Motif ID: Egr1

Z-value: 2.754


Transcription factors associated with Egr1:

Gene SymbolEntrez IDGene Name
Egr1 ENSMUSG00000038418.7 Egr1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Egr1mm10_v2_chr18_+_34861200_34861215-0.211.2e-01Click!


Activity profile for motif Egr1.

activity profile for motif Egr1


Sorted Z-values histogram for motif Egr1

Sorted Z-values for motif Egr1



Network of associatons between targets according to the STRING database.



First level regulatory network of Egr1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_6065538 58.425 ENSMUST00000101585.3
ENSMUST00000066431.7
ENSMUST00000109815.2
ENSMUST00000109812.2
ENSMUST00000101586.2
ENSMUST00000093355.5
ENSMUST00000019133.4
 Camk2b






calcium/calmodulin-dependent protein kinase II, beta






chr11_-_67922136 26.483 ENSMUST00000021288.3
ENSMUST00000108677.1
 Usp43

ubiquitin specific peptidase 43

chr14_-_33447142 22.628 ENSMUST00000111944.3
ENSMUST00000022504.5
ENSMUST00000111945.2
 Mapk8


mitogen-activated protein kinase 8


chr5_-_139129662 22.466 ENSMUST00000026973.7
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr11_+_119942763 22.209 ENSMUST00000026436.3
ENSMUST00000106231.1
ENSMUST00000075180.5
ENSMUST00000103021.3
ENSMUST00000106233.1
 Baiap2




brain-specific angiogenesis inhibitor 1-associated protein 2




chr5_-_139130159 22.020 ENSMUST00000129851.1
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr11_+_98348404 21.729 ENSMUST00000078694.6
 Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr7_+_73740277 21.139 ENSMUST00000107456.2
 Fam174b
family with sequence similarity 174, member B
chr14_-_102982630 19.761 ENSMUST00000184744.1
 KCTD12
mmu-mir-5130
chr4_+_127169131 19.228 ENSMUST00000046659.7
 Dlgap3
discs, large (Drosophila) homolog-associated protein 3
chr11_-_6065737 18.767 ENSMUST00000002817.5
ENSMUST00000109813.2
ENSMUST00000090443.3
 Camk2b


calcium/calmodulin-dependent protein kinase II, beta


chr5_+_137288273 18.552 ENSMUST00000024099.4
ENSMUST00000085934.3
 Ache

acetylcholinesterase

chr7_+_82175156 18.414 ENSMUST00000180243.1
 Sh3gl3
SH3-domain GRB2-like 3
chr7_-_27396542 18.309 ENSMUST00000108363.1
 Sptbn4
spectrin beta, non-erythrocytic 4
chr9_-_102354685 18.053 ENSMUST00000035129.7
ENSMUST00000085169.5
 Ephb1

Eph receptor B1

chr3_+_54156039 17.872 ENSMUST00000029311.6
 Trpc4
transient receptor potential cation channel, subfamily C, member 4
chrX_-_20920911 17.098 ENSMUST00000081893.6
ENSMUST00000115345.1
 Syn1

synapsin I

chr7_+_82174796 16.741 ENSMUST00000032874.7
 Sh3gl3
SH3-domain GRB2-like 3
chr4_+_42917234 15.781 ENSMUST00000107976.2
ENSMUST00000069184.2
 N28178

expressed sequence N28178

chr5_+_32136458 15.580 ENSMUST00000031017.9
 Fosl2
fos-like antigen 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 251 entries
Log-likelihood per target Total log-likelihoodTermDescription
25.7 77.2 GO:0032430 inhibitory G-protein coupled receptor phosphorylation(GO:0002030) positive regulation of phospholipase A2 activity(GO:0032430) activation of meiosis involved in egg activation(GO:0060466)
3.7 44.7 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
2.9 37.5 GO:0016191 synaptic vesicle uncoating(GO:0016191)
6.2 30.8 GO:2000325 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
1.3 27.9 GO:0006491 N-glycan processing(GO:0006491)
1.8 27.0 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
1.5 26.2 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.1 24.5 GO:0006813 potassium ion transport(GO:0006813)
1.5 24.0 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
3.9 23.4 GO:0032796 uropod organization(GO:0032796)
7.6 22.7 GO:1900039 positive regulation of cellular response to hypoxia(GO:1900039)
5.7 22.6 GO:2000017 positive regulation of determination of dorsal identity(GO:2000017)
7.2 21.7 GO:0007621 negative regulation of female receptivity(GO:0007621)
2.7 21.6 GO:0005513 detection of calcium ion(GO:0005513)
4.2 21.0 GO:0007256 activation of JNKK activity(GO:0007256)
1.2 20.9 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
0.2 20.2 GO:0016579 protein deubiquitination(GO:0016579)
0.4 19.3 GO:0034605 cellular response to heat(GO:0034605)
3.1 18.6 GO:0019695 choline metabolic process(GO:0019695)
6.1 18.3 GO:1900673 olefin metabolic process(GO:1900673)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 135 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 78.2 GO:0051233 spindle midzone(GO:0051233)
0.9 76.3 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
3.8 49.2 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.2 47.0 GO:0005769 early endosome(GO:0005769)
0.9 42.5 GO:0034704 calcium channel complex(GO:0034704)
0.1 31.4 GO:0043025 neuronal cell body(GO:0043025)
1.1 28.5 GO:0032839 dendrite cytoplasm(GO:0032839)
4.6 27.6 GO:0008091 spectrin(GO:0008091)
0.2 27.1 GO:0055037 recycling endosome(GO:0055037)
2.3 23.4 GO:0032426 stereocilium tip(GO:0032426)
0.8 23.4 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.3 23.1 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
3.8 22.7 GO:0044305 calyx of Held(GO:0044305)
3.2 19.3 GO:0005955 calcineurin complex(GO:0005955)
1.5 19.2 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
1.2 19.2 GO:1990635 proximal dendrite(GO:1990635)
0.1 18.9 GO:0000139 Golgi membrane(GO:0000139)
1.4 18.6 GO:0043083 synaptic cleft(GO:0043083)
4.6 18.3 GO:0044307 dendritic branch(GO:0044307)
1.2 18.1 GO:0032433 filopodium tip(GO:0032433)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 186 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.4 88.9 GO:0043274 phospholipase binding(GO:0043274)
4.0 44.5 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
2.1 37.2 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
2.6 36.3 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
2.7 29.6 GO:0022841 potassium ion leak channel activity(GO:0022841)
2.5 27.9 GO:0015924 mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.3 26.1 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
2.1 23.4 GO:0032036 myosin heavy chain binding(GO:0032036)
5.7 22.6 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
2.8 22.2 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
7.2 21.7 GO:0031752 D3 dopamine receptor binding(GO:0031750) D5 dopamine receptor binding(GO:0031752)
1.4 21.7 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.4 20.4 GO:0001784 phosphotyrosine binding(GO:0001784)
1.4 19.8 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
4.6 18.6 GO:0004104 cholinesterase activity(GO:0004104) choline binding(GO:0033265)
0.3 18.4 GO:0051219 phosphoprotein binding(GO:0051219)
3.0 18.3 GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.4 18.3 GO:0030507 spectrin binding(GO:0030507)
5.8 17.5 GO:0070615 nucleosome-dependent ATPase activity(GO:0070615)
5.7 17.0 GO:0034437 very-low-density lipoprotein particle binding(GO:0034189) glycoprotein transporter activity(GO:0034437)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.3 76.1 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.5 50.4 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.9 38.4 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.9 32.5 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
1.7 29.5 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.5 27.4 PID_RAC1_PATHWAY RAC1 signaling pathway
1.7 24.4 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.6 23.3 PID_IL8_CXCR2_PATHWAY IL8- and CXCR2-mediated signaling events
0.8 22.9 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 19.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.5 19.2 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.5 17.4 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.7 17.0 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.3 16.7 PID_LKB1_PATHWAY LKB1 signaling events
0.4 16.4 PID_CD8_TCR_PATHWAY TCR signaling in naïve CD8+ T cells
0.4 15.9 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.6 14.9 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 14.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.6 12.2 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.3 12.0 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.8 95.5 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
2.9 64.0 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
1.2 49.6 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
1.6 42.1 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
2.0 29.9 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
4.2 29.6 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.4 27.6 REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH Genes involved in NCAM signaling for neurite out-growth
1.0 25.7 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.7 20.4 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
1.8 20.1 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.8 18.6 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
1.6 17.8 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.4 17.1 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.8 16.3 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.8 14.5 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.5 12.0 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.1 11.8 REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE Genes involved in Cell death signalling via NRAGE, NRIF and NADE
0.7 10.7 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
1.3 10.4 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.6 10.3 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation