Motif ID: Cdx2

Z-value: 0.437


Transcription factors associated with Cdx2:

Gene SymbolEntrez IDGene Name
Cdx2 ENSMUSG00000029646.3 Cdx2



Activity profile for motif Cdx2.

activity profile for motif Cdx2


Sorted Z-values histogram for motif Cdx2

Sorted Z-values for motif Cdx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Cdx2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_64046925 3.739 ENSMUST00000107377.3
 Tnc
tenascin C
chr1_-_186705980 2.744 ENSMUST00000045288.8
 Tgfb2
transforming growth factor, beta 2
chr4_+_144893127 2.584 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr12_+_85473883 2.528 ENSMUST00000021674.6
 Fos
FBJ osteosarcoma oncogene
chr15_+_3270767 1.811 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr16_-_44016387 1.646 ENSMUST00000036174.3
 Gramd1c
GRAM domain containing 1C
chr3_+_118433797 1.507 ENSMUST00000180593.1
ENSMUST00000181926.1
ENSMUST00000181060.1
ENSMUST00000181310.1
 Gm26871



predicted gene, 26871



chr4_-_24430838 1.454 ENSMUST00000183964.1
 RP23-35K5.2
RP23-35K5.2
chr2_+_4300462 1.323 ENSMUST00000175669.1
 Frmd4a
FERM domain containing 4A
chr14_+_80000292 1.125 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr6_+_17491216 1.064 ENSMUST00000080469.5
 Met
met proto-oncogene
chr2_-_59948155 1.042 ENSMUST00000153136.1
 Baz2b
bromodomain adjacent to zinc finger domain, 2B
chr5_+_13399309 0.977 ENSMUST00000030714.7
ENSMUST00000141968.1
 Sema3a

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A

chr3_+_88965812 0.836 ENSMUST00000090933.4
 Ash1l
ash1 (absent, small, or homeotic)-like (Drosophila)
chr13_+_63282142 0.792 ENSMUST00000159152.1
 2010111I01Rik
RIKEN cDNA 2010111I01 gene
chr13_+_23934434 0.640 ENSMUST00000072391.1
 Hist1h2aa
histone cluster 1, H2aa
chr3_+_40540751 0.634 ENSMUST00000091186.3
 Intu
inturned planar cell polarity effector homolog (Drosophila)
chr2_+_31759993 0.628 ENSMUST00000124089.1
 Abl1
c-abl oncogene 1, non-receptor tyrosine kinase
chr1_-_163289214 0.626 ENSMUST00000183691.1
 Prrx1
paired related homeobox 1
chr14_-_54686060 0.622 ENSMUST00000125265.1
 Acin1
apoptotic chromatin condensation inducer 1
chr11_-_79504078 0.607 ENSMUST00000164465.2
 Omg
oligodendrocyte myelin glycoprotein
chr12_-_102878406 0.570 ENSMUST00000045652.6
 Btbd7
BTB (POZ) domain containing 7
chrX_+_13632769 0.446 ENSMUST00000096492.3
 Gpr34
G protein-coupled receptor 34
chr15_-_50882806 0.429 ENSMUST00000184885.1
 Trps1
trichorhinophalangeal syndrome I (human)
chr11_+_87663087 0.390 ENSMUST00000165679.1
 Rnf43
ring finger protein 43
chr18_+_37755718 0.368 ENSMUST00000061279.7
 Pcdhga9
protocadherin gamma subfamily A, 9
chr18_+_65582239 0.365 ENSMUST00000182684.1
 Zfp532
zinc finger protein 532
chrX_+_139684980 0.355 ENSMUST00000096313.3
 Tbc1d8b
TBC1 domain family, member 8B
chr6_+_42286676 0.306 ENSMUST00000031894.6
 Clcn1
chloride channel 1
chr18_+_37513652 0.305 ENSMUST00000061405.4
 Pcdhb21
protocadherin beta 21
chr7_-_139582790 0.248 ENSMUST00000106095.2
 Nkx6-2
NK6 homeobox 2
chr2_+_31759932 0.241 ENSMUST00000028190.6
 Abl1
c-abl oncogene 1, non-receptor tyrosine kinase
chr18_+_65582281 0.194 ENSMUST00000183319.1
 Zfp532
zinc finger protein 532
chr12_+_77238093 0.169 ENSMUST00000177595.1
ENSMUST00000171770.2
 Fut8

fucosyltransferase 8

chr6_+_42286709 0.154 ENSMUST00000163936.1
 Clcn1
chloride channel 1
chr18_+_65582390 0.153 ENSMUST00000169679.1
ENSMUST00000183326.1
 Zfp532

zinc finger protein 532

chr1_-_30863256 0.137 ENSMUST00000088310.3
 Phf3
PHD finger protein 3
chr5_+_121777929 0.125 ENSMUST00000160821.1
 Atxn2
ataxin 2
chr8_-_105933832 0.101 ENSMUST00000034368.6
 Ctrl
chymotrypsin-like
chr6_+_38918969 0.090 ENSMUST00000003017.6
 Tbxas1
thromboxane A synthase 1, platelet
chr9_-_21989427 0.084 ENSMUST00000045726.6
 Rgl3
ral guanine nucleotide dissociation stimulator-like 3
chr13_-_107890059 0.054 ENSMUST00000105097.2
 Zswim6
zinc finger SWIM-type containing 6
chr2_-_24048857 0.049 ENSMUST00000114497.1
 Hnmt
histamine N-methyltransferase
chr10_+_69787431 0.039 ENSMUST00000183240.1
 Ank3
ankyrin 3, epithelial
chr8_+_94386438 0.036 ENSMUST00000161576.1
 Herpud1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr19_+_8850785 0.034 ENSMUST00000096257.2
 Lrrn4cl
LRRN4 C-terminal like
chr6_-_122340525 0.033 ENSMUST00000112600.2
 Phc1
polyhomeotic-like 1 (Drosophila)
chr9_-_45936049 0.000 ENSMUST00000034590.2
 Tagln
transgelin

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.7 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.9 2.7 GO:1902256 endocardial cushion fusion(GO:0003274) apoptotic process involved in outflow tract morphogenesis(GO:0003275) atrial septum primum morphogenesis(GO:0003289) positive regulation of catagen(GO:0051795) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256)
0.3 0.9 GO:1900275 negative regulation of phospholipase C activity(GO:1900275)
0.2 2.6 GO:0042572 retinol metabolic process(GO:0042572)
0.2 1.0 GO:0021856 cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) facioacoustic ganglion development(GO:1903375)
0.2 1.1 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.1 2.5 GO:0035994 response to muscle stretch(GO:0035994)
0.1 0.8 GO:0002674 negative regulation of acute inflammatory response(GO:0002674)
0.1 0.4 GO:0035590 purinergic nucleotide receptor signaling pathway(GO:0035590)
0.1 0.6 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.1 0.4 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.1 0.6 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.1 0.6 GO:0060693 regulation of branching involved in salivary gland morphogenesis(GO:0060693)
0.0 0.6 GO:0048664 neuron fate determination(GO:0048664)
0.0 0.5 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.2 GO:0046368 GDP-L-fucose metabolic process(GO:0046368)
0.0 0.9 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.0 1.3 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.8 GO:0043171 peptide catabolic process(GO:0043171)
0.0 1.1 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 0.1 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.0 0.0 GO:0001692 histamine metabolic process(GO:0001692) imidazole-containing compound catabolic process(GO:0052805)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.5 GO:0035976 AP1 complex(GO:0035976)
0.2 3.7 GO:0005614 interstitial matrix(GO:0005614)
0.1 1.1 GO:0042581 specific granule(GO:0042581)
0.1 0.6 GO:0061574 ASAP complex(GO:0061574)
0.0 2.7 GO:0005604 basement membrane(GO:0005604)
0.0 1.1 GO:0009925 basal plasma membrane(GO:0009925)
0.0 2.2 GO:0005923 bicellular tight junction(GO:0005923)
0.0 0.2 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.5 GO:0034707 chloride channel complex(GO:0034707)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.7 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.6 3.7 GO:0045545 syndecan binding(GO:0045545)
0.4 2.6 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.3 1.1 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.1 0.8 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.1 1.0 GO:0038191 neuropilin binding(GO:0038191)
0.1 0.9 GO:0070097 delta-catenin binding(GO:0070097)
0.1 2.5 GO:0070412 R-SMAD binding(GO:0070412)
0.1 0.4 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.8 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.5 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.6 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.2 GO:0008417 fucosyltransferase activity(GO:0008417)
0.0 0.1 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.7 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 2.5 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.1 3.7 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 3.1 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.1 PID_ARF6_PATHWAY Arf6 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.5 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 1.0 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 3.7 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 2.7 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 1.1 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 0.9 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 0.6 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins