Motif ID: Bcl6

Z-value: 0.675


Transcription factors associated with Bcl6:

Gene SymbolEntrez IDGene Name
Bcl6 ENSMUSG00000022508.5 Bcl6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Bcl6mm10_v2_chr16_-_23988852_239888520.694.1e-09Click!


Activity profile for motif Bcl6.

activity profile for motif Bcl6


Sorted Z-values histogram for motif Bcl6

Sorted Z-values for motif Bcl6



Network of associatons between targets according to the STRING database.



First level regulatory network of Bcl6

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_169747634 8.527 ENSMUST00000027991.5
ENSMUST00000111357.1
 Rgs4

regulator of G-protein signaling 4

chr10_+_100015817 4.027 ENSMUST00000130190.1
ENSMUST00000020129.7
 Kitl

kit ligand

chr11_+_101245996 4.026 ENSMUST00000129680.1
 Ramp2
receptor (calcitonin) activity modifying protein 2
chr3_-_152982240 3.645 ENSMUST00000044278.5
 St6galnac5
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr3_-_80802789 3.607 ENSMUST00000107745.1
ENSMUST00000075316.4
 Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr4_-_64046925 3.329 ENSMUST00000107377.3
 Tnc
tenascin C
chrX_-_61185558 3.262 ENSMUST00000166381.1
 Cdr1
cerebellar degeneration related antigen 1
chr3_-_120886691 3.139 ENSMUST00000182099.1
ENSMUST00000183168.1
ENSMUST00000183276.1
ENSMUST00000182124.1
 6530403H02Rik



RIKEN cDNA 6530403H02 gene



chr1_-_175491130 3.097 ENSMUST00000027812.5
 Rgs7
regulator of G protein signaling 7
chr9_+_20868628 3.041 ENSMUST00000043911.7
 A230050P20Rik
RIKEN cDNA A230050P20 gene
chr4_+_42922253 2.998 ENSMUST00000139100.1
 N28178
expressed sequence N28178
chr18_+_37484955 2.995 ENSMUST00000053856.4
 Pcdhb17
protocadherin beta 17
chr6_-_13838432 2.950 ENSMUST00000115492.1
 Gpr85
G protein-coupled receptor 85
chr19_+_34217588 2.869 ENSMUST00000119603.1
 Stambpl1
STAM binding protein like 1
chr11_+_78499087 2.700 ENSMUST00000017488.4
 Vtn
vitronectin
chr9_+_107296682 2.665 ENSMUST00000168260.1
 Cish
cytokine inducible SH2-containing protein
chr10_+_58813359 2.648 ENSMUST00000135526.2
ENSMUST00000153031.1
 Sh3rf3

SH3 domain containing ring finger 3

chr4_+_42917234 2.588 ENSMUST00000107976.2
ENSMUST00000069184.2
 N28178

expressed sequence N28178

chr3_+_38886940 2.561 ENSMUST00000061260.7
 Fat4
FAT tumor suppressor homolog 4 (Drosophila)
chr4_+_43401232 2.457 ENSMUST00000125399.1
 Rusc2
RUN and SH3 domain containing 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 91 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.4 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.5 5.4 GO:0042572 retinol metabolic process(GO:0042572)
0.2 4.8 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.1 4.5 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.4 4.4 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
1.0 4.0 GO:0033024 mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
0.7 4.0 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.2 3.6 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.2 3.6 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0 3.5 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.8 3.3 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.0 3.1 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.1 3.0 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.2 2.7 GO:0097421 liver regeneration(GO:0097421)
0.6 2.6 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.0 2.5 GO:0007416 synapse assembly(GO:0007416)
0.8 2.3 GO:0071492 cellular response to UV-A(GO:0071492)
0.6 2.3 GO:1904457 positive regulation of neuronal action potential(GO:1904457)
0.4 2.3 GO:0007021 tubulin complex assembly(GO:0007021)
0.3 2.3 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.4 GO:0005614 interstitial matrix(GO:0005614)
0.3 4.4 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.8 4.0 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.0 3.7 GO:0000139 Golgi membrane(GO:0000139)
0.2 3.6 GO:0032279 asymmetric synapse(GO:0032279)
0.0 3.4 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 3.3 GO:0031672 A band(GO:0031672)
0.2 3.1 GO:0044292 dendrite terminus(GO:0044292)
0.0 2.9 GO:0005903 brush border(GO:0005903)
0.5 2.7 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.5 2.3 GO:0044316 cone cell pedicle(GO:0044316)
0.4 2.3 GO:0097512 cardiac myofibril(GO:0097512)
0.5 1.9 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 1.8 GO:0005811 lipid particle(GO:0005811)
0.5 1.6 GO:0005940 septin ring(GO:0005940)
0.1 1.6 GO:0005915 zonula adherens(GO:0005915)
0.1 1.4 GO:0097228 sperm principal piece(GO:0097228)
0.0 1.4 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 1.1 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.1 1.0 GO:0044754 autolysosome(GO:0044754)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 74 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.5 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 6.4 GO:0030507 spectrin binding(GO:0030507)
0.8 5.4 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 5.2 GO:0008237 metallopeptidase activity(GO:0008237)
0.6 4.5 GO:0097322 7SK snRNA binding(GO:0097322)
0.3 4.1 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.8 4.0 GO:0097643 amylin receptor activity(GO:0097643)
0.7 4.0 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.1 3.8 GO:0043014 alpha-tubulin binding(GO:0043014)
0.6 3.6 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.5 3.6 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.1 3.5 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.6 3.3 GO:0045545 syndecan binding(GO:0045545)
0.3 3.1 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 3.1 GO:0017137 Rab GTPase binding(GO:0017137)
0.6 2.3 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.3 2.3 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 2.3 GO:0030552 cAMP binding(GO:0030552)
0.4 2.2 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 2.1 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)

Gene overrepresentation in C2:CP category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 4.8 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.1 4.6 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 4.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.5 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 3.3 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.2 2.7 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.8 PID_INSULIN_PATHWAY Insulin Pathway
0.0 1.6 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.5 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.4 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.2 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.9 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.8 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.6 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.5 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.4 PID_IL4_2PATHWAY IL4-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.2 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 7.8 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.1 5.4 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 4.4 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.2 3.8 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.2 3.6 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 3.6 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 3.3 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 2.6 REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES Genes involved in Transmission across Chemical Synapses
0.0 2.2 REACTOME_TRIGLYCERIDE_BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.1 2.1 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 1.9 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 1.6 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 1.5 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 1.4 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 1.3 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.1 1.2 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.1 1.1 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 0.8 REACTOME_COPI_MEDIATED_TRANSPORT Genes involved in COPI Mediated Transport
0.1 0.8 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac