ISMARA results: Barhl2

Motif ID: Barhl2

Z-value: 0.674

Transcription factors associated with Barhl2:

Gene Symbol	Entrez ID	Gene Name
Barhl2	ENSMUSG00000034384.10	Barhl2

Activity-expression correlation:

Gene Symbol	Promoter	Pearson corr. coef.	P-value	Plot
Barhl2	mm10_v2_chr5_-_106458440_106458470	-0.30	2.7e-02	Click!

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr11_+_112782182	6.415	ENSMUST00000000579.2	Sox9	SRY-box containing gene 9
chr4_+_154960915	6.205	ENSMUST00000049621.6	Hes5	hairy and enhancer of split 5 (Drosophila)
chr18_-_80986578	5.177	ENSMUST00000057950.7	Sall3	sal-like 3 (Drosophila)
chr5_+_110839973	5.156	ENSMUST00000066160.1	Chek2	checkpoint kinase 2
chr18_-_78206408	5.071	ENSMUST00000163367.1	Slc14a2	solute carrier family 14 (urea transporter), member 2
chrX_-_60893430	4.939	ENSMUST00000135107.2	Sox3	SRY-box containing gene 3
chr3_-_27153844	4.008	ENSMUST00000176242.2 ENSMUST00000176780.1	Ect2	ect2 oncogene
chr3_-_27153861	3.926	ENSMUST00000108300.1 ENSMUST00000108298.2	Ect2	ect2 oncogene
chr16_-_22439719	3.893	ENSMUST00000079601.6	Etv5	ets variant gene 5
chr2_+_59612034	3.825	ENSMUST00000112568.1 ENSMUST00000037526.4	Tanc1	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
chr3_-_27153782	3.699	ENSMUST00000175857.1 ENSMUST00000177055.1 ENSMUST00000176535.1	Ect2	ect2 oncogene
chr2_+_163225363	3.400	ENSMUST00000099110.3 ENSMUST00000165937.1	Tox2	TOX high mobility group box family member 2
chr2_+_118814237	3.155	ENSMUST00000028803.7 ENSMUST00000126045.1	Knstrn	kinetochore-localized astrin/SPAG5 binding
chr17_-_49564262	3.137	ENSMUST00000057610.6	Daam2	dishevelled associated activator of morphogenesis 2
chr4_-_58553553	2.991	ENSMUST00000107575.2 ENSMUST00000107574.1 ENSMUST00000147354.1	Lpar1	lysophosphatidic acid receptor 1
chr2_+_31640037	2.923	ENSMUST00000113470.2	Prdm12	PR domain containing 12
chr15_+_99074968	2.599	ENSMUST00000039665.6	Troap	trophinin associated protein
chr17_-_25727364	2.588	ENSMUST00000170070.1 ENSMUST00000048054.7	Chtf18	CTF18, chromosome transmission fidelity factor 18
chr8_+_57511833	2.480	ENSMUST00000067925.6	Hmgb2	high mobility group box 2
chr2_-_127133909	2.395	ENSMUST00000110387.3	Ncaph	non-SMC condensin I complex, subunit H
chr7_+_79660196	2.146	ENSMUST00000035977.7	Ticrr	TOPBP1-interacting checkpoint and replication regulator
chr5_+_33658123	2.143	ENSMUST00000074849.6 ENSMUST00000079534.4	Tacc3	transforming, acidic coiled-coil containing protein 3
chr7_+_127841752	2.137	ENSMUST00000033075.7	Stx4a	syntaxin 4A (placental)
chr3_-_154328634	2.088	ENSMUST00000167744.1	Lhx8	LIM homeobox protein 8
chr18_+_61045139	2.007	ENSMUST00000025522.4 ENSMUST00000115274.1	Pdgfrb	platelet derived growth factor receptor, beta polypeptide
chr7_+_127841817	1.972	ENSMUST00000121705.1	Stx4a	syntaxin 4A (placental)
chr19_-_6969746	1.891	ENSMUST00000025912.8	Plcb3	phospholipase C, beta 3
chr12_-_34528844	1.889	ENSMUST00000110819.2	Hdac9	histone deacetylase 9
chr12_+_78748947	1.869	ENSMUST00000082024.5	Mpp5	membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
chr6_-_95718800	1.824	ENSMUST00000079847.5	Suclg2	succinate-Coenzyme A ligase, GDP-forming, beta subunit
chr2_-_58052832	1.781	ENSMUST00000090940.5	Ermn	ermin, ERM-like protein
chr4_+_132768325	1.771	ENSMUST00000102561.4	Rpa2	replication protein A2
chr15_-_33405976	1.751	ENSMUST00000079057.6	1700084J12Rik	RIKEN cDNA 1700084J12 gene
chr13_-_47106176	1.703	ENSMUST00000021807.6 ENSMUST00000135278.1	Dek	DEK oncogene (DNA binding)
chr16_-_22439570	1.667	ENSMUST00000170393.1	Etv5	ets variant gene 5
chr1_+_165788681	1.270	ENSMUST00000161971.1 ENSMUST00000178336.1 ENSMUST00000005907.5 ENSMUST00000027849.4	Cd247	CD247 antigen
chr10_+_58394381	1.239	ENSMUST00000105468.1	Lims1	LIM and senescent cell antigen-like domains 1
chr16_+_10835046	1.195	ENSMUST00000037913.8	Rmi2	RMI2, RecQ mediated genome instability 2, homolog (S. cerevisiae)
chr6_-_101377897	1.086	ENSMUST00000075994.6	Pdzrn3	PDZ domain containing RING finger 3
chr5_+_65131184	1.084	ENSMUST00000031089.5 ENSMUST00000101191.3	Klhl5	kelch-like 5
chr5_-_110839575	1.024	ENSMUST00000145318.1	Hscb	HscB iron-sulfur cluster co-chaperone homolog (E. coli)
chr18_-_84086379	0.964	ENSMUST00000060303.8	Tshz1	teashirt zinc finger family member 1
chr1_-_93343482	0.956	ENSMUST00000128253.1	Pask	PAS domain containing serine/threonine kinase
chr7_+_127211608	0.935	ENSMUST00000032910.6	Mylpf	myosin light chain, phosphorylatable, fast skeletal muscle
chr3_-_49757257	0.921	ENSMUST00000035931.7	Pcdh18	protocadherin 18
chr9_-_13826946	0.919	ENSMUST00000147115.1	Cep57	centrosomal protein 57
chr8_+_94214567	0.915	ENSMUST00000079961.6	Nup93	nucleoporin 93
chr1_+_165788746	0.915	ENSMUST00000161559.2	Cd247	CD247 antigen
chrX_+_82948861	0.880	ENSMUST00000114000.1	Dmd	dystrophin, muscular dystrophy
chr1_-_163725123	0.854	ENSMUST00000159679.1	Mettl11b	methyltransferase like 11B
chr5_-_110839757	0.835	ENSMUST00000056937.5	Hscb	HscB iron-sulfur cluster co-chaperone homolog (E. coli)
chr2_+_181319714	0.830	ENSMUST00000098971.4 ENSMUST00000054622.8 ENSMUST00000108814.1 ENSMUST00000048608.9 ENSMUST00000108815.1	Rtel1	regulator of telomere elongation helicase 1
chr7_+_27486910	0.809	ENSMUST00000008528.7	Sertad1	SERTA domain containing 1
chr17_+_35439155	0.803	ENSMUST00000071951.6 ENSMUST00000078205.7 ENSMUST00000116598.3 ENSMUST00000076256.7	H2-Q7	histocompatibility 2, Q region locus 7
chr10_+_58394361	0.766	ENSMUST00000020077.4	Lims1	LIM and senescent cell antigen-like domains 1
chr5_-_37824580	0.762	ENSMUST00000063116.9	Msx1	msh homeobox 1
chr17_+_35220834	0.756	ENSMUST00000118793.1	Gm16181	predicted gene 16181
chr6_-_8259098	0.703	ENSMUST00000012627.4	Rpa3	replication protein A3
chr7_+_43444104	0.676	ENSMUST00000004729.3	Etfb	electron transferring flavoprotein, beta polypeptide
chr6_-_34317442	0.663	ENSMUST00000154655.1 ENSMUST00000102980.4	Akr1b3	aldo-keto reductase family 1, member B3 (aldose reductase)
chr11_+_78261717	0.591	ENSMUST00000010421.6	2610507B11Rik	RIKEN cDNA 2610507B11 gene
chr7_+_24370255	0.581	ENSMUST00000171904.1	Kcnn4	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr10_+_80826656	0.527	ENSMUST00000060987.8 ENSMUST00000177850.1 ENSMUST00000180036.1 ENSMUST00000179172.1	Oaz1	ornithine decarboxylase antizyme 1
chr7_+_3629985	0.482	ENSMUST00000008517.6 ENSMUST00000179769.1	Prpf31	PRP31 pre-mRNA processing factor 31 homolog (yeast)
chr18_+_34736359	0.473	ENSMUST00000105038.2	Gm3550	predicted gene 3550
chr10_-_128626464	0.472	ENSMUST00000026420.5	Rps26	ribosomal protein S26
chr2_+_181319806	0.452	ENSMUST00000153112.1	Rtel1	regulator of telomere elongation helicase 1
chr8_-_107439585	0.447	ENSMUST00000077208.4	Rps26-ps1	ribosomal protein S26, pseudogene 1
chr7_+_101969796	0.439	ENSMUST00000084852.5	Numa1	nuclear mitotic apparatus protein 1
chr5_+_135168382	0.416	ENSMUST00000111187.3 ENSMUST00000111188.1	Bcl7b	B cell CLL/lymphoma 7B
chr11_+_85832551	0.374	ENSMUST00000000095.6	Tbx2	T-box 2
chr1_-_171287931	0.331	ENSMUST00000111306.3 ENSMUST00000065941.5	Usp21	ubiquitin specific peptidase 21
chr14_+_21500879	0.326	ENSMUST00000182964.1	Kat6b	K(lysine) acetyltransferase 6B
chr1_+_105990652	0.324	ENSMUST00000118196.1	Zcchc2	zinc finger, CCHC domain containing 2
chr18_+_4993795	0.320	ENSMUST00000153016.1	Svil	supervillin
chr1_+_91250482	0.312	ENSMUST00000171112.1	Ube2f	ubiquitin-conjugating enzyme E2F (putative)
chr19_-_29648355	0.301	ENSMUST00000159692.1	Ermp1	endoplasmic reticulum metallopeptidase 1
chr10_-_99759658	0.262	ENSMUST00000056085.4	Csl	citrate synthase like
chr19_-_12796108	0.227	ENSMUST00000038627.8	Zfp91	zinc finger protein 91
chrX_+_71663665	0.225	ENSMUST00000070449.5	Gpr50	G-protein-coupled receptor 50
chr2_-_18048347	0.223	ENSMUST00000066885.5	Skida1	SKI/DACH domain containing 1
chr4_-_9643638	0.214	ENSMUST00000108333.1 ENSMUST00000108334.1 ENSMUST00000108335.1 ENSMUST00000152526.1 ENSMUST00000103004.3	Asph	aspartate-beta-hydroxylase
chr1_-_171287916	0.209	ENSMUST00000111305.1	Usp21	ubiquitin specific peptidase 21
chr9_-_13827029	0.197	ENSMUST00000148086.1 ENSMUST00000034398.5	Cep57	centrosomal protein 57
chr14_+_30825580	0.196	ENSMUST00000006701.5	Tmem110	transmembrane protein 110
chr5_+_135168283	0.190	ENSMUST00000031692.5	Bcl7b	B cell CLL/lymphoma 7B
chr5_-_134946917	0.168	ENSMUST00000051401.2	Cldn4	claudin 4
chr1_+_105990384	0.148	ENSMUST00000119166.1	Zcchc2	zinc finger, CCHC domain containing 2
chr17_+_27839974	0.128	ENSMUST00000071006.7	Snrpc	U1 small nuclear ribonucleoprotein C
chr3_+_96629919	0.116	ENSMUST00000048915.6	Rbm8a	RNA binding motif protein 8a
chr17_-_26939464	0.114	ENSMUST00000025027.8 ENSMUST00000114935.1	Cuta	cutA divalent cation tolerance homolog (E. coli)
chr1_+_91250311	0.081	ENSMUST00000059743.5 ENSMUST00000178627.1 ENSMUST00000171165.1	Ube2f	ubiquitin-conjugating enzyme E2F (putative)
chr6_-_146502099	0.065	ENSMUST00000053273.8	Itpr2	inositol 1,4,5-triphosphate receptor 2
chr10_+_88459569	0.054	ENSMUST00000020252.3 ENSMUST00000125612.1	Sycp3	synaptonemal complex protein 3
chr18_+_42511496	0.048	ENSMUST00000025375.7	Tcerg1	transcription elongation regulator 1 (CA150)
chr9_+_61372359	0.018	ENSMUST00000178113.1 ENSMUST00000159386.1	Tle3	transducin-like enhancer of split 3, homolog of Drosophila E(spl)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
2.1	6.4	GO:0035622	intrahepatic bile duct development(GO:0035622) renal vesicle induction(GO:0072034)
1.7	5.1	GO:0071918	urea transmembrane transport(GO:0071918)
1.6	6.2	GO:2000974	negative regulation of pro-B cell differentiation(GO:2000974)
1.4	4.1	GO:0002447	eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) eosinophil degranulation(GO:0043308) regulation of eosinophil activation(GO:1902566)
1.3	5.2	GO:1903463	regulation of mitotic cell cycle DNA replication(GO:1903463)
1.1	5.6	GO:0048133	germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.8	14.8	GO:0051988	regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.8	2.4	GO:2000373	regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
0.7	3.0	GO:1904565	response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.7	2.0	GO:0035441	cell migration involved in vasculogenesis(GO:0035441)
0.6	2.9	GO:1900109	regulation of histone H3-K9 dimethylation(GO:1900109)
0.5	1.9	GO:0031161	phosphatidylinositol catabolic process(GO:0031161)
0.4	2.0	GO:2000346	negative regulation of hepatocyte proliferation(GO:2000346)
0.4	5.2	GO:0021891	olfactory bulb interneuron development(GO:0021891)
0.4	2.5	GO:0045654	positive regulation of megakaryocyte differentiation(GO:0045654)
0.3	1.7	GO:2001032	regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.3	1.0	GO:0060023	soft palate development(GO:0060023)
0.3	1.3	GO:1902990	mitotic telomere maintenance via semi-conservative replication(GO:1902990) negative regulation of t-circle formation(GO:1904430)
0.3	0.9	GO:0014809	regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.3	2.6	GO:1900262	regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.3	2.1	GO:0030174	regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.3	1.9	GO:0097428	protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.3	4.9	GO:0007530	sex determination(GO:0007530)
0.3	0.8	GO:0035880	embryonic nail plate morphogenesis(GO:0035880)
0.2	0.7	GO:0006059	hexitol metabolic process(GO:0006059) alditol biosynthetic process(GO:0019401)
0.2	1.9	GO:0034983	peptidyl-lysine deacetylation(GO:0034983)
0.2	1.8	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.2	0.9	GO:0090521	glomerular visceral epithelial cell migration(GO:0090521)
0.2	2.6	GO:0030953	astral microtubule organization(GO:0030953)
0.1	3.8	GO:0097062	dendritic spine maintenance(GO:0097062)
0.1	0.5	GO:1902268	negative regulation of polyamine transmembrane transport(GO:1902268)
0.1	0.4	GO:0007521	muscle cell fate determination(GO:0007521) mammary placode formation(GO:0060596)
0.1	1.9	GO:0032287	peripheral nervous system myelin maintenance(GO:0032287)
0.1	1.0	GO:0070874	negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.1	2.5	GO:0006298	mismatch repair(GO:0006298)
0.1	2.2	GO:0070207	protein homotrimerization(GO:0070207)
0.1	0.2	GO:0042264	peptidyl-aspartic acid hydroxylation(GO:0042264)
0.1	0.6	GO:0071435	stabilization of membrane potential(GO:0030322) positive regulation of T cell receptor signaling pathway(GO:0050862) potassium ion export(GO:0071435)
0.0	2.1	GO:0021884	forebrain neuron development(GO:0021884)
0.0	1.1	GO:0034453	microtubule anchoring(GO:0034453)
0.0	0.9	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0	0.5	GO:0000244	spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0	0.7	GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0	0.8	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.0	0.5	GO:0016578	histone deubiquitination(GO:0016578)
0.0	1.1	GO:0007528	neuromuscular junction development(GO:0007528)
0.0	2.1	GO:0007368	determination of left/right symmetry(GO:0007368)
0.0	0.4	GO:0045116	protein neddylation(GO:0045116)
0.0	0.2	GO:0007250	activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0	0.1	GO:0000395	mRNA 5'-splice site recognition(GO:0000395)
0.0	0.1	GO:0051309	female meiosis chromosome separation(GO:0051309)
0.0	0.2	GO:0061436	establishment of skin barrier(GO:0061436)
0.0	0.5	GO:0033119	negative regulation of RNA splicing(GO:0033119)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
2.3	11.6	GO:0097149	centralspindlin complex(GO:0097149)
0.8	2.4	GO:0000799	nuclear condensin complex(GO:0000799)
0.7	6.0	GO:0035749	myelin sheath adaxonal region(GO:0035749)
0.5	2.2	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.4	2.1	GO:0001674	female germ cell nucleus(GO:0001674)
0.3	1.8	GO:0030062	mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.3	2.6	GO:0031390	Ctf18 RFC-like complex(GO:0031390)
0.2	1.8	GO:0033269	internode region of axon(GO:0033269)
0.2	0.7	GO:0045251	mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.2	0.7	GO:0097454	Schwann cell microvillus(GO:0097454)
0.2	2.5	GO:0005662	DNA replication factor A complex(GO:0005662)
0.1	0.4	GO:0030981	cortical microtubule cytoskeleton(GO:0030981)
0.1	3.2	GO:0035371	microtubule plus-end(GO:0035371)
0.1	0.8	GO:0042612	MHC class I protein complex(GO:0042612)
0.1	0.9	GO:0016010	dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0	0.5	GO:0005687	U4 snRNP(GO:0005687)
0.0	3.7	GO:0016605	PML body(GO:0016605)
0.0	1.3	GO:0000781	chromosome, telomeric region(GO:0000781)
0.0	5.4	GO:0044798	nuclear transcription factor complex(GO:0044798)
0.0	1.9	GO:0035097	histone methyltransferase complex(GO:0035097)
0.0	2.6	GO:0043198	dendritic shaft(GO:0043198)
0.0	0.2	GO:0032541	cortical endoplasmic reticulum(GO:0032541)
0.0	2.5	GO:0000793	condensed chromosome(GO:0000793)
0.0	0.3	GO:0043034	costamere(GO:0043034)
0.0	0.1	GO:0000243	commitment complex(GO:0000243)
0.0	1.9	GO:0042383	sarcolemma(GO:0042383)
0.0	1.1	GO:0031594	neuromuscular junction(GO:0031594)
0.0	2.8	GO:0045211	postsynaptic membrane(GO:0045211)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.0	4.1	GO:0016230	sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.8	5.1	GO:0015204	urea transmembrane transporter activity(GO:0015204)
0.6	1.8	GO:0004774	succinate-CoA ligase activity(GO:0004774)
0.5	5.8	GO:0097157	pre-mRNA intronic binding(GO:0097157)
0.4	3.0	GO:0035727	lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.4	2.5	GO:0050786	RAGE receptor binding(GO:0050786)
0.4	2.0	GO:0038085	vascular endothelial growth factor binding(GO:0038085)
0.4	2.4	GO:0044547	DNA topoisomerase binding(GO:0044547)
0.2	2.6	GO:0003689	DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.2	2.9	GO:1990226	histone methyltransferase binding(GO:1990226)
0.2	1.8	GO:0098505	G-rich strand telomeric DNA binding(GO:0098505)
0.1	0.6	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
0.1	5.0	GO:0001106	RNA polymerase II transcription corepressor activity(GO:0001106)
0.1	0.7	GO:0004032	alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.1	0.5	GO:0008073	ornithine decarboxylase inhibitor activity(GO:0008073)
0.1	14.8	GO:0017048	Rho GTPase binding(GO:0017048)
0.1	1.9	GO:0004435	phosphatidylinositol phospholipase C activity(GO:0004435)
0.1	0.5	GO:0030621	U4 snRNA binding(GO:0030621)
0.1	0.5	GO:0019784	NEDD8-specific protease activity(GO:0019784)
0.1	1.9	GO:0031078	histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1	1.9	GO:0004385	guanylate kinase activity(GO:0004385)
0.1	0.2	GO:0008502	melatonin receptor activity(GO:0008502)
0.1	0.9	GO:0002162	dystroglycan binding(GO:0002162)
0.1	0.8	GO:0030881	beta-2-microglobulin binding(GO:0030881)
0.1	1.3	GO:0070182	DNA polymerase binding(GO:0070182)
0.0	0.4	GO:0019788	NEDD8 transferase activity(GO:0019788)
0.0	0.4	GO:0051011	microtubule minus-end binding(GO:0051011)
0.0	0.9	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.0	7.5	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0	1.1	GO:0017134	fibroblast growth factor binding(GO:0017134)
0.0	2.2	GO:1990782	protein tyrosine kinase binding(GO:1990782)
0.0	0.9	GO:0008307	structural constituent of muscle(GO:0008307)
0.0	3.4	GO:0001085	RNA polymerase II transcription factor binding(GO:0001085)
0.0	0.1	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.1	GO:1990446	U1 snRNP binding(GO:1990446)
0.0	0.7	GO:0003684	damaged DNA binding(GO:0003684)
0.0	1.2	GO:0051087	chaperone binding(GO:0051087)
0.0	12.9	GO:0043565	sequence-specific DNA binding(GO:0043565)
0.0	0.9	GO:0008276	protein methyltransferase activity(GO:0008276)
0.0	4.6	GO:0031625	ubiquitin protein ligase binding(GO:0031625)
0.0	0.7	GO:0009055	electron carrier activity(GO:0009055)
0.0	3.5	GO:0003682	chromatin binding(GO:0003682)

Gene overrepresentation in C2:CP category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	7.7	PID_IL12_STAT4_PATHWAY	IL12 signaling mediated by STAT4
0.2	10.5	PID_PLK1_PATHWAY	PLK1 signaling events
0.1	5.2	PID_FOXM1_PATHWAY	FOXM1 transcription factor network
0.1	2.7	PID_AURORA_A_PATHWAY	Aurora A signaling
0.1	2.4	PID_AURORA_B_PATHWAY	Aurora B signaling
0.1	1.9	PID_IL8_CXCR1_PATHWAY	IL8- and CXCR1-mediated signaling events
0.1	2.0	PID_UPA_UPAR_PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1	5.9	PID_CDC42_PATHWAY	CDC42 signaling events
0.1	3.0	PID_LYSOPHOSPHOLIPID_PATHWAY	LPA receptor mediated events
0.1	2.0	PID_ILK_PATHWAY	Integrin-linked kinase signaling
0.0	1.8	PID_ATR_PATHWAY	ATR signaling pathway
0.0	1.9	PID_HDAC_CLASSII_PATHWAY	Signaling events mediated by HDAC Class II

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	5.2	REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.4	2.2	REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.3	5.1	REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS	Genes involved in Amine compound SLC transporters
0.2	2.5	REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND	Genes involved in Removal of the Flap Intermediate from the C-strand
0.2	1.9	REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.2	2.5	REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
0.1	11.6	REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK	Genes involved in NRAGE signals death through JNK
0.1	8.1	REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1	2.0	REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.1	1.8	REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.1	2.0	REACTOME_TIGHT_JUNCTION_INTERACTIONS	Genes involved in Tight junction interactions
0.1	0.4	REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES	Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0	1.8	REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT	Genes involved in Mitochondrial Protein Import
0.0	0.9	REACTOME_STRIATED_MUSCLE_CONTRACTION	Genes involved in Striated Muscle Contraction
0.0	0.9	REACTOME_TRANSPORT_OF_RIBONUCLEOPROTEINS_INTO_THE_HOST_NUCLEUS	Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0	2.1	REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS	Genes involved in Class A/1 (Rhodopsin-like receptors)
0.0	0.1	REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.0	0.7	REACTOME_RESPIRATORY_ELECTRON_TRANSPORT	Genes involved in Respiratory electron transport