Motif ID: E2f8

Z-value: 1.737


Transcription factors associated with E2f8:

Gene SymbolEntrez IDGene Name
E2f8 ENSMUSG00000046179.11 E2f8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f8mm10_v2_chr7_-_48881596_488816190.933.5e-24Click!


Activity profile for motif E2f8.

activity profile for motif E2f8


Sorted Z-values histogram for motif E2f8

Sorted Z-values for motif E2f8



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f8

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_56303321 20.684 ENSMUST00000001258.8
 Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr11_-_89302545 19.627 ENSMUST00000061728.3
 Nog
noggin
chr8_+_75109528 19.130 ENSMUST00000164309.1
 Mcm5
minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
chr7_-_115824699 18.455 ENSMUST00000169129.1
 Sox6
SRY-box containing gene 6
chr17_+_56303396 18.279 ENSMUST00000113038.1
 Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr5_+_123749696 17.202 ENSMUST00000031366.7
 Kntc1
kinetochore associated 1
chr9_-_36726374 17.193 ENSMUST00000172702.2
ENSMUST00000172742.1
ENSMUST00000034625.5
 Chek1


checkpoint kinase 1


chr17_+_56040350 16.631 ENSMUST00000002914.8
 Chaf1a
chromatin assembly factor 1, subunit A (p150)
chr12_+_24708984 16.324 ENSMUST00000154588.1
 Rrm2
ribonucleotide reductase M2
chr7_-_48881032 14.915 ENSMUST00000058745.8
 E2f8
E2F transcription factor 8
chr11_+_98907801 14.889 ENSMUST00000092706.6
 Cdc6
cell division cycle 6
chr6_-_88898664 14.840 ENSMUST00000058011.6
 Mcm2
minichromosome maintenance deficient 2 mitotin (S. cerevisiae)
chr16_-_18811615 13.539 ENSMUST00000096990.3
 Cdc45
cell division cycle 45
chr2_-_34913976 13.513 ENSMUST00000028232.3
 Phf19
PHD finger protein 19
chr7_-_48881596 13.372 ENSMUST00000119223.1
 E2f8
E2F transcription factor 8
chr12_+_24708241 13.193 ENSMUST00000020980.5
 Rrm2
ribonucleotide reductase M2
chr2_+_163054682 13.060 ENSMUST00000018005.3
 Mybl2
myeloblastosis oncogene-like 2
chr7_+_110122299 12.471 ENSMUST00000033326.8
 Wee1
WEE 1 homolog 1 (S. pombe)
chr1_-_128359610 12.158 ENSMUST00000027601.4
 Mcm6
minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)
chr8_+_40926220 12.157 ENSMUST00000034004.9
 Pdgfrl
platelet-derived growth factor receptor-like
chr6_-_94700137 10.798 ENSMUST00000101126.2
ENSMUST00000032105.4
 Lrig1

leucine-rich repeats and immunoglobulin-like domains 1

chr2_+_145785980 10.745 ENSMUST00000110005.1
ENSMUST00000094480.4
 Rin2

Ras and Rab interactor 2

chr19_+_38931008 10.739 ENSMUST00000145051.1
 Hells
helicase, lymphoid specific
chr19_+_38930909 9.970 ENSMUST00000025965.5
 Hells
helicase, lymphoid specific
chr10_-_21160925 9.297 ENSMUST00000020158.6
 Myb
myeloblastosis oncogene
chr2_-_157204483 9.209 ENSMUST00000029170.7
 Rbl1
retinoblastoma-like 1 (p107)
chr7_-_44548733 8.943 ENSMUST00000145956.1
ENSMUST00000049343.8
 Pold1

polymerase (DNA directed), delta 1, catalytic subunit

chr4_+_132768325 8.786 ENSMUST00000102561.4
 Rpa2
replication protein A2
chr11_+_26387194 8.151 ENSMUST00000109509.1
ENSMUST00000136830.1
 Fancl

Fanconi anemia, complementation group L

chr10_+_128015157 7.401 ENSMUST00000178041.1
ENSMUST00000026461.7
 Prim1

DNA primase, p49 subunit

chr16_-_46496955 7.168 ENSMUST00000023335.6
ENSMUST00000023334.8
 Pvrl3

poliovirus receptor-related 3

chr16_-_46496772 7.051 ENSMUST00000149901.1
ENSMUST00000096052.2
 Pvrl3

poliovirus receptor-related 3

chr6_+_117917281 7.040 ENSMUST00000180020.1
ENSMUST00000177570.1
 Hnrnpf

heterogeneous nuclear ribonucleoprotein F

chr13_+_19623163 6.899 ENSMUST00000002883.5
 Sfrp4
secreted frizzled-related protein 4
chr5_-_33652296 6.845 ENSMUST00000151081.1
ENSMUST00000101354.3
 Slbp

stem-loop binding protein

chr16_+_10835046 6.722 ENSMUST00000037913.8
 Rmi2
RMI2, RecQ mediated genome instability 2, homolog (S. cerevisiae)
chr6_+_117916981 6.524 ENSMUST00000179478.1
 Hnrnpf
heterogeneous nuclear ribonucleoprotein F
chr16_-_15637277 5.963 ENSMUST00000023353.3
 Mcm4
minichromosome maintenance deficient 4 homolog (S. cerevisiae)
chr2_-_84743655 5.948 ENSMUST00000181711.1
 Gm19426
predicted gene, 19426
chr15_+_55557399 5.751 ENSMUST00000022998.7
 Mtbp
Mdm2, transformed 3T3 cell double minute p53 binding protein
chr15_+_78926720 5.612 ENSMUST00000089377.5
 Lgals1
lectin, galactose binding, soluble 1
chr7_-_27337667 5.592 ENSMUST00000038618.6
ENSMUST00000108369.2
 Ltbp4

latent transforming growth factor beta binding protein 4

chr5_+_129020069 4.995 ENSMUST00000031383.7
ENSMUST00000111343.1
 Ran

RAN, member RAS oncogene family

chr2_+_23321246 4.914 ENSMUST00000102945.1
 Nxph2
neurexophilin 2
chr2_-_154569720 4.801 ENSMUST00000000894.5
 E2f1
E2F transcription factor 1
chr5_-_65335597 4.783 ENSMUST00000172660.1
ENSMUST00000172732.1
ENSMUST00000031092.8
 Rfc1


replication factor C (activator 1) 1


chr11_-_101785252 4.715 ENSMUST00000164750.1
ENSMUST00000107176.1
ENSMUST00000017868.6
 Etv4


ets variant gene 4 (E1A enhancer binding protein, E1AF)


chr9_+_103305156 4.550 ENSMUST00000035164.3
 Topbp1
topoisomerase (DNA) II binding protein 1
chr2_-_154569845 4.445 ENSMUST00000103145.4
 E2f1
E2F transcription factor 1
chr5_-_65335564 4.105 ENSMUST00000172780.1
 Rfc1
replication factor C (activator 1) 1
chr12_+_110279228 3.882 ENSMUST00000097228.4
 Dio3
deiodinase, iodothyronine type III
chr5_+_111581422 3.683 ENSMUST00000064930.3
 C130026L21Rik
RIKEN cDNA C130026L21 gene
chr15_+_55557575 3.634 ENSMUST00000170046.1
 Mtbp
Mdm2, transformed 3T3 cell double minute p53 binding protein
chr5_-_33652339 3.540 ENSMUST00000075670.6
 Slbp
stem-loop binding protein
chr7_+_102065713 3.492 ENSMUST00000094129.2
ENSMUST00000094130.2
ENSMUST00000084843.3
 Trpc2


transient receptor potential cation channel, subfamily C, member 2


chr16_-_18248697 3.463 ENSMUST00000115645.3
 Ranbp1
RAN binding protein 1
chr5_+_137787769 3.177 ENSMUST00000035852.7
 Zcwpw1
zinc finger, CW type with PWWP domain 1
chr4_-_129189646 2.948 ENSMUST00000106059.1
 S100pbp
S100P binding protein
chr1_+_131910458 2.814 ENSMUST00000062264.6
 Nucks1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr10_+_42860348 2.790 ENSMUST00000063063.7
 Scml4
sex comb on midleg-like 4 (Drosophila)
chr5_+_150673739 2.502 ENSMUST00000016569.4
ENSMUST00000038900.8
 Pds5b

PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)

chr4_-_129189512 2.475 ENSMUST00000117965.1
ENSMUST00000106061.2
ENSMUST00000072431.6
 S100pbp


S100P binding protein


chr11_+_79993062 2.180 ENSMUST00000017692.8
ENSMUST00000163272.1
 Suz12

suppressor of zeste 12 homolog (Drosophila)

chr4_-_129189600 2.167 ENSMUST00000117497.1
ENSMUST00000117350.1
 S100pbp

S100P binding protein

chr13_+_94875600 1.787 ENSMUST00000022195.10
 Otp
orthopedia homolog (Drosophila)
chr2_-_18048784 1.739 ENSMUST00000142856.1
 Skida1
SKI/DACH domain containing 1
chr7_+_102065485 1.621 ENSMUST00000106950.1
ENSMUST00000146450.1
 Trpc2

transient receptor potential cation channel, subfamily C, member 2

chr18_-_9726670 1.272 ENSMUST00000171339.1
 Gm17430
predicted gene, 17430
chr11_+_77462325 1.250 ENSMUST00000102493.1
 Coro6
coronin 6
chr11_+_88047693 1.209 ENSMUST00000079866.4
 Srsf1
serine/arginine-rich splicing factor 1
chr13_+_44731265 1.151 ENSMUST00000173246.1
 Jarid2
jumonji, AT rich interactive domain 2
chr3_-_127553233 1.124 ENSMUST00000029588.5
 Larp7
La ribonucleoprotein domain family, member 7
chr6_+_38551786 0.958 ENSMUST00000161227.1
 Luc7l2
LUC7-like 2 (S. cerevisiae)
chrX_+_73716577 0.924 ENSMUST00000002084.7
 Abcd1
ATP-binding cassette, sub-family D (ALD), member 1
chr9_-_50659780 0.645 ENSMUST00000034567.3
 Dlat
dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)
chrX_-_73716145 0.612 ENSMUST00000002091.5
 Bcap31
B cell receptor associated protein 31
chr17_-_35235755 0.433 ENSMUST00000048994.6
 Nfkbil1
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor like 1
chr1_+_42229726 0.383 ENSMUST00000066196.1
 Gm9915
predicted gene 9915
chr15_-_55557748 0.156 ENSMUST00000172387.1
 Mrpl13
mitochondrial ribosomal protein L13
chrX_+_73716712 0.125 ENSMUST00000114461.2
 Abcd1
ATP-binding cassette, sub-family D (ALD), member 1
chrX_-_70477170 0.116 ENSMUST00000101506.3
ENSMUST00000114630.2
 BC023829

cDNA sequence BC023829

chr5_+_135187251 0.060 ENSMUST00000002825.5
 Baz1b
bromodomain adjacent to zinc finger domain, 1B
chr10_+_19356558 0.013 ENSMUST00000053225.5
 Olig3
oligodendrocyte transcription factor 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
9.4 28.3 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
4.9 19.6 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
4.5 13.5 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) DNA replication preinitiation complex assembly(GO:0071163) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
4.0 59.7 GO:0010216 maintenance of DNA methylation(GO:0010216)
3.6 10.8 GO:0032474 otolith morphogenesis(GO:0032474)
3.3 33.0 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
3.1 9.2 GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
3.0 8.9 GO:0045004 DNA replication proofreading(GO:0045004)
2.3 6.9 GO:1902174 positive regulation of keratinocyte apoptotic process(GO:1902174)
2.1 20.7 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
1.9 13.5 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
1.9 9.4 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
1.9 7.4 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
1.7 18.5 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
1.6 29.5 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
1.5 38.6 GO:0006270 DNA replication initiation(GO:0006270)
1.3 10.4 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
1.0 5.1 GO:0002121 inter-male aggressive behavior(GO:0002121) response to pheromone(GO:0019236)
0.9 2.8 GO:0019046 release from viral latency(GO:0019046) regulation of DNA strand elongation(GO:0060382)
0.9 5.6 GO:0002317 plasma cell differentiation(GO:0002317) positive regulation of viral entry into host cell(GO:0046598)
0.8 10.4 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.8 4.7 GO:0033600 negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
0.6 5.0 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.6 3.9 GO:0046549 phenol-containing compound catabolic process(GO:0019336) retinal cone cell development(GO:0046549)
0.5 16.6 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.4 8.8 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.3 1.0 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.3 1.3 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.2 2.2 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.2 13.1 GO:0090307 mitotic spindle assembly(GO:0090307)
0.2 0.6 GO:1904154 protein localization to endoplasmic reticulum exit site(GO:0070973) positive regulation of retrograde protein transport, ER to cytosol(GO:1904154)
0.2 9.2 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.2 6.7 GO:0033045 regulation of sister chromatid segregation(GO:0033045)
0.1 16.1 GO:0007093 mitotic cell cycle checkpoint(GO:0007093)
0.1 1.8 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.1 1.1 GO:0035562 negative regulation of chromatin binding(GO:0035562)
0.1 0.6 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.1 11.6 GO:0030010 establishment of cell polarity(GO:0030010)
0.0 0.4 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0 1.0 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 5.6 GO:0007179 transforming growth factor beta receptor signaling pathway(GO:0007179)
0.0 10.1 GO:0006897 endocytosis(GO:0006897)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
5.9 29.5 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
5.7 17.2 GO:1990423 RZZ complex(GO:1990423)
5.5 16.6 GO:0033186 CAF-1 complex(GO:0033186)
4.5 13.5 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
3.3 49.6 GO:0042555 MCM complex(GO:0042555)
3.0 8.9 GO:0043625 delta DNA polymerase complex(GO:0043625)
2.6 13.1 GO:0031523 Myb complex(GO:0031523)
1.8 9.2 GO:0035189 Rb-E2F complex(GO:0035189)
1.7 5.0 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
1.5 10.4 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
1.5 8.9 GO:0005663 DNA replication factor C complex(GO:0005663)
1.5 7.4 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
1.0 65.0 GO:0005657 replication fork(GO:0005657)
0.8 20.7 GO:0005721 pericentric heterochromatin(GO:0005721)
0.8 16.8 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.7 8.2 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.4 4.5 GO:0001673 male germ cell nucleus(GO:0001673)
0.4 12.1 GO:0051233 spindle midzone(GO:0051233)
0.2 0.6 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.2 3.5 GO:1904115 axon cytoplasm(GO:1904115)
0.1 0.6 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.1 5.1 GO:0032590 dendrite membrane(GO:0032590)
0.1 52.2 GO:0005667 transcription factor complex(GO:0005667)
0.1 9.4 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.1 1.0 GO:0071004 U2-type prespliceosome(GO:0071004)
0.0 11.2 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 1.0 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.0 3.7 GO:0000776 kinetochore(GO:0000776)
0.0 1.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 4.9 GO:0016607 nuclear speck(GO:0016607)
0.0 8.9 GO:0030424 axon(GO:0030424)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
9.7 39.0 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
5.9 29.5 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
5.7 17.2 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
3.5 10.4 GO:0071207 histone pre-mRNA stem-loop binding(GO:0071207)
3.4 47.5 GO:0003688 DNA replication origin binding(GO:0003688)
2.8 22.4 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
2.1 16.6 GO:0070087 chromo shadow domain binding(GO:0070087)
1.1 5.6 GO:0005534 galactose binding(GO:0005534)
1.0 8.9 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.8 5.0 GO:0070883 pre-miRNA binding(GO:0070883)
0.8 8.9 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.7 8.8 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.5 5.1 GO:0019992 diacylglycerol binding(GO:0019992)
0.5 18.1 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.4 13.6 GO:0017025 TBP-class protein binding(GO:0017025)
0.3 11.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.3 6.9 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.2 12.5 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.2 46.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 5.6 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.2 1.0 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.2 11.4 GO:0019955 cytokine binding(GO:0019955)
0.2 10.5 GO:0035064 methylated histone binding(GO:0035064)
0.2 7.4 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.2 20.7 GO:0004386 helicase activity(GO:0004386)
0.2 3.5 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.1 0.6 GO:0034604 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.1 7.6 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.6 GO:0042288 MHC class I protein binding(GO:0042288)
0.0 1.1 GO:0032452 histone demethylase activity(GO:0032452)
0.0 2.2 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 8.2 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 6.7 GO:0005096 GTPase activator activity(GO:0005096)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 29.7 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.9 43.1 PID_ATR_PATHWAY ATR signaling pathway
0.8 9.2 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.6 44.5 PID_E2F_PATHWAY E2F transcription factor network
0.5 20.7 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.4 14.2 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.3 16.8 PID_BMP_PATHWAY BMP receptor signaling
0.3 8.2 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.3 5.0 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.2 9.3 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.2 8.9 PID_FAS_PATHWAY FAS (CD95) signaling pathway
0.2 10.8 PID_ERBB4_PATHWAY ErbB4 signaling events
0.2 10.7 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.2 5.6 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 6.0 PID_CMYB_PATHWAY C-MYB transcription factor network
0.1 6.9 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 5.6 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.4 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
4.1 65.6 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
3.3 29.7 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
3.0 53.7 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
2.0 17.7 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
1.9 7.4 REACTOME_PROCESSIVE_SYNTHESIS_ON_THE_LAGGING_STRAND Genes involved in Processive synthesis on the lagging strand
1.2 20.6 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.9 10.4 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.7 19.6 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.4 14.2 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.4 8.2 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
0.4 3.9 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.2 5.0 REACTOME_MICRORNA_MIRNA_BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.1 9.3 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 10.8 REACTOME_SIGNALING_BY_EGFR_IN_CANCER Genes involved in Signaling by EGFR in Cancer
0.1 1.0 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.6 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 4.7 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 3.8 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.0 1.5 REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE Genes involved in Late Phase of HIV Life Cycle
0.0 0.6 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins