Motif ID: Cenpb

Z-value: 1.245


Transcription factors associated with Cenpb:

Gene SymbolEntrez IDGene Name
Cenpb ENSMUSG00000068267.4 Cenpb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Cenpbmm10_v2_chr2_-_131179985_131180092-0.283.8e-02Click!


Activity profile for motif Cenpb.

activity profile for motif Cenpb


Sorted Z-values histogram for motif Cenpb

Sorted Z-values for motif Cenpb



Network of associatons between targets according to the STRING database.



First level regulatory network of Cenpb

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_98662227 36.101 ENSMUST00000099684.3
 Gm10801
predicted gene 10801
chr2_+_172550991 20.121 ENSMUST00000170744.1
 Tfap2c
transcription factor AP-2, gamma
chr14_+_65805832 9.818 ENSMUST00000022612.3
 Pbk
PDZ binding kinase
chr8_-_87959560 8.647 ENSMUST00000109655.2
 Zfp423
zinc finger protein 423
chr14_+_65806066 8.008 ENSMUST00000139644.1
 Pbk
PDZ binding kinase
chr9_-_8004585 7.940 ENSMUST00000086580.5
ENSMUST00000065353.6
 Yap1

yes-associated protein 1

chr6_+_66535418 7.760 ENSMUST00000101343.1
 Mad2l1
MAD2 mitotic arrest deficient-like 1
chr13_+_48261427 7.422 ENSMUST00000021810.1
 Id4
inhibitor of DNA binding 4
chr16_-_17125106 6.290 ENSMUST00000093336.6
 2610318N02Rik
RIKEN cDNA 2610318N02 gene
chr10_+_67979709 6.211 ENSMUST00000117086.1
 Rtkn2
rhotekin 2
chr8_-_25201349 6.166 ENSMUST00000084512.4
ENSMUST00000084030.4
 Tacc1

transforming, acidic coiled-coil containing protein 1

chr1_-_138848576 5.836 ENSMUST00000112030.2
 Lhx9
LIM homeobox protein 9
chr10_+_25359798 5.599 ENSMUST00000053748.8
 Epb4.1l2
erythrocyte protein band 4.1-like 2
chr1_+_184034381 5.536 ENSMUST00000048655.7
 Dusp10
dual specificity phosphatase 10
chr12_-_45074112 5.490 ENSMUST00000120531.1
ENSMUST00000143376.1
 Stxbp6

syntaxin binding protein 6 (amisyn)

chr8_+_12395287 5.416 ENSMUST00000180353.1
 Sox1
SRY-box containing gene 1
chr13_-_23698454 4.920 ENSMUST00000102967.1
 Hist1h4c
histone cluster 1, H4c
chr10_+_67979592 4.888 ENSMUST00000105437.1
 Rtkn2
rhotekin 2
chr5_-_99037342 4.860 ENSMUST00000161490.1
 Prkg2
protein kinase, cGMP-dependent, type II
chr2_-_26503814 4.841 ENSMUST00000028288.4
 Notch1
notch 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 121 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.7 20.1 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.3 17.0 GO:0070303 negative regulation of stress-activated MAPK cascade(GO:0032873) negative regulation of stress-activated protein kinase signaling cascade(GO:0070303)
0.8 9.9 GO:0051601 exocyst localization(GO:0051601)
1.3 7.9 GO:0060242 contact inhibition(GO:0060242)
0.9 7.8 GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
1.9 7.4 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
0.3 6.2 GO:0022027 interkinetic nuclear migration(GO:0022027)
1.2 5.8 GO:0035262 gonad morphogenesis(GO:0035262)
1.1 5.5 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.4 5.4 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.1 5.4 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.6 5.3 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.5 5.1 GO:1903298 regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903297) negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903298)
0.7 4.9 GO:2001225 cellular hypotonic response(GO:0071476) regulation of chloride transport(GO:2001225)
0.3 4.9 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
1.6 4.8 GO:0003219 atrioventricular node development(GO:0003162) cardiac right ventricle formation(GO:0003219)
1.6 4.8 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) DNA replication preinitiation complex assembly(GO:0071163) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.1 4.6 GO:0007043 cell-cell junction assembly(GO:0007043)
0.1 4.5 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.1 4.5 GO:0006879 cellular iron ion homeostasis(GO:0006879)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 26.0 GO:0005739 mitochondrion(GO:0005739)
0.1 10.4 GO:0005643 nuclear pore(GO:0005643)
0.5 9.9 GO:0000145 exocyst(GO:0000145)
2.6 7.9 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.5 6.6 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 5.0 GO:0016607 nuclear speck(GO:0016607)
0.1 4.9 GO:0000788 nuclear nucleosome(GO:0000788)
1.6 4.8 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
1.0 4.8 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 4.7 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.7 4.4 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.1 4.2 GO:0005657 replication fork(GO:0005657)
1.0 4.0 GO:0008537 proteasome activator complex(GO:0008537)
0.0 4.0 GO:0005923 bicellular tight junction(GO:0005923)
0.3 3.8 GO:0042555 MCM complex(GO:0042555)
0.2 3.7 GO:0000800 lateral element(GO:0000800)
0.2 3.1 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.2 3.1 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.1 2.8 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 2.8 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 84 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 20.1 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.6 10.8 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 10.2 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.3 7.9 GO:0070064 proline-rich region binding(GO:0070064)
0.0 6.3 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.4 5.5 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
1.2 4.9 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.3 4.8 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 4.8 GO:0005112 Notch binding(GO:0005112)
0.0 4.4 GO:0003682 chromatin binding(GO:0003682)
1.4 4.2 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.4 4.0 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 3.8 GO:0017025 TBP-class protein binding(GO:0017025)
0.5 3.7 GO:0000150 recombinase activity(GO:0000150)
0.4 3.6 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.0 3.6 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.9 3.5 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.1 3.3 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.3 3.2 GO:0070700 BMP receptor binding(GO:0070700)
0.0 3.2 GO:0003735 structural constituent of ribosome(GO:0003735)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 19.8 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.3 15.9 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 5.9 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.1 5.2 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 4.8 PID_ATR_PATHWAY ATR signaling pathway
0.1 4.5 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.5 4.2 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 4.1 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.3 3.2 PID_ALK2_PATHWAY ALK2 signaling events
0.0 3.1 PID_P53_REGULATION_PATHWAY p53 pathway
0.1 2.5 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.1 2.0 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 2.0 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.8 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.7 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 1.3 PID_FGF_PATHWAY FGF signaling pathway
0.1 1.1 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 1.0 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 1.0 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 0.9 PID_MYC_PATHWAY C-MYC pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 8.6 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.3 7.9 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.4 7.8 REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.1 7.7 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.1 7.2 REACTOME_METABOLISM_OF_NON_CODING_RNA Genes involved in Metabolism of non-coding RNA
0.2 5.9 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 5.3 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.3 4.9 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.1 4.9 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.4 4.4 REACTOME_SIGNALING_BY_EGFR_IN_CANCER Genes involved in Signaling by EGFR in Cancer
0.4 4.2 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.2 4.0 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.2 3.7 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 3.6 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.2 2.8 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 2.6 REACTOME_TRANSLATION Genes involved in Translation
0.1 1.9 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 1.9 REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC_C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.2 1.8 REACTOME_SIGNALING_BY_FGFR3_MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 1.6 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway