Motif ID: Ddit3

Z-value: 0.707


Transcription factors associated with Ddit3:

Gene SymbolEntrez IDGene Name
Ddit3 ENSMUSG00000025408.9 Ddit3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ddit3mm10_v2_chr10_+_127290774_1272908030.009.8e-01Click!


Activity profile for motif Ddit3.

activity profile for motif Ddit3


Sorted Z-values histogram for motif Ddit3

Sorted Z-values for motif Ddit3



Network of associatons between targets according to the STRING database.



First level regulatory network of Ddit3

PNG image of the network

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Top targets:


Showing 1 to 20 of 153 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_109823585 7.505 ENSMUST00000161582.1
 Nav3
neuron navigator 3
chr19_-_59076069 6.389 ENSMUST00000047511.7
ENSMUST00000163821.1
 4930506M07Rik

RIKEN cDNA 4930506M07 gene

chr15_-_66948419 6.202 ENSMUST00000167817.1
 Ndrg1
N-myc downstream regulated gene 1
chrX_+_103422010 6.186 ENSMUST00000182089.1
 Gm26992
predicted gene, 26992
chr9_-_121495678 5.904 ENSMUST00000035120.4
 Cck
cholecystokinin
chr5_+_137288273 5.217 ENSMUST00000024099.4
ENSMUST00000085934.3
 Ache

acetylcholinesterase

chr6_+_21215472 4.740 ENSMUST00000081542.5
 Kcnd2
potassium voltage-gated channel, Shal-related family, member 2
chr5_+_137553517 4.031 ENSMUST00000136088.1
ENSMUST00000139395.1
ENSMUST00000136565.1
ENSMUST00000149292.1
ENSMUST00000125489.1
 Actl6b




actin-like 6B




chr18_+_37421418 3.903 ENSMUST00000053073.4
 Pcdhb11
protocadherin beta 11
chr15_-_43869993 3.586 ENSMUST00000067469.4
 Tmem74
transmembrane protein 74
chr3_-_127409014 3.556 ENSMUST00000182008.1
ENSMUST00000182711.1
ENSMUST00000182547.1
 Ank2


ankyrin 2, brain


chr3_+_9403049 3.537 ENSMUST00000180874.1
ENSMUST00000181331.1
ENSMUST00000181930.1
 C030034L19Rik


RIKEN cDNA C030034L19 gene


chr13_+_42680565 3.367 ENSMUST00000128646.1
 Phactr1
phosphatase and actin regulator 1
chr3_-_53657339 3.345 ENSMUST00000091137.4
 Frem2
Fras1 related extracellular matrix protein 2
chr16_-_60605226 3.325 ENSMUST00000068860.6
 Epha6
Eph receptor A6
chr11_-_35798884 3.246 ENSMUST00000160726.2
 Fbll1
fibrillarin-like 1
chr10_+_112271123 3.210 ENSMUST00000092175.2
 Kcnc2
potassium voltage gated channel, Shaw-related subfamily, member 2
chrX_-_162565514 3.124 ENSMUST00000154424.1
 Reps2
RALBP1 associated Eps domain containing protein 2
chr3_-_127408937 3.085 ENSMUST00000183095.1
ENSMUST00000182610.1
 Ank2

ankyrin 2, brain

chr6_+_86078070 2.873 ENSMUST00000032069.5
 Add2
adducin 2 (beta)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 11.5 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.1 8.4 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.6 6.2 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
0.0 6.0 GO:0007416 synapse assembly(GO:0007416)
0.6 5.9 GO:0051901 positive regulation of mitochondrial depolarization(GO:0051901)
0.9 5.2 GO:0019695 choline metabolic process(GO:0019695)
0.2 5.0 GO:0045475 locomotor rhythm(GO:0045475)
0.4 3.5 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 3.4 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.6 3.2 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
0.3 3.2 GO:1903818 positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.2 2.9 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.9 2.8 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.0 2.8 GO:0006338 chromatin remodeling(GO:0006338)
0.9 2.6 GO:0034334 adherens junction maintenance(GO:0034334)
0.4 2.4 GO:0072318 clathrin coat disassembly(GO:0072318)
0.3 2.3 GO:0006561 proline biosynthetic process(GO:0006561)
0.1 2.3 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.7 2.2 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.7 2.1 GO:0051715 cytolysis in other organism(GO:0051715)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 11.5 GO:0031430 M band(GO:0031430)
0.2 9.1 GO:0032809 neuronal cell body membrane(GO:0032809)
0.5 6.8 GO:0043083 synaptic cleft(GO:0043083)
0.2 6.2 GO:0055038 recycling endosome membrane(GO:0055038)
0.4 5.9 GO:0043203 axon hillock(GO:0043203)
0.0 5.1 GO:0031967 organelle envelope(GO:0031967)
0.2 4.0 GO:0016514 SWI/SNF complex(GO:0016514)
0.0 3.3 GO:0005604 basement membrane(GO:0005604)
0.0 3.3 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.5 3.2 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.3 2.9 GO:0008290 F-actin capping protein complex(GO:0008290)
0.5 2.1 GO:0031673 H zone(GO:0031673)
0.1 2.1 GO:1990635 proximal dendrite(GO:1990635)
0.0 2.0 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.1 1.8 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 1.7 GO:0016600 flotillin complex(GO:0016600)
0.1 1.5 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 1.4 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 1.4 GO:0005643 nuclear pore(GO:0005643)
0.0 1.1 GO:0035869 ciliary transition zone(GO:0035869)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 14.4 GO:0030507 spectrin binding(GO:0030507)
0.0 6.3 GO:0005509 calcium ion binding(GO:0005509)
0.1 6.2 GO:0043015 gamma-tubulin binding(GO:0043015)
0.3 5.9 GO:0005184 neuropeptide hormone activity(GO:0005184)
1.3 5.2 GO:0004104 cholinesterase activity(GO:0004104) choline binding(GO:0033265)
0.9 4.7 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.9 3.5 GO:0070740 tubulin-glutamic acid ligase activity(GO:0070740)
0.1 3.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.2 3.3 GO:0005003 ephrin receptor activity(GO:0005003)
0.2 3.2 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.2 3.2 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 3.0 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 2.8 GO:0042169 SH2 domain binding(GO:0042169)
0.1 2.6 GO:0003785 actin monomer binding(GO:0003785)
0.0 2.4 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.6 2.3 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.3 2.3 GO:0001849 complement component C1q binding(GO:0001849)
0.1 2.3 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.5 2.1 GO:0042834 peptidoglycan binding(GO:0042834)
0.1 2.1 GO:0070064 proline-rich region binding(GO:0070064)

Gene overrepresentation in C2:CP category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.9 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 5.2 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.1 3.3 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 2.8 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 2.6 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 2.3 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 2.3 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 2.2 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.1 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 1.7 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 1.6 PID_PI3KCI_AKT_PATHWAY Class I PI3K signaling events mediated by Akt
0.0 0.6 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 0.3 PID_MYC_PATHWAY C-MYC pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.9 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 5.2 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.1 2.4 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 2.0 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY Genes involved in Generic Transcription Pathway
0.1 1.8 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.2 1.7 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 1.6 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 1.6 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 1.5 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 1.4 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 1.3 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 1.3 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.8 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.7 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.7 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.6 REACTOME_ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.0 0.6 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.0 0.5 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.4 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.3 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport