Motif ID: Elf1_Elf2_Etv2_Elf4

Z-value: 2.516

Transcription factors associated with Elf1_Elf2_Etv2_Elf4:

Gene SymbolEntrez IDGene Name
Elf1 ENSMUSG00000036461.9 Elf1
Elf2 ENSMUSG00000037174.12 Elf2
Elf4 ENSMUSG00000031103.6 Elf4
Etv2 ENSMUSG00000006311.8 Etv2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Elf1mm10_v2_chr14_+_79515618_795156940.375.7e-03Click!
Elf2mm10_v2_chr3_-_51340628_51340681-0.211.3e-01Click!
Elf4mm10_v2_chrX_-_48454152_48454193-0.047.5e-01Click!


Activity profile for motif Elf1_Elf2_Etv2_Elf4.

activity profile for motif Elf1_Elf2_Etv2_Elf4


Sorted Z-values histogram for motif Elf1_Elf2_Etv2_Elf4

Sorted Z-values for motif Elf1_Elf2_Etv2_Elf4



Network of associatons between targets according to the STRING database.



First level regulatory network of Elf1_Elf2_Etv2_Elf4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_127042420 23.137 ENSMUST00000032915.6
 Kif22
kinesin family member 22
chr19_+_6084983 21.300 ENSMUST00000025704.2
 Cdca5
cell division cycle associated 5
chr4_-_63403330 20.102 ENSMUST00000035724.4
 Akna
AT-hook transcription factor
chr16_+_48994185 19.638 ENSMUST00000117994.1
ENSMUST00000048374.5
 C330027C09Rik

RIKEN cDNA C330027C09 gene

chrX_+_100625737 18.369 ENSMUST00000048962.3
 Kif4
kinesin family member 4
chr16_-_18811972 18.000 ENSMUST00000000028.7
ENSMUST00000115585.1
 Cdc45

cell division cycle 45

chr2_+_5845243 17.905 ENSMUST00000127116.1
 Nudt5
nudix (nucleoside diphosphate linked moiety X)-type motif 5
chr11_-_94653964 17.029 ENSMUST00000039949.4
 Eme1
essential meiotic endonuclease 1 homolog 1 (S. pombe)
chr2_+_105682463 16.994 ENSMUST00000140173.1
ENSMUST00000135412.1
ENSMUST00000138365.1
ENSMUST00000145744.1
 Pax6



paired box gene 6



chr2_+_156840077 16.593 ENSMUST00000081335.6
ENSMUST00000073352.3
 Tgif2

TGFB-induced factor homeobox 2

chr11_-_12037391 15.966 ENSMUST00000093321.5
 Grb10
growth factor receptor bound protein 10
chr6_-_23248264 15.668 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr4_-_118437331 15.507 ENSMUST00000006565.6
 Cdc20
cell division cycle 20
chr2_-_5012716 15.223 ENSMUST00000027980.7
 Mcm10
minichromosome maintenance deficient 10 (S. cerevisiae)
chr1_+_84839833 15.122 ENSMUST00000097672.3
 Fbxo36
F-box protein 36
chr19_-_9899450 14.667 ENSMUST00000025562.7
 Incenp
inner centromere protein
chr2_+_118814237 13.970 ENSMUST00000028803.7
ENSMUST00000126045.1
 Knstrn

kinetochore-localized astrin/SPAG5 binding

chr11_+_61485431 13.538 ENSMUST00000064783.3
ENSMUST00000040522.6
 Mfap4

microfibrillar-associated protein 4

chr5_+_33658567 13.360 ENSMUST00000114426.3
 Tacc3
transforming, acidic coiled-coil containing protein 3
chr9_-_70421533 13.274 ENSMUST00000034742.6
 Ccnb2
cyclin B2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,039 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 141.3 GO:0008380 RNA splicing(GO:0008380)
2.0 66.4 GO:0007080 mitotic metaphase plate congression(GO:0007080)
1.6 44.7 GO:0006270 DNA replication initiation(GO:0006270)
2.6 43.4 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
10.1 40.2 GO:0019323 pentose catabolic process(GO:0019323)
4.0 39.6 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
1.0 37.4 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.8 36.9 GO:0002181 cytoplasmic translation(GO:0002181)
1.3 35.2 GO:0034724 DNA replication-independent nucleosome organization(GO:0034724)
1.5 34.9 GO:0000028 ribosomal small subunit assembly(GO:0000028)
2.4 33.3 GO:0022027 interkinetic nuclear migration(GO:0022027)
1.5 33.2 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
1.2 31.6 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
7.3 29.0 GO:0007056 spindle assembly involved in female meiosis(GO:0007056)
0.8 28.8 GO:0006284 base-excision repair(GO:0006284)
9.2 27.6 GO:0071163 DNA replication preinitiation complex assembly(GO:0071163)
3.8 26.8 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
1.1 26.7 GO:0034508 centromere complex assembly(GO:0034508)
0.2 26.4 GO:0008360 regulation of cell shape(GO:0008360)
4.3 25.9 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 379 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 288.9 GO:0005634 nucleus(GO:0005634)
1.5 84.1 GO:0005871 kinesin complex(GO:0005871)
0.2 84.1 GO:0005730 nucleolus(GO:0005730)
1.1 81.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.3 80.6 GO:0016607 nuclear speck(GO:0016607)
0.7 71.7 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
1.3 68.5 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 61.4 GO:0000785 chromatin(GO:0000785)
0.5 46.3 GO:0005681 spliceosomal complex(GO:0005681)
0.6 41.0 GO:0072686 mitotic spindle(GO:0072686)
0.7 40.5 GO:0015934 large ribosomal subunit(GO:0015934)
2.2 37.4 GO:0031616 spindle pole centrosome(GO:0031616)
1.5 36.1 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
2.7 32.0 GO:0005687 U4 snRNP(GO:0005687)
1.2 31.2 GO:0005680 anaphase-promoting complex(GO:0005680)
3.6 28.8 GO:0005818 aster(GO:0005818)
0.4 28.4 GO:0005814 centriole(GO:0005814)
0.2 28.2 GO:0005667 transcription factor complex(GO:0005667)
0.2 26.7 GO:0001650 fibrillar center(GO:0001650)
8.3 24.9 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 592 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 154.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.4 107.7 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
1.2 79.7 GO:0003777 microtubule motor activity(GO:0003777)
0.4 53.9 GO:0042393 histone binding(GO:0042393)
3.5 48.8 GO:0003688 DNA replication origin binding(GO:0003688)
0.4 48.5 GO:0004386 helicase activity(GO:0004386)
0.5 48.1 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
1.4 41.9 GO:0017025 TBP-class protein binding(GO:0017025)
0.6 37.3 GO:0003743 translation initiation factor activity(GO:0003743)
0.7 32.0 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
5.0 30.3 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.7 29.3 GO:0031492 nucleosomal DNA binding(GO:0031492)
3.2 28.7 GO:1990446 U1 snRNP binding(GO:1990446)
0.7 28.4 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
9.3 27.9 GO:0044715 8-oxo-dGDP phosphatase activity(GO:0044715)
2.8 27.9 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
1.9 23.4 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)
2.9 22.9 GO:0061676 importin-alpha family protein binding(GO:0061676)
2.7 21.4 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
1.9 21.1 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 101 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 101.7 PID_AURORA_B_PATHWAY Aurora B signaling
1.4 64.9 PID_ATR_PATHWAY ATR signaling pathway
1.8 64.7 PID_AURORA_A_PATHWAY Aurora A signaling
1.3 55.8 PID_PLK1_PATHWAY PLK1 signaling events
0.6 39.0 PID_E2F_PATHWAY E2F transcription factor network
0.7 38.4 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
1.0 37.2 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.4 36.6 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.6 33.2 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
1.0 26.0 PID_MYC_PATHWAY C-MYC pathway
0.3 21.9 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
1.0 20.0 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway
0.3 20.0 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.7 19.6 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.6 18.0 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.7 13.8 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.1 12.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.4 12.6 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.3 12.4 PID_RHOA_PATHWAY RhoA signaling pathway
0.7 11.8 PID_IL23_PATHWAY IL23-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 159 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 83.5 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
3.0 81.0 REACTOME_KINESINS Genes involved in Kinesins
1.2 77.3 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
1.3 71.9 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.6 68.7 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
1.2 66.3 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
2.5 57.4 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex
0.6 51.3 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
3.0 47.8 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.6 42.2 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.2 36.4 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
1.7 36.3 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
1.7 31.7 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
1.0 30.8 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
2.5 30.5 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
1.2 27.2 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.8 25.9 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
1.6 22.3 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
1.1 21.2 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.2 19.8 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives