Motif ID: Cenpb
Z-value: 1.245
Transcription factors associated with Cenpb:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Cenpb | ENSMUSG00000068267.4 | Cenpb |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Cenpb | mm10_v2_chr2_-_131179985_131180092 | -0.28 | 3.8e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.7 | 20.1 | GO:0060598 | dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598) |
| 1.9 | 7.4 | GO:0060741 | prostate gland stromal morphogenesis(GO:0060741) |
| 1.6 | 3.2 | GO:0072076 | nephrogenic mesenchyme development(GO:0072076) |
| 1.6 | 4.8 | GO:0003219 | atrioventricular node development(GO:0003162) cardiac right ventricle formation(GO:0003219) |
| 1.6 | 4.8 | GO:0036388 | pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) DNA replication preinitiation complex assembly(GO:0071163) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299) |
| 1.5 | 4.4 | GO:0032474 | otolith morphogenesis(GO:0032474) |
| 1.3 | 7.9 | GO:0060242 | contact inhibition(GO:0060242) |
| 1.2 | 3.7 | GO:0051105 | regulation of DNA ligation(GO:0051105) positive regulation of DNA ligation(GO:0051106) |
| 1.2 | 5.8 | GO:0035262 | gonad morphogenesis(GO:0035262) |
| 1.1 | 5.5 | GO:0060266 | negative regulation of respiratory burst involved in inflammatory response(GO:0060266) |
| 1.0 | 3.1 | GO:1903630 | regulation of aminoacyl-tRNA ligase activity(GO:1903630) positive regulation of aminoacyl-tRNA ligase activity(GO:1903632) regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435) |
| 0.9 | 2.6 | GO:1904020 | regulation of G-protein coupled receptor internalization(GO:1904020) |
| 0.9 | 7.8 | GO:0090267 | positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267) |
| 0.8 | 9.9 | GO:0051601 | exocyst localization(GO:0051601) |
| 0.7 | 4.9 | GO:2001225 | cellular hypotonic response(GO:0071476) regulation of chloride transport(GO:2001225) |
| 0.6 | 5.3 | GO:0006975 | DNA damage induced protein phosphorylation(GO:0006975) |
| 0.5 | 1.6 | GO:0010940 | positive regulation of necrotic cell death(GO:0010940) |
| 0.5 | 1.1 | GO:0042726 | flavin-containing compound metabolic process(GO:0042726) |
| 0.5 | 3.6 | GO:1903715 | regulation of aerobic respiration(GO:1903715) |
| 0.5 | 5.1 | GO:1903298 | regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903297) negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903298) |
| 0.5 | 1.5 | GO:1903334 | positive regulation of protein folding(GO:1903334) |
| 0.5 | 1.9 | GO:0055099 | response to high density lipoprotein particle(GO:0055099) |
| 0.5 | 1.4 | GO:0098974 | postsynaptic actin cytoskeleton organization(GO:0098974) |
| 0.4 | 1.8 | GO:2000546 | positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546) |
| 0.4 | 2.6 | GO:1904936 | cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936) |
| 0.4 | 3.8 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 0.4 | 1.3 | GO:0001978 | regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback(GO:0001978) |
| 0.4 | 5.4 | GO:0021521 | ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573) |
| 0.4 | 1.6 | GO:0015744 | succinate transport(GO:0015744) |
| 0.4 | 1.4 | GO:0002035 | brain renin-angiotensin system(GO:0002035) positive regulation of arachidonic acid secretion(GO:0090238) |
| 0.4 | 1.1 | GO:0000720 | pyrimidine dimer repair by nucleotide-excision repair(GO:0000720) |
| 0.3 | 1.7 | GO:0014022 | neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007) |
| 0.3 | 1.0 | GO:0021972 | corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260) |
| 0.3 | 6.2 | GO:0022027 | interkinetic nuclear migration(GO:0022027) |
| 0.3 | 3.3 | GO:0021796 | cerebral cortex regionalization(GO:0021796) |
| 0.3 | 0.9 | GO:0018094 | protein polyglycylation(GO:0018094) |
| 0.3 | 17.0 | GO:0070303 | negative regulation of stress-activated MAPK cascade(GO:0032873) negative regulation of stress-activated protein kinase signaling cascade(GO:0070303) |
| 0.3 | 2.7 | GO:0048386 | positive regulation of retinoic acid receptor signaling pathway(GO:0048386) |
| 0.3 | 4.9 | GO:0045653 | negative regulation of megakaryocyte differentiation(GO:0045653) |
| 0.2 | 0.7 | GO:2001206 | positive regulation of osteoclast development(GO:2001206) |
| 0.2 | 0.9 | GO:1904751 | positive regulation of protein localization to nucleolus(GO:1904751) |
| 0.2 | 0.9 | GO:0044330 | canonical Wnt signaling pathway involved in positive regulation of wound healing(GO:0044330) lactic acid secretion(GO:0046722) regulation of metanephric cap mesenchymal cell proliferation(GO:0090095) positive regulation of metanephric cap mesenchymal cell proliferation(GO:0090096) |
| 0.2 | 0.7 | GO:0006407 | rRNA export from nucleus(GO:0006407) |
| 0.2 | 1.8 | GO:0044027 | hypermethylation of CpG island(GO:0044027) |
| 0.2 | 0.6 | GO:0006106 | fumarate metabolic process(GO:0006106) |
| 0.2 | 2.4 | GO:1902231 | positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231) |
| 0.2 | 1.7 | GO:0010764 | negative regulation of fibroblast migration(GO:0010764) negative regulation of cytokine production involved in inflammatory response(GO:1900016) |
| 0.2 | 0.6 | GO:0033615 | mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615) |
| 0.2 | 0.4 | GO:0072179 | nephric duct formation(GO:0072179) |
| 0.2 | 1.9 | GO:0006228 | UTP biosynthetic process(GO:0006228) |
| 0.2 | 1.0 | GO:0046600 | negative regulation of centriole replication(GO:0046600) |
| 0.2 | 0.8 | GO:0070459 | prolactin secretion(GO:0070459) |
| 0.2 | 0.5 | GO:2000620 | positive regulation of histone H4-K16 acetylation(GO:2000620) |
| 0.1 | 5.4 | GO:0030513 | positive regulation of BMP signaling pathway(GO:0030513) |
| 0.1 | 1.7 | GO:0031274 | positive regulation of pseudopodium assembly(GO:0031274) |
| 0.1 | 3.8 | GO:0097150 | neuronal stem cell population maintenance(GO:0097150) |
| 0.1 | 3.6 | GO:0044342 | type B pancreatic cell proliferation(GO:0044342) |
| 0.1 | 2.8 | GO:0042711 | maternal behavior(GO:0042711) |
| 0.1 | 2.8 | GO:0006999 | nuclear pore organization(GO:0006999) |
| 0.1 | 0.6 | GO:1903237 | negative regulation of leukocyte tethering or rolling(GO:1903237) |
| 0.1 | 1.3 | GO:0042135 | neurotransmitter catabolic process(GO:0042135) |
| 0.1 | 0.9 | GO:0044806 | G-quadruplex DNA unwinding(GO:0044806) |
| 0.1 | 4.5 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 0.1 | 1.5 | GO:0034244 | negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244) positive regulation of histone H3-K4 methylation(GO:0051571) |
| 0.1 | 4.5 | GO:0006879 | cellular iron ion homeostasis(GO:0006879) |
| 0.1 | 1.2 | GO:0036158 | outer dynein arm assembly(GO:0036158) |
| 0.1 | 0.5 | GO:0007603 | phototransduction, visible light(GO:0007603) |
| 0.1 | 0.3 | GO:0046133 | pyrimidine ribonucleoside catabolic process(GO:0046133) |
| 0.1 | 2.7 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.1 | 1.5 | GO:0030150 | protein import into mitochondrial matrix(GO:0030150) |
| 0.1 | 1.1 | GO:0006995 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
| 0.1 | 0.2 | GO:0002669 | positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913) |
| 0.1 | 1.5 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.1 | 1.1 | GO:0060052 | neurofilament cytoskeleton organization(GO:0060052) |
| 0.1 | 1.3 | GO:0043248 | proteasome assembly(GO:0043248) |
| 0.1 | 1.3 | GO:0016226 | iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163) |
| 0.1 | 0.2 | GO:0031038 | meiotic chromosome movement towards spindle pole(GO:0016344) myosin II filament organization(GO:0031038) regulation of myosin II filament organization(GO:0043519) regulation of bleb assembly(GO:1904170) |
| 0.1 | 0.7 | GO:0033089 | positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400) |
| 0.1 | 0.9 | GO:0071712 | ER-associated misfolded protein catabolic process(GO:0071712) |
| 0.1 | 0.5 | GO:0010815 | bradykinin catabolic process(GO:0010815) |
| 0.1 | 0.4 | GO:2001184 | regulation of interleukin-12 secretion(GO:2001182) positive regulation of interleukin-12 secretion(GO:2001184) |
| 0.1 | 4.0 | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) |
| 0.1 | 0.9 | GO:0046498 | S-adenosylhomocysteine metabolic process(GO:0046498) |
| 0.1 | 0.7 | GO:2000507 | positive regulation of energy homeostasis(GO:2000507) |
| 0.1 | 4.6 | GO:0007043 | cell-cell junction assembly(GO:0007043) |
| 0.1 | 2.0 | GO:0009299 | mRNA transcription(GO:0009299) |
| 0.1 | 0.9 | GO:2000251 | positive regulation of actin cytoskeleton reorganization(GO:2000251) |
| 0.1 | 0.6 | GO:0031936 | negative regulation of chromatin silencing(GO:0031936) |
| 0.1 | 3.0 | GO:0009060 | aerobic respiration(GO:0009060) |
| 0.0 | 0.5 | GO:1900119 | positive regulation of execution phase of apoptosis(GO:1900119) |
| 0.0 | 0.4 | GO:0048742 | regulation of skeletal muscle fiber development(GO:0048742) |
| 0.0 | 0.8 | GO:1902187 | negative regulation of viral release from host cell(GO:1902187) |
| 0.0 | 2.5 | GO:0005978 | glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250) |
| 0.0 | 1.5 | GO:0001947 | heart looping(GO:0001947) |
| 0.0 | 0.6 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
| 0.0 | 0.7 | GO:0010592 | positive regulation of lamellipodium assembly(GO:0010592) |
| 0.0 | 0.2 | GO:0090063 | microtubule anchoring at centrosome(GO:0034454) positive regulation of microtubule nucleation(GO:0090063) |
| 0.0 | 1.0 | GO:0051123 | RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123) |
| 0.0 | 0.5 | GO:0032515 | negative regulation of phosphoprotein phosphatase activity(GO:0032515) |
| 0.0 | 2.2 | GO:0033045 | regulation of sister chromatid segregation(GO:0033045) |
| 0.0 | 3.1 | GO:0042472 | inner ear morphogenesis(GO:0042472) |
| 0.0 | 0.4 | GO:0034143 | regulation of toll-like receptor 4 signaling pathway(GO:0034143) |
| 0.0 | 0.0 | GO:2001160 | regulation of histone H3-K79 methylation(GO:2001160) |
| 0.0 | 2.0 | GO:0006635 | fatty acid beta-oxidation(GO:0006635) |
| 0.0 | 1.1 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.0 | 1.2 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.0 | 1.8 | GO:0032543 | mitochondrial translation(GO:0032543) |
| 0.0 | 0.5 | GO:2000269 | regulation of fibroblast apoptotic process(GO:2000269) |
| 0.0 | 0.9 | GO:1903077 | negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376) |
| 0.0 | 1.9 | GO:0032886 | regulation of microtubule-based process(GO:0032886) |
| 0.0 | 0.2 | GO:0002315 | marginal zone B cell differentiation(GO:0002315) |
| 0.0 | 0.8 | GO:2001222 | regulation of neuron migration(GO:2001222) |
| 0.0 | 2.2 | GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway(GO:2001237) |
| 0.0 | 2.9 | GO:0043484 | regulation of RNA splicing(GO:0043484) |
| 0.0 | 1.9 | GO:0006487 | protein N-linked glycosylation(GO:0006487) |
| 0.0 | 0.7 | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184) |
| 0.0 | 0.1 | GO:0006663 | platelet activating factor biosynthetic process(GO:0006663) |
| 0.0 | 0.8 | GO:0030490 | maturation of SSU-rRNA(GO:0030490) |
| 0.0 | 1.1 | GO:0001578 | microtubule bundle formation(GO:0001578) |
| 0.0 | 2.1 | GO:0030308 | negative regulation of cell growth(GO:0030308) |
| 0.0 | 1.2 | GO:0045216 | cell-cell junction organization(GO:0045216) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 7.9 | GO:0071149 | TEAD-2-YAP complex(GO:0071149) |
| 1.6 | 4.8 | GO:0036387 | nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387) |
| 1.0 | 4.0 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 1.0 | 4.8 | GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex(GO:0002193) |
| 0.7 | 4.4 | GO:0097504 | Gemini of coiled bodies(GO:0097504) |
| 0.5 | 6.6 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.5 | 9.9 | GO:0000145 | exocyst(GO:0000145) |
| 0.4 | 1.5 | GO:0032021 | NELF complex(GO:0032021) |
| 0.3 | 2.0 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.3 | 1.3 | GO:0097361 | CIA complex(GO:0097361) |
| 0.3 | 3.8 | GO:0042555 | MCM complex(GO:0042555) |
| 0.2 | 2.1 | GO:0005883 | neurofilament(GO:0005883) |
| 0.2 | 3.1 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.2 | 3.7 | GO:0000800 | lateral element(GO:0000800) |
| 0.2 | 3.1 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 0.2 | 1.0 | GO:0070847 | core mediator complex(GO:0070847) |
| 0.1 | 4.9 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.1 | 2.7 | GO:0097470 | ribbon synapse(GO:0097470) |
| 0.1 | 1.2 | GO:0036157 | outer dynein arm(GO:0036157) |
| 0.1 | 1.6 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.1 | 10.4 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.1 | 2.4 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.1 | 1.1 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.1 | 2.8 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.1 | 0.7 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.1 | 1.6 | GO:0005686 | U2 snRNP(GO:0005686) |
| 0.1 | 0.6 | GO:0097025 | MPP7-DLG1-LIN7 complex(GO:0097025) |
| 0.1 | 0.9 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.1 | 1.8 | GO:0001741 | XY body(GO:0001741) |
| 0.1 | 1.5 | GO:0005839 | proteasome core complex(GO:0005839) |
| 0.1 | 4.2 | GO:0005657 | replication fork(GO:0005657) |
| 0.1 | 0.9 | GO:0036513 | Derlin-1 retrotranslocation complex(GO:0036513) |
| 0.1 | 1.1 | GO:0097225 | sperm midpiece(GO:0097225) |
| 0.1 | 1.4 | GO:0043189 | NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562) |
| 0.1 | 0.7 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.1 | 1.2 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.1 | 1.8 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.1 | 0.4 | GO:0090543 | Flemming body(GO:0090543) |
| 0.1 | 1.1 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 0.0 | 0.9 | GO:0033276 | transcription factor TFTC complex(GO:0033276) |
| 0.0 | 4.7 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
| 0.0 | 0.5 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 0.0 | 0.7 | GO:0097228 | sperm principal piece(GO:0097228) |
| 0.0 | 1.7 | GO:0035869 | ciliary transition zone(GO:0035869) |
| 0.0 | 0.6 | GO:0045239 | tricarboxylic acid cycle enzyme complex(GO:0045239) |
| 0.0 | 0.4 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
| 0.0 | 1.5 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 4.0 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 1.2 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 0.9 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.0 | 0.9 | GO:0005719 | nuclear euchromatin(GO:0005719) |
| 0.0 | 0.2 | GO:0043240 | Fanconi anaemia nuclear complex(GO:0043240) |
| 0.0 | 2.1 | GO:0005814 | centriole(GO:0005814) |
| 0.0 | 2.2 | GO:0030880 | RNA polymerase complex(GO:0030880) |
| 0.0 | 0.2 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.0 | 1.2 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 1.7 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.0 | 2.8 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.0 | 0.9 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.0 | 1.3 | GO:0030315 | T-tubule(GO:0030315) |
| 0.0 | 1.2 | GO:0016234 | inclusion body(GO:0016234) |
| 0.0 | 5.0 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 26.0 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.0 | 1.5 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.0 | 0.9 | GO:0097014 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 0.0 | 0.8 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 0.4 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 4.2 | GO:0035402 | histone kinase activity (H3-T11 specific)(GO:0035402) |
| 1.2 | 4.9 | GO:0004692 | cGMP-dependent protein kinase activity(GO:0004692) |
| 0.9 | 3.5 | GO:0046920 | alpha-(1->3)-fucosyltransferase activity(GO:0046920) |
| 0.6 | 1.9 | GO:0034437 | glycoprotein transporter activity(GO:0034437) |
| 0.6 | 10.8 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.6 | 1.8 | GO:0005105 | type 1 fibroblast growth factor receptor binding(GO:0005105) |
| 0.6 | 2.8 | GO:0004165 | dodecenoyl-CoA delta-isomerase activity(GO:0004165) |
| 0.5 | 1.6 | GO:0015140 | malate transmembrane transporter activity(GO:0015140) |
| 0.5 | 3.7 | GO:0000150 | recombinase activity(GO:0000150) |
| 0.5 | 1.4 | GO:0098973 | structural constituent of synapse(GO:0098918) structural constituent of postsynaptic actin cytoskeleton(GO:0098973) |
| 0.4 | 4.0 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.4 | 3.1 | GO:1990948 | ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948) |
| 0.4 | 5.5 | GO:0048273 | mitogen-activated protein kinase p38 binding(GO:0048273) |
| 0.4 | 1.3 | GO:0004936 | alpha-adrenergic receptor activity(GO:0004936) |
| 0.4 | 3.6 | GO:0035251 | UDP-glucosyltransferase activity(GO:0035251) |
| 0.4 | 2.2 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
| 0.4 | 1.1 | GO:0009881 | photoreceptor activity(GO:0009881) |
| 0.3 | 4.8 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.3 | 2.7 | GO:0016618 | hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267) |
| 0.3 | 3.2 | GO:0070700 | BMP receptor binding(GO:0070700) |
| 0.3 | 7.9 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.3 | 0.9 | GO:0070736 | protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) |
| 0.3 | 1.9 | GO:1901612 | phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612) |
| 0.2 | 3.1 | GO:0004576 | oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 0.2 | 1.8 | GO:0003886 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) |
| 0.2 | 1.5 | GO:0048101 | calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 0.2 | 1.5 | GO:0008242 | omega peptidase activity(GO:0008242) |
| 0.2 | 20.1 | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980) |
| 0.2 | 1.6 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
| 0.2 | 0.6 | GO:0004140 | dephospho-CoA kinase activity(GO:0004140) |
| 0.2 | 0.9 | GO:0004719 | protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719) |
| 0.2 | 1.4 | GO:0016863 | intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863) |
| 0.2 | 0.4 | GO:0004887 | thyroid hormone receptor activity(GO:0004887) |
| 0.2 | 2.4 | GO:0016805 | dipeptidase activity(GO:0016805) |
| 0.2 | 0.9 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
| 0.1 | 0.6 | GO:0031735 | CCR10 chemokine receptor binding(GO:0031735) |
| 0.1 | 4.8 | GO:0005112 | Notch binding(GO:0005112) |
| 0.1 | 2.6 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.1 | 1.7 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.1 | 1.0 | GO:0048495 | GTPase inhibitor activity(GO:0005095) Roundabout binding(GO:0048495) |
| 0.1 | 2.8 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.1 | 3.8 | GO:0017025 | TBP-class protein binding(GO:0017025) |
| 0.1 | 0.9 | GO:0043023 | ribosomal large subunit binding(GO:0043023) |
| 0.1 | 1.3 | GO:0043495 | protein anchor(GO:0043495) |
| 0.1 | 1.2 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.1 | 2.7 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.1 | 0.6 | GO:0097016 | L27 domain binding(GO:0097016) |
| 0.1 | 0.5 | GO:0047391 | alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391) |
| 0.1 | 0.7 | GO:0005451 | monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) |
| 0.1 | 0.3 | GO:0004126 | cytidine deaminase activity(GO:0004126) pyrroline-5-carboxylate reductase activity(GO:0004735) |
| 0.1 | 1.9 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.1 | 1.4 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.1 | 3.3 | GO:0003899 | DNA-directed RNA polymerase activity(GO:0003899) |
| 0.1 | 0.4 | GO:0005134 | interleukin-2 receptor binding(GO:0005134) |
| 0.1 | 1.5 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.1 | 1.2 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.1 | 1.1 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.1 | 1.5 | GO:0051087 | chaperone binding(GO:0051087) |
| 0.1 | 0.7 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
| 0.1 | 2.4 | GO:0004407 | histone deacetylase activity(GO:0004407) |
| 0.1 | 0.3 | GO:0019841 | retinol binding(GO:0019841) |
| 0.1 | 0.9 | GO:1904264 | ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264) |
| 0.1 | 2.0 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.1 | 2.0 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.1 | 1.1 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.0 | 6.3 | GO:0001046 | core promoter sequence-specific DNA binding(GO:0001046) |
| 0.0 | 1.2 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.0 | 0.4 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.0 | 3.6 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
| 0.0 | 1.0 | GO:0098811 | transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811) |
| 0.0 | 0.9 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.0 | 0.7 | GO:0043236 | laminin binding(GO:0043236) |
| 0.0 | 0.5 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.0 | 0.9 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 0.4 | GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) |
| 0.0 | 3.2 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 0.8 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.0 | 4.4 | GO:0003682 | chromatin binding(GO:0003682) |
| 0.0 | 1.1 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
| 0.0 | 1.9 | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981) |
| 0.0 | 0.1 | GO:0004142 | diacylglycerol cholinephosphotransferase activity(GO:0004142) |
| 0.0 | 10.2 | GO:0043565 | sequence-specific DNA binding(GO:0043565) |
| 0.0 | 0.5 | GO:0030145 | manganese ion binding(GO:0030145) |
| 0.0 | 0.5 | GO:0016836 | hydro-lyase activity(GO:0016836) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 4.2 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.4 | 19.8 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.3 | 15.9 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.3 | 3.2 | PID_ALK2_PATHWAY | ALK2 signaling events |
| 0.1 | 5.2 | PID_AURORA_A_PATHWAY | Aurora A signaling |
| 0.1 | 5.9 | PID_P38_ALPHA_BETA_PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.1 | 4.8 | PID_ATR_PATHWAY | ATR signaling pathway |
| 0.1 | 2.5 | PID_INSULIN_GLUCOSE_PATHWAY | Insulin-mediated glucose transport |
| 0.1 | 2.0 | PID_PDGFRA_PATHWAY | PDGFR-alpha signaling pathway |
| 0.1 | 1.1 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
| 0.1 | 4.5 | PID_ERBB1_INTERNALIZATION_PATHWAY | Internalization of ErbB1 |
| 0.1 | 0.9 | PID_MYC_PATHWAY | C-MYC pathway |
| 0.0 | 3.1 | PID_P53_REGULATION_PATHWAY | p53 pathway |
| 0.0 | 0.5 | PID_RHODOPSIN_PATHWAY | Visual signal transduction: Rods |
| 0.0 | 1.8 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 1.0 | PID_GLYPICAN_1PATHWAY | Glypican 1 network |
| 0.0 | 4.1 | WNT_SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 1.7 | PID_ECADHERIN_NASCENT_AJ_PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 0.7 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 2.0 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.0 | 1.3 | PID_FGF_PATHWAY | FGF signaling pathway |
| 0.0 | 1.0 | PID_NFAT_TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 0.2 | PID_NCADHERIN_PATHWAY | N-cadherin signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 8.6 | REACTOME_UNWINDING_OF_DNA | Genes involved in Unwinding of DNA |
| 0.4 | 4.2 | REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.4 | 4.4 | REACTOME_SIGNALING_BY_EGFR_IN_CANCER | Genes involved in Signaling by EGFR in Cancer |
| 0.4 | 7.8 | REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| 0.3 | 7.9 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.3 | 4.9 | REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.2 | 3.7 | REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.2 | 1.8 | REACTOME_SIGNALING_BY_FGFR3_MUTANTS | Genes involved in Signaling by FGFR3 mutants |
| 0.2 | 5.9 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.2 | 2.8 | REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.2 | 4.0 | REACTOME_SULFUR_AMINO_ACID_METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.1 | 1.9 | REACTOME_HDL_MEDIATED_LIPID_TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.1 | 4.9 | REACTOME_PACKAGING_OF_TELOMERE_ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.1 | 7.2 | REACTOME_METABOLISM_OF_NON_CODING_RNA | Genes involved in Metabolism of non-coding RNA |
| 0.1 | 0.5 | REACTOME_OLFACTORY_SIGNALING_PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.1 | 1.3 | REACTOME_AMINE_LIGAND_BINDING_RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.1 | 5.3 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 1.0 | REACTOME_ACTIVATION_OF_RAC | Genes involved in Activation of Rac |
| 0.1 | 1.1 | REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.1 | 7.7 | REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.1 | 0.7 | REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_BY_THE_EXON_JUNCTION_COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |
| 0.1 | 2.6 | REACTOME_TRANSLATION | Genes involved in Translation |
| 0.0 | 1.5 | REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.0 | 1.4 | REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC | Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC |
| 0.0 | 0.6 | REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.0 | 1.6 | REACTOME_MRNA_SPLICING_MINOR_PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 0.0 | 0.6 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.0 | 3.6 | REACTOME_MRNA_SPLICING | Genes involved in mRNA Splicing |
| 0.0 | 1.9 | REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC_C | Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C |
| 0.0 | 0.9 | REACTOME_CYCLIN_E_ASSOCIATED_EVENTS_DURING_G1_S_TRANSITION_ | Genes involved in Cyclin E associated events during G1/S transition |
| 0.0 | 0.9 | REACTOME_STRIATED_MUSCLE_CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 0.4 | REACTOME_DSCAM_INTERACTIONS | Genes involved in DSCAM interactions |
| 0.0 | 0.6 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 1.2 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 0.9 | REACTOME_PYRUVATE_METABOLISM_AND_CITRIC_ACID_TCA_CYCLE | Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle |
| 0.0 | 0.2 | REACTOME_FANCONI_ANEMIA_PATHWAY | Genes involved in Fanconi Anemia pathway |
| 0.0 | 0.9 | REACTOME_GLUCOSE_METABOLISM | Genes involved in Glucose metabolism |
