Motif ID: Atf5

Z-value: 0.657


Transcription factors associated with Atf5:

Gene SymbolEntrez IDGene Name
Atf5 ENSMUSG00000038539.8 Atf5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Atf5mm10_v2_chr7_-_44816586_44816658-0.047.5e-01Click!


Activity profile for motif Atf5.

activity profile for motif Atf5


Sorted Z-values histogram for motif Atf5

Sorted Z-values for motif Atf5



Network of associatons between targets according to the STRING database.



First level regulatory network of Atf5

PNG image of the network

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Top targets:


Showing 1 to 20 of 117 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_82705735 3.082 ENSMUST00000155821.1
 Nfib
nuclear factor I/B
chrX_+_41401128 2.765 ENSMUST00000115103.2
 Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chrX_+_41401304 2.582 ENSMUST00000076349.5
 Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chr16_+_43503607 2.202 ENSMUST00000126100.1
ENSMUST00000123047.1
ENSMUST00000156981.1
 Zbtb20


zinc finger and BTB domain containing 20


chr13_+_104287855 2.055 ENSMUST00000065766.6
 Adamts6
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6
chr7_+_51621830 2.022 ENSMUST00000032710.5
 Slc17a6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chrX_+_41401476 1.884 ENSMUST00000165288.1
 Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chr4_-_91376433 1.613 ENSMUST00000107109.2
ENSMUST00000107111.2
ENSMUST00000107120.1
 Elavl2


ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)


chr2_+_124610573 1.604 ENSMUST00000103239.3
ENSMUST00000103240.2
 Sema6d

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D

chr4_-_11322109 1.524 ENSMUST00000084892.5
ENSMUST00000128024.1
 Dpy19l4

dpy-19-like 4 (C. elegans)

chr18_-_23041641 1.521 ENSMUST00000097651.3
 Nol4
nucleolar protein 4
chr4_+_86748526 1.499 ENSMUST00000082026.7
ENSMUST00000045512.8
 Dennd4c

DENN/MADD domain containing 4C

chrX_-_41911877 1.439 ENSMUST00000047037.8
 Thoc2
THO complex 2
chr15_-_102529025 1.350 ENSMUST00000096143.1
 Atf7
activating transcription factor 7
chr1_-_158356258 1.329 ENSMUST00000004133.8
 Brinp2
bone morphogenic protein/retinoic acid inducible neural-specific 2
chr5_+_149678224 1.293 ENSMUST00000100404.3
 B3galtl
beta 1,3-galactosyltransferase-like
chr14_-_12823031 1.228 ENSMUST00000067491.6
ENSMUST00000177814.1
ENSMUST00000112658.1
ENSMUST00000112657.2
 Cadps



Ca2+-dependent secretion activator



chr1_-_157256682 1.227 ENSMUST00000134543.1
 Rasal2
RAS protein activator like 2
chr16_+_38089001 1.178 ENSMUST00000023507.6
 Gsk3b
glycogen synthase kinase 3 beta
chr10_+_115384951 1.136 ENSMUST00000036044.8
 Zfc3h1
zinc finger, C3H1-type containing

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.2 GO:0001919 regulation of receptor recycling(GO:0001919)
0.8 3.1 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.1 2.1 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.2 2.0 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.2 2.0 GO:0030035 microspike assembly(GO:0030035)
0.0 1.9 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 1.9 GO:0060976 coronary vasculature development(GO:0060976)
0.0 1.6 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.5 1.5 GO:0018103 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.1 1.3 GO:0010793 regulation of mRNA export from nucleus(GO:0010793)
0.4 1.2 GO:1904339 negative regulation of dopaminergic neuron differentiation(GO:1904339)
0.2 1.2 GO:0099525 presynaptic dense core granule exocytosis(GO:0099525)
0.0 1.2 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.3 1.1 GO:1990743 protein sialylation(GO:1990743)
0.1 1.1 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.1 1.1 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.0 1.1 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.2 1.0 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.1 1.0 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.1 1.0 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 7.2 GO:0043083 synaptic cleft(GO:0043083)
0.1 3.1 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 2.0 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 1.6 GO:0030175 filopodium(GO:0030175)
0.1 1.5 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 1.5 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 1.3 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.1 1.2 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 1.2 GO:1990909 Wnt signalosome(GO:1990909)
0.1 1.2 GO:0031045 dense core granule(GO:0031045)
0.0 1.1 GO:0030131 clathrin adaptor complex(GO:0030131)
0.1 0.9 GO:0044308 axonal spine(GO:0044308)
0.1 0.9 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.9 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 0.8 GO:0070531 BRCA1-A complex(GO:0070531)
0.1 0.8 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.8 GO:0033270 paranode region of axon(GO:0033270)
0.2 0.7 GO:0005588 collagen type V trimer(GO:0005588)
0.1 0.7 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
0.1 0.6 GO:0030015 CCR4-NOT core complex(GO:0030015)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 7.2 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 3.1 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 2.0 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.0 1.8 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 1.6 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 1.5 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.1 1.5 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 1.5 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 1.4 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 1.3 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 1.2 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.2 1.1 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 1.1 GO:0030276 clathrin binding(GO:0030276)
0.0 1.0 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 1.0 GO:0003777 microtubule motor activity(GO:0003777)
0.1 0.9 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.9 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 0.9 GO:0005179 hormone activity(GO:0005179)
0.2 0.8 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.1 0.8 GO:0070699 type II activin receptor binding(GO:0070699)

Gene overrepresentation in C2:CP category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.9 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 2.3 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 2.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.6 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.4 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.0 1.3 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.0 PID_PLK1_PATHWAY PLK1 signaling events
0.0 0.9 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.8 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.7 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 0.6 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.2 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 8.4 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 3.0 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 2.0 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 2.0 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 1.6 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 1.0 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.9 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.8 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.8 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 0.8 REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.1 0.7 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.7 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.7 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 0.6 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.0 0.6 REACTOME_PECAM1_INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.4 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.4 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.3 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.1 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors