Motif ID: E2f2_E2f5

Z-value: 4.419

Transcription factors associated with E2f2_E2f5:

Gene SymbolEntrez IDGene Name
E2f2 ENSMUSG00000018983.9 E2f2
E2f5 ENSMUSG00000027552.8 E2f5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f2mm10_v2_chr4_+_136172367_1361723950.961.4e-31Click!
E2f5mm10_v2_chr3_+_14578609_145786870.911.7e-21Click!


Activity profile for motif E2f2_E2f5.

activity profile for motif E2f2_E2f5


Sorted Z-values histogram for motif E2f2_E2f5

Sorted Z-values for motif E2f2_E2f5



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f2_E2f5

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_136172367 92.636 ENSMUST00000061721.5
 E2f2
E2F transcription factor 2
chr2_-_157204483 86.339 ENSMUST00000029170.7
 Rbl1
retinoblastoma-like 1 (p107)
chr10_-_69352886 86.303 ENSMUST00000119827.1
ENSMUST00000020099.5
 Cdk1

cyclin-dependent kinase 1

chr5_+_139543889 75.970 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr4_+_126556935 71.290 ENSMUST00000048391.8
 Clspn
claspin
chr17_+_56304313 69.491 ENSMUST00000113035.1
ENSMUST00000113039.2
ENSMUST00000142387.1
 Uhrf1


ubiquitin-like, containing PHD and RING finger domains, 1


chr13_-_24761440 69.222 ENSMUST00000176890.1
ENSMUST00000175689.1
 Gmnn

geminin

chr13_-_24761861 68.341 ENSMUST00000006898.3
ENSMUST00000110382.2
 Gmnn

geminin

chr9_+_122951051 64.714 ENSMUST00000040717.5
 Kif15
kinesin family member 15
chr1_-_20820213 61.789 ENSMUST00000053266.9
 Mcm3
minichromosome maintenance deficient 3 (S. cerevisiae)
chr12_+_24708241 60.788 ENSMUST00000020980.5
 Rrm2
ribonucleotide reductase M2
chr2_+_72476159 58.578 ENSMUST00000102691.4
 Cdca7
cell division cycle associated 7
chr13_-_55329723 55.626 ENSMUST00000021941.7
 Mxd3
Max dimerization protein 3
chr2_+_72476225 55.601 ENSMUST00000157019.1
 Cdca7
cell division cycle associated 7
chr3_+_98013503 53.482 ENSMUST00000079812.6
 Notch2
notch 2
chr2_-_113848655 52.195 ENSMUST00000102545.1
ENSMUST00000110948.1
 Arhgap11a

Rho GTPase activating protein 11A

chr8_+_75109528 48.955 ENSMUST00000164309.1
 Mcm5
minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
chr2_-_113848601 48.251 ENSMUST00000110949.2
 Arhgap11a
Rho GTPase activating protein 11A
chr15_-_58135047 47.144 ENSMUST00000038194.3
 Atad2
ATPase family, AAA domain containing 2
chr4_+_126556994 46.581 ENSMUST00000147675.1
 Clspn
claspin

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 169 entries
Log-likelihood per target Total log-likelihoodTermDescription
7.7 216.6 GO:0006270 DNA replication initiation(GO:0006270)
2.5 165.0 GO:0008156 negative regulation of DNA replication(GO:0008156)
19.9 139.0 GO:1990086 lens fiber cell apoptotic process(GO:1990086)
12.6 125.9 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
8.8 123.8 GO:0090308 regulation of methylation-dependent chromatin silencing(GO:0090308)
6.0 101.9 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
10.7 95.9 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
31.9 95.6 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
1.9 83.6 GO:0043550 regulation of lipid kinase activity(GO:0043550)
9.0 81.2 GO:0090166 Golgi disassembly(GO:0090166)
8.5 76.6 GO:0033504 floor plate development(GO:0033504)
9.5 76.0 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.8 71.4 GO:0006342 chromatin silencing(GO:0006342)
17.8 53.5 GO:0035622 intrahepatic bile duct development(GO:0035622) cholangiocyte proliferation(GO:1990705)
12.8 51.3 GO:0006272 leading strand elongation(GO:0006272)
5.4 48.8 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.3 48.4 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
7.9 47.1 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
14.0 42.1 GO:0051105 regulation of DNA ligation(GO:0051105) positive regulation of DNA ligation(GO:0051106)
8.3 41.6 GO:1901731 positive regulation of platelet aggregation(GO:1901731)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 82 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 372.6 GO:0005634 nucleus(GO:0005634)
15.0 224.3 GO:0042555 MCM complex(GO:0042555)
3.4 185.9 GO:0005657 replication fork(GO:0005657)
0.6 169.4 GO:0005667 transcription factor complex(GO:0005667)
1.1 161.1 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
20.4 101.9 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
1.7 94.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
1.3 92.9 GO:0044815 nucleosome(GO:0000786) DNA packaging complex(GO:0044815)
0.8 85.6 GO:0005814 centriole(GO:0005814)
1.1 70.1 GO:0005871 kinesin complex(GO:0005871)
0.2 70.0 GO:0005694 chromosome(GO:0005694)
8.8 61.5 GO:0031298 replication fork protection complex(GO:0031298)
2.8 47.8 GO:0000800 lateral element(GO:0000800)
9.3 46.3 GO:0035189 Rb-E2F complex(GO:0035189)
8.7 43.4 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
4.6 41.6 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
4.5 40.5 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.1 39.8 GO:0043235 receptor complex(GO:0043235)
7.3 36.4 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.2 28.7 GO:0000775 chromosome, centromeric region(GO:0000775)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 123 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 220.8 GO:0001047 core promoter binding(GO:0001047)
9.3 130.8 GO:0003688 DNA replication origin binding(GO:0003688)
1.5 123.4 GO:0070491 repressing transcription factor binding(GO:0070491)
30.3 121.1 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
19.6 117.9 GO:0010997 anaphase-promoting complex binding(GO:0010997)
3.0 103.9 GO:1990841 promoter-specific chromatin binding(GO:1990841)
20.4 101.9 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
6.6 99.1 GO:0035173 histone kinase activity(GO:0035173)
0.2 97.9 GO:0000975 regulatory region DNA binding(GO:0000975) transcription regulatory region DNA binding(GO:0044212)
0.8 88.4 GO:0004386 helicase activity(GO:0004386)
0.3 87.2 GO:0005096 GTPase activator activity(GO:0005096)
3.4 84.4 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.8 70.1 GO:0003777 microtubule motor activity(GO:0003777)
1.4 63.8 GO:0003678 DNA helicase activity(GO:0003678)
0.1 62.1 GO:0003677 DNA binding(GO:0003677)
0.5 57.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.3 55.8 GO:0042393 histone binding(GO:0042393)
7.7 53.7 GO:0000150 recombinase activity(GO:0000150)
1.4 53.5 GO:0051059 NF-kappaB binding(GO:0051059)
0.2 51.7 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.5 363.2 PID_E2F_PATHWAY E2F transcription factor network
6.8 297.3 PID_ATR_PATHWAY ATR signaling pathway
11.6 162.4 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
16.6 149.0 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
1.2 119.5 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
2.4 76.6 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
1.4 72.3 PID_PLK1_PATHWAY PLK1 signaling events
0.8 62.4 PID_NOTCH_PATHWAY Notch signaling pathway
1.8 45.7 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.6 29.3 PID_IL4_2PATHWAY IL4-mediated signaling events
0.6 27.8 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.6 16.5 PID_FANCONI_PATHWAY Fanconi anemia pathway
1.3 16.3 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.7 13.2 PID_CD40_PATHWAY CD40/CD40L signaling
0.4 11.9 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.2 10.9 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.4 10.3 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.3 10.1 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.2 9.0 PID_ERBB4_PATHWAY ErbB4 signaling events
0.2 8.9 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
19.7 393.0 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
17.4 244.3 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
20.9 230.2 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.6 99.8 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
6.9 96.1 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
5.6 94.4 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
1.6 92.8 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
7.3 66.0 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
2.4 64.7 REACTOME_KINESINS Genes involved in Kinesins
5.3 58.0 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
4.7 55.8 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
2.4 48.8 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
5.3 32.0 REACTOME_DNA_STRAND_ELONGATION Genes involved in DNA strand elongation
1.1 31.0 REACTOME_G1_PHASE Genes involved in G1 Phase
3.6 18.1 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex
0.1 18.1 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2 17.1 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.2 16.8 REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE Genes involved in Late Phase of HIV Life Cycle
3.9 15.8 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.4 14.1 REACTOME_RNA_POL_I_TRANSCRIPTION Genes involved in RNA Polymerase I Transcription