Motif ID: Ddit3
Z-value: 0.707
Transcription factors associated with Ddit3:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Ddit3 | ENSMUSG00000025408.9 | Ddit3 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Ddit3 | mm10_v2_chr10_+_127290774_127290803 | 0.00 | 9.8e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.3 | 11.5 | GO:0036371 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
0.9 | 2.8 | GO:0021577 | hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589) |
0.9 | 2.6 | GO:0034334 | adherens junction maintenance(GO:0034334) |
0.9 | 5.2 | GO:0019695 | choline metabolic process(GO:0019695) |
0.7 | 2.2 | GO:0051892 | negative regulation of cardioblast differentiation(GO:0051892) |
0.7 | 2.1 | GO:0051715 | cytolysis in other organism(GO:0051715) |
0.6 | 3.2 | GO:0018364 | peptidyl-glutamine methylation(GO:0018364) |
0.6 | 1.8 | GO:0086042 | cardiac muscle cell-cardiac muscle cell adhesion(GO:0086042) |
0.6 | 5.9 | GO:0051901 | positive regulation of mitochondrial depolarization(GO:0051901) |
0.6 | 6.2 | GO:0090232 | positive regulation of spindle checkpoint(GO:0090232) |
0.4 | 2.4 | GO:0072318 | clathrin coat disassembly(GO:0072318) |
0.4 | 3.5 | GO:0018095 | protein polyglutamylation(GO:0018095) |
0.4 | 1.6 | GO:0099527 | postsynapse to nucleus signaling pathway(GO:0099527) |
0.4 | 1.5 | GO:0006751 | glutathione catabolic process(GO:0006751) |
0.3 | 1.7 | GO:0060066 | oviduct development(GO:0060066) response to indole-3-methanol(GO:0071680) cellular response to indole-3-methanol(GO:0071681) |
0.3 | 2.0 | GO:1903056 | positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056) |
0.3 | 2.3 | GO:0006561 | proline biosynthetic process(GO:0006561) |
0.3 | 3.2 | GO:1903818 | positive regulation of voltage-gated potassium channel activity(GO:1903818) |
0.2 | 0.9 | GO:0016240 | autophagosome docking(GO:0016240) |
0.2 | 0.9 | GO:0070086 | ubiquitin-dependent endocytosis(GO:0070086) |
0.2 | 5.0 | GO:0045475 | locomotor rhythm(GO:0045475) |
0.2 | 0.4 | GO:2000620 | positive regulation of histone H4-K16 acetylation(GO:2000620) |
0.2 | 1.1 | GO:0036089 | cleavage furrow formation(GO:0036089) |
0.2 | 0.8 | GO:1901475 | pyruvate transmembrane transport(GO:1901475) |
0.2 | 1.1 | GO:0045743 | positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743) |
0.2 | 2.9 | GO:0050901 | leukocyte tethering or rolling(GO:0050901) |
0.2 | 0.5 | GO:0070649 | meiotic chromosome movement towards spindle pole(GO:0016344) formin-nucleated actin cable assembly(GO:0070649) |
0.2 | 0.7 | GO:2000774 | positive regulation of cellular senescence(GO:2000774) |
0.2 | 0.5 | GO:0010845 | positive regulation of reciprocal meiotic recombination(GO:0010845) |
0.2 | 1.2 | GO:0071816 | tail-anchored membrane protein insertion into ER membrane(GO:0071816) |
0.1 | 1.2 | GO:0033184 | positive regulation of histone ubiquitination(GO:0033184) |
0.1 | 0.4 | GO:0042275 | error-free postreplication DNA repair(GO:0042275) |
0.1 | 0.5 | GO:0033540 | fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540) |
0.1 | 0.8 | GO:1903071 | positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071) |
0.1 | 0.7 | GO:1902998 | macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
0.1 | 8.4 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
0.1 | 2.1 | GO:0008090 | retrograde axonal transport(GO:0008090) |
0.1 | 0.9 | GO:0031125 | rRNA 3'-end processing(GO:0031125) |
0.1 | 2.3 | GO:0035025 | positive regulation of Rho protein signal transduction(GO:0035025) |
0.1 | 1.3 | GO:0015809 | arginine transport(GO:0015809) |
0.1 | 0.5 | GO:2000483 | negative regulation of interleukin-8 secretion(GO:2000483) |
0.1 | 1.1 | GO:1990403 | embryonic brain development(GO:1990403) |
0.1 | 0.6 | GO:0032308 | positive regulation of prostaglandin secretion(GO:0032308) |
0.1 | 2.1 | GO:0031571 | mitotic G1 DNA damage checkpoint(GO:0031571) |
0.1 | 1.4 | GO:0014049 | positive regulation of glutamate secretion(GO:0014049) |
0.1 | 0.5 | GO:2000124 | regulation of endocannabinoid signaling pathway(GO:2000124) |
0.1 | 0.6 | GO:2000258 | negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258) |
0.1 | 0.6 | GO:0061635 | regulation of protein complex stability(GO:0061635) |
0.1 | 0.4 | GO:0010747 | positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747) |
0.1 | 0.5 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
0.1 | 0.8 | GO:0035881 | amacrine cell differentiation(GO:0035881) |
0.1 | 0.6 | GO:0061470 | interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619) |
0.1 | 1.5 | GO:0045956 | positive regulation of calcium ion-dependent exocytosis(GO:0045956) |
0.1 | 0.7 | GO:0000244 | spliceosomal tri-snRNP complex assembly(GO:0000244) |
0.1 | 0.4 | GO:0034316 | negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) |
0.1 | 1.5 | GO:0015991 | ATP hydrolysis coupled proton transport(GO:0015991) |
0.1 | 0.3 | GO:0061086 | negative regulation of histone H3-K27 methylation(GO:0061086) |
0.0 | 0.3 | GO:1990928 | response to amino acid starvation(GO:1990928) |
0.0 | 0.5 | GO:0032464 | positive regulation of protein homooligomerization(GO:0032464) |
0.0 | 0.4 | GO:0006004 | fucose metabolic process(GO:0006004) |
0.0 | 0.2 | GO:0016340 | calcium-dependent cell-matrix adhesion(GO:0016340) |
0.0 | 1.4 | GO:0000305 | response to oxygen radical(GO:0000305) |
0.0 | 0.5 | GO:0042572 | retinol metabolic process(GO:0042572) |
0.0 | 6.0 | GO:0007416 | synapse assembly(GO:0007416) |
0.0 | 1.5 | GO:0006904 | vesicle docking involved in exocytosis(GO:0006904) |
0.0 | 0.6 | GO:0042407 | cristae formation(GO:0042407) |
0.0 | 0.3 | GO:0051004 | regulation of lipoprotein lipase activity(GO:0051004) |
0.0 | 3.4 | GO:0043149 | contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149) |
0.0 | 0.2 | GO:0005981 | regulation of glycogen catabolic process(GO:0005981) |
0.0 | 0.4 | GO:0016226 | iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163) |
0.0 | 0.3 | GO:2000311 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311) |
0.0 | 2.8 | GO:0006338 | chromatin remodeling(GO:0006338) |
0.0 | 0.6 | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184) |
0.0 | 0.3 | GO:0051457 | maintenance of protein location in nucleus(GO:0051457) |
0.0 | 0.5 | GO:0051865 | protein autoubiquitination(GO:0051865) |
0.0 | 0.1 | GO:0030242 | pexophagy(GO:0030242) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 2.1 | GO:0031673 | H zone(GO:0031673) |
0.5 | 3.2 | GO:0031428 | box C/D snoRNP complex(GO:0031428) |
0.5 | 6.8 | GO:0043083 | synaptic cleft(GO:0043083) |
0.4 | 5.9 | GO:0043203 | axon hillock(GO:0043203) |
0.4 | 11.5 | GO:0031430 | M band(GO:0031430) |
0.3 | 0.9 | GO:0097629 | extrinsic component of omegasome membrane(GO:0097629) |
0.3 | 2.9 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
0.2 | 9.1 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
0.2 | 4.0 | GO:0016514 | SWI/SNF complex(GO:0016514) |
0.2 | 6.2 | GO:0055038 | recycling endosome membrane(GO:0055038) |
0.2 | 0.8 | GO:1990037 | Lewy body core(GO:1990037) |
0.1 | 1.7 | GO:0016600 | flotillin complex(GO:0016600) |
0.1 | 0.4 | GO:0031372 | UBC13-MMS2 complex(GO:0031372) |
0.1 | 2.1 | GO:1990635 | proximal dendrite(GO:1990635) |
0.1 | 0.9 | GO:0071204 | histone pre-mRNA 3'end processing complex(GO:0071204) |
0.1 | 1.5 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
0.1 | 1.8 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
0.1 | 0.2 | GO:0097057 | TRAF2-GSTP1 complex(GO:0097057) |
0.1 | 0.6 | GO:0061617 | MICOS complex(GO:0061617) |
0.1 | 0.7 | GO:0097418 | neurofibrillary tangle(GO:0097418) |
0.1 | 0.8 | GO:0031045 | dense core granule(GO:0031045) |
0.0 | 0.7 | GO:0043196 | varicosity(GO:0043196) |
0.0 | 0.6 | GO:0030008 | TRAPP complex(GO:0030008) |
0.0 | 1.4 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
0.0 | 3.3 | GO:0005604 | basement membrane(GO:0005604) |
0.0 | 0.3 | GO:0005850 | eukaryotic translation initiation factor 2 complex(GO:0005850) |
0.0 | 0.7 | GO:0005682 | U5 snRNP(GO:0005682) |
0.0 | 0.8 | GO:0031305 | integral component of mitochondrial inner membrane(GO:0031305) |
0.0 | 0.6 | GO:0030914 | STAGA complex(GO:0030914) |
0.0 | 0.2 | GO:0072357 | PTW/PP1 phosphatase complex(GO:0072357) |
0.0 | 1.1 | GO:0035869 | ciliary transition zone(GO:0035869) |
0.0 | 3.3 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
0.0 | 5.1 | GO:0031967 | organelle envelope(GO:0031967) |
0.0 | 0.3 | GO:0032279 | asymmetric synapse(GO:0032279) |
0.0 | 0.6 | GO:0035145 | exon-exon junction complex(GO:0035145) |
0.0 | 1.4 | GO:0005643 | nuclear pore(GO:0005643) |
0.0 | 1.0 | GO:0042734 | presynaptic membrane(GO:0042734) |
0.0 | 0.3 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
0.0 | 2.0 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.3 | 5.2 | GO:0004104 | cholinesterase activity(GO:0004104) choline binding(GO:0033265) |
0.9 | 4.7 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
0.9 | 3.5 | GO:0070740 | tubulin-glutamic acid ligase activity(GO:0070740) |
0.6 | 2.3 | GO:0004735 | pyrroline-5-carboxylate reductase activity(GO:0004735) |
0.5 | 2.1 | GO:0042834 | peptidoglycan binding(GO:0042834) |
0.4 | 1.8 | GO:0086080 | protein binding involved in heterotypic cell-cell adhesion(GO:0086080) |
0.3 | 2.3 | GO:0001849 | complement component C1q binding(GO:0001849) |
0.3 | 1.5 | GO:0003839 | gamma-glutamylcyclotransferase activity(GO:0003839) |
0.3 | 0.9 | GO:0071207 | histone pre-mRNA stem-loop binding(GO:0071207) |
0.3 | 5.9 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
0.2 | 14.4 | GO:0030507 | spectrin binding(GO:0030507) |
0.2 | 1.4 | GO:0004791 | thioredoxin-disulfide reductase activity(GO:0004791) |
0.2 | 0.7 | GO:0000386 | second spliceosomal transesterification activity(GO:0000386) |
0.2 | 3.2 | GO:0008649 | rRNA methyltransferase activity(GO:0008649) |
0.2 | 1.2 | GO:0045322 | unmethylated CpG binding(GO:0045322) |
0.2 | 0.8 | GO:0050833 | pyruvate transmembrane transporter activity(GO:0050833) |
0.2 | 3.2 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
0.2 | 3.3 | GO:0005003 | ephrin receptor activity(GO:0005003) |
0.2 | 0.8 | GO:0004719 | protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719) |
0.2 | 1.3 | GO:0015181 | arginine transmembrane transporter activity(GO:0015181) |
0.1 | 6.2 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
0.1 | 1.7 | GO:0045294 | alpha-catenin binding(GO:0045294) |
0.1 | 2.3 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
0.1 | 0.4 | GO:0015928 | alpha-L-fucosidase activity(GO:0004560) fucosidase activity(GO:0015928) |
0.1 | 3.4 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
0.1 | 1.1 | GO:0017134 | fibroblast growth factor binding(GO:0017134) |
0.1 | 2.6 | GO:0003785 | actin monomer binding(GO:0003785) |
0.1 | 1.5 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
0.1 | 0.5 | GO:0016401 | palmitoyl-CoA oxidase activity(GO:0016401) |
0.1 | 2.1 | GO:0070064 | proline-rich region binding(GO:0070064) |
0.1 | 1.1 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
0.1 | 2.8 | GO:0042169 | SH2 domain binding(GO:0042169) |
0.1 | 1.6 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
0.1 | 2.0 | GO:0070412 | R-SMAD binding(GO:0070412) |
0.0 | 2.0 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
0.0 | 0.5 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
0.0 | 0.5 | GO:0008106 | alcohol dehydrogenase (NADP+) activity(GO:0008106) |
0.0 | 0.7 | GO:0051787 | misfolded protein binding(GO:0051787) |
0.0 | 0.3 | GO:0000990 | transcription factor activity, core RNA polymerase binding(GO:0000990) |
0.0 | 0.5 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
0.0 | 0.6 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
0.0 | 1.3 | GO:0051018 | protein kinase A binding(GO:0051018) |
0.0 | 1.1 | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding(GO:0005546) |
0.0 | 1.4 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
0.0 | 0.4 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
0.0 | 1.1 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
0.0 | 0.8 | GO:0008028 | monocarboxylic acid transmembrane transporter activity(GO:0008028) |
0.0 | 2.4 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
0.0 | 0.2 | GO:0015929 | hexosaminidase activity(GO:0015929) |
0.0 | 0.7 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
0.0 | 6.3 | GO:0005509 | calcium ion binding(GO:0005509) |
0.0 | 1.4 | GO:0016810 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds(GO:0016810) |
0.0 | 3.0 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
0.0 | 0.6 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 3.3 | PID_EPHA_FWDPATHWAY | EPHA forward signaling |
0.1 | 5.2 | PID_ATF2_PATHWAY | ATF-2 transcription factor network |
0.1 | 6.9 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
0.1 | 2.8 | PID_LIS1_PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
0.1 | 1.7 | PID_NECTIN_PATHWAY | Nectin adhesion pathway |
0.0 | 2.3 | PID_FAK_PATHWAY | Signaling events mediated by focal adhesion kinase |
0.0 | 2.3 | PID_TRKR_PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
0.0 | 1.6 | PID_PI3KCI_AKT_PATHWAY | Class I PI3K signaling events mediated by Akt |
0.0 | 0.6 | PID_ANTHRAX_PATHWAY | Cellular roles of Anthrax toxin |
0.0 | 2.1 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
0.0 | 2.6 | PID_HEDGEHOG_GLI_PATHWAY | Hedgehog signaling events mediated by Gli proteins |
0.0 | 2.2 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
0.0 | 0.3 | PID_MYC_PATHWAY | C-MYC pathway |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 1.7 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
0.2 | 5.2 | REACTOME_SYNTHESIS_OF_PC | Genes involved in Synthesis of PC |
0.2 | 7.9 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
0.1 | 1.6 | REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
0.1 | 1.8 | REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
0.1 | 1.5 | REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
0.1 | 1.4 | REACTOME_CRMPS_IN_SEMA3A_SIGNALING | Genes involved in CRMPs in Sema3A signaling |
0.1 | 2.4 | REACTOME_LYSOSOME_VESICLE_BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
0.1 | 1.6 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
0.0 | 1.3 | REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
0.0 | 0.8 | REACTOME_ACTIVATION_OF_GENES_BY_ATF4 | Genes involved in Activation of Genes by ATF4 |
0.0 | 0.7 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
0.0 | 0.6 | REACTOME_ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION | Genes involved in activated TAK1 mediates p38 MAPK activation |
0.0 | 0.5 | REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
0.0 | 0.3 | REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
0.0 | 0.4 | REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
0.0 | 0.6 | REACTOME_MRNA_3_END_PROCESSING | Genes involved in mRNA 3'-end processing |
0.0 | 0.7 | REACTOME_MRNA_SPLICING_MINOR_PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
0.0 | 1.3 | REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
0.0 | 2.0 | REACTOME_GENERIC_TRANSCRIPTION_PATHWAY | Genes involved in Generic Transcription Pathway |