Motif ID: En2

Z-value: 0.556


Transcription factors associated with En2:

Gene SymbolEntrez IDGene Name
En2 ENSMUSG00000039095.7 En2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
En2mm10_v2_chr5_+_28165690_28165717-0.239.0e-02Click!


Activity profile for motif En2.

activity profile for motif En2


Sorted Z-values histogram for motif En2

Sorted Z-values for motif En2



Network of associatons between targets according to the STRING database.



First level regulatory network of En2

PNG image of the network

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Top targets:


Showing 1 to 20 of 165 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_139543889 5.028 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chrX_-_60893430 4.976 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr14_-_67715585 4.873 ENSMUST00000163100.1
ENSMUST00000132705.1
ENSMUST00000124045.1
 Cdca2


cell division cycle associated 2


chr5_-_53707532 4.677 ENSMUST00000031093.3
 Cckar
cholecystokinin A receptor
chr2_+_25372315 4.016 ENSMUST00000028329.6
ENSMUST00000114293.2
ENSMUST00000100323.2
 Sapcd2


suppressor APC domain containing 2


chr5_+_33658123 3.727 ENSMUST00000074849.6
ENSMUST00000079534.4
 Tacc3

transforming, acidic coiled-coil containing protein 3

chr9_+_65890237 3.468 ENSMUST00000045802.6
 2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr4_+_109978004 3.393 ENSMUST00000061187.3
 Dmrta2
doublesex and mab-3 related transcription factor like family A2
chr6_+_8948608 3.370 ENSMUST00000160300.1
 Nxph1
neurexophilin 1
chr3_-_27153861 3.237 ENSMUST00000108300.1
ENSMUST00000108298.2
 Ect2

ect2 oncogene

chr8_+_83955507 3.107 ENSMUST00000005607.8
 Asf1b
ASF1 anti-silencing function 1 homolog B (S. cerevisiae)
chr3_-_27153844 3.099 ENSMUST00000176242.2
ENSMUST00000176780.1
 Ect2

ect2 oncogene

chr2_+_20737306 3.021 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4

chr5_+_33658567 2.992 ENSMUST00000114426.3
 Tacc3
transforming, acidic coiled-coil containing protein 3
chr6_+_4755327 2.841 ENSMUST00000176551.1
 Peg10
paternally expressed 10
chr4_+_62583568 2.619 ENSMUST00000098031.3
 Rgs3
regulator of G-protein signaling 3
chr5_+_33658550 2.375 ENSMUST00000152847.1
 Tacc3
transforming, acidic coiled-coil containing protein 3
chr18_-_80986578 2.351 ENSMUST00000057950.7
 Sall3
sal-like 3 (Drosophila)
chrX_+_134308084 2.328 ENSMUST00000081064.5
ENSMUST00000101251.1
ENSMUST00000129782.1
 Cenpi


centromere protein I


chr13_-_47106176 2.302 ENSMUST00000021807.6
ENSMUST00000135278.1
 Dek

DEK oncogene (DNA binding)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 9.1 GO:0030953 astral microtubule organization(GO:0030953)
0.2 6.5 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.4 6.3 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.6 5.0 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.2 4.9 GO:0007530 sex determination(GO:0007530)
0.1 4.9 GO:0035307 positive regulation of protein dephosphorylation(GO:0035307)
1.6 4.7 GO:0090274 positive regulation of somatostatin secretion(GO:0090274)
0.8 4.1 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.2 3.6 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.2 3.4 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.1 2.6 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.2 2.4 GO:0021891 olfactory bulb interneuron development(GO:0021891)
0.5 2.3 GO:2001032 regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.1 2.3 GO:0034508 centromere complex assembly(GO:0034508)
0.2 2.2 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 2.0 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.0 1.9 GO:0030833 regulation of actin filament polymerization(GO:0030833)
0.3 1.6 GO:0043415 positive regulation of skeletal muscle tissue regeneration(GO:0043415)
0.0 1.6 GO:0009409 response to cold(GO:0009409)
0.4 1.5 GO:0061743 motor learning(GO:0061743)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 6.3 GO:0097149 centralspindlin complex(GO:0097149)
0.1 3.6 GO:0005871 kinesin complex(GO:0005871)
0.0 3.6 GO:0043195 terminal bouton(GO:0043195)
0.0 3.2 GO:0043292 contractile fiber(GO:0043292)
0.0 2.3 GO:0070469 respiratory chain(GO:0070469)
0.1 2.2 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 2.0 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 1.9 GO:0000776 kinetochore(GO:0000776)
0.0 1.7 GO:0000786 nucleosome(GO:0000786)
0.0 1.5 GO:0001772 immunological synapse(GO:0001772)
0.0 1.4 GO:0032420 stereocilium(GO:0032420)
0.0 1.2 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.9 GO:0005581 collagen trimer(GO:0005581)
0.1 0.8 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.2 0.7 GO:0071438 invadopodium membrane(GO:0071438)
0.1 0.7 GO:0044301 climbing fiber(GO:0044301)
0.1 0.7 GO:0005915 zonula adherens(GO:0005915)
0.0 0.7 GO:0036038 MKS complex(GO:0036038)
0.0 0.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 0.6 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.9 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 4.3 GO:0017048 Rho GTPase binding(GO:0017048)
0.2 4.1 GO:0008483 transaminase activity(GO:0008483)
0.1 4.0 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 3.6 GO:0003777 microtubule motor activity(GO:0003777)
0.1 3.5 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.0 3.2 GO:0042393 histone binding(GO:0042393)
0.1 2.3 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 2.2 GO:0097602 cullin family protein binding(GO:0097602)
0.1 1.7 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 1.6 GO:0033613 activating transcription factor binding(GO:0033613)
0.1 1.4 GO:0048185 activin binding(GO:0048185)
0.1 1.2 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.1 1.2 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.0 1.1 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 1.0 GO:0050692 DBD domain binding(GO:0050692)
0.1 1.0 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 1.0 GO:0015144 carbohydrate transmembrane transporter activity(GO:0015144) carbohydrate transporter activity(GO:1901476)
0.0 0.9 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1 0.8 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)

Gene overrepresentation in C2:CP category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.0 PID_PLK1_PATHWAY PLK1 signaling events
0.2 6.0 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 3.4 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 3.2 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 2.2 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.4 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 1.0 PID_BMP_PATHWAY BMP receptor signaling
0.1 0.9 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.9 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.7 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 0.5 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.5 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.5 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 0.3 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.2 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.1 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 3.6 REACTOME_KINESINS Genes involved in Kinesins
0.0 3.5 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 3.5 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 3.1 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 2.3 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 0.9 REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.0 0.9 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.9 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.6 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 0.5 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 0.5 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.5 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.5 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.3 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.3 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.2 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.2 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation