Motif ID: Cxxc1

Z-value: 0.516


Transcription factors associated with Cxxc1:

Gene SymbolEntrez IDGene Name
Cxxc1 ENSMUSG00000024560.6 Cxxc1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Cxxc1mm10_v2_chr18_+_74216118_74216145-0.375.2e-03Click!


Activity profile for motif Cxxc1.

activity profile for motif Cxxc1


Sorted Z-values histogram for motif Cxxc1

Sorted Z-values for motif Cxxc1



Network of associatons between targets according to the STRING database.



First level regulatory network of Cxxc1

PNG image of the network

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Top targets:


Showing 1 to 20 of 58 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_89302545 4.626 ENSMUST00000061728.3
 Nog
noggin
chr11_-_69921057 2.034 ENSMUST00000108609.1
ENSMUST00000108608.1
ENSMUST00000164359.1
 Eif5a


eukaryotic translation initiation factor 5A


chr11_+_97415527 1.789 ENSMUST00000121799.1
 Arhgap23
Rho GTPase activating protein 23
chr11_-_69920892 1.565 ENSMUST00000152589.1
ENSMUST00000108612.1
ENSMUST00000108611.1
 Eif5a


eukaryotic translation initiation factor 5A


chr3_-_8964037 1.468 ENSMUST00000091354.5
ENSMUST00000094381.4
 Tpd52

tumor protein D52

chr17_-_14203695 1.350 ENSMUST00000053218.5
 Dact2
dapper homolog 2, antagonist of beta-catenin (xenopus)
chr7_-_49636847 1.339 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr1_-_124045523 1.155 ENSMUST00000112606.1
 Dpp10
dipeptidylpeptidase 10
chr19_-_36919606 1.077 ENSMUST00000057337.7
 Fgfbp3
fibroblast growth factor binding protein 3
chr5_-_125389177 1.073 ENSMUST00000108707.2
 Ubc
ubiquitin C
chr8_+_70594466 1.060 ENSMUST00000019283.9
 Isyna1
myo-inositol 1-phosphate synthase A1
chr5_+_30588078 1.050 ENSMUST00000066295.2
 Kcnk3
potassium channel, subfamily K, member 3
chr11_-_69920581 1.006 ENSMUST00000108610.1
 Eif5a
eukaryotic translation initiation factor 5A
chr1_-_124045247 0.963 ENSMUST00000112603.2
 Dpp10
dipeptidylpeptidase 10
chr3_+_68869563 0.933 ENSMUST00000054551.2
 1110032F04Rik
RIKEN cDNA 1110032F04 gene
chr2_+_112239468 0.845 ENSMUST00000028554.3
 Lpcat4
lysophosphatidylcholine acyltransferase 4
chr19_-_4439388 0.770 ENSMUST00000117462.1
ENSMUST00000048197.3
 Rhod

ras homolog gene family, member D

chr11_-_68386974 0.761 ENSMUST00000135141.1
 Ntn1
netrin 1
chr18_-_43477764 0.687 ENSMUST00000057110.9
 Eif3j2
eukaryotic translation initiation factor 3, subunit J2
chr12_+_110279228 0.683 ENSMUST00000097228.4
 Dio3
deiodinase, iodothyronine type III

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 4.6 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
0.8 4.6 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.0 2.1 GO:1903078 positive regulation of protein localization to plasma membrane(GO:1903078)
0.4 1.3 GO:1900108 negative regulation of nodal signaling pathway(GO:1900108)
0.1 1.3 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.1 1.3 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.2 1.2 GO:0046549 retinal cone cell development(GO:0046549)
0.1 1.1 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.1 1.1 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 1.1 GO:0006020 inositol metabolic process(GO:0006020)
0.0 1.1 GO:0002181 cytoplasmic translation(GO:0002181)
0.1 0.8 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.0 0.8 GO:2000249 regulation of actin cytoskeleton reorganization(GO:2000249)
0.2 0.7 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.1 0.6 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.5 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 0.5 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.1 0.4 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.1 0.4 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 0.1 GO:1902340 telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340)

Gene overrepresentation in cellular_component category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 4.6 GO:0005642 annulate lamellae(GO:0005642)
0.0 2.1 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 1.3 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 1.1 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.7 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.7 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.6 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.5 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 0.3 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.1 0.2 GO:1990047 spindle matrix(GO:1990047)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.6 GO:0017070 U6 snRNA binding(GO:0017070)
0.1 4.6 GO:0019955 cytokine binding(GO:0019955)
0.4 2.1 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 1.6 GO:0002020 protease binding(GO:0002020)
0.3 1.3 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.1 1.3 GO:0070097 delta-catenin binding(GO:0070097)
0.1 1.1 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 1.1 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 1.1 GO:0019843 rRNA binding(GO:0019843)
0.3 0.8 GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.0 0.7 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.7 GO:0003743 translation initiation factor activity(GO:0003743)
0.2 0.6 GO:0008502 melatonin receptor activity(GO:0008502)
0.0 0.5 GO:0048038 quinone binding(GO:0048038)
0.0 0.5 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 0.4 GO:0046923 ER retention sequence binding(GO:0046923)
0.0 0.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 0.3 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.1 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0 0.1 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.6 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.3 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 1.3 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 0.8 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 0.4 PID_WNT_SIGNALING_PATHWAY Wnt signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.6 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.2 4.6 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 1.5 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.2 1.1 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 1.1 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.1 0.8 REACTOME_ACYL_CHAIN_REMODELLING_OF_PS Genes involved in Acyl chain remodelling of PS
0.1 0.8 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.1 0.7 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 0.7 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis