Motif ID: Ctcfl_Ctcf

Z-value: 0.963

Transcription factors associated with Ctcfl_Ctcf:

Gene SymbolEntrez IDGene Name
Ctcf ENSMUSG00000005698.9 Ctcf
Ctcfl ENSMUSG00000070495.5 Ctcfl

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ctcflmm10_v2_chr2_-_173119402_173119525-0.143.2e-01Click!
Ctcfmm10_v2_chr8_+_105636509_1056365890.057.3e-01Click!


Activity profile for motif Ctcfl_Ctcf.

activity profile for motif Ctcfl_Ctcf


Sorted Z-values histogram for motif Ctcfl_Ctcf

Sorted Z-values for motif Ctcfl_Ctcf



Network of associatons between targets according to the STRING database.



First level regulatory network of Ctcfl_Ctcf

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_34486125 11.255 ENSMUST00000115148.2
ENSMUST00000183580.1
 Kirrel3
RP24-225I21.1
kin of IRRE like 3 (Drosophila)
RP24-225I21.1
chr13_-_54055650 9.650 ENSMUST00000021932.5
 Drd1a
dopamine receptor D1A
chr11_+_103103051 8.621 ENSMUST00000152971.1
 Acbd4
acyl-Coenzyme A binding domain containing 4
chr2_+_65620829 8.509 ENSMUST00000028377.7
 Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr6_-_136173492 8.286 ENSMUST00000111905.1
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr18_+_36952621 8.260 ENSMUST00000115661.2
 Pcdha2
protocadherin alpha 2
chr5_-_123132651 8.044 ENSMUST00000031401.5
 Rhof
ras homolog gene family, member f
chr2_-_32353283 7.794 ENSMUST00000091089.5
ENSMUST00000113350.1
 Dnm1

dynamin 1

chr18_-_66291770 7.770 ENSMUST00000130300.1
 Ccbe1
collagen and calcium binding EGF domains 1
chr2_-_32353247 7.664 ENSMUST00000078352.5
ENSMUST00000113352.2
ENSMUST00000113365.1
 Dnm1


dynamin 1


chr11_-_109298066 7.151 ENSMUST00000106706.1
 Rgs9
regulator of G-protein signaling 9
chr19_+_6418731 7.144 ENSMUST00000113462.1
ENSMUST00000077182.6
ENSMUST00000113461.1
 Nrxn2


neurexin II


chr11_+_32286946 6.953 ENSMUST00000101387.3
 Hbq1b
hemoglobin, theta 1B
chr18_-_43393346 6.892 ENSMUST00000025379.7
 Dpysl3
dihydropyrimidinase-like 3
chr15_-_44788016 6.841 ENSMUST00000090057.4
ENSMUST00000110269.1
 Sybu

syntabulin (syntaxin-interacting)

chr16_-_26371828 6.741 ENSMUST00000023154.2
 Cldn1
claudin 1
chr9_-_102354685 6.678 ENSMUST00000035129.7
ENSMUST00000085169.5
 Ephb1

Eph receptor B1

chr11_-_45944910 6.277 ENSMUST00000129820.1
 Lsm11
U7 snRNP-specific Sm-like protein LSM11
chr11_-_109298121 6.126 ENSMUST00000020920.3
 Rgs9
regulator of G-protein signaling 9
chr11_+_84179792 6.053 ENSMUST00000137500.2
ENSMUST00000130012.2
 Acaca

acetyl-Coenzyme A carboxylase alpha


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 208 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 28.5 GO:0007416 synapse assembly(GO:0007416)
2.3 20.3 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.4 16.3 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
2.2 15.5 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
2.3 11.3 GO:0002121 inter-male aggressive behavior(GO:0002121)
2.7 10.9 GO:0044268 multicellular organismal protein metabolic process(GO:0044268)
2.3 9.2 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
2.1 8.3 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
2.7 8.2 GO:0016256 N-glycan processing to lysosome(GO:0016256)
1.9 7.8 GO:1901492 positive regulation of lymphangiogenesis(GO:1901492)
0.1 7.8 GO:0035725 sodium ion transmembrane transport(GO:0035725)
2.5 7.6 GO:0043181 vacuolar sequestering(GO:0043181)
0.4 7.1 GO:0042297 vocal learning(GO:0042297) imitative learning(GO:0098596)
0.3 6.9 GO:0051764 actin crosslink formation(GO:0051764)
2.2 6.7 GO:1903348 positive regulation of bicellular tight junction assembly(GO:1903348)
1.3 6.7 GO:2001015 negative regulation of skeletal muscle cell differentiation(GO:2001015)
0.8 6.7 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.8 6.3 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.1 6.3 GO:1903749 positive regulation of establishment of protein localization to mitochondrion(GO:1903749)
0.2 6.1 GO:0061098 positive regulation of protein tyrosine kinase activity(GO:0061098)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 106 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 30.8 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 25.4 GO:0070382 exocytic vesicle(GO:0070382)
1.3 21.3 GO:0043196 varicosity(GO:0043196)
2.0 20.3 GO:0045298 tubulin complex(GO:0045298)
0.1 18.7 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.4 15.3 GO:0001917 photoreceptor inner segment(GO:0001917)
0.2 14.5 GO:0043198 dendritic shaft(GO:0043198)
0.1 11.1 GO:0000139 Golgi membrane(GO:0000139)
0.7 10.2 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 9.8 GO:0001650 fibrillar center(GO:0001650)
0.0 9.3 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.1 9.1 GO:0045211 postsynaptic membrane(GO:0045211)
0.2 8.6 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.6 8.3 GO:0043083 synaptic cleft(GO:0043083)
0.1 7.0 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.9 6.8 GO:0097433 dense body(GO:0097433)
0.1 6.4 GO:0042734 presynaptic membrane(GO:0042734)
1.3 6.3 GO:0005683 U7 snRNP(GO:0005683)
0.1 6.3 GO:0031901 early endosome membrane(GO:0031901)
0.0 5.9 GO:0005743 mitochondrial inner membrane(GO:0005743)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 140 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.4 23.7 GO:0031749 D2 dopamine receptor binding(GO:0031749)
2.9 20.3 GO:0099609 microtubule lateral binding(GO:0099609)
0.0 13.0 GO:0030695 GTPase regulator activity(GO:0030695)
0.2 11.2 GO:0001540 beta-amyloid binding(GO:0001540)
3.6 10.9 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.1 10.4 GO:0030165 PDZ domain binding(GO:0030165)
2.6 10.2 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.6 10.2 GO:0005248 voltage-gated sodium channel activity(GO:0005248)
2.1 8.2 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.1 8.0 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 7.8 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.9 7.7 GO:0008046 axon guidance receptor activity(GO:0008046)
2.5 7.6 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
0.1 7.4 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.8 6.9 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.2 6.8 GO:0017075 syntaxin-1 binding(GO:0017075)
0.7 6.7 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.5 6.7 GO:0001618 virus receptor activity(GO:0001618)
0.2 6.7 GO:0005246 calcium channel regulator activity(GO:0005246)
0.1 6.6 GO:0051117 ATPase binding(GO:0051117)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 22.1 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
1.1 20.3 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
1.4 15.3 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.1 12.5 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.3 10.4 PID_REELIN_PATHWAY Reelin signaling pathway
0.3 9.6 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.2 9.5 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.1 8.6 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 7.9 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 6.4 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 6.3 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.4 5.7 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.2 5.1 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 3.9 PID_SHP2_PATHWAY SHP2 signaling
0.0 3.6 NABA_MATRISOME_ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.2 3.5 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.2 2.7 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 2.5 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 2.4 PID_CMYB_PATHWAY C-MYB transcription factor network
0.1 2.2 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 20.3 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.9 16.2 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.1 15.3 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.2 11.2 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.3 10.9 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.5 10.8 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 9.9 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.4 9.2 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.3 8.3 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.3 8.0 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.2 6.7 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.2 6.7 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.1 5.9 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.2 5.7 REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.2 4.8 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.1 4.8 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 4.5 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 4.5 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 4.4 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.3 4.2 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors