Motif ID: Cebpa_Cebpg

Z-value: 0.577

Transcription factors associated with Cebpa_Cebpg:

Gene SymbolEntrez IDGene Name
Cebpa ENSMUSG00000034957.9 Cebpa
Cebpg ENSMUSG00000056216.8 Cebpg

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Cebpgmm10_v2_chr7_-_35056467_35056556-0.524.3e-05Click!
Cebpamm10_v2_chr7_+_35119285_351193010.211.3e-01Click!


Activity profile for motif Cebpa_Cebpg.

activity profile for motif Cebpa_Cebpg


Sorted Z-values histogram for motif Cebpa_Cebpg

Sorted Z-values for motif Cebpa_Cebpg



Network of associatons between targets according to the STRING database.



First level regulatory network of Cebpa_Cebpg

PNG image of the network

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Top targets:


Showing 1 to 20 of 167 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_57239310 5.607 ENSMUST00000111559.1
 Ablim1
actin-binding LIM protein 1
chr9_-_121495678 4.284 ENSMUST00000035120.4
 Cck
cholecystokinin
chr6_+_17463749 3.522 ENSMUST00000115443.1
 Met
met proto-oncogene
chrX_-_162565514 3.069 ENSMUST00000154424.1
 Reps2
RALBP1 associated Eps domain containing protein 2
chr13_-_117025505 2.985 ENSMUST00000022239.6
 Parp8
poly (ADP-ribose) polymerase family, member 8
chr1_-_22315792 2.973 ENSMUST00000164877.1
 Rims1
regulating synaptic membrane exocytosis 1
chr7_-_103813913 2.866 ENSMUST00000098192.3
 Hbb-bt
hemoglobin, beta adult t chain
chr1_-_38821215 2.666 ENSMUST00000039612.4
 Lonrf2
LON peptidase N-terminal domain and ring finger 2
chr12_+_74297474 2.489 ENSMUST00000072100.3
 Dbpht2
DNA binding protein with his-thr domain
chr14_+_65970610 2.010 ENSMUST00000127387.1
 Clu
clusterin
chr4_-_15149051 1.882 ENSMUST00000041606.7
 Necab1
N-terminal EF-hand calcium binding protein 1
chr14_+_65971049 1.758 ENSMUST00000128539.1
 Clu
clusterin
chr2_-_45117349 1.623 ENSMUST00000176438.2
 Zeb2
zinc finger E-box binding homeobox 2
chr1_+_169655493 1.527 ENSMUST00000027997.3
 Rgs5
regulator of G-protein signaling 5
chr4_-_15149755 1.512 ENSMUST00000108273.1
 Necab1
N-terminal EF-hand calcium binding protein 1
chr13_-_49309217 1.482 ENSMUST00000110087.2
 Fgd3
FYVE, RhoGEF and PH domain containing 3
chr1_-_71653162 1.358 ENSMUST00000055226.6
 Fn1
fibronectin 1
chr2_-_65567465 1.332 ENSMUST00000066432.5
 Scn3a
sodium channel, voltage-gated, type III, alpha
chr4_+_85205120 1.293 ENSMUST00000107188.3
 Sh3gl2
SH3-domain GRB2-like 2
chr14_+_65970804 1.274 ENSMUST00000138191.1
 Clu
clusterin

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 80 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 6.2 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.0 5.4 GO:0060271 cilium morphogenesis(GO:0060271)
0.4 4.3 GO:0051901 positive regulation of mitochondrial depolarization(GO:0051901)
0.5 3.5 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.7 3.0 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.5 2.5 GO:0046684 response to pyrethroid(GO:0046684)
0.0 2.4 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.4 2.0 GO:0033140 negative regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033140)
0.2 1.8 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.4 1.7 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.3 1.6 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.0 1.5 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.5 1.4 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931) calcium-independent cell-matrix adhesion(GO:0007161) transforming growth factor-beta secretion(GO:0038044)
0.2 1.3 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.2 1.2 GO:0005513 detection of calcium ion(GO:0005513)
0.1 1.2 GO:1901898 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 1.2 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.2 1.1 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
0.1 1.1 GO:0071420 cellular response to histamine(GO:0071420)
0.1 1.0 GO:0006561 proline biosynthetic process(GO:0006561)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 6.2 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.1 5.9 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.3 4.3 GO:0043203 axon hillock(GO:0043203)
0.6 3.0 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
0.7 2.9 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 2.6 GO:0009925 basal plasma membrane(GO:0009925)
0.2 2.5 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 2.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 1.8 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.5 1.4 GO:0005577 fibrinogen complex(GO:0005577)
0.0 1.2 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 1.2 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.2 1.1 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.1 1.1 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.1 1.1 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 0.9 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.9 GO:0005720 nuclear heterochromatin(GO:0005720)
0.2 0.6 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.0 0.6 GO:0097440 apical dendrite(GO:0097440)
0.1 0.5 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.8 GO:0005509 calcium ion binding(GO:0005509)
0.3 6.2 GO:0051787 misfolded protein binding(GO:0051787)
0.2 5.0 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.9 3.5 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.1 3.0 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.7 2.9 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.0 2.9 GO:0044325 ion channel binding(GO:0044325)
0.1 2.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 2.5 GO:0031402 sodium ion binding(GO:0031402)
0.0 1.8 GO:0030507 spectrin binding(GO:0030507)
0.2 1.7 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 1.6 GO:0070412 R-SMAD binding(GO:0070412)
0.0 1.5 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.2 1.4 GO:0045340 mercury ion binding(GO:0045340)
0.2 1.2 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1 1.2 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 1.2 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 1.1 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.1 1.1 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 1.1 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)

Gene overrepresentation in C2:CP category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.0 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 3.5 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.1 1.7 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.6 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.3 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 1.1 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 0.6 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.6 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.6 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 0.5 PID_FOXO_PATHWAY FoxO family signaling
0.0 0.5 PID_AVB3_INTEGRIN_PATHWAY Integrins in angiogenesis
0.0 0.4 PID_PI3KCI_AKT_PATHWAY Class I PI3K signaling events mediated by Akt
0.0 0.2 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.2 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.2 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.2 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 5.2 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 3.5 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.1 3.2 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.3 3.0 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 1.8 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 1.6 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.1 1.4 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.1 1.3 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 1.3 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 1.2 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 1.2 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 1.2 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 1.1 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 0.9 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.8 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.8 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.8 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.7 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.6 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions