Motif ID: Atf6

Z-value: 1.343


Transcription factors associated with Atf6:

Gene SymbolEntrez IDGene Name
Atf6 ENSMUSG00000026663.6 Atf6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Atf6mm10_v2_chr1_-_170867761_170867784-0.028.8e-01Click!


Activity profile for motif Atf6.

activity profile for motif Atf6


Sorted Z-values histogram for motif Atf6

Sorted Z-values for motif Atf6



Network of associatons between targets according to the STRING database.



First level regulatory network of Atf6

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_-_23988852 15.030 ENSMUST00000023151.5
 Bcl6
B cell leukemia/lymphoma 6
chr3_+_123267445 14.516 ENSMUST00000047923.7
 Sec24d
Sec24 related gene family, member D (S. cerevisiae)
chr8_+_125995102 13.795 ENSMUST00000046765.8
 Kcnk1
potassium channel, subfamily K, member 1
chr12_+_82616885 12.178 ENSMUST00000161801.1
 Rgs6
regulator of G-protein signaling 6
chr16_+_41532999 9.262 ENSMUST00000099761.3
 Lsamp
limbic system-associated membrane protein
chr5_+_137288273 9.096 ENSMUST00000024099.4
ENSMUST00000085934.3
 Ache

acetylcholinesterase

chr5_-_89883321 8.867 ENSMUST00000163159.1
ENSMUST00000061427.5
 Adamts3

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3

chr6_-_136173492 8.812 ENSMUST00000111905.1
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr6_-_126740151 8.806 ENSMUST00000112242.1
 Kcna6
potassium voltage-gated channel, shaker-related, subfamily, member 6
chrX_+_41401128 8.580 ENSMUST00000115103.2
 Gria3
glutamate receptor, ionotropic, AMPA3 (alpha 3)
chr5_+_134986191 8.125 ENSMUST00000094245.2
 Cldn3
claudin 3
chr8_-_70487314 7.424 ENSMUST00000045286.7
 Tmem59l
transmembrane protein 59-like
chr6_+_77242644 7.367 ENSMUST00000159616.1
 Lrrtm1
leucine rich repeat transmembrane neuronal 1
chr6_+_77242715 7.209 ENSMUST00000161677.1
 Lrrtm1
leucine rich repeat transmembrane neuronal 1
chr5_-_136170634 7.117 ENSMUST00000041048.1
 Orai2
ORAI calcium release-activated calcium modulator 2
chr6_-_8778439 6.247 ENSMUST00000115520.1
ENSMUST00000038403.5
ENSMUST00000115518.1
 Ica1


islet cell autoantigen 1


chr10_-_18743691 6.101 ENSMUST00000019999.5
 D10Bwg1379e
DNA segment, Chr 10, Brigham & Women's Genetics 1379 expressed
chr6_-_8778106 6.016 ENSMUST00000151758.1
ENSMUST00000115519.1
ENSMUST00000153390.1
 Ica1


islet cell autoantigen 1


chr15_+_77084367 5.774 ENSMUST00000181870.1
 1700109K24Rik
RIKEN cDNA 1700109K24 gene
chr15_-_77956658 5.667 ENSMUST00000117725.1
ENSMUST00000016696.6
 Foxred2

FAD-dependent oxidoreductase domain containing 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 195 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 16.8 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.7 16.0 GO:0002091 negative regulation of receptor internalization(GO:0002091)
5.0 15.0 GO:0043379 memory T cell differentiation(GO:0043379) negative regulation of isotype switching to IgE isotypes(GO:0048294)
2.3 13.7 GO:0060075 regulation of resting membrane potential(GO:0060075)
0.7 13.4 GO:0035641 locomotory exploration behavior(GO:0035641)
0.6 12.0 GO:0002115 store-operated calcium entry(GO:0002115)
0.4 11.3 GO:0043496 regulation of protein homodimerization activity(GO:0043496)
0.2 11.2 GO:0001881 receptor recycling(GO:0001881)
1.8 10.7 GO:0019695 choline metabolic process(GO:0019695)
0.4 10.6 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.0 9.1 GO:0043547 positive regulation of GTPase activity(GO:0043547)
1.8 8.9 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
2.2 8.8 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
1.0 8.8 GO:0090166 Golgi disassembly(GO:0090166)
0.1 8.6 GO:0071805 potassium ion transmembrane transport(GO:0071805)
1.0 8.1 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.9 8.1 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.6 7.2 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.8 7.1 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.2 6.9 GO:0007094 mitotic spindle assembly checkpoint(GO:0007094) spindle assembly checkpoint(GO:0071173)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 94 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 29.7 GO:0030426 growth cone(GO:0030426)
1.8 26.5 GO:0043083 synaptic cleft(GO:0043083)
0.4 18.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.4 16.8 GO:0043034 costamere(GO:0043034)
0.0 16.4 GO:0005794 Golgi apparatus(GO:0005794)
1.1 16.3 GO:0030127 COPII vesicle coat(GO:0030127)
3.4 13.8 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.2 13.7 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.2 13.2 GO:0005657 replication fork(GO:0005657)
0.2 12.6 GO:0031201 SNARE complex(GO:0031201)
0.2 11.7 GO:0030667 secretory granule membrane(GO:0030667)
0.0 11.7 GO:0097060 synaptic membrane(GO:0097060)
0.0 8.7 GO:0000139 Golgi membrane(GO:0000139)
1.2 8.3 GO:0005827 polar microtubule(GO:0005827)
0.4 8.1 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 7.8 GO:0043209 myelin sheath(GO:0043209)
0.1 7.6 GO:0031594 neuromuscular junction(GO:0031594)
0.4 6.0 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.4 5.5 GO:0044754 autolysosome(GO:0044754)
0.4 5.3 GO:0097449 astrocyte projection(GO:0097449)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 129 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 17.0 GO:0004860 protein kinase inhibitor activity(GO:0004860)
1.3 15.0 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
1.2 13.7 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 13.3 GO:0005096 GTPase activator activity(GO:0005096)
0.0 13.3 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.1 11.0 GO:0000149 SNARE binding(GO:0000149)
0.9 10.9 GO:0015279 store-operated calcium channel activity(GO:0015279)
2.7 10.7 GO:0004104 cholinesterase activity(GO:0004104) choline binding(GO:0033265)
1.5 8.8 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.5 8.8 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
2.2 8.7 GO:0005483 soluble NSF attachment protein activity(GO:0005483)
1.2 8.6 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 8.5 GO:0004175 endopeptidase activity(GO:0004175)
0.2 8.1 GO:0015459 potassium channel regulator activity(GO:0015459)
0.4 7.7 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.2 7.2 GO:0005158 insulin receptor binding(GO:0005158)
1.8 7.1 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.2 6.5 GO:0005484 SNAP receptor activity(GO:0005484)
0.2 6.1 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 6.0 GO:0008017 microtubule binding(GO:0008017)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 18.2 PID_FOXO_PATHWAY FoxO family signaling
0.2 9.5 PID_ERBB4_PATHWAY ErbB4 signaling events
0.1 6.5 PID_SHP2_PATHWAY SHP2 signaling
0.4 6.4 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 5.0 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 4.9 PID_LKB1_PATHWAY LKB1 signaling events
0.2 4.8 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.1 4.3 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 4.2 PID_ARF_3PATHWAY Arf1 pathway
0.2 3.9 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.1 2.8 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.1 2.5 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.1 2.4 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 2.4 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 2.4 PID_ERBB1_DOWNSTREAM_PATHWAY ErbB1 downstream signaling
0.1 2.3 PID_AP1_PATHWAY AP-1 transcription factor network
0.1 2.1 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 1.8 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.0 1.7 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.3 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 17.4 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.8 16.0 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
2.0 13.7 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.3 12.2 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.5 12.0 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.1 10.7 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 9.3 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.3 9.2 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.2 8.8 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 7.4 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.5 6.1 REACTOME_COPI_MEDIATED_TRANSPORT Genes involved in COPI Mediated Transport
0.2 6.0 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 5.8 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.7 5.6 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 4.5 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.5 4.0 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.3 4.0 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.1 3.7 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.3 3.5 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.5 3.0 REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport