Motif ID: E2f7

Z-value: 1.621


Transcription factors associated with E2f7:

Gene SymbolEntrez IDGene Name
E2f7 ENSMUSG00000020185.10 E2f7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f7mm10_v2_chr10_+_110745433_1107455720.748.7e-11Click!


Activity profile for motif E2f7.

activity profile for motif E2f7


Sorted Z-values histogram for motif E2f7

Sorted Z-values for motif E2f7



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f7

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_116308241 23.030 ENSMUST00000183057.1
ENSMUST00000182487.1
ENSMUST00000181998.1
Plekha7


pleckstrin homology domain containing, family A member 7


chr9_+_3013140 22.461 ENSMUST00000143083.2
Gm10721
predicted gene 10721
chr9_+_3037111 21.915 ENSMUST00000177969.1
Gm10715
predicted gene 10715
chr9_+_3025417 19.365 ENSMUST00000075573.6
Gm10717
predicted gene 10717
chr10_-_69352886 17.950 ENSMUST00000119827.1
ENSMUST00000020099.5
Cdk1

cyclin-dependent kinase 1

chr9_+_3017408 16.926 ENSMUST00000099049.3
Gm10719
predicted gene 10719
chr9_+_3015654 16.360 ENSMUST00000099050.3
Gm10720
predicted gene 10720
chr15_+_102296256 14.846 ENSMUST00000064924.4
Espl1
extra spindle poles-like 1 (S. cerevisiae)
chr2_+_72476159 14.812 ENSMUST00000102691.4
Cdca7
cell division cycle associated 7
chr12_+_24708984 13.988 ENSMUST00000154588.1
Rrm2
ribonucleotide reductase M2
chr11_+_102248842 13.634 ENSMUST00000100392.4
BC030867
cDNA sequence BC030867
chr2_+_72476225 13.605 ENSMUST00000157019.1
Cdca7
cell division cycle associated 7
chr4_+_108579445 12.052 ENSMUST00000102744.3
Orc1
origin recognition complex, subunit 1
chr12_+_24708241 11.618 ENSMUST00000020980.5
Rrm2
ribonucleotide reductase M2
chr2_-_157204483 11.170 ENSMUST00000029170.7
Rbl1
retinoblastoma-like 1 (p107)
chr13_-_100775844 11.114 ENSMUST00000075550.3
Cenph
centromere protein H
chr3_+_108383829 10.446 ENSMUST00000090561.3
ENSMUST00000102629.1
ENSMUST00000128089.1
Psrc1


proline/serine-rich coiled-coil 1


chr8_+_75109528 9.917 ENSMUST00000164309.1
Mcm5
minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
chr17_-_35516780 9.864 ENSMUST00000160885.1
ENSMUST00000159009.1
ENSMUST00000161012.1
Tcf19


transcription factor 19


chr13_+_23581563 9.459 ENSMUST00000102968.1
Hist1h4d
histone cluster 1, H4d
chr4_+_136172367 9.214 ENSMUST00000061721.5
E2f2
E2F transcription factor 2
chr7_+_110122299 8.243 ENSMUST00000033326.8
Wee1
WEE 1 homolog 1 (S. pombe)
chr6_-_88898664 8.060 ENSMUST00000058011.6
Mcm2
minichromosome maintenance deficient 2 mitotin (S. cerevisiae)
chr13_-_21783391 7.840 ENSMUST00000099704.3
Hist1h3i
histone cluster 1, H3i
chr11_-_77513335 7.837 ENSMUST00000060417.4
Trp53i13
transformation related protein 53 inducible protein 13
chr4_+_126556935 7.447 ENSMUST00000048391.8
Clspn
claspin
chr4_+_132768325 7.178 ENSMUST00000102561.4
Rpa2
replication protein A2
chr2_-_36104060 6.909 ENSMUST00000112961.3
ENSMUST00000112966.3
Lhx6

LIM homeobox protein 6

chr7_-_44548733 6.795 ENSMUST00000145956.1
ENSMUST00000049343.8
Pold1

polymerase (DNA directed), delta 1, catalytic subunit

chr6_+_15721087 6.672 ENSMUST00000120512.1
Mdfic
MyoD family inhibitor domain containing
chr11_-_6444352 6.665 ENSMUST00000093346.5
ENSMUST00000109737.2
H2afv

H2A histone family, member V

chr13_-_21833575 6.573 ENSMUST00000081342.5
Hist1h2ap
histone cluster 1, H2ap
chr10_+_3973086 6.437 ENSMUST00000117291.1
ENSMUST00000120585.1
ENSMUST00000043735.7
Mthfd1l


methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like


chr4_+_126556994 6.152 ENSMUST00000147675.1
Clspn
claspin
chr13_-_55329723 5.779 ENSMUST00000021941.7
Mxd3
Max dimerization protein 3
chrX_+_153006461 5.599 ENSMUST00000095755.3
Usp51
ubiquitin specific protease 51
chr13_+_21754067 5.326 ENSMUST00000091709.2
Hist1h2bn
histone cluster 1, H2bn
chr13_+_22035821 5.303 ENSMUST00000110455.2
Hist1h2bk
histone cluster 1, H2bk
chr14_-_20388822 5.029 ENSMUST00000022345.6
Dnajc9
DnaJ (Hsp40) homolog, subfamily C, member 9
chr6_-_67037399 5.010 ENSMUST00000043098.6
Gadd45a
growth arrest and DNA-damage-inducible 45 alpha
chr1_-_128359610 4.997 ENSMUST00000027601.4
Mcm6
minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)
chr14_+_54254124 4.983 ENSMUST00000180359.1
Abhd4
abhydrolase domain containing 4
chr13_-_22042949 4.813 ENSMUST00000091741.4
Hist1h2ag
histone cluster 1, H2ag
chr13_+_22043189 4.803 ENSMUST00000110452.1
Hist1h2bj
histone cluster 1, H2bj
chr13_+_21810428 4.732 ENSMUST00000091745.5
Hist1h2ao
histone cluster 1, H2ao
chr7_-_44816586 4.703 ENSMUST00000047356.8
Atf5
activating transcription factor 5
chr5_+_129020069 4.553 ENSMUST00000031383.7
ENSMUST00000111343.1
Ran

RAN, member RAS oncogene family

chr13_-_21716143 4.516 ENSMUST00000091756.1
Hist1h2bl
histone cluster 1, H2bl
chr12_-_11265768 4.447 ENSMUST00000166117.1
Gen1
Gen homolog 1, endonuclease (Drosophila)
chr9_+_64281575 4.446 ENSMUST00000034964.6
Tipin
timeless interacting protein
chr10_+_11281304 4.421 ENSMUST00000129456.1
Fbxo30
F-box protein 30
chr13_+_21833736 4.397 ENSMUST00000180288.1
ENSMUST00000110467.1
Hist1h2br

histone cluster 1 H2br

chr17_-_24960620 4.285 ENSMUST00000024981.7
Hn1l
hematological and neurological expressed 1-like
chr15_+_79030874 4.179 ENSMUST00000171999.1
ENSMUST00000006544.7
Gcat

glycine C-acetyltransferase (2-amino-3-ketobutyrate-coenzyme A ligase)

chr14_-_54641347 4.081 ENSMUST00000067784.6
Cdh24
cadherin-like 24
chr5_+_9100681 4.009 ENSMUST00000115365.1
Tmem243
transmembrane protein 243, mitochondrial
chr7_-_142578139 4.002 ENSMUST00000136359.1
H19
H19 fetal liver mRNA
chr10_+_91082940 3.445 ENSMUST00000020150.3
Ikbip
IKBKB interacting protein
chr13_-_21810190 3.343 ENSMUST00000110469.1
ENSMUST00000091749.2
Hist1h2bq

histone cluster 1, H2bq

chr13_-_21753851 2.966 ENSMUST00000074752.2
Hist1h2ak
histone cluster 1, H2ak
chr13_-_22035589 2.785 ENSMUST00000091742.4
Hist1h2ah
histone cluster 1, H2ah
chr1_+_180568913 2.780 ENSMUST00000027777.6
Parp1
poly (ADP-ribose) polymerase family, member 1
chr18_+_56707725 2.605 ENSMUST00000025486.8
Lmnb1
lamin B1
chr13_+_21716385 2.582 ENSMUST00000070124.3
Hist1h2ai
histone cluster 1, H2ai
chr17_+_34850373 2.518 ENSMUST00000097343.4
ENSMUST00000173357.1
ENSMUST00000173065.1
ENSMUST00000165953.2
Nelfe



negative elongation factor complex member E, Rdbp



chr11_-_101466222 2.493 ENSMUST00000040430.7
Vat1
vesicle amine transport protein 1 homolog (T californica)
chr11_-_87404380 2.363 ENSMUST00000067692.6
Rad51c
RAD51 homolog C
chr10_+_11281583 2.348 ENSMUST00000070300.4
Fbxo30
F-box protein 30
chr4_+_124714776 2.313 ENSMUST00000030734.4
Sf3a3
splicing factor 3a, subunit 3
chr19_-_41206774 2.300 ENSMUST00000025986.7
ENSMUST00000169941.1
Tll2

tolloid-like 2

chr7_+_28169744 2.297 ENSMUST00000042405.6
Fbl
fibrillarin
chr17_-_25792284 2.260 ENSMUST00000072735.7
Fam173a
family with sequence similarity 173, member A
chr13_+_23555023 2.205 ENSMUST00000045301.6
Hist1h1d
histone cluster 1, H1d
chr17_+_33524170 2.152 ENSMUST00000087623.6
Adamts10
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 10
chr12_-_73286698 2.066 ENSMUST00000116420.2
Trmt5
TRM5 tRNA methyltransferase 5
chrX_+_162760388 2.039 ENSMUST00000033720.5
ENSMUST00000112327.1
Rbbp7

retinoblastoma binding protein 7

chr12_+_112146187 2.018 ENSMUST00000128402.2
Kif26a
kinesin family member 26A
chr2_+_23321246 1.782 ENSMUST00000102945.1
Nxph2
neurexophilin 2
chr9_-_121277160 1.647 ENSMUST00000051479.6
ENSMUST00000171923.1
Ulk4

unc-51-like kinase 4

chr2_+_112261926 1.628 ENSMUST00000028553.3
Nop10
NOP10 ribonucleoprotein
chr7_+_66109474 1.618 ENSMUST00000036372.6
Chsy1
chondroitin sulfate synthase 1
chr1_-_180813591 1.599 ENSMUST00000162118.1
ENSMUST00000159685.1
ENSMUST00000161308.1
H3f3a


H3 histone, family 3A


chr10_+_91083036 1.584 ENSMUST00000020149.5
Ikbip
IKBKB interacting protein
chr16_+_38346986 1.531 ENSMUST00000050273.8
ENSMUST00000120495.1
ENSMUST00000119704.1
Cox17

Gm21987
cytochrome c oxidase assembly protein 17

predicted gene 21987
chr2_-_180920925 1.319 ENSMUST00000037299.8
ENSMUST00000108876.2
Ythdf1

YTH domain family 1

chr9_+_44334685 1.241 ENSMUST00000052686.2
H2afx
H2A histone family, member X
chr4_+_108619925 1.237 ENSMUST00000030320.6
Cc2d1b
coiled-coil and C2 domain containing 1B
chr1_+_86526688 1.198 ENSMUST00000045897.8
Ptma
prothymosin alpha
chr9_-_87255536 1.000 ENSMUST00000093802.4
4922501C03Rik
RIKEN cDNA 4922501C03 gene
chr17_+_35517100 0.996 ENSMUST00000164242.2
ENSMUST00000045956.7
Cchcr1

coiled-coil alpha-helical rod protein 1

chr12_+_73286868 0.988 ENSMUST00000153941.1
ENSMUST00000122920.1
ENSMUST00000101313.3
Slc38a6


solute carrier family 38, member 6


chr1_+_172521044 0.949 ENSMUST00000085894.5
ENSMUST00000161140.1
ENSMUST00000162988.1
Ccdc19


coiled-coil domain containing 19


chr2_+_130667610 0.918 ENSMUST00000103193.4
Itpa
inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
chr1_-_135167606 0.877 ENSMUST00000027682.8
Gpr37l1
G protein-coupled receptor 37-like 1
chr13_+_23574381 0.877 ENSMUST00000090776.4
Hist1h2ad
histone cluster 1, H2ad
chr10_-_35711891 0.862 ENSMUST00000080898.2
Amd2
S-adenosylmethionine decarboxylase 2
chr17_+_28691342 0.855 ENSMUST00000114758.1
ENSMUST00000004990.6
ENSMUST00000062694.8
ENSMUST00000114754.1
Mapk14



mitogen-activated protein kinase 14



chr19_-_10881723 0.763 ENSMUST00000144681.1
Tmem109
transmembrane protein 109
chr7_+_35802593 0.754 ENSMUST00000052454.2
E130304I02Rik
RIKEN cDNA E130304I02 gene
chr11_-_61762040 0.751 ENSMUST00000004955.7
ENSMUST00000168115.1
Prpsap2

phosphoribosyl pyrophosphate synthetase-associated protein 2

chr11_+_88047693 0.719 ENSMUST00000079866.4
Srsf1
serine/arginine-rich splicing factor 1
chrX_-_37085402 0.712 ENSMUST00000115231.3
Rpl39
ribosomal protein L39
chr3_+_60501252 0.708 ENSMUST00000099087.2
Mbnl1
muscleblind-like 1 (Drosophila)
chr13_-_23574196 0.687 ENSMUST00000105106.1
Hist1h2bf
histone cluster 1, H2bf
chr7_-_28598140 0.649 ENSMUST00000108283.1
ENSMUST00000040531.8
Pak4
Samd4b
p21 protein (Cdc42/Rac)-activated kinase 4
sterile alpha motif domain containing 4B
chr5_+_129941949 0.646 ENSMUST00000051758.7
ENSMUST00000073945.4
Vkorc1l1

vitamin K epoxide reductase complex, subunit 1-like 1

chr2_+_18672384 0.569 ENSMUST00000171845.1
ENSMUST00000061158.4
Commd3

COMM domain containing 3

chr14_-_54253907 0.554 ENSMUST00000128231.1
Dad1
defender against cell death 1
chr3_+_152396664 0.497 ENSMUST00000089982.4
ENSMUST00000106101.1
Zzz3

zinc finger, ZZ domain containing 3

chr7_+_44816088 0.469 ENSMUST00000057195.9
ENSMUST00000107891.1
Nup62

nucleoporin 62

chr10_-_117376922 0.357 ENSMUST00000177145.1
ENSMUST00000176670.1
Cpsf6

cleavage and polyadenylation specific factor 6

chr15_-_81871883 0.313 ENSMUST00000023117.8
Phf5a
PHD finger protein 5A
chr5_+_43662373 0.292 ENSMUST00000048150.8
Cc2d2a
coiled-coil and C2 domain containing 2A
chr3_-_57847478 0.283 ENSMUST00000120289.1
ENSMUST00000066882.8
Pfn2

profilin 2

chr1_+_74506044 0.177 ENSMUST00000087215.5
Rqcd1
rcd1 (required for cell differentiation) homolog 1 (S. pombe)
chr19_-_10881677 0.073 ENSMUST00000128835.1
Tmem109
transmembrane protein 109
chr1_-_156474249 0.046 ENSMUST00000051396.6
Soat1
sterol O-acyltransferase 1
chr9_+_44084944 0.019 ENSMUST00000176416.1
ENSMUST00000065461.7
Usp2

ubiquitin specific peptidase 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.8 23.0 GO:0045218 zonula adherens maintenance(GO:0045218)
3.0 12.1 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
2.3 6.8 GO:0045004 DNA replication proofreading(GO:0045004)
1.7 15.2 GO:0090166 Golgi disassembly(GO:0090166)
1.4 25.6 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
1.4 13.6 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
1.3 9.2 GO:1990086 lens fiber cell apoptotic process(GO:1990086)
1.3 13.1 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
1.3 6.4 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
1.2 6.9 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
1.1 14.8 GO:0000212 meiotic spindle organization(GO:0000212)
0.9 11.2 GO:0002227 innate immune response in mucosa(GO:0002227)
0.9 2.8 GO:1904760 myofibroblast differentiation(GO:0036446) regulation of myofibroblast differentiation(GO:1904760)
0.9 4.4 GO:0000076 DNA replication checkpoint(GO:0000076)
0.9 2.6 GO:0031660 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662)
0.6 2.4 GO:0007066 female meiosis sister chromatid cohesion(GO:0007066)
0.6 4.6 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.6 17.3 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.6 8.9 GO:0051382 kinetochore assembly(GO:0051382)
0.5 2.1 GO:1900864 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.5 1.5 GO:1904959 regulation of electron carrier activity(GO:1904732) regulation of cytochrome-c oxidase activity(GO:1904959)
0.5 2.5 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
0.5 4.4 GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
0.5 2.3 GO:0048631 regulation of skeletal muscle tissue growth(GO:0048631)
0.5 2.3 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
0.4 1.6 GO:1902340 telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340)
0.4 5.0 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.4 4.0 GO:2000653 regulation of genetic imprinting(GO:2000653)
0.4 9.9 GO:0006270 DNA replication initiation(GO:0006270)
0.3 10.9 GO:0090224 regulation of mitotic spindle organization(GO:0060236) regulation of spindle organization(GO:0090224)
0.3 9.9 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.3 7.2 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.3 1.6 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
0.3 2.2 GO:0016584 nucleosome positioning(GO:0016584)
0.3 0.9 GO:0006597 spermine biosynthetic process(GO:0006597)
0.3 0.9 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835)
0.3 2.5 GO:1900364 negative regulation of mRNA polyadenylation(GO:1900364)
0.3 6.7 GO:0050434 positive regulation of viral transcription(GO:0050434)
0.3 5.6 GO:0021924 cell proliferation in external granule layer(GO:0021924) cerebellar granule cell precursor proliferation(GO:0021930)
0.3 26.7 GO:0006342 chromatin silencing(GO:0006342)
0.2 10.1 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.2 0.6 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.2 5.6 GO:0016578 histone deubiquitination(GO:0016578)
0.2 1.6 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.2 2.0 GO:0048484 enteric nervous system development(GO:0048484)
0.1 1.2 GO:0043486 histone exchange(GO:0043486)
0.1 0.9 GO:0009146 purine nucleoside triphosphate catabolic process(GO:0009146)
0.1 5.3 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.1 1.9 GO:0044458 motile cilium assembly(GO:0044458)
0.1 1.3 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.1 4.2 GO:0006334 nucleosome assembly(GO:0006334)
0.0 2.0 GO:0034605 cellular response to heat(GO:0034605)
0.0 5.1 GO:0030010 establishment of cell polarity(GO:0030010)
0.0 1.0 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.8 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.0 0.6 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.7 GO:0045445 myoblast differentiation(GO:0045445)
0.0 1.0 GO:0006611 protein export from nucleus(GO:0006611)
0.0 3.8 GO:0016042 lipid catabolic process(GO:0016042)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
5.1 25.6 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
2.5 20.1 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
2.3 6.8 GO:0043625 delta DNA polymerase complex(GO:0043625)
2.1 23.0 GO:0005915 zonula adherens(GO:0005915)
1.5 4.6 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.8 11.8 GO:0042555 MCM complex(GO:0042555)
0.8 2.3 GO:0001651 dense fibrillar component(GO:0001651)
0.6 4.4 GO:0031298 replication fork protection complex(GO:0031298)
0.6 2.5 GO:0032021 NELF complex(GO:0032021)
0.6 18.9 GO:0000788 nuclear nucleosome(GO:0000788)
0.6 21.2 GO:0000786 nucleosome(GO:0000786)
0.5 7.2 GO:0005662 DNA replication factor A complex(GO:0005662)
0.5 2.4 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063) Holliday junction resolvase complex(GO:0048476)
0.4 25.2 GO:0005876 spindle microtubule(GO:0005876)
0.4 1.6 GO:0090661 box H/ACA telomerase RNP complex(GO:0090661)
0.4 2.6 GO:0005638 lamin filament(GO:0005638)
0.2 0.8 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.2 15.3 GO:0072686 mitotic spindle(GO:0072686)
0.2 2.2 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.1 1.6 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 10.6 GO:0000790 nuclear chromatin(GO:0000790)
0.1 15.0 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 2.0 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 8.9 GO:0000776 kinetochore(GO:0000776)
0.0 13.5 GO:0005667 transcription factor complex(GO:0005667)
0.0 2.0 GO:0005871 kinesin complex(GO:0005871)
0.0 2.5 GO:0005844 polysome(GO:0005844)
0.0 0.6 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 1.5 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.3 GO:0036038 MKS complex(GO:0036038)
0.0 0.3 GO:0005686 U2 snRNP(GO:0005686)
0.0 1.0 GO:0005814 centriole(GO:0005814)
0.0 0.9 GO:0000922 spindle pole(GO:0000922)
0.0 2.5 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 32.4 GO:0005654 nucleoplasm(GO:0005654)
0.0 0.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.8 GO:0016529 sarcoplasmic reticulum(GO:0016529)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
5.1 25.6 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
2.3 13.6 GO:0010997 anaphase-promoting complex binding(GO:0010997)
2.3 27.1 GO:0070097 delta-catenin binding(GO:0070097)
1.6 6.4 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
1.6 8.0 GO:0043515 kinetochore binding(GO:0043515)
1.3 18.0 GO:0003688 DNA replication origin binding(GO:0003688)
1.2 17.5 GO:0035173 histone kinase activity(GO:0035173)
0.9 6.8 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.8 4.6 GO:0070883 pre-miRNA binding(GO:0070883)
0.8 6.8 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.5 1.6 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.5 6.4 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.5 2.8 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.4 6.7 GO:0030957 Tat protein binding(GO:0030957)
0.3 11.2 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.3 2.3 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.3 2.1 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.2 1.6 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.2 0.9 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.2 9.4 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.2 0.9 GO:0019808 polyamine binding(GO:0019808)
0.2 1.5 GO:0016531 copper chaperone activity(GO:0016531)
0.2 1.3 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.2 0.8 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.2 0.7 GO:0001069 regulatory region RNA binding(GO:0001069)
0.2 8.2 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 11.0 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 0.9 GO:0051525 NFAT protein binding(GO:0051525)
0.1 5.0 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 2.6 GO:0008432 JUN kinase binding(GO:0008432) phospholipase binding(GO:0043274)
0.1 0.5 GO:0051425 PTB domain binding(GO:0051425)
0.1 14.1 GO:0042393 histone binding(GO:0042393)
0.1 13.5 GO:0001047 core promoter binding(GO:0001047)
0.1 9.7 GO:0031072 heat shock protein binding(GO:0031072)
0.1 4.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.6 GO:0048038 quinone binding(GO:0048038)
0.0 2.2 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 0.6 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.6 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 8.2 GO:0008017 microtubule binding(GO:0008017)
0.0 49.1 GO:0003677 DNA binding(GO:0003677)
0.0 6.0 GO:0061659 ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0 0.9 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 26.2 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.8 9.2 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.7 33.3 PID_ATR_PATHWAY ATR signaling pathway
0.6 48.8 PID_E2F_PATHWAY E2F transcription factor network
0.4 23.0 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.3 4.6 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.2 25.1 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.2 4.7 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.1 5.0 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 2.8 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 6.7 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 2.6 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 1.2 PID_ATM_PATHWAY ATM pathway
0.0 0.9 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.0 2.0 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 4.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.9 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 30.0 REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
1.8 9.2 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
1.8 25.6 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
1.8 23.0 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
1.6 14.0 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
1.0 8.2 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.9 32.2 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.7 11.2 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.5 13.2 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.4 9.4 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.2 4.6 REACTOME_MICRORNA_MIRNA_BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.1 2.2 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 1.6 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 2.8 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 4.2 REACTOME_MEIOSIS Genes involved in Meiosis
0.1 2.0 REACTOME_KINESINS Genes involved in Kinesins
0.1 0.9 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.0 0.6 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 2.3 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 1.5 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.3 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.5 REACTOME_TRANSPORT_OF_RIBONUCLEOPROTEINS_INTO_THE_HOST_NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus