Motif ID: Bhlhe40
Z-value: 0.547
Transcription factors associated with Bhlhe40:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Bhlhe40 | ENSMUSG00000030103.5 | Bhlhe40 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Bhlhe40 | mm10_v2_chr6_+_108660616_108660682 | -0.34 | 1.2e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 2.5 | GO:0070829 | heterochromatin maintenance(GO:0070829) |
| 0.6 | 2.2 | GO:0060830 | ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830) myotome development(GO:0061055) |
| 0.3 | 0.8 | GO:0019482 | beta-alanine metabolic process(GO:0019482) |
| 0.3 | 2.8 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.2 | 4.9 | GO:0036295 | cellular response to increased oxygen levels(GO:0036295) |
| 0.2 | 0.5 | GO:2000510 | positive regulation of dendritic cell chemotaxis(GO:2000510) |
| 0.2 | 0.7 | GO:0072531 | pyrimidine-containing compound transmembrane transport(GO:0072531) |
| 0.1 | 0.4 | GO:1902219 | negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219) |
| 0.1 | 1.0 | GO:0030242 | pexophagy(GO:0030242) |
| 0.1 | 2.2 | GO:0035751 | regulation of lysosomal lumen pH(GO:0035751) |
| 0.1 | 0.9 | GO:0015808 | L-alanine transport(GO:0015808) |
| 0.1 | 0.7 | GO:0090521 | glomerular visceral epithelial cell migration(GO:0090521) |
| 0.1 | 0.8 | GO:0070494 | regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) |
| 0.1 | 0.3 | GO:0006419 | alanyl-tRNA aminoacylation(GO:0006419) |
| 0.1 | 1.1 | GO:0007035 | vacuolar acidification(GO:0007035) |
| 0.1 | 1.2 | GO:0070842 | aggresome assembly(GO:0070842) |
| 0.1 | 3.5 | GO:1902476 | chloride transmembrane transport(GO:1902476) |
| 0.1 | 1.4 | GO:0006622 | protein targeting to lysosome(GO:0006622) |
| 0.1 | 0.2 | GO:0071873 | response to norepinephrine(GO:0071873) |
| 0.1 | 0.6 | GO:0006020 | inositol metabolic process(GO:0006020) |
| 0.1 | 0.2 | GO:1903061 | regulation of protein lipidation(GO:1903059) positive regulation of protein lipidation(GO:1903061) positive regulation of neuronal action potential(GO:1904457) |
| 0.1 | 0.9 | GO:0031987 | locomotion involved in locomotory behavior(GO:0031987) |
| 0.0 | 0.3 | GO:0034058 | endosomal vesicle fusion(GO:0034058) |
| 0.0 | 0.2 | GO:0006689 | ganglioside catabolic process(GO:0006689) |
| 0.0 | 0.4 | GO:0061470 | T follicular helper cell differentiation(GO:0061470) |
| 0.0 | 0.9 | GO:0032011 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
| 0.0 | 0.9 | GO:0097178 | ruffle assembly(GO:0097178) |
| 0.0 | 0.4 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.0 | 0.6 | GO:0097352 | autophagosome maturation(GO:0097352) |
| 0.0 | 0.3 | GO:0090148 | membrane fission(GO:0090148) |
| 0.0 | 0.3 | GO:0001675 | acrosome assembly(GO:0001675) |
| 0.0 | 0.2 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
| 0.0 | 1.4 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.0 | 0.7 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
| 0.0 | 0.0 | GO:0002922 | positive regulation of humoral immune response(GO:0002922) |
| 0.0 | 3.5 | GO:0006869 | lipid transport(GO:0006869) |
| 0.0 | 0.1 | GO:0043162 | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 6.1 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
| 0.3 | 2.1 | GO:0033263 | CORVET complex(GO:0033263) |
| 0.2 | 2.2 | GO:0030991 | intraciliary transport particle A(GO:0030991) |
| 0.2 | 0.9 | GO:0032280 | symmetric synapse(GO:0032280) |
| 0.2 | 1.4 | GO:0031313 | extrinsic component of endosome membrane(GO:0031313) |
| 0.1 | 0.7 | GO:0044611 | nuclear pore inner ring(GO:0044611) |
| 0.1 | 0.5 | GO:0042824 | MHC class I peptide loading complex(GO:0042824) |
| 0.1 | 1.0 | GO:0030008 | TRAPP complex(GO:0030008) |
| 0.1 | 0.2 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 0.9 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
| 0.0 | 0.4 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.0 | 5.8 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.0 | 0.1 | GO:0005672 | transcription factor TFIIA complex(GO:0005672) |
| 0.0 | 0.8 | GO:0071339 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.0 | 0.2 | GO:0042582 | primary lysosome(GO:0005766) azurophil granule(GO:0042582) |
| 0.0 | 2.7 | GO:0034399 | nuclear periphery(GO:0034399) |
| 0.0 | 0.2 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.0 | 0.3 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 2.5 | GO:0004489 | methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489) |
| 0.3 | 0.9 | GO:0015173 | hydrogen:amino acid symporter activity(GO:0005280) aromatic amino acid transmembrane transporter activity(GO:0015173) |
| 0.3 | 6.1 | GO:0046961 | proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
| 0.2 | 3.5 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.2 | 0.6 | GO:0072345 | NAADP-sensitive calcium-release channel activity(GO:0072345) |
| 0.2 | 0.6 | GO:0000832 | inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724) |
| 0.2 | 0.9 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
| 0.1 | 0.4 | GO:0005128 | erythropoietin receptor binding(GO:0005128) |
| 0.1 | 0.9 | GO:0016308 | 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308) |
| 0.1 | 0.3 | GO:0004813 | alanine-tRNA ligase activity(GO:0004813) |
| 0.1 | 0.6 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
| 0.1 | 2.8 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.1 | 0.2 | GO:0004348 | glucosylceramidase activity(GO:0004348) |
| 0.1 | 1.3 | GO:0000030 | mannosyltransferase activity(GO:0000030) |
| 0.0 | 0.9 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.0 | 1.7 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.0 | 0.1 | GO:0004616 | phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616) |
| 0.0 | 0.2 | GO:0004563 | beta-N-acetylhexosaminidase activity(GO:0004563) |
| 0.0 | 0.7 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.0 | 3.5 | GO:0042626 | ATPase activity, coupled to transmembrane movement of substances(GO:0042626) |
| 0.0 | 0.3 | GO:0030976 | thiamine pyrophosphate binding(GO:0030976) |
| 0.0 | 0.7 | GO:0015215 | nucleotide transmembrane transporter activity(GO:0015215) |
| 0.0 | 0.7 | GO:0008373 | sialyltransferase activity(GO:0008373) |
| 0.0 | 0.2 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 0.0 | 0.8 | GO:0016620 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620) |
| 0.0 | 0.0 | GO:0031871 | proteinase activated receptor binding(GO:0031871) |
| 0.0 | 0.5 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.0 | 0.6 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
| 0.0 | 0.5 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.0 | 0.5 | GO:0004521 | endoribonuclease activity(GO:0004521) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | PID_P38_GAMMA_DELTA_PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 0.9 | PID_ARF6_DOWNSTREAM_PATHWAY | Arf6 downstream pathway |
| 0.0 | 0.9 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 0.4 | PID_EPO_PATHWAY | EPO signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 6.7 | REACTOME_TRANSFERRIN_ENDOCYTOSIS_AND_RECYCLING | Genes involved in Transferrin endocytosis and recycling |
| 0.1 | 1.8 | REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.0 | 0.4 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.0 | 0.8 | REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 2.2 | REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 1.0 | REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA | Genes involved in G beta:gamma signalling through PLC beta |
| 0.0 | 0.9 | REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 0.7 | REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
| 0.0 | 0.2 | REACTOME_KERATAN_SULFATE_DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.0 | 0.3 | REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
