Motif ID: Egr3

Z-value: 0.668


Transcription factors associated with Egr3:

Gene SymbolEntrez IDGene Name
Egr3 ENSMUSG00000033730.3 Egr3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Egr3mm10_v2_chr14_+_70077375_700774450.358.9e-03Click!


Activity profile for motif Egr3.

activity profile for motif Egr3


Sorted Z-values histogram for motif Egr3

Sorted Z-values for motif Egr3



Network of associatons between targets according to the STRING database.



First level regulatory network of Egr3

PNG image of the network

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Top targets:


Showing 1 to 20 of 102 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_119184374 5.101 ENSMUST00000084650.4
 Gpr139
G protein-coupled receptor 139
chr4_+_123183722 3.187 ENSMUST00000152194.1
 Hpcal4
hippocalcin-like 4
chr6_-_144209558 2.523 ENSMUST00000111749.1
ENSMUST00000170367.2
 Sox5

SRY-box containing gene 5

chr4_+_123183456 2.519 ENSMUST00000126995.1
 Hpcal4
hippocalcin-like 4
chr12_-_67221221 2.404 ENSMUST00000178814.1
ENSMUST00000179345.2
 Mdga2
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
MAM domain-containing glycosylphosphatidylinositol anchor protein 2
chr17_-_87282771 2.264 ENSMUST00000161759.1
 4833418N02Rik
RIKEN cDNA 4833418N02 gene
chr17_+_87282880 2.232 ENSMUST00000041110.5
ENSMUST00000125875.1
 Ttc7

tetratricopeptide repeat domain 7

chr6_-_49214954 2.229 ENSMUST00000031838.7
 Igf2bp3
insulin-like growth factor 2 mRNA binding protein 3
chr17_-_87282793 2.197 ENSMUST00000146560.2
 4833418N02Rik
RIKEN cDNA 4833418N02 gene
chr9_-_58204310 2.185 ENSMUST00000114144.2
 Islr2
immunoglobulin superfamily containing leucine-rich repeat 2
chr8_+_62951361 2.023 ENSMUST00000119068.1
 Spock3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3
chr2_+_32395896 1.811 ENSMUST00000028162.3
 Ptges2
prostaglandin E synthase 2
chr17_-_83631892 1.775 ENSMUST00000051482.1
 Kcng3
potassium voltage-gated channel, subfamily G, member 3
chr10_+_40883819 1.663 ENSMUST00000105509.1
 Wasf1
WAS protein family, member 1
chr11_-_109722214 1.659 ENSMUST00000020938.7
 Fam20a
family with sequence similarity 20, member A
chr8_+_104170513 1.487 ENSMUST00000171018.1
ENSMUST00000167633.1
ENSMUST00000093245.5
ENSMUST00000164076.1
 Bean1



brain expressed, associated with Nedd4, 1



chr7_-_110061319 1.458 ENSMUST00000098110.2
 AA474408
expressed sequence AA474408
chr10_+_40883469 1.454 ENSMUST00000019975.7
 Wasf1
WAS protein family, member 1
chrX_+_143664290 1.425 ENSMUST00000112868.1
 Pak3
p21 protein (Cdc42/Rac)-activated kinase 3
chrX_+_143664365 1.416 ENSMUST00000126592.1
ENSMUST00000156449.1
ENSMUST00000155215.1
ENSMUST00000112865.1
 Pak3



p21 protein (Cdc42/Rac)-activated kinase 3




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.1 GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway(GO:0007200)
0.4 4.8 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.4 3.1 GO:1990416 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.1 2.8 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.3 2.5 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.0 2.3 GO:0045773 positive regulation of axon extension(GO:0045773)
0.0 2.2 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.0 2.2 GO:0051028 mRNA transport(GO:0051028)
0.2 2.0 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 1.8 GO:0001516 prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457)
0.3 1.7 GO:0070166 enamel mineralization(GO:0070166)
0.4 1.2 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.2 1.2 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.2 1.1 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)
0.1 1.1 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.3 1.0 GO:0010871 negative regulation of receptor biosynthetic process(GO:0010871)
0.2 1.0 GO:0007403 glial cell fate determination(GO:0007403)
0.2 1.0 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.2 0.9 GO:2000705 regulation of dense core granule biogenesis(GO:2000705)
0.2 0.9 GO:0046684 response to pyrethroid(GO:0046684)

Gene overrepresentation in cellular_component category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.8 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 3.5 GO:0031225 anchored component of membrane(GO:0031225)
0.2 3.1 GO:0031209 SCAR complex(GO:0031209)
0.0 2.3 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 1.3 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 1.2 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 1.1 GO:0031430 M band(GO:0031430)
0.1 1.0 GO:0005726 perichromatin fibrils(GO:0005726)
0.1 0.9 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.2 0.6 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.1 0.6 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.4 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.3 GO:0042825 TAP complex(GO:0042825)
0.0 0.3 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0 0.3 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.3 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.3 GO:0097228 sperm principal piece(GO:0097228)
0.1 0.2 GO:0031417 NatC complex(GO:0031417)
0.0 0.2 GO:0031143 pseudopodium(GO:0031143)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.9 GO:0030507 spectrin binding(GO:0030507)
0.1 5.7 GO:0005246 calcium channel regulator activity(GO:0005246)
0.3 5.1 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.1 3.4 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 3.1 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 3.0 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.2 2.0 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.5 1.8 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.1 1.8 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 1.7 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.3 1.2 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.0 1.1 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.1 1.0 GO:0005522 profilin binding(GO:0005522)
0.1 1.0 GO:0001163 RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.0 1.0 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 0.9 GO:0031402 sodium ion binding(GO:0031402)
0.1 0.6 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.1 0.6 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 0.5 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.5 GO:0016427 tRNA (cytosine) methyltransferase activity(GO:0016427)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.0 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.1 2.0 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 2.0 PID_IFNG_PATHWAY IFN-gamma pathway
0.0 1.6 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.2 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 1.0 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.1 1.0 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.5 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 0.2 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.8 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 2.3 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 2.2 REACTOME_DIABETES_PATHWAYS Genes involved in Diabetes pathways
0.0 1.7 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.1 1.0 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules
0.0 1.0 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 0.6 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.5 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 0.5 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.5 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.3 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.3 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.3 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.3 REACTOME_KINESINS Genes involved in Kinesins
0.0 0.2 REACTOME_RAF_MAP_KINASE_CASCADE Genes involved in RAF/MAP kinase cascade