Motif ID: E2f3
Z-value: 1.171
Transcription factors associated with E2f3:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| E2f3 | ENSMUSG00000016477.11 | E2f3 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2f3 | mm10_v2_chr13_-_29984219_29984353 | 0.51 | 8.2e-05 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.3 | 9.9 | GO:2000620 | positive regulation of histone H4-K16 acetylation(GO:2000620) |
| 3.1 | 9.2 | GO:2000373 | regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373) |
| 1.9 | 13.0 | GO:0010032 | meiotic chromosome condensation(GO:0010032) |
| 1.7 | 5.2 | GO:0035934 | corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852) |
| 1.2 | 4.9 | GO:0035624 | mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025) receptor transactivation(GO:0035624) epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway(GO:0035625) response to high density lipoprotein particle(GO:0055099) |
| 1.2 | 6.0 | GO:0010792 | DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) |
| 1.0 | 3.1 | GO:0030200 | heparan sulfate proteoglycan catabolic process(GO:0030200) |
| 1.0 | 3.1 | GO:0007161 | calcium-independent cell-matrix adhesion(GO:0007161) |
| 1.0 | 8.7 | GO:0033504 | floor plate development(GO:0033504) |
| 0.9 | 5.1 | GO:0042276 | error-prone translesion synthesis(GO:0042276) |
| 0.8 | 5.7 | GO:0033567 | DNA replication, Okazaki fragment processing(GO:0033567) |
| 0.7 | 4.4 | GO:0030214 | hyaluronan catabolic process(GO:0030214) |
| 0.7 | 2.0 | GO:0010752 | negative regulation of antigen processing and presentation(GO:0002578) negative regulation of nitric oxide mediated signal transduction(GO:0010751) regulation of cGMP-mediated signaling(GO:0010752) |
| 0.7 | 2.0 | GO:0006295 | nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295) |
| 0.6 | 7.5 | GO:0051307 | meiotic chromosome separation(GO:0051307) |
| 0.6 | 13.0 | GO:0043486 | histone exchange(GO:0043486) |
| 0.6 | 1.7 | GO:0090204 | protein localization to nuclear pore(GO:0090204) negative regulation of vascular endothelial growth factor production(GO:1904046) |
| 0.6 | 3.9 | GO:0044806 | G-quadruplex DNA unwinding(GO:0044806) |
| 0.5 | 1.6 | GO:0019085 | early viral transcription(GO:0019085) |
| 0.5 | 3.7 | GO:0070863 | positive regulation of protein exit from endoplasmic reticulum(GO:0070863) |
| 0.5 | 5.7 | GO:2000051 | negative regulation of non-canonical Wnt signaling pathway(GO:2000051) |
| 0.5 | 2.6 | GO:0090245 | axis elongation involved in somitogenesis(GO:0090245) |
| 0.5 | 1.9 | GO:0055071 | cellular manganese ion homeostasis(GO:0030026) Golgi calcium ion homeostasis(GO:0032468) manganese ion homeostasis(GO:0055071) |
| 0.4 | 1.8 | GO:0006420 | arginyl-tRNA aminoacylation(GO:0006420) |
| 0.4 | 3.0 | GO:0019985 | translesion synthesis(GO:0019985) |
| 0.4 | 1.7 | GO:0061428 | embryonic heart tube left/right pattern formation(GO:0060971) negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428) |
| 0.4 | 2.8 | GO:0048478 | replication fork protection(GO:0048478) |
| 0.4 | 7.1 | GO:0072520 | seminiferous tubule development(GO:0072520) |
| 0.4 | 7.1 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 0.4 | 6.2 | GO:0060213 | regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213) |
| 0.4 | 2.3 | GO:0045162 | clustering of voltage-gated sodium channels(GO:0045162) |
| 0.4 | 0.8 | GO:0009957 | epidermal cell fate specification(GO:0009957) |
| 0.4 | 2.6 | GO:0070779 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
| 0.4 | 5.3 | GO:0006312 | mitotic recombination(GO:0006312) |
| 0.3 | 4.1 | GO:0070445 | oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445) |
| 0.3 | 2.4 | GO:1904217 | regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) regulation of serine C-palmitoyltransferase activity(GO:1904220) positive regulation of serine C-palmitoyltransferase activity(GO:1904222) |
| 0.3 | 1.6 | GO:0051987 | positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987) |
| 0.3 | 1.6 | GO:0042758 | long-chain fatty acid catabolic process(GO:0042758) |
| 0.3 | 2.6 | GO:0098789 | pre-mRNA cleavage required for polyadenylation(GO:0098789) |
| 0.3 | 4.6 | GO:0033327 | Leydig cell differentiation(GO:0033327) |
| 0.3 | 0.8 | GO:0035622 | intrahepatic bile duct development(GO:0035622) cholangiocyte proliferation(GO:1990705) |
| 0.3 | 1.5 | GO:0060923 | cardiac muscle cell fate commitment(GO:0060923) |
| 0.2 | 2.4 | GO:0035873 | lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879) |
| 0.2 | 1.2 | GO:0061511 | centriole elongation(GO:0061511) |
| 0.2 | 1.9 | GO:0044791 | modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791) |
| 0.2 | 0.7 | GO:1901675 | negative regulation of histone H3-K27 acetylation(GO:1901675) |
| 0.2 | 2.5 | GO:0046784 | viral mRNA export from host cell nucleus(GO:0046784) |
| 0.2 | 1.0 | GO:0003376 | sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520) |
| 0.2 | 3.1 | GO:0036120 | cellular response to platelet-derived growth factor stimulus(GO:0036120) |
| 0.2 | 4.9 | GO:0040034 | regulation of development, heterochronic(GO:0040034) |
| 0.2 | 1.1 | GO:1901837 | negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837) |
| 0.2 | 3.0 | GO:0007131 | reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825) |
| 0.2 | 0.5 | GO:0048633 | positive regulation of skeletal muscle tissue growth(GO:0048633) |
| 0.2 | 0.9 | GO:0006680 | glucosylceramide catabolic process(GO:0006680) |
| 0.2 | 1.9 | GO:0031936 | negative regulation of chromatin silencing(GO:0031936) |
| 0.2 | 0.5 | GO:0071579 | regulation of zinc ion transport(GO:0071579) |
| 0.2 | 1.6 | GO:1904152 | tumor necrosis factor biosynthetic process(GO:0042533) regulation of tumor necrosis factor biosynthetic process(GO:0042534) negative regulation of protein exit from endoplasmic reticulum(GO:0070862) regulation of retrograde protein transport, ER to cytosol(GO:1904152) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153) |
| 0.2 | 2.4 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.2 | 3.8 | GO:0045662 | negative regulation of myoblast differentiation(GO:0045662) |
| 0.1 | 3.8 | GO:0031290 | retinal ganglion cell axon guidance(GO:0031290) |
| 0.1 | 1.5 | GO:0034244 | negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244) |
| 0.1 | 1.3 | GO:1902416 | positive regulation of mRNA binding(GO:1902416) positive regulation of RNA binding(GO:1905216) |
| 0.1 | 2.1 | GO:1901741 | positive regulation of myoblast fusion(GO:1901741) |
| 0.1 | 0.8 | GO:0036337 | Fas signaling pathway(GO:0036337) |
| 0.1 | 5.4 | GO:0001755 | neural crest cell migration(GO:0001755) |
| 0.1 | 0.3 | GO:0035672 | transepithelial chloride transport(GO:0030321) oligopeptide transmembrane transport(GO:0035672) |
| 0.1 | 0.9 | GO:0071802 | negative regulation of podosome assembly(GO:0071802) |
| 0.1 | 0.6 | GO:2000973 | regulation of pro-B cell differentiation(GO:2000973) |
| 0.1 | 2.1 | GO:0090161 | Golgi ribbon formation(GO:0090161) |
| 0.1 | 6.5 | GO:0000266 | mitochondrial fission(GO:0000266) |
| 0.1 | 5.5 | GO:0048384 | retinoic acid receptor signaling pathway(GO:0048384) |
| 0.1 | 0.4 | GO:0000957 | mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960) mitochondrial RNA 3'-end processing(GO:0000965) |
| 0.1 | 0.2 | GO:0045590 | negative regulation of regulatory T cell differentiation(GO:0045590) |
| 0.1 | 0.8 | GO:0000290 | deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290) |
| 0.1 | 1.0 | GO:2000773 | negative regulation of cellular senescence(GO:2000773) |
| 0.1 | 0.3 | GO:1905245 | regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902959) positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) negative regulation of metalloendopeptidase activity(GO:1904684) regulation of aspartic-type peptidase activity(GO:1905245) positive regulation of aspartic-type peptidase activity(GO:1905247) |
| 0.1 | 0.7 | GO:0051152 | positive regulation of smooth muscle cell differentiation(GO:0051152) |
| 0.1 | 0.7 | GO:0035562 | negative regulation of chromatin binding(GO:0035562) |
| 0.1 | 0.4 | GO:1902969 | mitotic DNA replication(GO:1902969) |
| 0.1 | 0.7 | GO:0030206 | chondroitin sulfate biosynthetic process(GO:0030206) |
| 0.1 | 1.0 | GO:0060052 | neurofilament cytoskeleton organization(GO:0060052) |
| 0.1 | 1.1 | GO:0060008 | Sertoli cell differentiation(GO:0060008) |
| 0.1 | 0.9 | GO:2000001 | regulation of DNA damage checkpoint(GO:2000001) |
| 0.1 | 0.2 | GO:0060406 | positive regulation of penile erection(GO:0060406) |
| 0.1 | 2.8 | GO:0033120 | positive regulation of RNA splicing(GO:0033120) |
| 0.1 | 0.7 | GO:0021854 | hypothalamus development(GO:0021854) |
| 0.1 | 0.6 | GO:0033262 | regulation of nuclear cell cycle DNA replication(GO:0033262) |
| 0.1 | 1.0 | GO:0034389 | lipid particle organization(GO:0034389) |
| 0.1 | 0.3 | GO:0046490 | isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate metabolic process(GO:0046490) |
| 0.0 | 0.2 | GO:0048484 | enteric nervous system development(GO:0048484) |
| 0.0 | 1.3 | GO:0071539 | protein localization to centrosome(GO:0071539) |
| 0.0 | 0.7 | GO:0030150 | protein import into mitochondrial matrix(GO:0030150) |
| 0.0 | 1.4 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 0.0 | 1.9 | GO:0008156 | negative regulation of DNA replication(GO:0008156) |
| 0.0 | 0.4 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 0.0 | 2.8 | GO:0097194 | execution phase of apoptosis(GO:0097194) |
| 0.0 | 1.1 | GO:0007638 | mechanosensory behavior(GO:0007638) |
| 0.0 | 2.1 | GO:0035914 | skeletal muscle cell differentiation(GO:0035914) |
| 0.0 | 2.9 | GO:0006888 | ER to Golgi vesicle-mediated transport(GO:0006888) |
| 0.0 | 2.2 | GO:0072164 | ureteric bud development(GO:0001657) mesonephric epithelium development(GO:0072163) mesonephric tubule development(GO:0072164) |
| 0.0 | 0.1 | GO:0032201 | telomere maintenance via semi-conservative replication(GO:0032201) |
| 0.0 | 4.5 | GO:0045930 | negative regulation of mitotic cell cycle(GO:0045930) |
| 0.0 | 3.2 | GO:0048511 | rhythmic process(GO:0048511) |
| 0.0 | 0.8 | GO:0048246 | macrophage chemotaxis(GO:0048246) |
| 0.0 | 0.2 | GO:1901409 | positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
| 0.0 | 0.5 | GO:0070208 | protein heterotrimerization(GO:0070208) |
| 0.0 | 0.8 | GO:0046580 | negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058) |
| 0.0 | 1.2 | GO:0046579 | positive regulation of Ras protein signal transduction(GO:0046579) |
| 0.0 | 1.0 | GO:0034644 | cellular response to UV(GO:0034644) |
| 0.0 | 0.2 | GO:0097067 | cellular response to thyroid hormone stimulus(GO:0097067) |
| 0.0 | 0.1 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
| 0.0 | 0.2 | GO:0030213 | hyaluronan biosynthetic process(GO:0030213) |
| 0.0 | 0.2 | GO:0060033 | anatomical structure regression(GO:0060033) |
| 0.0 | 1.6 | GO:0008033 | tRNA processing(GO:0008033) |
| 0.0 | 0.4 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 0.0 | 1.7 | GO:0032886 | regulation of microtubule-based process(GO:0032886) |
| 0.0 | 0.5 | GO:0031122 | cytoplasmic microtubule organization(GO:0031122) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 9.2 | GO:0000799 | nuclear condensin complex(GO:0000799) |
| 1.9 | 13.0 | GO:0000796 | condensin complex(GO:0000796) |
| 1.6 | 9.9 | GO:0070531 | BRCA1-A complex(GO:0070531) |
| 1.4 | 7.1 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
| 1.4 | 5.4 | GO:0043259 | laminin-10 complex(GO:0043259) |
| 1.0 | 5.1 | GO:0008622 | epsilon DNA polymerase complex(GO:0008622) |
| 1.0 | 7.0 | GO:0005828 | kinetochore microtubule(GO:0005828) |
| 0.7 | 2.0 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.6 | 1.9 | GO:0034679 | integrin alpha2-beta1 complex(GO:0034666) integrin alpha3-beta1 complex(GO:0034667) integrin alpha9-beta1 complex(GO:0034679) |
| 0.5 | 1.9 | GO:0034991 | nuclear meiotic cohesin complex(GO:0034991) |
| 0.4 | 3.0 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
| 0.4 | 2.8 | GO:0031298 | replication fork protection complex(GO:0031298) |
| 0.4 | 1.5 | GO:0032021 | NELF complex(GO:0032021) |
| 0.4 | 2.3 | GO:0000938 | GARP complex(GO:0000938) |
| 0.4 | 0.4 | GO:0000811 | GINS complex(GO:0000811) |
| 0.4 | 1.4 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
| 0.4 | 5.3 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.4 | 1.1 | GO:0034657 | GID complex(GO:0034657) |
| 0.3 | 3.9 | GO:0071598 | neuronal ribonucleoprotein granule(GO:0071598) |
| 0.3 | 0.8 | GO:0035061 | interchromatin granule(GO:0035061) |
| 0.2 | 2.5 | GO:0000347 | THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) |
| 0.2 | 2.3 | GO:0071439 | clathrin complex(GO:0071439) |
| 0.2 | 1.7 | GO:0044613 | nuclear pore central transport channel(GO:0044613) |
| 0.2 | 2.6 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.2 | 1.1 | GO:0001740 | Barr body(GO:0001740) |
| 0.1 | 6.1 | GO:0016592 | mediator complex(GO:0016592) |
| 0.1 | 2.8 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
| 0.1 | 1.6 | GO:0008024 | cyclin/CDK positive transcription elongation factor complex(GO:0008024) |
| 0.1 | 2.8 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.1 | 1.6 | GO:1990023 | mitotic spindle midzone(GO:1990023) |
| 0.1 | 0.3 | GO:0000110 | nucleotide-excision repair factor 1 complex(GO:0000110) |
| 0.1 | 0.3 | GO:0070381 | endosome to plasma membrane transport vesicle(GO:0070381) |
| 0.1 | 2.8 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.1 | 11.6 | GO:0005814 | centriole(GO:0005814) |
| 0.1 | 1.3 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.1 | 0.8 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
| 0.1 | 2.1 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 0.1 | 0.7 | GO:0005744 | mitochondrial inner membrane presequence translocase complex(GO:0005744) |
| 0.1 | 0.4 | GO:0034715 | U7 snRNP(GO:0005683) pICln-Sm protein complex(GO:0034715) |
| 0.1 | 0.8 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
| 0.1 | 5.9 | GO:0072686 | mitotic spindle(GO:0072686) |
| 0.1 | 0.4 | GO:0000120 | RNA polymerase I transcription factor complex(GO:0000120) |
| 0.1 | 1.3 | GO:0045120 | pronucleus(GO:0045120) |
| 0.1 | 2.6 | GO:0030673 | axolemma(GO:0030673) |
| 0.1 | 6.0 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.1 | 1.3 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.1 | 0.8 | GO:0016442 | RISC complex(GO:0016442) RNAi effector complex(GO:0031332) |
| 0.1 | 5.8 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.1 | 0.8 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.0 | 2.5 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.0 | 1.9 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 2.4 | GO:0000794 | condensed nuclear chromosome(GO:0000794) |
| 0.0 | 1.2 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 1.5 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 0.5 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.0 | 4.7 | GO:0044798 | nuclear transcription factor complex(GO:0044798) |
| 0.0 | 0.4 | GO:0042555 | MCM complex(GO:0042555) |
| 0.0 | 1.4 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 2.6 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.0 | 1.7 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.0 | 3.7 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 0.4 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.0 | 0.2 | GO:0008540 | proteasome regulatory particle, base subcomplex(GO:0008540) |
| 0.0 | 0.1 | GO:0044530 | supraspliceosomal complex(GO:0044530) |
| 0.0 | 1.2 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 0.5 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.0 | 0.9 | GO:0016363 | nuclear matrix(GO:0016363) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 9.2 | GO:0044547 | DNA topoisomerase binding(GO:0044547) |
| 1.4 | 7.1 | GO:0061731 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 1.3 | 3.8 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 1.1 | 4.4 | GO:0004415 | hyalurononglucosaminidase activity(GO:0004415) |
| 1.0 | 5.7 | GO:0003910 | DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910) |
| 0.7 | 2.0 | GO:0070052 | collagen V binding(GO:0070052) |
| 0.7 | 3.9 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
| 0.6 | 4.9 | GO:0005138 | interleukin-6 receptor binding(GO:0005138) |
| 0.5 | 6.2 | GO:0000014 | single-stranded DNA endodeoxyribonuclease activity(GO:0000014) |
| 0.5 | 3.1 | GO:0045545 | syndecan binding(GO:0045545) |
| 0.5 | 1.9 | GO:0098639 | collagen binding involved in cell-matrix adhesion(GO:0098639) |
| 0.5 | 1.9 | GO:0036033 | mediator complex binding(GO:0036033) |
| 0.5 | 1.9 | GO:0015410 | manganese-transporting ATPase activity(GO:0015410) |
| 0.4 | 1.8 | GO:0004814 | arginine-tRNA ligase activity(GO:0004814) |
| 0.4 | 2.6 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.4 | 7.0 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.4 | 1.2 | GO:0008330 | protein tyrosine/threonine phosphatase activity(GO:0008330) |
| 0.4 | 1.2 | GO:0017150 | tRNA dihydrouridine synthase activity(GO:0017150) |
| 0.4 | 1.6 | GO:0004466 | long-chain-acyl-CoA dehydrogenase activity(GO:0004466) |
| 0.4 | 2.3 | GO:0008821 | crossover junction endodeoxyribonuclease activity(GO:0008821) |
| 0.4 | 1.1 | GO:0019166 | trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166) |
| 0.4 | 4.6 | GO:0016832 | aldehyde-lyase activity(GO:0016832) |
| 0.3 | 1.7 | GO:0000405 | bubble DNA binding(GO:0000405) |
| 0.3 | 2.3 | GO:0000150 | recombinase activity(GO:0000150) |
| 0.3 | 5.5 | GO:0003708 | retinoic acid receptor activity(GO:0003708) |
| 0.3 | 5.2 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.3 | 0.8 | GO:0005119 | smoothened binding(GO:0005119) hedgehog receptor activity(GO:0008158) |
| 0.3 | 0.8 | GO:0004534 | 5'-3' exoribonuclease activity(GO:0004534) |
| 0.2 | 1.7 | GO:0050693 | LBD domain binding(GO:0050693) |
| 0.2 | 0.9 | GO:0070976 | calcium-independent protein kinase C activity(GO:0004699) TIR domain binding(GO:0070976) |
| 0.2 | 1.6 | GO:0097322 | 7SK snRNA binding(GO:0097322) |
| 0.2 | 0.8 | GO:0031727 | CCR2 chemokine receptor binding(GO:0031727) |
| 0.2 | 5.1 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.2 | 9.9 | GO:0003684 | damaged DNA binding(GO:0003684) |
| 0.2 | 0.5 | GO:0004711 | ribosomal protein S6 kinase activity(GO:0004711) |
| 0.2 | 3.7 | GO:0015035 | protein disulfide oxidoreductase activity(GO:0015035) |
| 0.2 | 2.4 | GO:0022889 | L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889) |
| 0.2 | 1.3 | GO:0097157 | pre-mRNA intronic binding(GO:0097157) mRNA CDS binding(GO:1990715) |
| 0.2 | 0.7 | GO:0034481 | chondroitin sulfotransferase activity(GO:0034481) |
| 0.1 | 1.0 | GO:0050733 | RS domain binding(GO:0050733) |
| 0.1 | 12.1 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.1 | 9.3 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.1 | 1.0 | GO:0038036 | sphingosine-1-phosphate receptor activity(GO:0038036) |
| 0.1 | 6.1 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.1 | 9.0 | GO:0005249 | voltage-gated potassium channel activity(GO:0005249) |
| 0.1 | 0.8 | GO:0032184 | SUMO polymer binding(GO:0032184) |
| 0.1 | 0.7 | GO:0061665 | SUMO ligase activity(GO:0061665) |
| 0.1 | 0.7 | GO:0015450 | P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450) |
| 0.1 | 1.9 | GO:0030506 | ankyrin binding(GO:0030506) |
| 0.1 | 1.9 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.1 | 3.1 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.1 | 0.3 | GO:0015563 | uptake transmembrane transporter activity(GO:0015563) |
| 0.1 | 0.2 | GO:0031686 | A1 adenosine receptor binding(GO:0031686) |
| 0.1 | 0.4 | GO:0004809 | tRNA (guanine-N2-)-methyltransferase activity(GO:0004809) |
| 0.1 | 0.7 | GO:0070181 | small ribosomal subunit rRNA binding(GO:0070181) |
| 0.1 | 2.2 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
| 0.1 | 0.4 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.1 | 0.7 | GO:1990825 | sequence-specific mRNA binding(GO:1990825) |
| 0.1 | 11.4 | GO:0042393 | histone binding(GO:0042393) |
| 0.1 | 2.3 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.1 | 1.2 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 0.1 | 4.1 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.0 | 4.2 | GO:0043565 | sequence-specific DNA binding(GO:0043565) |
| 0.0 | 0.4 | GO:0043138 | 3'-5' DNA helicase activity(GO:0043138) |
| 0.0 | 13.9 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.0 | 4.3 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 0.4 | GO:0001013 | RNA polymerase I regulatory region DNA binding(GO:0001013) RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164) |
| 0.0 | 0.5 | GO:0019855 | calcium channel inhibitor activity(GO:0019855) |
| 0.0 | 0.3 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.0 | 0.7 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.0 | 0.9 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.0 | 1.1 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.0 | 0.8 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.0 | 0.3 | GO:0008430 | selenium binding(GO:0008430) |
| 0.0 | 0.4 | GO:0003678 | DNA helicase activity(GO:0003678) |
| 0.0 | 2.1 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 1.1 | GO:0031490 | chromatin DNA binding(GO:0031490) |
| 0.0 | 0.3 | GO:0016863 | intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863) |
| 0.0 | 1.6 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
| 0.0 | 21.5 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.0 | 3.4 | GO:0003690 | double-stranded DNA binding(GO:0003690) |
| 0.0 | 0.7 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.0 | 0.1 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.0 | 0.8 | GO:0004497 | monooxygenase activity(GO:0004497) |
| 0.0 | 0.2 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 5.4 | PID_INTEGRIN4_PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.5 | 22.2 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 0.4 | 18.2 | PID_ATM_PATHWAY | ATM pathway |
| 0.3 | 11.1 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.3 | 5.5 | PID_S1P_META_PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.2 | 4.7 | PID_SYNDECAN_4_PATHWAY | Syndecan-4-mediated signaling events |
| 0.1 | 3.8 | PID_NECTIN_PATHWAY | Nectin adhesion pathway |
| 0.1 | 5.1 | PID_WNT_NONCANONICAL_PATHWAY | Noncanonical Wnt signaling pathway |
| 0.1 | 3.7 | PID_ATR_PATHWAY | ATR signaling pathway |
| 0.1 | 7.3 | PID_E2F_PATHWAY | E2F transcription factor network |
| 0.1 | 4.9 | PID_ERBB4_PATHWAY | ErbB4 signaling events |
| 0.1 | 3.0 | ST_ERK1_ERK2_MAPK_PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.1 | 0.8 | SA_PROGRAMMED_CELL_DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.1 | 0.7 | ST_JAK_STAT_PATHWAY | Jak-STAT Pathway |
| 0.0 | 1.7 | PID_HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 3.4 | PID_ERA_GENOMIC_PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 1.4 | PID_ANGIOPOIETIN_RECEPTOR_PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.0 | 2.8 | PID_SMAD2_3NUCLEAR_PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 1.2 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 2.2 | PID_NOTCH_PATHWAY | Notch signaling pathway |
| 0.0 | 3.9 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 0.9 | PID_REELIN_PATHWAY | Reelin signaling pathway |
| 0.0 | 1.0 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 16.4 | REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.4 | 5.1 | REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER | Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER |
| 0.4 | 8.0 | REACTOME_G1_S_SPECIFIC_TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.4 | 5.7 | REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.3 | 7.2 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.2 | 9.0 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.2 | 11.3 | REACTOME_MEIOTIC_RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.2 | 3.1 | REACTOME_PECAM1_INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.2 | 1.9 | REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.2 | 2.4 | REACTOME_ERKS_ARE_INACTIVATED | Genes involved in ERKs are inactivated |
| 0.1 | 3.1 | REACTOME_HS_GAG_DEGRADATION | Genes involved in HS-GAG degradation |
| 0.1 | 1.4 | REACTOME_PROLACTIN_RECEPTOR_SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.1 | 4.6 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.1 | 2.0 | REACTOME_GLOBAL_GENOMIC_NER_GG_NER | Genes involved in Global Genomic NER (GG-NER) |
| 0.1 | 7.5 | REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 1.6 | REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.1 | 5.5 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 1.8 | REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.1 | 0.7 | REACTOME_REGULATION_OF_IFNG_SIGNALING | Genes involved in Regulation of IFNG signaling |
| 0.1 | 5.2 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 0.7 | REACTOME_UNWINDING_OF_DNA | Genes involved in Unwinding of DNA |
| 0.0 | 1.9 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 1.9 | REACTOME_MEIOTIC_SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.0 | 1.6 | REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.0 | 0.8 | REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.0 | 1.3 | REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
| 0.0 | 0.6 | REACTOME_ACTIVATION_OF_RAC | Genes involved in Activation of Rac |
| 0.0 | 5.3 | REACTOME_MRNA_SPLICING | Genes involved in mRNA Splicing |
| 0.0 | 1.9 | REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.0 | 2.8 | REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 0.5 | REACTOME_MTORC1_MEDIATED_SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.0 | 0.9 | REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.0 | 0.7 | REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.0 | 0.5 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 0.2 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
| 0.0 | 0.4 | REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |
| 0.0 | 1.6 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 0.3 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 0.7 | REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.0 | 0.9 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 0.2 | REACTOME_SIGNALING_BY_HIPPO | Genes involved in Signaling by Hippo |
| 0.0 | 0.2 | REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
