Motif ID: Egr4

Z-value: 0.670


Transcription factors associated with Egr4:

Gene SymbolEntrez IDGene Name
Egr4 ENSMUSG00000071341.3 Egr4



Activity profile for motif Egr4.

activity profile for motif Egr4


Sorted Z-values histogram for motif Egr4

Sorted Z-values for motif Egr4



Network of associatons between targets according to the STRING database.



First level regulatory network of Egr4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_70851189 8.194 ENSMUST00000059775.8
Tgif1
TGFB-induced factor homeobox 1
chr11_-_19018956 4.849 ENSMUST00000068264.7
ENSMUST00000144988.1
ENSMUST00000185131.1
Meis1


Meis homeobox 1


chr13_+_48261427 4.215 ENSMUST00000021810.1
Id4
inhibitor of DNA binding 4
chr2_-_102186322 3.962 ENSMUST00000111222.1
ENSMUST00000058790.5
Ldlrad3

low density lipoprotein receptor class A domain containing 3

chr18_+_35829798 3.950 ENSMUST00000060722.6
Cxxc5
CXXC finger 5
chr11_-_19018714 3.542 ENSMUST00000177417.1
Meis1
Meis homeobox 1
chr19_+_25505618 3.250 ENSMUST00000025755.4
Dmrt1
doublesex and mab-3 related transcription factor 1
chr10_-_81350389 2.651 ENSMUST00000020454.4
ENSMUST00000105324.2
ENSMUST00000154609.2
ENSMUST00000105323.1
Hmg20b



high mobility group 20B



chr4_+_128883549 2.647 ENSMUST00000035667.8
Trim62
tripartite motif-containing 62
chr12_+_17690793 2.570 ENSMUST00000071858.3
Hpcal1
hippocalcin-like 1
chr19_-_50678642 2.489 ENSMUST00000072685.6
ENSMUST00000164039.2
Sorcs1

VPS10 domain receptor protein SORCS 1

chr10_-_81350191 2.470 ENSMUST00000122993.1
Hmg20b
high mobility group 20B
chr10_+_19591949 2.458 ENSMUST00000020188.6
Ifngr1
interferon gamma receptor 1
chr6_+_4747306 2.445 ENSMUST00000175823.1
ENSMUST00000176204.1
ENSMUST00000166678.1
Peg10


paternally expressed 10


chr17_-_23677432 2.381 ENSMUST00000167059.1
ENSMUST00000024698.8
Tnfrsf12a

tumor necrosis factor receptor superfamily, member 12a

chr4_+_86748526 2.342 ENSMUST00000082026.7
ENSMUST00000045512.8
Dennd4c

DENN/MADD domain containing 4C

chr10_-_81350305 2.263 ENSMUST00000167481.1
Hmg20b
high mobility group 20B
chr11_-_86993682 2.147 ENSMUST00000018571.4
Ypel2
yippee-like 2 (Drosophila)
chr14_-_54926784 2.145 ENSMUST00000022813.6
Efs
embryonal Fyn-associated substrate
chr12_+_76370266 2.121 ENSMUST00000042779.3
Zbtb1
zinc finger and BTB domain containing 1
chr14_+_79481164 2.013 ENSMUST00000040131.5
Elf1
E74-like factor 1
chr5_-_149051604 1.989 ENSMUST00000093196.4
Hmgb1
high mobility group box 1
chr10_+_128232065 1.978 ENSMUST00000055539.4
ENSMUST00000105244.1
ENSMUST00000105243.2
ENSMUST00000125289.1
ENSMUST00000105242.1
Timeless




timeless circadian clock 1




chr2_+_32535315 1.940 ENSMUST00000133512.1
ENSMUST00000048375.5
Fam102a

family with sequence similarity 102, member A

chr11_+_70000578 1.868 ENSMUST00000019362.8
Dvl2
dishevelled 2, dsh homolog (Drosophila)
chr13_-_55513427 1.858 ENSMUST00000069929.6
ENSMUST00000069968.6
ENSMUST00000131306.1
ENSMUST00000046246.6
Pdlim7



PDZ and LIM domain 7



chr9_+_65630552 1.843 ENSMUST00000055844.8
Rbpms2
RNA binding protein with multiple splicing 2
chr9_+_108306205 1.802 ENSMUST00000007959.8
Rhoa
ras homolog gene family, member A
chr2_+_92184106 1.732 ENSMUST00000111294.1
ENSMUST00000111293.2
ENSMUST00000162146.1
ENSMUST00000111292.1
ENSMUST00000162497.1
Phf21a




PHD finger protein 21A




chr7_+_35119285 1.723 ENSMUST00000042985.9
Cebpa
CCAAT/enhancer binding protein (C/EBP), alpha
chr16_+_36071624 1.630 ENSMUST00000164916.1
ENSMUST00000163352.1
Ccdc58

coiled-coil domain containing 58

chrX_+_7762652 1.606 ENSMUST00000077680.3
ENSMUST00000079542.6
ENSMUST00000115679.1
ENSMUST00000137467.1
Tfe3



transcription factor E3



chr3_+_135438722 1.590 ENSMUST00000166033.1
Ube2d3
ubiquitin-conjugating enzyme E2D 3
chrX_-_48513518 1.497 ENSMUST00000114945.2
ENSMUST00000037349.7
Aifm1

apoptosis-inducing factor, mitochondrion-associated 1

chr17_-_31658729 1.486 ENSMUST00000166526.1
ENSMUST00000014684.4
U2af1

U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1

chr1_-_52500679 1.451 ENSMUST00000069792.7
Nab1
Ngfi-A binding protein 1
chr8_-_92355764 1.407 ENSMUST00000180102.1
ENSMUST00000179421.1
ENSMUST00000179222.1
ENSMUST00000179029.1
4933436C20Rik



RIKEN cDNA 4933436C20 gene



chr11_-_102407899 1.368 ENSMUST00000124755.1
Slc25a39
solute carrier family 25, member 39
chr11_-_102407315 1.360 ENSMUST00000149777.1
ENSMUST00000154001.1
Slc25a39

solute carrier family 25, member 39

chrX_-_145505175 1.354 ENSMUST00000143610.1
Amot
angiomotin
chr19_-_50678485 1.340 ENSMUST00000111756.3
Sorcs1
VPS10 domain receptor protein SORCS 1
chr5_-_96161742 1.330 ENSMUST00000129646.1
ENSMUST00000113005.2
ENSMUST00000154500.1
ENSMUST00000141383.1
Cnot6l



CCR4-NOT transcription complex, subunit 6-like



chr14_-_79481268 1.303 ENSMUST00000022601.5
Wbp4
WW domain binding protein 4
chr16_+_93883895 1.267 ENSMUST00000023666.4
ENSMUST00000117099.1
ENSMUST00000142316.1
Chaf1b


chromatin assembly factor 1, subunit B (p60)


chr6_-_28261907 1.246 ENSMUST00000115320.1
ENSMUST00000123098.1
ENSMUST00000115321.2
ENSMUST00000155494.1
Zfp800



zinc finger protein 800



chr16_+_64851991 1.231 ENSMUST00000067744.7
Cggbp1
CGG triplet repeat binding protein 1
chr14_+_56668242 1.230 ENSMUST00000116468.1
Mphosph8
M-phase phosphoprotein 8
chr2_+_124610278 1.230 ENSMUST00000051419.8
ENSMUST00000077847.5
ENSMUST00000078621.5
ENSMUST00000076335.5
Sema6d



sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D



chr9_+_118926453 1.166 ENSMUST00000073109.5
Ctdspl
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
chr14_+_75845093 1.157 ENSMUST00000110894.2
Tpt1
tumor protein, translationally-controlled 1
chr15_+_58141397 1.153 ENSMUST00000067563.7
Wdyhv1
WDYHV motif containing 1
chr4_+_130055010 1.137 ENSMUST00000123617.1
Col16a1
collagen, type XVI, alpha 1
chr2_-_119477613 1.128 ENSMUST00000110808.1
ENSMUST00000049920.7
Ino80

INO80 homolog (S. cerevisiae)

chr11_-_102407455 1.106 ENSMUST00000107098.1
ENSMUST00000018821.2
Slc25a39

solute carrier family 25, member 39

chr15_-_36608959 1.102 ENSMUST00000001809.8
Pabpc1
poly(A) binding protein, cytoplasmic 1
chr2_+_118111876 1.095 ENSMUST00000039559.8
Thbs1
thrombospondin 1
chr17_+_26138661 1.094 ENSMUST00000074370.3
ENSMUST00000118904.2
ENSMUST00000163421.1
Axin1


axin 1


chr11_-_87987528 1.058 ENSMUST00000020775.2
Dynll2
dynein light chain LC8-type 2
chrX_-_153037549 1.018 ENSMUST00000051484.3
Mageh1
melanoma antigen, family H, 1
chr1_-_36939521 0.973 ENSMUST00000027290.5
Tmem131
transmembrane protein 131
chr16_-_36071515 0.885 ENSMUST00000004057.7
Fam162a
family with sequence similarity 162, member A
chr2_+_124610573 0.878 ENSMUST00000103239.3
ENSMUST00000103240.2
Sema6d

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D

chr8_-_92356103 0.869 ENSMUST00000034183.3
4933436C20Rik
RIKEN cDNA 4933436C20 gene
chr2_-_48949206 0.867 ENSMUST00000090976.3
ENSMUST00000149679.1
ENSMUST00000028098.4
Orc4


origin recognition complex, subunit 4


chr15_+_26309039 0.794 ENSMUST00000140840.1
ENSMUST00000152841.1
March11

membrane-associated ring finger (C3HC4) 11

chr11_+_114851507 0.787 ENSMUST00000177952.1
Gprc5c
G protein-coupled receptor, family C, group 5, member C
chr6_-_85451248 0.770 ENSMUST00000113770.1
ENSMUST00000032080.2
Pradc1

protease-associated domain containing 1

chr11_+_114851814 0.691 ENSMUST00000053361.5
ENSMUST00000021071.7
ENSMUST00000136785.1
Gprc5c


G protein-coupled receptor, family C, group 5, member C


chr19_-_8786272 0.679 ENSMUST00000176610.1
ENSMUST00000177056.1
Taf6l

TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor

chr19_-_8786245 0.645 ENSMUST00000177216.1
Taf6l
TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor
chr14_+_84443553 0.632 ENSMUST00000071370.5
Pcdh17
protocadherin 17
chrX_+_36195968 0.629 ENSMUST00000115256.1
Zcchc12
zinc finger, CCHC domain containing 12
chrX_-_143393893 0.620 ENSMUST00000166406.2
Chrdl1
chordin-like 1
chr3_+_144570687 0.610 ENSMUST00000106211.1
Sep15
selenoprotein
chr17_+_69383024 0.527 ENSMUST00000112674.1
Zbtb14
zinc finger and BTB domain containing 14
chr16_-_4213404 0.515 ENSMUST00000023165.6
Crebbp
CREB binding protein
chr19_+_6363719 0.508 ENSMUST00000113489.1
ENSMUST00000113488.1
Sf1

splicing factor 1

chr2_-_148045891 0.499 ENSMUST00000109964.1
Foxa2
forkhead box A2
chr7_-_19404082 0.450 ENSMUST00000108458.3
Klc3
kinesin light chain 3
chr19_+_6363671 0.427 ENSMUST00000131252.1
Sf1
splicing factor 1
chr19_-_21652779 0.396 ENSMUST00000179768.1
ENSMUST00000178523.1
ENSMUST00000038830.3
1110059E24Rik


RIKEN cDNA 1110059E24 gene


chr19_+_6306456 0.392 ENSMUST00000025681.7
Cdc42bpg
CDC42 binding protein kinase gamma (DMPK-like)
chr19_+_6363896 0.366 ENSMUST00000113487.1
Sf1
splicing factor 1
chrX_-_20291728 0.358 ENSMUST00000115393.2
Slc9a7
solute carrier family 9 (sodium/hydrogen exchanger), member 7
chr19_-_8786408 0.329 ENSMUST00000176496.1
Taf6l
TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor
chr7_-_4778141 0.320 ENSMUST00000094892.5
Il11
interleukin 11
chr7_-_63938862 0.313 ENSMUST00000063694.8
Klf13
Kruppel-like factor 13
chr2_-_9883993 0.302 ENSMUST00000114915.2
9230102O04Rik
RIKEN cDNA 9230102O04 gene
chr9_-_59750616 0.274 ENSMUST00000163586.1
ENSMUST00000177963.1
ENSMUST00000051039.4
Senp8


SUMO/sentrin specific peptidase 8


chr13_-_111490028 0.268 ENSMUST00000091236.4
Gpbp1
GC-rich promoter binding protein 1
chr13_-_111490111 0.249 ENSMUST00000047627.7
Gpbp1
GC-rich promoter binding protein 1
chr9_+_48985358 0.246 ENSMUST00000047349.6
Usp28
ubiquitin specific peptidase 28
chrX_+_36195950 0.245 ENSMUST00000115257.1
Zcchc12
zinc finger, CCHC domain containing 12
chrX_+_7842056 0.241 ENSMUST00000115667.3
ENSMUST00000115668.3
ENSMUST00000115665.1
Otud5


OTU domain containing 5


chr1_+_135132693 0.208 ENSMUST00000049449.4
Ptpn7
protein tyrosine phosphatase, non-receptor type 7
chr7_+_126759601 0.192 ENSMUST00000050201.4
ENSMUST00000057669.9
Mapk3

mitogen-activated protein kinase 3

chrX_+_36195904 0.184 ENSMUST00000115258.2
Zcchc12
zinc finger, CCHC domain containing 12
chr15_-_38078842 0.177 ENSMUST00000110336.2
Ubr5
ubiquitin protein ligase E3 component n-recognin 5
chr13_+_55445301 0.173 ENSMUST00000001115.8
ENSMUST00000099482.3
Grk6

G protein-coupled receptor kinase 6

chrX_+_36195938 0.151 ENSMUST00000048067.3
Zcchc12
zinc finger, CCHC domain containing 12
chr2_+_91922178 0.097 ENSMUST00000170432.1
Chrm4
cholinergic receptor, muscarinic 4
chr9_+_114688782 0.081 ENSMUST00000047404.6
Dync1li1
dynein cytoplasmic 1 light intermediate chain 1
chr2_+_180589245 0.060 ENSMUST00000029087.3
Ogfr
opioid growth factor receptor
chr6_+_127149389 0.050 ENSMUST00000180811.1
9330179D12Rik
RIKEN cDNA 9330179D12 gene
chr4_-_99120898 0.009 ENSMUST00000075836.5
Dock7
dedicator of cytokinesis 7
chr2_-_66634952 0.003 ENSMUST00000100064.2
ENSMUST00000100063.2
Scn9a

sodium channel, voltage-gated, type IX, alpha


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.2 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
0.8 2.4 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.7 2.0 GO:0045819 plasmacytoid dendritic cell activation(GO:0002270) positive regulation of glycogen catabolic process(GO:0045819)
0.7 2.0 GO:1904975 response to bleomycin(GO:1904975) cellular response to bleomycin(GO:1904976)
0.6 1.8 GO:0003100 angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001998) regulation of blood vessel size by renin-angiotensin(GO:0002034) renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure(GO:0003072) regulation of systemic arterial blood pressure by endothelin(GO:0003100) beta selection(GO:0043366) response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869)
0.5 11.4 GO:0038092 nodal signaling pathway(GO:0038092)
0.5 2.1 GO:0002572 pro-T cell differentiation(GO:0002572)
0.5 1.9 GO:0044340 canonical Wnt signaling pathway involved in regulation of cell proliferation(GO:0044340)
0.4 7.4 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.4 8.4 GO:0060044 negative regulation of cardiac muscle cell proliferation(GO:0060044)
0.4 1.1 GO:0010752 negative regulation of antigen processing and presentation(GO:0002578) negative regulation of nitric oxide mediated signal transduction(GO:0010751) regulation of cGMP-mediated signaling(GO:0010752)
0.3 1.4 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.3 1.2 GO:2000383 regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384)
0.3 1.1 GO:0048319 axial mesoderm morphogenesis(GO:0048319)
0.2 1.2 GO:2000325 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.2 1.1 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.2 1.7 GO:0000050 urea cycle(GO:0000050) urea metabolic process(GO:0019627)
0.2 1.8 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.2 1.5 GO:1902510 regulation of apoptotic DNA fragmentation(GO:1902510)
0.2 0.5 GO:0045014 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) detection of glucose(GO:0051594)
0.2 1.3 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.1 0.5 GO:0045358 negative regulation of interferon-beta biosynthetic process(GO:0045358)
0.1 2.0 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.1 2.6 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.1 3.8 GO:0006783 heme biosynthetic process(GO:0006783)
0.1 1.1 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.1 0.4 GO:1905077 negative regulation of interleukin-17 secretion(GO:1905077)
0.1 1.3 GO:0030238 male sex determination(GO:0030238)
0.1 1.1 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.1 1.3 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.1 1.7 GO:0001967 suckling behavior(GO:0001967)
0.1 2.1 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.1 0.2 GO:0010360 negative regulation of anion channel activity(GO:0010360)
0.1 4.0 GO:0070613 regulation of protein processing(GO:0070613)
0.0 1.1 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894)
0.0 0.6 GO:2000807 regulation of synaptic vesicle clustering(GO:2000807)
0.0 1.6 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 1.3 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 1.2 GO:0044030 regulation of DNA methylation(GO:0044030)
0.0 1.5 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 2.4 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.0 1.9 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.0 0.2 GO:0000189 MAPK import into nucleus(GO:0000189) outer ear morphogenesis(GO:0042473)
0.0 0.3 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.0 1.6 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.0 0.9 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.0 4.0 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.0 1.7 GO:0043966 histone H3 acetylation(GO:0043966)
0.0 0.9 GO:0006270 DNA replication initiation(GO:0006270)
0.0 1.2 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.0 0.3 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.1 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.0 2.5 GO:0051607 defense response to virus(GO:0051607)
0.0 0.5 GO:0003170 heart valve development(GO:0003170)
0.0 1.5 GO:0007601 visual perception(GO:0007601)
0.0 0.6 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.0 0.1 GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 7.4 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
0.6 1.7 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.4 1.3 GO:0033186 CAF-1 complex(GO:0033186)
0.4 1.1 GO:0005577 fibrinogen complex(GO:0005577)
0.2 1.5 GO:0089701 U2AF(GO:0089701)
0.1 2.3 GO:0032593 insulin-responsive compartment(GO:0032593)
0.1 1.1 GO:0016461 unconventional myosin complex(GO:0016461)
0.1 1.2 GO:0045298 tubulin complex(GO:0045298)
0.1 0.9 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1 1.1 GO:1990909 Wnt signalosome(GO:1990909)
0.1 1.7 GO:0030914 STAGA complex(GO:0030914)
0.1 1.1 GO:0031011 Ino80 complex(GO:0031011)
0.1 1.1 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 1.3 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 2.4 GO:0016235 aggresome(GO:0016235)
0.0 0.5 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 1.2 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 1.7 GO:1990391 DNA repair complex(GO:1990391)
0.0 7.2 GO:0001726 ruffle(GO:0001726)
0.0 0.5 GO:0035253 ciliary rootlet(GO:0035253)
0.0 1.5 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 7.7 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.2 GO:0031143 pseudopodium(GO:0031143)
0.0 2.6 GO:0005681 spliceosomal complex(GO:0005681)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0000402 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)
0.5 1.5 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.5 1.5 GO:0005118 sevenless binding(GO:0005118)
0.4 8.2 GO:0070410 co-SMAD binding(GO:0070410)
0.4 7.4 GO:0000400 four-way junction DNA binding(GO:0000400)
0.4 1.1 GO:0070052 collagen V binding(GO:0070052)
0.3 1.3 GO:0045131 pre-mRNA branch point binding(GO:0045131)
0.3 1.4 GO:0043532 angiostatin binding(GO:0043532)
0.2 1.8 GO:0051022 Rho GDP-dissociation inhibitor binding(GO:0051022)
0.1 1.5 GO:0050733 RS domain binding(GO:0050733)
0.1 1.7 GO:0001013 RNA polymerase I regulatory region DNA binding(GO:0001013)
0.1 2.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 0.5 GO:0043426 MRF binding(GO:0043426)
0.1 2.1 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.1 1.1 GO:0070411 I-SMAD binding(GO:0070411)
0.1 1.3 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 8.9 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 0.9 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 2.3 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 1.1 GO:0008143 poly(A) binding(GO:0008143)
0.0 0.2 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 1.3 GO:0070064 proline-rich region binding(GO:0070064)
0.0 2.5 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 2.9 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 1.9 GO:0005109 frizzled binding(GO:0005109)
0.0 1.1 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 0.3 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.2 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.0 1.2 GO:0032183 SUMO binding(GO:0032183)
0.0 1.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 1.1 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 1.7 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 4.2 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 4.2 GO:0042393 histone binding(GO:0042393)
0.0 7.2 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.1 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 1.2 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0 6.6 GO:0008134 transcription factor binding(GO:0008134)
0.0 0.2 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.2 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 2.1 GO:0017124 SH3 domain binding(GO:0017124)
0.0 1.8 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.5 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.1 1.8 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.1 1.9 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 3.0 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.1 2.0 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.1 8.2 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 2.0 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 1.4 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 1.6 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.1 1.5 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.1 4.3 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.0 1.1 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 2.4 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.0 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 1.6 PID_E2F_PATHWAY E2F transcription factor network
0.0 1.2 PID_PLK1_PATHWAY PLK1 signaling events
0.0 0.2 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 2.1 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.2 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.6 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.5 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 9.8 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2 2.5 REACTOME_REGULATION_OF_IFNG_SIGNALING Genes involved in Regulation of IFNG signaling
0.1 2.2 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.1 3.2 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.1 0.9 REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.1 1.8 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 2.1 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.1 8.3 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 1.1 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.5 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 1.1 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 1.5 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.0 1.1 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.6 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 1.1 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+