Motif ID: E2f7

Z-value: 1.621


Transcription factors associated with E2f7:

Gene SymbolEntrez IDGene Name
E2f7 ENSMUSG00000020185.10 E2f7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f7mm10_v2_chr10_+_110745433_1107455720.748.7e-11Click!


Activity profile for motif E2f7.

activity profile for motif E2f7


Sorted Z-values histogram for motif E2f7

Sorted Z-values for motif E2f7



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f7

PNG image of the network

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Top targets:


Showing 1 to 20 of 118 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_116308241 23.030 ENSMUST00000183057.1
ENSMUST00000182487.1
ENSMUST00000181998.1
 Plekha7


pleckstrin homology domain containing, family A member 7


chr9_+_3013140 22.461 ENSMUST00000143083.2
 Gm10721
predicted gene 10721
chr9_+_3037111 21.915 ENSMUST00000177969.1
 Gm10715
predicted gene 10715
chr9_+_3025417 19.365 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr10_-_69352886 17.950 ENSMUST00000119827.1
ENSMUST00000020099.5
 Cdk1

cyclin-dependent kinase 1

chr9_+_3017408 16.926 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr9_+_3015654 16.360 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr15_+_102296256 14.846 ENSMUST00000064924.4
 Espl1
extra spindle poles-like 1 (S. cerevisiae)
chr2_+_72476159 14.812 ENSMUST00000102691.4
 Cdca7
cell division cycle associated 7
chr12_+_24708984 13.988 ENSMUST00000154588.1
 Rrm2
ribonucleotide reductase M2
chr11_+_102248842 13.634 ENSMUST00000100392.4
 BC030867
cDNA sequence BC030867
chr2_+_72476225 13.605 ENSMUST00000157019.1
 Cdca7
cell division cycle associated 7
chr4_+_108579445 12.052 ENSMUST00000102744.3
 Orc1
origin recognition complex, subunit 1
chr12_+_24708241 11.618 ENSMUST00000020980.5
 Rrm2
ribonucleotide reductase M2
chr2_-_157204483 11.170 ENSMUST00000029170.7
 Rbl1
retinoblastoma-like 1 (p107)
chr13_-_100775844 11.114 ENSMUST00000075550.3
 Cenph
centromere protein H
chr3_+_108383829 10.446 ENSMUST00000090561.3
ENSMUST00000102629.1
ENSMUST00000128089.1
 Psrc1


proline/serine-rich coiled-coil 1


chr8_+_75109528 9.917 ENSMUST00000164309.1
 Mcm5
minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
chr17_-_35516780 9.864 ENSMUST00000160885.1
ENSMUST00000159009.1
ENSMUST00000161012.1
 Tcf19


transcription factor 19


chr13_+_23581563 9.459 ENSMUST00000102968.1
 Hist1h4d
histone cluster 1, H4d

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 26.7 GO:0006342 chromatin silencing(GO:0006342)
1.4 25.6 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
3.8 23.0 GO:0045218 zonula adherens maintenance(GO:0045218)
0.6 17.3 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
1.7 15.2 GO:0090166 Golgi disassembly(GO:0090166)
1.1 14.8 GO:0000212 meiotic spindle organization(GO:0000212)
1.4 13.6 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
1.3 13.1 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
3.0 12.1 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.9 11.2 GO:0002227 innate immune response in mucosa(GO:0002227)
0.3 10.9 GO:0090224 regulation of mitotic spindle organization(GO:0060236) regulation of spindle organization(GO:0090224)
0.2 10.1 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.4 9.9 GO:0006270 DNA replication initiation(GO:0006270)
0.3 9.9 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
1.3 9.2 GO:1990086 lens fiber cell apoptotic process(GO:1990086)
0.6 8.9 GO:0051382 kinetochore assembly(GO:0051382)
0.3 7.2 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
1.2 6.9 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
2.3 6.8 GO:0045004 DNA replication proofreading(GO:0045004)
0.3 6.7 GO:0050434 positive regulation of viral transcription(GO:0050434)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 32.4 GO:0005654 nucleoplasm(GO:0005654)
5.1 25.6 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.4 25.2 GO:0005876 spindle microtubule(GO:0005876)
2.1 23.0 GO:0005915 zonula adherens(GO:0005915)
0.6 21.2 GO:0000786 nucleosome(GO:0000786)
2.5 20.1 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.6 18.9 GO:0000788 nuclear nucleosome(GO:0000788)
0.2 15.3 GO:0072686 mitotic spindle(GO:0072686)
0.1 15.0 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 13.5 GO:0005667 transcription factor complex(GO:0005667)
0.8 11.8 GO:0042555 MCM complex(GO:0042555)
0.1 10.6 GO:0000790 nuclear chromatin(GO:0000790)
0.1 8.9 GO:0000776 kinetochore(GO:0000776)
0.5 7.2 GO:0005662 DNA replication factor A complex(GO:0005662)
2.3 6.8 GO:0043625 delta DNA polymerase complex(GO:0043625)
1.5 4.6 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.6 4.4 GO:0031298 replication fork protection complex(GO:0031298)
0.4 2.6 GO:0005638 lamin filament(GO:0005638)
0.6 2.5 GO:0032021 NELF complex(GO:0032021)
0.0 2.5 GO:0005844 polysome(GO:0005844)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 49.1 GO:0003677 DNA binding(GO:0003677)
2.3 27.1 GO:0070097 delta-catenin binding(GO:0070097)
5.1 25.6 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
1.3 18.0 GO:0003688 DNA replication origin binding(GO:0003688)
1.2 17.5 GO:0035173 histone kinase activity(GO:0035173)
0.1 14.1 GO:0042393 histone binding(GO:0042393)
2.3 13.6 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.1 13.5 GO:0001047 core promoter binding(GO:0001047)
0.3 11.2 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 11.0 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 9.7 GO:0031072 heat shock protein binding(GO:0031072)
0.2 9.4 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.2 8.2 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 8.2 GO:0008017 microtubule binding(GO:0008017)
1.6 8.0 GO:0043515 kinetochore binding(GO:0043515)
0.9 6.8 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.8 6.8 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.4 6.7 GO:0030957 Tat protein binding(GO:0030957)
1.6 6.4 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.5 6.4 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)

Gene overrepresentation in C2:CP category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 48.8 PID_E2F_PATHWAY E2F transcription factor network
0.7 33.3 PID_ATR_PATHWAY ATR signaling pathway
2.9 26.2 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2 25.1 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.4 23.0 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.8 9.2 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 6.7 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 5.0 PID_AURORA_A_PATHWAY Aurora A signaling
0.2 4.7 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.3 4.6 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 4.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.8 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 2.6 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 2.0 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.1 1.2 PID_ATM_PATHWAY ATM pathway
0.0 0.9 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.0 0.9 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 32.2 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
3.0 30.0 REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
1.8 25.6 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
1.8 23.0 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
1.6 14.0 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.5 13.2 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.7 11.2 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.4 9.4 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
1.8 9.2 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
1.0 8.2 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.2 4.6 REACTOME_MICRORNA_MIRNA_BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.1 4.2 REACTOME_MEIOSIS Genes involved in Meiosis
0.1 2.8 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 2.3 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 2.2 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 2.0 REACTOME_KINESINS Genes involved in Kinesins
0.1 1.6 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 1.5 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.1 0.9 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.0 0.6 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac