Motif ID: Ddit3

Z-value: 0.707


Transcription factors associated with Ddit3:

Gene SymbolEntrez IDGene Name
Ddit3 ENSMUSG00000025408.9 Ddit3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ddit3mm10_v2_chr10_+_127290774_1272908030.009.8e-01Click!


Activity profile for motif Ddit3.

activity profile for motif Ddit3


Sorted Z-values histogram for motif Ddit3

Sorted Z-values for motif Ddit3



Network of associatons between targets according to the STRING database.



First level regulatory network of Ddit3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_-_109823585 7.505 ENSMUST00000161582.1
Nav3
neuron navigator 3
chr19_-_59076069 6.389 ENSMUST00000047511.7
ENSMUST00000163821.1
4930506M07Rik

RIKEN cDNA 4930506M07 gene

chr15_-_66948419 6.202 ENSMUST00000167817.1
Ndrg1
N-myc downstream regulated gene 1
chrX_+_103422010 6.186 ENSMUST00000182089.1
Gm26992
predicted gene, 26992
chr9_-_121495678 5.904 ENSMUST00000035120.4
Cck
cholecystokinin
chr5_+_137288273 5.217 ENSMUST00000024099.4
ENSMUST00000085934.3
Ache

acetylcholinesterase

chr6_+_21215472 4.740 ENSMUST00000081542.5
Kcnd2
potassium voltage-gated channel, Shal-related family, member 2
chr5_+_137553517 4.031 ENSMUST00000136088.1
ENSMUST00000139395.1
ENSMUST00000136565.1
ENSMUST00000149292.1
ENSMUST00000125489.1
Actl6b




actin-like 6B




chr18_+_37421418 3.903 ENSMUST00000053073.4
Pcdhb11
protocadherin beta 11
chr15_-_43869993 3.586 ENSMUST00000067469.4
Tmem74
transmembrane protein 74
chr3_-_127409014 3.556 ENSMUST00000182008.1
ENSMUST00000182711.1
ENSMUST00000182547.1
Ank2


ankyrin 2, brain


chr3_+_9403049 3.537 ENSMUST00000180874.1
ENSMUST00000181331.1
ENSMUST00000181930.1
C030034L19Rik


RIKEN cDNA C030034L19 gene


chr13_+_42680565 3.367 ENSMUST00000128646.1
Phactr1
phosphatase and actin regulator 1
chr3_-_53657339 3.345 ENSMUST00000091137.4
Frem2
Fras1 related extracellular matrix protein 2
chr16_-_60605226 3.325 ENSMUST00000068860.6
Epha6
Eph receptor A6
chr11_-_35798884 3.246 ENSMUST00000160726.2
Fbll1
fibrillarin-like 1
chr10_+_112271123 3.210 ENSMUST00000092175.2
Kcnc2
potassium voltage gated channel, Shaw-related subfamily, member 2
chrX_-_162565514 3.124 ENSMUST00000154424.1
Reps2
RALBP1 associated Eps domain containing protein 2
chr3_-_127408937 3.085 ENSMUST00000183095.1
ENSMUST00000182610.1
Ank2

ankyrin 2, brain

chr6_+_86078070 2.873 ENSMUST00000032069.5
Add2
adducin 2 (beta)
chr4_+_103619580 2.818 ENSMUST00000106827.1
Dab1
disabled 1
chr9_-_44799179 2.694 ENSMUST00000114705.1
ENSMUST00000002100.7
Tmem25

transmembrane protein 25

chr17_-_46890405 2.673 ENSMUST00000086675.3
A330017A19Rik
RIKEN cDNA A330017A19 gene
chr15_-_59082026 2.646 ENSMUST00000080371.6
Mtss1
metastasis suppressor 1
chr3_-_127409044 2.501 ENSMUST00000182704.1
Ank2
ankyrin 2, brain
chr18_+_37355271 2.483 ENSMUST00000051163.1
Pcdhb8
protocadherin beta 8
chr4_+_101550411 2.436 ENSMUST00000094953.4
ENSMUST00000106933.1
Dnajc6

DnaJ (Hsp40) homolog, subfamily C, member 6

chr7_+_24112314 2.377 ENSMUST00000120006.1
ENSMUST00000005413.3
Zfp112

zinc finger protein 112

chr18_+_38993126 2.363 ENSMUST00000097593.2
Arhgap26
Rho GTPase activating protein 26
chr3_-_127408986 2.361 ENSMUST00000182588.1
ENSMUST00000182959.1
ENSMUST00000182452.1
Ank2


ankyrin 2, brain


chr1_-_126492900 2.341 ENSMUST00000161954.1
Nckap5
NCK-associated protein 5
chr2_-_148443543 2.338 ENSMUST00000099269.3
Cd93
CD93 antigen
chr11_-_120643643 2.321 ENSMUST00000141254.1
ENSMUST00000170556.1
ENSMUST00000151876.1
ENSMUST00000026133.8
ENSMUST00000139706.1
Pycr1




pyrroline-5-carboxylate reductase 1




chr8_+_12915879 2.264 ENSMUST00000110876.2
ENSMUST00000110879.2
Mcf2l

mcf.2 transforming sequence-like

chr15_-_93595877 2.221 ENSMUST00000048982.4
Prickle1
prickle homolog 1 (Drosophila)
chr18_+_37307445 2.132 ENSMUST00000056712.2
Pcdhb4
protocadherin beta 4
chr1_+_34121250 2.132 ENSMUST00000183006.1
Dst
dystonin
chr7_+_18884679 2.067 ENSMUST00000032573.6
Pglyrp1
peptidoglycan recognition protein 1
chr2_-_45117349 2.041 ENSMUST00000176438.2
Zeb2
zinc finger E-box binding homeobox 2
chr15_-_83510793 1.958 ENSMUST00000154401.1
Ttll1
tubulin tyrosine ligase-like 1
chr14_+_66868850 1.928 ENSMUST00000100453.1
Gm5464
predicted gene 5464
chr18_+_37333853 1.819 ENSMUST00000061717.2
Pcdhb6
protocadherin beta 6
chr16_+_78301458 1.819 ENSMUST00000023572.7
Cxadr
coxsackie virus and adenovirus receptor
chr1_-_58586191 1.796 ENSMUST00000038372.7
ENSMUST00000097724.3
ENSMUST00000161000.1
ENSMUST00000161600.1
Fam126b



family with sequence similarity 126, member B



chr8_+_106603351 1.744 ENSMUST00000000312.5
ENSMUST00000167688.1
Cdh1

cadherin 1

chr16_-_87432597 1.718 ENSMUST00000039449.7
Ltn1
listerin E3 ubiquitin protein ligase 1
chr8_-_99416397 1.590 ENSMUST00000155527.1
ENSMUST00000142129.1
ENSMUST00000093249.4
ENSMUST00000142475.2
ENSMUST00000128860.1
Cdh8




cadherin 8




chr15_-_83510861 1.588 ENSMUST00000109479.1
ENSMUST00000109480.1
ENSMUST00000016897.4
Ttll1


tubulin tyrosine ligase-like 1


chr8_+_25720054 1.552 ENSMUST00000068916.8
ENSMUST00000139836.1
Ppapdc1b

phosphatidic acid phosphatase type 2 domain containing 1B

chr5_-_74531619 1.548 ENSMUST00000113542.2
ENSMUST00000072857.6
ENSMUST00000121330.1
ENSMUST00000151474.1
Scfd2



Sec1 family domain containing 2



chr2_+_119351222 1.542 ENSMUST00000028780.3
Chac1
ChaC, cation transport regulator 1
chr7_+_107370728 1.539 ENSMUST00000137663.1
ENSMUST00000073459.5
Syt9

synaptotagmin IX

chr2_-_131328982 1.495 ENSMUST00000110194.1
Rnf24
ring finger protein 24
chr5_-_36695969 1.442 ENSMUST00000031091.9
ENSMUST00000140063.1
D5Ertd579e

DNA segment, Chr 5, ERATO Doi 579, expressed

chr14_-_66868572 1.441 ENSMUST00000022629.8
Dpysl2
dihydropyrimidinase-like 2
chr1_-_126492683 1.428 ENSMUST00000162877.1
Nckap5
NCK-associated protein 5
chr1_-_165460430 1.421 ENSMUST00000027856.7
Dcaf6
DDB1 and CUL4 associated factor 6
chr6_+_125494419 1.403 ENSMUST00000181266.1
Gm26728
predicted gene, 26728
chr6_+_89643982 1.402 ENSMUST00000000828.6
ENSMUST00000101171.1
Txnrd3

thioredoxin reductase 3

chr2_-_130839683 1.368 ENSMUST00000119422.1
4930402H24Rik
RIKEN cDNA 4930402H24 gene
chr1_+_87327008 1.350 ENSMUST00000172794.1
ENSMUST00000164992.2
Gigyf2

GRB10 interacting GYF protein 2

chr11_-_61930197 1.334 ENSMUST00000108710.1
Akap10
A kinase (PRKA) anchor protein 10
chr3_-_49757257 1.318 ENSMUST00000035931.7
Pcdh18
protocadherin 18
chr14_-_75787031 1.316 ENSMUST00000022580.6
Slc25a30
solute carrier family 25, member 30
chr5_-_148399901 1.250 ENSMUST00000048116.8
Slc7a1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr9_-_20644726 1.237 ENSMUST00000148631.1
ENSMUST00000131128.1
ENSMUST00000151861.1
ENSMUST00000131343.1
ENSMUST00000086458.3
Fbxl12




F-box and leucine-rich repeat protein 12




chr16_+_96145391 1.203 ENSMUST00000023913.8
ENSMUST00000135448.1
Wrb

tryptophan rich basic protein

chr19_-_4334001 1.188 ENSMUST00000176653.1
Kdm2a
lysine (K)-specific demethylase 2A
chr3_+_108186332 1.147 ENSMUST00000050909.6
ENSMUST00000106659.2
ENSMUST00000106656.1
ENSMUST00000106661.2
Amigo1



adhesion molecule with Ig like domain 1



chr2_-_120850598 1.147 ENSMUST00000028740.4
Ttbk2
tau tubulin kinase 2
chr5_-_43981757 1.122 ENSMUST00000061299.7
Fgfbp1
fibroblast growth factor binding protein 1
chr13_-_113618549 1.078 ENSMUST00000109241.3
Snx18
sorting nexin 18
chr18_+_40258361 1.037 ENSMUST00000091927.4
Kctd16
potassium channel tetramerisation domain containing 16
chr16_+_36041184 1.030 ENSMUST00000042203.8
Wdr5b
WD repeat domain 5B
chr14_+_63606491 0.980 ENSMUST00000119973.2
Xkr6
X Kell blood group precursor related family member 6 homolog
chr16_+_35983424 0.977 ENSMUST00000173555.1
Kpna1
karyopherin (importin) alpha 1
chr11_-_96075655 0.969 ENSMUST00000090541.5
Atp5g1
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c1 (subunit 9)
chr15_-_27681498 0.931 ENSMUST00000100739.3
Fam105a
family with sequence similarity 105, member A
chr14_-_47568427 0.927 ENSMUST00000042988.6
Atg14
autophagy related 14
chr2_-_32961592 0.918 ENSMUST00000133832.1
ENSMUST00000124492.1
ENSMUST00000145578.1
ENSMUST00000127321.1
ENSMUST00000113200.1
Lrsam1




leucine rich repeat and sterile alpha motif containing 1




chr8_-_35495487 0.914 ENSMUST00000033927.6
Eri1
exoribonuclease 1
chr9_-_45906369 0.907 ENSMUST00000161187.1
Rnf214
ring finger protein 214
chr11_-_79296906 0.833 ENSMUST00000068448.2
Gm9964
predicted gene 9964
chr16_+_24721842 0.796 ENSMUST00000115314.2
Lpp
LIM domain containing preferred translocation partner in lipoma
chr5_-_114273702 0.787 ENSMUST00000144050.1
ENSMUST00000044790.5
Foxn4

forkhead box N4

chr2_+_181837854 0.783 ENSMUST00000029116.7
ENSMUST00000108754.1
Pcmtd2

protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2

chr11_+_70214105 0.767 ENSMUST00000094055.3
ENSMUST00000136328.1
ENSMUST00000126296.1
ENSMUST00000153993.2
Slc16a11



solute carrier family 16 (monocarboxylic acid transporters), member 11



chr1_+_165461037 0.752 ENSMUST00000027853.5
Mpc2
mitochondrial pyruvate carrier 2
chr1_+_87326997 0.742 ENSMUST00000027475.8
Gigyf2
GRB10 interacting GYF protein 2
chr16_-_45724600 0.717 ENSMUST00000096057.4
Tagln3
transgelin 3
chr10_+_84917616 0.698 ENSMUST00000038523.7
ENSMUST00000095385.3
Ric8b

resistance to inhibitors of cholinesterase 8 homolog B (C. elegans)

chr11_+_75486813 0.688 ENSMUST00000018449.4
ENSMUST00000102510.1
ENSMUST00000131283.1
Prpf8


pre-mRNA processing factor 8


chr7_+_126776939 0.663 ENSMUST00000038614.5
ENSMUST00000170882.1
ENSMUST00000106359.1
ENSMUST00000106357.1
ENSMUST00000145762.1
ENSMUST00000132643.1
ENSMUST00000106356.1
Ypel3






yippee-like 3 (Drosophila)






chr6_+_88724667 0.631 ENSMUST00000163271.1
Mgll
monoglyceride lipase
chr6_+_71831325 0.630 ENSMUST00000064062.6
ENSMUST00000166975.1
ENSMUST00000165331.1
ENSMUST00000114151.3
ENSMUST00000101301.3
ENSMUST00000166938.1
Immt





inner membrane protein, mitochondrial





chr8_-_47533439 0.622 ENSMUST00000039061.8
Trappc11
trafficking protein particle complex 11
chr1_-_195131536 0.602 ENSMUST00000075451.6
Cr1l
complement component (3b/4b) receptor 1-like
chr16_+_35983307 0.597 ENSMUST00000004054.6
Kpna1
karyopherin (importin) alpha 1
chr6_-_99044414 0.592 ENSMUST00000177507.1
ENSMUST00000123992.1
Foxp1

forkhead box P1

chrX_-_37104523 0.590 ENSMUST00000130324.1
Upf3b
UPF3 regulator of nonsense transcripts homolog B (yeast)
chr9_-_70141484 0.564 ENSMUST00000034749.8
Fam81a
family with sequence similarity 81, member A
chr11_+_110399115 0.557 ENSMUST00000020949.5
ENSMUST00000100260.1
Map2k6

mitogen-activated protein kinase kinase 6

chr11_-_96075581 0.553 ENSMUST00000107686.1
ENSMUST00000107684.1
Atp5g1

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c1 (subunit 9)

chr2_-_164071089 0.553 ENSMUST00000018466.3
Tomm34
translocase of outer mitochondrial membrane 34
chr14_+_65970804 0.541 ENSMUST00000138191.1
Clu
clusterin
chr8_-_22476809 0.538 ENSMUST00000163774.1
ENSMUST00000033935.8
Smim19

small integral membrane protein 19

chr11_-_116199040 0.528 ENSMUST00000066587.5
Acox1
acyl-Coenzyme A oxidase 1, palmitoyl
chr2_-_164071124 0.525 ENSMUST00000109384.3
Tomm34
translocase of outer mitochondrial membrane 34
chr11_+_60728398 0.524 ENSMUST00000018743.4
Mief2
mitochondrial elongation factor 2
chr1_+_174501796 0.505 ENSMUST00000030039.7
Fmn2
formin 2
chr6_-_86793522 0.500 ENSMUST00000001187.8
Anxa4
annexin A4
chr8_+_94386438 0.497 ENSMUST00000161576.1
Herpud1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr17_-_15564322 0.494 ENSMUST00000147532.1
Prdm9
PR domain containing 9
chr12_+_10390756 0.469 ENSMUST00000020947.5
Rdh14
retinol dehydrogenase 14 (all-trans and 9-cis)
chrX_+_166238901 0.467 ENSMUST00000112235.1
Gpm6b
glycoprotein m6b
chr4_-_101844023 0.455 ENSMUST00000106919.1
B020004J07Rik
RIKEN cDNA B020004J07 gene
chr5_-_131538687 0.447 ENSMUST00000161374.1
Auts2
autism susceptibility candidate 2
chr11_+_54303798 0.412 ENSMUST00000093106.5
Acsl6
acyl-CoA synthetase long-chain family member 6
chr11_-_59163696 0.410 ENSMUST00000137433.1
ENSMUST00000054523.5
Iba57

IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)

chr16_-_15594507 0.409 ENSMUST00000115776.1
ENSMUST00000115777.3
Ube2v2

ubiquitin-conjugating enzyme E2 variant 2

chr7_+_28437447 0.399 ENSMUST00000108292.2
ENSMUST00000108289.1
Gmfg

glia maturation factor, gamma

chr10_+_13501001 0.373 ENSMUST00000060212.6
ENSMUST00000121465.2
Fuca2

fucosidase, alpha-L- 2, plasma

chr8_+_123443288 0.368 ENSMUST00000108830.1
Def8
differentially expressed in FDCP 8
chr5_+_31526989 0.362 ENSMUST00000114533.2
ENSMUST00000117262.1
ENSMUST00000117319.1
Slc4a1ap


solute carrier family 4 (anion exchanger), member 1, adaptor protein


chr7_+_120677579 0.335 ENSMUST00000060175.6
BC030336
cDNA sequence BC030336
chr11_+_51763682 0.333 ENSMUST00000020653.5
Sar1b
SAR1 gene homolog B (S. cerevisiae)
chr2_+_16356744 0.331 ENSMUST00000114703.3
Plxdc2
plexin domain containing 2
chr14_+_65971049 0.331 ENSMUST00000128539.1
Clu
clusterin
chr1_+_166379097 0.327 ENSMUST00000027846.7
Tada1
transcriptional adaptor 1
chr7_-_126082406 0.314 ENSMUST00000073935.5
Gsg1l
GSG1-like
chr6_-_138422898 0.308 ENSMUST00000161450.1
ENSMUST00000163024.1
ENSMUST00000162185.1
Lmo3


LIM domain only 3


chr3_+_58526303 0.297 ENSMUST00000138848.1
Eif2a
eukaryotic translation initiation factor 2A
chr8_+_123442969 0.287 ENSMUST00000093049.3
ENSMUST00000065534.3
ENSMUST00000001522.3
ENSMUST00000124741.1
ENSMUST00000108832.1
ENSMUST00000132063.1
ENSMUST00000128424.1
Def8






differentially expressed in FDCP 8






chr11_-_78245942 0.269 ENSMUST00000002121.4
Supt6
suppressor of Ty 6
chr5_-_31526693 0.265 ENSMUST00000118874.1
ENSMUST00000117642.1
ENSMUST00000065388.4
Supt7l


suppressor of Ty 7-like


chr8_+_94386486 0.256 ENSMUST00000034220.7
Herpud1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr17_-_33781535 0.255 ENSMUST00000002360.9
Angptl4
angiopoietin-like 4
chr11_+_101070012 0.226 ENSMUST00000001802.9
Naglu
alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)
chr19_-_4042165 0.220 ENSMUST00000042700.9
Gstp2
glutathione S-transferase, pi 2
chrX_+_94724569 0.193 ENSMUST00000101388.2
Zxdb
zinc finger, X-linked, duplicated B
chr5_+_32458974 0.191 ENSMUST00000015100.8
Ppp1cb
protein phosphatase 1, catalytic subunit, beta isoform
chr2_-_126876117 0.186 ENSMUST00000028843.5
Trpm7
transient receptor potential cation channel, subfamily M, member 7
chr1_-_39651165 0.138 ENSMUST00000053355.4
Creg2
cellular repressor of E1A-stimulated genes 2
chr11_+_69846374 0.117 ENSMUST00000108632.1
Plscr3
phospholipid scramblase 3
chr10_+_127195240 0.109 ENSMUST00000181578.1
F420014N23Rik
RIKEN cDNA F420014N23 gene
chr15_-_59374149 0.080 ENSMUST00000022976.4
E430025E21Rik
RIKEN cDNA E430025E21 gene
chr14_-_21052120 0.079 ENSMUST00000130370.1
ENSMUST00000022371.3
Ap3m1

adaptor-related protein complex 3, mu 1 subunit

chr1_+_173673651 0.075 ENSMUST00000085876.4
Pydc3
pyrin domain containing 3
chr2_+_23069210 0.071 ENSMUST00000155602.1
Acbd5
acyl-Coenzyme A binding domain containing 5
chr7_-_31150981 0.064 ENSMUST00000085636.6
ENSMUST00000001280.7
Gramd1a

GRAM domain containing 1A

chr6_+_71322775 0.040 ENSMUST00000065248.7
Cd8b1
CD8 antigen, beta chain 1
chr3_-_86142684 0.008 ENSMUST00000029722.6
Rps3a1
ribosomal protein S3A1
chr11_+_98809787 0.006 ENSMUST00000169695.1
Casc3
cancer susceptibility candidate 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 11.5 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.9 2.8 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.9 2.6 GO:0034334 adherens junction maintenance(GO:0034334)
0.9 5.2 GO:0019695 choline metabolic process(GO:0019695)
0.7 2.2 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.7 2.1 GO:0051715 cytolysis in other organism(GO:0051715)
0.6 3.2 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
0.6 1.8 GO:0086042 cardiac muscle cell-cardiac muscle cell adhesion(GO:0086042)
0.6 5.9 GO:0051901 positive regulation of mitochondrial depolarization(GO:0051901)
0.6 6.2 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
0.4 2.4 GO:0072318 clathrin coat disassembly(GO:0072318)
0.4 3.5 GO:0018095 protein polyglutamylation(GO:0018095)
0.4 1.6 GO:0099527 postsynapse to nucleus signaling pathway(GO:0099527)
0.4 1.5 GO:0006751 glutathione catabolic process(GO:0006751)
0.3 1.7 GO:0060066 oviduct development(GO:0060066) response to indole-3-methanol(GO:0071680) cellular response to indole-3-methanol(GO:0071681)
0.3 2.0 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.3 2.3 GO:0006561 proline biosynthetic process(GO:0006561)
0.3 3.2 GO:1903818 positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.2 0.9 GO:0016240 autophagosome docking(GO:0016240)
0.2 0.9 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.2 5.0 GO:0045475 locomotor rhythm(GO:0045475)
0.2 0.4 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
0.2 1.1 GO:0036089 cleavage furrow formation(GO:0036089)
0.2 0.8 GO:1901475 pyruvate transmembrane transport(GO:1901475)
0.2 1.1 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.2 2.9 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.2 0.5 GO:0070649 meiotic chromosome movement towards spindle pole(GO:0016344) formin-nucleated actin cable assembly(GO:0070649)
0.2 0.7 GO:2000774 positive regulation of cellular senescence(GO:2000774)
0.2 0.5 GO:0010845 positive regulation of reciprocal meiotic recombination(GO:0010845)
0.2 1.2 GO:0071816 tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.1 1.2 GO:0033184 positive regulation of histone ubiquitination(GO:0033184)
0.1 0.4 GO:0042275 error-free postreplication DNA repair(GO:0042275)
0.1 0.5 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.1 0.8 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.1 0.7 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.1 8.4 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 2.1 GO:0008090 retrograde axonal transport(GO:0008090)
0.1 0.9 GO:0031125 rRNA 3'-end processing(GO:0031125)
0.1 2.3 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.1 1.3 GO:0015809 arginine transport(GO:0015809)
0.1 0.5 GO:2000483 negative regulation of interleukin-8 secretion(GO:2000483)
0.1 1.1 GO:1990403 embryonic brain development(GO:1990403)
0.1 0.6 GO:0032308 positive regulation of prostaglandin secretion(GO:0032308)
0.1 2.1 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571)
0.1 1.4 GO:0014049 positive regulation of glutamate secretion(GO:0014049)
0.1 0.5 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.1 0.6 GO:2000258 negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.1 0.6 GO:0061635 regulation of protein complex stability(GO:0061635)
0.1 0.4 GO:0010747 positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747)
0.1 0.5 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.1 0.8 GO:0035881 amacrine cell differentiation(GO:0035881)
0.1 0.6 GO:0061470 interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619)
0.1 1.5 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.1 0.7 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.1 0.4 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
0.1 1.5 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.1 0.3 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.0 0.3 GO:1990928 response to amino acid starvation(GO:1990928)
0.0 0.5 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.0 0.4 GO:0006004 fucose metabolic process(GO:0006004)
0.0 0.2 GO:0016340 calcium-dependent cell-matrix adhesion(GO:0016340)
0.0 1.4 GO:0000305 response to oxygen radical(GO:0000305)
0.0 0.5 GO:0042572 retinol metabolic process(GO:0042572)
0.0 6.0 GO:0007416 synapse assembly(GO:0007416)
0.0 1.5 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.6 GO:0042407 cristae formation(GO:0042407)
0.0 0.3 GO:0051004 regulation of lipoprotein lipase activity(GO:0051004)
0.0 3.4 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.0 0.2 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.0 0.4 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.3 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0 2.8 GO:0006338 chromatin remodeling(GO:0006338)
0.0 0.6 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 0.3 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.0 0.5 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 0.1 GO:0030242 pexophagy(GO:0030242)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.1 GO:0031673 H zone(GO:0031673)
0.5 3.2 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.5 6.8 GO:0043083 synaptic cleft(GO:0043083)
0.4 5.9 GO:0043203 axon hillock(GO:0043203)
0.4 11.5 GO:0031430 M band(GO:0031430)
0.3 0.9 GO:0097629 extrinsic component of omegasome membrane(GO:0097629)
0.3 2.9 GO:0008290 F-actin capping protein complex(GO:0008290)
0.2 9.1 GO:0032809 neuronal cell body membrane(GO:0032809)
0.2 4.0 GO:0016514 SWI/SNF complex(GO:0016514)
0.2 6.2 GO:0055038 recycling endosome membrane(GO:0055038)
0.2 0.8 GO:1990037 Lewy body core(GO:1990037)
0.1 1.7 GO:0016600 flotillin complex(GO:0016600)
0.1 0.4 GO:0031372 UBC13-MMS2 complex(GO:0031372)
0.1 2.1 GO:1990635 proximal dendrite(GO:1990635)
0.1 0.9 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.1 1.5 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 1.8 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 0.2 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.1 0.6 GO:0061617 MICOS complex(GO:0061617)
0.1 0.7 GO:0097418 neurofibrillary tangle(GO:0097418)
0.1 0.8 GO:0031045 dense core granule(GO:0031045)
0.0 0.7 GO:0043196 varicosity(GO:0043196)
0.0 0.6 GO:0030008 TRAPP complex(GO:0030008)
0.0 1.4 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 3.3 GO:0005604 basement membrane(GO:0005604)
0.0 0.3 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0 0.7 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.8 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.6 GO:0030914 STAGA complex(GO:0030914)
0.0 0.2 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 1.1 GO:0035869 ciliary transition zone(GO:0035869)
0.0 3.3 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 5.1 GO:0031967 organelle envelope(GO:0031967)
0.0 0.3 GO:0032279 asymmetric synapse(GO:0032279)
0.0 0.6 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 1.4 GO:0005643 nuclear pore(GO:0005643)
0.0 1.0 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.3 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 2.0 GO:0005741 mitochondrial outer membrane(GO:0005741)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 5.2 GO:0004104 cholinesterase activity(GO:0004104) choline binding(GO:0033265)
0.9 4.7 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.9 3.5 GO:0070740 tubulin-glutamic acid ligase activity(GO:0070740)
0.6 2.3 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.5 2.1 GO:0042834 peptidoglycan binding(GO:0042834)
0.4 1.8 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.3 2.3 GO:0001849 complement component C1q binding(GO:0001849)
0.3 1.5 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.3 0.9 GO:0071207 histone pre-mRNA stem-loop binding(GO:0071207)
0.3 5.9 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.2 14.4 GO:0030507 spectrin binding(GO:0030507)
0.2 1.4 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.2 0.7 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.2 3.2 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.2 1.2 GO:0045322 unmethylated CpG binding(GO:0045322)
0.2 0.8 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.2 3.2 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.2 3.3 GO:0005003 ephrin receptor activity(GO:0005003)
0.2 0.8 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.2 1.3 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.1 6.2 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 1.7 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 2.3 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 0.4 GO:0015928 alpha-L-fucosidase activity(GO:0004560) fucosidase activity(GO:0015928)
0.1 3.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 1.1 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.1 2.6 GO:0003785 actin monomer binding(GO:0003785)
0.1 1.5 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 0.5 GO:0016401 palmitoyl-CoA oxidase activity(GO:0016401)
0.1 2.1 GO:0070064 proline-rich region binding(GO:0070064)
0.1 1.1 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.1 2.8 GO:0042169 SH2 domain binding(GO:0042169)
0.1 1.6 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 2.0 GO:0070412 R-SMAD binding(GO:0070412)
0.0 2.0 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.5 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.5 GO:0008106 alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.0 0.7 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.3 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.0 0.5 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.6 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 1.3 GO:0051018 protein kinase A binding(GO:0051018)
0.0 1.1 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 1.4 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.4 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.0 1.1 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 0.8 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 2.4 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.2 GO:0015929 hexosaminidase activity(GO:0015929)
0.0 0.7 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 6.3 GO:0005509 calcium ion binding(GO:0005509)
0.0 1.4 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds(GO:0016810)
0.0 3.0 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 0.6 GO:0004402 histone acetyltransferase activity(GO:0004402)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.3 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 5.2 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.1 6.9 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 2.8 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 1.7 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 2.3 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 2.3 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 1.6 PID_PI3KCI_AKT_PATHWAY Class I PI3K signaling events mediated by Akt
0.0 0.6 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 2.1 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 2.6 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 2.2 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.3 PID_MYC_PATHWAY C-MYC pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.7 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.2 5.2 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.2 7.9 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 1.6 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 1.8 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 1.5 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 1.4 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 2.4 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 1.6 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.3 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.8 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.7 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.6 REACTOME_ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.0 0.5 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.3 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.4 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.6 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.0 0.7 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 1.3 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 2.0 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY Genes involved in Generic Transcription Pathway