Motif ID: Creb3l2

Z-value: 0.575


Transcription factors associated with Creb3l2:

Gene SymbolEntrez IDGene Name
Creb3l2 ENSMUSG00000038648.5 Creb3l2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Creb3l2mm10_v2_chr6_-_37442095_37442154-0.239.3e-02Click!


Activity profile for motif Creb3l2.

activity profile for motif Creb3l2


Sorted Z-values histogram for motif Creb3l2

Sorted Z-values for motif Creb3l2



Network of associatons between targets according to the STRING database.



First level regulatory network of Creb3l2

PNG image of the network

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Top targets:


Showing 1 to 20 of 156 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_135251209 3.759 ENSMUST00000062572.2
 Fzd9
frizzled homolog 9 (Drosophila)
chr7_+_19094594 3.305 ENSMUST00000049454.5
 Six5
sine oculis-related homeobox 5
chr7_-_25250720 3.264 ENSMUST00000116343.2
ENSMUST00000045847.8
 Erf

Ets2 repressor factor

chr3_-_20155069 2.618 ENSMUST00000184552.1
ENSMUST00000178328.1
 Gyg

glycogenin

chr15_+_79516396 2.537 ENSMUST00000010974.7
 Kdelr3
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
chr9_-_43239816 2.498 ENSMUST00000034512.5
 Oaf
OAF homolog (Drosophila)
chr5_-_30945393 2.471 ENSMUST00000031051.6
 Cgref1
cell growth regulator with EF hand domain 1
chr2_-_105399286 2.401 ENSMUST00000006128.6
 Rcn1
reticulocalbin 1
chr6_+_56832059 2.237 ENSMUST00000031795.7
 Fkbp9
FK506 binding protein 9
chr11_+_100415697 1.861 ENSMUST00000001595.3
 Fkbp10
FK506 binding protein 10
chr11_-_94653964 1.774 ENSMUST00000039949.4
 Eme1
essential meiotic endonuclease 1 homolog 1 (S. pombe)
chr10_+_13090788 1.750 ENSMUST00000121646.1
ENSMUST00000121325.1
ENSMUST00000121766.1
 Plagl1


pleiomorphic adenoma gene-like 1


chr2_+_84840612 1.731 ENSMUST00000111625.1
 Slc43a1
solute carrier family 43, member 1
chr8_+_14911663 1.711 ENSMUST00000084207.5
ENSMUST00000161162.1
ENSMUST00000110800.2
 Arhgef10


Rho guanine nucleotide exchange factor (GEF) 10


chr11_+_100415722 1.564 ENSMUST00000107400.2
 Fkbp10
FK506 binding protein 10
chr3_+_104638658 1.508 ENSMUST00000046212.1
 Slc16a1
solute carrier family 16 (monocarboxylic acid transporters), member 1
chr19_-_4201591 1.466 ENSMUST00000025740.6
 Rad9a
RAD9 homolog A
chr15_+_34238026 1.411 ENSMUST00000022867.3
 Laptm4b
lysosomal-associated protein transmembrane 4B
chr10_+_20148920 1.405 ENSMUST00000116259.3
 Map7
microtubule-associated protein 7
chrX_+_50841434 1.267 ENSMUST00000114887.2
 2610018G03Rik
RIKEN cDNA 2610018G03 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 3.8 GO:1990523 bone regeneration(GO:1990523)
0.1 3.4 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.7 3.3 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.3 3.3 GO:0014842 regulation of skeletal muscle satellite cell proliferation(GO:0014842)
0.4 3.0 GO:0006621 protein retention in ER lumen(GO:0006621)
0.1 2.7 GO:0015804 neutral amino acid transport(GO:0015804)
0.0 2.2 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.0 2.1 GO:0007050 cell cycle arrest(GO:0007050)
0.1 2.0 GO:0033327 Leydig cell differentiation(GO:0033327)
0.4 1.8 GO:0072429 response to intra-S DNA damage checkpoint signaling(GO:0072429)
0.0 1.7 GO:0032292 myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
0.0 1.7 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.4 1.5 GO:0006526 arginine biosynthetic process(GO:0006526)
0.2 1.5 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.1 1.5 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.1 1.2 GO:0005980 polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.0 1.2 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.4 1.1 GO:0009446 putrescine biosynthetic process(GO:0009446)
0.3 1.1 GO:0006244 pyrimidine nucleotide catabolic process(GO:0006244) pyrimidine deoxyribonucleotide catabolic process(GO:0009223)
0.2 1.1 GO:0072717 cellular response to actinomycin D(GO:0072717)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.8 GO:0031527 filopodium membrane(GO:0031527)
0.4 1.8 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.2 1.5 GO:0030896 checkpoint clamp complex(GO:0030896)
0.0 1.5 GO:0016363 nuclear matrix(GO:0016363)
0.0 1.4 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.4 GO:0015934 large ribosomal subunit(GO:0015934)
0.2 1.2 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.2 1.0 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.1 1.0 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 1.0 GO:0016342 catenin complex(GO:0016342)
0.1 0.8 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.1 0.8 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.8 GO:0005844 polysome(GO:0005844)
0.2 0.7 GO:0030905 retromer, tubulation complex(GO:0030905)
0.0 0.6 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 0.5 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
0.0 0.5 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.5 GO:1990023 mitotic spindle midzone(GO:1990023)
0.1 0.4 GO:0034715 pICln-Sm protein complex(GO:0034715)
0.1 0.4 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5.7 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.2 3.8 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 3.3 GO:0003714 transcription corepressor activity(GO:0003714)
0.7 3.0 GO:0046923 ER retention sequence binding(GO:0046923)
0.3 2.6 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.2 1.8 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.1 1.7 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 1.7 GO:0019894 kinesin binding(GO:0019894)
0.4 1.5 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.4 1.5 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.2 1.5 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.3 1.2 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.3 1.1 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.2 1.1 GO:1990948 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.1 1.1 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.0 1.1 GO:0016831 carboxy-lyase activity(GO:0016831)
0.1 1.0 GO:0005072 transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072) activin binding(GO:0048185)
0.1 1.0 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.3 0.9 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.2 0.9 GO:0004096 catalase activity(GO:0004096)

Gene overrepresentation in C2:CP category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.8 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 2.9 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 2.3 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 1.7 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 1.6 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 1.1 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 1.0 PID_ALK1_PATHWAY ALK1 signaling events
0.0 0.7 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.0 0.6 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.5 ST_JAK_STAT_PATHWAY Jak-STAT Pathway
0.0 0.4 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.4 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.8 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 3.0 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 2.7 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 2.3 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 1.8 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.2 1.5 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 1.5 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.0 1.5 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS Genes involved in Activation of ATR in response to replication stress
0.1 1.3 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 1.3 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 1.2 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 1.1 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.0 1.1 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.1 1.0 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 1.0 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.9 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
0.0 0.7 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.6 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.4 REACTOME_INTEGRATION_OF_PROVIRUS Genes involved in Integration of provirus
0.0 0.4 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases