Motif ID: Elf3

Z-value: 1.072


Transcription factors associated with Elf3:

Gene SymbolEntrez IDGene Name
Elf3 ENSMUSG00000003051.7 Elf3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Elf3mm10_v2_chr1_-_135258449_1352584720.481.8e-04Click!


Activity profile for motif Elf3.

activity profile for motif Elf3


Sorted Z-values histogram for motif Elf3

Sorted Z-values for motif Elf3



Network of associatons between targets according to the STRING database.



First level regulatory network of Elf3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_35049966 10.709 ENSMUST00000007257.9
 Clic1
chloride intracellular channel 1
chr14_-_70207637 7.572 ENSMUST00000022682.5
 Sorbs3
sorbin and SH3 domain containing 3
chr12_-_65172560 6.888 ENSMUST00000052201.8
 Mis18bp1
MIS18 binding protein 1
chr11_+_78324200 6.598 ENSMUST00000102478.3
 Aldoc
aldolase C, fructose-bisphosphate
chr2_+_164562579 6.474 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
 Wfdc2


WAP four-disulfide core domain 2


chr11_+_115163333 5.862 ENSMUST00000021077.3
 Slc9a3r1
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1
chr10_-_83648713 5.817 ENSMUST00000020500.7
 Appl2
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
chr11_-_55419898 5.505 ENSMUST00000108858.1
ENSMUST00000141530.1
 Sparc

secreted acidic cysteine rich glycoprotein

chr15_+_79516396 5.359 ENSMUST00000010974.7
 Kdelr3
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
chr7_-_102250086 5.316 ENSMUST00000106923.1
ENSMUST00000098230.4
 Rhog

ras homolog gene family, member G

chr14_-_54577578 5.272 ENSMUST00000054487.8
 Ajuba
ajuba LIM protein
chr19_+_5740885 5.229 ENSMUST00000081496.5
 Ltbp3
latent transforming growth factor beta binding protein 3
chr6_+_15720654 4.373 ENSMUST00000101663.3
 Mdfic
MyoD family inhibitor domain containing
chrX_+_169685191 4.247 ENSMUST00000112104.1
ENSMUST00000112107.1
 Mid1

midline 1

chr13_-_103920508 4.247 ENSMUST00000053927.5
ENSMUST00000091269.4
ENSMUST00000022222.5
 Erbb2ip


Erbb2 interacting protein


chr19_-_50678642 4.169 ENSMUST00000072685.6
ENSMUST00000164039.2
 Sorcs1

VPS10 domain receptor protein SORCS 1

chr4_-_53159885 4.119 ENSMUST00000030010.3
 Abca1
ATP-binding cassette, sub-family A (ABC1), member 1
chr1_+_138963709 4.062 ENSMUST00000168527.1
 Dennd1b
DENN/MADD domain containing 1B
chr1_+_136467958 3.914 ENSMUST00000047817.6
 Kif14
kinesin family member 14
chr13_-_103920295 3.759 ENSMUST00000169083.1
 Erbb2ip
Erbb2 interacting protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 120 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 11.4 GO:1902476 chloride transmembrane transport(GO:1902476)
0.3 7.5 GO:0050434 positive regulation of viral transcription(GO:0050434)
0.1 6.9 GO:0051496 positive regulation of stress fiber assembly(GO:0051496)
0.7 6.6 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
1.2 6.0 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
2.0 5.9 GO:0042939 glutathione transport(GO:0034635) tripeptide transport(GO:0042939)
1.0 5.7 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
1.4 5.6 GO:0097211 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.2 5.5 GO:0001937 negative regulation of endothelial cell proliferation(GO:0001937)
0.8 5.4 GO:0006621 protein retention in ER lumen(GO:0006621)
0.8 5.3 GO:0035331 negative regulation of hippo signaling(GO:0035331)
1.7 5.2 GO:1902460 transforming growth factor beta activation(GO:0036363) regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
1.3 5.0 GO:0055099 response to high density lipoprotein particle(GO:0055099)
0.6 5.0 GO:0035743 CD4-positive, alpha-beta T cell cytokine production(GO:0035743)
1.5 4.5 GO:2000564 CD8-positive, alpha-beta T cell proliferation(GO:0035740) negative regulation of regulatory T cell differentiation(GO:0045590) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564)
0.0 4.5 GO:0051604 protein maturation(GO:0051604)
0.2 4.4 GO:1900027 regulation of ruffle assembly(GO:1900027)
0.4 4.3 GO:0036462 TRAIL-activated apoptotic signaling pathway(GO:0036462)
0.5 4.2 GO:0035372 protein localization to microtubule(GO:0035372)
1.0 3.9 GO:0021698 cerebellar cortex structural organization(GO:0021698)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 74 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 13.2 GO:0016607 nuclear speck(GO:0016607)
0.3 11.4 GO:0034707 chloride channel complex(GO:0034707)
0.0 10.6 GO:0005925 focal adhesion(GO:0005925)
0.3 8.1 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 7.4 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.5 6.9 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
0.1 6.5 GO:0072562 blood microparticle(GO:0072562)
0.5 5.9 GO:0032426 stereocilium tip(GO:0032426)
1.9 5.7 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.2 5.6 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
1.4 5.5 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 5.3 GO:0000776 kinetochore(GO:0000776)
0.6 5.0 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 5.0 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
1.4 4.3 GO:0030690 Noc1p-Noc2p complex(GO:0030690)
0.2 4.1 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.1 3.9 GO:0051233 spindle midzone(GO:0051233)
0.8 3.8 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.1 3.4 GO:0005682 U5 snRNP(GO:0005682)
0.1 3.3 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 97 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 18.9 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987)
0.1 9.1 GO:0030165 PDZ domain binding(GO:0030165)
0.5 7.9 GO:0017166 vinculin binding(GO:0017166)
0.1 7.5 GO:0005254 chloride channel activity(GO:0005254)
0.4 6.7 GO:0030957 Tat protein binding(GO:0030957)
1.1 6.6 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
1.3 6.5 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.5 5.9 GO:0017081 chloride channel regulator activity(GO:0017081)
1.3 5.4 GO:0046923 ER retention sequence binding(GO:0046923)
0.4 5.3 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 5.3 GO:0005525 GTP binding(GO:0005525)
0.1 5.1 GO:0050840 extracellular matrix binding(GO:0050840)
0.2 4.9 GO:0050431 transforming growth factor beta binding(GO:0050431)
1.1 4.3 GO:0035877 death effector domain binding(GO:0035877)
0.0 4.2 GO:0051219 phosphoprotein binding(GO:0051219)
0.0 4.2 GO:0003735 structural constituent of ribosome(GO:0003735)
1.4 4.1 GO:0030226 apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.1 3.9 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
1.3 3.8 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.4 3.7 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 7.9 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.2 7.5 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 5.9 PID_TXA2PATHWAY Thromboxane A2 receptor signaling
0.1 4.8 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 4.4 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.5 4.3 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1 3.4 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.2 3.0 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.1 2.9 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.1 2.8 PID_IL5_PATHWAY IL5-mediated signaling events
0.1 2.7 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.1 2.5 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 2.4 PID_RHOA_PATHWAY RhoA signaling pathway
0.1 2.2 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 2.0 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 1.8 PID_S1P_S1P3_PATHWAY S1P3 pathway
0.1 1.5 ST_B_CELL_ANTIGEN_RECEPTOR B Cell Antigen Receptor
0.0 1.3 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 1.1 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.4 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.2 7.6 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.2 7.2 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 6.9 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 6.5 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.2 5.7 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.1 5.2 REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.4 5.0 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.3 4.8 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.2 4.5 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.3 4.3 REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.1 3.9 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.2 3.5 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.6 3.0 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.4 3.0 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.3 3.0 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.0 2.7 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.1 2.5 REACTOME_G1_PHASE Genes involved in G1 Phase
0.4 2.4 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 2.2 REACTOME_SIGNALING_BY_SCF_KIT Genes involved in Signaling by SCF-KIT