Motif ID: Ep300

Z-value: 0.655


Transcription factors associated with Ep300:

Gene SymbolEntrez IDGene Name
Ep300 ENSMUSG00000055024.6 Ep300

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ep300mm10_v2_chr15_+_81586206_81586250-0.221.1e-01Click!


Activity profile for motif Ep300.

activity profile for motif Ep300


Sorted Z-values histogram for motif Ep300

Sorted Z-values for motif Ep300



Network of associatons between targets according to the STRING database.



First level regulatory network of Ep300

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_98348404 6.661 ENSMUST00000078694.6
 Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr9_-_29411736 5.318 ENSMUST00000115236.1
 Ntm
neurotrimin
chr1_-_21961581 4.157 ENSMUST00000029667.6
ENSMUST00000173058.1
ENSMUST00000173404.1
 Kcnq5


potassium voltage-gated channel, subfamily Q, member 5


chr19_+_23758819 3.872 ENSMUST00000025830.7
 Apba1
amyloid beta (A4) precursor protein binding, family A, member 1
chr6_+_65671590 3.709 ENSMUST00000054351.4
 Ndnf
neuron-derived neurotrophic factor
chr6_+_99692679 3.690 ENSMUST00000101122.1
 Gpr27
G protein-coupled receptor 27
chr1_-_21961942 3.531 ENSMUST00000115300.1
 Kcnq5
potassium voltage-gated channel, subfamily Q, member 5
chr18_+_51117754 3.531 ENSMUST00000116639.2
 Prr16
proline rich 16
chr11_+_97415527 3.529 ENSMUST00000121799.1
 Arhgap23
Rho GTPase activating protein 23
chr5_+_130448801 3.377 ENSMUST00000111288.2
 Caln1
calneuron 1
chr4_+_125490688 3.355 ENSMUST00000030676.7
 Grik3
glutamate receptor, ionotropic, kainate 3
chr6_-_136173492 3.308 ENSMUST00000111905.1
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr17_+_55445550 3.186 ENSMUST00000025000.3
 St6gal2
beta galactoside alpha 2,6 sialyltransferase 2
chr9_-_29412204 2.919 ENSMUST00000115237.1
 Ntm
neurotrimin
chr4_+_103313806 2.898 ENSMUST00000035780.3
 Oma1
OMA1 homolog, zinc metallopeptidase (S. cerevisiae)
chr1_-_87573825 2.863 ENSMUST00000068681.5
 Ngef
neuronal guanine nucleotide exchange factor
chr8_-_84800344 2.529 ENSMUST00000099070.3
 Nfix
nuclear factor I/X
chr1_-_83408190 2.386 ENSMUST00000160953.1
 Sphkap
SPHK1 interactor, AKAP domain containing
chr7_+_96522342 2.371 ENSMUST00000129737.1
 Tenm4
teneurin transmembrane protein 4
chr8_-_85840877 2.242 ENSMUST00000034140.7
 Itfg1
integrin alpha FG-GAP repeat containing 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 103 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.6 GO:0071805 potassium ion transmembrane transport(GO:0071805)
0.0 8.2 GO:0010977 negative regulation of neuron projection development(GO:0010977)
2.2 6.7 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.3 5.4 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
0.2 4.2 GO:0045793 positive regulation of cell size(GO:0045793)
0.5 3.8 GO:0005513 detection of calcium ion(GO:0005513)
1.2 3.7 GO:1900738 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
0.4 3.7 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) vascular wound healing(GO:0061042)
0.1 3.6 GO:0008045 motor neuron axon guidance(GO:0008045)
0.3 3.4 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.8 3.3 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.2 3.2 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.2 3.2 GO:0015693 magnesium ion transport(GO:0015693)
0.6 2.9 GO:0010637 diet induced thermogenesis(GO:0002024) negative regulation of mitochondrial fusion(GO:0010637)
0.3 2.9 GO:0061002 negative regulation of dendritic spine morphogenesis(GO:0061002)
0.5 2.6 GO:0098706 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.4 2.6 GO:1904217 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) regulation of serine C-palmitoyltransferase activity(GO:1904220) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.1 2.5 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.6 2.4 GO:0032289 central nervous system myelin formation(GO:0032289) cardiac cell fate specification(GO:0060912)
0.1 2.4 GO:0010738 regulation of protein kinase A signaling(GO:0010738)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.2 GO:0030118 clathrin coat(GO:0030118)
0.1 8.1 GO:0031225 anchored component of membrane(GO:0031225)
0.0 6.9 GO:0043025 neuronal cell body(GO:0043025)
0.1 6.0 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 4.1 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 3.9 GO:0000139 Golgi membrane(GO:0000139)
0.0 3.8 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.2 3.6 GO:0042101 T cell receptor complex(GO:0042101)
0.1 3.5 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 3.3 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.2 3.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 3.1 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 3.1 GO:0008021 synaptic vesicle(GO:0008021)
0.4 2.6 GO:0097443 sorting endosome(GO:0097443)
0.1 2.5 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 2.5 GO:0097440 apical dendrite(GO:0097440)
0.2 2.3 GO:0032584 growth cone membrane(GO:0032584)
0.0 2.2 GO:0030018 Z disc(GO:0030018)
0.2 2.1 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 2.0 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 82 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.0 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
2.2 6.7 GO:0031752 D3 dopamine receptor binding(GO:0031750) D5 dopamine receptor binding(GO:0031752)
0.3 4.7 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 4.4 GO:0017124 SH3 domain binding(GO:0017124)
0.2 3.8 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 3.7 GO:0008201 heparin binding(GO:0008201)
0.7 3.4 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.1 3.4 GO:0001540 beta-amyloid binding(GO:0001540)
0.4 3.3 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.6 3.2 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.2 3.2 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 3.0 GO:0008017 microtubule binding(GO:0008017)
0.0 3.0 GO:0005096 GTPase activator activity(GO:0005096)
0.1 2.9 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 2.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.2 2.6 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 2.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 2.4 GO:0051018 protein kinase A binding(GO:0051018)
0.1 2.3 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 2.3 GO:0008013 beta-catenin binding(GO:0008013)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.6 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 4.3 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 4.3 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.3 3.5 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 2.9 PID_CDC42_PATHWAY CDC42 signaling events
0.1 2.5 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.1 2.3 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 2.2 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 2.0 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.8 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.0 1.7 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 1.2 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.1 1.2 PID_ATM_PATHWAY ATM pathway
0.1 1.1 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 1.1 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 1.1 PID_VEGFR1_2_PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.1 1.0 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.7 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.0 0.7 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.0 0.7 PID_NCADHERIN_PATHWAY N-cadherin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.9 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.2 7.7 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 7.5 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 4.4 REACTOME_ASPARAGINE_N_LINKED_GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation
0.2 4.1 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.2 3.8 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.0 3.6 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.2 3.4 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 3.0 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 2.2 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.1 2.1 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.1 1.8 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.4 1.7 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.1 1.7 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.1 1.6 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 1.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 1.2 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 1.2 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 1.1 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.1 1.1 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK