38 via RIT and RIN
0.1 1.1 REACTOME_MEMBRANE_BINDING_AND_TARGETTING_OF_GAG_PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.1 1.1 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 1.1 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.0 1.0 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 1.0 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.0 0.9 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 0.8 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.1 0.8 REACTOME_ACYL_CHAIN_REMODELLING_OF_PC Genes involved in Acyl chain remodelling of PC
0.0 0.8 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.1 0.7 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism
0.1 0.6 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.6 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.6 REACTOME_KINESINS Genes involved in Kinesins
0.0 0.6 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.6 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.6 REACTOME_AMYLOIDS Genes involved in Amyloids