Motif ID: Cxxc1

Z-value: 0.516


Transcription factors associated with Cxxc1:

Gene SymbolEntrez IDGene Name
Cxxc1 ENSMUSG00000024560.6 Cxxc1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Cxxc1mm10_v2_chr18_+_74216118_74216145-0.375.2e-03Click!


Activity profile for motif Cxxc1.

activity profile for motif Cxxc1


Sorted Z-values histogram for motif Cxxc1

Sorted Z-values for motif Cxxc1



Network of associatons between targets according to the STRING database.



First level regulatory network of Cxxc1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_89302545 4.626 ENSMUST00000061728.3
 Nog
noggin
chr11_-_69921057 2.034 ENSMUST00000108609.1
ENSMUST00000108608.1
ENSMUST00000164359.1
 Eif5a


eukaryotic translation initiation factor 5A


chr11_+_97415527 1.789 ENSMUST00000121799.1
 Arhgap23
Rho GTPase activating protein 23
chr11_-_69920892 1.565 ENSMUST00000152589.1
ENSMUST00000108612.1
ENSMUST00000108611.1
 Eif5a


eukaryotic translation initiation factor 5A


chr3_-_8964037 1.468 ENSMUST00000091354.5
ENSMUST00000094381.4
 Tpd52

tumor protein D52

chr17_-_14203695 1.350 ENSMUST00000053218.5
 Dact2
dapper homolog 2, antagonist of beta-catenin (xenopus)
chr7_-_49636847 1.339 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr1_-_124045523 1.155 ENSMUST00000112606.1
 Dpp10
dipeptidylpeptidase 10
chr19_-_36919606 1.077 ENSMUST00000057337.7
 Fgfbp3
fibroblast growth factor binding protein 3
chr5_-_125389177 1.073 ENSMUST00000108707.2
 Ubc
ubiquitin C
chr8_+_70594466 1.060 ENSMUST00000019283.9
 Isyna1
myo-inositol 1-phosphate synthase A1
chr5_+_30588078 1.050 ENSMUST00000066295.2
 Kcnk3
potassium channel, subfamily K, member 3
chr11_-_69920581 1.006 ENSMUST00000108610.1
 Eif5a
eukaryotic translation initiation factor 5A
chr1_-_124045247 0.963 ENSMUST00000112603.2
 Dpp10
dipeptidylpeptidase 10
chr3_+_68869563 0.933 ENSMUST00000054551.2
 1110032F04Rik
RIKEN cDNA 1110032F04 gene
chr2_+_112239468 0.845 ENSMUST00000028554.3
 Lpcat4
lysophosphatidylcholine acyltransferase 4
chr19_-_4439388 0.770 ENSMUST00000117462.1
ENSMUST00000048197.3
 Rhod

ras homolog gene family, member D

chr11_-_68386974 0.761 ENSMUST00000135141.1
 Ntn1
netrin 1
chr18_-_43477764 0.687 ENSMUST00000057110.9
 Eif3j2
eukaryotic translation initiation factor 3, subunit J2
chr12_+_110279228 0.683 ENSMUST00000097228.4
 Dio3
deiodinase, iodothyronine type III
chr10_+_128058974 0.680 ENSMUST00000084771.2
 Ptges3
prostaglandin E synthase 3 (cytosolic)
chr8_-_122443404 0.669 ENSMUST00000006692.4
 Mvd
mevalonate (diphospho) decarboxylase
chr15_+_74516196 0.662 ENSMUST00000042035.9
 Bai1
brain-specific angiogenesis inhibitor 1
chr10_+_128058947 0.660 ENSMUST00000052798.7
 Ptges3
prostaglandin E synthase 3 (cytosolic)
chr5_+_125389284 0.603 ENSMUST00000100700.2
 Gm10382
predicted gene 10382
chr8_+_92357787 0.587 ENSMUST00000034184.10
 Irx5
Iroquois related homeobox 5 (Drosophila)
chr10_+_50895651 0.580 ENSMUST00000020071.3
 Sim1
single-minded homolog 1 (Drosophila)
chr19_-_19111181 0.565 ENSMUST00000112832.1
 Rorb
RAR-related orphan receptor beta
chr5_-_65391408 0.565 ENSMUST00000057885.6
 Rpl9
ribosomal protein L9
chr5_-_65391380 0.560 ENSMUST00000120094.1
ENSMUST00000118543.1
ENSMUST00000127874.1
 Rpl9


ribosomal protein L9


chr5_-_125389915 0.555 ENSMUST00000136312.1
 Ubc
ubiquitin C
chr10_-_79766872 0.522 ENSMUST00000047203.8
 Rnf126
ring finger protein 126
chr3_-_101307079 0.522 ENSMUST00000097146.2
 Gm10355
predicted gene 10355
chr10_+_80249441 0.520 ENSMUST00000020361.6
 Ndufs7
NADH dehydrogenase (ubiquinone) Fe-S protein 7
chr5_-_4758216 0.405 ENSMUST00000054294.4
 Fzd1
frizzled homolog 1 (Drosophila)
chr5_+_143403819 0.352 ENSMUST00000110731.2
 Kdelr2
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
chr12_-_54656496 0.347 ENSMUST00000056228.6
 Sptssa
serine palmitoyltransferase, small subunit A
chr11_+_32205411 0.335 ENSMUST00000039601.3
ENSMUST00000149043.1
 Snrnp25

small nuclear ribonucleoprotein 25 (U11/U12)

chr11_+_32205483 0.311 ENSMUST00000121182.1
 Snrnp25
small nuclear ribonucleoprotein 25 (U11/U12)
chr10_+_85928491 0.291 ENSMUST00000170396.1
 Ascl4
achaete-scute complex homolog 4 (Drosophila)
chr11_+_80383279 0.199 ENSMUST00000165565.1
ENSMUST00000017567.7
 Zfp207

zinc finger protein 207

chr7_+_45896941 0.146 ENSMUST00000069772.7
ENSMUST00000107716.1
 Tmem143

transmembrane protein 143

chrX_-_158043266 0.139 ENSMUST00000026750.8
ENSMUST00000112513.1
 Cnksr2

connector enhancer of kinase suppressor of Ras 2

chr8_-_111393810 0.113 ENSMUST00000038475.8
 Fa2h
fatty acid 2-hydroxylase
chr9_-_78109020 0.110 ENSMUST00000001402.7
 Fbxo9
f-box protein 9
chr10_-_7681118 0.106 ENSMUST00000159977.1
ENSMUST00000162682.1
 Pcmt1

protein-L-isoaspartate (D-aspartate) O-methyltransferase 1

chrX_+_53607918 0.099 ENSMUST00000114827.1
 Cxx1c
CAAX box 1C
chrX_+_48623737 0.097 ENSMUST00000114936.1
 Slc25a14
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr9_-_78108617 0.092 ENSMUST00000085311.6
 Fbxo9
f-box protein 9
chrX_-_106011874 0.082 ENSMUST00000033583.7
ENSMUST00000151689.1
 Magt1

magnesium transporter 1

chr1_-_180813534 0.069 ENSMUST00000159789.1
ENSMUST00000081026.4
 H3f3a

H3 histone, family 3A

chrX_-_7375830 0.058 ENSMUST00000115744.1
 Usp27x
ubiquitin specific peptidase 27, X chromosome
chr11_+_88068242 0.058 ENSMUST00000018521.4
 Vezf1
vascular endothelial zinc finger 1
chr5_+_65391497 0.045 ENSMUST00000031101.3
ENSMUST00000122026.1
 Lias

lipoic acid synthetase

chr19_+_38931008 0.043 ENSMUST00000145051.1
 Hells
helicase, lymphoid specific
chr11_-_77489666 0.018 ENSMUST00000037593.7
ENSMUST00000092892.3
 Ankrd13b

ankyrin repeat domain 13b

chr10_+_126978690 0.013 ENSMUST00000105256.2
 Ctdsp2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
chr7_+_128744870 0.005 ENSMUST00000042942.8
 Sec23ip
Sec23 interacting protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.6 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
0.8 4.6 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.4 1.3 GO:1900108 negative regulation of nodal signaling pathway(GO:1900108)
0.2 1.2 GO:0046549 retinal cone cell development(GO:0046549)
0.2 0.7 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.1 0.4 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.1 1.1 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.1 1.3 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.1 1.1 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 0.6 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.1 1.1 GO:0006020 inositol metabolic process(GO:0006020)
0.1 0.8 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.1 1.3 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.1 0.4 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 0.5 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 2.1 GO:1903078 positive regulation of protein localization to plasma membrane(GO:1903078)
0.0 0.8 GO:2000249 regulation of actin cytoskeleton reorganization(GO:2000249)
0.0 0.1 GO:1902340 telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340)
0.0 1.1 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 0.0 GO:0009106 lipoate metabolic process(GO:0009106)
0.0 0.0 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
0.0 0.1 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.0 0.5 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 4.6 GO:0005642 annulate lamellae(GO:0005642)
0.1 0.2 GO:1990047 spindle matrix(GO:1990047)
0.1 0.3 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 1.3 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 0.7 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.7 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.6 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 2.1 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 1.1 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.5 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.1 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.3 1.3 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.3 4.6 GO:0017070 U6 snRNA binding(GO:0017070)
0.3 0.8 GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.2 0.6 GO:0008502 melatonin receptor activity(GO:0008502)
0.1 0.3 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.1 1.3 GO:0070097 delta-catenin binding(GO:0070097)
0.1 1.1 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 0.4 GO:0046923 ER retention sequence binding(GO:0046923)
0.1 4.6 GO:0019955 cytokine binding(GO:0019955)
0.0 0.5 GO:0048038 quinone binding(GO:0048038)
0.0 1.1 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 0.1 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0 0.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.5 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.0 GO:0016979 lipoate-protein ligase activity(GO:0016979)
0.0 1.1 GO:0019843 rRNA binding(GO:0019843)
0.0 0.7 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 1.6 GO:0002020 protease binding(GO:0002020)
0.0 0.1 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.7 GO:0003743 translation initiation factor activity(GO:0003743)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.6 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.8 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 1.3 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 1.3 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 0.4 PID_WNT_SIGNALING_PATHWAY Wnt signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.6 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.2 4.6 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.2 1.1 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 0.8 REACTOME_ACYL_CHAIN_REMODELLING_OF_PS Genes involved in Acyl chain remodelling of PS
0.1 0.8 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.1 0.7 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 0.7 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.5 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 1.1 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation