Motif ID: Creb3

Z-value: 0.730


Transcription factors associated with Creb3:

Gene SymbolEntrez IDGene Name
Creb3 ENSMUSG00000028466.9 Creb3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Creb3mm10_v2_chr4_+_43562672_43562947-0.542.4e-05Click!


Activity profile for motif Creb3.

activity profile for motif Creb3


Sorted Z-values histogram for motif Creb3

Sorted Z-values for motif Creb3



Network of associatons between targets according to the STRING database.



First level regulatory network of Creb3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_60893430 9.074 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr7_-_45092130 8.264 ENSMUST00000148175.1
 Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr7_-_45091713 8.033 ENSMUST00000141576.1
 Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr2_-_71546745 7.820 ENSMUST00000024159.6
 Dlx2
distal-less homeobox 2
chr2_-_105399286 7.036 ENSMUST00000006128.6
 Rcn1
reticulocalbin 1
chr14_-_79301623 6.893 ENSMUST00000022595.7
 Rgcc
regulator of cell cycle
chr15_+_79516396 6.591 ENSMUST00000010974.7
 Kdelr3
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
chr3_-_36571952 6.064 ENSMUST00000029270.3
 Ccna2
cyclin A2
chr4_-_117182623 5.779 ENSMUST00000065896.2
 Kif2c
kinesin family member 2C
chr5_-_135251209 5.658 ENSMUST00000062572.2
 Fzd9
frizzled homolog 9 (Drosophila)
chr11_-_94653964 5.121 ENSMUST00000039949.4
 Eme1
essential meiotic endonuclease 1 homolog 1 (S. pombe)
chr2_-_150668198 4.666 ENSMUST00000028944.3
 Acss1
acyl-CoA synthetase short-chain family member 1
chr7_-_144939823 4.089 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr18_+_84720019 4.085 ENSMUST00000161429.1
ENSMUST00000052501.1
 Fam69c

family with sequence similarity 69, member C

chr10_+_41519493 4.082 ENSMUST00000019962.8
 Cd164
CD164 antigen
chr7_-_45092198 4.074 ENSMUST00000140449.1
ENSMUST00000117546.1
ENSMUST00000019683.3
 Rcn3


reticulocalbin 3, EF-hand calcium binding domain


chr2_+_119112793 3.789 ENSMUST00000140939.1
ENSMUST00000028795.3
 Rad51

RAD51 homolog

chr4_+_47474652 3.729 ENSMUST00000065678.5
ENSMUST00000137461.1
ENSMUST00000125622.1
 Sec61b


Sec61 beta subunit


chr4_+_3938888 3.633 ENSMUST00000121110.1
ENSMUST00000108386.1
ENSMUST00000149544.1
 Chchd7


coiled-coil-helix-coiled-coil-helix domain containing 7


chr7_-_25250720 3.551 ENSMUST00000116343.2
ENSMUST00000045847.8
 Erf

Ets2 repressor factor


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 111 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 9.1 GO:0007530 sex determination(GO:0007530)
2.6 7.8 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
1.1 7.4 GO:0006621 protein retention in ER lumen(GO:0006621)
1.7 6.9 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.1 6.1 GO:0048146 positive regulation of fibroblast proliferation(GO:0048146)
1.2 5.8 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
1.9 5.7 GO:1990523 bone regeneration(GO:1990523)
0.6 5.3 GO:1904153 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
1.0 5.1 GO:0072429 response to intra-S DNA damage checkpoint signaling(GO:0072429)
0.1 4.8 GO:0032526 response to retinoic acid(GO:0032526)
1.6 4.7 GO:0006083 acetate metabolic process(GO:0006083)
0.8 4.6 GO:0032196 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196)
0.6 4.1 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.3 4.0 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
1.3 3.8 GO:0051105 regulation of DNA ligation(GO:0051105) positive regulation of DNA ligation(GO:0051106)
1.2 3.7 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.4 3.7 GO:1903298 regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903297) negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903298)
0.7 3.6 GO:0010668 ectodermal cell differentiation(GO:0010668)
1.2 3.5 GO:0070476 rRNA (guanine-N7)-methylation(GO:0070476)
0.3 3.5 GO:0007135 meiosis II(GO:0007135) positive regulation of ubiquitin protein ligase activity(GO:1904668)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 6.1 GO:0001940 male pronucleus(GO:0001940)
0.2 5.8 GO:0035371 microtubule plus-end(GO:0035371)
0.2 5.7 GO:0031527 filopodium membrane(GO:0031527)
1.0 5.1 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.3 4.4 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 4.2 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 4.0 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 3.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 3.8 GO:0000800 lateral element(GO:0000800)
1.2 3.7 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.0 3.6 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 3.4 GO:0030018 Z disc(GO:0030018)
0.0 3.0 GO:0005844 polysome(GO:0005844)
0.0 3.0 GO:0005759 mitochondrial matrix(GO:0005759)
0.3 2.6 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.1 2.6 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 2.5 GO:0016235 aggresome(GO:0016235)
0.0 2.5 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.2 2.0 GO:0097413 Lewy body(GO:0097413)
0.4 1.9 GO:0043527 tRNA methyltransferase complex(GO:0043527)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 86 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 20.9 GO:0005509 calcium ion binding(GO:0005509)
0.1 11.8 GO:0003727 single-stranded RNA binding(GO:0003727)
0.3 9.7 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.2 9.2 GO:0097472 cyclin-dependent protein kinase activity(GO:0097472)
0.0 7.8 GO:0003714 transcription corepressor activity(GO:0003714)
1.9 7.4 GO:0046923 ER retention sequence binding(GO:0046923)
0.1 7.0 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.2 6.8 GO:0070412 R-SMAD binding(GO:0070412)
0.3 5.8 GO:0051010 microtubule plus-end binding(GO:0051010)
0.2 5.7 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.2 5.3 GO:0005109 frizzled binding(GO:0005109)
0.6 5.1 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.0 5.0 GO:0003735 structural constituent of ribosome(GO:0003735)
1.6 4.7 GO:0003987 acetate-CoA ligase activity(GO:0003987)
1.2 4.6 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.8 3.8 GO:0000150 recombinase activity(GO:0000150)
0.1 3.8 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.9 3.7 GO:0048408 epidermal growth factor binding(GO:0048408)
0.0 3.5 GO:0008276 protein methyltransferase activity(GO:0008276)
0.4 3.4 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 10.2 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 5.8 PID_AURORA_B_PATHWAY Aurora B signaling
0.2 5.7 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.2 5.5 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.1 4.6 PID_BARD1_PATHWAY BARD1 signaling events
0.0 3.7 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 3.0 ST_FAS_SIGNALING_PATHWAY Fas Signaling Pathway
0.1 2.8 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.2 2.1 ST_JAK_STAT_PATHWAY Jak-STAT Pathway
0.1 1.7 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 1.3 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 1.3 PID_PLK1_PATHWAY PLK1 signaling events
0.1 1.1 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 1.1 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.0 1.1 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.7 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 0.6 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.0 0.6 PID_BMP_PATHWAY BMP receptor signaling
0.1 0.5 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 0.5 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.1 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 7.3 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.4 6.1 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.2 5.8 REACTOME_KINESINS Genes involved in Kinesins
1.2 4.7 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.3 4.6 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 4.6 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 4.5 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.5 4.2 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 4.2 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 3.5 REACTOME_ER_PHAGOSOME_PATHWAY Genes involved in ER-Phagosome pathway
0.0 2.8 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 2.6 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.1 2.6 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.2 2.1 REACTOME_N_GLYCAN_TRIMMING_IN_THE_ER_AND_CALNEXIN_CALRETICULIN_CYCLE Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.1 1.7 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.1 1.6 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.1 1.5 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 1.3 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 1.3 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events