Motif ID: Barhl1

Z-value: 0.539


Transcription factors associated with Barhl1:

Gene SymbolEntrez IDGene Name
Barhl1 ENSMUSG00000026805.8 Barhl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Barhl1mm10_v2_chr2_-_28916668_28916668-0.076.3e-01Click!


Activity profile for motif Barhl1.

activity profile for motif Barhl1


Sorted Z-values histogram for motif Barhl1

Sorted Z-values for motif Barhl1



Network of associatons between targets according to the STRING database.



First level regulatory network of Barhl1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_43869993 3.122 ENSMUST00000067469.4
 Tmem74
transmembrane protein 74
chr16_+_92292380 2.297 ENSMUST00000047383.3
 Kcne2
potassium voltage-gated channel, Isk-related subfamily, gene 2
chr16_+_10827921 2.173 ENSMUST00000181732.1
 Gm26822
predicted gene, 26822
chr3_-_146770603 1.980 ENSMUST00000106138.1
 Prkacb
protein kinase, cAMP dependent, catalytic, beta
chr15_-_53902472 1.942 ENSMUST00000078673.6
 Samd12
sterile alpha motif domain containing 12
chr3_-_146770218 1.801 ENSMUST00000106137.1
 Prkacb
protein kinase, cAMP dependent, catalytic, beta
chr18_+_37355271 1.728 ENSMUST00000051163.1
 Pcdhb8
protocadherin beta 8
chr1_+_115684727 1.705 ENSMUST00000043725.7
 Cntnap5a
contactin associated protein-like 5A
chr5_-_62766153 1.487 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr6_-_41636389 1.417 ENSMUST00000031902.5
 Trpv6
transient receptor potential cation channel, subfamily V, member 6
chr2_-_45110336 1.335 ENSMUST00000028229.6
ENSMUST00000152232.1
 Zeb2

zinc finger E-box binding homeobox 2

chr3_+_116008220 1.098 ENSMUST00000106502.1
 Extl2
exostoses (multiple)-like 2
chr16_-_32868325 1.095 ENSMUST00000089684.3
ENSMUST00000040986.8
ENSMUST00000115105.2
 1700021K19Rik


RIKEN cDNA 1700021K19 gene


chr6_-_59426279 1.055 ENSMUST00000051065.4
 Gprin3
GPRIN family member 3
chr11_+_22971991 1.040 ENSMUST00000049506.5
 Zrsr1
zinc finger (CCCH type), RNA binding motif and serine/arginine rich 1
chr6_+_72097561 1.035 ENSMUST00000069994.4
ENSMUST00000114112.1
 St3gal5

ST3 beta-galactoside alpha-2,3-sialyltransferase 5

chr17_-_78418083 1.031 ENSMUST00000070039.7
ENSMUST00000112487.1
 Fez2

fasciculation and elongation protein zeta 2 (zygin II)

chr11_+_102430315 0.959 ENSMUST00000049460.4
ENSMUST00000129997.1
 Grn

granulin

chr15_+_55112317 0.951 ENSMUST00000096433.3
 Deptor
DEP domain containing MTOR-interacting protein
chr7_+_45896941 0.931 ENSMUST00000069772.7
ENSMUST00000107716.1
 Tmem143

transmembrane protein 143

chr3_+_75557530 0.928 ENSMUST00000161776.1
ENSMUST00000029423.8
 Serpini1

serine (or cysteine) peptidase inhibitor, clade I, member 1

chr2_+_83812567 0.895 ENSMUST00000051454.3
 Fam171b
family with sequence similarity 171, member B
chr1_-_75278345 0.878 ENSMUST00000039534.4
 Resp18
regulated endocrine-specific protein 18
chrX_+_112604274 0.874 ENSMUST00000071814.6
 Zfp711
zinc finger protein 711
chr13_+_63014934 0.671 ENSMUST00000091560.4
 2010111I01Rik
RIKEN cDNA 2010111I01 gene
chr10_-_41303171 0.636 ENSMUST00000043814.3
 Fig4
FIG4 homolog (S. cerevisiae)
chr17_+_55892184 0.634 ENSMUST00000054780.8
 Zfp959
zinc finger protein 959
chr17_-_25115905 0.620 ENSMUST00000024987.5
ENSMUST00000115181.2
 Telo2

TEL2, telomere maintenance 2, homolog (S. cerevisiae)

chr10_+_102158858 0.580 ENSMUST00000138522.1
ENSMUST00000163753.1
ENSMUST00000138016.1
 Mgat4c


mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)


chr7_+_45897429 0.566 ENSMUST00000140243.1
 Tmem143
transmembrane protein 143
chr7_+_12834743 0.563 ENSMUST00000004614.8
 Zfp110
zinc finger protein 110
chr18_+_12972225 0.540 ENSMUST00000025290.5
 Impact
imprinted and ancient
chr8_+_40307458 0.524 ENSMUST00000068999.7
 Micu3
mitochondrial calcium uptake family, member 3
chr7_+_97842917 0.483 ENSMUST00000033040.5
 Pak1
p21 protein (Cdc42/Rac)-activated kinase 1
chr2_-_80128834 0.472 ENSMUST00000102654.4
ENSMUST00000102655.3
 Pde1a

phosphodiesterase 1A, calmodulin-dependent

chr16_+_33251415 0.406 ENSMUST00000023502.4
 Snx4
sorting nexin 4
chr11_+_116198853 0.369 ENSMUST00000021130.6
 Ten1
TEN1 telomerase capping complex subunit
chr5_-_24581879 0.318 ENSMUST00000088299.4
 Gm10221
predicted gene 10221
chr6_+_125349699 0.301 ENSMUST00000032491.8
 Tnfrsf1a
tumor necrosis factor receptor superfamily, member 1a
chr5_-_62765618 0.289 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr13_+_63015167 0.274 ENSMUST00000021911.8
 2010111I01Rik
RIKEN cDNA 2010111I01 gene
chr18_+_56562443 0.260 ENSMUST00000130163.1
ENSMUST00000132628.1
 Phax

phosphorylated adaptor for RNA export

chrX_-_75578188 0.242 ENSMUST00000033545.5
 Rab39b
RAB39B, member RAS oncogene family
chr3_-_130709419 0.239 ENSMUST00000043937.7
 Ostc
oligosaccharyltransferase complex subunit
chr11_+_78826575 0.211 ENSMUST00000147875.2
ENSMUST00000141321.1
 Lyrm9

LYR motif containing 9

chr2_-_151632471 0.110 ENSMUST00000137936.1
ENSMUST00000146172.1
ENSMUST00000094456.3
ENSMUST00000148755.1
ENSMUST00000109875.1
ENSMUST00000028951.7
ENSMUST00000109877.3
 Snph






syntaphilin






chr16_-_91618986 0.058 ENSMUST00000143058.1
ENSMUST00000049244.8
ENSMUST00000169982.1
ENSMUST00000133731.1
 Dnajc28



DnaJ (Hsp40) homolog, subfamily C, member 28



chr5_+_149678224 0.058 ENSMUST00000100404.3
 B3galtl
beta 1,3-galactosyltransferase-like
chr2_+_122426432 0.026 ENSMUST00000110525.1
 Slc28a2
solute carrier family 28 (sodium-coupled nucleoside transporter), member 2
chr9_+_36832684 0.025 ENSMUST00000034630.8
 Fez1
fasciculation and elongation protein zeta 1 (zygin I)
chr8_+_31089471 0.017 ENSMUST00000036631.7
ENSMUST00000170204.1
 Dusp26

dual specificity phosphatase 26 (putative)

chr10_-_5069044 0.008 ENSMUST00000095899.3
 Syne1
spectrin repeat containing, nuclear envelope 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.3 GO:1901979 regulation of inward rectifier potassium channel activity(GO:1901979)
0.3 3.8 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.3 1.1 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.2 1.3 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.2 1.4 GO:0098703 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.2 0.5 GO:0032058 positive regulation of translational initiation in response to stress(GO:0032058)
0.2 0.5 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.1 1.0 GO:0035188 blastocyst hatching(GO:0001835) hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
0.1 0.3 GO:0051030 snRNA transport(GO:0051030)
0.1 1.1 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)
0.1 0.6 GO:1990009 retinal cell apoptotic process(GO:1990009)
0.1 0.6 GO:0031642 negative regulation of myelination(GO:0031642)
0.1 0.6 GO:0038203 TORC2 signaling(GO:0038203)
0.1 0.4 GO:0002553 histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553)
0.1 1.0 GO:0045792 negative regulation of cell size(GO:0045792)
0.0 0.9 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.5 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 1.0 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 0.2 GO:1901550 regulation of endothelial cell development(GO:1901550) regulation of establishment of endothelial barrier(GO:1903140)
0.0 3.1 GO:0016236 macroautophagy(GO:0016236)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.8 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.2 0.9 GO:0031983 vesicle lumen(GO:0031983)
0.2 0.9 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.1 1.0 GO:0089701 U2AF(GO:0089701)
0.1 0.6 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.5 GO:0071437 invadopodium(GO:0071437)
0.0 0.4 GO:0000783 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.0 2.3 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.4 GO:0005868 cytoplasmic dynein complex(GO:0005868)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.3 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.4 3.8 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.4 1.1 GO:0001888 glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0001888)
0.1 0.6 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.1 0.6 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1 0.6 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.1 0.4 GO:1990460 leptin receptor binding(GO:1990460)
0.1 0.3 GO:0043120 tumor necrosis factor binding(GO:0043120)
0.1 1.7 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.1 1.0 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.1 0.5 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 0.9 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 1.0 GO:0008373 sialyltransferase activity(GO:0008373)
0.0 1.8 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 1.3 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.3 GO:0015643 toxic substance binding(GO:0015643)
0.0 1.4 GO:0005262 calcium channel activity(GO:0005262)
0.0 0.6 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 0.2 GO:0031489 myosin V binding(GO:0031489)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.8 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 1.8 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.5 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 1.4 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B
0.0 0.3 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 1.0 PID_MET_PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.8 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.6 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.5 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.6 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.5 REACTOME_CA_DEPENDENT_EVENTS Genes involved in Ca-dependent events
0.0 0.3 REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 1.8 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases