Motif ID: En1

Z-value: 0.591


Transcription factors associated with En1:

Gene SymbolEntrez IDGene Name
En1 ENSMUSG00000058665.7 En1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
En1mm10_v2_chr1_+_120602405_120602418-0.221.0e-01Click!


Activity profile for motif En1.

activity profile for motif En1


Sorted Z-values histogram for motif En1

Sorted Z-values for motif En1



Network of associatons between targets according to the STRING database.



First level regulatory network of En1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_+_67234620 3.719 ENSMUST00000176029.1
 Ebf2
early B cell factor 2
chr6_-_23248264 3.488 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr16_-_26989974 2.506 ENSMUST00000089832.4
 Gmnc
geminin coiled-coil domain containing
chr19_+_60144682 2.240 ENSMUST00000065383.4
 E330013P04Rik
RIKEN cDNA E330013P04 gene
chr1_+_6487231 2.114 ENSMUST00000140079.1
ENSMUST00000131494.1
 St18

suppression of tumorigenicity 18

chr12_+_109453455 1.686 ENSMUST00000109844.4
ENSMUST00000109842.2
ENSMUST00000109843.1
ENSMUST00000109846.4
ENSMUST00000173539.1
ENSMUST00000109841.2
 Dlk1





delta-like 1 homolog (Drosophila)





chr15_-_56694525 1.602 ENSMUST00000050544.7
 Has2
hyaluronan synthase 2
chr1_-_158814469 1.580 ENSMUST00000161589.2
 Pappa2
pappalysin 2
chr19_+_47014672 1.561 ENSMUST00000037636.3
 Ina
internexin neuronal intermediate filament protein, alpha
chr16_-_59555752 1.430 ENSMUST00000179383.1
ENSMUST00000044604.8
 Crybg3

beta-gamma crystallin domain containing 3

chr17_+_35841668 1.308 ENSMUST00000174124.1
 Mdc1
mediator of DNA damage checkpoint 1
chr1_+_72824482 1.299 ENSMUST00000047328.4
 Igfbp2
insulin-like growth factor binding protein 2
chr1_-_87156127 1.291 ENSMUST00000160810.1
 Ecel1
endothelin converting enzyme-like 1
chr6_+_4755327 1.209 ENSMUST00000176551.1
 Peg10
paternally expressed 10
chr12_+_109452833 1.197 ENSMUST00000056110.8
 Dlk1
delta-like 1 homolog (Drosophila)
chr16_-_45953565 1.185 ENSMUST00000134802.1
 Phldb2
pleckstrin homology-like domain, family B, member 2
chr5_+_92925400 1.085 ENSMUST00000172706.1
 Shroom3
shroom family member 3
chr4_-_129227883 1.075 ENSMUST00000106051.1
 C77080
expressed sequence C77080
chr3_+_141465564 1.036 ENSMUST00000106236.2
ENSMUST00000075282.3
 Unc5c

unc-5 homolog C (C. elegans)

chr11_-_77725281 0.976 ENSMUST00000078623.4
 Cryba1
crystallin, beta A1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 150 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.7 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.6 3.5 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.4 2.7 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.1 2.5 GO:0045780 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.1 2.5 GO:0006270 DNA replication initiation(GO:0006270)
0.2 2.1 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.2 1.9 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.2 1.9 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.4 1.6 GO:1900623 positive regulation of keratinocyte proliferation(GO:0010838) regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.0 1.6 GO:0045773 positive regulation of axon extension(GO:0045773)
0.0 1.5 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.0 1.4 GO:0003016 respiratory system process(GO:0003016)
0.0 1.4 GO:0060349 bone morphogenesis(GO:0060349)
0.1 1.3 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.1 1.3 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0 1.2 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 1.1 GO:0030071 regulation of mitotic metaphase/anaphase transition(GO:0030071) regulation of metaphase/anaphase transition of cell cycle(GO:1902099)
0.0 1.1 GO:0001843 neural tube closure(GO:0001843) tube closure(GO:0060606)
0.2 1.0 GO:2000210 positive regulation of anoikis(GO:2000210)
0.0 1.0 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.7 GO:0045180 basal cortex(GO:0045180)
0.0 1.9 GO:0032993 protein-DNA complex(GO:0032993)
0.2 1.6 GO:0005883 neurofilament(GO:0005883)
0.1 1.0 GO:0045277 respiratory chain complex IV(GO:0045277)
0.2 0.9 GO:0061689 tricellular tight junction(GO:0061689)
0.0 0.8 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.8 GO:0005811 lipid particle(GO:0005811)
0.1 0.7 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 0.7 GO:0000242 pericentriolar material(GO:0000242)
0.0 0.7 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 0.7 GO:0005657 replication fork(GO:0005657)
0.2 0.6 GO:1990047 spindle matrix(GO:1990047)
0.1 0.6 GO:0044611 nuclear pore inner ring(GO:0044611)
0.1 0.6 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 0.6 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.6 GO:0016235 aggresome(GO:0016235)
0.1 0.5 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 0.5 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.5 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.5 GO:0035102 PRC1 complex(GO:0035102)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 106 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.5 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 3.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 2.2 GO:0001047 core promoter binding(GO:0001047)
0.3 1.9 GO:0005042 netrin receptor activity(GO:0005042)
0.3 1.9 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.5 1.6 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.2 1.3 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 1.1 GO:0008308 voltage-gated anion channel activity(GO:0008308)
0.0 1.1 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 1.1 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 1.1 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.1 1.0 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 1.0 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.9 GO:0008301 DNA binding, bending(GO:0008301)
0.1 0.9 GO:0030228 lipoprotein particle receptor activity(GO:0030228)
0.0 0.9 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.9 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.3 0.8 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.2 0.8 GO:1902379 chemoattractant activity involved in axon guidance(GO:1902379)
0.0 0.8 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)

Gene overrepresentation in C2:CP category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.8 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.9 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 1.4 PID_ATM_PATHWAY ATM pathway
0.0 1.1 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 0.8 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.8 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.8 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.1 0.7 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway
0.0 0.4 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 0.4 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.4 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.3 PID_AR_NONGENOMIC_PATHWAY Nongenotropic Androgen signaling
0.0 0.3 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.3 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 0.2 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.2 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.3 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.2 2.9 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 1.9 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 1.6 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.1 1.4 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 1.2 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.1 1.0 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 0.8 REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.8 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 0.7 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.7 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 0.7 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.7 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.1 0.6 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.6 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.6 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.6 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.6 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1 0.5 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.1 0.5 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels