Motif ID: Barhl2

Z-value: 0.674


Transcription factors associated with Barhl2:

Gene SymbolEntrez IDGene Name
Barhl2 ENSMUSG00000034384.10 Barhl2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Barhl2mm10_v2_chr5_-_106458440_106458470-0.302.7e-02Click!


Activity profile for motif Barhl2.

activity profile for motif Barhl2


Sorted Z-values histogram for motif Barhl2

Sorted Z-values for motif Barhl2



Network of associatons between targets according to the STRING database.



First level regulatory network of Barhl2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 96 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_112782182 6.415 ENSMUST00000000579.2
 Sox9
SRY-box containing gene 9
chr4_+_154960915 6.205 ENSMUST00000049621.6
 Hes5
hairy and enhancer of split 5 (Drosophila)
chr18_-_80986578 5.177 ENSMUST00000057950.7
 Sall3
sal-like 3 (Drosophila)
chr5_+_110839973 5.156 ENSMUST00000066160.1
 Chek2
checkpoint kinase 2
chr18_-_78206408 5.071 ENSMUST00000163367.1
 Slc14a2
solute carrier family 14 (urea transporter), member 2
chrX_-_60893430 4.939 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr3_-_27153844 4.008 ENSMUST00000176242.2
ENSMUST00000176780.1
 Ect2

ect2 oncogene

chr3_-_27153861 3.926 ENSMUST00000108300.1
ENSMUST00000108298.2
 Ect2

ect2 oncogene

chr16_-_22439719 3.893 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr2_+_59612034 3.825 ENSMUST00000112568.1
ENSMUST00000037526.4
 Tanc1

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

chr3_-_27153782 3.699 ENSMUST00000175857.1
ENSMUST00000177055.1
ENSMUST00000176535.1
 Ect2


ect2 oncogene


chr2_+_163225363 3.400 ENSMUST00000099110.3
ENSMUST00000165937.1
 Tox2

TOX high mobility group box family member 2

chr2_+_118814237 3.155 ENSMUST00000028803.7
ENSMUST00000126045.1
 Knstrn

kinetochore-localized astrin/SPAG5 binding

chr17_-_49564262 3.137 ENSMUST00000057610.6
 Daam2
dishevelled associated activator of morphogenesis 2
chr4_-_58553553 2.991 ENSMUST00000107575.2
ENSMUST00000107574.1
ENSMUST00000147354.1
 Lpar1


lysophosphatidic acid receptor 1


chr2_+_31640037 2.923 ENSMUST00000113470.2
 Prdm12
PR domain containing 12
chr15_+_99074968 2.599 ENSMUST00000039665.6
 Troap
trophinin associated protein
chr17_-_25727364 2.588 ENSMUST00000170070.1
ENSMUST00000048054.7
 Chtf18

CTF18, chromosome transmission fidelity factor 18

chr8_+_57511833 2.480 ENSMUST00000067925.6
 Hmgb2
high mobility group box 2
chr2_-_127133909 2.395 ENSMUST00000110387.3
 Ncaph
non-SMC condensin I complex, subunit H

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 14.8 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
2.1 6.4 GO:0035622 intrahepatic bile duct development(GO:0035622) renal vesicle induction(GO:0072034)
1.6 6.2 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
1.1 5.6 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
1.3 5.2 GO:1903463 regulation of mitotic cell cycle DNA replication(GO:1903463)
0.4 5.2 GO:0021891 olfactory bulb interneuron development(GO:0021891)
1.7 5.1 GO:0071918 urea transmembrane transport(GO:0071918)
0.3 4.9 GO:0007530 sex determination(GO:0007530)
1.4 4.1 GO:0002447 eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) eosinophil degranulation(GO:0043308) regulation of eosinophil activation(GO:1902566)
0.1 3.8 GO:0097062 dendritic spine maintenance(GO:0097062)
0.7 3.0 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.6 2.9 GO:1900109 regulation of histone H3-K9 dimethylation(GO:1900109)
0.3 2.6 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.2 2.6 GO:0030953 astral microtubule organization(GO:0030953)
0.4 2.5 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.1 2.5 GO:0006298 mismatch repair(GO:0006298)
0.8 2.4 GO:2000373 regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
0.1 2.2 GO:0070207 protein homotrimerization(GO:0070207)
0.3 2.1 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.0 2.1 GO:0021884 forebrain neuron development(GO:0021884)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 11.6 GO:0097149 centralspindlin complex(GO:0097149)
0.7 6.0 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.0 5.4 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 3.7 GO:0016605 PML body(GO:0016605)
0.1 3.2 GO:0035371 microtubule plus-end(GO:0035371)
0.0 2.8 GO:0045211 postsynaptic membrane(GO:0045211)
0.3 2.6 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.0 2.6 GO:0043198 dendritic shaft(GO:0043198)
0.2 2.5 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 2.5 GO:0000793 condensed chromosome(GO:0000793)
0.8 2.4 GO:0000799 nuclear condensin complex(GO:0000799)
0.5 2.2 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.4 2.1 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 1.9 GO:0035097 histone methyltransferase complex(GO:0035097)
0.0 1.9 GO:0042383 sarcolemma(GO:0042383)
0.3 1.8 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.2 1.8 GO:0033269 internode region of axon(GO:0033269)
0.0 1.3 GO:0000781 chromosome, telomeric region(GO:0000781)
0.0 1.1 GO:0031594 neuromuscular junction(GO:0031594)
0.1 0.9 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 14.8 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 12.9 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.0 7.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.5 5.8 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.8 5.1 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.1 5.0 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 4.6 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
1.0 4.1 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.0 3.5 GO:0003682 chromatin binding(GO:0003682)
0.0 3.4 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.4 3.0 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.2 2.9 GO:1990226 histone methyltransferase binding(GO:1990226)
0.2 2.6 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.4 2.5 GO:0050786 RAGE receptor binding(GO:0050786)
0.4 2.4 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.0 2.2 GO:1990782 protein tyrosine kinase binding(GO:1990782)
0.4 2.0 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.1 1.9 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.1 1.9 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1 1.9 GO:0004385 guanylate kinase activity(GO:0004385)

Gene overrepresentation in C2:CP category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.5 PID_PLK1_PATHWAY PLK1 signaling events
0.2 7.7 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 5.9 PID_CDC42_PATHWAY CDC42 signaling events
0.1 5.2 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 3.0 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.1 2.7 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 2.4 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 2.0 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 2.0 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.1 1.9 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.0 1.9 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 1.8 PID_ATR_PATHWAY ATR signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.6 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 8.1 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.5 5.2 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.3 5.1 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.2 2.5 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.2 2.5 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.4 2.2 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 2.1 REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.1 2.0 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 2.0 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.2 1.9 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 1.8 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 1.8 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.9 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.9 REACTOME_TRANSPORT_OF_RIBONUCLEOPROTEINS_INTO_THE_HOST_NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0 0.7 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.1 0.4 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.1 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels