• All motifs sorted by activity significance
• All samples sorted alphabetically
• Mean activities
• All promoters sorted by FOV

• Activities table
• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)
• Download the whole report

Motif ID: Atf4

Z-value: 0.921

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr1_-_71653162	7.948	ENSMUST00000055226.6	Fn1	fibronectin 1
chrX_+_103422010	6.718	ENSMUST00000182089.1	Gm26992	predicted gene, 26992
chr19_-_12501996	5.888	ENSMUST00000045521.7	Dtx4	deltex 4 homolog (Drosophila)
chr2_+_119351222	5.489	ENSMUST00000028780.3	Chac1	ChaC, cation transport regulator 1
chr9_+_109931774	4.045	ENSMUST00000169851.2	Map4	microtubule-associated protein 4
chr5_-_148399901	3.843	ENSMUST00000048116.8	Slc7a1	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr4_+_43957678	3.800	ENSMUST00000107855.1	Glipr2	GLI pathogenesis-related 2
chr1_-_22315792	2.882	ENSMUST00000164877.1	Rims1	regulating synaptic membrane exocytosis 1
chr11_-_35798884	2.834	ENSMUST00000160726.2	Fbll1	fibrillarin-like 1
chrX_-_162565514	2.610	ENSMUST00000154424.1	Reps2	RALBP1 associated Eps domain containing protein 2
chr4_+_117835387	2.527	ENSMUST00000169885.1	Slc6a9	solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr11_-_120643643	2.393	ENSMUST00000141254.1 ENSMUST00000170556.1 ENSMUST00000151876.1 ENSMUST00000026133.8 ENSMUST00000139706.1	Pycr1	pyrroline-5-carboxylate reductase 1
chr11_-_20332689	2.181	ENSMUST00000109594.1	Slc1a4	solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr11_-_20332654	2.107	ENSMUST00000004634.6	Slc1a4	solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr6_-_23248264	1.994	ENSMUST00000031709.5	Fezf1	Fez family zinc finger 1
chr7_-_126566364	1.907	ENSMUST00000032992.5	Eif3c	eukaryotic translation initiation factor 3, subunit C
chr4_-_129189600	1.732	ENSMUST00000117497.1 ENSMUST00000117350.1	S100pbp	S100P binding protein
chr13_+_49682191	1.683	ENSMUST00000172254.1	Iars	isoleucine-tRNA synthetase
chr10_-_83533383	1.618	ENSMUST00000146640.1	Aldh1l2	aldehyde dehydrogenase 1 family, member L2
chr18_-_64516547	1.592	ENSMUST00000025483.9	Nars	asparaginyl-tRNA synthetase
chr4_+_129189760	1.559	ENSMUST00000106054.2 ENSMUST00000001365.2	Yars	tyrosyl-tRNA synthetase
chr3_-_127409014	1.549	ENSMUST00000182008.1 ENSMUST00000182711.1 ENSMUST00000182547.1	Ank2	ankyrin 2, brain
chr2_+_163995503	1.547	ENSMUST00000131288.1	Ywhab	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
chr1_-_191183244	1.517	ENSMUST00000027941.8	Atf3	activating transcription factor 3
chr6_+_55037988	1.466	ENSMUST00000003572.8	Gars	glycyl-tRNA synthetase
chr9_+_109931458	1.446	ENSMUST00000072772.5 ENSMUST00000035055.8	Map4	microtubule-associated protein 4
chr15_-_98953541	1.444	ENSMUST00000097014.5	Tuba1a	tubulin, alpha 1A
chr3_-_127408937	1.392	ENSMUST00000183095.1 ENSMUST00000182610.1	Ank2	ankyrin 2, brain
chr6_+_129533183	1.384	ENSMUST00000032264.6	Gabarapl1	gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1
chr7_-_143600049	1.378	ENSMUST00000105909.3 ENSMUST00000010899.7	Cars	cysteinyl-tRNA synthetase
chr8_+_117157972	1.361	ENSMUST00000064488.4 ENSMUST00000162997.1	Gan	giant axonal neuropathy
chr10_-_68278713	1.355	ENSMUST00000020106.7	Arid5b	AT rich interactive domain 5B (MRF1-like)
chr4_-_129189512	1.335	ENSMUST00000117965.1 ENSMUST00000106061.2 ENSMUST00000072431.6	S100pbp	S100P binding protein
chr3_-_127408986	1.300	ENSMUST00000182588.1 ENSMUST00000182959.1 ENSMUST00000182452.1	Ank2	ankyrin 2, brain
chr9_+_109931863	1.290	ENSMUST00000165876.1	Map4	microtubule-associated protein 4
chr3_-_127409044	1.243	ENSMUST00000182704.1	Ank2	ankyrin 2, brain
chr2_-_3512746	1.220	ENSMUST00000027961.5 ENSMUST00000056700.7	Hspa14 Hspa14	heat shock protein 14 heat shock protein 14
chr1_-_78488846	1.208	ENSMUST00000068333.7 ENSMUST00000170217.1	Farsb	phenylalanyl-tRNA synthetase, beta subunit
chr7_-_126625676	1.199	ENSMUST00000032961.3	Nupr1	nuclear protein transcription regulator 1
chr10_+_102158858	1.192	ENSMUST00000138522.1 ENSMUST00000163753.1 ENSMUST00000138016.1	Mgat4c	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr4_+_127021311	1.162	ENSMUST00000030623.7	Sfpq	splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)
chr8_+_75093591	1.158	ENSMUST00000005548.6	Hmox1	heme oxygenase (decycling) 1
chr3_+_89715016	1.111	ENSMUST00000098924.2	Adar	adenosine deaminase, RNA-specific
chr11_-_115276973	1.096	ENSMUST00000021078.2	Fdxr	ferredoxin reductase
chr5_-_90223923	1.068	ENSMUST00000118816.1 ENSMUST00000048363.7	Cox18	cytochrome c oxidase assembly protein 18
chr19_+_44203265	1.034	ENSMUST00000026220.5	Scd3	stearoyl-coenzyme A desaturase 3
chr7_+_138846579	1.025	ENSMUST00000155672.1	Ppp2r2d	protein phosphatase 2, regulatory subunit B, delta isoform
chr12_+_85599047	1.007	ENSMUST00000177587.1	Jdp2	Jun dimerization protein 2
chr4_-_129189646	0.991	ENSMUST00000106059.1	S100pbp	S100P binding protein
chr15_+_99393219	0.990	ENSMUST00000159209.1	Tmbim6	transmembrane BAX inhibitor motif containing 6
chr14_-_66868572	0.981	ENSMUST00000022629.8	Dpysl2	dihydropyrimidinase-like 2
chr11_+_100320596	0.945	ENSMUST00000152521.1	Eif1	eukaryotic translation initiation factor 1
chr7_+_126565919	0.913	ENSMUST00000180459.1	G730046D07Rik	RIKEN cDNA G730046D07 gene
chr17_+_34187545	0.886	ENSMUST00000170086.1	Tap1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr4_+_124741844	0.859	ENSMUST00000094782.3 ENSMUST00000153837.1 ENSMUST00000154229.1	Inpp5b	inositol polyphosphate-5-phosphatase B
chr13_-_53473074	0.848	ENSMUST00000021922.8	Msx2	msh homeobox 2
chr7_-_126502094	0.824	ENSMUST00000179818.1	Atxn2l	ataxin 2-like
chr13_-_30545254	0.800	ENSMUST00000042834.3	Uqcrfs1	ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
chr8_+_111033890	0.784	ENSMUST00000034441.7	Aars	alanyl-tRNA synthetase
chr13_-_101692624	0.771	ENSMUST00000035532.6	Pik3r1	phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chrX_+_94234594	0.762	ENSMUST00000153900.1	Klhl15	kelch-like 15
chr15_-_83510861	0.760	ENSMUST00000109479.1 ENSMUST00000109480.1 ENSMUST00000016897.4	Ttll1	tubulin tyrosine ligase-like 1
chr17_+_34187789	0.755	ENSMUST00000041633.8	Tap1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr11_-_87826023	0.739	ENSMUST00000103177.3	Lpo	lactoperoxidase
chr5_-_145140238	0.735	ENSMUST00000031627.8	Pdap1	PDGFA associated protein 1
chr15_-_83510793	0.721	ENSMUST00000154401.1	Ttll1	tubulin tyrosine ligase-like 1
chr10_+_121739915	0.719	ENSMUST00000065600.7 ENSMUST00000136432.1	BC048403	cDNA sequence BC048403
chr13_+_49682100	0.715	ENSMUST00000165316.1 ENSMUST00000047363.7	Iars	isoleucine-tRNA synthetase
chr10_-_127311740	0.687	ENSMUST00000037290.5 ENSMUST00000171564.1	Mars	methionine-tRNA synthetase
chr12_-_108893197	0.670	ENSMUST00000161154.1 ENSMUST00000161410.1	Wars	tryptophanyl-tRNA synthetase
chr16_-_34095983	0.670	ENSMUST00000114973.1 ENSMUST00000114964.1	Kalrn	kalirin, RhoGEF kinase
chr4_+_41942037	0.596	ENSMUST00000181518.1	Gm20878	predicted gene, 20878
chr11_-_75422586	0.578	ENSMUST00000138661.1 ENSMUST00000000769.7	Serpinf1	serine (or cysteine) peptidase inhibitor, clade F, member 1
chr12_+_85599388	0.560	ENSMUST00000050687.6	Jdp2	Jun dimerization protein 2
chr18_-_42262053	0.560	ENSMUST00000097590.3	Lars	leucyl-tRNA synthetase
chr11_-_118290167	0.552	ENSMUST00000144153.1	Usp36	ubiquitin specific peptidase 36
chr11_-_75422524	0.549	ENSMUST00000125982.1 ENSMUST00000137103.1	Serpinf1	serine (or cysteine) peptidase inhibitor, clade F, member 1
chr19_-_43524462	0.546	ENSMUST00000026196.7	Got1	glutamate oxaloacetate transaminase 1, soluble
chr11_-_118290188	0.530	ENSMUST00000106296.2 ENSMUST00000092382.3	Usp36	ubiquitin specific peptidase 36
chr13_-_118387224	0.526	ENSMUST00000022245.8	Mrps30	mitochondrial ribosomal protein S30
chr11_-_53430417	0.519	ENSMUST00000109019.1	Uqcrq	ubiquinol-cytochrome c reductase, complex III subunit VII
chr1_+_133131143	0.500	ENSMUST00000052529.3	Ppp1r15b	protein phosphatase 1, regulatory (inhibitor) subunit 15b
chr17_-_34187219	0.497	ENSMUST00000173831.1	Psmb9	proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
chr7_-_126502312	0.497	ENSMUST00000166682.2	Atxn2l	ataxin 2-like
chr4_-_118179628	0.491	ENSMUST00000097911.2	Kdm4a	lysine (K)-specific demethylase 4A
chr12_-_104865076	0.481	ENSMUST00000109937.1 ENSMUST00000109936.1	Clmn	calmin
chr3_-_138143352	0.463	ENSMUST00000098580.2	Mttp	microsomal triglyceride transfer protein
chr15_+_99393574	0.433	ENSMUST00000162624.1	Tmbim6	transmembrane BAX inhibitor motif containing 6
chr7_+_110018301	0.429	ENSMUST00000084731.3	Ipo7	importin 7
chr5_-_36695969	0.417	ENSMUST00000031091.9 ENSMUST00000140063.1	D5Ertd579e	DNA segment, Chr 5, ERATO Doi 579, expressed
chr11_-_98400393	0.409	ENSMUST00000128897.1	Pgap3	post-GPI attachment to proteins 3
chr9_-_71771535	0.397	ENSMUST00000122065.1 ENSMUST00000121322.1 ENSMUST00000072899.2	Cgnl1	cingulin-like 1
chr15_+_82147238	0.388	ENSMUST00000023100.6	Srebf2	sterol regulatory element binding factor 2
chr1_-_36709904	0.375	ENSMUST00000043951.3	Actr1b	ARP1 actin-related protein 1B, centractin beta
chr6_-_129533267	0.369	ENSMUST00000181594.1	1700101I11Rik	RIKEN cDNA 1700101I11 gene
chr2_+_3513035	0.367	ENSMUST00000036350.2	Cdnf	cerebral dopamine neurotrophic factor
chr1_+_185363076	0.330	ENSMUST00000046514.7	Eprs	glutamyl-prolyl-tRNA synthetase
chr10_-_121626316	0.319	ENSMUST00000039810.7	Xpot	exportin, tRNA (nuclear export receptor for tRNAs)
chr8_+_105701624	0.286	ENSMUST00000093195.6	Pard6a	par-6 (partitioning defective 6,) homolog alpha (C. elegans)
chr19_-_4793851	0.264	ENSMUST00000178615.1 ENSMUST00000179189.1 ENSMUST00000164376.2 ENSMUST00000164209.2 ENSMUST00000180248.1	Rbm4	RNA binding motif protein 4
chr14_-_37135126	0.217	ENSMUST00000042564.9	Ghitm	growth hormone inducible transmembrane protein
chr19_-_40588374	0.206	ENSMUST00000175932.1 ENSMUST00000176955.1 ENSMUST00000149476.2	Aldh18a1	aldehyde dehydrogenase 18 family, member A1
chr7_-_126502380	0.205	ENSMUST00000167759.1	Atxn2l	ataxin 2-like
chr11_-_98400453	0.195	ENSMUST00000090827.5	Pgap3	post-GPI attachment to proteins 3
chr4_-_41774097	0.195	ENSMUST00000108036.1 ENSMUST00000173865.1 ENSMUST00000108037.2 ENSMUST00000108032.2	Ccl27a	chemokine (C-C motif) ligand 27A
chr15_+_99393610	0.191	ENSMUST00000159531.1	Tmbim6	transmembrane BAX inhibitor motif containing 6
chr3_-_89998656	0.175	ENSMUST00000079724.4	Hax1	HCLS1 associated X-1
chr14_-_54870913	0.168	ENSMUST00000146642.1	Homez	homeodomain leucine zipper-encoding gene
chr11_+_58009064	0.166	ENSMUST00000071487.6 ENSMUST00000178636.1	Larp1	La ribonucleoprotein domain family, member 1
chr8_-_105701077	0.009	ENSMUST00000042608.6	Acd	adrenocortical dysplasia
chr11_-_53430779	0.002	ENSMUST00000061326.4 ENSMUST00000109021.3	Uqcrq	ubiquinol-cytochrome c reductase, complex III subunit VII

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
2.6	7.9	GO:0006931	substrate-dependent cell migration, cell attachment to substrate(GO:0006931) calcium-independent cell-matrix adhesion(GO:0007161) transforming growth factor-beta secretion(GO:0038044)
1.4	5.5	GO:0006751	glutathione catabolic process(GO:0006751)
1.4	6.8	GO:0051012	microtubule sliding(GO:0051012)
1.1	4.3	GO:0015825	L-serine transport(GO:0015825)
0.8	2.5	GO:0061537	glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.8	2.4	GO:0006428	isoleucyl-tRNA aminoacylation(GO:0006428)
0.7	2.9	GO:0010808	positive regulation of synaptic vesicle priming(GO:0010808)
0.6	5.5	GO:0036371	protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.6	2.8	GO:0018364	peptidyl-glutamine methylation(GO:0018364)
0.5	1.6	GO:0042560	10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
0.4	1.6	GO:0046967	cytosol to ER transport(GO:0046967)
0.4	1.6	GO:0006421	asparaginyl-tRNA aminoacylation(GO:0006421)
0.4	1.5	GO:1903984	positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.4	1.1	GO:1900369	negative regulation of RNA interference(GO:1900369)
0.3	2.4	GO:0006561	proline biosynthetic process(GO:0006561)
0.3	2.0	GO:0021797	forebrain anterior/posterior pattern specification(GO:0021797)
0.3	1.6	GO:1904721	regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.3	1.2	GO:0006432	phenylalanyl-tRNA aminoacylation(GO:0006432)
0.3	1.5	GO:0015960	diadenosine polyphosphate biosynthetic process(GO:0015960) diadenosine tetraphosphate metabolic process(GO:0015965) diadenosine tetraphosphate biosynthetic process(GO:0015966)
0.3	1.2	GO:1904706	heme oxidation(GO:0006788) negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
0.3	0.8	GO:0035880	embryonic nail plate morphogenesis(GO:0035880) positive regulation of catagen(GO:0051795) frontal suture morphogenesis(GO:0060364)
0.3	0.8	GO:0006419	alanyl-tRNA aminoacylation(GO:0006419)
0.3	1.0	GO:1903966	monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.3	3.8	GO:0015809	arginine transport(GO:0015809)
0.2	0.7	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.2	0.7	GO:0006436	tryptophanyl-tRNA aminoacylation(GO:0006436)
0.2	1.9	GO:1902416	positive regulation of mRNA binding(GO:1902416)
0.2	0.5	GO:0006106	fumarate metabolic process(GO:0006106) aspartate biosynthetic process(GO:0006532) aspartate catabolic process(GO:0006533) alditol biosynthetic process(GO:0019401)
0.2	1.2	GO:0045876	positive regulation of sister chromatid cohesion(GO:0045876)
0.2	1.5	GO:0018095	protein polyglutamylation(GO:0018095)
0.2	4.5	GO:0006418	tRNA aminoacylation for protein translation(GO:0006418)
0.2	1.1	GO:0051204	protein insertion into mitochondrial membrane(GO:0051204)
0.2	1.4	GO:0060613	fat pad development(GO:0060613)
0.1	1.1	GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.1	1.2	GO:2000194	regulation of female gonad development(GO:2000194)
0.1	0.8	GO:0071630	nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.1	1.4	GO:0006995	cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.1	0.5	GO:0034196	acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.1	1.1	GO:0070995	NADPH oxidation(GO:0070995)
0.1	0.5	GO:0021539	subthalamus development(GO:0021539)
0.1	0.7	GO:0061368	maternal process involved in parturition(GO:0060137) behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.1	0.5	GO:1903912	negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:1903912)
0.1	1.5	GO:0010603	regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.1	0.3	GO:0006409	tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.1	0.4	GO:0010886	positive regulation of cholesterol storage(GO:0010886) regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter(GO:0072368) negative regulation of cholesterol efflux(GO:0090370)
0.1	0.8	GO:0010459	negative regulation of heart rate(GO:0010459)
0.1	1.0	GO:0070262	peptidyl-serine dephosphorylation(GO:0070262)
0.1	0.3	GO:0097167	circadian regulation of translation(GO:0097167)
0.1	1.6	GO:0031065	positive regulation of histone deacetylation(GO:0031065)
0.1	0.2	GO:0071677	positive regulation of mononuclear cell migration(GO:0071677)
0.1	0.9	GO:0009048	dosage compensation by inactivation of X chromosome(GO:0009048)
0.1	3.8	GO:0010718	positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.1	0.2	GO:1901355	response to rapamycin(GO:1901355)
0.0	0.7	GO:1904262	negative regulation of TORC1 signaling(GO:1904262)
0.0	1.0	GO:0014049	positive regulation of glutamate secretion(GO:0014049)
0.0	0.5	GO:1900113	negative regulation of histone H3-K9 trimethylation(GO:1900113)
0.0	0.2	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.0	1.5	GO:0051220	cytoplasmic sequestering of protein(GO:0051220)
0.0	0.9	GO:0046856	phosphatidylinositol dephosphorylation(GO:0046856)
0.0	1.1	GO:1903146	regulation of mitophagy(GO:1903146)
0.0	5.9	GO:0007219	Notch signaling pathway(GO:0007219)
0.0	0.1	GO:1904781	positive regulation of protein localization to centrosome(GO:1904781)
0.0	0.6	GO:0006506	GPI anchor biosynthetic process(GO:0006506)
0.0	0.7	GO:0048008	platelet-derived growth factor receptor signaling pathway(GO:0048008)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
2.6	7.9	GO:0005577	fibrinogen complex(GO:0005577)
0.6	2.9	GO:0098831	presynaptic active zone cytoplasmic component(GO:0098831)
0.4	2.8	GO:0031428	box C/D snoRNP complex(GO:0031428)
0.4	1.2	GO:0009328	phenylalanine-tRNA ligase complex(GO:0009328)
0.3	5.5	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.2	1.6	GO:0042825	TAP complex(GO:0042825)
0.2	1.9	GO:0071541	eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.2	5.5	GO:0031430	M band(GO:0031430)
0.2	1.1	GO:0044530	supraspliceosomal complex(GO:0044530)
0.1	1.2	GO:0042382	paraspeckles(GO:0042382)
0.1	1.3	GO:0005750	mitochondrial respiratory chain complex III(GO:0005750)
0.1	0.5	GO:1990111	spermatoproteasome complex(GO:1990111)
0.1	1.1	GO:0043203	axon hillock(GO:0043203)
0.1	6.8	GO:0072686	mitotic spindle(GO:0072686)
0.1	4.3	GO:0005882	intermediate filament(GO:0005882)
0.1	1.4	GO:0000421	autophagosome membrane(GO:0000421)
0.0	1.0	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	0.4	GO:0032937	SREBP-SCAP-Insig complex(GO:0032937)
0.0	0.5	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.0	0.8	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	1.0	GO:0031305	integral component of mitochondrial inner membrane(GO:0031305)
0.0	2.1	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0	0.4	GO:0005869	dynactin complex(GO:0005869)
0.0	2.0	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	0.5	GO:0031528	microvillus membrane(GO:0031528)
0.0	1.4	GO:0005881	cytoplasmic microtubule(GO:0005881)
0.0	5.5	GO:0005802	trans-Golgi network(GO:0005802)
0.0	6.0	GO:0016607	nuclear speck(GO:0016607)
0.0	0.5	GO:0005721	pericentric heterochromatin(GO:0005721)
0.0	1.5	GO:0017053	transcriptional repressor complex(GO:0017053)
0.0	3.8	GO:0000139	Golgi membrane(GO:0000139)
0.0	1.2	GO:0005901	caveola(GO:0005901)
0.0	3.5	GO:0098793	presynapse(GO:0098793)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.3	7.9	GO:0045340	mercury ion binding(GO:0045340)
1.1	5.5	GO:0003839	gamma-glutamylcyclotransferase activity(GO:0003839)
0.8	2.4	GO:0004822	isoleucine-tRNA ligase activity(GO:0004822)
0.6	2.4	GO:0004735	pyrroline-5-carboxylate reductase activity(GO:0004735)
0.5	1.6	GO:0016155	formyltetrahydrofolate dehydrogenase activity(GO:0016155)
0.5	4.3	GO:0015180	L-alanine transmembrane transporter activity(GO:0015180) L-proline transmembrane transporter activity(GO:0015193) alanine transmembrane transporter activity(GO:0022858)
0.5	1.6	GO:0004816	asparagine-tRNA ligase activity(GO:0004816)
0.5	3.8	GO:0015181	arginine transmembrane transporter activity(GO:0015181)
0.4	1.6	GO:0015433	peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
0.4	1.1	GO:0003692	left-handed Z-DNA binding(GO:0003692)
0.4	1.5	GO:0070740	tubulin-glutamic acid ligase activity(GO:0070740)
0.3	2.5	GO:0015187	glycine transmembrane transporter activity(GO:0015187)
0.3	1.2	GO:0004392	heme oxygenase (decyclizing) activity(GO:0004392)
0.3	0.9	GO:0052658	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.3	1.6	GO:0060698	endoribonuclease inhibitor activity(GO:0060698)
0.3	0.8	GO:0004813	alanine-tRNA ligase activity(GO:0004813)
0.3	1.0	GO:0032896	palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.2	1.2	GO:0004826	phenylalanine-tRNA ligase activity(GO:0004826)
0.2	1.2	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.2	0.7	GO:0004830	tryptophan-tRNA ligase activity(GO:0004830)
0.2	0.8	GO:0043125	ErbB-3 class receptor binding(GO:0043125)
0.2	0.5	GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.2	6.0	GO:0016876	aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.2	2.8	GO:0008649	rRNA methyltransferase activity(GO:0008649)
0.2	1.3	GO:0008121	ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1	1.5	GO:0050815	phosphoserine binding(GO:0050815)
0.1	5.5	GO:0030507	spectrin binding(GO:0030507)
0.1	1.4	GO:0030957	Tat protein binding(GO:0030957)
0.1	1.1	GO:0070402	NADPH binding(GO:0070402)
0.1	0.2	GO:0019966	interleukin-1 binding(GO:0019966)
0.0	0.7	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	4.1	GO:0048306	calcium-dependent protein binding(GO:0048306)
0.0	2.1	GO:0031369	translation initiation factor binding(GO:0031369)
0.0	0.7	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.5	GO:0034185	apolipoprotein binding(GO:0034185)
0.0	5.5	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0	0.5	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454) histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	1.1	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.0	2.2	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0	0.3	GO:0097157	pre-mRNA intronic binding(GO:0097157)
0.0	6.7	GO:0008017	microtubule binding(GO:0008017)
0.0	1.4	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.0	0.5	GO:0004298	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) proteasome binding(GO:0070628)
0.0	2.9	GO:0017137	Rab GTPase binding(GO:0017137)
0.0	0.9	GO:0003743	translation initiation factor activity(GO:0003743)
0.0	1.5	GO:0019888	protein phosphatase regulator activity(GO:0019888)
0.0	0.7	GO:0008536	Ran GTPase binding(GO:0008536)
0.0	1.2	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0	0.7	GO:0004601	peroxidase activity(GO:0004601)
0.0	1.1	GO:0008565	protein transporter activity(GO:0008565)
0.0	0.0	GO:0017084	glutamate 5-kinase activity(GO:0004349) glutamate-5-semialdehyde dehydrogenase activity(GO:0004350) delta1-pyrroline-5-carboxylate synthetase activity(GO:0017084) amino acid kinase activity(GO:0019202)

Gene overrepresentation in C2:CP category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	7.9	PID_INTEGRIN5_PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1	3.9	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	PI3K Pathway
0.1	0.8	PID_IL5_PATHWAY	IL5-mediated signaling events
0.0	1.4	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0	1.2	PID_FRA_PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0	1.9	PID_ATF2_PATHWAY	ATF-2 transcription factor network
0.0	0.7	PID_ARF6_DOWNSTREAM_PATHWAY	Arf6 downstream pathway
0.0	2.7	PID_P53_DOWNSTREAM_PATHWAY	Direct p53 effectors
0.0	0.4	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.6	7.9	REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins
0.4	11.0	REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.3	2.9	REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE	Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.3	2.5	REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.2	8.1	REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.2	5.9	REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS	Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1	1.5	REACTOME_RAF_MAP_KINASE_CASCADE	Genes involved in RAF/MAP kinase cascade
0.1	1.4	REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.1	1.6	REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1	2.2	REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.1	0.8	REACTOME_IL_7_SIGNALING	Genes involved in Interleukin-7 signaling
0.1	1.2	REACTOME_N_GLYCAN_ANTENNAE_ELONGATION	Genes involved in N-Glycan antennae elongation
0.0	1.0	REACTOME_CRMPS_IN_SEMA3A_SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.0	1.9	REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0	0.5	REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.0	1.2	REACTOME_IRON_UPTAKE_AND_TRANSPORT	Genes involved in Iron uptake and transport
0.0	1.1	REACTOME_INTERFERON_ALPHA_BETA_SIGNALING	Genes involved in Interferon alpha/beta signaling
0.0	1.3	REACTOME_RESPIRATORY_ELECTRON_TRANSPORT	Genes involved in Respiratory electron transport

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