Motif ID: Bhlhe40

Z-value: 0.547


Transcription factors associated with Bhlhe40:

Gene SymbolEntrez IDGene Name
Bhlhe40 ENSMUSG00000030103.5 Bhlhe40

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Bhlhe40mm10_v2_chr6_+_108660616_108660682-0.341.2e-02Click!


Activity profile for motif Bhlhe40.

activity profile for motif Bhlhe40


Sorted Z-values histogram for motif Bhlhe40

Sorted Z-values for motif Bhlhe40



Network of associatons between targets according to the STRING database.



First level regulatory network of Bhlhe40

PNG image of the network

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Top targets:


Showing 1 to 20 of 95 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_148038769 4.306 ENSMUST00000030879.5
ENSMUST00000137724.1
Clcn6

chloride channel 6

chr7_+_121707189 3.752 ENSMUST00000065310.2
1700069B07Rik
RIKEN cDNA 1700069B07 gene
chr5_+_65199691 2.246 ENSMUST00000041892.8
Wdr19
WD repeat domain 19
chr11_+_97450136 2.211 ENSMUST00000107601.1
Arhgap23
Rho GTPase activating protein 23
chr11_-_110095937 2.103 ENSMUST00000106664.3
ENSMUST00000046223.7
ENSMUST00000106662.1
Abca8a


ATP-binding cassette, sub-family A (ABC1), member 8a


chr16_-_44139630 1.920 ENSMUST00000137557.1
ENSMUST00000147025.1
Atp6v1a

ATPase, H+ transporting, lysosomal V1 subunit A

chr16_-_44139003 1.905 ENSMUST00000124102.1
Atp6v1a
ATPase, H+ transporting, lysosomal V1 subunit A
chr5_-_123572976 1.809 ENSMUST00000031388.8
Vps33a
vacuolar protein sorting 33A (yeast)
chr16_+_8830093 1.523 ENSMUST00000023150.5
1810013L24Rik
RIKEN cDNA 1810013L24 gene
chr8_+_85036906 1.431 ENSMUST00000093360.4
Tnpo2
transportin 2 (importin 3, karyopherin beta 2b)
chr3_-_10440054 1.422 ENSMUST00000099223.4
ENSMUST00000029047.6
Snx16

sorting nexin 16

chr4_+_148039097 1.402 ENSMUST00000141283.1
Mthfr
5,10-methylenetetrahydrofolate reductase
chr11_-_110095974 1.401 ENSMUST00000100287.2
Abca8a
ATP-binding cassette, sub-family A (ABC1), member 8a
chr8_+_85037151 1.399 ENSMUST00000166592.1
Tnpo2
transportin 2 (importin 3, karyopherin beta 2b)
chrX_-_136203637 1.381 ENSMUST00000151592.1
ENSMUST00000131510.1
ENSMUST00000066819.4
Tceal5


transcription elongation factor A (SII)-like 5


chr10_-_80139347 1.325 ENSMUST00000105369.1
Dos
downstream of Stk11
chr16_+_5233615 1.268 ENSMUST00000100196.2
ENSMUST00000049207.8
Alg1

asparagine-linked glycosylation 1 (beta-1,4-mannosyltransferase)

chr5_+_123252087 1.231 ENSMUST00000121964.1
Wdr66
WD repeat domain 66
chr17_+_70561739 1.199 ENSMUST00000097288.2
Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr7_+_35802593 1.149 ENSMUST00000052454.2
E130304I02Rik
RIKEN cDNA E130304I02 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.9 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.1 3.5 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 3.5 GO:0006869 lipid transport(GO:0006869)
0.3 2.8 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.6 2.5 GO:0070829 heterochromatin maintenance(GO:0070829)
0.6 2.2 GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830) myotome development(GO:0061055)
0.1 2.2 GO:0035751 regulation of lysosomal lumen pH(GO:0035751)
0.1 1.4 GO:0006622 protein targeting to lysosome(GO:0006622)
0.0 1.4 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 1.2 GO:0070842 aggresome assembly(GO:0070842)
0.1 1.1 GO:0007035 vacuolar acidification(GO:0007035)
0.1 1.0 GO:0030242 pexophagy(GO:0030242)
0.1 0.9 GO:0015808 L-alanine transport(GO:0015808)
0.1 0.9 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.0 0.9 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.9 GO:0097178 ruffle assembly(GO:0097178)
0.3 0.8 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.1 0.8 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.2 0.7 GO:0072531 pyrimidine-containing compound transmembrane transport(GO:0072531)
0.1 0.7 GO:0090521 glomerular visceral epithelial cell migration(GO:0090521)

Gene overrepresentation in cellular_component category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 6.1 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 5.8 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 2.7 GO:0034399 nuclear periphery(GO:0034399)
0.2 2.2 GO:0030991 intraciliary transport particle A(GO:0030991)
0.3 2.1 GO:0033263 CORVET complex(GO:0033263)
0.2 1.4 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.1 1.0 GO:0030008 TRAPP complex(GO:0030008)
0.2 0.9 GO:0032280 symmetric synapse(GO:0032280)
0.0 0.9 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.8 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.1 0.7 GO:0044611 nuclear pore inner ring(GO:0044611)
0.1 0.5 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.0 0.4 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.3 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.1 0.2 GO:0043202 lysosomal lumen(GO:0043202)
0.0 0.2 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 0.2 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.1 GO:0005672 transcription factor TFIIA complex(GO:0005672)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 6.1 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.2 3.5 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 3.5 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.1 2.8 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.8 2.5 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.0 1.7 GO:0050699 WW domain binding(GO:0050699)
0.1 1.3 GO:0000030 mannosyltransferase activity(GO:0000030)
0.3 0.9 GO:0015173 hydrogen:amino acid symporter activity(GO:0005280) aromatic amino acid transmembrane transporter activity(GO:0015173)
0.2 0.9 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.1 0.9 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0 0.9 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.8 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.0 0.7 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.7 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)
0.0 0.7 GO:0008373 sialyltransferase activity(GO:0008373)
0.2 0.6 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.2 0.6 GO:0000832 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.1 0.6 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.6 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.5 GO:0050681 androgen receptor binding(GO:0050681)

Gene overrepresentation in C2:CP category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.9 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.8 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.4 PID_EPO_PATHWAY EPO signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 6.7 REACTOME_TRANSFERRIN_ENDOCYTOSIS_AND_RECYCLING Genes involved in Transferrin endocytosis and recycling
0.0 2.2 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 1.8 REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 1.0 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.9 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.8 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.7 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.4 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.3 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.2 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation