Motif ID: Atf5
Z-value: 0.657
Transcription factors associated with Atf5:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Atf5 | ENSMUSG00000038539.8 | Atf5 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Atf5 | mm10_v2_chr7_-_44816586_44816658 | -0.04 | 7.5e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 3.1 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.5 | 1.5 | GO:0018103 | protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406) |
| 0.4 | 1.2 | GO:1904339 | negative regulation of dopaminergic neuron differentiation(GO:1904339) |
| 0.4 | 0.7 | GO:0010808 | positive regulation of synaptic vesicle priming(GO:0010808) |
| 0.3 | 1.1 | GO:1990743 | protein sialylation(GO:1990743) |
| 0.3 | 0.8 | GO:2000620 | positive regulation of histone H4-K16 acetylation(GO:2000620) |
| 0.2 | 0.7 | GO:1903225 | negative regulation of endodermal cell differentiation(GO:1903225) |
| 0.2 | 2.0 | GO:0098700 | neurotransmitter loading into synaptic vesicle(GO:0098700) |
| 0.2 | 2.0 | GO:0030035 | microspike assembly(GO:0030035) |
| 0.2 | 1.2 | GO:0099525 | presynaptic dense core granule exocytosis(GO:0099525) |
| 0.2 | 1.0 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.2 | 0.8 | GO:1902268 | negative regulation of polyamine transmembrane transport(GO:1902268) |
| 0.2 | 0.9 | GO:0035989 | tendon development(GO:0035989) |
| 0.1 | 7.2 | GO:0001919 | regulation of receptor recycling(GO:0001919) |
| 0.1 | 0.9 | GO:0048341 | paraxial mesoderm formation(GO:0048341) |
| 0.1 | 0.4 | GO:0046340 | diacylglycerol catabolic process(GO:0046340) |
| 0.1 | 1.3 | GO:0010793 | regulation of mRNA export from nucleus(GO:0010793) |
| 0.1 | 0.4 | GO:0044333 | Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041) |
| 0.1 | 1.1 | GO:0099590 | neurotransmitter receptor internalization(GO:0099590) |
| 0.1 | 1.1 | GO:0031339 | negative regulation of vesicle fusion(GO:0031339) |
| 0.1 | 0.8 | GO:0038180 | nerve growth factor signaling pathway(GO:0038180) |
| 0.1 | 1.0 | GO:0032876 | negative regulation of DNA endoreduplication(GO:0032876) |
| 0.1 | 0.5 | GO:0010626 | negative regulation of Schwann cell proliferation(GO:0010626) |
| 0.1 | 0.6 | GO:0035754 | B cell chemotaxis(GO:0035754) |
| 0.1 | 0.9 | GO:0060536 | cartilage morphogenesis(GO:0060536) |
| 0.1 | 0.3 | GO:0032632 | interleukin-3 production(GO:0032632) |
| 0.1 | 0.5 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.1 | 1.0 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
| 0.1 | 0.3 | GO:0042138 | meiotic DNA double-strand break formation(GO:0042138) |
| 0.1 | 0.6 | GO:0010606 | positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606) |
| 0.1 | 0.4 | GO:0046549 | retinal cone cell development(GO:0046549) |
| 0.1 | 0.2 | GO:0003219 | cardiac right ventricle formation(GO:0003219) |
| 0.1 | 0.2 | GO:0002182 | cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248) |
| 0.1 | 0.3 | GO:0035720 | intraciliary anterograde transport(GO:0035720) |
| 0.1 | 2.1 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.1 | 0.6 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
| 0.0 | 1.1 | GO:0090129 | positive regulation of synapse maturation(GO:0090129) |
| 0.0 | 1.6 | GO:0014912 | negative regulation of smooth muscle cell migration(GO:0014912) |
| 0.0 | 0.2 | GO:0007113 | endomitotic cell cycle(GO:0007113) |
| 0.0 | 0.7 | GO:0021902 | commitment of neuronal cell to specific neuron type in forebrain(GO:0021902) |
| 0.0 | 0.5 | GO:2000741 | positive regulation of mesenchymal stem cell differentiation(GO:2000741) |
| 0.0 | 1.9 | GO:0071300 | cellular response to retinoic acid(GO:0071300) |
| 0.0 | 0.4 | GO:1901409 | positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
| 0.0 | 0.9 | GO:0039703 | viral RNA genome replication(GO:0039694) RNA replication(GO:0039703) |
| 0.0 | 0.1 | GO:0016344 | meiotic chromosome movement towards spindle pole(GO:0016344) |
| 0.0 | 0.6 | GO:0015693 | magnesium ion transport(GO:0015693) |
| 0.0 | 0.7 | GO:0045662 | negative regulation of myoblast differentiation(GO:0045662) |
| 0.0 | 0.2 | GO:0042701 | progesterone secretion(GO:0042701) |
| 0.0 | 0.3 | GO:1990118 | sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118) |
| 0.0 | 0.3 | GO:0021940 | positive regulation of cerebellar granule cell precursor proliferation(GO:0021940) |
| 0.0 | 0.3 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
| 0.0 | 0.5 | GO:0051205 | protein insertion into membrane(GO:0051205) |
| 0.0 | 1.9 | GO:0060976 | coronary vasculature development(GO:0060976) |
| 0.0 | 0.1 | GO:0035405 | histone-threonine phosphorylation(GO:0035405) |
| 0.0 | 1.2 | GO:0046580 | negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058) |
| 0.0 | 0.7 | GO:0006730 | one-carbon metabolic process(GO:0006730) |
| 0.0 | 0.3 | GO:0016558 | protein import into peroxisome matrix(GO:0016558) |
| 0.0 | 0.4 | GO:0003170 | heart valve development(GO:0003170) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 7.2 | GO:0043083 | synaptic cleft(GO:0043083) |
| 0.2 | 0.7 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 0.1 | 3.1 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.1 | 0.7 | GO:0098831 | presynaptic active zone cytoplasmic component(GO:0098831) |
| 0.1 | 0.9 | GO:0044308 | axonal spine(GO:0044308) |
| 0.1 | 0.8 | GO:0070531 | BRCA1-A complex(GO:0070531) |
| 0.1 | 1.3 | GO:0000347 | THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) |
| 0.1 | 1.2 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.1 | 1.2 | GO:1990909 | Wnt signalosome(GO:1990909) |
| 0.1 | 1.5 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.1 | 2.0 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.1 | 0.3 | GO:1990415 | Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429) |
| 0.1 | 0.8 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.1 | 1.2 | GO:0031045 | dense core granule(GO:0031045) |
| 0.1 | 0.6 | GO:0030015 | CCR4-NOT core complex(GO:0030015) |
| 0.1 | 0.9 | GO:0032584 | growth cone membrane(GO:0032584) |
| 0.1 | 0.3 | GO:0070820 | tertiary granule(GO:0070820) |
| 0.1 | 0.6 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.1 | 0.5 | GO:0031315 | extrinsic component of mitochondrial outer membrane(GO:0031315) |
| 0.0 | 1.5 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.0 | 0.5 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.0 | 0.8 | GO:0033270 | paranode region of axon(GO:0033270) |
| 0.0 | 0.1 | GO:0071437 | invadopodium(GO:0071437) |
| 0.0 | 1.1 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.0 | 0.3 | GO:0005922 | connexon complex(GO:0005922) |
| 0.0 | 0.3 | GO:1904949 | ATPase complex(GO:1904949) |
| 0.0 | 0.3 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.0 | 0.4 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.0 | 0.2 | GO:0071598 | neuronal ribonucleoprotein granule(GO:0071598) |
| 0.0 | 1.6 | GO:0030175 | filopodium(GO:0030175) |
| 0.0 | 0.2 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
| 0.0 | 0.9 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 0.5 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 0.4 | GO:0016592 | mediator complex(GO:0016592) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 7.2 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 0.2 | 0.8 | GO:0008073 | ornithine decarboxylase inhibitor activity(GO:0008073) |
| 0.2 | 1.1 | GO:0003828 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828) |
| 0.1 | 0.4 | GO:0008502 | melatonin receptor activity(GO:0008502) |
| 0.1 | 0.8 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.1 | 2.0 | GO:0005313 | L-glutamate transmembrane transporter activity(GO:0005313) |
| 0.1 | 0.4 | GO:0042134 | rRNA primary transcript binding(GO:0042134) |
| 0.1 | 3.1 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.1 | 1.5 | GO:0034236 | protein kinase A catalytic subunit binding(GO:0034236) |
| 0.1 | 0.3 | GO:0061505 | DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505) |
| 0.1 | 1.6 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.1 | 0.6 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
| 0.1 | 1.5 | GO:0000030 | mannosyltransferase activity(GO:0000030) |
| 0.1 | 0.7 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.1 | 0.3 | GO:0017116 | single-stranded DNA-dependent ATP-dependent DNA helicase activity(GO:0017116) |
| 0.1 | 0.4 | GO:0001515 | opioid peptide activity(GO:0001515) |
| 0.1 | 0.9 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.0 | 0.6 | GO:0015299 | solute:proton antiporter activity(GO:0015299) |
| 0.0 | 0.9 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.0 | 0.1 | GO:0035402 | histone kinase activity (H3-T11 specific)(GO:0035402) |
| 0.0 | 1.3 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 0.6 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.0 | 1.5 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 0.5 | GO:0016594 | glycine binding(GO:0016594) |
| 0.0 | 0.6 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.0 | 1.4 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 0.0 | 0.6 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.0 | 0.4 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.0 | 1.2 | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding(GO:0005546) |
| 0.0 | 1.1 | GO:0030276 | clathrin binding(GO:0030276) |
| 0.0 | 1.0 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.0 | 0.9 | GO:0005179 | hormone activity(GO:0005179) |
| 0.0 | 0.2 | GO:0008641 | small protein activating enzyme activity(GO:0008641) |
| 0.0 | 0.2 | GO:0005326 | neurotransmitter transporter activity(GO:0005326) |
| 0.0 | 1.8 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 1.0 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.0 | 0.4 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.0 | 0.5 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.9 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.1 | 2.3 | PID_INSULIN_GLUCOSE_PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 1.3 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 0.8 | PID_ARF6_PATHWAY | Arf6 signaling events |
| 0.0 | 0.9 | PID_ECADHERIN_STABILIZATION_PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 0.6 | PID_EPHA_FWDPATHWAY | EPHA forward signaling |
| 0.0 | 0.2 | PID_ERB_GENOMIC_PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 1.4 | PID_RB_1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 1.0 | PID_PLK1_PATHWAY | PLK1 signaling events |
| 0.0 | 2.1 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 1.6 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 0.7 | PID_AP1_PATHWAY | AP-1 transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 8.4 | REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.1 | 3.0 | REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.1 | 0.6 | REACTOME_ENDOGENOUS_STEROLS | Genes involved in Endogenous sterols |
| 0.1 | 0.7 | REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
| 0.1 | 1.6 | REACTOME_OTHER_SEMAPHORIN_INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.0 | 0.8 | REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.0 | 0.9 | REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.0 | 0.7 | REACTOME_N_GLYCAN_ANTENNAE_ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.0 | 2.0 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.0 | 0.6 | REACTOME_PECAM1_INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.0 | 0.8 | REACTOME_NEPHRIN_INTERACTIONS | Genes involved in Nephrin interactions |
| 0.0 | 2.0 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 0.4 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 0.7 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 1.0 | REACTOME_MEIOTIC_SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.0 | 0.8 | REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.0 | 0.3 | REACTOME_METAL_ION_SLC_TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.0 | 0.4 | REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.0 | 0.1 | REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
