Motif ID: Crem_Jdp2

Z-value: 0.527

Transcription factors associated with Crem_Jdp2:

Gene SymbolEntrez IDGene Name
Crem ENSMUSG00000063889.10 Crem
Jdp2 ENSMUSG00000034271.9 Jdp2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Jdp2mm10_v2_chr12_+_85599388_85599416-0.455.5e-04Click!
Cremmm10_v2_chr18_-_3281036_3281132-0.293.0e-02Click!


Activity profile for motif Crem_Jdp2.

activity profile for motif Crem_Jdp2


Sorted Z-values histogram for motif Crem_Jdp2

Sorted Z-values for motif Crem_Jdp2



Network of associatons between targets according to the STRING database.



First level regulatory network of Crem_Jdp2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 7.446 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr11_+_101468164 5.389 ENSMUST00000001347.6
 Rnd2
Rho family GTPase 2
chr17_+_43952999 4.393 ENSMUST00000177857.1
 Rcan2
regulator of calcineurin 2
chr3_+_135212557 4.185 ENSMUST00000062893.7
 Cenpe
centromere protein E
chr17_+_43953191 4.017 ENSMUST00000044792.4
 Rcan2
regulator of calcineurin 2
chr1_+_74791516 3.716 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr1_-_134079114 3.484 ENSMUST00000020692.6
 Btg2
B cell translocation gene 2, anti-proliferative
chr5_-_106458440 3.352 ENSMUST00000086795.6
 Barhl2
BarH-like 2 (Drosophila)
chr7_+_79500018 3.050 ENSMUST00000182495.1
ENSMUST00000183043.1
 AI854517

expressed sequence AI854517

chr2_+_105668888 3.014 ENSMUST00000111086.4
ENSMUST00000111087.3
 Pax6

paired box gene 6

chr15_+_34238026 2.939 ENSMUST00000022867.3
 Laptm4b
lysosomal-associated protein transmembrane 4B
chr11_-_84525514 2.916 ENSMUST00000018842.7
 Lhx1
LIM homeobox protein 1
chr7_+_79500081 2.878 ENSMUST00000181511.2
ENSMUST00000182937.1
 AI854517

expressed sequence AI854517

chr2_+_105668935 2.753 ENSMUST00000142772.1
 Pax6
paired box gene 6
chr2_+_109280738 2.558 ENSMUST00000028527.7
 Kif18a
kinesin family member 18A
chr6_+_113531675 2.381 ENSMUST00000036340.5
ENSMUST00000101051.2
 Fancd2

Fanconi anemia, complementation group D2

chr1_+_135729147 2.362 ENSMUST00000027677.7
 Csrp1
cysteine and glycine-rich protein 1
chr14_+_47472628 2.346 ENSMUST00000095941.2
 Fbxo34
F-box protein 34
chr11_+_84525669 2.329 ENSMUST00000126072.1
ENSMUST00000128121.1
 1500016L03Rik

RIKEN cDNA 1500016L03 gene

chr14_+_47472547 2.279 ENSMUST00000168833.1
ENSMUST00000163324.1
ENSMUST00000043112.7
 Fbxo34


F-box protein 34



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 145 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 8.2 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
1.2 7.4 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.2 5.8 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
0.4 5.4 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
1.1 4.3 GO:1902724 positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728)
0.7 4.2 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.4 3.7 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.1 3.4 GO:0001709 cell fate determination(GO:0001709)
0.2 3.1 GO:0060213 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
1.0 2.9 GO:0072284 cervix development(GO:0060067) metanephric S-shaped body morphogenesis(GO:0072284) anterior head development(GO:0097065) regulation of anterior head development(GO:2000742) positive regulation of anterior head development(GO:2000744)
0.3 2.7 GO:1901386 negative regulation of voltage-gated calcium channel activity(GO:1901386)
0.1 2.6 GO:0072520 seminiferous tubule development(GO:0072520)
0.2 2.5 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.1 2.5 GO:0016572 histone phosphorylation(GO:0016572)
0.0 2.5 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.3 2.4 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.0 2.4 GO:0070527 platelet aggregation(GO:0070527)
0.2 2.3 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.5 2.2 GO:0042414 epinephrine metabolic process(GO:0042414)
0.2 2.2 GO:0014883 transition between fast and slow fiber(GO:0014883)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.0 GO:0000790 nuclear chromatin(GO:0000790)
0.4 5.8 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 4.5 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 3.5 GO:0005769 early endosome(GO:0005769)
0.6 2.5 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.0 2.4 GO:0005844 polysome(GO:0005844)
0.7 2.2 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.2 2.1 GO:0000813 ESCRT I complex(GO:0000813)
0.0 2.1 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 2.1 GO:0016605 PML body(GO:0016605)
0.7 2.0 GO:0043224 nuclear SCF ubiquitin ligase complex(GO:0043224)
0.2 2.0 GO:0030478 actin cap(GO:0030478)
0.1 2.0 GO:0030008 TRAPP complex(GO:0030008)
0.3 1.9 GO:0001940 male pronucleus(GO:0001940)
0.1 1.8 GO:0051233 spindle midzone(GO:0051233)
0.1 1.7 GO:0031045 dense core granule(GO:0031045)
0.0 1.7 GO:0097546 ciliary base(GO:0097546)
0.0 1.6 GO:0005871 kinesin complex(GO:0005871)
0.0 1.5 GO:0016592 mediator complex(GO:0016592)
0.0 1.5 GO:0005720 nuclear heterochromatin(GO:0005720)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 91 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 17.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.4 8.2 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.4 5.8 GO:0003680 AT DNA binding(GO:0003680)
0.0 4.4 GO:0047485 protein N-terminus binding(GO:0047485)
0.8 4.2 GO:0043515 kinetochore binding(GO:0043515)
0.4 4.0 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.1 4.0 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.5 3.4 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.1 3.4 GO:0005109 frizzled binding(GO:0005109)
0.0 2.8 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.1 2.6 GO:0008266 poly(U) RNA binding(GO:0008266)
0.1 2.6 GO:0070182 DNA polymerase binding(GO:0070182)
0.1 2.5 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 2.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 2.4 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.4 2.2 GO:0035240 dopamine binding(GO:0035240)
0.0 2.1 GO:0051015 actin filament binding(GO:0051015)
0.3 2.0 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.6 1.9 GO:0004994 somatostatin receptor activity(GO:0004994)
0.1 1.9 GO:1990841 promoter-specific chromatin binding(GO:1990841)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.6 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 5.5 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 5.4 PID_PLK1_PATHWAY PLK1 signaling events
0.3 5.0 ST_STAT3_PATHWAY STAT3 Pathway
0.2 3.1 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 3.0 PID_CDC42_PATHWAY CDC42 signaling events
0.1 2.4 PID_ATR_PATHWAY ATR signaling pathway
0.1 2.4 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 2.3 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.0 2.0 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.7 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 1.6 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 1.4 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.1 1.1 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.0 1.0 PID_MET_PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 0.9 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.8 PID_FOXO_PATHWAY FoxO family signaling
0.0 0.8 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 0.6 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 0.6 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 5.8 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.4 4.3 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.1 3.7 REACTOME_KINESINS Genes involved in Kinesins
0.0 3.7 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 3.5 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 3.5 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 2.5 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 2.5 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.2 2.4 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.2 2.2 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.3 2.1 REACTOME_MEMBRANE_BINDING_AND_TARGETTING_OF_GAG_PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.1 2.0 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 1.9 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 1.3 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 1.2 REACTOME_AMYLOIDS Genes involved in Amyloids
0.0 1.2 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.2 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 1.0 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 1.0 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 0.9 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes