Motif ID: Dmc1

Z-value: 1.114


Transcription factors associated with Dmc1:

Gene SymbolEntrez IDGene Name
Dmc1 ENSMUSG00000022429.10 Dmc1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dmc1mm10_v2_chr15_-_79605084_796051140.133.6e-01Click!


Activity profile for motif Dmc1.

activity profile for motif Dmc1


Sorted Z-values histogram for motif Dmc1

Sorted Z-values for motif Dmc1



Network of associatons between targets according to the STRING database.



First level regulatory network of Dmc1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_14229390 7.122 ENSMUST00000028045.2
 Mrc1
mannose receptor, C type 1
chr8_+_66386292 6.633 ENSMUST00000039540.5
ENSMUST00000110253.2
 March1

membrane-associated ring finger (C3HC4) 1

chr16_-_43979050 6.556 ENSMUST00000165648.1
ENSMUST00000036321.7
 Zdhhc23

zinc finger, DHHC domain containing 23

chr14_+_75955003 6.162 ENSMUST00000050120.2
 Kctd4
potassium channel tetramerisation domain containing 4
chr4_+_128058962 5.013 ENSMUST00000184063.1
 Csmd2
CUB and Sushi multiple domains 2
chr1_-_38821215 4.972 ENSMUST00000039612.4
 Lonrf2
LON peptidase N-terminal domain and ring finger 2
chr18_-_82406777 4.789 ENSMUST00000065224.6
 Galr1
galanin receptor 1
chr2_-_104257400 4.715 ENSMUST00000141159.1
 D430041D05Rik
RIKEN cDNA D430041D05 gene
chr4_+_118961578 4.678 ENSMUST00000058651.4
 Lao1
L-amino acid oxidase 1
chr1_-_173942445 4.650 ENSMUST00000042228.8
ENSMUST00000081216.5
ENSMUST00000129829.1
ENSMUST00000123708.1
ENSMUST00000111210.2
 Ifi203



Mndal
interferon activated gene 203



myeloid nuclear differentiation antigen like
chr18_+_61105561 4.607 ENSMUST00000025523.6
 Csf1r
colony stimulating factor 1 receptor
chr7_-_45103747 3.858 ENSMUST00000003512.7
 Fcgrt
Fc receptor, IgG, alpha chain transporter
chr18_+_37484955 3.722 ENSMUST00000053856.4
 Pcdhb17
protocadherin beta 17
chr10_-_70592782 3.596 ENSMUST00000162251.1
 Phyhipl
phytanoyl-CoA hydroxylase interacting protein-like
chr2_+_130405256 3.542 ENSMUST00000110281.1
ENSMUST00000028898.3
 1700020A23Rik

RIKEN cDNA 1700020A23 gene

chr1_-_79440039 3.415 ENSMUST00000049972.4
 Scg2
secretogranin II
chr18_+_23415400 3.316 ENSMUST00000115832.2
ENSMUST00000047954.7
 Dtna

dystrobrevin alpha

chr4_+_126609818 3.298 ENSMUST00000097886.3
ENSMUST00000164362.1
 5730409E04Rik

RIKEN cDNA 5730409E04Rik gene

chr5_-_104021919 3.222 ENSMUST00000031251.9
 Hsd17b11
hydroxysteroid (17-beta) dehydrogenase 11
chr6_+_86195214 3.026 ENSMUST00000032066.9
 Tgfa
transforming growth factor alpha

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 185 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 14.9 GO:0007416 synapse assembly(GO:0007416)
0.3 8.3 GO:0018345 protein palmitoylation(GO:0018345)
0.2 7.1 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.3 6.6 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
1.4 5.4 GO:0038145 macrophage colony-stimulating factor signaling pathway(GO:0038145)
1.3 5.0 GO:0006710 androgen catabolic process(GO:0006710)
1.6 4.8 GO:0051464 positive regulation of cortisol secretion(GO:0051464)
0.9 4.5 GO:0048245 eosinophil chemotaxis(GO:0048245)
0.3 4.4 GO:0033623 regulation of integrin activation(GO:0033623)
0.1 4.0 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.5 3.8 GO:0098707 ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.7 3.6 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.0 3.6 GO:0000209 protein polyubiquitination(GO:0000209)
0.3 3.4 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.2 3.0 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.2 2.9 GO:0010447 response to acidic pH(GO:0010447)
0.0 2.9 GO:0030032 lamellipodium assembly(GO:0030032)
0.9 2.7 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.2 2.7 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.2 2.6 GO:0046512 sphingosine biosynthetic process(GO:0046512) sphingoid biosynthetic process(GO:0046520)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 95 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 26.0 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 9.8 GO:0042641 actomyosin(GO:0042641)
0.0 8.3 GO:0010008 endosome membrane(GO:0010008)
0.2 7.4 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 5.5 GO:0005811 lipid particle(GO:0005811)
1.8 5.4 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.0 5.0 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 4.5 GO:0070382 exocytic vesicle(GO:0070382)
0.4 3.8 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.2 3.4 GO:0031045 dense core granule(GO:0031045)
0.2 3.4 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 3.4 GO:0031672 A band(GO:0031672)
0.2 3.3 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 2.8 GO:0005768 endosome(GO:0005768)
0.1 2.7 GO:0030673 axolemma(GO:0030673)
0.1 2.5 GO:0005637 nuclear inner membrane(GO:0005637)
0.5 2.3 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.2 2.3 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 2.2 GO:0031225 anchored component of membrane(GO:0031225)
0.2 2.1 GO:0044294 dendritic growth cone(GO:0044294)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 139 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 8.3 GO:0005537 mannose binding(GO:0005537)
0.3 8.3 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.3 6.6 GO:0042287 MHC protein binding(GO:0042287)
0.4 5.7 GO:0031005 filamin binding(GO:0031005)
0.1 5.1 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.7 5.0 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
1.2 4.8 GO:0004966 galanin receptor activity(GO:0004966)
1.6 4.7 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.9 4.5 GO:0019770 IgG receptor activity(GO:0019770)
0.0 3.9 GO:0001047 core promoter binding(GO:0001047)
0.2 3.7 GO:0005521 lamin binding(GO:0005521)
0.0 3.6 GO:0030165 PDZ domain binding(GO:0030165)
0.0 3.5 GO:0005125 cytokine activity(GO:0005125)
0.2 3.4 GO:0042056 chemoattractant activity(GO:0042056)
0.0 3.1 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0 3.1 GO:0005178 integrin binding(GO:0005178)
0.1 3.0 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 3.0 GO:0030507 spectrin binding(GO:0030507)
0.1 2.9 GO:0043236 laminin binding(GO:0043236)
0.0 2.9 GO:0061630 ubiquitin protein ligase activity(GO:0061630)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.6 PID_TCPTP_PATHWAY Signaling events mediated by TCPTP
0.1 3.6 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 3.2 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 3.0 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 2.9 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.6 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.2 2.5 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 2.3 PID_ATM_PATHWAY ATM pathway
0.0 2.1 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 2.0 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.1 1.9 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.1 1.8 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 1.7 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.1 1.7 PID_ARF6_PATHWAY Arf6 signaling events
0.0 1.7 PID_CDC42_PATHWAY CDC42 signaling events
0.0 1.3 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 1.1 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 1.0 ST_ADRENERGIC Adrenergic Pathway
0.0 0.9 PID_CXCR3_PATHWAY CXCR3-mediated signaling events
0.0 0.9 PID_CD8_TCR_PATHWAY TCR signaling in naïve CD8+ T cells

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.0 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 4.5 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.2 4.3 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.1 4.0 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
1.3 3.8 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 3.4 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 3.1 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.2 2.7 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 2.5 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 2.5 REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES Genes involved in Transmission across Chemical Synapses
0.1 2.3 REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.3 2.0 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 2.0 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 2.0 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.2 1.7 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 1.7 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 1.7 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.7 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 1.6 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 1.6 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors