Motif ID: Egr4

Z-value: 0.670


Transcription factors associated with Egr4:

Gene SymbolEntrez IDGene Name
Egr4 ENSMUSG00000071341.3 Egr4



Activity profile for motif Egr4.

activity profile for motif Egr4


Sorted Z-values histogram for motif Egr4

Sorted Z-values for motif Egr4



Network of associatons between targets according to the STRING database.



First level regulatory network of Egr4

PNG image of the network

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Top targets:


Showing 1 to 20 of 106 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_70851189 8.194 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr11_-_19018956 4.849 ENSMUST00000068264.7
ENSMUST00000144988.1
ENSMUST00000185131.1
 Meis1


Meis homeobox 1


chr13_+_48261427 4.215 ENSMUST00000021810.1
 Id4
inhibitor of DNA binding 4
chr2_-_102186322 3.962 ENSMUST00000111222.1
ENSMUST00000058790.5
 Ldlrad3

low density lipoprotein receptor class A domain containing 3

chr18_+_35829798 3.950 ENSMUST00000060722.6
 Cxxc5
CXXC finger 5
chr11_-_19018714 3.542 ENSMUST00000177417.1
 Meis1
Meis homeobox 1
chr19_+_25505618 3.250 ENSMUST00000025755.4
 Dmrt1
doublesex and mab-3 related transcription factor 1
chr10_-_81350389 2.651 ENSMUST00000020454.4
ENSMUST00000105324.2
ENSMUST00000154609.2
ENSMUST00000105323.1
 Hmg20b



high mobility group 20B



chr4_+_128883549 2.647 ENSMUST00000035667.8
 Trim62
tripartite motif-containing 62
chr12_+_17690793 2.570 ENSMUST00000071858.3
 Hpcal1
hippocalcin-like 1
chr19_-_50678642 2.489 ENSMUST00000072685.6
ENSMUST00000164039.2
 Sorcs1

VPS10 domain receptor protein SORCS 1

chr10_-_81350191 2.470 ENSMUST00000122993.1
 Hmg20b
high mobility group 20B
chr10_+_19591949 2.458 ENSMUST00000020188.6
 Ifngr1
interferon gamma receptor 1
chr6_+_4747306 2.445 ENSMUST00000175823.1
ENSMUST00000176204.1
ENSMUST00000166678.1
 Peg10


paternally expressed 10


chr17_-_23677432 2.381 ENSMUST00000167059.1
ENSMUST00000024698.8
 Tnfrsf12a

tumor necrosis factor receptor superfamily, member 12a

chr4_+_86748526 2.342 ENSMUST00000082026.7
ENSMUST00000045512.8
 Dennd4c

DENN/MADD domain containing 4C

chr10_-_81350305 2.263 ENSMUST00000167481.1
 Hmg20b
high mobility group 20B
chr11_-_86993682 2.147 ENSMUST00000018571.4
 Ypel2
yippee-like 2 (Drosophila)
chr14_-_54926784 2.145 ENSMUST00000022813.6
 Efs
embryonal Fyn-associated substrate
chr12_+_76370266 2.121 ENSMUST00000042779.3
 Zbtb1
zinc finger and BTB domain containing 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 11.4 GO:0038092 nodal signaling pathway(GO:0038092)
0.4 8.4 GO:0060044 negative regulation of cardiac muscle cell proliferation(GO:0060044)
0.4 7.4 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
1.1 4.2 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
0.1 4.0 GO:0070613 regulation of protein processing(GO:0070613)
0.0 4.0 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.1 3.8 GO:0006783 heme biosynthetic process(GO:0006783)
0.1 2.6 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.0 2.5 GO:0051607 defense response to virus(GO:0051607)
0.8 2.4 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.0 2.4 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.5 2.1 GO:0002572 pro-T cell differentiation(GO:0002572)
0.1 2.1 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.7 2.0 GO:0045819 plasmacytoid dendritic cell activation(GO:0002270) positive regulation of glycogen catabolic process(GO:0045819)
0.7 2.0 GO:1904975 response to bleomycin(GO:1904975) cellular response to bleomycin(GO:1904976)
0.1 2.0 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.5 1.9 GO:0044340 canonical Wnt signaling pathway involved in regulation of cell proliferation(GO:0044340)
0.0 1.9 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.6 1.8 GO:0003100 angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001998) regulation of blood vessel size by renin-angiotensin(GO:0002034) renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure(GO:0003072) regulation of systemic arterial blood pressure by endothelin(GO:0003100) beta selection(GO:0043366) response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869)
0.2 1.8 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.7 GO:0005667 transcription factor complex(GO:0005667)
1.8 7.4 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
0.0 7.2 GO:0001726 ruffle(GO:0001726)
0.0 2.6 GO:0005681 spliceosomal complex(GO:0005681)
0.0 2.4 GO:0016235 aggresome(GO:0016235)
0.1 2.3 GO:0032593 insulin-responsive compartment(GO:0032593)
0.6 1.7 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.1 1.7 GO:0030914 STAGA complex(GO:0030914)
0.0 1.7 GO:1990391 DNA repair complex(GO:1990391)
0.2 1.5 GO:0089701 U2AF(GO:0089701)
0.0 1.5 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.4 1.3 GO:0033186 CAF-1 complex(GO:0033186)
0.1 1.3 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 1.2 GO:0045298 tubulin complex(GO:0045298)
0.0 1.2 GO:0000788 nuclear nucleosome(GO:0000788)
0.4 1.1 GO:0005577 fibrinogen complex(GO:0005577)
0.1 1.1 GO:0016461 unconventional myosin complex(GO:0016461)
0.1 1.1 GO:1990909 Wnt signalosome(GO:1990909)
0.1 1.1 GO:0031011 Ino80 complex(GO:0031011)
0.1 1.1 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.9 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.4 8.2 GO:0070410 co-SMAD binding(GO:0070410)
0.4 7.4 GO:0000400 four-way junction DNA binding(GO:0000400)
0.0 7.2 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 6.6 GO:0008134 transcription factor binding(GO:0008134)
0.0 4.2 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 4.2 GO:0042393 histone binding(GO:0042393)
0.0 2.9 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 2.5 GO:0004896 cytokine receptor activity(GO:0004896)
0.1 2.3 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 2.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 2.1 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 2.1 GO:0017124 SH3 domain binding(GO:0017124)
0.7 2.0 GO:0000402 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)
0.0 1.9 GO:0005109 frizzled binding(GO:0005109)
0.2 1.8 GO:0051022 Rho GDP-dissociation inhibitor binding(GO:0051022)
0.0 1.8 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 1.7 GO:0001013 RNA polymerase I regulatory region DNA binding(GO:0001013)
0.0 1.7 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 1.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.2 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 4.3 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.1 3.0 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.2 2.5 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.0 2.4 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 2.1 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.0 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.1 2.0 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 1.9 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 1.8 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.1 1.6 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 1.6 PID_E2F_PATHWAY E2F transcription factor network
0.1 1.5 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.1 1.4 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.2 PID_PLK1_PATHWAY PLK1 signaling events
0.0 1.2 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.1 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 1.0 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 0.6 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.5 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 9.8 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 8.3 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 3.2 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.2 2.5 REACTOME_REGULATION_OF_IFNG_SIGNALING Genes involved in Regulation of IFNG signaling
0.1 2.2 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.1 2.1 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.1 1.8 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 1.5 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.1 1.1 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 1.1 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 1.1 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 1.1 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 0.9 REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.0 0.6 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.5 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells