Motif ID: E2f4

Z-value: 2.997


Transcription factors associated with E2f4:

Gene SymbolEntrez IDGene Name
E2f4 ENSMUSG00000014859.8 E2f4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f4mm10_v2_chr8_+_105297663_1052977420.915.6e-22Click!


Activity profile for motif E2f4.

activity profile for motif E2f4


Sorted Z-values histogram for motif E2f4

Sorted Z-values for motif E2f4



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f4

PNG image of the network

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Top targets:


Showing 1 to 20 of 164 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_6084983 47.197 ENSMUST00000025704.2
 Cdca5
cell division cycle associated 5
chr18_-_34751502 45.957 ENSMUST00000060710.7
 Cdc25c
cell division cycle 25C
chr4_+_134510999 41.761 ENSMUST00000105866.2
 Aunip
aurora kinase A and ninein interacting protein
chr14_-_47418407 41.239 ENSMUST00000043296.3
 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr6_+_124830217 40.673 ENSMUST00000131847.1
ENSMUST00000151674.1
 Cdca3

cell division cycle associated 3

chr1_-_169531343 38.944 ENSMUST00000028000.7
 Nuf2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr8_-_53638945 36.202 ENSMUST00000047768.4
 Neil3
nei like 3 (E. coli)
chr9_+_72438534 35.711 ENSMUST00000034746.8
 Mns1
meiosis-specific nuclear structural protein 1
chr1_-_169531447 34.073 ENSMUST00000111368.1
 Nuf2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr1_-_189688074 34.069 ENSMUST00000171929.1
ENSMUST00000165962.1
 Cenpf

centromere protein F

chr9_+_72438519 33.509 ENSMUST00000184604.1
 Mns1
meiosis-specific nuclear structural protein 1
chr4_-_132345686 33.155 ENSMUST00000030726.6
 Rcc1
regulator of chromosome condensation 1
chr18_+_34751803 31.643 ENSMUST00000181453.1
ENSMUST00000181641.1
 2010110K18Rik

RIKEN cDNA 2010110K18 gene

chr11_-_101551837 31.513 ENSMUST00000017290.4
 Brca1
breast cancer 1
chr4_-_132345715 31.505 ENSMUST00000084250.4
 Rcc1
regulator of chromosome condensation 1
chr2_+_163054682 29.852 ENSMUST00000018005.3
 Mybl2
myeloblastosis oncogene-like 2
chr2_-_26503814 29.184 ENSMUST00000028288.4
 Notch1
notch 1
chr12_+_117843873 28.316 ENSMUST00000176735.1
ENSMUST00000177339.1
 Cdca7l

cell division cycle associated 7 like

chr4_-_58553553 27.811 ENSMUST00000107575.2
ENSMUST00000107574.1
ENSMUST00000147354.1
 Lpar1


lysophosphatidic acid receptor 1


chr1_+_157412352 27.030 ENSMUST00000061537.5
 2810025M15Rik
RIKEN cDNA 2810025M15 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 98 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 83.0 GO:0051290 protein heterotetramerization(GO:0051290)
2.0 73.0 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
2.9 72.8 GO:0040034 regulation of development, heterochronic(GO:0040034)
5.1 72.0 GO:0070986 left/right axis specification(GO:0070986)
17.1 68.5 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.1 54.5 GO:0051301 cell division(GO:0051301)
1.9 51.2 GO:0008340 determination of adult lifespan(GO:0008340)
15.7 47.2 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
1.9 46.0 GO:1902751 positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.4 36.5 GO:0007051 spindle organization(GO:0007051)
0.8 36.2 GO:0006284 base-excision repair(GO:0006284)
3.9 35.0 GO:0055059 asymmetric neuroblast division(GO:0055059)
1.0 34.1 GO:0051310 metaphase plate congression(GO:0051310)
2.2 33.3 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
10.5 31.5 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
0.7 29.9 GO:0090307 mitotic spindle assembly(GO:0090307)
9.7 29.2 GO:0003219 atrioventricular node development(GO:0003162) cardiac right ventricle formation(GO:0003219)
0.5 26.6 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
8.7 26.1 GO:0061144 alveolar secondary septum development(GO:0061144)
1.1 23.8 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 86.1 GO:0005634 nucleus(GO:0005634)
12.2 73.0 GO:0031262 Ndc80 complex(GO:0031262)
1.1 72.8 GO:0005882 intermediate filament(GO:0005882)
0.6 67.4 GO:0043198 dendritic shaft(GO:0043198)
0.9 65.1 GO:0000794 condensed nuclear chromosome(GO:0000794)
6.7 47.2 GO:0008278 cohesin complex(GO:0008278)
0.5 41.8 GO:0000922 spindle pole(GO:0000922)
2.1 41.2 GO:0031616 spindle pole centrosome(GO:0031616)
0.6 41.1 GO:0000786 nucleosome(GO:0000786)
2.8 34.1 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.3 32.6 GO:0005913 cell-cell adherens junction(GO:0005913)
5.3 31.5 GO:0070531 BRCA1-A complex(GO:0070531)
6.0 29.9 GO:0031523 Myb complex(GO:0031523)
0.3 29.8 GO:0005814 centriole(GO:0005814)
5.8 29.2 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
2.8 28.3 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 27.9 GO:0005667 transcription factor complex(GO:0005667)
3.7 26.1 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.2 25.1 GO:0000775 chromosome, centromeric region(GO:0000775)
0.4 23.8 GO:0005643 nuclear pore(GO:0005643)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
9.8 68.5 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
10.8 64.7 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.3 51.3 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
1.3 46.0 GO:0050699 WW domain binding(GO:0050699)
0.0 43.7 GO:0042802 identical protein binding(GO:0042802)
0.9 41.1 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.2 40.4 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
7.2 36.2 GO:0000405 bubble DNA binding(GO:0000405)
0.6 35.0 GO:0003684 damaged DNA binding(GO:0003684)
1.0 34.1 GO:0070840 dynein complex binding(GO:0070840)
0.1 31.2 GO:0003682 chromatin binding(GO:0003682)
3.7 29.9 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.8 29.2 GO:0005112 Notch binding(GO:0005112)
2.6 26.3 GO:0036310 annealing helicase activity(GO:0036310)
2.9 26.1 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.1 24.7 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.8 23.8 GO:0008139 nuclear localization sequence binding(GO:0008139)
2.1 23.0 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
3.0 20.7 GO:0015616 DNA translocase activity(GO:0015616)
1.9 19.4 GO:0070700 BMP receptor binding(GO:0070700)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 94.9 PID_ATM_PATHWAY ATM pathway
0.8 68.5 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.7 68.3 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.7 46.3 PID_E2F_PATHWAY E2F transcription factor network
1.0 41.2 PID_AURORA_A_PATHWAY Aurora A signaling
1.1 36.8 PID_FOXM1_PATHWAY FOXM1 transcription factor network
1.1 31.1 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.7 28.4 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.4 26.1 PID_FGF_PATHWAY FGF signaling pathway
1.8 19.4 PID_ALK2_PATHWAY ALK2 signaling events
1.3 18.3 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.5 13.0 ST_GAQ_PATHWAY G alpha q Pathway
0.4 12.1 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.3 9.6 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 7.9 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.2 7.2 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.3 6.9 PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY EGF receptor (ErbB1) signaling pathway
0.1 6.1 PID_LKB1_PATHWAY LKB1 signaling events
0.2 5.8 PID_RHOA_PATHWAY RhoA signaling pathway
0.2 4.9 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 98.6 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.7 66.8 REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE Genes involved in Late Phase of HIV Life Cycle
2.6 66.1 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.5 61.5 REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
2.5 53.3 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
4.6 46.0 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.9 44.6 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
1.1 35.0 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
1.6 27.3 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
2.9 26.1 REACTOME_SIGNALING_BY_FGFR3_MUTANTS Genes involved in Signaling by FGFR3 mutants
0.5 22.1 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
1.2 12.9 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.3 12.1 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.9 11.2 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.3 9.6 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.3 8.4 REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.5 7.0 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.5 6.9 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.3 5.4 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.6 4.9 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION_IN_TLR7_8_OR_9_SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling