Motif ID: E2f1

Z-value: 5.694


Transcription factors associated with E2f1:

Gene SymbolEntrez IDGene Name
E2f1 ENSMUSG00000027490.11 E2f1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f1mm10_v2_chr2_-_154569720_1545697990.866.2e-17Click!


Activity profile for motif E2f1.

activity profile for motif E2f1


Sorted Z-values histogram for motif E2f1

Sorted Z-values for motif E2f1



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_60893430 163.087 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr15_-_98004634 87.789 ENSMUST00000131560.1
ENSMUST00000088355.5
 Col2a1

collagen, type II, alpha 1

chr15_-_98004695 87.554 ENSMUST00000023123.8
 Col2a1
collagen, type II, alpha 1
chr14_-_79301623 72.031 ENSMUST00000022595.7
 Rgcc
regulator of cell cycle
chr1_-_20820213 66.218 ENSMUST00000053266.9
 Mcm3
minichromosome maintenance deficient 3 (S. cerevisiae)
chr17_+_56303396 60.308 ENSMUST00000113038.1
 Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr13_-_23761223 56.291 ENSMUST00000102964.2
 Hist1h4a
histone cluster 1, H4a
chr17_+_56303321 53.291 ENSMUST00000001258.8
 Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr10_-_128704978 51.192 ENSMUST00000026416.7
ENSMUST00000026415.7
 Cdk2

cyclin-dependent kinase 2

chr5_+_45669907 47.935 ENSMUST00000117396.1
 Ncapg
non-SMC condensin I complex, subunit G
chr19_+_36409719 46.064 ENSMUST00000062389.5
 Pcgf5
polycomb group ring finger 5
chr10_-_78591945 45.790 ENSMUST00000040580.6
 Syde1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr2_+_163054682 44.891 ENSMUST00000018005.3
 Mybl2
myeloblastosis oncogene-like 2
chr11_+_98907801 44.106 ENSMUST00000092706.6
 Cdc6
cell division cycle 6
chrY_+_90784738 43.988 ENSMUST00000179483.1
 Erdr1
erythroid differentiation regulator 1
chr4_+_126556935 43.280 ENSMUST00000048391.8
 Clspn
claspin
chrX_+_170009659 43.070 ENSMUST00000179760.1
 Gm21887
predicted gene, 21887
chr14_-_103843685 41.476 ENSMUST00000172237.1
 Ednrb
endothelin receptor type B
chr10_-_120476469 40.718 ENSMUST00000072777.7
ENSMUST00000159699.1
 Hmga2

high mobility group AT-hook 2

chrX_+_170009892 40.685 ENSMUST00000180251.1
 Gm21887
predicted gene, 21887

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 476 entries
Log-likelihood per target Total log-likelihoodTermDescription
7.3 249.2 GO:0006270 DNA replication initiation(GO:0006270)
15.7 188.6 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
10.5 157.3 GO:0010216 maintenance of DNA methylation(GO:0010216)
7.4 155.2 GO:0007530 sex determination(GO:0007530)
6.6 124.8 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
6.0 108.1 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
4.8 100.6 GO:0040034 regulation of development, heterochronic(GO:0040034)
12.8 89.8 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
5.7 85.8 GO:0007076 mitotic chromosome condensation(GO:0007076)
4.1 77.3 GO:0030261 chromosome condensation(GO:0030261)
14.9 74.4 GO:2001032 regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
17.8 71.2 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
14.2 70.8 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
8.8 70.3 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
9.6 67.0 GO:0098535 de novo centriole assembly(GO:0098535)
1.5 66.2 GO:0035019 somatic stem cell population maintenance(GO:0035019)
2.0 64.9 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
20.7 62.1 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
19.7 59.0 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
1.3 55.1 GO:0051310 metaphase plate congression(GO:0051310)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 205 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 685.3 GO:0005634 nucleus(GO:0005634)
3.4 215.4 GO:0005657 replication fork(GO:0005657)
0.5 213.1 GO:0000228 nuclear chromosome(GO:0000228)
14.8 177.3 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
4.4 145.1 GO:0000788 nuclear nucleosome(GO:0000788)
0.9 142.5 GO:0000775 chromosome, centromeric region(GO:0000775)
10.5 136.5 GO:0042555 MCM complex(GO:0042555)
1.1 113.4 GO:0005814 centriole(GO:0005814)
9.7 97.5 GO:0000796 condensin complex(GO:0000796)
18.2 90.9 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
2.1 81.6 GO:0060077 inhibitory synapse(GO:0060077)
22.9 68.7 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
3.2 64.7 GO:0035098 ESC/E(Z) complex(GO:0035098)
10.3 61.7 GO:0098536 deuterosome(GO:0098536)
1.3 60.2 GO:0031519 PcG protein complex(GO:0031519)
0.3 58.9 GO:0005667 transcription factor complex(GO:0005667)
0.3 57.9 GO:0005681 spliceosomal complex(GO:0005681)
1.6 52.9 GO:0046658 anchored component of plasma membrane(GO:0046658)
9.4 47.1 GO:0031523 Myb complex(GO:0031523)
0.2 46.8 GO:0009897 external side of plasma membrane(GO:0009897)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 283 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 310.0 GO:0042393 histone binding(GO:0042393)
35.1 175.3 GO:0042289 MHC class II protein binding(GO:0042289)
4.4 163.1 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
32.7 130.6 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
1.2 124.0 GO:0004386 helicase activity(GO:0004386)
0.8 119.4 GO:0001047 core promoter binding(GO:0001047)
2.3 112.0 GO:0003678 DNA helicase activity(GO:0003678)
2.9 94.5 GO:0070412 R-SMAD binding(GO:0070412)
18.2 90.9 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
11.5 80.8 GO:0004351 glutamate decarboxylase activity(GO:0004351)
4.4 70.8 GO:0003680 AT DNA binding(GO:0003680)
11.8 70.7 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.4 70.2 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
1.7 67.8 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.3 65.0 GO:0003682 chromatin binding(GO:0003682)
1.0 62.7 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
1.7 61.4 GO:0017025 TBP-class protein binding(GO:0017025)
14.6 58.3 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
4.5 53.5 GO:0035173 histone kinase activity(GO:0035173)
4.8 52.5 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.0 321.2 PID_E2F_PATHWAY E2F transcription factor network
5.3 243.3 PID_ATR_PATHWAY ATR signaling pathway
3.8 209.6 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
3.9 189.5 PID_AURORA_B_PATHWAY Aurora B signaling
7.0 98.3 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
3.0 94.5 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
1.4 84.1 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.8 81.2 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.9 77.7 PID_AR_PATHWAY Coregulation of Androgen receptor activity
1.1 56.2 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
1.6 54.7 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.5 54.2 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
1.5 44.9 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.9 31.8 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.6 29.8 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.7 28.6 PID_BMP_PATHWAY BMP receptor signaling
0.6 25.0 PID_PLK1_PATHWAY PLK1 signaling events
0.8 24.5 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.7 23.1 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.4 20.1 PID_CMYB_PATHWAY C-MYB transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 115 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.6 252.2 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
10.1 162.4 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
3.4 161.0 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
8.8 158.6 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
8.2 139.3 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
7.1 92.6 REACTOME_PROCESSIVE_SYNTHESIS_ON_THE_LAGGING_STRAND Genes involved in Processive synthesis on the lagging strand
3.9 90.5 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
3.9 89.8 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.9 66.9 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.8 63.9 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.3 54.7 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
2.2 53.3 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.4 44.4 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
4.0 44.1 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
2.1 42.5 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
2.3 38.7 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
1.4 38.5 REACTOME_KINESINS Genes involved in Kinesins
1.0 37.2 REACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION Genes involved in Nuclear Events (kinase and transcription factor activation)
4.6 36.7 REACTOME_ACYL_CHAIN_REMODELLING_OF_PI Genes involved in Acyl chain remodelling of PI
5.0 35.3 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway