Motif ID: Dlx5_Dlx4
Z-value: 1.215
Transcription factors associated with Dlx5_Dlx4:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Dlx4 | ENSMUSG00000020871.7 | Dlx4 |
| Dlx5 | ENSMUSG00000029755.9 | Dlx5 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Dlx5 | mm10_v2_chr6_-_6882068_6882092 | -0.32 | 1.7e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 17.4 | GO:0035726 | common myeloid progenitor cell proliferation(GO:0035726) |
| 1.2 | 3.6 | GO:0060598 | dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598) |
| 1.1 | 3.2 | GO:0003221 | right ventricular cardiac muscle tissue morphogenesis(GO:0003221) |
| 1.0 | 4.2 | GO:0010808 | positive regulation of synaptic vesicle priming(GO:0010808) |
| 1.0 | 3.1 | GO:0002669 | positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913) |
| 0.9 | 2.6 | GO:0060489 | orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490) |
| 0.7 | 2.0 | GO:0060023 | soft palate development(GO:0060023) |
| 0.7 | 2.6 | GO:0035609 | C-terminal protein deglutamylation(GO:0035609) |
| 0.7 | 2.0 | GO:0072139 | glomerular parietal epithelial cell differentiation(GO:0072139) |
| 0.6 | 1.8 | GO:1904884 | telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884) |
| 0.6 | 3.0 | GO:0051661 | maintenance of centrosome location(GO:0051661) |
| 0.6 | 1.8 | GO:0060729 | intestinal epithelial structure maintenance(GO:0060729) |
| 0.6 | 2.2 | GO:0006742 | NADP catabolic process(GO:0006742) pyridine nucleotide catabolic process(GO:0019364) |
| 0.5 | 2.2 | GO:0060316 | positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316) |
| 0.5 | 9.8 | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore(GO:0051988) |
| 0.5 | 2.7 | GO:1904659 | glucose transmembrane transport(GO:1904659) |
| 0.5 | 3.7 | GO:0006975 | DNA damage induced protein phosphorylation(GO:0006975) |
| 0.5 | 1.6 | GO:1902498 | regulation of protein autoubiquitination(GO:1902498) |
| 0.5 | 1.9 | GO:0036091 | positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091) |
| 0.5 | 1.5 | GO:0061300 | cerebellum vasculature development(GO:0061300) |
| 0.5 | 1.4 | GO:0006592 | ornithine biosynthetic process(GO:0006592) |
| 0.5 | 7.9 | GO:0033234 | negative regulation of protein sumoylation(GO:0033234) |
| 0.5 | 0.5 | GO:0097694 | establishment of RNA localization to telomere(GO:0097694) |
| 0.5 | 5.5 | GO:2001269 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269) |
| 0.5 | 1.4 | GO:1900039 | positive regulation of cellular response to hypoxia(GO:1900039) |
| 0.5 | 4.5 | GO:0033314 | mitotic DNA replication checkpoint(GO:0033314) |
| 0.4 | 3.1 | GO:0030035 | microspike assembly(GO:0030035) |
| 0.4 | 1.2 | GO:0035359 | negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359) |
| 0.4 | 1.5 | GO:0071596 | ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596) |
| 0.4 | 3.0 | GO:0016576 | histone dephosphorylation(GO:0016576) |
| 0.4 | 1.1 | GO:0038165 | oncostatin-M-mediated signaling pathway(GO:0038165) |
| 0.4 | 1.1 | GO:0070649 | meiotic chromosome movement towards spindle pole(GO:0016344) formin-nucleated actin cable assembly(GO:0070649) |
| 0.4 | 1.4 | GO:0015744 | succinate transport(GO:0015744) |
| 0.4 | 0.7 | GO:0090365 | regulation of mRNA modification(GO:0090365) |
| 0.4 | 1.1 | GO:0014022 | neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007) |
| 0.3 | 4.9 | GO:0072431 | signal transduction involved in mitotic G1 DNA damage checkpoint(GO:0072431) intracellular signal transduction involved in G1 DNA damage checkpoint(GO:1902400) |
| 0.3 | 1.0 | GO:0021577 | hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589) |
| 0.3 | 3.1 | GO:0098700 | neurotransmitter loading into synaptic vesicle(GO:0098700) |
| 0.3 | 0.9 | GO:0038044 | negative regulation of receptor biosynthetic process(GO:0010871) transforming growth factor-beta secretion(GO:0038044) |
| 0.3 | 4.6 | GO:2000042 | negative regulation of double-strand break repair via homologous recombination(GO:2000042) |
| 0.3 | 0.9 | GO:0018103 | protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406) |
| 0.3 | 1.8 | GO:0048840 | otolith development(GO:0048840) |
| 0.3 | 1.2 | GO:0042905 | 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
| 0.3 | 0.8 | GO:1904760 | myofibroblast differentiation(GO:0036446) regulation of myofibroblast differentiation(GO:1904760) |
| 0.3 | 0.6 | GO:0010920 | negative regulation of inositol phosphate biosynthetic process(GO:0010920) |
| 0.3 | 1.1 | GO:0046619 | optic placode formation involved in camera-type eye formation(GO:0046619) |
| 0.3 | 2.9 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 0.3 | 2.1 | GO:0071802 | negative regulation of podosome assembly(GO:0071802) |
| 0.3 | 1.0 | GO:0070829 | heterochromatin maintenance(GO:0070829) |
| 0.3 | 1.3 | GO:2001168 | regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168) |
| 0.2 | 1.0 | GO:1900377 | negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377) |
| 0.2 | 1.0 | GO:0015825 | L-serine transport(GO:0015825) |
| 0.2 | 0.7 | GO:0060743 | epithelial cell maturation involved in prostate gland development(GO:0060743) |
| 0.2 | 2.6 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
| 0.2 | 1.2 | GO:1903232 | melanosome assembly(GO:1903232) |
| 0.2 | 0.7 | GO:0019046 | release from viral latency(GO:0019046) regulation of DNA strand elongation(GO:0060382) |
| 0.2 | 10.1 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.2 | 0.9 | GO:0031580 | membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580) |
| 0.2 | 0.9 | GO:0060800 | regulation of cell differentiation involved in embryonic placenta development(GO:0060800) |
| 0.2 | 1.5 | GO:0097151 | positive regulation of inhibitory postsynaptic potential(GO:0097151) |
| 0.2 | 1.7 | GO:0071372 | cellular response to follicle-stimulating hormone stimulus(GO:0071372) |
| 0.2 | 1.0 | GO:0090310 | negative regulation of methylation-dependent chromatin silencing(GO:0090310) |
| 0.2 | 1.0 | GO:0006570 | tyrosine metabolic process(GO:0006570) |
| 0.2 | 3.0 | GO:0021796 | cerebral cortex regionalization(GO:0021796) |
| 0.2 | 5.3 | GO:0010842 | retina layer formation(GO:0010842) |
| 0.2 | 0.8 | GO:0006933 | negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933) |
| 0.2 | 2.6 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.2 | 1.3 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.2 | 0.9 | GO:0070562 | regulation of vitamin D receptor signaling pathway(GO:0070562) |
| 0.2 | 0.7 | GO:0033762 | response to glucagon(GO:0033762) |
| 0.2 | 1.0 | GO:0009235 | cobalamin metabolic process(GO:0009235) |
| 0.2 | 0.8 | GO:0018158 | protein oxidation(GO:0018158) |
| 0.2 | 0.5 | GO:0071963 | establishment or maintenance of cell polarity regulating cell shape(GO:0071963) |
| 0.2 | 0.7 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.2 | 0.5 | GO:0097278 | transforming growth factor beta activation(GO:0036363) complement-dependent cytotoxicity(GO:0097278) |
| 0.2 | 1.6 | GO:0051574 | positive regulation of histone H3-K9 methylation(GO:0051574) |
| 0.2 | 2.7 | GO:0001833 | inner cell mass cell proliferation(GO:0001833) |
| 0.2 | 0.5 | GO:0002035 | brain renin-angiotensin system(GO:0002035) |
| 0.2 | 6.6 | GO:0042773 | ATP synthesis coupled electron transport(GO:0042773) |
| 0.2 | 0.5 | GO:0046544 | regulation of natural killer cell proliferation(GO:0032817) positive regulation of natural killer cell proliferation(GO:0032819) development of secondary male sexual characteristics(GO:0046544) |
| 0.2 | 0.5 | GO:0035521 | monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522) |
| 0.2 | 0.8 | GO:0035720 | intraciliary anterograde transport(GO:0035720) |
| 0.2 | 0.8 | GO:0036324 | negative regulation of toll-like receptor 4 signaling pathway(GO:0034144) vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324) |
| 0.1 | 0.3 | GO:0070827 | chromatin maintenance(GO:0070827) |
| 0.1 | 2.9 | GO:0007530 | sex determination(GO:0007530) |
| 0.1 | 0.3 | GO:0021506 | anterior neuropore closure(GO:0021506) neuropore closure(GO:0021995) |
| 0.1 | 8.4 | GO:0008347 | glial cell migration(GO:0008347) |
| 0.1 | 0.9 | GO:0006307 | DNA dealkylation involved in DNA repair(GO:0006307) |
| 0.1 | 0.4 | GO:0006404 | RNA import into nucleus(GO:0006404) snRNA transport(GO:0051030) |
| 0.1 | 0.7 | GO:0046208 | spermine catabolic process(GO:0046208) |
| 0.1 | 4.1 | GO:0034723 | DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723) |
| 0.1 | 0.3 | GO:1902174 | positive regulation of keratinocyte apoptotic process(GO:1902174) |
| 0.1 | 0.5 | GO:0030647 | polyketide metabolic process(GO:0030638) aminoglycoside antibiotic metabolic process(GO:0030647) daunorubicin metabolic process(GO:0044597) doxorubicin metabolic process(GO:0044598) |
| 0.1 | 0.4 | GO:0098501 | polynucleotide dephosphorylation(GO:0098501) |
| 0.1 | 1.0 | GO:2000491 | positive regulation of hepatic stellate cell activation(GO:2000491) |
| 0.1 | 0.4 | GO:1901675 | response to methylglyoxal(GO:0051595) negative regulation of histone H3-K27 acetylation(GO:1901675) |
| 0.1 | 0.8 | GO:0000414 | regulation of histone H3-K36 methylation(GO:0000414) |
| 0.1 | 0.4 | GO:0048245 | eosinophil chemotaxis(GO:0048245) |
| 0.1 | 0.4 | GO:0032289 | central nervous system myelin formation(GO:0032289) cardiac cell fate specification(GO:0060912) |
| 0.1 | 0.5 | GO:0015692 | vanadium ion transport(GO:0015676) lead ion transport(GO:0015692) |
| 0.1 | 0.7 | GO:0010758 | regulation of macrophage chemotaxis(GO:0010758) |
| 0.1 | 0.3 | GO:0070933 | histone H4 deacetylation(GO:0070933) |
| 0.1 | 3.8 | GO:0000578 | embryonic axis specification(GO:0000578) |
| 0.1 | 2.7 | GO:0051560 | mitochondrial calcium ion homeostasis(GO:0051560) |
| 0.1 | 4.4 | GO:0042491 | auditory receptor cell differentiation(GO:0042491) |
| 0.1 | 1.1 | GO:0001675 | acrosome assembly(GO:0001675) |
| 0.1 | 0.9 | GO:0090527 | actin filament reorganization(GO:0090527) |
| 0.1 | 7.0 | GO:0008543 | fibroblast growth factor receptor signaling pathway(GO:0008543) |
| 0.1 | 0.7 | GO:0048386 | positive regulation of retinoic acid receptor signaling pathway(GO:0048386) |
| 0.1 | 0.4 | GO:0043654 | recognition of apoptotic cell(GO:0043654) |
| 0.1 | 1.4 | GO:0060065 | uterus development(GO:0060065) |
| 0.1 | 1.3 | GO:0051451 | myoblast migration(GO:0051451) |
| 0.1 | 0.3 | GO:0070650 | actin filament bundle distribution(GO:0070650) |
| 0.1 | 0.6 | GO:0098885 | modification of postsynaptic actin cytoskeleton(GO:0098885) |
| 0.1 | 0.7 | GO:0071539 | protein localization to centrosome(GO:0071539) |
| 0.1 | 3.1 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 0.1 | 0.3 | GO:0090309 | positive regulation of methylation-dependent chromatin silencing(GO:0090309) |
| 0.1 | 0.3 | GO:0045006 | DNA deamination(GO:0045006) |
| 0.1 | 0.2 | GO:0032914 | positive regulation of transforming growth factor beta1 production(GO:0032914) |
| 0.1 | 0.6 | GO:0006620 | posttranslational protein targeting to membrane(GO:0006620) |
| 0.1 | 2.5 | GO:0034508 | centromere complex assembly(GO:0034508) |
| 0.1 | 1.4 | GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539) |
| 0.1 | 0.2 | GO:0006776 | vitamin A metabolic process(GO:0006776) |
| 0.1 | 1.1 | GO:0003334 | keratinocyte development(GO:0003334) |
| 0.1 | 5.3 | GO:0051489 | regulation of filopodium assembly(GO:0051489) |
| 0.1 | 0.6 | GO:1900194 | negative regulation of oocyte development(GO:0060283) negative regulation of oocyte maturation(GO:1900194) |
| 0.1 | 0.7 | GO:0009404 | toxin metabolic process(GO:0009404) |
| 0.1 | 1.6 | GO:0048026 | positive regulation of mRNA splicing, via spliceosome(GO:0048026) |
| 0.1 | 0.8 | GO:1903504 | regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504) |
| 0.1 | 1.7 | GO:0072337 | modified amino acid transport(GO:0072337) |
| 0.1 | 0.8 | GO:0050860 | negative regulation of T cell receptor signaling pathway(GO:0050860) |
| 0.1 | 0.2 | GO:2001012 | mesenchymal cell differentiation involved in kidney development(GO:0072161) mesenchymal cell differentiation involved in renal system development(GO:2001012) |
| 0.1 | 0.5 | GO:0006265 | DNA topological change(GO:0006265) |
| 0.1 | 2.9 | GO:0006493 | protein O-linked glycosylation(GO:0006493) |
| 0.1 | 0.6 | GO:0002523 | leukocyte migration involved in inflammatory response(GO:0002523) |
| 0.1 | 0.2 | GO:0070857 | regulation of bile acid biosynthetic process(GO:0070857) positive regulation of bile acid biosynthetic process(GO:0070859) positive regulation of bile acid metabolic process(GO:1904253) |
| 0.1 | 0.6 | GO:0009301 | snRNA transcription(GO:0009301) |
| 0.1 | 0.8 | GO:0007250 | activation of NF-kappaB-inducing kinase activity(GO:0007250) |
| 0.1 | 0.2 | GO:0002188 | translation reinitiation(GO:0002188) |
| 0.1 | 0.4 | GO:0046477 | glycosylceramide catabolic process(GO:0046477) |
| 0.1 | 0.4 | GO:0070092 | regulation of glucagon secretion(GO:0070092) |
| 0.1 | 0.3 | GO:0045919 | positive regulation of cytolysis(GO:0045919) |
| 0.1 | 0.7 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
| 0.1 | 0.3 | GO:0014886 | transition between slow and fast fiber(GO:0014886) |
| 0.1 | 0.8 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 0.1 | 0.6 | GO:0080009 | mRNA methylation(GO:0080009) |
| 0.1 | 0.2 | GO:0019085 | early viral transcription(GO:0019085) |
| 0.1 | 2.1 | GO:0050982 | detection of mechanical stimulus(GO:0050982) |
| 0.1 | 0.7 | GO:0006107 | oxaloacetate metabolic process(GO:0006107) |
| 0.1 | 1.3 | GO:0003016 | respiratory system process(GO:0003016) |
| 0.1 | 0.7 | GO:0090435 | protein localization to nuclear envelope(GO:0090435) |
| 0.0 | 0.5 | GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886) |
| 0.0 | 1.2 | GO:0006471 | protein ADP-ribosylation(GO:0006471) |
| 0.0 | 0.4 | GO:0090160 | Golgi to lysosome transport(GO:0090160) |
| 0.0 | 1.6 | GO:0071385 | cellular response to glucocorticoid stimulus(GO:0071385) |
| 0.0 | 6.6 | GO:0006338 | chromatin remodeling(GO:0006338) |
| 0.0 | 0.4 | GO:0009162 | deoxyribonucleoside monophosphate metabolic process(GO:0009162) |
| 0.0 | 1.4 | GO:0060325 | face morphogenesis(GO:0060325) |
| 0.0 | 0.1 | GO:1903630 | regulation of aminoacyl-tRNA ligase activity(GO:1903630) positive regulation of aminoacyl-tRNA ligase activity(GO:1903632) regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435) |
| 0.0 | 0.3 | GO:0060712 | spongiotrophoblast layer development(GO:0060712) |
| 0.0 | 0.4 | GO:0007216 | G-protein coupled glutamate receptor signaling pathway(GO:0007216) |
| 0.0 | 0.4 | GO:1990440 | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440) |
| 0.0 | 4.6 | GO:0002028 | regulation of sodium ion transport(GO:0002028) |
| 0.0 | 0.3 | GO:0060347 | heart trabecula formation(GO:0060347) |
| 0.0 | 0.6 | GO:0008090 | retrograde axonal transport(GO:0008090) |
| 0.0 | 0.2 | GO:1902268 | negative regulation of polyamine transmembrane transport(GO:1902268) |
| 0.0 | 1.4 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.0 | 0.3 | GO:0046827 | positive regulation of protein export from nucleus(GO:0046827) |
| 0.0 | 0.2 | GO:0043922 | negative regulation by host of viral transcription(GO:0043922) |
| 0.0 | 1.6 | GO:0031648 | protein destabilization(GO:0031648) |
| 0.0 | 0.5 | GO:0019730 | antimicrobial humoral response(GO:0019730) |
| 0.0 | 1.4 | GO:0051693 | actin filament capping(GO:0051693) |
| 0.0 | 1.1 | GO:0045104 | intermediate filament cytoskeleton organization(GO:0045104) |
| 0.0 | 1.2 | GO:0030520 | intracellular estrogen receptor signaling pathway(GO:0030520) |
| 0.0 | 0.6 | GO:0035855 | megakaryocyte development(GO:0035855) |
| 0.0 | 0.5 | GO:0048280 | vesicle fusion with Golgi apparatus(GO:0048280) |
| 0.0 | 0.3 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 0.0 | 1.5 | GO:0008156 | negative regulation of DNA replication(GO:0008156) |
| 0.0 | 1.3 | GO:0000462 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462) |
| 0.0 | 0.1 | GO:0060126 | somatotropin secreting cell differentiation(GO:0060126) |
| 0.0 | 0.1 | GO:0009814 | defense response, incompatible interaction(GO:0009814) |
| 0.0 | 0.3 | GO:0060746 | parental behavior(GO:0060746) |
| 0.0 | 0.6 | GO:0090201 | negative regulation of release of cytochrome c from mitochondria(GO:0090201) |
| 0.0 | 1.5 | GO:0006635 | fatty acid beta-oxidation(GO:0006635) |
| 0.0 | 0.4 | GO:0010457 | centriole-centriole cohesion(GO:0010457) |
| 0.0 | 1.5 | GO:0006940 | regulation of smooth muscle contraction(GO:0006940) |
| 0.0 | 0.8 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 0.0 | 1.8 | GO:0051865 | protein autoubiquitination(GO:0051865) |
| 0.0 | 0.2 | GO:0002192 | IRES-dependent translational initiation(GO:0002192) IRES-dependent viral translational initiation(GO:0075522) |
| 0.0 | 1.4 | GO:0007606 | sensory perception of chemical stimulus(GO:0007606) |
| 0.0 | 0.2 | GO:0045721 | negative regulation of gluconeogenesis(GO:0045721) |
| 0.0 | 0.2 | GO:0051790 | short-chain fatty acid biosynthetic process(GO:0051790) |
| 0.0 | 0.6 | GO:0006099 | tricarboxylic acid cycle(GO:0006099) |
| 0.0 | 0.6 | GO:0032467 | positive regulation of cytokinesis(GO:0032467) |
| 0.0 | 0.6 | GO:0051497 | negative regulation of stress fiber assembly(GO:0051497) |
| 0.0 | 0.3 | GO:0044030 | regulation of DNA methylation(GO:0044030) |
| 0.0 | 0.5 | GO:0006907 | pinocytosis(GO:0006907) |
| 0.0 | 0.1 | GO:2001271 | negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271) |
| 0.0 | 0.1 | GO:1904321 | response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322) |
| 0.0 | 0.8 | GO:0043407 | negative regulation of MAP kinase activity(GO:0043407) |
| 0.0 | 0.1 | GO:0007202 | activation of phospholipase C activity(GO:0007202) |
| 0.0 | 0.3 | GO:0031571 | mitotic G1 DNA damage checkpoint(GO:0031571) |
| 0.0 | 0.1 | GO:0036003 | positive regulation of transcription from RNA polymerase II promoter in response to stress(GO:0036003) |
| 0.0 | 0.2 | GO:0090557 | establishment of endothelial intestinal barrier(GO:0090557) |
| 0.0 | 0.4 | GO:0071577 | zinc II ion transmembrane transport(GO:0071577) |
| 0.0 | 0.2 | GO:0009048 | dosage compensation by inactivation of X chromosome(GO:0009048) |
| 0.0 | 0.9 | GO:0007019 | microtubule depolymerization(GO:0007019) |
| 0.0 | 0.4 | GO:0010667 | negative regulation of cardiac muscle cell apoptotic process(GO:0010667) |
| 0.0 | 0.0 | GO:0000389 | generation of catalytic spliceosome for second transesterification step(GO:0000350) mRNA 3'-splice site recognition(GO:0000389) |
| 0.0 | 0.5 | GO:0007219 | Notch signaling pathway(GO:0007219) |
| 0.0 | 0.9 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.0 | 0.3 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.0 | 0.2 | GO:0045722 | positive regulation of gluconeogenesis(GO:0045722) |
| 0.0 | 1.1 | GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154) |
| 0.0 | 0.2 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.0 | 0.5 | GO:0030514 | negative regulation of BMP signaling pathway(GO:0030514) |
| 0.0 | 0.5 | GO:0032011 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
| 0.0 | 0.2 | GO:0048266 | behavioral response to pain(GO:0048266) |
| 0.0 | 0.4 | GO:0051568 | histone H3-K4 methylation(GO:0051568) |
| 0.0 | 0.2 | GO:0007613 | memory(GO:0007613) |
| 0.0 | 1.4 | GO:1900006 | positive regulation of dendrite development(GO:1900006) |
| 0.0 | 0.3 | GO:0010564 | regulation of cell cycle process(GO:0010564) |
| 0.0 | 0.1 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
| 0.0 | 0.4 | GO:0031110 | regulation of microtubule polymerization or depolymerization(GO:0031110) |
| 0.0 | 0.2 | GO:0006490 | oligosaccharide-lipid intermediate biosynthetic process(GO:0006490) |
| 0.0 | 0.4 | GO:0051321 | meiotic cell cycle(GO:0051321) |
| 0.0 | 0.2 | GO:0035414 | negative regulation of catenin import into nucleus(GO:0035414) |
| 0.0 | 0.2 | GO:0010771 | negative regulation of cell morphogenesis involved in differentiation(GO:0010771) |
| 0.0 | 0.7 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 0.0 | 0.3 | GO:2000785 | regulation of autophagosome assembly(GO:2000785) |
| 0.0 | 1.5 | GO:0007519 | skeletal muscle tissue development(GO:0007519) |
| 0.0 | 0.4 | GO:0007029 | endoplasmic reticulum organization(GO:0007029) |
| 0.0 | 1.2 | GO:0019827 | stem cell population maintenance(GO:0019827) maintenance of cell number(GO:0098727) |
| 0.0 | 2.2 | GO:0007059 | chromosome segregation(GO:0007059) |
| 0.0 | 0.2 | GO:0050853 | complement activation, classical pathway(GO:0006958) B cell receptor signaling pathway(GO:0050853) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 7.9 | GO:0002111 | BRCA2-BRAF35 complex(GO:0002111) |
| 1.6 | 6.5 | GO:0008623 | CHRAC(GO:0008623) |
| 1.2 | 3.7 | GO:0070557 | PCNA-p21 complex(GO:0070557) |
| 0.7 | 4.2 | GO:0044305 | calyx of Held(GO:0044305) |
| 0.7 | 2.6 | GO:0060187 | cell pole(GO:0060187) |
| 0.7 | 2.0 | GO:0071914 | prominosome(GO:0071914) |
| 0.6 | 3.2 | GO:0036449 | microtubule minus-end(GO:0036449) |
| 0.4 | 2.1 | GO:0031262 | Ndc80 complex(GO:0031262) |
| 0.3 | 1.7 | GO:0031466 | Cul5-RING ubiquitin ligase complex(GO:0031466) |
| 0.3 | 1.3 | GO:0031983 | vesicle lumen(GO:0031983) |
| 0.3 | 0.9 | GO:0034684 | integrin alphav-beta5 complex(GO:0034684) |
| 0.3 | 9.3 | GO:1990752 | microtubule plus-end(GO:0035371) microtubule end(GO:1990752) |
| 0.2 | 2.1 | GO:0030478 | actin cap(GO:0030478) |
| 0.2 | 1.7 | GO:0060053 | neurofilament cytoskeleton(GO:0060053) |
| 0.2 | 1.2 | GO:0005958 | DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) |
| 0.2 | 1.0 | GO:0030485 | smooth muscle contractile fiber(GO:0030485) |
| 0.2 | 0.8 | GO:1990032 | parallel fiber(GO:1990032) |
| 0.2 | 1.3 | GO:0033503 | HULC complex(GO:0033503) |
| 0.2 | 1.4 | GO:0042382 | paraspeckles(GO:0042382) |
| 0.2 | 1.4 | GO:1990316 | ATG1/ULK1 kinase complex(GO:1990316) |
| 0.2 | 0.9 | GO:0005726 | perichromatin fibrils(GO:0005726) |
| 0.1 | 12.4 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.1 | 1.9 | GO:0032797 | SMN complex(GO:0032797) |
| 0.1 | 0.7 | GO:0070876 | SOSS complex(GO:0070876) |
| 0.1 | 2.1 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.1 | 0.4 | GO:0034657 | GID complex(GO:0034657) |
| 0.1 | 3.1 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.1 | 4.6 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.1 | 4.1 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.1 | 0.7 | GO:0000444 | MIS12/MIND type complex(GO:0000444) |
| 0.1 | 0.5 | GO:0070826 | paraferritin complex(GO:0070826) |
| 0.1 | 6.2 | GO:0016459 | myosin complex(GO:0016459) |
| 0.1 | 0.8 | GO:0097413 | Lewy body(GO:0097413) |
| 0.1 | 2.5 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
| 0.1 | 0.5 | GO:0034751 | aryl hydrocarbon receptor complex(GO:0034751) |
| 0.1 | 0.8 | GO:0001520 | outer dense fiber(GO:0001520) |
| 0.1 | 0.8 | GO:0045261 | mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261) |
| 0.1 | 0.5 | GO:0030891 | VCB complex(GO:0030891) |
| 0.1 | 1.8 | GO:0001741 | XY body(GO:0001741) |
| 0.1 | 0.8 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.1 | 0.3 | GO:0031467 | Cul7-RING ubiquitin ligase complex(GO:0031467) |
| 0.1 | 1.5 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 0.1 | 0.5 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.1 | 0.5 | GO:0097422 | tubular endosome(GO:0097422) |
| 0.1 | 5.2 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.1 | 0.3 | GO:0002189 | ribose phosphate diphosphokinase complex(GO:0002189) |
| 0.1 | 1.2 | GO:0030008 | TRAPP complex(GO:0030008) |
| 0.1 | 1.6 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.1 | 0.5 | GO:0070187 | telosome(GO:0070187) |
| 0.1 | 1.0 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 0.1 | 6.9 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.1 | 0.8 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.1 | 0.6 | GO:0045252 | oxoglutarate dehydrogenase complex(GO:0045252) |
| 0.1 | 0.8 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.1 | 0.3 | GO:1990130 | Iml1 complex(GO:1990130) |
| 0.1 | 3.6 | GO:0005657 | replication fork(GO:0005657) |
| 0.1 | 0.8 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.1 | 1.1 | GO:0033276 | transcription factor TFTC complex(GO:0033276) |
| 0.1 | 0.2 | GO:0071008 | U2-type post-mRNA release spliceosomal complex(GO:0071008) |
| 0.1 | 1.0 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.0 | 2.1 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 0.6 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.0 | 0.5 | GO:0000177 | cytoplasmic exosome (RNase complex)(GO:0000177) |
| 0.0 | 4.5 | GO:0005814 | centriole(GO:0005814) |
| 0.0 | 0.7 | GO:0045120 | pronucleus(GO:0045120) |
| 0.0 | 2.9 | GO:0000792 | heterochromatin(GO:0000792) |
| 0.0 | 0.2 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
| 0.0 | 7.2 | GO:0000775 | chromosome, centromeric region(GO:0000775) |
| 0.0 | 0.4 | GO:0000243 | commitment complex(GO:0000243) |
| 0.0 | 0.4 | GO:0044666 | MLL3/4 complex(GO:0044666) |
| 0.0 | 0.4 | GO:0051286 | cell tip(GO:0051286) |
| 0.0 | 0.7 | GO:0005682 | U5 snRNP(GO:0005682) |
| 0.0 | 0.4 | GO:0031045 | dense core granule(GO:0031045) |
| 0.0 | 0.7 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.0 | 0.1 | GO:0005594 | collagen type IX trimer(GO:0005594) |
| 0.0 | 0.8 | GO:0098839 | postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634) |
| 0.0 | 0.3 | GO:1990391 | DNA repair complex(GO:1990391) |
| 0.0 | 0.8 | GO:0031519 | PcG protein complex(GO:0031519) |
| 0.0 | 0.2 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.0 | 0.4 | GO:0033655 | host cell cytoplasm(GO:0030430) host cell cytoplasm part(GO:0033655) |
| 0.0 | 2.4 | GO:0030175 | filopodium(GO:0030175) |
| 0.0 | 0.3 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.0 | 0.1 | GO:0090568 | nuclear transcriptional repressor complex(GO:0090568) RNA polymerase II transcription repressor complex(GO:0090571) |
| 0.0 | 0.9 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.0 | 0.7 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.0 | 0.9 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 1.2 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 1.4 | GO:0005844 | polysome(GO:0005844) |
| 0.0 | 0.6 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 1.1 | GO:0005938 | cell cortex(GO:0005938) |
| 0.0 | 0.2 | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541) |
| 0.0 | 1.8 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.0 | 0.1 | GO:0002177 | manchette(GO:0002177) |
| 0.0 | 0.3 | GO:0030061 | mitochondrial crista(GO:0030061) |
| 0.0 | 0.1 | GO:0001674 | female germ cell nucleus(GO:0001674) |
| 0.0 | 1.1 | GO:0005902 | microvillus(GO:0005902) |
| 0.0 | 1.1 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.0 | 0.3 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.0 | 0.4 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.0 | 7.9 | GO:0005694 | chromosome(GO:0005694) |
| 0.0 | 0.9 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.0 | 0.2 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.0 | 0.6 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 0.4 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.0 | 0.2 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
| 0.0 | 1.5 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 0.4 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.0 | 0.1 | GO:0030134 | ER to Golgi transport vesicle(GO:0030134) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 4.2 | GO:0001565 | phorbol ester receptor activity(GO:0001565) non-kinase phorbol ester receptor activity(GO:0001566) |
| 1.2 | 3.7 | GO:0035402 | histone kinase activity (H3-T11 specific)(GO:0035402) |
| 1.2 | 3.7 | GO:0019912 | cyclin-dependent protein kinase activating kinase activity(GO:0019912) |
| 0.9 | 3.4 | GO:0035529 | NADH pyrophosphatase activity(GO:0035529) |
| 0.8 | 4.6 | GO:0061649 | ubiquitinated histone binding(GO:0061649) |
| 0.8 | 4.5 | GO:0010997 | anaphase-promoting complex binding(GO:0010997) |
| 0.5 | 1.4 | GO:0015140 | malate transmembrane transporter activity(GO:0015140) |
| 0.5 | 1.4 | GO:0017084 | glutamate 5-kinase activity(GO:0004349) glutamate-5-semialdehyde dehydrogenase activity(GO:0004350) delta1-pyrroline-5-carboxylate synthetase activity(GO:0017084) amino acid kinase activity(GO:0019202) |
| 0.5 | 1.4 | GO:0017099 | very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099) |
| 0.5 | 1.8 | GO:0032405 | MutLalpha complex binding(GO:0032405) |
| 0.4 | 1.2 | GO:0003953 | NAD+ nucleosidase activity(GO:0003953) |
| 0.4 | 1.2 | GO:0008392 | arachidonic acid epoxygenase activity(GO:0008392) |
| 0.4 | 1.2 | GO:0004677 | DNA-dependent protein kinase activity(GO:0004677) |
| 0.4 | 1.1 | GO:0004923 | leukemia inhibitory factor receptor activity(GO:0004923) oncostatin-M receptor activity(GO:0004924) |
| 0.4 | 6.6 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.3 | 10.0 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.3 | 7.6 | GO:0000400 | four-way junction DNA binding(GO:0000400) |
| 0.3 | 1.5 | GO:0004165 | dodecenoyl-CoA delta-isomerase activity(GO:0004165) |
| 0.3 | 1.2 | GO:0015220 | choline transmembrane transporter activity(GO:0015220) |
| 0.2 | 1.4 | GO:0070728 | leucine binding(GO:0070728) |
| 0.2 | 0.7 | GO:0016715 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715) |
| 0.2 | 0.7 | GO:0046592 | polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901) |
| 0.2 | 3.9 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.2 | 1.7 | GO:0005004 | GPI-linked ephrin receptor activity(GO:0005004) |
| 0.2 | 1.0 | GO:0008172 | S-methyltransferase activity(GO:0008172) |
| 0.2 | 1.0 | GO:0008273 | calcium, potassium:sodium antiporter activity(GO:0008273) |
| 0.2 | 1.2 | GO:0001758 | retinal dehydrogenase activity(GO:0001758) |
| 0.2 | 0.9 | GO:0038132 | neuregulin binding(GO:0038132) |
| 0.2 | 2.7 | GO:0005355 | glucose transmembrane transporter activity(GO:0005355) |
| 0.2 | 0.7 | GO:0070330 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712) aromatase activity(GO:0070330) |
| 0.2 | 1.0 | GO:0070579 | methylcytosine dioxygenase activity(GO:0070579) |
| 0.2 | 1.4 | GO:1990405 | protein antigen binding(GO:1990405) |
| 0.2 | 7.7 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.2 | 1.4 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 0.2 | 0.5 | GO:0004711 | ribosomal protein S6 kinase activity(GO:0004711) |
| 0.2 | 0.8 | GO:0043532 | angiostatin binding(GO:0043532) |
| 0.1 | 0.4 | GO:0000386 | second spliceosomal transesterification activity(GO:0000386) |
| 0.1 | 1.0 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
| 0.1 | 1.0 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.1 | 2.0 | GO:0002161 | aminoacyl-tRNA editing activity(GO:0002161) |
| 0.1 | 0.8 | GO:0003910 | DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910) |
| 0.1 | 0.9 | GO:0043140 | ATP-dependent 3'-5' DNA helicase activity(GO:0043140) |
| 0.1 | 1.0 | GO:0016863 | intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863) |
| 0.1 | 0.9 | GO:0034056 | estrogen response element binding(GO:0034056) |
| 0.1 | 4.3 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.1 | 1.4 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.1 | 0.7 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
| 0.1 | 0.9 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.1 | 0.5 | GO:0015086 | cadmium ion transmembrane transporter activity(GO:0015086) lead ion transmembrane transporter activity(GO:0015094) vanadium ion transmembrane transporter activity(GO:0015100) ferrous iron uptake transmembrane transporter activity(GO:0015639) |
| 0.1 | 0.8 | GO:0035662 | Toll-like receptor 4 binding(GO:0035662) |
| 0.1 | 1.5 | GO:0043495 | protein anchor(GO:0043495) |
| 0.1 | 0.6 | GO:0071532 | ankyrin repeat binding(GO:0071532) |
| 0.1 | 0.5 | GO:0003917 | DNA topoisomerase type I activity(GO:0003917) |
| 0.1 | 6.0 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.1 | 0.3 | GO:0000033 | alpha-1,3-mannosyltransferase activity(GO:0000033) |
| 0.1 | 0.6 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
| 0.1 | 0.4 | GO:0008802 | betaine-aldehyde dehydrogenase activity(GO:0008802) |
| 0.1 | 0.8 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 0.1 | 1.1 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.1 | 0.5 | GO:0016655 | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor(GO:0016655) |
| 0.1 | 2.7 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.1 | 3.7 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.1 | 0.7 | GO:1990446 | U1 snRNP binding(GO:1990446) |
| 0.1 | 2.9 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.1 | 0.8 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
| 0.1 | 3.8 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.1 | 0.5 | GO:0034452 | dynactin binding(GO:0034452) |
| 0.1 | 0.3 | GO:0004749 | ribose phosphate diphosphokinase activity(GO:0004749) |
| 0.1 | 0.2 | GO:0016501 | prostacyclin receptor activity(GO:0016501) |
| 0.1 | 0.5 | GO:0004591 | oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591) |
| 0.1 | 0.7 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.1 | 0.4 | GO:0004719 | protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719) |
| 0.1 | 1.0 | GO:0022889 | L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889) |
| 0.1 | 2.1 | GO:0031435 | mitogen-activated protein kinase kinase kinase binding(GO:0031435) |
| 0.1 | 1.8 | GO:0097602 | cullin family protein binding(GO:0097602) |
| 0.1 | 1.3 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.1 | 0.3 | GO:0061665 | SUMO ligase activity(GO:0061665) |
| 0.1 | 1.5 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.1 | 2.0 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.1 | 0.4 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.1 | 2.0 | GO:0042805 | actinin binding(GO:0042805) |
| 0.1 | 0.4 | GO:0098519 | nucleotide phosphatase activity, acting on free nucleotides(GO:0098519) |
| 0.1 | 0.7 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
| 0.1 | 0.3 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.1 | 3.6 | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980) |
| 0.1 | 0.9 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.1 | 0.7 | GO:0005123 | death receptor binding(GO:0005123) |
| 0.0 | 2.2 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 0.6 | GO:0008174 | mRNA methyltransferase activity(GO:0008174) |
| 0.0 | 2.0 | GO:0032452 | histone demethylase activity(GO:0032452) |
| 0.0 | 0.9 | GO:0000030 | mannosyltransferase activity(GO:0000030) |
| 0.0 | 1.0 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.0 | 1.8 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.0 | 0.3 | GO:0048101 | calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 0.0 | 1.6 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.0 | 0.3 | GO:0097027 | ubiquitin-protein transferase activator activity(GO:0097027) |
| 0.0 | 0.5 | GO:1990226 | histone methyltransferase binding(GO:1990226) |
| 0.0 | 1.9 | GO:0043621 | protein self-association(GO:0043621) |
| 0.0 | 0.9 | GO:0035613 | RNA stem-loop binding(GO:0035613) |
| 0.0 | 0.2 | GO:0004315 | 3-oxoacyl-[acyl-carrier-protein] synthase activity(GO:0004315) |
| 0.0 | 6.2 | GO:0001047 | core promoter binding(GO:0001047) |
| 0.0 | 0.4 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.0 | 0.3 | GO:0001075 | transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075) |
| 0.0 | 3.1 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 0.6 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.0 | 1.4 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.0 | 1.8 | GO:0015485 | cholesterol binding(GO:0015485) |
| 0.0 | 1.3 | GO:0031490 | chromatin DNA binding(GO:0031490) |
| 0.0 | 1.4 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
| 0.0 | 0.4 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.0 | 0.2 | GO:0071253 | connexin binding(GO:0071253) |
| 0.0 | 0.8 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 0.0 | 0.8 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 0.0 | 0.3 | GO:0048185 | activin binding(GO:0048185) |
| 0.0 | 4.0 | GO:0016779 | nucleotidyltransferase activity(GO:0016779) |
| 0.0 | 0.2 | GO:0016421 | CoA carboxylase activity(GO:0016421) |
| 0.0 | 0.1 | GO:0004839 | ubiquitin activating enzyme activity(GO:0004839) |
| 0.0 | 22.6 | GO:0043565 | sequence-specific DNA binding(GO:0043565) |
| 0.0 | 0.6 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.0 | 0.7 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.0 | 0.4 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
| 0.0 | 0.1 | GO:1990948 | ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948) |
| 0.0 | 0.4 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.0 | 1.2 | GO:0008146 | sulfotransferase activity(GO:0008146) |
| 0.0 | 0.1 | GO:0033691 | sialic acid binding(GO:0033691) |
| 0.0 | 0.2 | GO:0004128 | cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128) |
| 0.0 | 0.3 | GO:0048273 | mitogen-activated protein kinase p38 binding(GO:0048273) |
| 0.0 | 2.9 | GO:0042393 | histone binding(GO:0042393) |
| 0.0 | 0.3 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.0 | 3.2 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 1.4 | GO:0008186 | RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186) |
| 0.0 | 5.4 | GO:0061659 | ubiquitin-like protein ligase activity(GO:0061659) |
| 0.0 | 0.1 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
| 0.0 | 0.3 | GO:0045125 | bioactive lipid receptor activity(GO:0045125) |
| 0.0 | 0.1 | GO:0030292 | protein tyrosine kinase inhibitor activity(GO:0030292) |
| 0.0 | 0.7 | GO:0031369 | translation initiation factor binding(GO:0031369) |
| 0.0 | 0.3 | GO:0051219 | phosphoprotein binding(GO:0051219) |
| 0.0 | 0.3 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.0 | 0.2 | GO:0070097 | delta-catenin binding(GO:0070097) |
| 0.0 | 1.4 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.0 | 0.7 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.0 | 0.2 | GO:0005537 | mannose binding(GO:0005537) |
| 0.0 | 0.5 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.0 | 0.2 | GO:0005522 | profilin binding(GO:0005522) |
| 0.0 | 0.3 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.0 | 0.3 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 1.7 | GO:0003713 | transcription coactivator activity(GO:0003713) |
| 0.0 | 0.2 | GO:0001221 | transcription cofactor binding(GO:0001221) |
| 0.0 | 0.2 | GO:0009982 | pseudouridine synthase activity(GO:0009982) |
| 0.0 | 0.4 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 1.5 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.0 | 0.2 | GO:0016782 | transferase activity, transferring sulfur-containing groups(GO:0016782) |
| 0.0 | 0.5 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.0 | 1.0 | GO:0015078 | hydrogen ion transmembrane transporter activity(GO:0015078) |
| 0.0 | 0.1 | GO:0016427 | tRNA (cytosine) methyltransferase activity(GO:0016427) |
| 0.0 | 0.0 | GO:0071207 | histone pre-mRNA stem-loop binding(GO:0071207) |
| 0.0 | 0.6 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 7.4 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.2 | 5.9 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
| 0.1 | 5.8 | PID_ATR_PATHWAY | ATR signaling pathway |
| 0.1 | 5.9 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
| 0.1 | 3.5 | PID_WNT_NONCANONICAL_PATHWAY | Noncanonical Wnt signaling pathway |
| 0.1 | 1.5 | SA_B_CELL_RECEPTOR_COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.1 | 1.6 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
| 0.1 | 2.9 | PID_CD40_PATHWAY | CD40/CD40L signaling |
| 0.1 | 1.7 | PID_EPHA_FWDPATHWAY | EPHA forward signaling |
| 0.1 | 2.0 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 0.8 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 1.6 | PID_PDGFRA_PATHWAY | PDGFR-alpha signaling pathway |
| 0.1 | 1.1 | PID_EPHRINB_REV_PATHWAY | Ephrin B reverse signaling |
| 0.1 | 1.3 | PID_IL2_STAT5_PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.1 | 2.7 | PID_TRKR_PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.1 | 1.2 | PID_TELOMERASE_PATHWAY | Regulation of Telomerase |
| 0.0 | 3.0 | PID_RHOA_REG_PATHWAY | Regulation of RhoA activity |
| 0.0 | 1.7 | ST_G_ALPHA_I_PATHWAY | G alpha i Pathway |
| 0.0 | 1.5 | PID_BARD1_PATHWAY | BARD1 signaling events |
| 0.0 | 2.1 | PID_PLK1_PATHWAY | PLK1 signaling events |
| 0.0 | 2.0 | PID_HES_HEY_PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 0.6 | PID_EPHB_FWD_PATHWAY | EPHB forward signaling |
| 0.0 | 0.3 | PID_FCER1_PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.0 | 0.3 | PID_ALK2_PATHWAY | ALK2 signaling events |
| 0.0 | 0.5 | PID_FANCONI_PATHWAY | Fanconi anemia pathway |
| 0.0 | 0.8 | PID_LIS1_PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 1.3 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 0.5 | SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.0 | 0.8 | PID_RAS_PATHWAY | Regulation of Ras family activation |
| 0.0 | 0.7 | PID_ARF6_PATHWAY | Arf6 signaling events |
| 0.0 | 0.8 | PID_ECADHERIN_NASCENT_AJ_PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 0.3 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 0.5 | PID_VEGFR1_2_PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.0 | 1.4 | PID_HDAC_CLASSI_PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 0.3 | PID_IFNG_PATHWAY | IFN-gamma pathway |
| 0.0 | 1.2 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 0.8 | PID_P75_NTR_PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 0.9 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 0.4 | PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 0.7 | PID_PDGFRB_PATHWAY | PDGFR-beta signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 5.5 | REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.4 | 6.1 | REACTOME_CS_DS_DEGRADATION | Genes involved in CS/DS degradation |
| 0.2 | 4.7 | REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.2 | 1.5 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.2 | 2.6 | REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.1 | 3.1 | REACTOME_RNA_POL_I_PROMOTER_OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.1 | 1.5 | REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX | Genes involved in Association of licensing factors with the pre-replicative complex |
| 0.1 | 3.5 | REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.1 | 7.1 | REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.1 | 0.9 | REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 0.1 | 1.8 | REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.1 | 3.9 | REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.1 | 3.0 | REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.1 | 7.2 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 0.5 | REACTOME_PACKAGING_OF_TELOMERE_ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.1 | 3.1 | REACTOME_SMOOTH_MUSCLE_CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 2.2 | REACTOME_SULFUR_AMINO_ACID_METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.1 | 1.1 | REACTOME_PLATELET_CALCIUM_HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.1 | 0.9 | REACTOME_PECAM1_INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.1 | 1.3 | REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.1 | 0.8 | REACTOME_PURINE_CATABOLISM | Genes involved in Purine catabolism |
| 0.1 | 0.5 | REACTOME_THE_NLRP3_INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.1 | 7.8 | REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.1 | 0.7 | REACTOME_METABOLISM_OF_POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.1 | 2.0 | REACTOME_ERK_MAPK_TARGETS | Genes involved in ERK/MAPK targets |
| 0.1 | 1.0 | REACTOME_PROLONGED_ERK_ACTIVATION_EVENTS | Genes involved in Prolonged ERK activation events |
| 0.1 | 1.4 | REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.1 | 4.5 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 0.8 | REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.0 | 1.2 | REACTOME_DOUBLE_STRAND_BREAK_REPAIR | Genes involved in Double-Strand Break Repair |
| 0.0 | 1.1 | REACTOME_SIGNALING_BY_HIPPO | Genes involved in Signaling by Hippo |
| 0.0 | 0.8 | REACTOME_HS_GAG_DEGRADATION | Genes involved in HS-GAG degradation |
| 0.0 | 0.7 | REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.0 | 0.8 | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.0 | 1.5 | REACTOME_METABOLISM_OF_NON_CODING_RNA | Genes involved in Metabolism of non-coding RNA |
| 0.0 | 1.5 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 1.1 | REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.0 | 0.4 | REACTOME_MRNA_SPLICING_MINOR_PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 0.0 | 0.8 | REACTOME_GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 0.9 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 0.5 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
| 0.0 | 0.4 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 1.1 | REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.0 | 0.5 | REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.0 | 0.6 | REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter |
| 0.0 | 0.3 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.0 | 0.3 | REACTOME_ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION | Genes involved in activated TAK1 mediates p38 MAPK activation |
| 0.0 | 0.5 | REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.0 | 0.4 | REACTOME_GLYCOSPHINGOLIPID_METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.0 | 0.2 | REACTOME_STEROID_HORMONES | Genes involved in Steroid hormones |
| 0.0 | 0.3 | REACTOME_CA_DEPENDENT_EVENTS | Genes involved in Ca-dependent events |
| 0.0 | 0.3 | REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.0 | 0.2 | REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
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