Motif ID: E2f8

Z-value: 1.737


Transcription factors associated with E2f8:

Gene SymbolEntrez IDGene Name
E2f8 ENSMUSG00000046179.11 E2f8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f8mm10_v2_chr7_-_48881596_488816190.933.5e-24Click!


Activity profile for motif E2f8.

activity profile for motif E2f8


Sorted Z-values histogram for motif E2f8

Sorted Z-values for motif E2f8



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f8

PNG image of the network

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Top targets:


Showing 1 to 20 of 83 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_56303321 20.684 ENSMUST00000001258.8
 Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr11_-_89302545 19.627 ENSMUST00000061728.3
 Nog
noggin
chr8_+_75109528 19.130 ENSMUST00000164309.1
 Mcm5
minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
chr7_-_115824699 18.455 ENSMUST00000169129.1
 Sox6
SRY-box containing gene 6
chr17_+_56303396 18.279 ENSMUST00000113038.1
 Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr5_+_123749696 17.202 ENSMUST00000031366.7
 Kntc1
kinetochore associated 1
chr9_-_36726374 17.193 ENSMUST00000172702.2
ENSMUST00000172742.1
ENSMUST00000034625.5
 Chek1


checkpoint kinase 1


chr17_+_56040350 16.631 ENSMUST00000002914.8
 Chaf1a
chromatin assembly factor 1, subunit A (p150)
chr12_+_24708984 16.324 ENSMUST00000154588.1
 Rrm2
ribonucleotide reductase M2
chr7_-_48881032 14.915 ENSMUST00000058745.8
 E2f8
E2F transcription factor 8
chr11_+_98907801 14.889 ENSMUST00000092706.6
 Cdc6
cell division cycle 6
chr6_-_88898664 14.840 ENSMUST00000058011.6
 Mcm2
minichromosome maintenance deficient 2 mitotin (S. cerevisiae)
chr16_-_18811615 13.539 ENSMUST00000096990.3
 Cdc45
cell division cycle 45
chr2_-_34913976 13.513 ENSMUST00000028232.3
 Phf19
PHD finger protein 19
chr7_-_48881596 13.372 ENSMUST00000119223.1
 E2f8
E2F transcription factor 8
chr12_+_24708241 13.193 ENSMUST00000020980.5
 Rrm2
ribonucleotide reductase M2
chr2_+_163054682 13.060 ENSMUST00000018005.3
 Mybl2
myeloblastosis oncogene-like 2
chr7_+_110122299 12.471 ENSMUST00000033326.8
 Wee1
WEE 1 homolog 1 (S. pombe)
chr1_-_128359610 12.158 ENSMUST00000027601.4
 Mcm6
minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)
chr8_+_40926220 12.157 ENSMUST00000034004.9
 Pdgfrl
platelet-derived growth factor receptor-like

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.0 59.7 GO:0010216 maintenance of DNA methylation(GO:0010216)
1.5 38.6 GO:0006270 DNA replication initiation(GO:0006270)
3.3 33.0 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
1.6 29.5 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
9.4 28.3 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
2.1 20.7 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
4.9 19.6 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
1.7 18.5 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.5 16.6 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.1 16.1 GO:0007093 mitotic cell cycle checkpoint(GO:0007093)
4.5 13.5 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) DNA replication preinitiation complex assembly(GO:0071163) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
1.9 13.5 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.2 13.1 GO:0090307 mitotic spindle assembly(GO:0090307)
0.1 11.6 GO:0030010 establishment of cell polarity(GO:0030010)
3.6 10.8 GO:0032474 otolith morphogenesis(GO:0032474)
1.3 10.4 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.8 10.4 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.0 10.1 GO:0006897 endocytosis(GO:0006897)
1.9 9.4 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
3.1 9.2 GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 65.0 GO:0005657 replication fork(GO:0005657)
0.1 52.2 GO:0005667 transcription factor complex(GO:0005667)
3.3 49.6 GO:0042555 MCM complex(GO:0042555)
5.9 29.5 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.8 20.7 GO:0005721 pericentric heterochromatin(GO:0005721)
5.7 17.2 GO:1990423 RZZ complex(GO:1990423)
0.8 16.8 GO:0035098 ESC/E(Z) complex(GO:0035098)
5.5 16.6 GO:0033186 CAF-1 complex(GO:0033186)
4.5 13.5 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
2.6 13.1 GO:0031523 Myb complex(GO:0031523)
0.4 12.1 GO:0051233 spindle midzone(GO:0051233)
0.0 11.2 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
1.5 10.4 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.1 9.4 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
1.8 9.2 GO:0035189 Rb-E2F complex(GO:0035189)
3.0 8.9 GO:0043625 delta DNA polymerase complex(GO:0043625)
1.5 8.9 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 8.9 GO:0030424 axon(GO:0030424)
0.7 8.2 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
1.5 7.4 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.4 47.5 GO:0003688 DNA replication origin binding(GO:0003688)
0.2 46.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
9.7 39.0 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
5.9 29.5 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
2.8 22.4 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.2 20.7 GO:0004386 helicase activity(GO:0004386)
0.5 18.1 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
5.7 17.2 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
2.1 16.6 GO:0070087 chromo shadow domain binding(GO:0070087)
0.4 13.6 GO:0017025 TBP-class protein binding(GO:0017025)
0.2 12.5 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.3 11.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.2 11.4 GO:0019955 cytokine binding(GO:0019955)
0.2 10.5 GO:0035064 methylated histone binding(GO:0035064)
3.5 10.4 GO:0071207 histone pre-mRNA stem-loop binding(GO:0071207)
1.0 8.9 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.8 8.9 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.7 8.8 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.0 8.2 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 7.6 GO:0048306 calcium-dependent protein binding(GO:0048306)

Gene overrepresentation in C2:CP category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 44.5 PID_E2F_PATHWAY E2F transcription factor network
0.9 43.1 PID_ATR_PATHWAY ATR signaling pathway
3.3 29.7 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.5 20.7 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.3 16.8 PID_BMP_PATHWAY BMP receptor signaling
0.4 14.2 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.2 10.8 PID_ERBB4_PATHWAY ErbB4 signaling events
0.2 10.7 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.2 9.3 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.8 9.2 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2 8.9 PID_FAS_PATHWAY FAS (CD95) signaling pathway
0.3 8.2 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.1 6.9 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 6.0 PID_CMYB_PATHWAY C-MYB transcription factor network
0.2 5.6 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 5.6 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.3 5.0 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.4 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.1 65.6 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
3.0 53.7 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
3.3 29.7 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
1.2 20.6 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.7 19.6 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
2.0 17.7 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.4 14.2 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 10.8 REACTOME_SIGNALING_BY_EGFR_IN_CANCER Genes involved in Signaling by EGFR in Cancer
0.9 10.4 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.1 9.3 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.4 8.2 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
1.9 7.4 REACTOME_PROCESSIVE_SYNTHESIS_ON_THE_LAGGING_STRAND Genes involved in Processive synthesis on the lagging strand
0.2 5.0 REACTOME_MICRORNA_MIRNA_BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.0 4.7 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.4 3.9 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 3.8 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.0 1.5 REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE Genes involved in Late Phase of HIV Life Cycle
0.1 1.0 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.6 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.6 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins