Motif ID: Chd1_Pml

Z-value: 4.204

Transcription factors associated with Chd1_Pml:

Gene SymbolEntrez IDGene Name
Chd1 ENSMUSG00000023852.7 Chd1
Pml ENSMUSG00000036986.10 Pml

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pmlmm10_v2_chr9_-_58249660_58249672-0.431.2e-03Click!
Chd1mm10_v2_chr17_+_15704963_15704994-0.123.9e-01Click!


Activity profile for motif Chd1_Pml.

activity profile for motif Chd1_Pml


Sorted Z-values histogram for motif Chd1_Pml

Sorted Z-values for motif Chd1_Pml



Network of associatons between targets according to the STRING database.



First level regulatory network of Chd1_Pml

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_39472825 44.876 ENSMUST00000168810.2
ENSMUST00000173780.1
ENSMUST00000166968.2
 Nrg3


neuregulin 3


chr15_-_66286224 44.061 ENSMUST00000070256.7
 Kcnq3
potassium voltage-gated channel, subfamily Q, member 3
chr6_+_99692679 38.995 ENSMUST00000101122.1
 Gpr27
G protein-coupled receptor 27
chrX_+_69360294 38.427 ENSMUST00000033532.6
 Aff2
AF4/FMR2 family, member 2
chr10_-_43174521 38.046 ENSMUST00000040275.7
 Sobp
sine oculis-binding protein homolog (Drosophila)
chr7_+_123982799 35.835 ENSMUST00000106437.1
 Hs3st4
heparan sulfate (glucosamine) 3-O-sulfotransferase 4
chr11_-_6065737 33.661 ENSMUST00000002817.5
ENSMUST00000109813.2
ENSMUST00000090443.3
 Camk2b


calcium/calmodulin-dependent protein kinase II, beta


chr9_-_98033181 32.001 ENSMUST00000035027.6
 Clstn2
calsyntenin 2
chr14_-_102982630 31.341 ENSMUST00000184744.1
 KCTD12
mmu-mir-5130
chr15_+_89499598 30.914 ENSMUST00000109309.1
 Shank3
SH3/ankyrin domain gene 3
chr11_-_6065538 29.709 ENSMUST00000101585.3
ENSMUST00000066431.7
ENSMUST00000109815.2
ENSMUST00000109812.2
ENSMUST00000101586.2
ENSMUST00000093355.5
ENSMUST00000019133.4
 Camk2b






calcium/calmodulin-dependent protein kinase II, beta






chr1_-_56972437 29.643 ENSMUST00000042857.7
 Satb2
special AT-rich sequence binding protein 2
chr4_-_46991842 29.022 ENSMUST00000107749.2
 Gabbr2
gamma-aminobutyric acid (GABA) B receptor, 2
chr16_-_67620880 28.698 ENSMUST00000114292.1
ENSMUST00000120898.1
 Cadm2

cell adhesion molecule 2

chr18_-_58209926 28.564 ENSMUST00000025497.6
 Fbn2
fibrillin 2
chr1_-_3671498 28.395 ENSMUST00000070533.4
 Xkr4
X Kell blood group precursor related family member 4
chr7_+_57591147 27.058 ENSMUST00000039697.7
 Gabrb3
gamma-aminobutyric acid (GABA) A receptor, subunit beta 3
chr1_-_56971762 26.831 ENSMUST00000114415.3
 Satb2
special AT-rich sequence binding protein 2
chr2_-_163918683 26.811 ENSMUST00000044734.2
 Rims4
regulating synaptic membrane exocytosis 4
chr4_-_123664725 26.562 ENSMUST00000147030.1
 Macf1
microtubule-actin crosslinking factor 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,065 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 148.6 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.0 135.5 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
6.9 110.8 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
6.1 109.3 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
6.3 94.0 GO:0060081 membrane hyperpolarization(GO:0060081)
12.6 75.6 GO:0042276 error-prone translesion synthesis(GO:0042276)
2.7 73.4 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
21.2 63.6 GO:0002030 inhibitory G-protein coupled receptor phosphorylation(GO:0002030)
4.1 61.1 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
4.7 56.6 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
3.5 56.6 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.8 55.1 GO:0035308 negative regulation of protein dephosphorylation(GO:0035308)
2.3 54.1 GO:2000463 positive regulation of excitatory postsynaptic potential(GO:2000463)
1.0 53.5 GO:0016579 protein deubiquitination(GO:0016579)
5.1 51.1 GO:0046959 habituation(GO:0046959)
3.3 49.2 GO:0014041 regulation of neuron maturation(GO:0014041)
16.0 48.0 GO:0060596 mammary placode formation(GO:0060596)
3.2 48.0 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
15.7 47.1 GO:1900738 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
1.8 45.3 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 347 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 806.3 GO:0016021 integral component of membrane(GO:0016021)
1.9 408.4 GO:0045211 postsynaptic membrane(GO:0045211)
0.6 292.4 GO:0005768 endosome(GO:0005768)
4.5 185.2 GO:0032809 neuronal cell body membrane(GO:0032809)
2.0 160.2 GO:0005905 clathrin-coated pit(GO:0005905)
1.0 156.4 GO:0014069 postsynaptic density(GO:0014069)
3.2 141.7 GO:0048786 presynaptic active zone(GO:0048786)
0.7 138.3 GO:0000139 Golgi membrane(GO:0000139)
2.2 135.3 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
3.1 130.0 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
3.7 119.7 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
3.6 104.5 GO:0033268 node of Ranvier(GO:0033268)
1.5 101.0 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.8 81.1 GO:0055037 recycling endosome(GO:0055037)
12.9 77.2 GO:0016035 zeta DNA polymerase complex(GO:0016035)
1.6 77.2 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
1.9 75.1 GO:0042734 presynaptic membrane(GO:0042734)
5.7 73.5 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
1.6 73.3 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
3.7 70.4 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 605 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 338.5 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
1.1 155.2 GO:0017137 Rab GTPase binding(GO:0017137)
2.7 139.8 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
1.4 137.0 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.6 106.0 GO:0008017 microtubule binding(GO:0008017)
2.0 103.5 GO:0030507 spectrin binding(GO:0030507)
0.6 102.1 GO:0005096 GTPase activator activity(GO:0005096)
3.1 81.4 GO:0017075 syntaxin-1 binding(GO:0017075)
1.0 81.4 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
3.3 72.5 GO:0043274 phospholipase binding(GO:0043274)
1.8 71.9 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
4.3 69.0 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
1.5 67.0 GO:0046875 ephrin receptor binding(GO:0046875)
3.4 61.8 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
5.2 57.0 GO:0002151 G-quadruplex RNA binding(GO:0002151)
8.1 56.4 GO:0099609 microtubule lateral binding(GO:0099609)
2.8 55.7 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
5.0 54.6 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.9 53.9 GO:0048365 Rac GTPase binding(GO:0048365)
5.9 52.8 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 103 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.5 202.3 PID_REELIN_PATHWAY Reelin signaling pathway
2.8 156.8 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
7.4 125.5 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.8 97.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
2.2 90.3 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway
1.5 85.6 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
1.4 77.6 PID_LKB1_PATHWAY LKB1 signaling events
2.7 63.0 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
3.3 58.6 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.9 51.1 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
1.1 46.8 PID_SHP2_PATHWAY SHP2 signaling
2.9 44.0 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
1.5 38.1 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.8 34.2 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
1.1 31.9 PID_ARF_3PATHWAY Arf1 pathway
1.4 30.3 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
1.5 27.6 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.9 25.9 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
2.1 22.6 PID_S1P_S1P4_PATHWAY S1P4 pathway
1.2 22.3 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 177 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.9 203.8 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
2.6 94.1 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
2.8 89.0 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
6.9 82.7 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
3.4 81.2 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
1.1 75.4 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
2.5 73.9 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
5.4 70.4 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
5.4 70.2 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
1.9 67.6 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
2.9 66.8 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
2.5 64.0 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
2.7 60.5 REACTOME_ARMS_MEDIATED_ACTIVATION Genes involved in ARMS-mediated activation
1.5 58.0 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
2.4 57.6 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
3.6 56.9 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
2.7 56.8 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
2.7 54.2 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
1.1 53.8 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
1.5 51.5 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions