Motif ID: Clock

Z-value: 0.408


Transcription factors associated with Clock:

Gene SymbolEntrez IDGene Name
Clock ENSMUSG00000029238.8 Clock

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Clockmm10_v2_chr5_-_76304474_76304548-0.047.7e-01Click!


Activity profile for motif Clock.

activity profile for motif Clock


Sorted Z-values histogram for motif Clock

Sorted Z-values for motif Clock



Network of associatons between targets according to the STRING database.



First level regulatory network of Clock

PNG image of the network

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Top targets:


Showing 1 to 20 of 167 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_164769892 1.643 ENSMUST00000088248.6
ENSMUST00000001439.6
 Ube2c

ubiquitin-conjugating enzyme E2C

chr7_-_144939823 1.545 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr5_+_139543889 1.477 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr14_-_20181773 1.230 ENSMUST00000024011.8
 Kcnk5
potassium channel, subfamily K, member 5
chr1_-_75219245 1.146 ENSMUST00000079464.6
 Tuba4a
tubulin, alpha 4A
chr5_-_22344690 1.142 ENSMUST00000062372.7
ENSMUST00000161356.1
 Reln

reelin

chr11_-_100759942 0.965 ENSMUST00000107363.2
 Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr6_-_49214954 0.932 ENSMUST00000031838.7
 Igf2bp3
insulin-like growth factor 2 mRNA binding protein 3
chr5_+_93093428 0.833 ENSMUST00000074733.7
 Sept11
septin 11
chr11_-_100759740 0.832 ENSMUST00000107361.2
 Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr12_+_59131473 0.817 ENSMUST00000177162.1
 Ctage5
CTAGE family, member 5
chr1_-_82291370 0.782 ENSMUST00000069799.2
 Irs1
insulin receptor substrate 1
chr4_-_97778042 0.778 ENSMUST00000146447.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr12_+_59131286 0.761 ENSMUST00000176464.1
ENSMUST00000170992.2
ENSMUST00000176322.1
 Ctage5


CTAGE family, member 5


chr17_-_35000848 0.736 ENSMUST00000166828.3
 D17H6S56E-5
DNA segment, Chr 17, human D6S56E 5
chr2_+_160645881 0.721 ENSMUST00000109468.2
 Top1
topoisomerase (DNA) I
chr1_-_12991109 0.714 ENSMUST00000115403.2
ENSMUST00000115402.1
 Slco5a1

solute carrier organic anion transporter family, member 5A1

chr6_-_47813512 0.714 ENSMUST00000077290.7
 Pdia4
protein disulfide isomerase associated 4
chr9_-_106891401 0.714 ENSMUST00000069036.7
 Manf
mesencephalic astrocyte-derived neurotrophic factor
chr11_+_101316917 0.699 ENSMUST00000151385.1
 Psme3
proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 1.6 GO:0010993 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.0 1.6 GO:2000045 regulation of G1/S transition of mitotic cell cycle(GO:2000045)
0.2 1.5 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.2 1.5 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.2 1.3 GO:0006344 maintenance of chromatin silencing(GO:0006344)
0.1 1.2 GO:0030322 stabilization of membrane potential(GO:0030322)
0.3 1.1 GO:0097477 lateral motor column neuron migration(GO:0097477)
0.3 0.9 GO:1903334 positive regulation of protein folding(GO:1903334)
0.3 0.9 GO:0002014 vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure(GO:0002014)
0.2 0.8 GO:0090273 regulation of somatostatin secretion(GO:0090273)
0.1 0.7 GO:0006543 glutamine catabolic process(GO:0006543)
0.1 0.7 GO:0006265 DNA topological change(GO:0006265)
0.1 0.7 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.1 0.7 GO:0033690 positive regulation of osteoblast proliferation(GO:0033690)
0.0 0.7 GO:0033572 transferrin transport(GO:0033572)
0.0 0.7 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 0.7 GO:0001913 T cell mediated cytotoxicity(GO:0001913)
0.1 0.6 GO:0060535 trachea cartilage morphogenesis(GO:0060535)
0.1 0.6 GO:0046864 retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865) alveolar primary septum development(GO:0061143)
0.1 0.6 GO:0048254 snoRNA localization(GO:0048254)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.6 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 1.5 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.3 1.2 GO:0008537 proteasome activator complex(GO:0008537)
0.3 0.8 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.8 GO:0009925 basal plasma membrane(GO:0009925)
0.2 0.7 GO:0001651 dense fibrillar component(GO:0001651)
0.2 0.7 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.1 0.7 GO:0000125 PCAF complex(GO:0000125)
0.1 0.7 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.1 0.7 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 0.5 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.1 0.5 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.5 GO:0016592 mediator complex(GO:0016592)
0.1 0.4 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 0.4 GO:0090543 Flemming body(GO:0090543)
0.1 0.3 GO:0070552 BRISC complex(GO:0070552)
0.1 0.3 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 0.3 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 0.3 GO:0032797 SMN complex(GO:0032797)
0.0 0.3 GO:0030127 COPII vesicle coat(GO:0030127)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.8 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 1.8 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.1 1.6 GO:0070064 proline-rich region binding(GO:0070064)
0.0 1.3 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 1.2 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 1.2 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.2 1.1 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.1 1.0 GO:0015037 peptide disulfide oxidoreductase activity(GO:0015037)
0.0 0.9 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.1 0.8 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.2 0.7 GO:0004998 transferrin receptor activity(GO:0004998)
0.2 0.7 GO:0097100 supercoiled DNA binding(GO:0097100)
0.1 0.7 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.1 0.7 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 0.7 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.7 GO:0017025 TBP-class protein binding(GO:0017025)
0.1 0.6 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.1 0.6 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.0 0.6 GO:0051183 vitamin transporter activity(GO:0051183)
0.0 0.6 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)

Gene overrepresentation in C2:CP category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.5 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.9 PID_MYC_PATHWAY C-MYC pathway
0.0 0.9 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.9 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 0.8 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.0 0.7 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.7 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.7 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.7 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 0.3 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.2 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.1 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.8 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 1.6 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1 1.5 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 1.1 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 1.1 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.8 REACTOME_SOS_MEDIATED_SIGNALLING Genes involved in SOS-mediated signalling
0.0 0.8 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.7 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.7 REACTOME_TRANSFERRIN_ENDOCYTOSIS_AND_RECYCLING Genes involved in Transferrin endocytosis and recycling
0.0 0.6 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 0.6 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.5 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.4 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.4 REACTOME_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Neurotransmitter Release Cycle
0.0 0.3 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.2 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway