Motif ID: Atoh1_Bhlhe23
Z-value: 0.622
Transcription factors associated with Atoh1_Bhlhe23:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Atoh1 | ENSMUSG00000073043.4 | Atoh1 |
| Bhlhe23 | ENSMUSG00000045493.3 | Bhlhe23 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Bhlhe23 | mm10_v2_chr2_-_180776900_180776900 | 0.49 | 1.3e-04 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 4.3 | GO:0060729 | intestinal epithelial structure maintenance(GO:0060729) |
| 0.6 | 2.5 | GO:2001106 | regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106) |
| 0.6 | 1.9 | GO:0061349 | Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) hypophysis morphogenesis(GO:0048850) cervix development(GO:0060067) planar cell polarity pathway involved in outflow tract morphogenesis(GO:0061347) planar cell polarity pathway involved in ventricular septum morphogenesis(GO:0061348) planar cell polarity pathway involved in cardiac right atrium morphogenesis(GO:0061349) planar cell polarity pathway involved in cardiac muscle tissue morphogenesis(GO:0061350) planar cell polarity pathway involved in pericardium morphogenesis(GO:0061354) |
| 0.6 | 5.0 | GO:0042760 | very long-chain fatty acid catabolic process(GO:0042760) |
| 0.3 | 1.6 | GO:0018125 | peptidyl-cysteine methylation(GO:0018125) |
| 0.3 | 3.1 | GO:2001269 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269) |
| 0.2 | 6.0 | GO:0021860 | pyramidal neuron development(GO:0021860) |
| 0.2 | 1.3 | GO:0044838 | cell quiescence(GO:0044838) |
| 0.2 | 0.7 | GO:1903288 | positive regulation of potassium ion import(GO:1903288) |
| 0.2 | 0.6 | GO:0072236 | DCT cell differentiation(GO:0072069) metanephric loop of Henle development(GO:0072236) metanephric DCT cell differentiation(GO:0072240) |
| 0.1 | 5.2 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.1 | 0.6 | GO:0030205 | dermatan sulfate metabolic process(GO:0030205) |
| 0.1 | 0.3 | GO:0032240 | RNA import into nucleus(GO:0006404) mRNA export from nucleus in response to heat stress(GO:0031990) negative regulation of nucleobase-containing compound transport(GO:0032240) negative regulation of RNA export from nucleus(GO:0046832) |
| 0.1 | 0.8 | GO:0035331 | negative regulation of hippo signaling(GO:0035331) |
| 0.1 | 1.2 | GO:0010650 | positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
| 0.1 | 1.0 | GO:0018230 | peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231) |
| 0.1 | 0.2 | GO:0002182 | cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248) |
| 0.1 | 0.5 | GO:0050908 | detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962) |
| 0.1 | 0.8 | GO:0031272 | regulation of pseudopodium assembly(GO:0031272) |
| 0.1 | 0.8 | GO:0070914 | UV-damage excision repair(GO:0070914) |
| 0.0 | 0.3 | GO:2000766 | negative regulation of cytoplasmic translation(GO:2000766) |
| 0.0 | 0.4 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
| 0.0 | 0.6 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.0 | 0.2 | GO:0043416 | regulation of skeletal muscle tissue regeneration(GO:0043416) |
| 0.0 | 0.3 | GO:2000671 | regulation of motor neuron apoptotic process(GO:2000671) |
| 0.0 | 0.1 | GO:0090494 | positive regulation of sphingolipid biosynthetic process(GO:0090154) catecholamine uptake(GO:0090493) dopamine uptake(GO:0090494) positive regulation of ceramide biosynthetic process(GO:2000304) |
| 0.0 | 3.6 | GO:0007050 | cell cycle arrest(GO:0007050) |
| 0.0 | 1.8 | GO:0021766 | hippocampus development(GO:0021766) |
| 0.0 | 0.1 | GO:0042822 | pyridoxal phosphate metabolic process(GO:0042822) |
| 0.0 | 0.4 | GO:0097352 | autophagosome maturation(GO:0097352) |
| 0.0 | 1.7 | GO:1900006 | positive regulation of dendrite development(GO:1900006) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 6.0 | GO:0097441 | basilar dendrite(GO:0097441) |
| 0.1 | 1.7 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.1 | 0.7 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.1 | 1.6 | GO:0042588 | zymogen granule(GO:0042588) |
| 0.1 | 3.0 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
| 0.1 | 5.0 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.1 | 1.2 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
| 0.1 | 0.3 | GO:0044615 | nuclear pore nuclear basket(GO:0044615) |
| 0.0 | 0.8 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.0 | 1.2 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.0 | 1.8 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.0 | 5.4 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.0 | 0.5 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.0 | 3.9 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.0 | 1.3 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.0 | 0.4 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.0 | 0.1 | GO:0000137 | Golgi cis cisterna(GO:0000137) |
| 0.0 | 0.5 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.0 | 0.2 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) |
| 0.0 | 1.2 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 1.9 | GO:0005110 | frizzled-2 binding(GO:0005110) |
| 0.4 | 1.3 | GO:0098770 | FBXO family protein binding(GO:0098770) |
| 0.3 | 6.0 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.2 | 3.0 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.1 | 5.4 | GO:0070888 | E-box binding(GO:0070888) |
| 0.1 | 4.4 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.1 | 0.7 | GO:0008556 | sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556) |
| 0.1 | 1.6 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.1 | 0.3 | GO:0004441 | inositol-1,4-bisphosphate 1-phosphatase activity(GO:0004441) |
| 0.1 | 0.3 | GO:0008545 | JUN kinase kinase activity(GO:0008545) |
| 0.1 | 1.9 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.0 | 0.5 | GO:0005314 | high-affinity glutamate transmembrane transporter activity(GO:0005314) |
| 0.0 | 4.5 | GO:0042626 | ATPase activity, coupled to transmembrane movement of substances(GO:0042626) |
| 0.0 | 0.5 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 0.0 | 1.0 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.0 | 0.2 | GO:0035381 | extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) |
| 0.0 | 0.6 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.0 | 0.6 | GO:0016857 | racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857) |
| 0.0 | 5.2 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 0.3 | GO:0000900 | translation repressor activity, nucleic acid binding(GO:0000900) |
| 0.0 | 0.2 | GO:0030550 | acetylcholine receptor inhibitor activity(GO:0030550) |
| 0.0 | 1.8 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 0.1 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 0.0 | 0.1 | GO:0033883 | pyridoxal phosphatase activity(GO:0033883) |
| 0.0 | 2.5 | GO:0001047 | core promoter binding(GO:0001047) |
| 0.0 | 0.1 | GO:0004315 | 3-oxoacyl-[acyl-carrier-protein] synthase activity(GO:0004315) |
| 0.0 | 0.3 | GO:0070840 | dynein complex binding(GO:0070840) |
| 0.0 | 0.3 | GO:0030507 | spectrin binding(GO:0030507) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.9 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
| 0.0 | 1.2 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
| 0.0 | 1.3 | PID_IL2_STAT5_PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.0 | 0.3 | PID_ANTHRAX_PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 0.7 | PID_ERBB1_INTERNALIZATION_PATHWAY | Internalization of ErbB1 |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 5.0 | REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.2 | 4.3 | REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.1 | 3.0 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 1.0 | REACTOME_ENOS_ACTIVATION_AND_REGULATION | Genes involved in eNOS activation and regulation |
| 0.0 | 1.2 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 1.3 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
| 0.0 | 0.7 | REACTOME_BASIGIN_INTERACTIONS | Genes involved in Basigin interactions |
| 0.0 | 0.8 | REACTOME_SIGNALING_BY_HIPPO | Genes involved in Signaling by Hippo |
| 0.0 | 1.9 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 0.7 | REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.0 | 0.3 | REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 | Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| 0.0 | 0.5 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 0.3 | REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
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