Motif ID: Ebf1

Z-value: 1.176


Transcription factors associated with Ebf1:

Gene SymbolEntrez IDGene Name
Ebf1 ENSMUSG00000078561.3 Ebf1
Ebf1 ENSMUSG00000057098.8 Ebf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ebf1mm10_v2_chr11_+_44617310_446173360.383.8e-03Click!


Activity profile for motif Ebf1.

activity profile for motif Ebf1


Sorted Z-values histogram for motif Ebf1

Sorted Z-values for motif Ebf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Ebf1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_172550991 9.041 ENSMUST00000170744.1
 Tfap2c
transcription factor AP-2, gamma
chr9_+_108479849 6.297 ENSMUST00000065014.4
 Lamb2
laminin, beta 2
chr2_+_172550761 6.013 ENSMUST00000099058.3
 Tfap2c
transcription factor AP-2, gamma
chr19_+_7268296 5.828 ENSMUST00000066646.4
 Rcor2
REST corepressor 2
chr17_-_35702040 5.723 ENSMUST00000166980.2
ENSMUST00000145900.1
 Ddr1

discoidin domain receptor family, member 1

chr9_-_37433138 5.511 ENSMUST00000115038.1
 Robo3
roundabout homolog 3 (Drosophila)
chr2_-_180225812 5.455 ENSMUST00000015791.5
 Lama5
laminin, alpha 5
chr1_+_135729147 5.183 ENSMUST00000027677.7
 Csrp1
cysteine and glycine-rich protein 1
chr2_+_131186942 5.136 ENSMUST00000028804.8
ENSMUST00000079857.8
 Cdc25b

cell division cycle 25B

chr9_-_58313189 5.021 ENSMUST00000061799.8
 Loxl1
lysyl oxidase-like 1
chr2_+_84840612 5.012 ENSMUST00000111625.1
 Slc43a1
solute carrier family 43, member 1
chr7_-_30973464 4.911 ENSMUST00000001279.8
 Lsr
lipolysis stimulated lipoprotein receptor
chr5_-_124095749 4.667 ENSMUST00000031354.4
 Abcb9
ATP-binding cassette, sub-family B (MDR/TAP), member 9
chr8_+_12395287 4.629 ENSMUST00000180353.1
 Sox1
SRY-box containing gene 1
chr17_-_34000257 4.619 ENSMUST00000087189.6
ENSMUST00000173075.1
ENSMUST00000172760.1
ENSMUST00000172912.1
ENSMUST00000025181.10
 H2-K1




histocompatibility 2, K1, K region




chr2_+_22622183 4.569 ENSMUST00000028123.3
 Gad2
glutamic acid decarboxylase 2
chr2_+_130295148 4.448 ENSMUST00000110288.2
 Ebf4
early B cell factor 4
chr7_-_30973367 4.443 ENSMUST00000108116.3
 Lsr
lipolysis stimulated lipoprotein receptor
chr2_+_105668888 4.312 ENSMUST00000111086.4
ENSMUST00000111087.3
 Pax6

paired box gene 6

chr11_-_114795888 4.309 ENSMUST00000000206.3
 Btbd17
BTB (POZ) domain containing 17

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 731 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 16.6 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
5.0 15.1 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
1.7 14.0 GO:2001198 regulation of dendritic cell differentiation(GO:2001198)
4.4 13.1 GO:1904274 tricellular tight junction assembly(GO:1904274)
1.6 8.1 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
0.6 7.9 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
1.5 7.7 GO:0048682 axon extension involved in regeneration(GO:0048677) sprouting of injured axon(GO:0048682)
1.5 7.5 GO:0046864 retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865) alveolar primary septum development(GO:0061143)
1.3 6.7 GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996)
0.8 6.6 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.2 6.6 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.7 6.4 GO:0071493 cellular response to UV-B(GO:0071493)
1.0 6.1 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
1.1 5.7 GO:0034421 post-translational protein acetylation(GO:0034421)
0.2 5.7 GO:1902186 regulation of viral release from host cell(GO:1902186)
1.4 5.6 GO:0051316 attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation(GO:0051316)
0.7 5.6 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.6 5.6 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
1.1 5.5 GO:0061642 chemoattraction of axon(GO:0061642)
0.3 5.5 GO:0001886 endothelial cell morphogenesis(GO:0001886)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 261 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 48.0 GO:0070062 extracellular exosome(GO:0070062)
0.1 33.2 GO:0005667 transcription factor complex(GO:0005667)
0.1 13.7 GO:0000790 nuclear chromatin(GO:0000790)
2.2 13.1 GO:0061689 tricellular tight junction(GO:0061689)
0.0 13.0 GO:0031012 extracellular matrix(GO:0031012)
2.0 11.8 GO:0043256 laminin complex(GO:0043256)
0.2 11.4 GO:0000791 euchromatin(GO:0000791)
0.1 8.1 GO:0005604 basement membrane(GO:0005604)
1.3 7.8 GO:0031262 Ndc80 complex(GO:0031262)
0.7 7.8 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 7.8 GO:0017053 transcriptional repressor complex(GO:0017053)
2.5 7.5 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.1 7.5 GO:0000922 spindle pole(GO:0000922)
0.1 7.0 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 7.0 GO:0005814 centriole(GO:0005814)
0.7 6.6 GO:0000796 condensin complex(GO:0000796)
1.3 6.5 GO:0032133 chromosome passenger complex(GO:0032133)
1.5 6.2 GO:0000939 condensed chromosome inner kinetochore(GO:0000939)
0.3 6.2 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 6.1 GO:0022626 cytosolic ribosome(GO:0022626)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 424 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 29.4 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.3 27.0 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
1.9 16.7 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.9 14.8 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.8 12.2 GO:0003680 AT DNA binding(GO:0003680)
0.2 11.7 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1 8.6 GO:0005178 integrin binding(GO:0005178)
0.2 8.3 GO:0005201 extracellular matrix structural constituent(GO:0005201)
1.2 8.1 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.7 7.7 GO:0046977 TAP binding(GO:0046977)
1.9 7.5 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.6 7.4 GO:0044548 S100 protein binding(GO:0044548)
0.2 7.1 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 6.9 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.5 6.7 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
2.2 6.6 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.4 6.6 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 6.6 GO:0003735 structural constituent of ribosome(GO:0003735)
1.6 6.5 GO:0003844 1,4-alpha-glucan branching enzyme activity(GO:0003844)
0.1 6.3 GO:0008536 Ran GTPase binding(GO:0008536)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 94 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 19.5 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 16.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 16.2 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 14.4 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.2 13.8 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
1.4 11.4 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.2 10.3 NABA_COLLAGENS Genes encoding collagen proteins
1.0 9.3 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 8.4 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.2 7.4 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.2 7.2 PID_BARD1_PATHWAY BARD1 signaling events
0.2 6.4 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 6.4 PID_PLK1_PATHWAY PLK1 signaling events
0.3 5.4 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.1 5.2 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.3 4.9 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.2 4.5 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.1 4.2 PID_CDC42_PATHWAY CDC42 signaling events
0.1 3.6 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 3.6 NABA_PROTEOGLYCANS Genes encoding proteoglycans

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 129 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 28.5 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 19.0 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.5 12.3 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.3 10.4 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.2 8.4 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.6 8.0 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.4 7.6 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.2 7.2 REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.4 7.0 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.3 6.8 REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.2 6.6 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2 6.6 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.2 6.3 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 6.2 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.3 6.0 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 5.9 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 5.8 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.3 5.5 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.2 5.3 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.5 5.0 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones