Motif ID: Dlx1

Z-value: 0.908


Transcription factors associated with Dlx1:

Gene SymbolEntrez IDGene Name
Dlx1 ENSMUSG00000041911.3 Dlx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dlx1mm10_v2_chr2_+_71529085_715291100.172.1e-01Click!


Activity profile for motif Dlx1.

activity profile for motif Dlx1


Sorted Z-values histogram for motif Dlx1

Sorted Z-values for motif Dlx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Dlx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_121953213 5.629 ENSMUST00000037958.7
ENSMUST00000128366.1
 Arhgap29

Rho GTPase activating protein 29

chr4_-_14621805 5.012 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr6_-_36811361 4.883 ENSMUST00000101534.1
 Ptn
pleiotrophin
chr8_+_66386292 4.552 ENSMUST00000039540.5
ENSMUST00000110253.2
 March1

membrane-associated ring finger (C3HC4) 1

chr5_+_107403496 4.543 ENSMUST00000049146.5
 Ephx4
epoxide hydrolase 4
chr7_-_140154712 4.540 ENSMUST00000059241.7
 Sprn
shadow of prion protein
chr15_-_8710734 4.515 ENSMUST00000005493.7
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr14_+_80000292 4.250 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr12_+_84069325 4.189 ENSMUST00000046422.4
ENSMUST00000072505.4
 Acot5

acyl-CoA thioesterase 5

chr11_-_42182924 4.157 ENSMUST00000020707.5
ENSMUST00000132971.1
 Gabra1

gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1

chr15_-_8710409 3.817 ENSMUST00000157065.1
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr5_+_66968416 3.729 ENSMUST00000038188.7
 Limch1
LIM and calponin homology domains 1
chr4_-_138396438 3.725 ENSMUST00000105032.2
 Fam43b
family with sequence similarity 43, member B
chr4_+_102570065 3.714 ENSMUST00000097950.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr15_-_37458523 3.628 ENSMUST00000116445.2
 Ncald
neurocalcin delta
chr13_+_94083490 3.606 ENSMUST00000156071.1
 Lhfpl2
lipoma HMGIC fusion partner-like 2
chr19_-_11604828 3.560 ENSMUST00000025582.4
 Ms4a6d
membrane-spanning 4-domains, subfamily A, member 6D
chr5_+_66968559 3.536 ENSMUST00000127184.1
 Limch1
LIM and calponin homology domains 1
chr7_-_45103747 3.501 ENSMUST00000003512.7
 Fcgrt
Fc receptor, IgG, alpha chain transporter
chr1_+_58210397 3.462 ENSMUST00000040442.5
 Aox4
aldehyde oxidase 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 157 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 9.7 GO:0019532 oxalate transport(GO:0019532)
0.1 9.0 GO:0007416 synapse assembly(GO:0007416)
2.1 8.3 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.0 7.0 GO:0031032 actomyosin structure organization(GO:0031032)
0.5 6.7 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 5.8 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.5 5.3 GO:0015824 proline transport(GO:0015824)
1.6 4.9 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.3 4.6 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.1 4.5 GO:1902593 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744) single-organism nuclear import(GO:1902593)
0.1 4.5 GO:0030032 lamellipodium assembly(GO:0030032)
1.0 4.2 GO:0032788 saturated monocarboxylic acid metabolic process(GO:0032788) unsaturated monocarboxylic acid metabolic process(GO:0032789)
0.5 4.2 GO:0071420 cellular response to histamine(GO:0071420)
1.0 4.1 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.2 3.8 GO:0042541 hemoglobin biosynthetic process(GO:0042541)
1.2 3.5 GO:0046110 xanthine metabolic process(GO:0046110)
0.8 3.3 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.4 3.3 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.4 3.3 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.5 3.2 GO:0060267 positive regulation of respiratory burst(GO:0060267)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 18.5 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 9.2 GO:0031226 intrinsic component of plasma membrane(GO:0031226)
0.1 7.4 GO:0031594 neuromuscular junction(GO:0031594)
0.3 6.7 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 6.0 GO:0000139 Golgi membrane(GO:0000139)
0.3 5.1 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.3 4.3 GO:0042581 specific granule(GO:0042581)
0.3 4.2 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 4.0 GO:0031225 anchored component of membrane(GO:0031225)
0.1 3.8 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 3.6 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 3.6 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 3.4 GO:0009986 cell surface(GO:0009986)
0.7 3.3 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
0.4 3.3 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.3 3.3 GO:0000138 Golgi trans cisterna(GO:0000138)
0.1 3.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 3.2 GO:0031672 A band(GO:0031672)
0.1 3.1 GO:0035371 microtubule plus-end(GO:0035371)
0.0 2.9 GO:0016324 apical plasma membrane(GO:0016324)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 126 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 9.7 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
1.1 6.6 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 6.6 GO:0030165 PDZ domain binding(GO:0030165)
0.4 6.3 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.2 5.9 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.7 5.3 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.0 5.2 GO:0017137 Rab GTPase binding(GO:0017137)
1.6 4.9 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.1 4.9 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 4.9 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 4.6 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.7 4.2 GO:1904315 GABA-gated chloride ion channel activity(GO:0022851) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.2 3.9 GO:0042287 MHC protein binding(GO:0042287)
0.9 3.5 GO:0030151 molybdenum ion binding(GO:0030151)
0.7 3.5 GO:0019770 IgG receptor activity(GO:0019770)
0.0 3.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.7 3.3 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.6 3.3 GO:0070699 type II activin receptor binding(GO:0070699)
1.1 3.2 GO:0016748 succinyltransferase activity(GO:0016748)
0.1 3.2 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.9 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.1 3.3 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.2 2.8 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 2.8 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.8 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 1.7 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 1.4 PID_MET_PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 1.3 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 1.2 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.2 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 1.2 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.0 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 1.0 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 1.0 PID_CXCR4_PATHWAY CXCR4-mediated signaling events
0.0 1.0 PID_MTOR_4PATHWAY mTOR signaling pathway
0.1 0.9 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway
0.0 0.8 PID_EPO_PATHWAY EPO signaling pathway
0.0 0.8 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.6 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.0 0.5 PID_HNF3A_PATHWAY FOXA1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 15.0 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 6.7 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.3 5.7 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.2 5.2 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.1 4.3 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.3 4.2 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.2 4.2 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 3.7 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.3 3.3 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 3.3 REACTOME_ACTIVATION_OF_KAINATE_RECEPTORS_UPON_GLUTAMATE_BINDING Genes involved in Activation of Kainate Receptors upon glutamate binding
0.0 3.1 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 2.8 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 2.7 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.1 2.5 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.2 2.4 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.2 2.2 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.2 2.2 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.3 2.1 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 1.8 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 1.8 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling