Motif ID: Creb1

Z-value: 1.500


Transcription factors associated with Creb1:

Gene SymbolEntrez IDGene Name
Creb1 ENSMUSG00000025958.8 Creb1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Creb1mm10_v2_chr1_+_64532790_645328150.221.1e-01Click!


Activity profile for motif Creb1.

activity profile for motif Creb1


Sorted Z-values histogram for motif Creb1

Sorted Z-values for motif Creb1



Network of associatons between targets according to the STRING database.



First level regulatory network of Creb1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_6084983 12.241 ENSMUST00000025704.2
 Cdca5
cell division cycle associated 5
chr15_-_76710486 7.683 ENSMUST00000036852.7
 Recql4
RecQ protein-like 4
chr7_-_38107490 7.448 ENSMUST00000108023.3
 Ccne1
cyclin E1
chr9_+_122951051 7.440 ENSMUST00000040717.5
 Kif15
kinesin family member 15
chr2_+_156840966 7.400 ENSMUST00000109564.1
 Tgif2
TGFB-induced factor homeobox 2
chr10_+_121033960 7.098 ENSMUST00000020439.4
ENSMUST00000175867.1
 Wif1

Wnt inhibitory factor 1

chr6_+_113531675 7.011 ENSMUST00000036340.5
ENSMUST00000101051.2
 Fancd2

Fanconi anemia, complementation group D2

chr12_-_4907705 6.727 ENSMUST00000020962.5
 Ubxn2a
UBX domain protein 2A
chr4_+_105157339 6.693 ENSMUST00000064139.7
 Ppap2b
phosphatidic acid phosphatase type 2B
chr3_+_135212557 6.648 ENSMUST00000062893.7
 Cenpe
centromere protein E
chr8_+_57511833 6.517 ENSMUST00000067925.6
 Hmgb2
high mobility group box 2
chr11_+_43528759 6.387 ENSMUST00000050574.6
 Ccnjl
cyclin J-like
chr2_+_119047116 6.057 ENSMUST00000152380.1
ENSMUST00000099542.2
 Casc5

cancer susceptibility candidate 5

chr4_-_58553553 5.992 ENSMUST00000107575.2
ENSMUST00000107574.1
ENSMUST00000147354.1
 Lpar1


lysophosphatidic acid receptor 1


chr13_-_29984219 5.906 ENSMUST00000146092.1
 E2f3
E2F transcription factor 3
chr7_-_118533298 5.482 ENSMUST00000098090.3
ENSMUST00000032887.3
 Coq7

demethyl-Q 7

chr4_-_58553311 5.469 ENSMUST00000107571.1
ENSMUST00000055018.4
 Lpar1

lysophosphatidic acid receptor 1

chr14_-_103843685 4.946 ENSMUST00000172237.1
 Ednrb
endothelin receptor type B
chr12_-_4907229 4.919 ENSMUST00000142867.1
 Ubxn2a
UBX domain protein 2A
chr7_-_137314394 4.860 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
 Ebf3



early B cell factor 3




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 155 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.6 14.5 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
4.1 12.2 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
1.0 11.6 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.4 11.1 GO:0030488 tRNA methylation(GO:0030488)
0.8 9.6 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 9.6 GO:0007018 microtubule-based movement(GO:0007018)
0.2 8.8 GO:0006270 DNA replication initiation(GO:0006270)
1.2 8.5 GO:1901970 positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101)
1.3 7.7 GO:0045875 DNA strand renaturation(GO:0000733) negative regulation of sister chromatid cohesion(GO:0045875)
1.1 7.4 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.7 7.4 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.1 7.2 GO:0007098 centrosome cycle(GO:0007098)
0.1 7.1 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.9 6.5 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
1.5 6.0 GO:0010847 regulation of chromatin assembly(GO:0010847)
0.6 5.6 GO:1904153 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
1.4 5.5 GO:0001306 age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.3 5.5 GO:0015693 magnesium ion transport(GO:0015693)
1.8 5.4 GO:0072554 arterial endothelial cell fate commitment(GO:0060844) blood vessel endothelial cell fate commitment(GO:0060846) endothelial cell fate specification(GO:0060847) Notch signaling pathway involved in arterial endothelial cell fate commitment(GO:0060853) blood vessel lumenization(GO:0072554) blood vessel endothelial cell fate specification(GO:0097101) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) positive regulation of heart induction(GO:1901321) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066)
1.3 5.4 GO:0072365 regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072365)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 102 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 18.1 GO:0005871 kinesin complex(GO:0005871)
0.1 14.5 GO:0043198 dendritic shaft(GO:0043198)
1.7 12.2 GO:0008278 cohesin complex(GO:0008278)
0.1 12.1 GO:0000793 condensed chromosome(GO:0000793)
0.2 11.4 GO:0005801 cis-Golgi network(GO:0005801)
0.1 10.3 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 10.2 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 7.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 7.3 GO:0097546 ciliary base(GO:0097546)
0.5 6.6 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778) mitotic spindle midzone(GO:1990023)
0.9 6.3 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.1 6.3 GO:0000776 kinetochore(GO:0000776)
0.1 6.2 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 6.0 GO:0005643 nuclear pore(GO:0005643)
0.0 5.8 GO:0000781 chromosome, telomeric region(GO:0000781)
0.0 5.7 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 5.5 GO:0005811 lipid particle(GO:0005811)
1.1 5.4 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.4 5.3 GO:0030127 COPII vesicle coat(GO:0030127)
0.9 5.1 GO:0005663 DNA replication factor C complex(GO:0005663)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 117 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 14.5 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.4 11.6 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.2 10.4 GO:0003777 microtubule motor activity(GO:0003777)
1.3 10.3 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.3 9.2 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.2 8.8 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 8.8 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 7.8 GO:0003682 chromatin binding(GO:0003682)
1.5 7.7 GO:0000405 bubble DNA binding(GO:0000405)
0.2 7.7 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.2 7.7 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.1 7.7 GO:0004497 monooxygenase activity(GO:0004497)
0.0 7.2 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.2 7.1 GO:0017147 Wnt-protein binding(GO:0017147)
0.1 6.9 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
1.3 6.6 GO:0043515 kinetochore binding(GO:0043515)
1.1 6.5 GO:0050786 RAGE receptor binding(GO:0050786)
0.3 6.3 GO:0017160 Ral GTPase binding(GO:0017160)
0.3 6.2 GO:0070182 DNA polymerase binding(GO:0070182)
0.1 5.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 18.4 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.2 13.9 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.2 12.4 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.2 12.3 PID_E2F_PATHWAY E2F transcription factor network
0.5 7.4 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2 7.1 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 6.6 PID_PLK1_PATHWAY PLK1 signaling events
0.1 5.6 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.2 5.1 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 5.1 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 5.1 PID_FAS_PATHWAY FAS (CD95) signaling pathway
0.1 4.9 PID_ENDOTHELIN_PATHWAY Endothelins
0.1 3.0 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 2.6 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 2.3 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.3 2.1 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.2 1.7 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 1.6 PID_AVB3_INTEGRIN_PATHWAY Integrins in angiogenesis
0.1 1.3 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 1.2 PID_CD40_PATHWAY CD40/CD40L signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 17.1 REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
1.2 12.4 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.2 10.9 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.3 10.4 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.6 9.3 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.3 7.4 REACTOME_KINESINS Genes involved in Kinesins
0.4 6.5 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.4 6.3 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.5 5.9 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.3 5.4 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 4.7 REACTOME_TRANSPORT_OF_MATURE_MRNA_DERIVED_FROM_AN_INTRONLESS_TRANSCRIPT Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.1 4.6 REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE Genes involved in Late Phase of HIV Life Cycle
0.2 4.5 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_2_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.1 4.3 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 4.0 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 3.9 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.0 3.2 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 3.1 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.2 3.0 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events
0.2 2.9 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway