Motif ID: Crx_Gsc

Z-value: 0.414

Transcription factors associated with Crx_Gsc:

Gene SymbolEntrez IDGene Name
Crx ENSMUSG00000041578.9 Crx
Gsc ENSMUSG00000021095.4 Gsc

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Crxmm10_v2_chr7_-_15879844_158799680.284.2e-02Click!


Activity profile for motif Crx_Gsc.

activity profile for motif Crx_Gsc


Sorted Z-values histogram for motif Crx_Gsc

Sorted Z-values for motif Crx_Gsc



Network of associatons between targets according to the STRING database.



First level regulatory network of Crx_Gsc

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_74013442 2.409 ENSMUST00000098006.2
ENSMUST00000084474.5
 Frmd3

FERM domain containing 3

chrY_+_1010543 2.261 ENSMUST00000091197.3
 Eif2s3y
eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked
chr11_+_104231390 2.129 ENSMUST00000106992.3
 Mapt
microtubule-associated protein tau
chr14_+_65968483 2.054 ENSMUST00000022616.6
 Clu
clusterin
chr13_+_110395041 1.910 ENSMUST00000022212.7
 Plk2
polo-like kinase 2
chr6_-_59426279 1.458 ENSMUST00000051065.4
 Gprin3
GPRIN family member 3
chr14_-_19977249 1.413 ENSMUST00000160013.1
 Gng2
guanine nucleotide binding protein (G protein), gamma 2
chr1_-_154725920 1.310 ENSMUST00000004214.8
 Cacna1e
calcium channel, voltage-dependent, R type, alpha 1E subunit
chr9_-_53975246 1.289 ENSMUST00000048409.7
 Elmod1
ELMO/CED-12 domain containing 1
chr10_+_90576872 1.251 ENSMUST00000182550.1
ENSMUST00000099364.5
 Anks1b

ankyrin repeat and sterile alpha motif domain containing 1B

chr14_-_19977151 1.224 ENSMUST00000055100.7
ENSMUST00000162425.1
 Gng2

guanine nucleotide binding protein (G protein), gamma 2

chr14_-_19977040 1.185 ENSMUST00000159028.1
 Gng2
guanine nucleotide binding protein (G protein), gamma 2
chr7_-_140082246 1.066 ENSMUST00000166758.2
 Caly
calcyon neuron-specific vesicular protein
chr9_+_109051090 1.039 ENSMUST00000059097.8
 Shisa5
shisa homolog 5 (Xenopus laevis)
chr4_-_138396438 1.037 ENSMUST00000105032.2
 Fam43b
family with sequence similarity 43, member B
chr8_-_54724317 1.031 ENSMUST00000129132.2
ENSMUST00000150488.1
ENSMUST00000127511.2
 Wdr17


WD repeat domain 17


chr11_-_70459957 0.997 ENSMUST00000019064.2
 Cxcl16
chemokine (C-X-C motif) ligand 16
chr17_+_55445550 0.946 ENSMUST00000025000.3
 St6gal2
beta galactoside alpha 2,6 sialyltransferase 2
chr12_+_81631369 0.941 ENSMUST00000036116.5
 Ttc9
tetratricopeptide repeat domain 9
chr1_-_152625212 0.921 ENSMUST00000027760.7
 Rgl1
ral guanine nucleotide dissociation stimulator,-like 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 88 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.3 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.3 2.1 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.2 2.1 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.1 1.9 GO:0032486 Rap protein signal transduction(GO:0032486)
0.0 1.7 GO:0006413 translational initiation(GO:0006413)
0.3 1.6 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.0 1.6 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.3 1.3 GO:0090273 regulation of somatostatin secretion(GO:0090273)
0.1 1.3 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.0 1.3 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0 1.1 GO:0048268 clathrin coat assembly(GO:0048268)
0.1 1.0 GO:0010818 T cell chemotaxis(GO:0010818)
0.1 0.9 GO:0019532 oxalate transport(GO:0019532)
0.1 0.9 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.2 0.8 GO:2000705 regulation of dense core granule biogenesis(GO:2000705)
0.1 0.8 GO:0033574 response to testosterone(GO:0033574)
0.0 0.8 GO:0043045 DNA methylation involved in embryo development(GO:0043045) changes to DNA methylation involved in embryo development(GO:1901538)
0.0 0.8 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 0.7 GO:0045578 negative regulation of B cell differentiation(GO:0045578) epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.1 0.7 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.2 GO:0097418 neurofibrillary tangle(GO:0097418)
0.1 2.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 2.1 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 2.1 GO:0005814 centriole(GO:0005814)
0.3 1.6 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.0 0.9 GO:0071564 npBAF complex(GO:0071564)
0.0 0.8 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 0.7 GO:0031143 pseudopodium(GO:0031143)
0.0 0.7 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.7 GO:0043034 costamere(GO:0043034)
0.0 0.7 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.6 GO:0002102 podosome(GO:0002102)
0.1 0.4 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.4 GO:0042581 specific granule(GO:0042581)
0.0 0.4 GO:0060170 ciliary membrane(GO:0060170)
0.1 0.3 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 0.3 GO:0032585 multivesicular body membrane(GO:0032585)
0.0 0.3 GO:0002177 manchette(GO:0002177)
0.0 0.3 GO:0097165 nuclear stress granule(GO:0097165)
0.0 0.3 GO:0005892 acetylcholine-gated channel complex(GO:0005892)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.5 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.1 2.8 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 2.5 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.3 2.1 GO:0099609 microtubule lateral binding(GO:0099609)
0.2 2.1 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 2.1 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 2.0 GO:0051787 misfolded protein binding(GO:0051787)
0.1 1.9 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.3 1.6 GO:0097643 amylin receptor activity(GO:0097643)
0.0 1.3 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 1.1 GO:0032051 clathrin light chain binding(GO:0032051)
0.0 1.0 GO:0050699 WW domain binding(GO:0050699)
0.2 0.9 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 0.9 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.1 0.9 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.1 0.8 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.8 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.2 0.7 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.1 0.7 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.1 0.7 GO:0015279 store-operated calcium channel activity(GO:0015279) inositol 1,4,5 trisphosphate binding(GO:0070679)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 3.8 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 2.8 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 2.1 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 1.0 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.9 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 0.7 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.6 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.5 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 0.5 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.4 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.8 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 2.2 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 2.1 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.9 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.0 0.8 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.7 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.7 REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0 0.6 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.3 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.3 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 0.3 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.3 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.2 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.1 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint