Motif ID: Brca1

Z-value: 0.388


Transcription factors associated with Brca1:

Gene SymbolEntrez IDGene Name
Brca1 ENSMUSG00000017146.6 Brca1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Brca1mm10_v2_chr11_-_101551837_1015518930.172.3e-01Click!


Activity profile for motif Brca1.

activity profile for motif Brca1


Sorted Z-values histogram for motif Brca1

Sorted Z-values for motif Brca1



Network of associatons between targets according to the STRING database.



First level regulatory network of Brca1

PNG image of the network

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Top targets:


Showing 1 to 20 of 183 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 6.017 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr11_+_44617310 1.824 ENSMUST00000081265.5
ENSMUST00000101326.3
ENSMUST00000109268.1
 Ebf1


early B cell factor 1


chr1_-_75278345 1.418 ENSMUST00000039534.4
 Resp18
regulated endocrine-specific protein 18
chr18_-_47333311 1.305 ENSMUST00000126684.1
ENSMUST00000156422.1
 Sema6a

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

chr7_-_144939823 1.233 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr11_-_106998483 0.946 ENSMUST00000124541.1
 Kpna2
karyopherin (importin) alpha 2
chr14_-_67715585 0.900 ENSMUST00000163100.1
ENSMUST00000132705.1
ENSMUST00000124045.1
 Cdca2


cell division cycle associated 2


chr2_-_105399286 0.835 ENSMUST00000006128.6
 Rcn1
reticulocalbin 1
chr17_-_70853482 0.798 ENSMUST00000118283.1
 Tgif1
TGFB-induced factor homeobox 1
chr8_-_47990535 0.717 ENSMUST00000057561.7
 Wwc2
WW, C2 and coiled-coil domain containing 2
chr19_-_24225015 0.713 ENSMUST00000099558.4
 Tjp2
tight junction protein 2
chr16_-_16829276 0.693 ENSMUST00000023468.5
 Spag6
sperm associated antigen 6
chr11_-_98625661 0.657 ENSMUST00000104933.1
 Gm12355
predicted gene 12355
chr1_+_74791516 0.645 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr6_+_14901344 0.629 ENSMUST00000115477.1
 Foxp2
forkhead box P2
chr3_+_87906321 0.607 ENSMUST00000005017.8
 Hdgf
hepatoma-derived growth factor
chr11_+_97415527 0.572 ENSMUST00000121799.1
 Arhgap23
Rho GTPase activating protein 23
chr16_+_44394771 0.569 ENSMUST00000099742.2
 Wdr52
WD repeat domain 52
chr12_+_52097737 0.565 ENSMUST00000040090.9
 Nubpl
nucleotide binding protein-like
chr13_-_100775844 0.564 ENSMUST00000075550.3
 Cenph
centromere protein H

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 6.0 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 1.3 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.2 1.2 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.1 1.0 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.1 0.9 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.8 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.2 0.7 GO:1903011 negative regulation of bone development(GO:1903011)
0.1 0.7 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.1 0.6 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.1 0.6 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.0 0.6 GO:0051382 kinetochore assembly(GO:0051382)
0.0 0.6 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 0.6 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.1 0.5 GO:0021764 amygdala development(GO:0021764)
0.1 0.5 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.1 0.5 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.1 0.5 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.1 0.5 GO:0035372 protein localization to microtubule(GO:0035372)
0.1 0.5 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.5 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.3 1.4 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 1.2 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 1.2 GO:0005643 nuclear pore(GO:0005643)
0.0 0.7 GO:0005921 gap junction(GO:0005921)
0.2 0.5 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.1 0.5 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.5 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.5 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.5 GO:0030673 axolemma(GO:0030673)
0.1 0.4 GO:0000799 nuclear condensin complex(GO:0000799)
0.0 0.4 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 0.4 GO:0042382 paraspeckles(GO:0042382)
0.0 0.4 GO:0031528 microvillus membrane(GO:0031528)
0.1 0.3 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.1 0.3 GO:0000125 PCAF complex(GO:0000125)
0.0 0.3 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 0.3 GO:0001739 sex chromatin(GO:0001739)
0.0 0.3 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.3 GO:0005689 U12-type spliceosomal complex(GO:0005689)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 2.2 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.1 2.0 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 1.3 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 1.2 GO:0070064 proline-rich region binding(GO:0070064)
0.0 1.0 GO:0005109 frizzled binding(GO:0005109)
0.2 0.6 GO:0003953 NAD+ nucleosidase activity(GO:0003953)
0.1 0.6 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.6 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.6 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.1 0.5 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.1 0.5 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.1 0.5 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.1 0.5 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.1 0.5 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.0 0.5 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.1 0.4 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.0 0.4 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.4 GO:1990405 protein antigen binding(GO:1990405)
0.0 0.4 GO:0034185 apolipoprotein binding(GO:0034185)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 1.2 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.9 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.3 PID_MYC_PATHWAY C-MYC pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.8 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.5 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.3 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 1.2 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 1.0 REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.0 0.9 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 0.8 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.8 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.8 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 0.7 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.6 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 0.5 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.5 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.5 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.5 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.4 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.4 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.3 REACTOME_REGULATION_OF_HYPOXIA_INDUCIBLE_FACTOR_HIF_BY_OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.0 0.3 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.2 REACTOME_REGULATION_OF_IFNG_SIGNALING Genes involved in Regulation of IFNG signaling