Motif ID: Atf4

Z-value: 0.921


Transcription factors associated with Atf4:

Gene SymbolEntrez IDGene Name
Atf4 ENSMUSG00000042406.7 Atf4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Atf4mm10_v2_chr15_+_80255184_80255263-0.162.4e-01Click!


Activity profile for motif Atf4.

activity profile for motif Atf4


Sorted Z-values histogram for motif Atf4

Sorted Z-values for motif Atf4



Network of associatons between targets according to the STRING database.



First level regulatory network of Atf4

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 111 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_71653162 7.948 ENSMUST00000055226.6
 Fn1
fibronectin 1
chrX_+_103422010 6.718 ENSMUST00000182089.1
 Gm26992
predicted gene, 26992
chr19_-_12501996 5.888 ENSMUST00000045521.7
 Dtx4
deltex 4 homolog (Drosophila)
chr2_+_119351222 5.489 ENSMUST00000028780.3
 Chac1
ChaC, cation transport regulator 1
chr9_+_109931774 4.045 ENSMUST00000169851.2
 Map4
microtubule-associated protein 4
chr5_-_148399901 3.843 ENSMUST00000048116.8
 Slc7a1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr4_+_43957678 3.800 ENSMUST00000107855.1
 Glipr2
GLI pathogenesis-related 2
chr1_-_22315792 2.882 ENSMUST00000164877.1
 Rims1
regulating synaptic membrane exocytosis 1
chr11_-_35798884 2.834 ENSMUST00000160726.2
 Fbll1
fibrillarin-like 1
chrX_-_162565514 2.610 ENSMUST00000154424.1
 Reps2
RALBP1 associated Eps domain containing protein 2
chr4_+_117835387 2.527 ENSMUST00000169885.1
 Slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr11_-_120643643 2.393 ENSMUST00000141254.1
ENSMUST00000170556.1
ENSMUST00000151876.1
ENSMUST00000026133.8
ENSMUST00000139706.1
 Pycr1




pyrroline-5-carboxylate reductase 1




chr11_-_20332689 2.181 ENSMUST00000109594.1
 Slc1a4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr11_-_20332654 2.107 ENSMUST00000004634.6
 Slc1a4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr6_-_23248264 1.994 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr7_-_126566364 1.907 ENSMUST00000032992.5
 Eif3c
eukaryotic translation initiation factor 3, subunit C
chr4_-_129189600 1.732 ENSMUST00000117497.1
ENSMUST00000117350.1
 S100pbp

S100P binding protein

chr13_+_49682191 1.683 ENSMUST00000172254.1
 Iars
isoleucine-tRNA synthetase
chr10_-_83533383 1.618 ENSMUST00000146640.1
 Aldh1l2
aldehyde dehydrogenase 1 family, member L2
chr18_-_64516547 1.592 ENSMUST00000025483.9
 Nars
asparaginyl-tRNA synthetase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.6 7.9 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931) calcium-independent cell-matrix adhesion(GO:0007161) transforming growth factor-beta secretion(GO:0038044)
1.4 6.8 GO:0051012 microtubule sliding(GO:0051012)
0.0 5.9 GO:0007219 Notch signaling pathway(GO:0007219)
1.4 5.5 GO:0006751 glutathione catabolic process(GO:0006751)
0.6 5.5 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.2 4.5 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
1.1 4.3 GO:0015825 L-serine transport(GO:0015825)
0.3 3.8 GO:0015809 arginine transport(GO:0015809)
0.1 3.8 GO:0010718 positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.7 2.9 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.6 2.8 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
0.8 2.5 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.8 2.4 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.3 2.4 GO:0006561 proline biosynthetic process(GO:0006561)
0.3 2.0 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.2 1.9 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.5 1.6 GO:0042560 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
0.4 1.6 GO:0046967 cytosol to ER transport(GO:0046967)
0.4 1.6 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.3 1.6 GO:1904721 regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.6 7.9 GO:0005577 fibrinogen complex(GO:0005577)
0.1 6.8 GO:0072686 mitotic spindle(GO:0072686)
0.0 6.0 GO:0016607 nuclear speck(GO:0016607)
0.3 5.5 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.2 5.5 GO:0031430 M band(GO:0031430)
0.0 5.5 GO:0005802 trans-Golgi network(GO:0005802)
0.1 4.3 GO:0005882 intermediate filament(GO:0005882)
0.0 3.8 GO:0000139 Golgi membrane(GO:0000139)
0.0 3.5 GO:0098793 presynapse(GO:0098793)
0.6 2.9 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
0.4 2.8 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 2.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 2.0 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.2 1.9 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.2 1.6 GO:0042825 TAP complex(GO:0042825)
0.0 1.5 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 1.4 GO:0000421 autophagosome membrane(GO:0000421)
0.0 1.4 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 1.3 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.4 1.2 GO:0009328 phenylalanine-tRNA ligase complex(GO:0009328)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 7.9 GO:0045340 mercury ion binding(GO:0045340)
0.0 6.7 GO:0008017 microtubule binding(GO:0008017)
0.2 6.0 GO:0016876 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
1.1 5.5 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.1 5.5 GO:0030507 spectrin binding(GO:0030507)
0.0 5.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.5 4.3 GO:0015180 L-alanine transmembrane transporter activity(GO:0015180) L-proline transmembrane transporter activity(GO:0015193) alanine transmembrane transporter activity(GO:0022858)
0.0 4.1 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.5 3.8 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.0 2.9 GO:0017137 Rab GTPase binding(GO:0017137)
0.2 2.8 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.3 2.5 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.8 2.4 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.6 2.4 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.0 2.2 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 2.1 GO:0031369 translation initiation factor binding(GO:0031369)
0.5 1.6 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
0.5 1.6 GO:0004816 asparagine-tRNA ligase activity(GO:0004816)
0.4 1.6 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
0.3 1.6 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 7.9 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 3.9 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY PI3K Pathway
0.0 2.7 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 1.9 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 1.4 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 1.2 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 0.8 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.7 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.4 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 11.0 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.2 8.1 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.6 7.9 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.2 5.9 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.3 2.9 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.3 2.5 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 2.2 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 1.9 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 1.6 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 1.5 REACTOME_RAF_MAP_KINASE_CASCADE Genes involved in RAF/MAP kinase cascade
0.1 1.4 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 1.3 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.1 1.2 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 1.2 REACTOME_IRON_UPTAKE_AND_TRANSPORT Genes involved in Iron uptake and transport
0.0 1.1 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 1.0 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 0.8 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.5 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport