Motif ID: Bbx

Z-value: 0.316


Transcription factors associated with Bbx:

Gene SymbolEntrez IDGene Name
Bbx ENSMUSG00000022641.9 Bbx

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Bbxmm10_v2_chr16_-_50432340_50432409-0.632.1e-07Click!


Activity profile for motif Bbx.

activity profile for motif Bbx


Sorted Z-values histogram for motif Bbx

Sorted Z-values for motif Bbx



Network of associatons between targets according to the STRING database.



First level regulatory network of Bbx

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_+_21111452 4.492 ENSMUST00000075132.6
 Cdh12
cadherin 12
chr5_-_146585239 2.900 ENSMUST00000036211.6
 Gpr12
G-protein coupled receptor 12
chr13_-_52530827 2.701 ENSMUST00000057442.6
 Diras2
DIRAS family, GTP-binding RAS-like 2
chr18_+_37421418 2.476 ENSMUST00000053073.4
 Pcdhb11
protocadherin beta 11
chr10_+_86021961 1.595 ENSMUST00000130320.1
 Fbxo7
F-box protein 7
chr13_+_49608030 1.218 ENSMUST00000021822.5
 Ogn
osteoglycin
chrX_+_159708593 1.124 ENSMUST00000080394.6
 Sh3kbp1
SH3-domain kinase binding protein 1
chrX_+_140367494 1.082 ENSMUST00000141660.1
 Frmpd3
FERM and PDZ domain containing 3
chr17_+_57358682 1.051 ENSMUST00000086763.5
ENSMUST00000004850.7
 Emr1

EGF-like module containing, mucin-like, hormone receptor-like sequence 1

chrX_-_150814265 0.886 ENSMUST00000026302.6
ENSMUST00000129768.1
ENSMUST00000112699.2
 Maged2


melanoma antigen, family D, 2


chr6_+_124304646 0.787 ENSMUST00000112541.2
ENSMUST00000032234.2
 Cd163

CD163 antigen

chr8_+_70616816 0.776 ENSMUST00000052437.3
 Lrrc25
leucine rich repeat containing 25
chr2_+_136892168 0.673 ENSMUST00000099311.2
 Slx4ip
SLX4 interacting protein
chr1_+_180111339 0.601 ENSMUST00000145181.1
 Cdc42bpa
CDC42 binding protein kinase alpha
chr8_-_41054771 0.498 ENSMUST00000093534.4
 Mtus1
mitochondrial tumor suppressor 1
chr16_+_20693263 0.406 ENSMUST00000149543.1
ENSMUST00000118919.1
 Fam131a

family with sequence similarity 131, member A

chr12_+_103388656 0.363 ENSMUST00000101094.2
ENSMUST00000021620.6
 Otub2

OTU domain, ubiquitin aldehyde binding 2

chrX_-_107816238 0.333 ENSMUST00000120722.1
 2610002M06Rik
RIKEN cDNA 2610002M06 gene
chr11_+_105146893 0.330 ENSMUST00000100338.1
 Gm10842
predicted gene 10842
chr10_+_84622365 0.313 ENSMUST00000077175.5
 Polr3b
polymerase (RNA) III (DNA directed) polypeptide B
chr7_-_127708738 0.287 ENSMUST00000106282.1
 Bcl7c
B cell CLL/lymphoma 7C
chr17_+_40811089 0.188 ENSMUST00000024721.7
 Rhag
Rhesus blood group-associated A glycoprotein
chr5_-_108675569 0.157 ENSMUST00000051757.7
 Slc26a1
solute carrier family 26 (sulfate transporter), member 1
chr2_-_152830615 0.102 ENSMUST00000146380.1
ENSMUST00000134902.1
ENSMUST00000134357.1
ENSMUST00000109820.3
 Bcl2l1



BCL2-like 1



chr10_+_86022189 0.036 ENSMUST00000120344.1
ENSMUST00000117597.1
 Fbxo7

F-box protein 7

chr2_-_152830266 0.003 ENSMUST00000140436.1
 Bcl2l1
BCL2-like 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.6 GO:1903207 neuron death in response to hydrogen peroxide(GO:0036476) regulation of hydrogen peroxide-induced neuron death(GO:1903207) negative regulation of hydrogen peroxide-induced neuron death(GO:1903208)
0.1 0.9 GO:0070294 renal sodium ion absorption(GO:0070294)
0.1 0.2 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.1 4.5 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.8 GO:0006953 acute-phase response(GO:0006953)
0.0 0.4 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.0 0.1 GO:0046898 response to cycloheximide(GO:0046898)
0.0 0.2 GO:0019532 oxalate transport(GO:0019532)
0.0 0.6 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.0 0.5 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.0 2.5 GO:0007416 synapse assembly(GO:0007416)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.6 GO:1990037 Lewy body core(GO:1990037)
0.0 0.3 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.9 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.1 0.4 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.8 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.3 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 0.2 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.0 1.6 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.2 GO:0022842 leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842)
0.0 0.1 GO:0051434 BH3 domain binding(GO:0051434)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.1 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.5 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 1.2 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 1.1 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.3 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation