Motif ID: Atf7_E4f1

Z-value: 1.445

Transcription factors associated with Atf7_E4f1:

Gene SymbolEntrez IDGene Name
Atf7 ENSMUSG00000052414.9 Atf7
Atf7 ENSMUSG00000071584.1 Atf7
E4f1 ENSMUSG00000024137.8 E4f1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Atf7mm10_v2_chr15_-_102529025_102529025-0.331.5e-02Click!
E4f1mm10_v2_chr17_-_24455265_24455345-0.162.3e-01Click!


Activity profile for motif Atf7_E4f1.

activity profile for motif Atf7_E4f1


Sorted Z-values histogram for motif Atf7_E4f1

Sorted Z-values for motif Atf7_E4f1



Network of associatons between targets according to the STRING database.



First level regulatory network of Atf7_E4f1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_135212557 21.829 ENSMUST00000062893.7
 Cenpe
centromere protein E
chr3_-_36571952 21.005 ENSMUST00000029270.3
 Ccna2
cyclin A2
chr8_+_116921735 18.009 ENSMUST00000034205.4
 Cenpn
centromere protein N
chr15_+_99074968 17.844 ENSMUST00000039665.6
 Troap
trophinin associated protein
chr17_-_71526819 17.724 ENSMUST00000024851.9
 Ndc80
NDC80 homolog, kinetochore complex component (S. cerevisiae)
chr2_+_105668888 16.944 ENSMUST00000111086.4
ENSMUST00000111087.3
 Pax6

paired box gene 6

chr19_+_59260878 14.482 ENSMUST00000026084.3
 Slc18a2
solute carrier family 18 (vesicular monoamine), member 2
chr3_+_40800054 13.819 ENSMUST00000168287.1
 Plk4
polo-like kinase 4
chr2_+_105668935 13.558 ENSMUST00000142772.1
 Pax6
paired box gene 6
chr6_+_113531675 13.495 ENSMUST00000036340.5
ENSMUST00000101051.2
 Fancd2

Fanconi anemia, complementation group D2

chr2_+_109280738 13.225 ENSMUST00000028527.7
 Kif18a
kinesin family member 18A
chr11_+_113619318 13.127 ENSMUST00000146390.2
ENSMUST00000106630.1
 Sstr2

somatostatin receptor 2

chrX_-_60893430 12.892 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr11_-_88718223 11.783 ENSMUST00000107909.1
 Msi2
musashi RNA-binding protein 2
chr6_-_23248264 11.730 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr3_+_127553462 11.416 ENSMUST00000043108.4
 4930422G04Rik
RIKEN cDNA 4930422G04 gene
chr3_+_67374116 10.917 ENSMUST00000061322.8
 Mlf1
myeloid leukemia factor 1
chr5_-_124032214 10.803 ENSMUST00000040967.7
 Vps37b
vacuolar protein sorting 37B (yeast)
chr5_-_106458440 10.718 ENSMUST00000086795.6
 Barhl2
BarH-like 2 (Drosophila)
chr4_+_111720187 10.544 ENSMUST00000084354.3
 Spata6
spermatogenesis associated 6

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 206 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.0 47.9 GO:0051315 attachment of mitotic spindle microtubules to kinetochore(GO:0051315)
6.1 30.5 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
0.8 23.6 GO:0034508 centromere complex assembly(GO:0034508)
3.6 21.4 GO:0046490 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate metabolic process(GO:0046490)
3.4 20.7 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
2.8 19.9 GO:0098535 positive regulation of centriole replication(GO:0046601) de novo centriole assembly(GO:0098535)
0.6 19.5 GO:0016572 histone phosphorylation(GO:0016572)
0.9 17.0 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
1.9 16.8 GO:0002318 myeloid progenitor cell differentiation(GO:0002318)
1.4 16.2 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.1 15.8 GO:0048864 stem cell development(GO:0048864)
2.4 14.5 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.7 14.2 GO:0007530 sex determination(GO:0007530)
1.9 13.5 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.7 13.2 GO:0072520 seminiferous tubule development(GO:0072520)
1.2 13.1 GO:0030432 peristalsis(GO:0030432)
3.2 12.6 GO:0045903 positive regulation of translational fidelity(GO:0045903)
0.6 12.3 GO:0044458 motile cilium assembly(GO:0044458)
4.0 12.1 GO:0051316 attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation(GO:0051316)
2.0 11.7 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 116 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 49.2 GO:0000790 nuclear chromatin(GO:0000790)
0.2 33.4 GO:0000776 kinetochore(GO:0000776)
3.1 31.4 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
0.5 26.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.6 24.2 GO:0097546 ciliary base(GO:0097546)
0.1 21.8 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
3.0 21.0 GO:0001940 male pronucleus(GO:0001940)
1.3 20.7 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
3.3 19.9 GO:0098536 deuterosome(GO:0098536)
0.3 19.7 GO:0005844 polysome(GO:0005844)
4.4 17.7 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.1 17.5 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.5 17.2 GO:0000788 nuclear nucleosome(GO:0000788)
2.3 16.2 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.2 14.1 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.9 13.7 GO:0030008 TRAPP complex(GO:0030008)
1.9 13.2 GO:0005828 kinetochore microtubule(GO:0005828)
0.7 11.1 GO:0031045 dense core granule(GO:0031045)
3.7 11.0 GO:0043224 nuclear SCF ubiquitin ligase complex(GO:0043224)
1.2 10.8 GO:0000813 ESCRT I complex(GO:0000813)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 146 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 30.5 GO:0003680 AT DNA binding(GO:0003680)
0.5 26.9 GO:0097472 cyclin-dependent protein kinase activity(GO:0097472)
0.2 26.8 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 26.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
4.4 21.8 GO:0043515 kinetochore binding(GO:0043515)
1.3 21.5 GO:0051010 microtubule plus-end binding(GO:0051010)
1.4 20.7 GO:0001054 RNA polymerase I activity(GO:0001054)
0.8 19.7 GO:0008266 poly(U) RNA binding(GO:0008266)
0.1 19.0 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.7 16.2 GO:0017160 Ral GTPase binding(GO:0017160)
4.8 14.5 GO:0008504 monoamine transmembrane transporter activity(GO:0008504)
0.0 13.7 GO:0005525 GTP binding(GO:0005525)
0.5 13.5 GO:0070182 DNA polymerase binding(GO:0070182)
4.4 13.1 GO:0004994 somatostatin receptor activity(GO:0004994)
2.1 12.6 GO:1990932 5.8S rRNA binding(GO:1990932)
1.4 11.0 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.1 10.9 GO:0042393 histone binding(GO:0042393)
2.1 10.5 GO:0032027 myosin light chain binding(GO:0032027)
0.2 10.4 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.3 10.1 GO:0008307 structural constituent of muscle(GO:0008307)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 34.6 PID_AURORA_B_PATHWAY Aurora B signaling
2.1 29.9 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.8 28.9 PID_BARD1_PATHWAY BARD1 signaling events
0.3 17.2 PID_PLK1_PATHWAY PLK1 signaling events
0.2 15.2 PID_CDC42_PATHWAY CDC42 signaling events
0.8 14.3 ST_STAT3_PATHWAY STAT3 Pathway
0.1 12.9 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.2 10.2 PID_E2F_PATHWAY E2F transcription factor network
0.4 8.4 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.4 6.3 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.2 6.0 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.3 5.9 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.2 5.4 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 4.7 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 4.2 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 3.4 PID_P53_REGULATION_PATHWAY p53 pathway
0.1 3.1 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 2.6 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.1 2.6 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 2.6 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 71 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 41.6 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
2.2 30.5 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.5 27.1 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
1.0 26.4 REACTOME_KINESINS Genes involved in Kinesins
0.3 22.1 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
1.2 21.0 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.2 20.4 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.8 19.6 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.2 18.5 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
1.0 16.2 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
1.4 14.5 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.2 14.1 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
1.3 13.5 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.4 11.9 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
1.4 10.8 REACTOME_MEMBRANE_BINDING_AND_TARGETTING_OF_GAG_PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.1 10.7 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.3 9.8 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.7 8.6 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.6 8.3 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
0.3 8.1 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation